Drd2 (dopamine receptor D2) - Rat Genome Database

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Gene: Drd2 (dopamine receptor D2) Rattus norvegicus
Analyze
Symbol: Drd2
Name: dopamine receptor D2
RGD ID: 2520
Description: Enables several functions, including dopamine binding activity; dopamine neurotransmitter receptor activity, coupled via Gi/Go; and ionotropic glutamate receptor binding activity. Involved in several processes, including modulation of chemical synaptic transmission; nervous system development; and regulation of signal transduction. Located in several cellular components, including cytoplasmic vesicle; lateral plasma membrane; and perikaryon. Is active in GABA-ergic synapse; glutamatergic synapse; and synaptic membrane. Used to study Parkinsonism; cocaine dependence; and ovarian hyperstimulation syndrome. Biomarker of several diseases, including Gilles de la Tourette syndrome; drug psychosis; hyperprolactinemia; opiate dependence (multiple); and toxic encephalopathy. Human ortholog(s) of this gene implicated in several diseases, including depressive disorder; end stage renal disease; migraine with aura; obesity; and type 2 diabetes mellitus. Orthologous to human DRD2 (dopamine receptor D2); PARTICIPATES IN dopamine signaling pathway; excitatory synaptic transmission pathway; dopamine signaling pathway via D2 family of receptors; INTERACTS WITH (+)-butaclamol; (+)-pilocarpine; (R)-noradrenaline.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: D(2) dopamine receptor; dopamine D2 receptor; dopamine receptor 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Alc20
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2849,708,927 - 49,772,876 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl849,708,927 - 49,772,875 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx855,213,102 - 55,276,965 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0853,491,983 - 53,555,839 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0851,356,250 - 51,420,103 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0853,678,777 - 53,743,643 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl853,678,777 - 53,743,642 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0852,298,097 - 52,363,814 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4852,641,160 - 52,707,749 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1852,660,213 - 52,726,803 (+)NCBI
Celera849,262,252 - 49,324,732 (+)NCBICelera
Cytogenetic Map8q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
alcohol use disorder  (IEA)
Alcoholic Intoxication  (IDA)
Alzheimer's disease  (ISO)
amphetamine abuse  (ISO)
anxiety disorder  (ISO)
attention deficit hyperactivity disorder  (ISO)
basal ganglia disease  (ISO)
Binge-Eating Disorder  (IEP)
Bradycardia  (ISO)
Brain Concussion  (IEP)
Brain Injuries  (IDA)
brain ischemia  (IEP)
Catalepsy  (ISO)
Chromosome 11, Partial Trisomy 11q  (ISO)
cocaine dependence  (IMP)
Cocaine-Related Disorders  (IDA,ISO)
cognitive disorder  (ISO)
dementia  (IEP)
depressive disorder  (IEP,ISO)
Developmental Disabilities  (ISO)
drug psychosis  (IEP)
Drug-Induced Dyskinesia  (IDA,ISO)
Dyskinesias  (ISO)
dystonia  (ISO)
end stage renal disease  (ISO)
Experimental Arthritis  (IDA,IEP)
Experimental Diabetes Mellitus  (IEP)
genetic disease  (ISO)
Gilles de la Tourette syndrome  (IEP)
heroin dependence  (IEP,ISO)
Huntington's disease  (ISO)
Hyperkinesis  (ISO)
hyperprolactinemia  (IEP,ISO)
hypertension  (ISO)
Hypotension  (ISO)
impulse control disorder  (ISO)
intellectual disability  (ISO)
language disorder  (ISO)
Memory Disorders  (ISO)
migraine with aura  (ISO)
morphine dependence  (IEP)
movement disease  (ISO)
myoclonic dystonia 11  (ISO)
Neuralgia  (IEP,IMP)
obesity  (IEP,ISO)
ovarian hyperstimulation syndrome  (IDA)
Pain  (ISO)
Parkinson's disease  (IEP,ISO,ISS)
Parkinsonism  (IDA,ISO)
Pituitary Neoplasms  (ISO)
primary hyperaldosteronism  (ISS)
schizophrenia  (ISO)
substance-related disorder  (ISO)
Tachycardia  (IDA,ISO)
Tobacco Use Disorder  (ISO)
toxic encephalopathy  (IEP)
traumatic brain injury  (IEP)
type 2 diabetes mellitus  (ISO)
Weight Gain  (ISO)
withdrawal disorder  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-butaclamol  (EXP)
(+)-pilocarpine  (EXP,ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1S,2R)-5-methoxy-1-methyl-2-(propylamino)tetralin  (ISO)
(R)-lipoic acid  (ISO)
(R)-noradrenaline  (EXP,ISO)
(R,R)-tramadol  (EXP)
(S)-naringenin  (EXP)
(S)-nicotine  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-bromopropane  (EXP)
1-phenyl-1-cyclopentanecarboxylic acid 2-[2-(diethylamino)ethoxy]ethyl ester  (ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine  (EXP,ISO)
3',5'-cyclic AMP  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (EXP,ISO)
3-bromo-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2,6-dimethoxybenzamide  (EXP)
4-hydroxynon-2-enal  (EXP)
6-methoxy-N-[(1-prop-2-enyl-2-pyrrolidinyl)methyl]-2H-benzotriazole-5-carboxamide  (EXP)
8-(3-chlorostyryl)caffeine  (ISO)
acamprosate  (ISO)
aflatoxin B1  (EXP,ISO)
albiflorin  (EXP)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
aluminium atom  (EXP)
aluminium(0)  (EXP)
amisulpride  (EXP)
amitraz  (ISO)
amlodipine  (ISO)
ammonium chloride  (EXP)
amoxapine  (ISO)
amphetamine  (EXP,ISO)
antimycin A  (ISO)
apigenin  (EXP)
apomorphine  (EXP,ISO)
aprindine  (ISO)
arachidonyl-2'-chloroethylamide  (EXP)
aripiprazole  (EXP,ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
Atractylone  (ISO)
atrazine  (EXP)
azoxystrobin  (ISO)
Bardoxolone methyl  (ISO)
barium(0)  (EXP)
Bay-K-8644  (EXP)
benserazide  (EXP)
benzamides  (EXP)
benzimidazoles  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-hexachlorocyclohexane  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bromocriptine  (EXP,ISO)
Bromperidol  (ISO)
C60 fullerene  (EXP)
cabergoline  (ISO)
cadmium atom  (EXP)
caffeine  (EXP,ISO)
calcitriol  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
cannabidiol  (EXP,ISO)
cannabigerol  (ISO)
carbamazepine  (EXP)
CGP 52608  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (EXP,ISO)
cinnarizine  (EXP,ISO)
clomipramine  (EXP)
clozapine  (EXP,ISO)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
curcumin  (EXP)
cyanazine  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
decabromodiphenyl ether  (EXP)
deguelin  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
dichlorvos  (EXP)
diltiazem  (ISO)
dizocilpine  (EXP)
dizocilpine maleate  (ISO)
domperidone  (EXP,ISO)
dopamine  (EXP,ISO)
dorsomorphin  (ISO)
ethanol  (EXP,ISO)
eticlopride(1+)  (EXP,ISO)
felbamate  (EXP)
fenpyroximate  (ISO)
flunarizine  (EXP,ISO)
fluoxetine  (EXP)
fluphenazine  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gadolinium atom  (EXP)
gamma-hexachlorocyclohexane  (EXP)
haloperidol  (EXP,ISO)
heroin  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
kainic acid  (ISO)
ketamine  (EXP)
lamotrigine  (ISO)
lanthanum atom  (EXP)
lead diacetate  (EXP)
lead(0)  (ISO)
lipoic acid  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
loxapine  (EXP)
lurasidone hydrochloride  (ISO)
lysergic acid diethylamide  (EXP)
maneb  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
manidipine  (ISO)
melatonin  (EXP,ISO)
melevodopa  (EXP)
melittin  (ISO)
mephedrone  (EXP)
methadone  (EXP)
methamphetamine  (EXP,ISO)
Methylazoxymethanol acetate  (EXP)
methylmercury chloride  (ISO)
methylphenidate  (EXP,ISO)
metoclopramide  (EXP,ISO)
mirtazapine  (EXP)
morphine  (EXP,ISO)
N-(1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-(methylamino)benzamide  (EXP,ISO)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-Methylspiperone  (EXP)
nafadotride  (ISO)
naltrexone  (ISO)
nicotine  (EXP)
nifedipine  (EXP)
nimodipine  (EXP)
nitrogen dioxide  (EXP)
Nonylphenol  (EXP)
olanzapine  (EXP,ISO)
oxidopamine  (EXP)
oxybutynin  (ISO)
Oxypertine  (EXP)
paliperidone palmitate  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
pentetrazol  (ISO)
pentobarbital  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
pergolide  (ISO)
phencyclidine  (EXP,ISO)
phenobarbital  (ISO)
picoxystrobin  (ISO)
piperazines  (EXP)
piperidines  (ISO)
pramipexole  (EXP,ISO)
pregabalin  (ISO)
propamocarb  (ISO)
Propiverine  (ISO)
pyridines  (EXP)
pyrimidifen  (ISO)
quercetin  (EXP)
quetiapine fumarate  (EXP)
quinolinic acid  (EXP)
quinpirole  (EXP,ISO)
reserpine  (EXP,ISO)
resveratrol  (ISO)
risperidone  (EXP,ISO)
ropinirole  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
SCH 23390  (ISO)
serotonin  (EXP)
simvastatin  (EXP)
SKF 38393  (EXP,ISO)
sodium arsenite  (EXP)
spiperone  (EXP,ISO)
sulpiride  (EXP,ISO)
tacrolimus hydrate  (EXP)
Tautomycin  (EXP)
tebufenpyrad  (ISO)
tetrachloromethane  (EXP,ISO)
tetrahydropalmatine  (ISO)
thifluzamide  (ISO)
tianeptine  (EXP)
Tiapamil  (EXP,ISO)
topiramate  (ISO)
tramadol  (EXP)
trichostatin A  (ISO)
valproic acid  (EXP)
verapamil  (ISO)
vorinostat  (ISO)
zinc acetate  (EXP)
zinc atom  (EXP,ISO)
zinc dichloride  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acid secretion  (IDA)
activation of protein kinase activity  (IDA)
adenohypophysis development  (ISO)
adenylate cyclase-activating adrenergic receptor signaling pathway  (IBA)
adenylate cyclase-inhibiting dopamine receptor signaling pathway  (IBA,IDA,ISO)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (IDA)
adult behavior  (ISO)
adult walking behavior  (ISO)
arachidonic acid secretion  (ISO)
associative learning  (ISO)
auditory behavior  (IMP)
autophagy  (IDA)
axonogenesis  (ISO)
behavioral response to cocaine  (ISO)
behavioral response to ethanol  (ISO)
branching morphogenesis of a nerve  (ISO)
cell migration  (ISO)
cell population proliferation  (ISO)
cerebral cortex GABAergic interneuron migration  (ISO)
circadian regulation of gene expression  (ISO)
dopamine metabolic process  (ISO)
dopamine receptor signaling pathway  (IDA,ISO,TAS)
dopamine uptake involved in synaptic transmission  (ISO)
drinking behavior  (IDA)
epithelial cell proliferation  (ISO)
feeding behavior  (ISO)
forebrain development  (IMP)
G protein-coupled receptor internalization  (IDA)
G protein-coupled receptor signaling pathway  (ISO)
grooming behavior  (ISO)
hyaloid vascular plexus regression  (ISO,ISS)
intracellular potassium ion homeostasis  (IC)
intracellular signal transduction  (ISO)
locomotory behavior  (IMP,ISO)
long-term memory  (IMP)
modulation of chemical synaptic transmission  (ISO)
negative regulation of blood pressure  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cellular response to hypoxia  (IMP)
negative regulation of circadian sleep/wake cycle, sleep  (IDA)
negative regulation of cytosolic calcium ion concentration  (IBA,IMP)
negative regulation of dopamine receptor signaling pathway  (ISO)
negative regulation of dopamine secretion  (IMP)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of innate immune response  (ISO)
negative regulation of insulin secretion  (IMP)
negative regulation of neuron migration  (ISO)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
negative regulation of protein phosphorylation  (IMP)
negative regulation of protein secretion  (ISO)
negative regulation of synaptic transmission  (IDA)
negative regulation of synaptic transmission, glutamatergic  (IBA,ISO)
nervous system process involved in regulation of systemic arterial blood pressure  (ISO)
neuroblast proliferation  (ISO)
neuron migration  (ISO)
neuron-neuron synaptic transmission  (ISO)
orbitofrontal cortex development  (IEP)
peristalsis  (ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
phospholipase C-activating dopamine receptor signaling pathway  (IBA,ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IBA,ISO)
pigmentation  (ISO)
positive regulation of cytokinesis  (ISO)
positive regulation of dopamine uptake involved in synaptic transmission  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IMP)
positive regulation of G protein-coupled receptor signaling pathway  (IMP)
positive regulation of glial cell-derived neurotrophic factor production  (ISO)
positive regulation of growth hormone secretion  (ISO)
positive regulation of long-term synaptic potentiation  (IMP)
positive regulation of mitotic nuclear division  (TAS)
positive regulation of multicellular organism growth  (ISO)
positive regulation of neuroblast proliferation  (ISO)
positive regulation of neurogenesis  (IDA)
positive regulation of receptor internalization  (IMP)
positive regulation of renal sodium excretion  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA)
positive regulation of urine volume  (ISO)
postsynaptic modulation of chemical synaptic transmission  (EXP,IDA)
prepulse inhibition  (ISO)
presynaptic modulation of chemical synaptic transmission  (ISO)
protein localization  (ISO)
regulation of dopamine secretion  (IBA,ISO)
regulation of dopamine uptake involved in synaptic transmission  (ISO)
regulation of heart rate  (ISO)
regulation of locomotion involved in locomotory behavior  (IMP)
regulation of long-term neuronal synaptic plasticity  (ISO)
regulation of MAPK cascade  (IDA)
regulation of neurotransmitter uptake  (ISO)
regulation of phosphoprotein phosphatase activity  (IMP)
regulation of potassium ion transport  (IBA,IDA,ISO)
regulation of sodium ion transport  (ISO)
regulation of synapse structural plasticity  (IDA)
regulation of synaptic transmission, GABAergic  (ISO)
release of sequestered calcium ion into cytosol  (IMP)
response to amphetamine  (IEP,ISO)
response to axon injury  (IEP)
response to cocaine  (ISO)
response to ethanol  (IEP)
response to histamine  (ISO)
response to hypoxia  (IMP)
response to inactivity  (IEP)
response to iron ion  (IEP)
response to light stimulus  (ISO)
response to morphine  (ISO)
response to nicotine  (IEP)
response to toxic substance  (IEP)
response to xenobiotic stimulus  (IDA,ISO)
sensory perception of smell  (ISO)
startle response  (ISO)
striatum development  (IEP)
synapse assembly  (IEP)
temperature homeostasis  (ISO)
visual learning  (ISO)
Wnt signaling pathway  (IDA)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Enhanced dopamine D2 receptor function in hypothalamus and corpus striatum: their role in liver, plasma and in vitro hepatocyte ALDH regulation in ethanol treated rats. Akash KG, etal., J Biomed Sci. 2008 Sep;15(5):623-31. Epub 2008 Jun 7.
2. Localization of dopamine D2 receptors on cholinergic interneurons of the dorsal striatum and nucleus accumbens of the rat. Alcantara AA, etal., Brain Res. 2003 Oct 3;986(1-2):22-9.
3. Ultrastructural evidence for co-localization of dopamine D2 and micro-opioid receptors in the rat dorsolateral striatum. Ambrose LM, etal., Anat Rec A Discov Mol Cell Evol Biol. 2004 Jul;279(1):583-91.
4. Striatal neurochemical changes in transgenic models of Huntington's disease. Ariano MA, etal., J Neurosci Res. 2002 Jun 15;68(6):716-29.
5. Reduced density of dopamine D2-like receptors on peripheral blood lymphocytes in Alzheimer's disease. Barbanti P, etal., Mech Ageing Dev. 2000 Dec 1;120(1-3):65-75.
6. D2 dopamine receptor Taq1A polymorphism, body weight, and dietary intake in type 2 diabetes. Barnard ND, etal., Nutrition. 2009 Jan;25(1):58-65. Epub 2008 Oct 2.
7. The physiology, signaling, and pharmacology of dopamine receptors. Beaulieu JM and Gainetdinov RR, Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8.
8. Dopamine receptors - IUPHAR Review 13. Beaulieu JM, etal., Br J Pharmacol. 2015 Jan;172(1):1-23.
9. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
10. Isolated Flinders Sensitive Line rats have decreased dopamine D2 receptor mRNA. Bjornebekk A, etal., Neuroreport. 2007 Jul 2;18(10):1039-43.
11. Cocaine self-administration produces a persistent increase in dopamine D2 High receptors. Briand LA, etal., Eur Neuropsychopharmacol. 2008 Aug;18(8):551-6. Epub 2008 Mar 4.
12. Cloning and expression of a rat D2 dopamine receptor cDNA. Bunzow JR, etal., Nature 1988 Dec 22-29;336(6201):783-7.
13. mRNA D(2) dopaminergic receptor expression after hypoxia-ischemia in rat immature brain. Cantagrel S, etal., Biol Neonate. 2001 Jul;80(1):68-73.
14. Dopamine D2 receptor modulation of carotid body type 1 cell intracellular calcium in developing rats. Carroll JL, etal., Am J Physiol Lung Cell Mol Physiol. 2005 May;288(5):L910-6. Epub 2005 Jan 28.
15. Transfected D2 short dopamine receptors inhibit voltage-dependent potassium current in neuroblastoma x glioma hybrid (NG108-15) cells. Castellano MA, etal., Mol Pharmacol. 1993 Sep;44(3):649-56.
16. Polysialic acid is required for dopamine D2 receptor-mediated plasticity involving inhibitory circuits of the rat medial prefrontal cortex. Castillo-Gomez E, etal., PLoS One. 2011;6(12):e29516. Epub 2011 Dec 28.
17. Cognitive impairment and gene expression alterations in a rodent model of binge eating disorder. Chawla A, etal., Physiol Behav. 2017 Oct 15;180:78-90. doi: 10.1016/j.physbeh.2017.08.004. Epub 2017 Aug 15.
18. High and low doses of cocaine intake are differentially regulated by dopamine D2 receptors in the ventral tegmental area and the nucleus accumbens. Chen R, etal., Neurosci Lett. 2018 Feb 14;671:133-139. doi: 10.1016/j.neulet.2018.02.026.
19. Activation of heterologously expressed D3 dopamine receptors: comparison with D2 dopamine receptors. Chio CL, etal., Mol Pharmacol. 1994 Jan;45(1):51-60.
20. Aberrant cortical synaptic plasticity and dopaminergic dysfunction in a mouse model of Huntington's disease. Cummings DM, etal., Hum Mol Genet. 2006 Oct 1;15(19):2856-68. Epub 2006 Aug 11.
21. Conditioned locomotion induced by unilateral intrastriatal administration of apomorphine: D(2) receptor activation is critical but not the expression of the unconditioned response. Dias FR, etal., Brain Res. 2006 Apr 14;1083(1):85-95. Epub 2006 Mar 10.
22. The CRF1 receptor antagonist, antalarmin, reverses isolation-induced up-regulation of dopamine D2 receptors in the amygdala and nucleus accumbens of fawn-hooded rats. Djouma E, etal., Eur J Neurosci. 2006 Jun;23(12):3319-27.
23. Altered dopamine receptor and dopamine transporter binding and tyrosine hydroxylase mRNA expression following perinatal NMDA receptor blockade. du Bois TM, etal., Neurochem Res. 2008 Jul;33(7):1224-31. Epub 2008 Feb 8.
24. Respective roles of dopamine D2 and D3 receptors in food-seeking behaviour in rats. Duarte C, etal., Psychopharmacology (Berl) 2003 Feb;166(1):19-32.
25. Developmental changes in the mRNA expression of neuropeptides and dopamine and glutamate receptors in neonates and adult rats after ventral hippocampal lesion. El-Rawas R, etal., Schizophr Res. 2009 Jun 3.
26. An affected pedigree member analysis of linkage between the dopamine D2 receptor gene TaqI polymorphism and obesity and hypertension. Fang YJ, etal., Int J Cardiol. 2005 Jun 22;102(1):111-6.
27. Lentiviral-mediated gene delivery reveals distinct roles of nucleus accumbens dopamine D2 and D3 receptors in novelty- and light-induced locomotor activity. Fernandes AR, etal., Eur J Neurosci. 2012 Apr;35(8):1344-53. doi: 10.1111/j.1460-9568.2012.08028.x. Epub 2012 Mar 7.
28. Dopamine receptor 2 activation inhibits ovarian vascular endothelial growth factor secretion in an ovarian hyperstimulation syndrome (OHSS) animal model: implications for treatment of OHSS with dopamine receptor 2 agonists. Ferrero H, etal., Fertil Steril. 2014 Nov;102(5):1468-1476.e1. doi: 10.1016/j.fertnstert.2014.07.1240. Epub 2014 Sep 11.
29. Cocaine-induced sex differences in D1 receptor activation and binding levels after acute cocaine administration. Festa ED, etal., Brain Res Bull. 2006 Jan 15;68(4):277-84. Epub 2005 Sep 23.
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46. Association of a missense change in the D2 dopamine receptor with myoclonus dystonia. Klein C, etal., Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):5173-6.
47. Dopamine receptor mechanisms mediate corticotropin-releasing factor-induced long-term potentiation in the rat amygdala following cocaine withdrawal. Krishnan B, etal., Eur J Neurosci. 2010 Mar;31(6):1027-42. Epub 2010 Mar 8.
48. Sound sequence discrimination learning motivated by reward requires dopaminergic D2 receptor activation in the rat auditory cortex. Kudoh M and Shibuki K, Learn Mem. 2006 Nov-Dec;13(6):690-8.
49. Loss of intracellular dystrophin: a potential mechanism for myocardial reperfusion injury. Kyoi S, etal., Circ J. 2003 Aug;67(8):725-7.
50. Central dopaminergic origin of bromocriptine induced tachycardia in normotensive rats. Lahlou S, etal., Cardiovasc Res. 1993 Nov;27(11):2022-7.
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52. The usefulness of the spontaneously hypertensive rat to model attention-deficit/hyperactivity disorder (ADHD) may be explained by the differential expression of dopamine-related genes in the brain. Li Q, etal., Neurochem Int. 2007 May;50(6):848-57. Epub 2007 Mar 1.
53. Changes in Expression of Dopamine, Its Receptor, and Transporter in Nucleus Accumbens of Heroin-Addicted Rats with Brain-Derived Neurotrophic Factor (BDNF) Overexpression. Li Y, etal., Med Sci Monit. 2017 Jun 9;23:2805-2815.
54. Melatonin reduces the neuronal loss, downregulation of dopamine transporter, and upregulation of D2 receptor in rotenone-induced parkinsonian rats. Lin CH, etal., J Pineal Res. 2008 Mar;44(2):205-13.
55. Activation of Go-coupled dopamine D2 receptors inhibits ERK1/ERK2 in pituitary cells. A key step in the transcriptional suppression of the prolactin gene. Liu JC, etal., J Biol Chem. 2002 Sep 27;277(39):35819-25. Epub 2002 Jul 16.
56. Modulation of D2R-NR2B interactions in response to cocaine. Liu XY, etal., Neuron. 2006 Dec 7;52(5):897-909.
57. Novel interaction of the dopamine D2 receptor and the Ca2+ binding protein S100B: role in D2 receptor function. Liu Y, etal., Mol Pharmacol. 2008 Aug;74(2):371-8. Epub 2008 Apr 29.
58. Effects of immobilization stress on neurochemical markers in the motivational system of the male rat. Lucas LR, etal., Brain Res. 2007 Jun 25;1155:108-15. Epub 2007 Apr 27.
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60. Effects of ningdong granule on DA, DRD2, and HVA in a rat model of Tourette's syndrome. Lv H, etal., J Tradit Chin Med. 2012 Jun;32(2):283-8.
61. Preferential Interaction between the dopamine D2 receptor and Arrestin2 in neostriatal neurons. Macey TA, etal., Mol Pharmacol. 2004 Dec;66(6):1635-42. Epub 2004 Sep 10.
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63. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
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65. Dopamine-induced protection against indomethacin-evoked intestinal lesions in rats--role of anti-intestinal motility mediated by D2 receptors. Miyazawa T, etal., Med Sci Monit 2003 Feb;9(2):BR71-7.
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72. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
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89. Polymorphism in exon 6 of the dopamine D(2) receptor gene (DRD2) is associated with elevated blood pressure and personality disorders in men. Rosmond R, etal., J Hum Hypertens. 2001 Aug;15(8):553-8.
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98. Activation of the canonical Wnt pathway by the antipsychotics haloperidol and clozapine involves dishevelled-3. Sutton LP, etal., J Neurochem. 2007 Jul;102(1):153-69. Epub 2007 May 1.
99. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
100. Modulation of Postnatal Neurogenesis by Perinatal Asphyxia: Effect of D1and D2Dopamine Receptor Agonists. Tapia-Bustos A, etal., Neurotox Res. 2017 Jan;31(1):109-121. doi: 10.1007/s12640-016-9669-6. Epub 2016 Sep 16.
101. Differential regional and dose-related effects of asenapine on dopamine receptor subtypes. Tarazi FI, etal., Psychopharmacology (Berl). 2008 May;198(1):103-11. Epub 2008 Feb 24.
102. DRD2 gene transfer into the nucleus accumbens core of the alcohol preferring and nonpreferring rats attenuates alcohol drinking. Thanos PK, etal., Alcohol Clin Exp Res. 2004 May;28(5):720-8.
103. Dopamine-glutamate interactions controlling prefrontal cortical pyramidal cell excitability involve multiple signaling mechanisms. Tseng KY and O'Donnell P, J Neurosci. 2004 Jun 2;24(22):5131-9. doi: 10.1523/JNEUROSCI.1021-04.2004.
104. Dopamine D2 receptor expression is altered by changes in cellular iron levels in PC12 cells and rat brain tissue. Unger EL, etal., J Nutr. 2008 Dec;138(12):2487-94.
105. Differential coupling of dopaminergic D2 receptors expressed in different cell types. Stimulation of phosphatidylinositol 4,5-bisphosphate hydrolysis in LtK- fibroblasts, hyperpolarization, and cytosolic-free Ca2+ concentration decrease in GH4C1 cells. Vallar L, etal., J Biol Chem. 1990 Jun 25;265(18):10320-6.
106. Maternal deprivation and handling modify the effect of the dopamine D3 receptor agonist, BP 897 on morphine-conditioned place preference in rats. Vazquez V, etal., Psychopharmacology (Berl). 2007 Sep;193(4):475-86. Epub 2007 May 10.
107. The role of the dopamine D2 receptor in descending control of pain induced by motor cortex stimulation in the neuropathic rat. Viisanen H, etal., Brain Res Bull. 2012 Nov 1;89(3-4):133-43. doi: 10.1016/j.brainresbull.2012.08.002. Epub 2012 Aug 9.
108. Studies on the regulatory effect of Peony-Glycyrrhiza Decoction on prolactin hyperactivity and underlying mechanism in hyperprolactinemia rat model. Wang D, etal., Neurosci Lett. 2015 Oct 8;606:60-5. doi: 10.1016/j.neulet.2015.08.024. Epub 2015 Aug 18.
109. [Effect of Bushen Huoxue Decoction on dopamine D2 receptor in the brain of rats with Parkinson's disease]. Wang HM, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2011 Nov;31(11):1879-81.
110. A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation. Wang JD, etal., Autophagy. 2015 Nov 2;11(11):2057-2073. doi: 10.1080/15548627.2015.1100930.
111. Schizophrenia, amphetamine-induced sensitized state and acute amphetamine exposure all show a common alteration: increased dopamine D2 receptor dimerization. Wang M, etal., Mol Brain. 2010 Sep 2;3:25.
112. Extremely low-frequency electromagnetic field exposure during chronic morphine treatment strengthens downregulation of dopamine D2 receptors in rat dorsal hippocampus after morphine withdrawal. Wang X, etal., Neurosci Lett. 2008 Mar 15;433(3):178-82. Epub 2008 Jan 10.
113. Endosomal location of dopamine receptors in neuronal cell cytoplasm. Wolstencroft EC, etal., J Mol Histol. 2007 Aug;38(4):333-40. Epub 2007 Jun 26.
114. D1- and D2-like dopamine receptors are co-localized on the presynaptic varicosities of striatal and nucleus accumbens neurons in vitro. Wong AC, etal., Neuroscience. 1999 Mar;89(1):221-33.
115. Identification of glucose-dependant insulin secretion targets in pancreatic beta cells by combining defined-mechanism compound library screening and siRNA gene silencing. Wu W, etal., J Biomol Screen. 2008 Feb;13(2):128-34. Epub 2008 Jan 23.
116. betagamma Dimers mediate synergy of dopamine D2 and adenosine A2 receptor-stimulated PKA signaling and regulate ethanol consumption. Yao L, etal., Cell. 2002 Jun 14;109(6):733-43.
117. Strain differences in the distribution of dopamine (DA-2 and DA-3) receptor sites in rat brain. Yaroslavsky I, etal., Life Sci. 2006 Jul 17;79(8):772-6. Epub 2006 Mar 30.
118. 11C-NMSP/ 18F-FDG microPET to monitor neural stem cell transplantation in a rat model of traumatic brain injury. Zhang H, etal., Eur J Nucl Med Mol Imaging. 2008 Sep;35(9):1699-708. Epub 2008 May 29.
119. Effects of enteral nutrition on the barrier function of the intestinal mucosa and dopamine receptor expression in rats with traumatic brain injury. Zhang X and Jiang X, JPEN J Parenter Enteral Nutr. 2015 Jan;39(1):114-23. doi: 10.1177/0148607113501881. Epub 2013 Sep 18.
120. Inhibition of protein tyrosine/mitogen-activated protein kinase phosphatase activity is associated with D2 dopamine receptor supersensitivity in a rat model of Parkinson's disease. Zhen X, etal., Mol Pharmacol 2002 Dec;62(6):1356-63.
121. Stress-induced depressive behaviors are correlated with Par-4 and DRD2 expression in rat striatum. Zhu X, etal., Behav Brain Res. 2011 Oct 1;223(2):329-35. Epub 2011 May 8.
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Genomics

Comparative Map Data
Drd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2849,708,927 - 49,772,876 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl849,708,927 - 49,772,875 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx855,213,102 - 55,276,965 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0853,491,983 - 53,555,839 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0851,356,250 - 51,420,103 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0853,678,777 - 53,743,643 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl853,678,777 - 53,743,642 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0852,298,097 - 52,363,814 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4852,641,160 - 52,707,749 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1852,660,213 - 52,726,803 (+)NCBI
Celera849,262,252 - 49,324,732 (+)NCBICelera
Cytogenetic Map8q23NCBI
DRD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811113,409,605 - 113,475,398 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11113,409,605 - 113,475,691 (-)EnsemblGRCh38hg38GRCh38
GRCh3711113,280,327 - 113,346,120 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611112,785,527 - 112,851,091 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411112,785,527 - 112,851,103NCBI
Celera11110,433,249 - 110,498,937 (-)NCBICelera
Cytogenetic Map11q23.2NCBI
HuRef11109,208,766 - 109,274,420 (-)NCBIHuRef
CHM1_111113,163,302 - 113,228,980 (-)NCBICHM1_1
T2T-CHM13v2.011113,420,107 - 113,485,882 (-)NCBIT2T-CHM13v2.0
Drd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39949,251,703 - 49,319,468 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl949,251,927 - 49,319,477 (+)EnsemblGRCm39 Ensembl
GRCm38949,340,360 - 49,408,177 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl949,340,627 - 49,408,177 (+)EnsemblGRCm38mm10GRCm38
MGSCv37949,148,767 - 49,215,319 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36949,092,857 - 49,160,407 (+)NCBIMGSCv36mm8
Celera946,638,220 - 46,705,025 (+)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map926.72NCBI
Drd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541215,054,038 - 15,114,573 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541215,054,255 - 15,114,558 (-)NCBIChiLan1.0ChiLan1.0
DRD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan111115,248,609 - 115,315,908 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011108,289,838 - 108,357,174 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111112,132,703 - 112,168,583 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11112,132,703 - 112,198,935 (-)Ensemblpanpan1.1panPan2
DRD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1519,732,842 - 19,795,241 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl519,732,836 - 19,795,241 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha519,704,390 - 19,715,716 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0519,803,212 - 19,815,852 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl519,754,070 - 19,815,870 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1519,865,917 - 19,877,447 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0519,767,231 - 19,778,550 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0519,814,856 - 19,826,385 (+)NCBIUU_Cfam_GSD_1.0
Drd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494795,551,429 - 95,610,929 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366121,094,680 - 1,154,798 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366121,094,686 - 1,154,149 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DRD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl941,068,779 - 41,133,599 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1941,068,618 - 41,135,262 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2945,883,054 - 45,897,704 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DRD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11104,774,632 - 104,843,417 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1104,774,180 - 104,842,736 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604321,144,996 - 21,236,456 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Drd2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247848,827,006 - 8,865,529 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247848,828,589 - 8,906,617 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Drd2
194 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:338
Count of miRNA genes:188
Interacting mature miRNAs:225
Transcripts:ENSRNOT00000045944
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)82720571554998217Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)82824291253961020Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82950266550095447Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815458482492Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84186701070386132Rat
5684993Bmd84Bone mineral density QTL 844.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)84269268450095447Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat

Markers in Region
Drd2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2849,771,754 - 49,772,836 (+)MAPPERmRatBN7.2
Rnor_6.0853,742,522 - 53,743,603NCBIRnor6.0
Rnor_5.0852,362,692 - 52,363,773UniSTSRnor5.0
RGSC_v3.4852,706,629 - 52,707,710UniSTSRGSC3.4
Celera849,323,612 - 49,324,693UniSTS
Cytogenetic Map8q24UniSTS
RH134295  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2849,772,619 - 49,772,826 (+)MAPPERmRatBN7.2
Rnor_6.0853,743,387 - 53,743,593NCBIRnor6.0
Rnor_5.0852,363,557 - 52,363,763UniSTSRnor5.0
RGSC_v3.4852,707,494 - 52,707,700UniSTSRGSC3.4
Celera849,324,477 - 49,324,683UniSTS
RH 3.4 Map8536.6UniSTS
Cytogenetic Map8q24UniSTS
RH144082  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2849,726,430 - 49,726,616 (+)MAPPERmRatBN7.2
Rnor_6.0853,696,369 - 53,696,554NCBIRnor6.0
Rnor_5.0852,316,071 - 52,316,256UniSTSRnor5.0
RGSC_v3.4852,661,026 - 52,661,211UniSTSRGSC3.4
Celera849,279,668 - 49,279,853UniSTS
RH 3.4 Map8535.4UniSTS
Cytogenetic Map8q24UniSTS
MARC_13871-13872:1007494510:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2849,766,710 - 49,767,837 (+)MAPPERmRatBN7.2
Rnor_6.0853,736,680 - 53,737,806NCBIRnor6.0
Rnor_5.0852,356,134 - 52,357,260UniSTSRnor5.0
RGSC_v3.4852,701,340 - 52,702,466UniSTSRGSC3.4
Celera849,318,626 - 49,319,752UniSTS
Cytogenetic Map8q24UniSTS
Drd2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2849,772,527 - 49,772,725 (+)MAPPERmRatBN7.2
Rnor_6.0853,743,295 - 53,743,492NCBIRnor6.0
Rnor_5.0852,363,465 - 52,363,662UniSTSRnor5.0
RGSC_v3.4852,707,402 - 52,707,599UniSTSRGSC3.4
Celera849,324,385 - 49,324,582UniSTS
Cytogenetic Map8q24UniSTS
DRD2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2849,764,342 - 49,765,360 (+)MAPPERmRatBN7.2
Rnor_6.0853,734,314 - 53,735,329NCBIRnor6.0
Rnor_5.0852,353,768 - 52,354,783UniSTSRnor5.0
RGSC_v3.4852,698,974 - 52,699,989UniSTSRGSC3.4
Celera849,316,260 - 49,317,275UniSTS
Cytogenetic Map8q24UniSTS
DRD2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2849,764,306 - 49,765,441 (+)MAPPERmRatBN7.2
Rnor_6.0853,734,278 - 53,735,410NCBIRnor6.0
Rnor_5.0852,353,732 - 52,354,864UniSTSRnor5.0
RGSC_v3.4852,698,938 - 52,700,070UniSTSRGSC3.4
Celera849,316,224 - 49,317,356UniSTS
Cytogenetic Map8q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hepatobiliary system nervous system renal system reproductive system respiratory system
High
Medium 23
Low 2 8 51 9
Below cutoff 2 12 5 5 5 19 22 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000045944   ⟹   ENSRNOP00000043759
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl849,708,927 - 49,772,875 (+)Ensembl
Rnor_6.0 Ensembl853,678,777 - 53,743,642 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000083419   ⟹   ENSRNOP00000074235
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl849,709,143 - 49,772,875 (+)Ensembl
Rnor_6.0 Ensembl853,678,994 - 53,743,642 (+)Ensembl
RefSeq Acc Id: NM_001409379   ⟹   NP_001396308
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2849,708,927 - 49,772,876 (+)NCBI
RefSeq Acc Id: NM_012547   ⟹   NP_036679
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2849,708,927 - 49,772,876 (+)NCBI
Rnor_6.0853,678,777 - 53,743,642 (+)NCBI
Rnor_5.0852,298,097 - 52,363,814 (+)NCBI
RGSC_v3.4852,641,160 - 52,707,749 (+)RGD
Celera849,262,252 - 49,324,732 (+)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_036679   ⟸   NM_012547
- Peptide Label: isoform 1
- UniProtKB: P61169 (UniProtKB/Swiss-Prot),   A6J4B7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000043759   ⟸   ENSRNOT00000045944
RefSeq Acc Id: ENSRNOP00000074235   ⟸   ENSRNOT00000083419
RefSeq Acc Id: NP_001396308   ⟸   NM_001409379
- Peptide Label: isoform 2
- UniProtKB: A6J4B8 (UniProtKB/TrEMBL)
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P61169-F1-model_v2 AlphaFold P61169 1-444 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2520 AgrOrtholog
BioCyc Gene G2FUF-30584 BioCyc
Ensembl Genes ENSRNOG00000008428 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000043759 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000074235 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000045944 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000083419 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Dopamine_D2_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dopamine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24318 UniProtKB/Swiss-Prot
NCBI Gene 24318 ENTREZGENE
PANTHER ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  D(2) DOPAMINE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB DRD2 RGD
PhenoGen Drd2 PhenoGen
PRINTS DOPAMINED2R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DOPAMINER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6J4B7 ENTREZGENE, UniProtKB/TrEMBL
  A6J4B8 ENTREZGENE, UniProtKB/TrEMBL
  DRD2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P13953 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-11-25 Drd2  dopamine receptor D2  Drd2  dopamine receptor 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Drd2  dopamine receptor 2    dopamine receptor D2  Name updated 629478 APPROVED
2002-06-10 Drd2  dopamine receptor D2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mRNA level is high in the hypothalamus in anorectic animals 628466
gene_expression expressed in the brain 628466
gene_function receptor for dopamine 629546
gene_process supresses adenylyl cyclase activity 628466
gene_process plays a role in regulating food intake 628466
gene_protein 443 amino acid, 50 kDa protein 629546