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Gene: Insr (insulin receptor) Rattus norvegicus
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Symbol: Insr
Name: insulin receptor
Description: Exhibits several functions, including enzyme binding activity; insulin binding activity; and insulin receptor substrate binding activity. Involved in several processes, including animal organ development; neuron projection organization; and regulation of glucose metabolic process. Localizes to several cellular components, including dendrite membrane; neuronal cell body membrane; and yolk. Colocalizes with cell body and dendrite. Used to study chronic kidney disease; diabetic neuropathy; fatty liver disease (multiple); hepatocellular carcinoma; and type 2 diabetes mellitus. Biomarker of several diseases, including diabetes mellitus (multiple); fatty liver disease (multiple); hepatic encephalopathy; hepatocellular carcinoma; and short bowel syndrome. Human ortholog(s) of this gene implicated in Donohue syndrome; diabetes mellitus (multiple); familial hyperinsulinemic hypoglycemia 5; and reproductive organ cancer (multiple). Orthologous to human INSR (insulin receptor); PARTICIPATES IN altered leptin system pathway; insulin signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; INTERACTS WITH (+)-catechin; (3,4-dihydroxyphenyl)acetic acid; (S)-nicotine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: insulin receptor preproprotein; IR
Orthologs:
Homo sapiens (human) : INSR (insulin receptor)  HGNC  Alliance
Mus musculus (house mouse) : Insr (insulin receptor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Insr (insulin receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : INSR (insulin receptor)
Canis lupus familiaris (dog) : INSR (insulin receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Insr (insulin receptor)
Sus scrofa (pig) : INSR (insulin receptor)
Chlorocebus sabaeus (African green monkey) : INSR (insulin receptor)
Heterocephalus glaber (naked mole-rat) : Insr (insulin receptor)
more info ...
Is Marker For: Strains:   LEW-Tg(H1/tetO-RNAi:Insr)87Hrjb   LEW-Tg(H1/tetO-RNAi:Insr)4Hrjb  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0121,682,527 - 1,816,414 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl121,680,957 - 1,816,414 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0123,848,670 - 3,989,302 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4122,934,967 - 3,087,691 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1122,934,966 - 3,087,691 (+)NCBI
Celera123,053,590 - 3,185,991 (-)NCBICelera
Cytogenetic Map12p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Insr
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2917
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.