Dnm2 (dynamin 2) - Rat Genome Database

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Gene: Dnm2 (dynamin 2) Heterocephalus glaber
Analyze
Symbol: Dnm2
Name: dynamin 2
RGD ID: 18931557
Description: ENCODES a protein that exhibits D2 dopamine receptor binding (ortholog); GTPase activity (ortholog); nitric-oxide synthase binding (ortholog); INVOLVED IN actin filament bundle organization (ortholog); aorta development (ortholog); autophagy (ortholog); PARTICIPATES IN platelet-derived growth factor signaling pathway; syndecan signaling pathway; vascular endothelial growth factor signaling pathway; ASSOCIATED WITH alpha-mannosidosis (ortholog); autosomal dominant centronuclear myopathy (ortholog); centronuclear myopathy (ortholog); FOUND IN cell cortex (ortholog); cell junction (ortholog); centriole (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: dynamin-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248282,727,112 - 2,807,319 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248282,727,136 - 2,805,248 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin filament bundle organization  (ISO)
aorta development  (ISO)
autophagy  (ISO)
cellular response to carbon monoxide  (ISO)
cellular response to dopamine  (ISO)
cellular response to nitric oxide  (ISO)
cellular response to X-ray  (ISO)
centrosome cycle  (ISO)
coronary vasculature development  (ISO)
endocytosis  (IEA)
G protein-coupled receptor internalization  (ISO)
Golgi to plasma membrane transport  (ISO)
macropinocytosis  (ISO)
membrane tubulation  (ISO)
negative regulation of membrane tubulation  (ISO)
negative regulation of non-motile cilium assembly  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
neuron projection morphogenesis  (ISO)
positive regulation of clathrin-dependent endocytosis  (ISO)
positive regulation of endocytosis  (ISO)
positive regulation of lamellipodium assembly  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of P-type sodium:potassium-exchanging transporter activity  (ISO)
positive regulation of phagocytosis  (ISO)
positive regulation of substrate adhesion-dependent cell spreading  (ISO)
postsynaptic endocytosis  (ISO)
protein polymerization  (ISO)
receptor internalization  (IEA)
receptor-mediated endocytosis  (ISO)
regulation of axon extension  (ISO)
regulation of Golgi organization  (ISO)
regulation of Rac protein signal transduction  (ISO)
response to cocaine  (ISO)
response to light stimulus  (ISO)
spermatogenesis  (ISO)
stress fiber assembly  (ISO)
synaptic vesicle budding from presynaptic endocytic zone membrane  (IEA)
synaptic vesicle endocytosis  (ISO)
transferrin transport  (ISO)
ventricular septum development  (ISO)
vesicle scission  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Dnm2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248282,727,112 - 2,807,319 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248282,727,136 - 2,805,248 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
DNM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381910,718,079 - 10,831,903 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1910,718,055 - 10,833,488 (+)EnsemblGRCh38hg38GRCh38
GRCh371910,828,755 - 10,942,579 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,689,755 - 10,803,579 (+)NCBINCBI36Build 36hg18NCBI36
Build 341910,689,754 - 10,803,579NCBI
Celera1910,723,575 - 10,837,431 (+)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef1910,405,937 - 10,520,718 (+)NCBIHuRef
CHM1_11910,829,940 - 10,943,823 (+)NCBICHM1_1
T2T-CHM13v2.01910,844,675 - 10,958,914 (+)NCBIT2T-CHM13v2.0
Dnm2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39921,336,167 - 21,419,055 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl921,336,204 - 21,419,055 (+)EnsemblGRCm39 Ensembl
GRCm38921,424,908 - 21,507,759 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl921,424,908 - 21,507,759 (+)EnsemblGRCm38mm10GRCm38
MGSCv37921,229,389 - 21,311,568 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36921,175,347 - 21,257,526 (+)NCBIMGSCv36mm8
Celera918,693,560 - 18,775,727 (+)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.79NCBI
Dnm2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8828,254,344 - 28,336,297 (+)NCBIGRCr8
mRatBN7.2819,978,313 - 20,060,162 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,978,400 - 20,060,157 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx824,010,157 - 24,091,388 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0822,307,994 - 22,389,225 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0820,208,114 - 20,289,207 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0822,458,869 - 22,540,649 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,458,899 - 22,540,524 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0822,512,875 - 22,594,760 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4820,527,130 - 20,610,749 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1820,527,130 - 20,610,749 (+)NCBI
Celera821,369,673 - 21,450,772 (+)NCBICelera
Cytogenetic Map8q13NCBI
Dnm2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554951,860,644 - 1,934,818 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554951,860,644 - 1,934,589 (+)NCBIChiLan1.0ChiLan1.0
DNM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22015,638,738 - 15,752,084 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11914,637,331 - 14,750,677 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01910,272,172 - 10,386,032 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11910,974,699 - 11,107,354 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1910,933,672 - 11,106,478 (+)Ensemblpanpan1.1panPan2
DNM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12050,398,866 - 50,487,303 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2050,398,864 - 50,487,241 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2050,271,460 - 50,359,936 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02050,920,493 - 51,009,858 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2050,919,081 - 51,019,741 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12050,129,310 - 50,218,400 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02050,556,853 - 50,645,731 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02050,798,300 - 50,886,770 (-)NCBIUU_Cfam_GSD_1.0
Dnm2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118209,308,313 - 209,397,278 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936659957,392 - 1,049,188 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936659957,408 - 1,046,393 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl269,474,031 - 69,574,424 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1269,474,011 - 69,574,427 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2269,941,439 - 70,005,977 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DNM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.169,718,014 - 9,830,061 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl69,718,244 - 9,831,206 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607410,123,763 - 10,234,870 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000020193   ⟹   ENSHGLP00000019993
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248282,727,112 - 2,807,319 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000020194   ⟹   ENSHGLP00000019994
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248282,727,112 - 2,807,319 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000020195   ⟹   ENSHGLP00000019995
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248282,727,112 - 2,804,576 (+)Ensembl
RefSeq Acc Id: XM_004865532   ⟹   XP_004865589
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248282,727,136 - 2,804,574 (+)NCBI
RefSeq Acc Id: XM_004865533   ⟹   XP_004865590
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248282,727,136 - 2,804,574 (+)NCBI
RefSeq Acc Id: XM_004865534   ⟹   XP_004865591
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248282,727,136 - 2,804,574 (+)NCBI
RefSeq Acc Id: XM_004865535   ⟹   XP_004865592
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248282,727,136 - 2,804,574 (+)NCBI
RefSeq Acc Id: XM_004865536   ⟹   XP_004865593
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248282,727,136 - 2,804,574 (+)NCBI
RefSeq Acc Id: XM_004865537   ⟹   XP_004865594
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248282,727,136 - 2,804,574 (+)NCBI
RefSeq Acc Id: XM_004865538   ⟹   XP_004865595
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248282,727,136 - 2,805,248 (+)NCBI
RefSeq Acc Id: XM_021245113   ⟹   XP_021100772
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248282,727,136 - 2,800,269 (+)NCBI
RefSeq Acc Id: XP_004865595   ⟸   XM_004865538
- Peptide Label: isoform X7
- UniProtKB: A0AAX6Q1Q7 (UniProtKB/TrEMBL),   G5BUH8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004865589   ⟸   XM_004865532
- Peptide Label: isoform X1
- UniProtKB: A0AAX6Q217 (UniProtKB/TrEMBL),   G5BUH8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004865591   ⟸   XM_004865534
- Peptide Label: isoform X3
- UniProtKB: A0AAX6Q518 (UniProtKB/TrEMBL),   G5BUH8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004865593   ⟸   XM_004865536
- Peptide Label: isoform X5
- UniProtKB: A0AAX6Q5H0 (UniProtKB/TrEMBL),   G5BUH8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004865590   ⟸   XM_004865533
- Peptide Label: isoform X2
- UniProtKB: A0AAX6Q534 (UniProtKB/TrEMBL),   G5BUH8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004865592   ⟸   XM_004865535
- Peptide Label: isoform X4
- UniProtKB: A0AAX6Q5Z5 (UniProtKB/TrEMBL),   G5BUH8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004865594   ⟸   XM_004865537
- Peptide Label: isoform X6
- UniProtKB: A0AAX6Q1Y5 (UniProtKB/TrEMBL),   G5BUH8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021100772   ⟸   XM_021245113
- Peptide Label: isoform X8
- UniProtKB: A0AAX6RVU6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000019995   ⟸   ENSHGLT00000020195
Ensembl Acc Id: ENSHGLP00000019993   ⟸   ENSHGLT00000020193
Ensembl Acc Id: ENSHGLP00000019994   ⟸   ENSHGLT00000020194


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000014318 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000020193 ENTREZGENE
  ENSHGLT00000020194 ENTREZGENE
  ENSHGLT00000020195 ENTREZGENE
Gene3D-CATH Dynamin, middle domain UniProtKB/TrEMBL
  P-loop containing nucleotide triphosphate hydrolases UniProtKB/TrEMBL
  Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) UniProtKB/TrEMBL
InterPro Dynamin UniProtKB/TrEMBL
  Dynamin_GTPase UniProtKB/TrEMBL
  Dynamin_GTPase_CS UniProtKB/TrEMBL
  Dynamin_N UniProtKB/TrEMBL
  Dynamin_stalk UniProtKB/TrEMBL
  G_DYNAMIN_dom UniProtKB/TrEMBL
  GED UniProtKB/TrEMBL
  GED_dom UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
NCBI Gene Dnm2 ENTREZGENE
PANTHER DYNAMIN UniProtKB/TrEMBL
  DYNAMIN-2 UniProtKB/TrEMBL
Pfam Dynamin_M UniProtKB/TrEMBL
  Dynamin_N UniProtKB/TrEMBL
  GED UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
PRINTS DYNAMIN UniProtKB/TrEMBL
PROSITE G_DYNAMIN_1 UniProtKB/TrEMBL
  G_DYNAMIN_2 UniProtKB/TrEMBL
  GED UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
SMART DYNc UniProtKB/TrEMBL
  GED UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP P-loop containing nucleoside triphosphate hydrolases UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
UniProt A0AAX6Q1Q7 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6Q1Y5 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6Q217 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6Q518 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6Q534 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6Q5H0 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6Q5Z5 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6RVU6 ENTREZGENE, UniProtKB/TrEMBL
  G5BUH8 ENTREZGENE, UniProtKB/TrEMBL