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Gene: Hgf (hepatocyte growth factor) Mus musculus
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Symbol: Hgf
Name: hepatocyte growth factor
Description: Predicted to have several functions, including protein heterodimerization activity; receptor ligand activity; and serine-type endopeptidase activity. Involved in several processes, including negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling; and regulation of protein phosphorylation. Predicted to localize to the extracellular space. Used to study breast cancer. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune hypersensitivity disease (multiple); autosomal recessive nonsyndromic deafness 39; eye disease (multiple); and neuropathy (multiple). Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Orthologous to human HGF (hepatocyte growth factor).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C230052L06Rik; hepatopoeitin-A; hepatopoietin-A; HGF/SF; NK1; NK2; scatter factor; SF; SF/HGF
Orthologs:
Homo sapiens (human) : HGF (hepatocyte growth factor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Hgf (hepatocyte growth factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hgf (hepatocyte growth factor)
Pan paniscus (bonobo/pygmy chimpanzee) : HGF (hepatocyte growth factor)
Canis lupus familiaris (dog) : HGF (hepatocyte growth factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hgf (hepatocyte growth factor)
Sus scrofa (pig) : HGF (hepatocyte growth factor)
Chlorocebus sabaeus (African green monkey) : HGF (hepatocyte growth factor)
Heterocephalus glaber (naked mole-rat) : Hgf (hepatocyte growth factor)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl516,553,495 - 16,620,152 (+)Ensembl
GRCm38516,553,495 - 16,619,439 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37516,059,368 - 16,125,257 (+)NCBIGRCm37mm9NCBIm37
MGSCv36516,065,374 - 16,131,263 (+)NCBImm8
Celera513,551,947 - 13,617,800 (+)NCBICelera
Cytogenetic Map5 A3NCBI
cM Map57.07NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Hgf
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10708
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-12-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.