Dnm2 (dynamin 2) - Rat Genome Database

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Gene: Dnm2 (dynamin 2) Rattus norvegicus
Analyze
Symbol: Dnm2
Name: dynamin 2
RGD ID: 2513
Description: Enables several functions, including D2 dopamine receptor binding activity; enzyme binding activity; and protein domain specific binding activity. Involved in several processes, including positive regulation of transport; regulation of plasma membrane bounded cell projection assembly; and regulation of signal transduction. Located in several cellular components, including Golgi apparatus; cytoplasmic vesicle; and ruffle membrane. Part of protein-containing complex. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Colocalizes with growth cone. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate B; centronuclear myopathy 1; and lethal congenital contracture syndrome. Orthologous to human DNM2 (dynamin 2); PARTICIPATES IN platelet-derived growth factor signaling pathway; syndecan signaling pathway; vascular endothelial growth factor signaling pathway; INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DYIIAAB; dynamin-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2819,978,313 - 20,060,162 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,978,400 - 20,060,157 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx824,010,157 - 24,091,388 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0822,307,994 - 22,389,225 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0820,208,114 - 20,289,207 (+)NCBIRnor_WKY
Rnor_6.0822,458,869 - 22,540,649 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,458,899 - 22,540,524 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0822,512,875 - 22,594,760 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4820,527,130 - 20,610,749 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1820,527,130 - 20,610,749 (+)NCBI
Celera821,369,673 - 21,450,772 (+)NCBICelera
Cytogenetic Map8q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
butanal  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
CGP 52608  (ISO)
choline  (ISO)
chrysene  (ISO)
clofibrate  (ISO)
cocaine  (EXP)
Cuprizon  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (EXP,ISO)
folic acid  (ISO)
gentamycin  (EXP)
ivermectin  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
melatonin  (ISO)
N,N-diethyl-m-toluamide  (EXP)
nickel dichloride  (EXP)
nilotinib  (ISO)
NS-398  (ISO)
ozone  (ISO)
paraquat  (ISO)
PCB138  (EXP)
pentachlorophenol  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenol red  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
Pyridostigmine bromide  (EXP)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloroethene  (ISO)
titanium dioxide  (ISO)
Tributyltin oxide  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

References

References - curated
# Reference Title Reference Citation
1. Clathrin-dependent and independent endocytosis of glucose transporter 4 (GLUT4) in myoblasts: regulation by mitochondrial uncoupling. Antonescu CN, etal., Traffic. 2008 Jul;9(7):1173-90. doi: 10.1111/j.1600-0854.2008.00755.x. Epub 2008 Apr 24.
2. Dynamin 2 mediates fluid-phase micropinocytosis in epithelial cells. Cao H, etal., J Cell Sci. 2007 Dec 1;120(Pt 23):4167-77. Epub 2007 Nov 14.
3. Differential distribution of dynamin isoforms in mammalian cells. Cao H, etal., Mol Biol Cell. 1998 Sep;9(9):2595-609.
4. SRC-mediated phosphorylation of dynamin and cortactin regulates the "constitutive" endocytosis of transferrin. Cao H, etal., Mol Cell Biol. 2010 Feb;30(3):781-92. doi: 10.1128/MCB.00330-09. Epub 2009 Dec 7.
5. Actin and Arf1-dependent recruitment of a cortactin-dynamin complex to the Golgi regulates post-Golgi transport. Cao H, etal., Nat Cell Biol. 2005 May;7(5):483-92. Epub 2005 Apr 10.
6. The Abl/Arg substrate ArgBP2/nArgBP2 coordinates the function of multiple regulatory mechanisms converging on the actin cytoskeleton. Cestra G, etal., Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1731-6. Epub 2005 Jan 19.
7. Dynamin is a minibrain kinase/dual specificity Yak1-related kinase 1A substrate. Chen-Hwang MC, etal., J Biol Chem 2002 May 17;277(20):17597-604.
8. Identification of dynamin 2, an isoform ubiquitously expressed in rat tissues. Cook TA, etal., Proc Natl Acad Sci U S A 1994 Jan 18;91(2):644-8.
9. Dynamin regulates focal exocytosis in phagocytosing macrophages. Di A, etal., Mol Biol Cell. 2003 May;14(5):2016-28. Epub 2003 Feb 21.
10. Relevance of dopamine signals anchoring dynamin-2 to the plasma membrane during Na+,K+-ATPase endocytosis. Efendiev R, etal., J Biol Chem 2002 Nov 15;277(46):44108-14.
11. Plk2 attachment to NSF induces homeostatic removal of GluA2 during chronic overexcitation. Evers DM, etal., Nat Neurosci. 2010 Oct;13(10):1199-207. doi: 10.1038/nn.2624. Epub 2010 Aug 29.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. The F-BAR protein CIP4 promotes GLUT4 endocytosis through bidirectional interactions with N-WASp and Dynamin-2. Hartig SM, etal., J Cell Sci. 2009 Jul 1;122(Pt 13):2283-91. doi: 10.1242/jcs.041343. Epub 2009 Jun 9.
15. Nitric oxide and carbon monoxide antagonize TGF-beta through ligand-independent internalization of TbetaR1/ALK5. Hovater MB, etal., Am J Physiol Renal Physiol. 2014 Sep 15;307(6):F727-35. doi: 10.1152/ajprenal.00353.2014. Epub 2014 Aug 6.
16. Dynamin activates NO production in rat renal inner medullary collecting ducts via protein-protein interaction with NOS1. Hyndman KA, etal., Am J Physiol Renal Physiol. 2011 Apr 13.
17. Localization of dynamin 2 in rat seminiferous tubules during the spermatogenic cycle. Iguchi H, etal., Acta Med Okayama. 2002 Aug;56(4):205-9.
18. The XLID protein PQBP1 and the GTPase Dynamin 2 define a signaling link that orchestrates ciliary morphogenesis in postmitotic neurons. Ikeuchi Y, etal., Cell Rep. 2013 Sep 12;4(5):879-89. doi: 10.1016/j.celrep.2013.07.042. Epub 2013 Aug 29.
19. Dynamin-2 associates with the dopamine receptor signalplex and regulates internalization of activated D2 receptors. Kabbani N, etal., Cell Signal. 2004 Apr;16(4):497-503.
20. Myosin 1E interacts with synaptojanin-1 and dynamin and is involved in endocytosis. Krendel M, etal., FEBS Lett. 2007 Feb 20;581(4):644-50. Epub 2007 Jan 18.
21. Growth cone morphology and spreading are regulated by a dynamin-cortactin complex at point contacts in hippocampal neurons. Kurklinsky S, etal., J Neurochem. 2011 Apr;117(1):48-60. doi: 10.1111/j.1471-4159.2011.07169.x. Epub 2011 Feb 9.
22. Novel mechanism of endothelial nitric oxide synthase activation mediated by caveolae internalization in endothelial cells. Maniatis NA, etal., Circ Res. 2006 Oct 13;99(8):870-7. Epub 2006 Sep 14.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. Dynamin 2 cooperates with amphiphysin 1 in phagocytosis in sertoli cells. Nakanishi A, etal., Acta Med Okayama. 2008 Dec;62(6):385-91.
25. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
26. Dynamin isoform-specific interaction with the shank/ProSAP scaffolding proteins of the postsynaptic density and actin cytoskeleton. Okamoto PM, etal., J Biol Chem 2001 Dec 21;276(51):48458-65.
27. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
28. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
29. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
30. Ionizing radiation-induced adenovirus infection is mediated by Dynamin 2. Qian J, etal., Cancer Res. 2005 Jul 1;65(13):5493-7.
31. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
32. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
33. Dimeric endophilin A2 stimulates assembly and GTPase activity of dynamin 2. Ross JA, etal., Biophys J. 2011 Feb 2;100(3):729-37. doi: 10.1016/j.bpj.2010.12.3717.
34. Modulation of Rac localization and function by dynamin. Schlunck G, etal., Mol Biol Cell. 2004 Jan;15(1):256-67. Epub 2003 Nov 14.
35. A Dyn2-CIN85 complex mediates degradative traffic of the EGFR by regulation of late endosomal budding. Schroeder B, etal., EMBO J. 2010 Sep 15;29(18):3039-53. doi: 10.1038/emboj.2010.190. Epub 2010 Aug 13.
36. Regulation of dynamin 2 and G protein-coupled receptor kinase 2 in rat nucleus accumbens during acute and repeated cocaine administration. Schroeder JA, etal., Synapse. 2009 Oct;63(10):863-70. doi: 10.1002/syn.20669.
37. Role of Src-induced dynamin-2 phosphorylation in caveolae-mediated endocytosis in endothelial cells. Shajahan AN, etal., J Biol Chem. 2004 May 7;279(19):20392-400. Epub 2004 Mar 8.
38. Proteomics profiling of nuclear proteins for kidney fibroblasts suggests hypoxia, meiosis, and cancer may meet in the nucleus. Shakib K, etal., Proteomics. 2005 Jul;5(11):2819-38.
39. Differential expression and regulation of multiple dynamins. Sontag JM, etal., J Biol Chem 1994 Feb 11;269(6):4547-54.
40. Role of the proline-rich domain of dynamin-2 and its interactions with Src homology 3 domains during endocytosis of the AT1 angiotensin receptor. Szaszak M, etal., J Biol Chem 2002 Jun 14;277(24):21650-6.
41. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
42. CAP (Cbl associated protein) regulates receptor-mediated endocytosis. Tosoni D and Cestra G, FEBS Lett. 2009 Jan 22;583(2):293-300. doi: 10.1016/j.febslet.2008.12.047. Epub 2008 Dec 29.
43. TTP specifically regulates the internalization of the transferrin receptor. Tosoni D, etal., Cell. 2005 Dec 2;123(5):875-88.
44. Low-level laser irradiation stimulates tenocyte migration with up-regulation of dynamin II expression. Tsai WC, etal., PLoS One. 2012;7(5):e38235. doi: 10.1371/journal.pone.0038235. Epub 2012 May 30.
45. Src kinase regulates the integrity and function of the Golgi apparatus via activation of dynamin 2. Weller SG, etal., Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5863-8. doi: 10.1073/pnas.0915123107. Epub 2010 Mar 15.
46. Expression of the endocytic proteins dynamin and amphiphysin in rat gastric enterochromaffin-like cells. Zanner R, etal., J Cell Sci. 2004 May 1;117(Pt 11):2369-76.
Additional References at PubMed
PMID:10908605   PMID:12646135   PMID:14760703   PMID:14985334   PMID:15696170   PMID:15834155   PMID:16903783   PMID:16938290   PMID:18388313   PMID:19056867   PMID:19605363   PMID:20529869  
PMID:21129155   PMID:21281565   PMID:21423176   PMID:21525035   PMID:21689597   PMID:22451505   PMID:22977238   PMID:23533145   PMID:23687302   PMID:23746204   PMID:23837875   PMID:24710573  
PMID:24824085   PMID:25092467   PMID:25807483   PMID:26296893   PMID:26437238   PMID:27328317   PMID:28553222   PMID:34107845   PMID:36102975  


Genomics

Comparative Map Data
Dnm2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2819,978,313 - 20,060,162 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,978,400 - 20,060,157 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx824,010,157 - 24,091,388 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0822,307,994 - 22,389,225 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0820,208,114 - 20,289,207 (+)NCBIRnor_WKY
Rnor_6.0822,458,869 - 22,540,649 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,458,899 - 22,540,524 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0822,512,875 - 22,594,760 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4820,527,130 - 20,610,749 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1820,527,130 - 20,610,749 (+)NCBI
Celera821,369,673 - 21,450,772 (+)NCBICelera
Cytogenetic Map8q13NCBI
DNM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381910,718,079 - 10,831,903 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1910,718,055 - 10,833,488 (+)EnsemblGRCh38hg38GRCh38
GRCh371910,828,755 - 10,942,579 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,689,755 - 10,803,579 (+)NCBINCBI36Build 36hg18NCBI36
Build 341910,689,754 - 10,803,579NCBI
Celera1910,723,575 - 10,837,431 (+)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef1910,405,937 - 10,520,718 (+)NCBIHuRef
CHM1_11910,829,940 - 10,943,823 (+)NCBICHM1_1
T2T-CHM13v2.01910,844,675 - 10,958,914 (+)NCBIT2T-CHM13v2.0
Dnm2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39921,336,167 - 21,419,055 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl921,336,204 - 21,419,055 (+)EnsemblGRCm39 Ensembl
GRCm38921,424,908 - 21,507,759 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl921,424,908 - 21,507,759 (+)EnsemblGRCm38mm10GRCm38
MGSCv37921,229,389 - 21,311,568 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36921,175,347 - 21,257,526 (+)NCBIMGSCv36mm8
Celera918,693,560 - 18,775,727 (+)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.79NCBI
Dnm2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554951,860,644 - 1,934,818 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554951,860,644 - 1,934,589 (+)NCBIChiLan1.0ChiLan1.0
DNM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11910,974,699 - 11,107,354 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1910,933,672 - 11,106,478 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01910,272,172 - 10,386,032 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
DNM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12050,398,866 - 50,487,303 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2050,398,864 - 50,487,241 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2050,271,460 - 50,359,936 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02050,920,493 - 51,009,858 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2050,919,081 - 51,019,741 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12050,129,310 - 50,218,400 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02050,556,853 - 50,645,731 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02050,798,300 - 50,886,770 (-)NCBIUU_Cfam_GSD_1.0
Dnm2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118209,308,313 - 209,397,278 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936659957,392 - 1,049,188 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936659957,408 - 1,046,393 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl269,474,031 - 69,574,424 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1269,474,011 - 69,574,427 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2269,941,439 - 70,005,977 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DNM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.169,718,014 - 9,830,061 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl69,718,244 - 9,831,206 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607410,123,763 - 10,234,870 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dnm2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248282,727,112 - 2,807,319 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248282,727,136 - 2,805,248 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dnm2
189 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:624
Count of miRNA genes:167
Interacting mature miRNAs:193
Transcripts:ENSRNOT00000010947, ENSRNOT00000065028, ENSRNOT00000066007
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124597739Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125902202Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat

Markers in Region
RH127437  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2820,056,616 - 20,056,804 (+)MAPPERmRatBN7.2
Rnor_6.0822,537,102 - 22,537,289NCBIRnor6.0
Rnor_5.0822,591,213 - 22,591,400UniSTSRnor5.0
RGSC_v3.4820,607,819 - 20,608,006UniSTSRGSC3.4
Celera821,447,842 - 21,448,029UniSTS
RH 3.4 Map8206.01UniSTS
Cytogenetic Map8q13UniSTS
RH94664  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2820,059,135 - 20,059,296 (+)MAPPERmRatBN7.2
Rnor_6.0822,539,621 - 22,539,781NCBIRnor6.0
Rnor_5.0822,593,732 - 22,593,892UniSTSRnor5.0
RGSC_v3.4820,610,338 - 20,610,498UniSTSRGSC3.4
Celera821,450,361 - 21,450,521UniSTS
Cytogenetic Map8q13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_013199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006242608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006242610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006242611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006242612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006242613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006242614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005487746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC130555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L24562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L25605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000010947   ⟹   ENSRNOP00000010948
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl819,978,443 - 20,059,547 (+)Ensembl
Rnor_6.0 Ensembl822,458,933 - 22,540,032 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000065028   ⟹   ENSRNOP00000060296
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl819,978,400 - 20,059,546 (+)Ensembl
Rnor_6.0 Ensembl822,458,996 - 22,539,583 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000066007   ⟹   ENSRNOP00000059940
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl819,978,430 - 20,060,157 (+)Ensembl
Rnor_6.0 Ensembl822,458,899 - 22,540,524 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094915   ⟹   ENSRNOP00000089994
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl819,978,400 - 20,059,546 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000112167   ⟹   ENSRNOP00000077232
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl819,978,443 - 20,059,547 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115745   ⟹   ENSRNOP00000086498
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl819,978,400 - 20,059,546 (+)Ensembl
RefSeq Acc Id: NM_013199   ⟹   NP_037331
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,978,449 - 20,059,547 (+)NCBI
Rnor_6.0822,458,939 - 22,540,032 (+)NCBI
Rnor_5.0822,512,875 - 22,594,760 (+)NCBI
RGSC_v3.4820,527,130 - 20,610,749 (+)RGD
Celera821,369,673 - 21,450,772 (+)RGD
Sequence:
RefSeq Acc Id: XM_006242608   ⟹   XP_006242670
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,978,336 - 20,058,974 (+)NCBI
Rnor_6.0822,458,869 - 22,539,459 (+)NCBI
Rnor_5.0822,512,875 - 22,594,760 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006242610   ⟹   XP_006242672
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,978,335 - 20,059,541 (+)NCBI
Rnor_6.0822,458,869 - 22,540,031 (+)NCBI
Rnor_5.0822,512,875 - 22,594,760 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006242611   ⟹   XP_006242673
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,978,339 - 20,059,541 (+)NCBI
Rnor_6.0822,458,869 - 22,540,031 (+)NCBI
Rnor_5.0822,512,875 - 22,594,760 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006242612   ⟹   XP_006242674
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,978,336 - 20,058,974 (+)NCBI
Rnor_6.0822,458,869 - 22,539,459 (+)NCBI
Rnor_5.0822,512,875 - 22,594,760 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006242613   ⟹   XP_006242675
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,978,340 - 20,058,974 (+)NCBI
Rnor_6.0822,458,869 - 22,539,459 (+)NCBI
Rnor_5.0822,512,875 - 22,594,760 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006242614   ⟹   XP_006242676
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,978,340 - 20,060,162 (+)NCBI
Rnor_6.0822,458,869 - 22,540,649 (+)NCBI
Rnor_5.0822,512,875 - 22,594,760 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039080910   ⟹   XP_038936838
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,978,335 - 20,059,541 (+)NCBI
RefSeq Acc Id: XM_039080911   ⟹   XP_038936839
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,978,332 - 20,058,974 (+)NCBI
RefSeq Acc Id: XM_039080912   ⟹   XP_038936840
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,978,334 - 20,059,541 (+)NCBI
RefSeq Acc Id: XM_039080913   ⟹   XP_038936841
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,978,335 - 20,058,974 (+)NCBI
RefSeq Acc Id: XM_039080915   ⟹   XP_038936843
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,978,334 - 20,060,162 (+)NCBI
RefSeq Acc Id: XM_039080916   ⟹   XP_038936844
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,978,334 - 20,059,541 (+)NCBI
RefSeq Acc Id: XM_039080917   ⟹   XP_038936845
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,978,335 - 20,060,162 (+)NCBI
RefSeq Acc Id: XM_039080918   ⟹   XP_038936846
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,978,339 - 20,060,162 (+)NCBI
RefSeq Acc Id: XM_039080920   ⟹   XP_038936848
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,978,335 - 20,060,162 (+)NCBI
RefSeq Acc Id: XM_039080921   ⟹   XP_038936849
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,978,313 - 20,039,163 (+)NCBI
RefSeq Acc Id: XM_039080922   ⟹   XP_038936850
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2820,030,966 - 20,058,974 (+)NCBI
RefSeq Acc Id: XR_005487746
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,978,318 - 20,033,541 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_037331   ⟸   NM_013199
- UniProtKB: P39052 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006242672   ⟸   XM_006242610
- Peptide Label: isoform X8
- UniProtKB: A0A8I6A1C6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242676   ⟸   XM_006242614
- Peptide Label: isoform X12
- UniProtKB: A0A0A0MY48 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242673   ⟸   XM_006242611
- Peptide Label: isoform X7
- UniProtKB: A0A8I6ADL1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242675   ⟸   XM_006242613
- Peptide Label: isoform X9
- UniProtKB: P39052 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006242670   ⟸   XM_006242608
- Peptide Label: isoform X5
- UniProtKB: P39052 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006242674   ⟸   XM_006242612
- Peptide Label: isoform X10
- UniProtKB: P39052 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000060296   ⟸   ENSRNOT00000065028
RefSeq Acc Id: ENSRNOP00000059940   ⟸   ENSRNOT00000066007
RefSeq Acc Id: ENSRNOP00000010948   ⟸   ENSRNOT00000010947
RefSeq Acc Id: XP_038936849   ⟸   XM_039080921
- Peptide Label: isoform X16
RefSeq Acc Id: XP_038936839   ⟸   XM_039080911
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038936843   ⟸   XM_039080915
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038936840   ⟸   XM_039080912
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038936844   ⟸   XM_039080916
- Peptide Label: isoform X11
RefSeq Acc Id: XP_038936845   ⟸   XM_039080917
- Peptide Label: isoform X13
RefSeq Acc Id: XP_038936848   ⟸   XM_039080920
- Peptide Label: isoform X15
RefSeq Acc Id: XP_038936838   ⟸   XM_039080910
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038936841   ⟸   XM_039080913
- Peptide Label: isoform X4
- UniProtKB: A0A8L2Q4Y6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936846   ⟸   XM_039080918
- Peptide Label: isoform X14
RefSeq Acc Id: XP_038936850   ⟸   XM_039080922
- Peptide Label: isoform X17
RefSeq Acc Id: ENSRNOP00000086498   ⟸   ENSRNOT00000115745
RefSeq Acc Id: ENSRNOP00000089994   ⟸   ENSRNOT00000094915
RefSeq Acc Id: ENSRNOP00000077232   ⟸   ENSRNOT00000112167
Protein Domains
Dynamin-type G   GED   PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P39052-F1-model_v2 AlphaFold P39052 1-870 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695788
Promoter ID:EPDNEW_R6305
Type:initiation region
Name:Dnm2_1
Description:dynamin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0822,458,902 - 22,458,962EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2513 AgrOrtholog
BIND 134466
BioCyc Gene G2FUF-31419 BioCyc
Ensembl Genes ENSRNOG00000007649 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000010948 ENTREZGENE
  ENSRNOP00000010948.6 UniProtKB/TrEMBL
  ENSRNOP00000059940 ENTREZGENE
  ENSRNOP00000059940.3 UniProtKB/TrEMBL
  ENSRNOP00000060296.4 UniProtKB/TrEMBL
  ENSRNOP00000077232 ENTREZGENE
  ENSRNOP00000077232.1 UniProtKB/TrEMBL
  ENSRNOP00000086498 ENTREZGENE
  ENSRNOP00000086498.1 UniProtKB/TrEMBL
  ENSRNOP00000089994 ENTREZGENE
  ENSRNOP00000089994.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010947 ENTREZGENE
  ENSRNOT00000010947.6 UniProtKB/TrEMBL
  ENSRNOT00000065028.5 UniProtKB/TrEMBL
  ENSRNOT00000066007 ENTREZGENE
  ENSRNOT00000066007.5 UniProtKB/TrEMBL
  ENSRNOT00000094915 ENTREZGENE
  ENSRNOT00000094915.1 UniProtKB/TrEMBL
  ENSRNOT00000112167 ENTREZGENE
  ENSRNOT00000112167.1 UniProtKB/TrEMBL
  ENSRNOT00000115745 ENTREZGENE
  ENSRNOT00000115745.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DNM2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynamin_central UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynamin_GTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynamin_GTPase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynamin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynamin_SF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_DYNAMIN_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GED_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25751 UniProtKB/Swiss-Prot
NCBI Gene 25751 ENTREZGENE
PANTHER PTHR11566 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11566:SF23 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Dynamin_M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynamin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dnm2 PhenoGen
PRINTS DYNAMIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_DYNAMIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_DYNAMIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DYNc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC219045
UniProt A0A0A0MY48 ENTREZGENE, UniProtKB/TrEMBL
  A0A0A0MY49_RAT UniProtKB/TrEMBL
  A0A8I5Y7B6_RAT UniProtKB/TrEMBL
  A0A8I6A1C6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ADL1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q4Y6 ENTREZGENE, UniProtKB/TrEMBL
  DYN2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Dnm2  Dynamin 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains posesses an amino-terminal GTPase domain, a central coiled-coil assembly domain, a pleckstrin homology domain, a carboxy terminal coiled -coil region (assembly or GTPase effector domain), a baic proline-rich domain 628513
gene_expression broadly distributed in mnay tissues including brain; enriched presence in postsynaptic density 628513
gene_physical_interaction SRC homology 3 domain-containing proteins, acidic phospholipids and microtubules bind to carboxyl terminal 628513
gene_physical_interaction interacts with Shank/ProSAP family of postsynaptic density scaffolding proteins 628513
gene_process involved in various aspects of membrane trafficking including endocytosis 628513
gene_process may be involved in glutamate receptor down-regulation during postsynaptic membrane turnover 628513
gene_process controls vesicular budding events like synaptic vesicle recycling, receptor-mediated endocytosis, caveolae internalization, phagocytosis and secretory vesicle budding from trans-Golgi network; may be involved in membrane scission 628513
gene_process may also act as a GTPase switch in recruiting endocytic factors 628513
gene_protein 100 kDa 628513
gene_regulation phosphorylation at Ser848 is regulated via dopamine receptor signaling 727418