RGD Reference Report - SRC-mediated phosphorylation of dynamin and cortactin regulates the "constitutive" endocytosis of transferrin. - Rat Genome Database

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SRC-mediated phosphorylation of dynamin and cortactin regulates the "constitutive" endocytosis of transferrin.

Authors: Cao, H  Chen, J  Krueger, EW  McNiven, MA 
Citation: Cao H, etal., Mol Cell Biol. 2010 Feb;30(3):781-92. doi: 10.1128/MCB.00330-09. Epub 2009 Dec 7.
RGD ID: 10047197
Pubmed: PMID:19995918   (View Abstract at PubMed)
PMCID: PMC2812239   (View Article at PubMed Central)
DOI: DOI:10.1128/MCB.00330-09   (Journal Full-text)

The mechanisms by which epithelial cells regulate clathrin-mediated endocytosis (CME) of transferrin are poorly defined and generally viewed as a constitutive process that occurs continuously without regulatory constraints. In this study, we demonstrate for the first time that endocytosis of the transferrin receptor is a regulated process that requires activated Src kinase and, subsequently, phosphorylation of two important components of the endocytic machinery, namely, the large GTPase dynamin 2 (Dyn2) and its associated actin-binding protein, cortactin (Cort). To our knowledge these findings are among the first to implicate an Src-mediated endocytic cascade in what was previously presumed to be a nonregulated internalization process.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CttnRatreceptor-mediated endocytosis involved_inIMP PMID:19995918UniProt 
Dnm2Ratreceptor-mediated endocytosis involved_inIMP PMID:19995918UniProt 

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CttnRatclathrin-coated pit located_inIDA PMID:19995918UniProt 
Dnm2Ratclathrin-coated pit located_inIDA PMID:19995918UniProt 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CttnRatprotein binding enablesIPIUniProtKB:P39052PMID:19995918UniProt 
Dnm2Ratprotein binding enablesIPIUniProtKB:Q66HL2PMID:19995918UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Cttn  (cortactin)
Dnm2  (dynamin 2)


Additional Information