Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Insr (insulin receptor) Rattus norvegicus
Symbol: Insr
Name: insulin receptor
Description: Exhibits several functions, including enzyme binding activity; insulin binding activity; and insulin receptor substrate binding activity. Involved in several processes, including animal organ development; neuron projection organization; and regulation of glucose metabolic process. Localizes to several cellular components, including dendrite membrane; neuronal cell body membrane; and yolk. Colocalizes with cell body and dendrite. Used to study chronic kidney disease; diabetic neuropathy; fatty liver disease (multiple); hepatocellular carcinoma; and type 2 diabetes mellitus. Biomarker of several diseases, including diabetes mellitus (multiple); fatty liver disease (multiple); hepatic encephalopathy; hepatocellular carcinoma; and short bowel syndrome. Human ortholog(s) of this gene implicated in Donohue syndrome; diabetes mellitus (multiple); familial hyperinsulinemic hypoglycemia 5; and reproductive organ cancer (multiple). Orthologous to human INSR (insulin receptor); PARTICIPATES IN altered leptin system pathway; insulin signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; INTERACTS WITH (+)-catechin; (3,4-dihydroxyphenyl)acetic acid; (S)-nicotine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: insulin receptor preproprotein; IR
Homo sapiens (human) : INSR (insulin receptor)  HGNC  Alliance
Mus musculus (house mouse) : Insr (insulin receptor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Insr (insulin receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : INSR (insulin receptor)
Canis lupus familiaris (dog) : INSR (insulin receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Insr (insulin receptor)
Sus scrofa (pig) : INSR (insulin receptor)
Chlorocebus sabaeus (African green monkey) : INSR (insulin receptor)
Heterocephalus glaber (naked mole-rat) : Insr (insulin receptor)
more info ...
Is Marker For: Strains:   LEW-Tg(H1/tetO-RNAi:Insr)87Hrjb   LEW-Tg(H1/tetO-RNAi:Insr)4Hrjb  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0121,682,527 - 1,816,414 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl121,680,957 - 1,816,414 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0123,848,670 - 3,989,302 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4122,934,967 - 3,087,691 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1122,934,966 - 3,087,691 (+)NCBI
Celera123,053,590 - 3,185,991 (-)NCBICelera
Cytogenetic Map12p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Insr
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2917
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.