Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: HGF (hepatocyte growth factor) Homo sapiens
Symbol: HGF
Name: hepatocyte growth factor
Description: Exhibits chemoattractant activity and identical protein binding activity. Involved in several processes, including cellular response to hepatocyte growth factor stimulus; negative regulation of programmed cell death; and positive regulation of macromolecule metabolic process. Localizes to membrane. Implicated in several diseases, including artery disease (multiple); autosomal recessive nonsyndromic deafness 39; eye disease (multiple); neuropathy (multiple); and rheumatic disease (multiple). Biomarker of several diseases, including artery disease (multiple); biliary tract disease (multiple); myositis (multiple); retinal disease (multiple); and rheumatoid arthritis (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: deafness, autosomal recessive 39; DFNB39; F-TCF; fibroblast-derived tumor cytotoxic factor; hepatocyte growth factor (hepapoietin A, scatter factor); hepatopoeitin-A; hepatopoietin-A; HGFB; HPTA; lung fibroblast-derived mitogen; SF
Mus musculus (house mouse) : Hgf (hepatocyte growth factor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hgf (hepatocyte growth factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hgf (hepatocyte growth factor)
Pan paniscus (bonobo/pygmy chimpanzee) : HGF (hepatocyte growth factor)
Canis lupus familiaris (dog) : HGF (hepatocyte growth factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hgf (hepatocyte growth factor)
Sus scrofa (pig) : HGF (hepatocyte growth factor)
Chlorocebus sabaeus (African green monkey) : HGF (hepatocyte growth factor)
Heterocephalus glaber (naked mole-rat) : Hgf (hepatocyte growth factor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl781,699,010 - 81,770,438 (-)EnsemblGRCh38hg38GRCh38
GRCh38781,699,006 - 81,770,438 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37781,331,444 - 81,399,452 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36781,169,380 - 81,237,388 (-)NCBINCBI36hg18NCBI36
Build 34781,024,867 - 81,044,103NCBI
Celera776,032,788 - 76,100,524 (-)NCBI
Cytogenetic Map7q21.11NCBI
HuRef775,935,402 - 76,003,191 (-)NCBIHuRef
CHM1_1781,258,674 - 81,329,573 (-)NCBICHM1_1
CRA_TCAGchr7v2780,663,506 - 80,731,238 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on HGF
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 70837
Created: 2002-06-25
Species: Homo sapiens
Last Modified: 2020-05-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.