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Gene: DNM2 (dynamin 2) Homo sapiens
Symbol: DNM2
Name: dynamin 2
Description: Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined. [provided by RefSeq, Jun 2010]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CMT2M; CMTDI1; CMTDIB; DI-CMTB; DYN2; dynamin II; dynamin-2; DYNII; LCCS5
Mus musculus (house mouse) : Dnm2 (dynamin 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dnm2 (dynamin 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dnm2 (dynamin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : DNM2 (dynamin 2)
Canis lupus familiaris (dog) : DNM2 (dynamin 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dnm2 (dynamin 2)
Sus scrofa (pig) : DNM2 (dynamin 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381910,718,053 - 10,831,910 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371910,828,729 - 10,944,169 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,689,755 - 10,803,579 (+)NCBINCBI36hg18NCBI36
Build 341910,689,754 - 10,803,579NCBI
Celera1910,723,575 - 10,837,431 (+)NCBI
Cytogenetic Map19p13.2NCBI
HuRef1910,405,937 - 10,520,718 (+)NCBIHuRef
CHM1_11910,829,940 - 10,943,823 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on DNM2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 730970
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2019-10-01
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.