Dnm2 (dynamin 2) - Rat Genome Database

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Gene: Dnm2 (dynamin 2) Rattus norvegicus
Analyze
Symbol: Dnm2
Name: dynamin 2
RGD ID: 2513
Description: Exhibits several functions, including D2 dopamine receptor binding activity; enzyme binding activity; and protein domain specific binding activity. Involved in several processes, including positive regulation of transport; regulation of plasma membrane bounded cell projection assembly; and regulation of signal transduction. Localizes to several cellular components, including Golgi apparatus subcompartment; cytoplasmic vesicle; and postsynaptic density, intracellular component. Colocalizes with growth cone. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate B; centronuclear myopathy 1; and lethal congenital contracture syndrome. Orthologous to human DNM2 (dynamin 2); PARTICIPATES IN platelet-derived growth factor signaling pathway; syndecan signaling pathway; vascular endothelial growth factor signaling pathway; INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: DYIIAAB; dynamin-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2819,978,313 - 20,060,162 (+)NCBI
Rnor_6.0 Ensembl822,458,899 - 22,540,524 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0822,458,869 - 22,540,649 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0822,512,875 - 22,594,760 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4820,527,130 - 20,610,749 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1820,527,130 - 20,610,749 (+)NCBI
Celera821,369,673 - 21,450,772 (+)NCBICelera
Cytogenetic Map8q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aorta development  (ISO)
cellular response to carbon monoxide  (IEP)
cellular response to dopamine  (IDA)
cellular response to nitric oxide  (IEP)
cellular response to X-ray  (IEP)
coronary vasculature development  (ISO)
dynamin family protein polymerization involved in mitochondrial fission  (IBA)
endocytosis  (IEA,TAS)
G protein-coupled receptor internalization  (IMP)
Golgi to plasma membrane transport  (IMP)
macropinocytosis  (IMP)
membrane fusion  (IBA)
mitochondrial fission  (IBA)
negative regulation of membrane tubulation  (ISO)
negative regulation of non-motile cilium assembly  (IMP)
negative regulation of transforming growth factor beta receptor signaling pathway  (IMP)
neuron projection morphogenesis  (IMP)
phagocytosis  (IEA)
positive regulation of clathrin-dependent endocytosis  (IMP)
positive regulation of endocytosis  (IMP)
positive regulation of lamellipodium assembly  (IMP)
positive regulation of nitric oxide biosynthetic process  (IMP)
positive regulation of P-type sodium:potassium-exchanging transporter activity  (IMP)
positive regulation of phagocytosis  (IMP)
positive regulation of substrate adhesion-dependent cell spreading  (IMP)
postsynaptic neurotransmitter receptor internalization  (IBA)
receptor internalization  (IBA,ISO)
receptor-mediated endocytosis  (IDA,IMP)
regulation of axon extension  (IMP)
regulation of Golgi organization  (IMP)
regulation of Rac protein signal transduction  (IMP)
regulation of synapse structure or activity  (IBA)
response to cocaine  (IEP)
response to light stimulus  (IEP)
spermatogenesis  (IEP)
synaptic vesicle budding from presynaptic endocytic zone membrane  (IBA)
synaptic vesicle endocytosis  (ISO)
transferrin transport  (ISO)
ventricular septum development  (ISO)

References

References - curated
1. Antonescu CN, etal., Traffic. 2008 Jul;9(7):1173-90. doi: 10.1111/j.1600-0854.2008.00755.x. Epub 2008 Apr 24.
2. Cao H, etal., J Cell Sci. 2007 Dec 1;120(Pt 23):4167-77. Epub 2007 Nov 14.
3. Cao H, etal., Mol Biol Cell. 1998 Sep;9(9):2595-609.
4. Cao H, etal., Mol Cell Biol. 2010 Feb;30(3):781-92. doi: 10.1128/MCB.00330-09. Epub 2009 Dec 7.
5. Cao H, etal., Nat Cell Biol. 2005 May;7(5):483-92. Epub 2005 Apr 10.
6. Cestra G, etal., Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1731-6. Epub 2005 Jan 19.
7. Chen-Hwang MC, etal., J Biol Chem 2002 May 17;277(20):17597-604.
8. Cook TA, etal., Proc Natl Acad Sci U S A 1994 Jan 18;91(2):644-8.
9. Di A, etal., Mol Biol Cell. 2003 May;14(5):2016-28. Epub 2003 Feb 21.
10. Efendiev R, etal., J Biol Chem 2002 Nov 15;277(46):44108-14.
11. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. GOA data from the GO Consortium
13. Hartig SM, etal., J Cell Sci. 2009 Jul 1;122(Pt 13):2283-91. doi: 10.1242/jcs.041343. Epub 2009 Jun 9.
14. Hovater MB, etal., Am J Physiol Renal Physiol. 2014 Sep 15;307(6):F727-35. doi: 10.1152/ajprenal.00353.2014. Epub 2014 Aug 6.
15. Hyndman KA, etal., Am J Physiol Renal Physiol. 2011 Apr 13.
16. Iguchi H, etal., Acta Med Okayama. 2002 Aug;56(4):205-9.
17. Ikeuchi Y, etal., Cell Rep. 2013 Sep 12;4(5):879-89. doi: 10.1016/j.celrep.2013.07.042. Epub 2013 Aug 29.
18. Kabbani N, etal., Cell Signal. 2004 Apr;16(4):497-503.
19. Krendel M, etal., FEBS Lett. 2007 Feb 20;581(4):644-50. Epub 2007 Jan 18.
20. Kurklinsky S, etal., J Neurochem. 2011 Apr;117(1):48-60. doi: 10.1111/j.1471-4159.2011.07169.x. Epub 2011 Feb 9.
21. Maniatis NA, etal., Circ Res. 2006 Oct 13;99(8):870-7. Epub 2006 Sep 14.
22. MGD data from the GO Consortium
23. Nakanishi A, etal., Acta Med Okayama. 2008 Dec;62(6):385-91.
24. NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. Okamoto PM, etal., J Biol Chem 2001 Dec 21;276(51):48458-65.
26. OMIM Disease Annotation Pipeline
27. Pipeline to import KEGG annotations from KEGG into RGD
28. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
29. Qian J, etal., Cancer Res. 2005 Jul 1;65(13):5493-7.
30. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. RGD automated import pipeline for gene-chemical interactions
32. Ross JA, etal., Biophys J. 2011 Feb 2;100(3):729-37. doi: 10.1016/j.bpj.2010.12.3717.
33. Schlunck G, etal., Mol Biol Cell. 2004 Jan;15(1):256-67. Epub 2003 Nov 14.
34. Schroeder B, etal., EMBO J. 2010 Sep 15;29(18):3039-53. doi: 10.1038/emboj.2010.190. Epub 2010 Aug 13.
35. Schroeder JA, etal., Synapse. 2009 Oct;63(10):863-70. doi: 10.1002/syn.20669.
36. Shajahan AN, etal., J Biol Chem. 2004 May 7;279(19):20392-400. Epub 2004 Mar 8.
37. Shakib K, etal., Proteomics. 2005 Jul;5(11):2819-38.
38. Sontag JM, etal., J Biol Chem 1994 Feb 11;269(6):4547-54.
39. Szaszak M, etal., J Biol Chem 2002 Jun 14;277(24):21650-6.
40. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
41. Tosoni D and Cestra G, FEBS Lett. 2009 Jan 22;583(2):293-300. doi: 10.1016/j.febslet.2008.12.047. Epub 2008 Dec 29.
42. Tosoni D, etal., Cell. 2005 Dec 2;123(5):875-88.
43. Tsai WC, etal., PLoS One. 2012;7(5):e38235. doi: 10.1371/journal.pone.0038235. Epub 2012 May 30.
44. Weller SG, etal., Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5863-8. doi: 10.1073/pnas.0915123107. Epub 2010 Mar 15.
45. Zanner R, etal., J Cell Sci. 2004 May 1;117(Pt 11):2369-76.
Additional References at PubMed
PMID:10908605   PMID:12646135   PMID:14760703   PMID:14985334   PMID:15696170   PMID:15834155   PMID:16903783   PMID:16938290   PMID:18388313   PMID:19056867   PMID:19605363   PMID:20529869  
PMID:21129155   PMID:21281565   PMID:21423176   PMID:21525035   PMID:21689597   PMID:22451505   PMID:22977238   PMID:23533145   PMID:23687302   PMID:23746204   PMID:23837875   PMID:24710573  
PMID:24824085   PMID:25092467   PMID:25807483   PMID:26296893   PMID:26437238   PMID:27328317   PMID:28553222  


Genomics

Comparative Map Data
Dnm2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2819,978,313 - 20,060,162 (+)NCBI
Rnor_6.0 Ensembl822,458,899 - 22,540,524 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0822,458,869 - 22,540,649 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0822,512,875 - 22,594,760 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4820,527,130 - 20,610,749 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1820,527,130 - 20,610,749 (+)NCBI
Celera821,369,673 - 21,450,772 (+)NCBICelera
Cytogenetic Map8q13NCBI
DNM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1910,718,079 - 10,833,488 (+)EnsemblGRCh38hg38GRCh38
GRCh381910,718,079 - 10,831,903 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371910,828,755 - 10,942,579 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,689,755 - 10,803,579 (+)NCBINCBI36hg18NCBI36
Build 341910,689,754 - 10,803,579NCBI
Celera1910,723,575 - 10,837,431 (+)NCBI
Cytogenetic Map19p13.2NCBI
HuRef1910,405,937 - 10,520,718 (+)NCBIHuRef
CHM1_11910,829,940 - 10,943,823 (+)NCBICHM1_1
Dnm2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39921,336,167 - 21,419,055 (+)NCBIGRCm39mm39
GRCm39 Ensembl921,336,204 - 21,419,055 (+)Ensembl
GRCm38921,424,908 - 21,507,759 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl921,424,908 - 21,507,759 (+)EnsemblGRCm38mm10GRCm38
MGSCv37921,229,389 - 21,311,568 (+)NCBIGRCm37mm9NCBIm37
MGSCv36921,175,347 - 21,257,526 (+)NCBImm8
Celera918,693,560 - 18,775,727 (+)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.79NCBI
Dnm2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554951,860,644 - 1,934,818 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554951,860,644 - 1,934,589 (+)NCBIChiLan1.0ChiLan1.0
DNM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11910,974,699 - 11,107,354 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1910,933,672 - 11,106,478 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01910,272,172 - 10,386,032 (+)NCBIMhudiblu_PPA_v0panPan3
DNM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12050,398,866 - 50,487,303 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2050,398,864 - 50,487,241 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2050,271,460 - 50,359,936 (-)NCBI
ROS_Cfam_1.02050,920,493 - 51,009,858 (-)NCBI
UMICH_Zoey_3.12050,129,310 - 50,218,400 (-)NCBI
UNSW_CanFamBas_1.02050,556,853 - 50,645,731 (-)NCBI
UU_Cfam_GSD_1.02050,798,300 - 50,886,770 (-)NCBI
Dnm2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118209,308,313 - 209,397,278 (-)NCBI
SpeTri2.0NW_004936659957,408 - 1,046,393 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl269,474,031 - 69,574,424 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1269,474,011 - 69,574,427 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2269,941,439 - 70,005,977 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DNM2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.169,718,014 - 9,830,061 (+)NCBI
ChlSab1.1 Ensembl69,718,244 - 9,831,206 (+)Ensembl
Dnm2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248282,727,136 - 2,805,248 (+)NCBI

Position Markers
RH127437  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0822,537,102 - 22,537,289NCBIRnor6.0
Rnor_5.0822,591,213 - 22,591,400UniSTSRnor5.0
RGSC_v3.4820,607,819 - 20,608,006UniSTSRGSC3.4
Celera821,447,842 - 21,448,029UniSTS
RH 3.4 Map8206.01UniSTS
Cytogenetic Map8q13UniSTS
RH94664  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0822,539,621 - 22,539,781NCBIRnor6.0
Rnor_5.0822,593,732 - 22,593,892UniSTSRnor5.0
RGSC_v3.4820,610,338 - 20,610,498UniSTSRGSC3.4
Celera821,450,361 - 21,450,521UniSTS
Cytogenetic Map8q13UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124608226Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125942267Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8210812847108128Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8210812847108128Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8210812847108128Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8210812847108128Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8736807652368076Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8736807652368076Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8736807652368076Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8873867753738677Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)89531047119211942Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)81038843955388439Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)81038843955388439Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810938911120496129Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81137326757541668Rat
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81137350945712344Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81137350945712344Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81144825156448251Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81144825156448251Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81766655562666555Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)82071759265717592Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)82146491991140553Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)821813070100873963Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:624
Count of miRNA genes:167
Interacting mature miRNAs:193
Transcripts:ENSRNOT00000010947, ENSRNOT00000065028, ENSRNOT00000066007
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_013199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006242608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006242610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006242611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006242612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006242613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006242614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005487746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC130555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L24562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L25605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000010947   ⟹   ENSRNOP00000010948
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl822,458,933 - 22,540,032 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000065028   ⟹   ENSRNOP00000060296
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl822,458,996 - 22,539,583 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000066007   ⟹   ENSRNOP00000059940
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl822,458,899 - 22,540,524 (+)Ensembl
RefSeq Acc Id: NM_013199   ⟹   NP_037331
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,978,449 - 20,059,547 (+)NCBI
Rnor_6.0822,458,939 - 22,540,032 (+)NCBI
Rnor_5.0822,512,875 - 22,594,760 (+)NCBI
RGSC_v3.4820,527,130 - 20,610,749 (+)RGD
Celera821,369,673 - 21,450,772 (+)RGD
Sequence:
RefSeq Acc Id: XM_006242608   ⟹   XP_006242670
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,978,336 - 20,058,974 (+)NCBI
Rnor_6.0822,458,869 - 22,539,459 (+)NCBI
Rnor_5.0822,512,875 - 22,594,760 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006242610   ⟹   XP_006242672
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,978,335 - 20,059,541 (+)NCBI
Rnor_6.0822,458,869 - 22,540,031 (+)NCBI
Rnor_5.0822,512,875 - 22,594,760 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006242611   ⟹   XP_006242673
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,978,339 - 20,059,541 (+)NCBI
Rnor_6.0822,458,869 - 22,540,031 (+)NCBI
Rnor_5.0822,512,875 - 22,594,760 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006242612   ⟹   XP_006242674
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,978,336 - 20,058,974 (+)NCBI
Rnor_6.0822,458,869 - 22,539,459 (+)NCBI
Rnor_5.0822,512,875 - 22,594,760 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006242613   ⟹   XP_006242675
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,978,340 - 20,058,974 (+)NCBI
Rnor_6.0822,458,869 - 22,539,459 (+)NCBI
Rnor_5.0822,512,875 - 22,594,760 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006242614   ⟹   XP_006242676
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,978,340 - 20,060,162 (+)NCBI
Rnor_6.0822,458,869 - 22,540,649 (+)NCBI
Rnor_5.0822,512,875 - 22,594,760 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039080910   ⟹   XP_038936838
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,978,335 - 20,059,541 (+)NCBI
RefSeq Acc Id: XM_039080911   ⟹   XP_038936839
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,978,332 - 20,058,974 (+)NCBI
RefSeq Acc Id: XM_039080912   ⟹   XP_038936840
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,978,334 - 20,059,541 (+)NCBI
RefSeq Acc Id: XM_039080913   ⟹   XP_038936841
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,978,335 - 20,058,974 (+)NCBI
RefSeq Acc Id: XM_039080915   ⟹   XP_038936843
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,978,334 - 20,060,162 (+)NCBI
RefSeq Acc Id: XM_039080916   ⟹   XP_038936844
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,978,334 - 20,059,541 (+)NCBI
RefSeq Acc Id: XM_039080917   ⟹   XP_038936845
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,978,335 - 20,060,162 (+)NCBI
RefSeq Acc Id: XM_039080918   ⟹   XP_038936846
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,978,339 - 20,060,162 (+)NCBI
RefSeq Acc Id: XM_039080920   ⟹   XP_038936848
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,978,335 - 20,060,162 (+)NCBI
RefSeq Acc Id: XM_039080921   ⟹   XP_038936849
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,978,313 - 20,039,163 (+)NCBI
RefSeq Acc Id: XM_039080922   ⟹   XP_038936850
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2820,030,966 - 20,058,974 (+)NCBI
RefSeq Acc Id: XR_005487746
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,978,318 - 20,033,541 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_037331   ⟸   NM_013199
- UniProtKB: P39052 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006242672   ⟸   XM_006242610
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_006242676   ⟸   XM_006242614
- Peptide Label: isoform X12
- UniProtKB: A0A0A0MY48 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242673   ⟸   XM_006242611
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_006242675   ⟸   XM_006242613
- Peptide Label: isoform X9
- UniProtKB: P39052 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006242670   ⟸   XM_006242608
- Peptide Label: isoform X5
- UniProtKB: P39052 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006242674   ⟸   XM_006242612
- Peptide Label: isoform X10
- UniProtKB: P39052 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000060296   ⟸   ENSRNOT00000065028
RefSeq Acc Id: ENSRNOP00000059940   ⟸   ENSRNOT00000066007
RefSeq Acc Id: ENSRNOP00000010948   ⟸   ENSRNOT00000010947
RefSeq Acc Id: XP_038936849   ⟸   XM_039080921
- Peptide Label: isoform X16
RefSeq Acc Id: XP_038936839   ⟸   XM_039080911
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038936843   ⟸   XM_039080915
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038936840   ⟸   XM_039080912
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038936844   ⟸   XM_039080916
- Peptide Label: isoform X11
RefSeq Acc Id: XP_038936845   ⟸   XM_039080917
- Peptide Label: isoform X13
RefSeq Acc Id: XP_038936848   ⟸   XM_039080920
- Peptide Label: isoform X15
RefSeq Acc Id: XP_038936838   ⟸   XM_039080910
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038936841   ⟸   XM_039080913
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038936846   ⟸   XM_039080918
- Peptide Label: isoform X14
RefSeq Acc Id: XP_038936850   ⟸   XM_039080922
- Peptide Label: isoform X17
Protein Domains
Dynamin-type G   GED   PH

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695788
Promoter ID:EPDNEW_R6305
Type:initiation region
Name:Dnm2_1
Description:dynamin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0822,458,902 - 22,458,962EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_5.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
8 22590715 22590716 T G snv ACI/EurMcwi (MCW), SR/JrHsd (MCW), FHL/EurMcwi (MCW), FHH/EurMcwi (MCW)


Assembly: RGSC_v3.4
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
8 20607321 20607322 T G snv ACI/EurMcwi (MCW), FHH/EurMcwi (MCW), SS/JrHsdMcwi (MCW), SR/JrHsd (MCW), FHL/EurMcwi (MCW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2513 AgrOrtholog
BIND 134466
Ensembl Genes ENSRNOG00000007649 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000010948 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000059940 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000060296 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010947 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000065028 UniProtKB/TrEMBL
  ENSRNOT00000066007 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DNM2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynamin_central UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynamin_GTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynamin_GTPase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynamin_SF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_DYNAMIN_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GED_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25751 UniProtKB/Swiss-Prot
NCBI Gene 25751 ENTREZGENE
PANTHER PTHR11566 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11566:SF23 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Dynamin_M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynamin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dnm2 PhenoGen
PRINTS DYNAMIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_DYNAMIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_DYNAMIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DYNc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC219045
UniProt A0A0A0MY48 ENTREZGENE, UniProtKB/TrEMBL
  A0A0A0MY49_RAT UniProtKB/TrEMBL
  DYN2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Dnm2  Dynamin 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains posesses an amino-terminal GTPase domain, a central coiled-coil assembly domain, a pleckstrin homology domain, a carboxy terminal coiled -coil region (assembly or GTPase effector domain), a baic proline-rich domain 628513
gene_expression broadly distributed in mnay tissues including brain; enriched presence in postsynaptic density 628513
gene_physical_interaction SRC homology 3 domain-containing proteins, acidic phospholipids and microtubules bind to carboxyl terminal 628513
gene_physical_interaction interacts with Shank/ProSAP family of postsynaptic density scaffolding proteins 628513
gene_process involved in various aspects of membrane trafficking including endocytosis 628513
gene_process may be involved in glutamate receptor down-regulation during postsynaptic membrane turnover 628513
gene_process controls vesicular budding events like synaptic vesicle recycling, receptor-mediated endocytosis, caveolae internalization, phagocytosis and secretory vesicle budding from trans-Golgi network; may be involved in membrane scission 628513
gene_process may also act as a GTPase switch in recruiting endocytic factors 628513
gene_protein 100 kDa 628513
gene_regulation phosphorylation at Ser848 is regulated via dopamine receptor signaling 727418