RGD Reference Report - The Met tyrosine kinase receptor in development and cancer. - Rat Genome Database

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The Met tyrosine kinase receptor in development and cancer.

Authors: Gentile, A  Trusolino, L  Comoglio, PM 
Citation: Gentile A, etal., Cancer Metastasis Rev. 2008 Mar;27(1):85-94.
RGD ID: 2299174
Pubmed: PMID:18175071   (View Abstract at PubMed)
DOI: DOI:10.1007/s10555-007-9107-6   (Journal Full-text)

Met is a tyrosine kinase receptor, encoded by an oncogene, whose crucial role has been elucidated during the last two decades. The complex biological program triggered by Met has been dissected and its biological relevance in both physiology and pathology has been proven. Met supports a morphogenetic program, known as invasive growth, taking place both during embryogenesis and adulthood. In tumors Met is often aberrantly activated, giving rise to the pathological counterpart of the invasive growth program: cancer progression towards metastasis. Several approaches have been recently developed to interfere with the tumorigenic and metastatic processes triggered by Met.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CBLHumanscatter factor/hepatocyte growth factor signaling pathway   TAS  RGD 
CblMousescatter factor/hepatocyte growth factor signaling pathway   ISOCBL (Homo sapiens) RGD 
CblRatscatter factor/hepatocyte growth factor signaling pathway   ISOCBL (Homo sapiens) RGD 
GAB1Humanscatter factor/hepatocyte growth factor signaling pathway   TAS  RGD 
GRB2Humanscatter factor/hepatocyte growth factor signaling pathway   TAS  RGD 
Gab1Ratscatter factor/hepatocyte growth factor signaling pathway   ISOGAB1 (Homo sapiens) RGD 
Gab1Mousescatter factor/hepatocyte growth factor signaling pathway   ISOGAB1 (Homo sapiens) RGD 
Grb2Ratscatter factor/hepatocyte growth factor signaling pathway   ISOGRB2 (Homo sapiens) RGD 
Grb2Mousescatter factor/hepatocyte growth factor signaling pathway   ISOGRB2 (Homo sapiens) RGD 
HGFHumanscatter factor/hepatocyte growth factor signaling pathway   TAS  RGD 
HgfRatscatter factor/hepatocyte growth factor signaling pathway   ISOHGF (Homo sapiens) RGD 
HgfMousescatter factor/hepatocyte growth factor signaling pathway   ISOHGF (Homo sapiens) RGD 
METHumanscatter factor/hepatocyte growth factor signaling pathway   TAS  RGD 
MetRatscatter factor/hepatocyte growth factor signaling pathway   ISOMET (Homo sapiens) RGD 
MetMousescatter factor/hepatocyte growth factor signaling pathway   ISOMET (Homo sapiens) RGD 
PIK3R1Humanscatter factor/hepatocyte growth factor signaling pathway   TAS  RGD 
PLCG1Humanscatter factor/hepatocyte growth factor signaling pathway   TAS  RGD 
PTPN11Humanscatter factor/hepatocyte growth factor signaling pathway   TAS  RGD 
Pik3r1Ratscatter factor/hepatocyte growth factor signaling pathway   ISOPIK3R1 (Homo sapiens) RGD 
Pik3r1Mousescatter factor/hepatocyte growth factor signaling pathway   ISOPIK3R1 (Homo sapiens) RGD 
Plcg1Ratscatter factor/hepatocyte growth factor signaling pathway   ISOPLCG1 (Homo sapiens) RGD 
Plcg1Mousescatter factor/hepatocyte growth factor signaling pathway   ISOPLCG1 (Homo sapiens) RGD 
Ptpn11Ratscatter factor/hepatocyte growth factor signaling pathway   ISOPTPN11 (Homo sapiens) RGD 
Ptpn11Mousescatter factor/hepatocyte growth factor signaling pathway   ISOPTPN11 (Homo sapiens) RGD 
SHC1Humanscatter factor/hepatocyte growth factor signaling pathway   TAS  RGD 
SRCHumanscatter factor/hepatocyte growth factor signaling pathway   TAS  RGD 
Shc1Ratscatter factor/hepatocyte growth factor signaling pathway   ISOSHC1 (Homo sapiens) RGD 
Shc1Mousescatter factor/hepatocyte growth factor signaling pathway   ISOSHC1 (Homo sapiens) RGD 
SrcRatscatter factor/hepatocyte growth factor signaling pathway   ISOSRC (Homo sapiens) RGD 
SrcMousescatter factor/hepatocyte growth factor signaling pathway   ISOSRC (Homo sapiens) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Cbl  (Cbl proto-oncogene)
Gab1  (GRB2-associated binding protein 1)
Grb2  (growth factor receptor bound protein 2)
Hgf  (hepatocyte growth factor)
Met  (MET proto-oncogene, receptor tyrosine kinase)
Pik3r1  (phosphoinositide-3-kinase regulatory subunit 1)
Plcg1  (phospholipase C, gamma 1)
Ptpn11  (protein tyrosine phosphatase, non-receptor type 11)
Shc1  (SHC adaptor protein 1)
Src  (SRC proto-oncogene, non-receptor tyrosine kinase)

Genes (Mus musculus)
Cbl  (Casitas B-lineage lymphoma)
Gab1  (growth factor receptor bound protein 2-associated protein 1)
Grb2  (growth factor receptor bound protein 2)
Hgf  (hepatocyte growth factor)
Met  (met proto-oncogene)
Pik3r1  (phosphoinositide-3-kinase regulatory subunit 1)
Plcg1  (phospholipase C, gamma 1)
Ptpn11  (protein tyrosine phosphatase, non-receptor type 11)
Shc1  (src homology 2 domain-containing transforming protein C1)
Src  (Rous sarcoma oncogene)

Genes (Homo sapiens)
CBL  (Cbl proto-oncogene)
GAB1  (GRB2 associated binding protein 1)
GRB2  (growth factor receptor bound protein 2)
HGF  (hepatocyte growth factor)
MET  (MET proto-oncogene, receptor tyrosine kinase)
PIK3R1  (phosphoinositide-3-kinase regulatory subunit 1)
PLCG1  (phospholipase C gamma 1)
PTPN11  (protein tyrosine phosphatase non-receptor type 11)
SHC1  (SHC adaptor protein 1)
SRC  (SRC proto-oncogene, non-receptor tyrosine kinase)


Additional Information