Drd2 (dopamine receptor D2) - Rat Genome Database

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Gene: Drd2 (dopamine receptor D2) Rattus norvegicus
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Symbol: Drd2
Name: dopamine receptor D2
RGD ID: 2520
Description: Exhibits several functions, including dopamine binding activity; dopamine neurotransmitter receptor activity, coupled via Gi/Go; and ionotropic glutamate receptor binding activity. Involved in several processes, including modulation of chemical synaptic transmission; nervous system development; and regulation of ion transport. Localizes to several cellular components, including cytoplasmic vesicle; integral component of synaptic membrane; and lateral plasma membrane. Used to study cocaine dependence and ovarian hyperstimulation syndrome. Biomarker of several diseases, including Gilles de la Tourette syndrome; drug psychosis; hyperprolactinemia; opiate dependence (multiple); and toxic encephalopathy. Human ortholog(s) of this gene implicated in several diseases, including end stage renal disease; mental depression; migraine with aura; obesity; and type 2 diabetes mellitus. Orthologous to human DRD2 (dopamine receptor D2); PARTICIPATES IN dopamine signaling pathway; excitatory synaptic transmission pathway; dopamine signaling pathway via D2 family of receptors; INTERACTS WITH (+)-butaclamol; (+)-pilocarpine; (R)-noradrenaline.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: D(2) dopamine receptor; dopamine D2 receptor; dopamine receptor 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2849,708,903 - 49,772,888 (+)NCBI
Rnor_6.0 Ensembl853,678,777 - 53,743,642 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0853,678,777 - 53,743,643 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0852,298,097 - 52,363,814 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4852,641,160 - 52,707,749 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1852,660,213 - 52,726,803 (+)NCBI
Celera849,262,252 - 49,324,732 (+)NCBICelera
Cytogenetic Map8q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
alcohol use disorder  (IEA)
Alcoholic Intoxication  (IDA)
Alzheimer's disease  (ISO)
amphetamine abuse  (ISO)
anxiety disorder  (ISO)
attention deficit hyperactivity disorder  (ISO)
basal ganglia disease  (ISO)
Binge-Eating Disorder  (IEP)
Bradycardia  (ISO)
Brain Concussion  (IEP)
Brain Injuries  (IDA)
Brain Injuries, Traumatic  (IEP)
brain ischemia  (IEP)
Catalepsy  (ISO)
cocaine dependence  (IMP)
Cocaine-Related Disorders  (IDA,ISO)
cognitive disorder  (ISO)
dementia  (IEP)
Developmental Disabilities  (ISO)
drug psychosis  (IEP)
Drug-Induced Dyskinesia  (IDA,ISO)
Dyskinesias  (ISO)
dystonia  (ISO)
end stage renal disease  (ISO)
Experimental Arthritis  (IDA,IEP)
Experimental Diabetes Mellitus  (IEP)
Gilles de la Tourette syndrome  (IEP)
heroin dependence  (IEP,ISO)
Huntington's disease  (ISO)
Hyperkinesis  (ISO)
hyperprolactinemia  (IEP,ISO)
hypertension  (ISO)
Hypotension  (ISO)
impulse control disorder  (ISO)
intellectual disability  (ISO)
language disorder  (ISO)
Memory Disorders  (ISO)
mental depression  (IEP,ISO)
migraine with aura  (ISO)
morphine dependence  (IEP)
movement disease  (ISO)
myoclonic dystonia 11  (ISO)
Neuralgia  (IEP,IMP)
obesity  (IEP,ISO)
ovarian hyperstimulation syndrome  (IDA)
Pain  (ISO)
Parkinson's disease  (IEP,ISO)
Parkinsonism  (IDA,ISO)
Pituitary Neoplasms  (ISO)
primary hyperaldosteronism  (ISS)
schizophrenia  (ISO)
substance-related disorder  (ISO)
Tachycardia  (IDA,ISO)
Tobacco Use Disorder  (ISO)
toxic encephalopathy  (IEP)
type 2 diabetes mellitus  (ISO)
visual epilepsy  (ISO)
Weight Gain  (ISO)
withdrawal disorder  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-butaclamol  (EXP)
(+)-pilocarpine  (EXP,ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1S,2R)-5-methoxy-1-methyl-2-(propylamino)tetralin  (ISO)
(R)-lipoic acid  (ISO)
(R)-noradrenaline  (EXP,ISO)
(R,R)-tramadol  (EXP)
(S)-nicotine  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-bromopropane  (EXP)
1-phenyl-1-cyclopentanecarboxylic acid 2-[2-(diethylamino)ethoxy]ethyl ester  (ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine  (EXP,ISO)
3',5'-cyclic AMP  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (EXP,ISO)
3-bromo-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2,6-dimethoxybenzamide  (EXP)
4-hydroxynon-2-enal  (EXP)
6-methoxy-N-[(1-prop-2-enyl-2-pyrrolidinyl)methyl]-2H-benzotriazole-5-carboxamide  (EXP)
8-(3-chlorostyryl)caffeine  (ISO)
acamprosate  (ISO)
aflatoxin B1  (EXP,ISO)
albiflorin  (EXP)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
aluminium atom  (EXP)
aluminium(0)  (EXP)
amisulpride  (EXP)
amitraz  (ISO)
amlodipine  (ISO)
ammonium chloride  (EXP)
amoxapine  (ISO)
amphetamine  (EXP,ISO)
apigenin  (EXP)
apomorphine  (EXP,ISO)
aprindine  (ISO)
aripiprazole  (EXP,ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
barium(0)  (EXP)
Bay-K-8644  (EXP)
benserazide  (EXP)
benzamides  (EXP)
benzimidazoles  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-hexachlorocyclohexane  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bromocriptine  (EXP,ISO)
Bromperidol  (ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP)
caffeine  (EXP,ISO)
calcitriol  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
cannabidiol  (ISO)
cannabigerol  (ISO)
carbamazepine  (EXP)
chlorpromazine  (ISO)
chlorpyrifos  (EXP,ISO)
cinnarizine  (EXP,ISO)
clomipramine  (EXP)
clozapine  (EXP,ISO)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
curcumin  (EXP)
cyanazine  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
decabromodiphenyl ether  (EXP)
diazinon  (EXP)
dibutyl phthalate  (EXP)
dichlorvos  (EXP)
diltiazem  (ISO)
domperidone  (EXP,ISO)
dopamine  (EXP,ISO)
dorsomorphin  (ISO)
ethanol  (EXP,ISO)
felbamate  (EXP)
flunarizine  (EXP,ISO)
fluoxetine  (EXP)
fluphenazine  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gadolinium atom  (EXP)
gamma-hexachlorocyclohexane  (EXP)
haloperidol  (EXP,ISO)
heroin  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
kainic acid  (ISO)
lamotrigine  (ISO)
lanthanum atom  (EXP)
lead diacetate  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
lipoic acid  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
loxapine  (EXP)
lurasidone hydrochloride  (ISO)
maneb  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP,ISO)
manidipine  (ISO)
melatonin  (EXP,ISO)
melevodopa  (EXP)
melittin  (ISO)
mephedrone  (EXP)
methadone  (EXP)
methamphetamine  (EXP,ISO)
methylmercury chloride  (ISO)
methylphenidate  (EXP,ISO)
metoclopramide  (EXP,ISO)
mirtazapine  (EXP)
morphine  (EXP,ISO)
N-(1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-(methylamino)benzamide  (EXP,ISO)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nafadotride  (ISO)
naltrexone  (ISO)
nicotine  (EXP)
nifedipine  (EXP)
nimodipine  (EXP)
nitrogen dioxide  (EXP)
Nonylphenol  (EXP)
olanzapine  (EXP,ISO)
oxidopamine  (EXP)
oxybutynin  (ISO)
Oxypertine  (EXP)
paliperidone palmitate  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
pentetrazol  (ISO)
pentobarbital  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
pergolide  (ISO)
phencyclidine  (ISO)
phenobarbital  (ISO)
piperazines  (EXP)
piperidines  (ISO)
pramipexole  (EXP,ISO)
pregabalin  (ISO)
propamocarb  (ISO)
Propiverine  (ISO)
pyridines  (EXP)
quercetin  (EXP)
quetiapine fumarate  (EXP)
quinolinic acid  (EXP)
quinpirole  (EXP,ISO)
reserpine  (EXP,ISO)
risperidone  (EXP,ISO)
ropinirole  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
SCH 23390  (ISO)
serotonin  (EXP)
simvastatin  (EXP)
SKF 38393  (EXP,ISO)
sodium arsenite  (EXP)
spiperone  (EXP,ISO)
sulpiride  (EXP,ISO)
tacrolimus hydrate  (EXP)
Tautomycin  (EXP)
tetrachloromethane  (EXP,ISO)
tetrahydropalmatine  (ISO)
Tiapamil  (EXP,ISO)
topiramate  (ISO)
tramadol  (EXP)
trichostatin A  (ISO)
valproic acid  (EXP)
verapamil  (ISO)
vorinostat  (ISO)
zinc acetate  (EXP)
zinc atom  (EXP,ISO)
zinc dichloride  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acid secretion  (IDA)
activation of protein kinase activity  (IDA)
adenohypophysis development  (ISO)
adenylate cyclase-activating adrenergic receptor signaling pathway  (IBA)
adenylate cyclase-inhibiting dopamine receptor signaling pathway  (IBA,IDA,ISO)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (IDA)
adult behavior  (ISO)
adult walking behavior  (ISO)
arachidonic acid secretion  (ISO)
associative learning  (ISO)
auditory behavior  (IMP)
autophagy  (IDA)
axonogenesis  (ISO)
behavioral response to cocaine  (ISO)
behavioral response to ethanol  (ISO)
branching morphogenesis of a nerve  (ISO)
cellular potassium ion homeostasis  (IC)
cerebral cortex GABAergic interneuron migration  (ISO)
circadian regulation of gene expression  (ISO)
dopamine metabolic process  (ISO)
dopamine receptor signaling pathway  (IDA,ISO,TAS)
drinking behavior  (IDA)
feeding behavior  (ISO)
forebrain development  (IMP)
G protein-coupled receptor internalization  (IDA)
G protein-coupled receptor signaling pathway  (ISO)
grooming behavior  (ISO)
hyaloid vascular plexus regression  (ISO,ISS)
intracellular signal transduction  (ISO)
locomotory behavior  (IMP,ISO)
long-term memory  (IMP)
modulation of chemical synaptic transmission  (ISO)
negative regulation of adenylate cyclase activity  (IBA,ISO)
negative regulation of blood pressure  (ISO)
negative regulation of cell death  (IDA)
negative regulation of cell migration  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of circadian sleep/wake cycle, sleep  (IDA)
negative regulation of cytosolic calcium ion concentration  (IBA,IMP)
negative regulation of dopamine receptor signaling pathway  (ISO)
negative regulation of dopamine secretion  (IMP)
negative regulation of innate immune response  (ISO)
negative regulation of insulin secretion  (IMP)
negative regulation of protein kinase B signaling  (ISO)
negative regulation of protein phosphorylation  (IMP)
negative regulation of protein secretion  (ISO)
negative regulation of synaptic transmission  (IDA)
negative regulation of synaptic transmission, glutamatergic  (IBA,ISO)
negative regulation of voltage-gated calcium channel activity  (IBA,IDA,ISO)
nervous system process involved in regulation of systemic arterial blood pressure  (ISO)
neuron-neuron synaptic transmission  (ISO)
orbitofrontal cortex development  (IEP)
peristalsis  (ISO)
phospholipase C-activating dopamine receptor signaling pathway  (IBA,ISO)
pigmentation  (ISO)
positive regulation of cytokinesis  (ISO)
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway  (IBA,ISO)
positive regulation of dopamine uptake involved in synaptic transmission  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IMP)
positive regulation of G protein-coupled receptor signaling pathway  (IMP)
positive regulation of glial cell-derived neurotrophic factor production  (ISO)
positive regulation of growth hormone secretion  (ISO)
positive regulation of long-term synaptic potentiation  (IMP)
positive regulation of mitotic nuclear division  (TAS)
positive regulation of multicellular organism growth  (ISO)
positive regulation of neuroblast proliferation  (ISO)
positive regulation of neurogenesis  (IDA)
positive regulation of receptor internalization  (IMP)
positive regulation of renal sodium excretion  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA)
positive regulation of urine volume  (ISO)
postsynaptic modulation of chemical synaptic transmission  (EXP,IDA)
prepulse inhibition  (ISO)
protein localization  (ISO)
regulation of dopamine secretion  (IBA,ISO)
regulation of dopamine uptake involved in synaptic transmission  (ISO)
regulation of heart rate  (ISO)
regulation of locomotion involved in locomotory behavior  (IMP)
regulation of long-term neuronal synaptic plasticity  (ISO)
regulation of MAPK cascade  (IDA)
regulation of neurotransmitter uptake  (ISO)
regulation of phosphoprotein phosphatase activity  (IMP)
regulation of potassium ion transport  (IBA,IDA,ISO)
regulation of sodium ion transport  (ISO)
regulation of synapse structural plasticity  (IDA)
regulation of synaptic transmission, GABAergic  (ISO)
regulation of synaptic vesicle exocytosis  (ISO)
release of sequestered calcium ion into cytosol  (IMP)
response to amphetamine  (IEP,ISO)
response to axon injury  (IEP)
response to cocaine  (ISO)
response to drug  (IDA,ISO)
response to ethanol  (IEP)
response to histamine  (ISO)
response to hypoxia  (IMP)
response to inactivity  (IEP)
response to iron ion  (IEP)
response to light stimulus  (ISO)
response to morphine  (ISO)
response to nicotine  (IEP)
response to toxic substance  (IEP)
sensory perception of smell  (ISO)
startle response  (ISO)
striatum development  (IEP)
synapse assembly  (IEP)
synaptic transmission, dopaminergic  (IEA)
temperature homeostasis  (ISO)
visual learning  (ISO)
Wnt signaling pathway  (IDA)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
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Additional References at PubMed
PMID:1321233   PMID:1331329   PMID:1358063   PMID:1390623   PMID:1980140   PMID:1991517   PMID:2138567   PMID:2480527   PMID:2531656   PMID:2531846   PMID:2531847   PMID:7549459  
PMID:7566118   PMID:7706278   PMID:7921596   PMID:7925842   PMID:8001143   PMID:8294904   PMID:8301582   PMID:8413587   PMID:8666994   PMID:8836575   PMID:9140068   PMID:9169514  
PMID:9247267   PMID:9247268   PMID:9252189   PMID:9354330   PMID:9547254   PMID:9717839   PMID:9886065   PMID:10051229   PMID:10341260   PMID:10471093   PMID:10537166   PMID:10698004  
PMID:10828532   PMID:10908627   PMID:10934242   PMID:10974427   PMID:11015197   PMID:11069937   PMID:11069974   PMID:11089973   PMID:11105945   PMID:11150348   PMID:11160501   PMID:11166059  
PMID:11172060   PMID:11264672   PMID:11303741   PMID:11389175   PMID:11438590   PMID:11557166   PMID:11566895   PMID:11567069   PMID:11861492   PMID:11861790   PMID:11864730   PMID:11897683  
PMID:11914579   PMID:11923462   PMID:11943831   PMID:11973446   PMID:12084937   PMID:12097513   PMID:12145343   PMID:12175868   PMID:12182883   PMID:12185400   PMID:12218708   PMID:12223546  
PMID:12223553   PMID:12417685   PMID:12421350   PMID:12452531   PMID:12476322   PMID:12507943   PMID:12544452   PMID:12576184   PMID:12665504   PMID:12683952   PMID:12818179   PMID:12837020  
PMID:12930822   PMID:12943989   PMID:14523624   PMID:14712229   PMID:15016423   PMID:15033440   PMID:15061865   PMID:15080900   PMID:15197646   PMID:15272078   PMID:15328529   PMID:15489038  
PMID:15716360   PMID:15721235   PMID:15731170   PMID:15857609   PMID:15858065   PMID:15961557   PMID:16000622   PMID:16049099   PMID:16054726   PMID:16136297   PMID:16280031   PMID:16280580  
PMID:16309717   PMID:16413126   PMID:16525059   PMID:16606840   PMID:16715079   PMID:16765459   PMID:16839358   PMID:16959402   PMID:17000016   PMID:17156751   PMID:17194762   PMID:17217413  
PMID:17251429   PMID:17324452   PMID:17327886   PMID:17332411   PMID:17409246   PMID:17426149   PMID:17426594   PMID:17439497   PMID:17512675   PMID:17530188   PMID:17532787   PMID:17544385  
PMID:17706924   PMID:17712281   PMID:17767702   PMID:17850459   PMID:17936656   PMID:18065159   PMID:18097763   PMID:18259092   PMID:18261457   PMID:18279977   PMID:18305460   PMID:18331340  
PMID:18351286   PMID:18367633   PMID:18410175   PMID:18418874   PMID:18486343   PMID:18499630   PMID:18505447   PMID:18554293   PMID:18597076   PMID:18668123   PMID:18671743   PMID:18685027  
PMID:18689859   PMID:18800071   PMID:18847536   PMID:18952607   PMID:18986329   PMID:19038779   PMID:19132528   PMID:19217027   PMID:19275776   PMID:19321949   PMID:19332542   PMID:19374860  
PMID:19536477   PMID:19598174   PMID:19632986   PMID:19703443   PMID:19720148   PMID:19826069   PMID:20034231   PMID:20149807   PMID:20177884   PMID:20179908   PMID:20181611   PMID:20435100  
PMID:20531939   PMID:20554643   PMID:20599592   PMID:20664581   PMID:20888837   PMID:20936685   PMID:20942582   PMID:20962226   PMID:21050459   PMID:21054688   PMID:21113156   PMID:21215744  
PMID:21289195   PMID:21324201   PMID:21389298   PMID:21464994   PMID:21484877   PMID:21593319   PMID:21647367   PMID:21647790   PMID:21856408   PMID:21858872   PMID:21896332   PMID:21903142  
PMID:22022452   PMID:22081646   PMID:22236063   PMID:22308372   PMID:22341870   PMID:22375010   PMID:22384243   PMID:22428025   PMID:22497991   PMID:22564860   PMID:22573829   PMID:22586226  
PMID:22629862   PMID:22650060   PMID:22791651   PMID:22824810   PMID:22888021   PMID:22909302   PMID:23036844   PMID:23151613   PMID:23192317   PMID:23242137   PMID:23286559   PMID:23291154  
PMID:23333674   PMID:23373701   PMID:23399948   PMID:23403122   PMID:23407782   PMID:23443719   PMID:23585124   PMID:23624386   PMID:23632436   PMID:23636617   PMID:23637801   PMID:23701824  
PMID:23727508   PMID:23984873   PMID:24012539   PMID:24032529   PMID:24055909   PMID:24057816   PMID:24120383   PMID:24121738   PMID:24223783   PMID:24236888   PMID:24239691   PMID:24262750  
PMID:24271009   PMID:24529758   PMID:24599469   PMID:24733061   PMID:24823390   PMID:24872568   PMID:24884386   PMID:25172664   PMID:25444866   PMID:25446223   PMID:25735756   PMID:25740916  
PMID:25783380   PMID:25797492   PMID:25823760   PMID:26166189   PMID:26174594   PMID:26192093   PMID:26225746   PMID:26233608   PMID:26256420   PMID:26272445   PMID:26300469   PMID:26345345  
PMID:26446938   PMID:26455877   PMID:26501177   PMID:26509893   PMID:26527415   PMID:26554819   PMID:26662216   PMID:26777117   PMID:26784516   PMID:26911894   PMID:26946126   PMID:27007845  
PMID:27035941   PMID:27155504   PMID:27164043   PMID:27374160   PMID:27392640   PMID:27586561   PMID:27878728   PMID:28009293   PMID:28057528   PMID:28096775   PMID:28154160   PMID:28429261  
PMID:28531297   PMID:28546312   PMID:28673768   PMID:28710248   PMID:28716589   PMID:28734930   PMID:28834708   PMID:28859110   PMID:28887183   PMID:29246771   PMID:29287910   PMID:29292080  
PMID:29498008   PMID:29569008   PMID:30003299   PMID:30092312   PMID:30165079   PMID:30172845   PMID:30343042   PMID:30489132   PMID:30497067   PMID:31029071   PMID:31304635   PMID:31556781  
PMID:31695055   PMID:31917153   PMID:31940660   PMID:31972244   PMID:32087746   PMID:32751703  


Genomics

Candidate Gene Status
Drd2 is a candidate Gene for QTL Alc20
Comparative Map Data
Drd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2849,708,903 - 49,772,888 (+)NCBI
Rnor_6.0 Ensembl853,678,777 - 53,743,642 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0853,678,777 - 53,743,643 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0852,298,097 - 52,363,814 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4852,641,160 - 52,707,749 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1852,660,213 - 52,726,803 (+)NCBI
Celera849,262,252 - 49,324,732 (+)NCBICelera
Cytogenetic Map8q23NCBI
DRD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11113,409,605 - 113,475,691 (-)EnsemblGRCh38hg38GRCh38
GRCh3811113,409,605 - 113,475,398 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711113,280,327 - 113,346,120 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611112,785,527 - 112,851,091 (-)NCBINCBI36hg18NCBI36
Build 3411112,785,527 - 112,851,103NCBI
Celera11110,433,249 - 110,498,937 (-)NCBI
Cytogenetic Map11q23.2NCBI
HuRef11109,208,766 - 109,274,420 (-)NCBIHuRef
CHM1_111113,163,302 - 113,228,980 (-)NCBICHM1_1
Drd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39949,251,633 - 49,319,477 (+)NCBIGRCm39mm39
GRCm39 Ensembl949,251,927 - 49,319,477 (+)Ensembl
GRCm38949,340,360 - 49,408,177 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl949,340,627 - 49,408,177 (+)EnsemblGRCm38mm10GRCm38
MGSCv37949,148,767 - 49,215,319 (+)NCBIGRCm37mm9NCBIm37
MGSCv36949,092,857 - 49,160,407 (+)NCBImm8
Celera946,638,220 - 46,705,025 (+)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map926.72NCBI
Drd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541215,054,038 - 15,114,573 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541215,054,255 - 15,114,558 (-)NCBIChiLan1.0ChiLan1.0
DRD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111112,132,703 - 112,168,583 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11112,132,703 - 112,198,935 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v011108,289,838 - 108,357,174 (-)NCBIMhudiblu_PPA_v0panPan3
DRD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1519,732,842 - 19,795,241 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl519,732,836 - 19,795,241 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha519,704,390 - 19,715,716 (+)NCBI
ROS_Cfam_1.0519,803,212 - 19,815,852 (+)NCBI
UMICH_Zoey_3.1519,865,917 - 19,877,447 (+)NCBI
UNSW_CanFamBas_1.0519,767,231 - 19,778,550 (+)NCBI
UU_Cfam_GSD_1.0519,814,856 - 19,826,385 (+)NCBI
Drd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494795,551,429 - 95,610,929 (-)NCBI
SpeTri2.0NW_0049366121,094,686 - 1,154,149 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DRD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl941,068,779 - 41,133,599 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1941,068,618 - 41,135,262 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2945,883,054 - 45,897,704 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DRD2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11104,774,632 - 104,843,417 (-)NCBI
ChlSab1.1 Ensembl1104,774,180 - 104,842,736 (-)Ensembl
Drd2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247848,828,589 - 8,906,617 (-)NCBI

Position Markers
Drd2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0853,742,522 - 53,743,603NCBIRnor6.0
Rnor_5.0852,362,692 - 52,363,773UniSTSRnor5.0
RGSC_v3.4852,706,629 - 52,707,710UniSTSRGSC3.4
Celera849,323,612 - 49,324,693UniSTS
Cytogenetic Map8q24UniSTS
RH134295  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0853,743,387 - 53,743,593NCBIRnor6.0
Rnor_5.0852,363,557 - 52,363,763UniSTSRnor5.0
RGSC_v3.4852,707,494 - 52,707,700UniSTSRGSC3.4
Celera849,324,477 - 49,324,683UniSTS
RH 3.4 Map8536.6UniSTS
Cytogenetic Map8q24UniSTS
RH144082  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0853,696,369 - 53,696,554NCBIRnor6.0
Rnor_5.0852,316,071 - 52,316,256UniSTSRnor5.0
RGSC_v3.4852,661,026 - 52,661,211UniSTSRGSC3.4
Celera849,279,668 - 49,279,853UniSTS
RH 3.4 Map8535.4UniSTS
Cytogenetic Map8q24UniSTS
MARC_13871-13872:1007494510:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0853,736,680 - 53,737,806NCBIRnor6.0
Rnor_5.0852,356,134 - 52,357,260UniSTSRnor5.0
RGSC_v3.4852,701,340 - 52,702,466UniSTSRGSC3.4
Celera849,318,626 - 49,319,752UniSTS
Cytogenetic Map8q24UniSTS
Drd2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0853,743,295 - 53,743,492NCBIRnor6.0
Rnor_5.0852,363,465 - 52,363,662UniSTSRnor5.0
RGSC_v3.4852,707,402 - 52,707,599UniSTSRGSC3.4
Celera849,324,385 - 49,324,582UniSTS
Cytogenetic Map8q24UniSTS
DRD2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0853,734,314 - 53,735,329NCBIRnor6.0
Rnor_5.0852,353,768 - 52,354,783UniSTSRnor5.0
RGSC_v3.4852,698,974 - 52,699,989UniSTSRGSC3.4
Celera849,316,260 - 49,317,275UniSTS
Cytogenetic Map8q24UniSTS
DRD2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0853,734,278 - 53,735,410NCBIRnor6.0
Rnor_5.0852,353,732 - 52,354,864UniSTSRnor5.0
RGSC_v3.4852,698,938 - 52,700,070UniSTSRGSC3.4
Celera849,316,224 - 49,317,356UniSTS
Cytogenetic Map8q24UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8873867753738677Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)89531047119211942Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)81038843955388439Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)81038843955388439Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810938911120496129Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81137326757541668Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81144825156448251Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81144825156448251Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81766655562666555Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)82071759265717592Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)82146491991140553Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)821813070100873963Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82784149672841496Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)82986798359908353Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)829867983106526740Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)829867983106526740Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)829867983106526740Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)83014480075144800Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)83014480075144800Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)83091811258858224Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)83091811275918112Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)830918112107206309Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)83220198154065241Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)83220198175971421Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)832888352101374135Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83355866062857995Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83355866065717592Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83355866065717592Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83355866065717592Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83355866065717592Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83355866065717592Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83355866065717592Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83355866089058369Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83355866089058369Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83355866089058369Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83355866089058369Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)833558660109028082Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)833558660109028082Rat
1578755Pur5Proteinuria QTL 53.30.0001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)833558660109028082Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)833558764113580387Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83504141480041414Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83592559480925594Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)839230130106506973Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83992790184927901Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83995802284958022Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84421919789542960Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)844219197100873963Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)844458129118087517Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84571234480003418Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84571234490712344Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84571247575971259Rat
5684993Bmd84Bone mineral density QTL 844.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)84658843754065241Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84658843796998640Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)847200750106394378Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)847200750106394378Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)847200750106394378Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)847200750106394378Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)847200750106394378Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)847200750106394378Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)850529480128036471Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)850529480128036471Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)850529480128036471Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)850529480128036471Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)850529563106506973Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:338
Count of miRNA genes:188
Interacting mature miRNAs:225
Transcripts:ENSRNOT00000045944
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hepatobiliary system nervous system renal system reproductive system respiratory system
High
Medium 23
Low 2 8 51 9
Below cutoff 2 12 5 5 5 19 22 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000045944   ⟹   ENSRNOP00000043759
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl853,678,777 - 53,743,642 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000083419   ⟹   ENSRNOP00000074235
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl853,678,994 - 53,743,642 (+)Ensembl
RefSeq Acc Id: NM_012547   ⟹   NP_036679
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2849,708,927 - 49,772,875 (+)NCBI
Rnor_6.0853,678,777 - 53,743,642 (+)NCBI
Rnor_5.0852,298,097 - 52,363,814 (+)NCBI
RGSC_v3.4852,641,160 - 52,707,749 (+)RGD
Celera849,262,252 - 49,324,732 (+)RGD
Sequence:
RefSeq Acc Id: XM_006242979   ⟹   XP_006243041
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2849,708,903 - 49,772,888 (+)NCBI
Rnor_6.0853,678,811 - 53,743,643 (+)NCBI
Rnor_5.0852,298,097 - 52,363,814 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_036679   ⟸   NM_012547
- UniProtKB: P61169 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006243041   ⟸   XM_006242979
- Peptide Label: isoform X1
- UniProtKB: P61169 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000043759   ⟸   ENSRNOT00000045944
RefSeq Acc Id: ENSRNOP00000074235   ⟸   ENSRNOT00000083419

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695941
Promoter ID:EPDNEW_R6466
Type:single initiation site
Name:Drd2_1
Description:dopamine receptor D2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0853,678,791 - 53,678,851EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2520 AgrOrtholog
Ensembl Genes ENSRNOG00000008428 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000043759 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000074235 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000045944 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000083419 UniProtKB/Swiss-Prot
InterPro Dopamine_D2_rcpt UniProtKB/Swiss-Prot
  Dopamine_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report rno:24318 UniProtKB/Swiss-Prot
NCBI Gene 24318 ENTREZGENE
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB DRD2 RGD
PhenoGen Drd2 PhenoGen
PRINTS DOPAMINED2R UniProtKB/Swiss-Prot
  DOPAMINER UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
UniProt DRD2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P13953 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-11-25 Drd2  dopamine receptor D2  Drd2  dopamine receptor 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Drd2  dopamine receptor 2    dopamine receptor D2  Name updated 629478 APPROVED
2002-06-10 Drd2  dopamine receptor D2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mRNA level is high in the hypothalamus in anorectic animals 628466
gene_expression expressed in the brain 628466
gene_function receptor for dopamine 629546
gene_process supresses adenylyl cyclase activity 628466
gene_process plays a role in regulating food intake 628466
gene_protein 443 amino acid, 50 kDa protein 629546