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Gene: CBL (Cbl proto-oncogene) Homo sapiens
Symbol: CBL
Name: Cbl proto-oncogene
Description: Exhibits SH3 domain binding activity and ephrin receptor binding activity. Involved in several processes, including positive regulation of receptor-mediated endocytosis; regulation of signal transduction; and ubiquitin-dependent protein catabolic process. Localizes to several cellular components, including Golgi apparatus; cilium; and cytosol. Predicted to colocalize with flotillin complex. Implicated in acute myeloid leukemia; juvenile myelomonocytic leukemia; lung non-small cell carcinoma; and myeloid neoplasm. Biomarker of congestive heart failure and multiple myeloma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C-CBL; Cas-Br-M (murine) ecotropic retroviral transforming sequence; casitas B-lineage lymphoma proto-oncogene; Cbl proto-oncogene, E3 ubiquitin protein ligase; CBL2; E3 ubiquitin-protein ligase CBL; FRA11B; fragile site, folic acid type, rare, fra(11)(q23.3); NSLL; oncogene CBL2; proto-oncogene c-Cbl; RING finger protein 55; RING-type E3 ubiquitin transferase CBL; RNF55; signal transduction protein CBL
Mus musculus (house mouse) : Cbl (Casitas B-lineage lymphoma)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cbl (Cbl proto-oncogene)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cbl (Cbl proto-oncogene)
Pan paniscus (bonobo/pygmy chimpanzee) : CBL (Cbl proto-oncogene)
Canis lupus familiaris (dog) : CBL (Cbl proto-oncogene)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cbl (Cbl proto-oncogene)
Sus scrofa (pig) : CBL (Cbl proto-oncogene)
Chlorocebus sabaeus (African green monkey) : CBL (Cbl proto-oncogene)
Heterocephalus glaber (naked mole-rat) : Cbl (Cbl proto-oncogene)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl11119,206,298 - 119,313,926 (+)EnsemblGRCh38hg38GRCh38
GRCh38 Ensembl11119,206,276 - 119,313,926 (+)EnsemblGRCh38hg38GRCh38
GRCh3811119,206,339 - 119,308,149 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711119,076,986 - 119,178,859 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611118,582,200 - 118,684,069 (+)NCBINCBI36hg18NCBI36
Build 3411118,582,199 - 118,684,068NCBI
Celera11116,236,024 - 116,339,059 (+)NCBI
Cytogenetic Map11q23.3NCBI
HuRef11115,017,373 - 115,119,562 (+)NCBIHuRef
CHM1_111118,963,252 - 119,065,411 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CBL
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1345184
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.