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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620795
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Src
Name: SRC proto-oncogene, non-receptor tyrosine kinase
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Srcincreases activityEXP 6480464CTDTetrachlorodibenzodioxin results in increased activity of SRC proteinPMID:15592923
Srcincreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of SRC mRNAPMID:33387578
Srcincreases localizationEXP 6480464CTDTetrachlorodibenzodioxin results in increased localization of SRC proteinPMID:10401681
Srcmultiple interactionsEXP 6480464CTDgeldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of SRC protein]; SRC protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]PMID:10401681 PMID:11133817
Srcaffects expressionISOSrc (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of SRC mRNAPMID:26377647
Srcaffects localizationISOSRC (Homo sapiens)6480464CTDTetrachlorodibenzodioxin affects the localization of SRC proteinPMID:17223712
Srcincreases activityISOSrc (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased activity of SRC proteinPMID:8937476 PMID:9380030
Srcincreases expressionISOSRC (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of SRC mRNAPMID:20106945 PMID:21632981
Srcincreases expressionISOSrc (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of SRC mRNA; Tetrachlorodibenzodioxin results in increased expression of SRC proteinPMID:14708085 PMID:16906519 PMID:18606429 PMID:22430074 PMID:28213091 PMID:3380784
Srcincreases phosphorylationISOSRC (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased phosphorylation of SRC proteinPMID:21145940
Srcincreases phosphorylationISOSrc (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased phosphorylation of SRC proteinPMID:19782052 PMID:23639249
Srcincreases response to substanceISOSrc (Mus musculus)6480464CTDSRC protein results in increased susceptibility to TetrachlorodibenzodioxinPMID:11882352
Srcmultiple interactionsISOSRC (Homo sapiens)6480464CTD3'-methoxy-4'-nitroflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of SRC protein]; AG 1879 inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of SRC protein]; geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of SRC protein]; SRC protein promotes the reaction [[Dihydrotestosterone co-treated with Tetrachlorodibenzodioxin] results in increased activity of AR protein]; Tetrachlorodibenzodioxin inhibits the reaction [SRC protein results in increased expression of G6PC1 mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [SRC protein results in increased expression of SLC2A2 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [CDC37 protein binds to SRC protein]PMID:17223712 PMID:19815066 PMID:21145940 PMID:31520823
Srcmultiple interactionsISOSrc (Mus musculus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of SRC protein]; 3'-methoxy-4'-nitroflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of SRC protein]; [AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of SRC protein]; [AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of STAT3 protein]; [AG 1879 results in decreased activity of SRC protein] which results in decreased susceptibility to Tetrachlorodibenzodioxin; AG 1879 inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of SRC protein]; Calcium deficiency inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of SRC protein]; Methylcholanthrene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [SRC protein binds to AHR protein]]; PTGES protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of SRC mRNA]; SRC protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of TGFB1 mRNA]; SRC protein promotes the reaction [Tetrachlorodibenzodioxin affects the expression of TFAP2C mRNA]; SRC protein promotes the reaction [Tetrachlorodibenzodioxin affects the expression of TRP53 mRNA]; SRC protein promotes the reaction [Tetrachlorodibenzodioxin inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of PPARG mRNA]]; SRC protein promotes the reaction [Tetrachlorodibenzodioxin inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of SCD1 mRNA]]; SRC protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased abundance of Glycogen]; SRC protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of CEBPA mRNA]; SRC protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of CEBPB mRNA]; SRC protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of NMT1 mRNA]; SRC protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of PCK1 mRNA]; SRC protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased uptake of Glucose]; SRC protein promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CEBPB protein]; SRC protein promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CEBPD protein]; SRC protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CEBPB mRNA]; SRC protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CEBPD mRNA]; SRC protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of PDGFA mRNA]; SRC protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of PDGFRA mRNA]; SRC protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of STAT3 mRNA]; SRC protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of TGFA mRNA]; Tetrachlorodibenzodioxin results in increased activity of [SRC protein binds to AHR protein]; TGFA gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SRC mRNA]PMID:11882352 PMID:11990355 PMID:14505802 PMID:14708085 PMID:16906519 PMID:19782052 PMID:22430074 PMID:23639249 PMID:8937476
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