Amph (amphiphysin) - Rat Genome Database

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Gene: Amph (amphiphysin) Rattus norvegicus
Analyze
Symbol: Amph (Ensembl: LOC100910792)
Name: amphiphysin (Ensembl:amphiphysin-like)
RGD ID: 620274
Description: Enables phosphatase binding activity. Involved in positive regulation of endocytosis. Located in axon terminus. Is extrinsic component of synaptic vesicle membrane. Orthologous to human AMPH (amphiphysin); PARTICIPATES IN Fc gamma receptor mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Amph1; amphiphysin 1; amphiphysin-like; LOC100909679; LOC687233; similar to amphiphysin 1; uncharacterized protein LOC100909679
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81750,435,018 - 50,678,583 (-)NCBIGRCr8
mRatBN7.21745,739,385 - 45,982,905 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1745,739,395 - 45,983,315 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1748,180,900 - 48,690,815 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01752,949,166 - 53,178,746 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01747,057,349 - 47,292,588 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01748,304,324 - 48,562,838 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1748,304,322 - 48,562,905 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01746,357,604 - 46,621,763 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41753,558,804 - 53,802,936NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11753,561,655 - 53,805,777NCBI
Cytogenetic Map17q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Syndapin I and endophilin I bind overlapping proline-rich regions of dynamin I: role in synaptic vesicle endocytosis. Anggono V and Robinson PJ, J Neurochem. 2007 Aug;102(3):931-43. Epub 2007 Apr 16.
2. Dynamin is a minibrain kinase/dual specificity Yak1-related kinase 1A substrate. Chen-Hwang MC, etal., J Biol Chem 2002 May 17;277(20):17597-604.
3. Decreased synaptic vesicle recycling efficiency and cognitive deficits in amphiphysin 1 knockout mice. Di Paolo G, etal., Neuron 2002 Feb 28;33(5):789-804.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosis. Lai MM, etal., J Biol Chem. 2000 Nov 3;275(44):34017-20.
6. Amphiphysin, a novel protein associated with synaptic vesicles. Lichte B, etal., EMBO J. 1992 Jul;11(7):2521-30.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Synaptojanin forms two separate complexes in the nerve terminal. Interactions with endophilin and amphiphysin. Micheva KD, etal., J Biol Chem. 1997 Oct 24;272(43):27239-45. doi: 10.1074/jbc.272.43.27239.
9. Dynamin 2 cooperates with amphiphysin 1 in phagocytosis in sertoli cells. Nakanishi A, etal., Acta Med Okayama. 2008 Dec;62(6):385-91.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Identification and characterization of a synaptojanin 2 splice isoform predominantly expressed in nerve terminals. Nemoto Y, etal., J Biol Chem 2001 Nov 2;276(44):41133-42.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. The NECAP PHear domain increases clathrin accessory protein binding potential. Ritter B, etal., EMBO J. 2007 Sep 19;26(18):4066-77. Epub 2007 Aug 30.
17. NECAP 1 regulates AP-2 interactions to control vesicle size, number, and cargo during clathrin-mediated endocytosis. Ritter B, etal., PLoS Biol. 2013 Oct;11(10):e1001670. doi: 10.1371/journal.pbio.1001670. Epub 2013 Oct 1.
18. The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module. Rosenthal JA, etal., J Biol Chem 1999 Nov 26;274(48):33959-65.
19. TTP specifically regulates the internalization of the transferrin receptor. Tosoni D, etal., Cell. 2005 Dec 2;123(5):875-88.
20. Crystal structure of the alpha appendage of AP-2 reveals a recruitment platform for clathrin-coat assembly. Traub LM, etal., Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8907-12.
21. Amphiphysin heterodimers: potential role in clathrin-mediated endocytosis. Wigge P, etal., Mol Biol Cell 1997 Oct;8(10):2003-15.
22. Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Wilhelm BG, etal., Science. 2014 May 30;344(6187):1023-8. doi: 10.1126/science.1252884.
23. A single PXXP motif in the C-terminal region of srGAP3 mediates binding to multiple SH3 domains. Wuertenberger S and Groemping Y, FEBS Lett. 2015 Apr 28;589(10):1156-63. doi: 10.1016/j.febslet.2015.03.014. Epub 2015 Mar 24.
24. Expression of the endocytic proteins dynamin and amphiphysin in rat gastric enterochromaffin-like cells. Zanner R, etal., J Cell Sci. 2004 May 1;117(Pt 11):2369-76.
Additional References at PubMed
PMID:8552632   PMID:9195986   PMID:9259551   PMID:9694653   PMID:11382783   PMID:15090044   PMID:15207364   PMID:15262992   PMID:15821731   PMID:15953416   PMID:16903783   PMID:17855509  
PMID:18344231   PMID:19144635   PMID:19759398   PMID:21700703   PMID:22750946   PMID:22871113   PMID:23785143   PMID:28235806   PMID:29476059  


Genomics

Comparative Map Data
Amph
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81750,435,018 - 50,678,583 (-)NCBIGRCr8
mRatBN7.21745,739,385 - 45,982,905 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1745,739,395 - 45,983,315 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1748,180,900 - 48,690,815 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01752,949,166 - 53,178,746 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01747,057,349 - 47,292,588 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01748,304,324 - 48,562,838 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1748,304,322 - 48,562,905 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01746,357,604 - 46,621,763 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41753,558,804 - 53,802,936NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11753,561,655 - 53,805,777NCBI
Cytogenetic Map17q11NCBI
AMPH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38738,383,704 - 38,631,373 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl738,383,704 - 38,631,420 (-)EnsemblGRCh38hg38GRCh38
GRCh37738,423,305 - 38,670,973 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36738,389,830 - 38,637,545 (-)NCBINCBI36Build 36hg18NCBI36
Build 34738,196,545 - 38,444,260NCBI
Celera738,411,134 - 38,658,846 (-)NCBICelera
Cytogenetic Map7p14.1NCBI
HuRef738,307,292 - 38,555,371 (-)NCBIHuRef
CHM1_1738,425,940 - 38,673,786 (-)NCBICHM1_1
T2T-CHM13v2.0738,540,588 - 38,788,026 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2738,460,969 - 38,708,834 (-)NCBI
Amph
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391319,132,524 - 19,335,089 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1319,132,375 - 19,335,091 (+)EnsemblGRCm39 Ensembl
GRCm381318,948,142 - 19,154,032 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1318,948,205 - 19,150,921 (+)EnsemblGRCm38mm10GRCm38
MGSCv371319,040,240 - 19,242,784 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361318,955,836 - 19,158,380 (+)NCBIMGSCv36mm8
Celera1319,259,525 - 19,457,406 (+)NCBICelera
Cytogenetic Map13A2NCBI
cM Map136.89NCBI
Amph
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554604,804,442 - 5,023,202 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554604,804,400 - 5,024,312 (+)NCBIChiLan1.0ChiLan1.0
LOC100995139
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2643,214,846 - 43,461,235 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1791,539,581 - 91,785,970 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0739,015,699 - 39,262,120 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1739,250,081 - 39,495,844 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl739,250,081 - 39,495,844 (-)Ensemblpanpan1.1panPan2
AMPH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11811,132,078 - 11,261,847 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1811,143,446 - 11,260,841 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1810,903,625 - 11,114,792 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01811,099,548 - 11,310,938 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1811,098,056 - 11,309,936 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11811,076,355 - 11,287,485 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01811,044,639 - 11,263,972 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01811,160,063 - 11,371,410 (+)NCBIUU_Cfam_GSD_1.0
Amph
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511894,747,942 - 94,972,174 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647813,960,771 - 14,183,764 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647813,959,669 - 14,183,835 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AMPH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9108,799,793 - 108,971,660 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19108,800,718 - 108,971,575 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29119,651,630 - 119,751,221 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Amph
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474022,399,244 - 22,614,608 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474022,399,302 - 22,615,736 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Amph
3726 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:81
Count of miRNA genes:78
Interacting mature miRNAs:81
Transcripts:ENSRNOT00000017102
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171533061355836425Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
7394837Memor18Memory QTL 18exploratory behavior trait (VT:0010471)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)171864018263640182Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172245492450909196Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172308056759555013Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318457246843Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172702794956836890Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172702794960463643Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)172738994653481766Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173136839162109574Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173136839173951021Rat
2313854Bp343Blood pressure QTL 3433.9life span trait (VT:0005372)age at time of death (CMO:0001193)173199078450909196Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)173455084373951021Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173583708569599340Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
2317054Aia12Adjuvant induced arthritis QTL 124.24joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)173828150983281509Rat
2317060Aia26Adjuvant induced arthritis QTL 263.22joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)173828150983281509Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174054004180387013Rat
1358295Aocep1Aortic cell protein QTL 16.10.00000071thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
631497Bp98Blood pressure QTL 983.66arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)174135465160463643Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)174207316069599340Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)174207316069599340Rat

Markers in Region
RH131007  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2863,318,169 - 63,318,360 (+)MAPPERmRatBN7.2
mRatBN7.21745,886,101 - 45,886,303 (+)MAPPERmRatBN7.2
Rnor_6.01748,455,564 - 48,455,765NCBIRnor6.0
Rnor_6.0867,747,980 - 67,748,170NCBIRnor6.0
Rnor_5.01746,508,844 - 46,509,045UniSTSRnor5.0
Rnor_5.0867,476,727 - 67,476,917UniSTSRnor5.0
RGSC_v3.4867,001,823 - 67,002,013UniSTSRGSC3.4
RGSC_v3.41753,705,754 - 53,705,955UniSTSRGSC3.4
Celera1741,984,143 - 41,984,344UniSTS
Celera862,733,083 - 62,733,273UniSTS
Cytogenetic Map17q11UniSTS
Cytogenetic Map8q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 15
Low 2 8 6 57 26 25 11
Below cutoff 41 13 7 10 7 8 9 2 9 16 8

Sequence


RefSeq Acc Id: ENSRNOT00000017102   ⟹   ENSRNOP00000017102
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1745,739,395 - 45,983,315 (-)Ensembl
Rnor_6.0 Ensembl1748,304,322 - 48,562,838 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000080800   ⟹   ENSRNOP00000073615
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1745,739,395 - 45,982,989 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000084702   ⟹   ENSRNOP00000070116
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1745,739,395 - 45,983,315 (-)Ensembl
Rnor_6.0 Ensembl1748,304,329 - 48,562,905 (-)Ensembl
RefSeq Acc Id: NM_022217   ⟹   NP_071553
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81750,435,018 - 50,678,501 (-)NCBI
mRatBN7.21745,739,385 - 45,982,883 (-)NCBI
Rnor_6.01748,304,324 - 48,562,838 (-)NCBI
Rnor_5.01746,357,604 - 46,621,763 (-)NCBI
RGSC_v3.41753,558,804 - 53,802,936 (-)RGD
Sequence:
RefSeq Acc Id: XM_039096040   ⟹   XP_038951968
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81750,435,018 - 50,581,884 (-)NCBI
mRatBN7.21745,739,385 - 45,886,191 (-)NCBI
RefSeq Acc Id: XM_039096041   ⟹   XP_038951969
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81750,435,018 - 50,678,583 (-)NCBI
mRatBN7.21745,739,385 - 45,982,905 (-)NCBI
RefSeq Acc Id: XM_039096042   ⟹   XP_038951970
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81750,435,018 - 50,678,494 (-)NCBI
mRatBN7.21745,739,385 - 45,982,867 (-)NCBI
RefSeq Acc Id: XM_063276719   ⟹   XP_063132789
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81750,435,018 - 50,678,571 (-)NCBI
RefSeq Acc Id: NP_071553   ⟸   NM_022217
- UniProtKB: O08838 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070116   ⟸   ENSRNOT00000084702
RefSeq Acc Id: ENSRNOP00000017102   ⟸   ENSRNOT00000017102
RefSeq Acc Id: XP_038951969   ⟸   XM_039096041
- Peptide Label: isoform X2
- UniProtKB: O08838 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038951970   ⟸   XM_039096042
- Peptide Label: isoform X3
- UniProtKB: O08838 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038951968   ⟸   XM_039096040
- Peptide Label: isoform X1
- UniProtKB: O08838 (UniProtKB/Swiss-Prot),   A0A0G2K5Z4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000073615   ⟸   ENSRNOT00000080800
RefSeq Acc Id: XP_063132789   ⟸   XM_063276719
- Peptide Label: isoform X4
Protein Domains
BAR   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K5Z4-F1-model_v2 AlphaFold A0A0G2K5Z4 1-614 view protein structure
AF-O08838-F1-model_v2 AlphaFold O08838 1-683 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700504
Promoter ID:EPDNEW_R11028
Type:initiation region
Name:Amph_1
Description:amphiphysin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01748,562,914 - 48,562,974EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620274 AgrOrtholog
BIND 130419
  130420
  130421
  134465
  144371
BioCyc Gene G2FUF-9132 BioCyc
Ensembl Genes ENSRNOG00000012490 Ensembl
  ENSRNOG00000059510 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017102 ENTREZGENE
  ENSRNOT00000017102.7 UniProtKB/TrEMBL
  ENSRNOT00000080800.2 UniProtKB/TrEMBL
  ENSRNOT00000084702.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 Domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AH/BAR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Amphiphysin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Amphiphysin_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Amphiphysin_I_SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BAR_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:60668 UniProtKB/Swiss-Prot
NCBI Gene 60668 ENTREZGENE
PANTHER AMPHIPHYSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR46514:SF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Amph PhenoGen
PRINTS AMPHIPHYSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AMPHIPHYSIN1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3DOMAIN UniProtKB/Swiss-Prot
PROSITE BAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012490 RatGTEx
  ENSRNOG00000059510 RatGTEx
SMART BAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF103657 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JX32_RAT UniProtKB/TrEMBL
  A0A0G2K5Z4 ENTREZGENE, UniProtKB/TrEMBL
  AMPH_RAT UniProtKB/Swiss-Prot
  F1LPP0_RAT UniProtKB/TrEMBL
  O08838 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Amph  amphiphysin  LOC100909679  amphiphysin-like  Data merged from RGD:6502395 737654 PROVISIONAL
2013-04-17 Amph  amphiphysin  LOC687233  similar to amphiphysin 1  Data merged from RGD:1587745 737654 PROVISIONAL
2012-07-05 LOC100909679  amphiphysin-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-02-22 Amph  amphiphysin  Amph1  amphiphysin 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC687233  similar to amphiphysin 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-20 Amph1  amphiphysin 1    amphiphysin  Symbol updated 1299863 APPROVED
2002-08-07 Amph1  amphiphysin      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a src homology 3 domain 631926
gene_physical_interaction forms a heterodimer with Amph2 that activates dynamin GTPase activity 631926