Hgf (hepatocyte growth factor) - Rat Genome Database

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Gene: Hgf (hepatocyte growth factor) Mus musculus
Analyze
Symbol: Hgf
Name: hepatocyte growth factor
RGD ID: 10708
MGI Page MGI
Description: Predicted to enable chemoattractant activity; growth factor activity; and identical protein binding activity. Acts upstream of or within several processes, including hepatocyte growth factor receptor signaling pathway; regulation of MAPK cascade; and regulation of cytokine production. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; egg cylinder; embryo mesenchyme; and genitourinary system. Used to study autosomal recessive nonsyndromic deafness 39. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autosomal recessive nonsyndromic deafness 39; eye disease (multiple); neuropathy (multiple); and scleroderma (multiple). Orthologous to human HGF (hepatocyte growth factor).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: C230052L06Rik; hepatopoeitin-A; hepatopoietin-A; HGF/S; HGF/SF; NK; NK1; NK2; scatter factor; SF; SF/HG; SF/HGF
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39516,758,493 - 16,827,448 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl516,758,493 - 16,825,150 (+)EnsemblGRCm39 Ensembl
GRCm38516,553,495 - 16,619,439 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl516,553,495 - 16,620,152 (+)EnsemblGRCm38mm10GRCm38
MGSCv37516,059,368 - 16,125,257 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36516,065,374 - 16,131,263 (+)NCBIMGSCv36mm8
Celera513,552,002 - 13,617,800 (+)NCBICelera
Cytogenetic Map5A3NCBI
cM Map57.07NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Liver Failure  (ISO)
acute myeloid leukemia  (ISO)
adult-onset Still's disease  (ISO)
angle-closure glaucoma  (ISO)
arteriosclerosis  (ISO)
atrial fibrillation  (ISO)
autism spectrum disorder  (ISO)
autosomal recessive nonsyndromic deafness 39  (IAGP,ISO)
Barrett's esophagus  (ISO)
biliary tract benign neoplasm  (ISO)
bilirubin metabolic disorder  (ISO)
brain infarction  (ISO)
cardiomyopathy  (ISO)
carotid artery disease  (ISO)
central nervous system disease  (ISO)
CHARGE syndrome  (ISO)
cholangiocarcinoma  (ISO)
cholesteatoma  (ISO)
Choroidal Neovascularization  (ISO)
Chronic Hepatitis  (ISO)
Copper-Overload Cirrhosis  (ISO)
coronary artery disease  (ISO)
COVID-19  (ISO)
dermatomyositis  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
epilepsy  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Melanoma  (IMP)
Experimental Neoplasms  (ISO)
Facial Nerve Injuries  (ISO)
Gallbladder Neoplasms  (ISO)
genetic disease  (ISO)
graft-versus-host disease  (ISO)
Hearing Loss  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
hypertension  (ISO)
interstitial lung disease  (ISO)
inverted papilloma  (ISO)
keratoconus  (ISO)
Lentigo  (ISO)
limb ischemia  (ISO)
liver cirrhosis  (ISO)
Liver Injury  (ISO)
Liver Neoplasms  (ISO)
localized scleroderma  (ISO)
malignant astrocytoma  (ISO)
malignant mesothelioma  (ISO)
meningioma  (ISO)
Metabolic Syndrome  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
myopia  (ISO)
myositis  (ISO)
Nasal Polyps  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (IEP,ISO)
neovascular inflammatory vitreoretinopathy  (ISO)
Nerve Sheath Neoplasms  (ISO)
neuroblastoma  (ISO)
obesity  (ISO)
Optic Nerve Injuries  (ISO)
Pain  (ISO)
pancreatic cancer  (ISO)
pancreatitis  (ISO)
Parkinson's disease  (ISO)
Penetrating Wounds  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
polymyositis  (ISO)
Polyomavirus Infections  (ISO)
pulmonary fibrosis  (ISO)
Reperfusion Injury  (ISO)
Retina Reperfusion Injury  (ISO)
retinal degeneration  (ISO)
Retinal Neovascularization  (IEP)
retinitis pigmentosa  (ISO)
retinopathy of prematurity  (ISO)
rheumatoid arthritis  (ISO)
Rhinosinusitis  (ISO)
schizophrenia  (ISO)
sciatic neuropathy  (ISO)
Skin Neoplasms  (IDA)
Spinal Cord Injuries  (ISO)
squamous cell carcinoma  (ISO)
Stroke  (ISO)
systemic scleroderma  (ISO)
thrombosis  (ISO)
tongue squamous cell carcinoma  (ISO)
vascular disease  (ISO)
vitiligo  (ISO)
Wounds and Injuries  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-citrinin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(5Z,8Z,11Z,13E)-15-HETE  (ISO)
(S)-nicotine  (EXP,ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 17-glucosiduronic acid  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methylcholanthrene  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (EXP)
4-phenylbutyric acid  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
9-cis-retinoic acid  (ISO)
ABT-737  (ISO)
acetamide  (ISO)
acetic acid  (ISO)
acetylsalicylic acid  (ISO)
actinomycin D  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
aspartame  (EXP)
atazanavir sulfate  (ISO)
benazepril  (ISO)
benzalkonium chloride  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
beraprost  (EXP)
berberine  (EXP,ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP,ISO)
bromosulfophthalein  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (EXP,ISO)
captan  (EXP)
chenodeoxycholic acid  (ISO)
CHIR 99021  (ISO)
choline  (EXP)
ciprofibrate  (ISO)
cisplatin  (ISO)
clothianidin  (ISO)
cordycepin  (ISO)
cortisol  (ISO)
crizotinib  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
DDT  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
Dibromoacetonitrile  (ISO)
Dictamnine  (ISO)
diethyl malate  (EXP)
dioxygen  (EXP,ISO)
diquat  (EXP)
disodium selenite  (EXP,ISO)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
efavirenz  (ISO)
entinostat  (ISO)
ethanol  (EXP)
etodolac  (ISO)
folic acid  (EXP)
genistein  (EXP,ISO)
glutathione  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
heparin  (ISO)
hydrogen peroxide  (ISO)
indometacin  (EXP)
isoniazide  (EXP)
isotretinoin  (ISO)
kaempferol  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (EXP)
lipopolysaccharide  (EXP,ISO)
melphalan  (ISO)
mercury dichloride  (ISO)
methapyrilene  (ISO)
monosodium L-glutamate  (EXP)
myricetin  (ISO)
N-acetyl-L-cysteine  (ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (ISO)
nefazodone  (ISO)
nevirapine  (ISO)
nicotine  (EXP,ISO)
nifedipine  (ISO)
nitrofen  (ISO)
NS-398  (ISO)
NSC 23766  (ISO)
ochratoxin A  (ISO)
orphenadrine  (ISO)
ouabain  (ISO)
oxilofrine  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PD173074  (ISO)
perfluorodecanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (ISO)
PHA-665752  (ISO)
phenobarbital  (EXP,ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
propofol  (ISO)
prostaglandin E2  (ISO)
Ptaquiloside  (EXP)
pyrithione  (EXP)
quercetin  (EXP,ISO)
quercitrin  (ISO)
raloxifene  (ISO)
reactive oxygen species  (EXP,ISO)
reserpine  (ISO)
resveratrol  (EXP,ISO)
riddelliine  (ISO)
rifampicin  (EXP)
rofecoxib  (ISO)
roxarsone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
salubrinal  (ISO)
SB 431542  (ISO)
Securinine  (ISO)
sevoflurane  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sorafenib  (ISO)
sphingosine 1-phosphate  (ISO)
sulfasalazine  (ISO)
sulindac sulfide  (ISO)
Sunset Yellow FCF  (ISO)
tacrine  (ISO)
tamoxifen  (EXP)
taurochenodeoxycholic acid  (ISO)
taurocholic acid  (ISO)
telmisartan  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP,ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triptonide  (EXP)
tunicamycin  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vemurafenib  (ISO)
vorinostat  (ISO)
XAV939  (ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Hepatocyte growth factor is associated with poor prognosis of malignant gliomas and is a predictor for recurrence of meningioma. Arrieta O, etal., Cancer. 2002 Jun 15;94(12):3210-8.
2. Hepatocellular carcinoma and cholangiocarcinoma are associated with high serum levels of hepatocyte growth factor. Balaban YH, etal., Indian J Gastroenterol. 2006 Jul-Aug;25(4):223-4.
3. Met, metastasis, motility and more. Birchmeier C, etal., Nat Rev Mol Cell Biol. 2003 Dec;4(12):915-25.
4. Active scatter factor (HGF/SF) in proliferative vitreoretinal disease. Briggs MC, etal., Invest Ophthalmol Vis Sci. 2000 Sep;41(10):3085-94.
5. c-MET pathway involvement in chronic rhinosinusitis: a genetic association analysis. Castano R, etal., Otolaryngol Head Neck Surg. 2010 May;142(5):665-71.e1-2. doi: 10.1016/j.otohns.2010.01.004.
6. Hepatocyte growth factor/scatter factor promotes retinal angiogenesis through increased urokinase expression. Colombo ES, etal., Invest Ophthalmol Vis Sci. 2007 Apr;48(4):1793-800.
7. Hepatocyte growth factor incorporated into herpes simplex virus vector accelerates facial nerve regeneration after crush injury. Esaki S, etal., Gene Ther. 2011 Nov;18(11):1063-9. doi: 10.1038/gt.2011.57. Epub 2011 May 12.
8. Differential gene expression of MMP-1, TIMP-1 and HGF in clinically involved and uninvolved skin in South Africans with SSc. Frost J, etal., Rheumatology (Oxford). 2012 Jun;51(6):1049-52. doi: 10.1093/rheumatology/ker367. Epub 2012 Jan 27.
9. The Met tyrosine kinase receptor in development and cancer. Gentile A, etal., Cancer Metastasis Rev. 2008 Mar;27(1):85-94.
10. Family-based association analysis of hepatocyte growth factor (HGF) gene polymorphisms in high myopia. Han W, etal., Invest Ophthalmol Vis Sci. 2006 Jun;47(6):2291-9.
11. Identification of novel cellular targets in biliary tract cancers using global gene expression technology. Hansel DE, etal., Am J Pathol. 2003 Jul;163(1):217-29.
12. Levels of vascular endothelial growth factor and hepatocyte growth factor in sera of patients with rheumatic diseases. Hashimoto N, etal., Mod Rheumatol. 2003 Jun;13(2):129-34. doi: 10.3109/s10165-002-0211-8.
13. Hepatocyte growth factor accelerates the proliferation of hepatic oval cells and possibly promotes the differentiation in a 2-acetylaminofluorene/partial hepatectomy model in rats. Hasuike S, etal., J Gastroenterol Hepatol. 2005 Nov;20(11):1753-61.
14. Intravitreous levels of hepatocyte growth factor/scatter factor and vascular cell adhesion molecule-1 in the vitreous fluid of diabetic patients with proliferative retinopathy. Hernandez C, etal., Diabetes Metab. 2004 Sep;30(4):341-6.
15. Strong association between serum hepatocyte growth factor and metabolic syndrome. Hiratsuka A, etal., J Clin Endocrinol Metab. 2005 May;90(5):2927-31. Epub 2005 Feb 15.
16. Association of hepatocyte growth factor promoter polymorphism with severity of interstitial lung disease in Japanese patients with systemic sclerosis. Hoshino K, etal., Arthritis Rheum. 2011 Aug;63(8):2465-72. doi: 10.1002/art.30415.
17. Differences in the temporal expression of regulatory growth factors during choroidal neovascular development. Hu W, etal., Exp Eye Res. 2009 Jan;88(1):79-91. doi: 10.1016/j.exer.2008.10.014. Epub 2008 Nov 1.
18. Hepatocyte growth factor ameliorates dermal sclerosis in the tight-skin mouse model of scleroderma. Iwasaki T, etal., Arthritis Res Ther. 2006;8(6):R161.
19. Hepatocyte growth factor genetic variations and primary angle-closure glaucoma in the Han Chinese population. Jiang Z, etal., PLoS One. 2013 Apr 9;8(4):e60950. doi: 10.1371/journal.pone.0060950. Print 2013.
20. [Serum hepatocyte growth factor (HGF) in patients with inflammatory myopathies]. Kadoya A, etal., Nihon Rinsho Meneki Gakkai Kaishi. 1996 Oct;19(5):488-97.
21. Hepatocyte growth factor gene therapy slows down the progression of diabetic nephropathy in db/db mice. Kagawa T, etal., Nephron Physiol. 2006;102(3-4):p92-102. Epub 2005 Dec 6.
22. Nonviral gene transfer of human hepatocyte growth factor improves streptozotocin-induced diabetic neuropathy in rats. Kato N, etal., Diabetes. 2005 Mar;54(3):846-54.
23. Reduced high serum hepatocyte growth factor levels after successful cardioversion in patients with atrial fibrillation. Katoh H, etal., Clin Exp Pharmacol Physiol. 2004 Mar;31(3):145-51.
24. Increase in the circulating level of hepatocyte growth factor in pancreatic cancer patients. Kemik O, etal., Bratisl Lek Listy. 2009;110(10):627-9.
25. c-Met expression as an indicator of survival outcome in patients with oral tongue carcinoma. Kim CH, etal., Head Neck. 2010 Dec;32(12):1655-64. doi: 10.1002/hed.21383.
26. Hepatocyte growth factor promotes endogenous repair and functional recovery after spinal cord injury. Kitamura K, etal., J Neurosci Res. 2007 Aug 15;85(11):2332-42.
27. Human hepatocyte growth factor promotes functional recovery in primates after spinal cord injury. Kitamura K, etal., PLoS One. 2011;6(11):e27706. doi: 10.1371/journal.pone.0027706. Epub 2011 Nov 29.
28. Role of fibroblast-derived growth factors in regulating hyperpigmentation of solar lentigo. Kovacs D, etal., Br J Dermatol. 2010 Nov;163(5):1020-7. doi: 10.1111/j.1365-2133.2010.09946.x.
29. Acceleration of wound healing by combined gene transfer of hepatocyte growth factor and prostacyclin synthase with Shima Jet. Kunugiza Y, etal., Gene Ther. 2006 Aug;13(15):1143-52. Epub 2006 Mar 30.
30. Suppression of progressive loss of coat color in microphthalmia-vitiligo mutant mice. Kurita K, etal., J Invest Dermatol. 2005 Sep;125(3):538-44.
31. Hepatocyte growth factor ameliorates acute graft-versus-host disease and promotes hematopoietic function. Kuroiwa T, etal., J Clin Invest. 2001 Jun;107(11):1365-73.
32. Unique epithelial cell production of hepatocyte growth factor/scatter factor by putative precancerous intestinal metaplasias and associated "intestinal-type" biliary cancer chemically induced in rat liver. Lai GH, etal., Hepatology. 2000 Jun;31(6):1257-65.
33. Vascular endothelial growth factor and hepatocyte growth factor levels are differentially elevated in patients with advanced retinopathy of prematurity. Lashkari K, etal., Am J Pathol. 2000 Apr;156(4):1337-44.
34. [Tubular epithelial-myofibroblast transdifferentiation and expressions of hepatocyte growth factor and Smad7 in renal tissues of rat with experimental diabetes] Liu QJ, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2005 Nov;17(11):675-8.
35. Neuroprotective effect of hepatocyte growth factor against photoreceptor degeneration in rats. Machida S, etal., Invest Ophthalmol Vis Sci. 2004 Nov;45(11):4174-82.
36. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
37. MGDs mouse GO annotations MGD data from the GO Consortium
38. MGD IEA MGD IEA
39. Angiogenic gene cell therapy using suicide gene system regulates the effect of angiogenesis in infarcted rat heart. Miyagawa S, etal., Transplantation. 2006 Mar 27;81(6):902-7.
40. Safety evaluation of clinical gene therapy using hepatocyte growth factor to treat peripheral arterial disease. Morishita R, etal., Hypertension. 2004 Aug;44(2):203-9. Epub 2004 Jul 6.
41. Association between hepatocyte growth factor gene polymorphism and essential hypertension. Motone M, etal., Hypertens Res. 2004 Apr;27(4):247-51.
42. Co-expression of different angiogenic factors in external auditory canal cholesteatoma. Naim R, etal., Acta Otolaryngol. 2004 Jun;124(5):563-8.
43. A novel nude mouse model of liver metastasis and peritoneal dissemination from the same human pancreatic cancer line. Nishimori H, etal., Pancreas. 2002 Apr;24(3):242-50.
44. Serum hepatocyte growth factor as a possible indicator of arteriosclerosis. Nishimura M, etal., J Hypertens. 1997 Oct;15(10):1137-42.
45. Accelerated ultraviolet radiation-induced carcinogenesis in hepatocyte growth factor/scatter factor transgenic mice. Noonan FP, etal., Cancer Res. 2000 Jul 15;60(14):3738-43.
46. A comparison of the levels of hepatocyte growth factor in serum in patients with type 1 diabetes mellitus with different stages of diabetic retinopathy. Nowak M, etal., Endokrynol Pol. 2008 Jan-Feb;59(1):2-5.
47. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
48. Involvement of hepatocyte growth factor in the development of bone metastasis of a mouse mammary cancer cell line, BALB/c-MC. Ono K, etal., Bone. 2006 Jul;39(1):27-34. Epub 2006 Feb 3.
49. Intrathecal injection of HVJ-E containing HGF gene to cerebrospinal fluid can prevent and ameliorate hearing impairment in rats. Oshima K, etal., FASEB J. 2004 Jan;18(1):212-4. Epub 2003 Nov 20.
50. c-Met autocrine activation induces development of malignant melanoma and acquisition of the metastatic phenotype. Otsuka T, etal., Cancer Res. 1998 Nov 15;58(22):5157-67.
51. Disassociation of met-mediated biological responses in vivo: the natural hepatocyte growth factor/scatter factor splice variant NK2 antagonizes growth but facilitates metastasis. Otsuka T, etal., Mol Cell Biol. 2000 Mar;20(6):2055-65.
52. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
53. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
54. Hepatocyte growth factor and c-MET in benign and malignant peripheral nerve sheath tumors. Rao UN, etal., Hum Pathol. 1997 Sep;28(9):1066-70.
55. Obesity is associated with increased levels of circulating hepatocyte growth factor. Rehman J, etal., J Am Coll Cardiol. 2003 Apr 16;41(8):1408-13.
56. Mouse MP Annotation Import Pipeline RGD automated import pipeline
57. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
58. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
59. Overexpression of hepatocyte growth factor and its receptor c-Met in nasal polyps. Rho HS, etal., Arch Otolaryngol Head Neck Surg. 2006 Sep;132(9):985-9.
60. Proteinase and growth factor alterations revealed by gene microarray analysis of human diabetic corneas. Saghizadeh M, etal., Invest Ophthalmol Vis Sci. 2005 Oct;46(10):3604-15.
61. Association of the hepatocyte growth factor gene with keratoconus in an Australian population. Sahebjada S, etal., PLoS One. 2014 Jan 8;9(1):e84067. doi: 10.1371/journal.pone.0084067. eCollection 2014.
62. Aqueous humor levels of hepatocyte growth factor in retinitis pigmentosa. Salom D, etal., Invest Ophthalmol Vis Sci. 2010 Jun;51(6):3157-61. doi: 10.1167/iovs.09-4390. Epub 2010 Jan 6.
63. Clinical significance of circulating hepatocyte growth factor, a new risk marker of carotid atherosclerosis in patients with Type 2 diabetes. Satani K, etal., Diabet Med. 2006 Jun;23(6):617-22.
64. Noncoding mutations of HGF are associated with nonsyndromic hearing loss, DFNB39. Schultz JM, etal., Am J Hum Genet. 2009 Jul;85(1):25-39. doi: 10.1016/j.ajhg.2009.06.003. Epub 2009 Jul 2.
65. Expression and neuroprotective effect of hepatocyte growth factor in retinal ischemia-reperfusion injury. Shibuki H, etal., Invest Ophthalmol Vis Sci. 2002 Feb;43(2):528-36.
66. Serum hepatocyte growth factor predicts ventricular remodeling following myocardial infarction. Soeki T, etal., Circ J. 2002 Nov;66(11):1003-7.
67. Gallbladder cancer treatment using adenovirus expressing the HGF/NK4 gene in a peritoneal implantation model. Tanaka T, etal., Cancer Gene Ther. 2004 Jun;11(6):431-40.
68. Hepatocyte growth factor protects retinal ganglion cells by increasing neuronal survival and axonal regeneration in vitro and in vivo. Tonges L, etal., J Neurochem. 2011 Jun;117(5):892-903. doi: 10.1111/j.1471-4159.2011.07257.x. Epub 2011 Apr 26.
69. Hepatocyte growth factor in cerebrospinal fluid in neurologic disease. Tsuboi Y, etal., Acta Neurol Scand. 2002 Aug;106(2):99-103.
70. Nonviral retrograde gene transfer of human hepatocyte growth factor improves neuropathic pain-related phenomena in rats. Tsuchihara T, etal., Mol Ther. 2009 Jan;17(1):42-50. doi: 10.1038/mt.2008.214. Epub 2008 Oct 21.
71. High myopia is not associated with the SNPs in the TGIF, lumican, TGFB1, and HGF genes. Wang P, etal., Invest Ophthalmol Vis Sci. 2009 Apr;50(4):1546-51. doi: 10.1167/iovs.08-2537. Epub 2008 Dec 5.
72. Metabolism of hepatocyte growth factor in the heart in patients with coronary artery disease: implication for coronary arteriosclerosis. Watanabe K, etal., Cardiovasc Drugs Ther. 2001 Mar;15(2):147-53.
73. Hepatocyte growth factor both prevents and ameliorates the symptoms of dermal sclerosis in a mouse model of scleroderma. Wu MH, etal., Gene Ther. 2004 Jan;11(2):170-80.
74. Recombinant human hepatocyte growth factor facilitates biliary transport after hepatocyte transplantation in Eisai hyperbilirubinemic rats. Yamaguchi Y, etal., Dig Dis Sci. 1997 Mar;42(3):522-8.
75. Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19. Yang Y, etal., J Allergy Clin Immunol. 2020 Apr 29. pii: S0091-6749(20)30576-5. doi: 10.1016/j.jaci.2020.04.027.
76. Hepatocyte growth factor and myopia: genetic association analyses in a Caucasian population. Yanovitch T, etal., Mol Vis. 2009 May 20;15:1028-35.
77. [Expression and significances of FSCN1 and HGF in nasal inverted papilloma]. Yuan L, etal., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012 Apr;26(8):339-42.
78. Novel therapeutic strategy for stroke in rats by bone marrow stromal cells and ex vivo HGF gene transfer with HSV-1 vector. Zhao MZ, etal., J Cereb Blood Flow Metab. 2006 Sep;26(9):1176-88. Epub 2006 Jan 18.
Additional References at PubMed
PMID:1385703   PMID:1406687   PMID:1535333   PMID:1831975   PMID:2142751   PMID:2144630   PMID:7474919   PMID:7490100   PMID:7559778   PMID:7651534   PMID:7822318   PMID:7822413  
PMID:7851897   PMID:7854452   PMID:7854453   PMID:7929565   PMID:7935420   PMID:7988745   PMID:8034747   PMID:8039703   PMID:8071312   PMID:8081873   PMID:8135822   PMID:8138271  
PMID:8179615   PMID:8197126   PMID:8200486   PMID:8241272   PMID:8307976   PMID:8408200   PMID:8620851   PMID:8631159   PMID:8633043   PMID:8635233   PMID:8650184   PMID:8681797  
PMID:8791524   PMID:8824331   PMID:8930401   PMID:8982163   PMID:9012848   PMID:9166406   PMID:9203584   PMID:9362368   PMID:9367820   PMID:9417075   PMID:9474750   PMID:9488442  
PMID:9540971   PMID:9576745   PMID:9620689   PMID:10064822   PMID:10079225   PMID:10349636   PMID:10352021   PMID:10364163   PMID:10551403   PMID:10588868   PMID:10625667   PMID:10641789  
PMID:10652269   PMID:10704889   PMID:10725250   PMID:10727259   PMID:10842060   PMID:10843805   PMID:10888866   PMID:10951502   PMID:11032833   PMID:11042159   PMID:11061428   PMID:11076861  
PMID:11217851   PMID:11248243   PMID:11310823   PMID:11343646   PMID:11375907   PMID:11707776   PMID:11723058   PMID:11746958   PMID:11761336   PMID:11784715   PMID:11809759   PMID:11836782  
PMID:11896611   PMID:11948403   PMID:12115601   PMID:12130561   PMID:12193542   PMID:12193555   PMID:12351166   PMID:12368906   PMID:12397180   PMID:12466851   PMID:12477932   PMID:12482598  
PMID:12542542   PMID:12670907   PMID:12702649   PMID:12878170   PMID:12915117   PMID:14500721   PMID:14517989   PMID:14550779   PMID:14576199   PMID:14607778   PMID:14623241   PMID:14625309  
PMID:14681479   PMID:14694163   PMID:14759494   PMID:15072590   PMID:15221943   PMID:15261829   PMID:15314156   PMID:15383179   PMID:15555922   PMID:15576826   PMID:15841179   PMID:15856015  
PMID:16079293   PMID:16103912   PMID:16141072   PMID:16141073   PMID:16144866   PMID:16177122   PMID:16247031   PMID:16380478   PMID:16400035   PMID:16403606   PMID:16424394   PMID:16476577  
PMID:16513678   PMID:16602821   PMID:16648972   PMID:16651617   PMID:16840775   PMID:16877364   PMID:16880525   PMID:17068118   PMID:17170214   PMID:17203235   PMID:17215404   PMID:17241389  
PMID:17258200   PMID:17412827   PMID:17561000   PMID:17583691   PMID:17688880   PMID:17699753   PMID:17702746   PMID:17761834   PMID:17804794   PMID:17901400   PMID:17923692   PMID:17976157  
PMID:18032545   PMID:18073323   PMID:18287559   PMID:18362143   PMID:18395096   PMID:18495663   PMID:18504429   PMID:18524894   PMID:18628208   PMID:18697905   PMID:18820214   PMID:18829539  
PMID:18922968   PMID:18973760   PMID:18988920   PMID:19020551   PMID:19071214   PMID:19098908   PMID:19234748   PMID:19249600   PMID:19330341   PMID:19393645   PMID:19448157   PMID:19470725  
PMID:19812386   PMID:19853659   PMID:20040596   PMID:20060823   PMID:20147731   PMID:20332205   PMID:20375988   PMID:20382450   PMID:20442248   PMID:20506405   PMID:20508974   PMID:20596656  
PMID:20624990   PMID:20639480   PMID:20649939   PMID:20843830   PMID:20852387   PMID:20934536   PMID:21068842   PMID:21072211   PMID:21094172   PMID:21148681   PMID:21187969   PMID:21199531  
PMID:21209281   PMID:21292498   PMID:21293003   PMID:21554929   PMID:21595927   PMID:21666233   PMID:21683144   PMID:21703184   PMID:21784852   PMID:21873635   PMID:21940662   PMID:22001117  
PMID:22035642   PMID:22095660   PMID:22245998   PMID:22287599   PMID:22318499   PMID:22427375   PMID:22441736   PMID:22535512   PMID:22627288   PMID:22682244   PMID:22740630   PMID:22987640  
PMID:22996389   PMID:23024263   PMID:23041440   PMID:23064365   PMID:23070814   PMID:23077169   PMID:23224784   PMID:23229794   PMID:23233163   PMID:23293024   PMID:23376422   PMID:23459311  
PMID:23485708   PMID:23527275   PMID:23548689   PMID:23560074   PMID:23627689   PMID:23722408   PMID:23723997   PMID:23773083   PMID:23840657   PMID:23886856   PMID:23922381   PMID:23934123  
PMID:23951403   PMID:23994610   PMID:24089510   PMID:24223113   PMID:24224701   PMID:24246674   PMID:24302003   PMID:24349415   PMID:24469707   PMID:24569592   PMID:24618323   PMID:24634221  
PMID:24685580   PMID:24692544   PMID:24811579   PMID:24865428   PMID:24959005   PMID:25114100   PMID:25116473   PMID:25362352   PMID:25503558   PMID:25510828   PMID:25521737   PMID:25571972  
PMID:25586556   PMID:25905717   PMID:25906153   PMID:25938594   PMID:26001768   PMID:26093299   PMID:26165517   PMID:26275053   PMID:26290232   PMID:26393505   PMID:26551462   PMID:26728565  
PMID:26739889   PMID:26764350   PMID:26818605   PMID:26875548   PMID:27030285   PMID:27109105   PMID:27143995   PMID:27388243   PMID:27488639   PMID:27779646   PMID:28218627   PMID:28270618  
PMID:28429746   PMID:28542142   PMID:28758209   PMID:28838957   PMID:28855398   PMID:28864680   PMID:28969681   PMID:29040876   PMID:29343699   PMID:29436622   PMID:29771943   PMID:29928062  
PMID:30022023   PMID:30066918   PMID:30103949   PMID:30242894   PMID:30401749   PMID:30627913   PMID:30861238   PMID:31115492   PMID:31212972   PMID:31221639   PMID:31338035   PMID:31535973  
PMID:31972251   PMID:32152201   PMID:32204446   PMID:32258116   PMID:32325033   PMID:32522231   PMID:32539223   PMID:32983173   PMID:33455972   PMID:33635004   PMID:33930309   PMID:34819402  
PMID:35093804   PMID:35568059   PMID:36154712   PMID:36198802   PMID:36227576   PMID:36293268   PMID:36538176   PMID:36573461   PMID:36799689   PMID:37642183   PMID:37913847   PMID:37981065  


Genomics

Comparative Map Data
Hgf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39516,758,493 - 16,827,448 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl516,758,493 - 16,825,150 (+)EnsemblGRCm39 Ensembl
GRCm38516,553,495 - 16,619,439 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl516,553,495 - 16,620,152 (+)EnsemblGRCm38mm10GRCm38
MGSCv37516,059,368 - 16,125,257 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36516,065,374 - 16,131,263 (+)NCBIMGSCv36mm8
Celera513,552,002 - 13,617,800 (+)NCBICelera
Cytogenetic Map5A3NCBI
cM Map57.07NCBI
HGF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38781,699,010 - 81,770,047 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl781,699,010 - 81,770,438 (-)EnsemblGRCh38hg38GRCh38
GRCh37781,328,326 - 81,399,363 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36781,169,380 - 81,237,388 (-)NCBINCBI36Build 36hg18NCBI36
Build 34781,024,867 - 81,044,103NCBI
Celera776,032,788 - 76,100,524 (-)NCBICelera
Cytogenetic Map7q21.11NCBI
HuRef775,935,402 - 76,003,191 (-)NCBIHuRef
CHM1_1781,261,794 - 81,329,511 (-)NCBICHM1_1
T2T-CHM13v2.0782,951,060 - 83,022,099 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2780,663,506 - 80,731,238 (-)NCBI
Hgf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8419,628,902 - 19,700,467 (-)NCBIGRCr8
mRatBN7.2418,673,736 - 18,745,582 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl418,677,101 - 18,745,409 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx423,828,584 - 23,896,754 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0419,645,467 - 19,713,646 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0418,026,554 - 18,094,730 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0415,435,460 - 15,505,377 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl415,433,295 - 15,505,362 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0415,408,857 - 15,478,988 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4414,864,357 - 14,932,513 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1414,864,356 - 14,932,513 (-)NCBI
Celera414,212,976 - 14,281,167 (-)NCBICelera
Cytogenetic Map4q12NCBI
Hgf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554104,114,778 - 4,182,058 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554104,114,280 - 4,181,953 (+)NCBIChiLan1.0ChiLan1.0
HGF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2699,548,718 - 99,620,089 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17147,813,354 - 147,884,422 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0773,667,618 - 73,738,960 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1787,325,741 - 87,396,850 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl787,327,798 - 87,397,811 (-)Ensemblpanpan1.1panPan2
HGF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11821,329,688 - 21,410,257 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1821,332,817 - 21,410,263 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1821,005,145 - 21,082,437 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01821,778,181 - 21,858,827 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1821,778,229 - 21,858,761 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11821,417,964 - 21,495,307 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01820,953,619 - 21,030,809 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01821,607,548 - 21,684,870 (-)NCBIUU_Cfam_GSD_1.0
Hgf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511863,151,279 - 63,227,083 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936734356,115 - 428,779 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936734354,798 - 428,356 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HGF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl998,438,143 - 98,513,564 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1998,437,771 - 98,513,573 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29108,765,929 - 108,841,386 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HGF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12167,118,785 - 67,193,506 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2167,120,722 - 67,193,504 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604236,762,736 - 36,834,784 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hgf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473930,236,146 - 30,307,356 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473930,233,589 - 30,307,508 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hgf
2557 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:134
Count of miRNA genes:109
Interacting mature miRNAs:126
Transcripts:ENSMUST00000030683
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141234Pbwg14_mpostnatal body weight growth 14 (mouse)Not determined5121273552Mouse
1301468Eye1_meye weight 1 (mouse)Not determined5121929650Mouse
10412081Bwq13_mbody weight QTL 13 (mouse)Not determined5123606323Mouse
12904958Gmmq8_mgastrocnemius muscle mass QTL 8 (mouse)5129421124Mouse
10401122Pgia41_mproteoglycan induced arthritis 41 (mouse)Not determined582314434823280Mouse
12738412Lfibq4_mliver fibrosis QTL 4 (mouse)5315000020799180Mouse
15039371Nmrs21_mNAFLD-associated magnetic resonance shift 21 (mouse)5350482337504823Mouse
13442491Mecth1_mmechanosensation threshold 1 (mouse)5451800019834998Mouse
1301806Actd2_mactivity-distance traveled 2 (mouse)Not determined5538452039384652Mouse
4141207Imrfq1_mimmune response to Factor IX QTL 1 (mouse)Not determined5812411742124239Mouse
7394748Mom5_mmodifier of Min 5 (mouse)Not determined5884767233475637Mouse
1301693Sle6_msystemic lupus erythematosus susceptibility 6 (mouse)Not determined5889069387841837Mouse
1357478Kdnw1_mkidney weight 1 (mouse)Not determined5891594940529869Mouse
14696730Kidlq1_mkidney weight, left QTL 1 (mouse)51356315247563152Mouse
1301685Estq2_mestradiol regulated response QTL 2 (mouse)Not determined51563408449634190Mouse

Markers in Region
Hgf  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37516,058,089 - 16,058,291UniSTSGRCm37
Celera513,550,723 - 13,550,925UniSTS
Cytogenetic Map5A2-A3UniSTS
cM Map54.0UniSTS
Hgf  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5A2-A3UniSTS
cM Map54.0UniSTS
Hgf  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5A2-A3UniSTS
cM Map54.0UniSTS
Hgf  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5A2-A3UniSTS
Hgf  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5A2-A3UniSTS
Hgf  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38516,552,271 - 16,552,473UniSTSGRCm38
MGSCv37516,058,089 - 16,058,291UniSTSGRCm37
Celera513,550,723 - 13,550,925UniSTS
Cytogenetic Map5A2-A3UniSTS
cM Map54.0UniSTS
Hgf  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5A2-A3UniSTS
Hgf  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5A2-A3UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001289458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001289459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001289460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001289461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC161176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF042856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK033274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK042121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK052289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK082461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK142159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC119228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC144764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D10212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D10213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L25131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S71816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X72307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X81630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X84046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000030683   ⟹   ENSMUSP00000030683
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl516,758,784 - 16,824,304 (+)Ensembl
GRCm38.p6 Ensembl516,553,786 - 16,619,306 (+)Ensembl
RefSeq Acc Id: ENSMUST00000195957
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl516,758,493 - 16,778,432 (+)Ensembl
GRCm38.p6 Ensembl516,553,495 - 16,573,434 (+)Ensembl
RefSeq Acc Id: ENSMUST00000196645   ⟹   ENSMUSP00000142517
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl516,758,926 - 16,824,008 (+)Ensembl
GRCm38.p6 Ensembl516,553,928 - 16,619,010 (+)Ensembl
RefSeq Acc Id: ENSMUST00000199581   ⟹   ENSMUSP00000143424
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl516,758,548 - 16,825,150 (+)Ensembl
GRCm38.p6 Ensembl516,553,550 - 16,620,152 (+)Ensembl
RefSeq Acc Id: ENSMUST00000199900
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl516,758,749 - 16,774,572 (+)Ensembl
GRCm38.p6 Ensembl516,553,751 - 16,569,574 (+)Ensembl
RefSeq Acc Id: ENSMUST00000200189
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl516,758,577 - 16,773,999 (+)Ensembl
GRCm38.p6 Ensembl516,553,579 - 16,569,001 (+)Ensembl
RefSeq Acc Id: NM_001289458   ⟹   NP_001276387
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39516,758,493 - 16,824,437 (+)NCBI
GRCm38516,553,495 - 16,619,439 (+)NCBI
Celera513,551,947 - 13,617,800 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001289459   ⟹   NP_001276388
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39516,758,493 - 16,824,437 (+)NCBI
GRCm38516,553,495 - 16,619,439 (+)NCBI
Celera513,551,947 - 13,617,800 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001289460   ⟹   NP_001276389
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39516,758,493 - 16,778,942 (+)NCBI
GRCm38516,553,495 - 16,573,944 (+)NCBI
Celera513,551,947 - 13,617,800 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001289461   ⟹   NP_001276390
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39516,758,899 - 16,824,437 (+)NCBI
GRCm38516,553,901 - 16,619,439 (+)NCBI
Celera513,551,947 - 13,617,800 (+)NCBI
Sequence:
RefSeq Acc Id: NM_010427   ⟹   NP_034557
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39516,758,493 - 16,824,437 (+)NCBI
GRCm38516,553,495 - 16,619,439 (+)NCBI
MGSCv37516,059,368 - 16,125,257 (+)RGD
Celera513,551,947 - 13,617,800 (+)NCBI
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036164820   ⟹   XP_036020713
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39516,758,841 - 16,827,448 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_034557   ⟸   NM_010427
- Peptide Label: isoform 1 preproprotein
- UniProtKB: Q64007 (UniProtKB/Swiss-Prot),   Q61662 (UniProtKB/Swiss-Prot),   Q53WS5 (UniProtKB/Swiss-Prot),   O55027 (UniProtKB/Swiss-Prot),   Q6LBE6 (UniProtKB/Swiss-Prot),   Q08048 (UniProtKB/Swiss-Prot),   Q8C9G5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001276387   ⟸   NM_001289458
- Peptide Label: isoform 1 preproprotein
- UniProtKB: Q64007 (UniProtKB/Swiss-Prot),   Q61662 (UniProtKB/Swiss-Prot),   Q53WS5 (UniProtKB/Swiss-Prot),   O55027 (UniProtKB/Swiss-Prot),   Q6LBE6 (UniProtKB/Swiss-Prot),   Q08048 (UniProtKB/Swiss-Prot),   Q8C9G5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001276388   ⟸   NM_001289459
- Peptide Label: isoform 1 preproprotein
- UniProtKB: Q64007 (UniProtKB/Swiss-Prot),   Q61662 (UniProtKB/Swiss-Prot),   Q53WS5 (UniProtKB/Swiss-Prot),   O55027 (UniProtKB/Swiss-Prot),   Q6LBE6 (UniProtKB/Swiss-Prot),   Q08048 (UniProtKB/Swiss-Prot),   Q8C9G5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001276389   ⟸   NM_001289460
- Peptide Label: isoform 2 precursor
- UniProtKB: Q08048 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001276390   ⟸   NM_001289461
- Peptide Label: isoform 3 preproprotein
- UniProtKB: Q8C9G5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000143424   ⟸   ENSMUST00000199581
RefSeq Acc Id: ENSMUSP00000030683   ⟸   ENSMUST00000030683
RefSeq Acc Id: ENSMUSP00000142517   ⟸   ENSMUST00000196645
RefSeq Acc Id: XP_036020713   ⟸   XM_036164820
- Peptide Label: isoform X1
- UniProtKB: Q64007 (UniProtKB/Swiss-Prot),   Q61662 (UniProtKB/Swiss-Prot),   Q53WS5 (UniProtKB/Swiss-Prot),   Q08048 (UniProtKB/Swiss-Prot),   O55027 (UniProtKB/Swiss-Prot),   Q6LBE6 (UniProtKB/Swiss-Prot),   Q8C9G5 (UniProtKB/TrEMBL)
Protein Domains
Apple   Kringle   PAN   Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q08048-F1-model_v2 AlphaFold Q08048 1-728 view protein structure

Promoters
RGD ID:6837697
Promoter ID:MM_KWN:41441
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   BoneMarrow_0Hour,   BoneMarrow_4Hour,   Lung
Transcripts:NM_010427,   UC008WND.1,   UC008WNE.1,   UC008WNG.1,   UC008WNH.1,   UC008WNI.1,   UC008WNJ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36516,058,916 - 16,059,682 (+)MPROMDB
RGD ID:6886026
Promoter ID:EPDNEW_M6464
Type:initiation region
Name:Hgf_1
Description:Mus musculus hepatocyte growth factor , transcript variant 5,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38516,553,866 - 16,553,926EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96079 AgrOrtholog
Ensembl Genes ENSMUSG00000028864 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000030683 ENTREZGENE
  ENSMUST00000030683.8 UniProtKB/Swiss-Prot
  ENSMUST00000196645 ENTREZGENE
  ENSMUST00000196645.2 UniProtKB/Swiss-Prot
  ENSMUST00000199581 ENTREZGENE
  ENSMUST00000199581.5 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.40.20.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hepatocyte Growth Factor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Hepatocyte_GF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HGF-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pan_app UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:15234 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:96079 ENTREZGENE
NCBI Gene 15234 ENTREZGENE
PANTHER HEPATOCYTE GROWTH FACTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLASMINOGEN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Kringle UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hgf PhenoGen
PIRSF Hepatocyte_GF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HGF_MST1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KRINGLE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE KRINGLE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KRINGLE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PAN_AP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00130 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Hairpin loop containing domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57440 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt HGF_MOUSE UniProtKB/Swiss-Prot
  O55027 ENTREZGENE
  Q08048 ENTREZGENE
  Q53WS5 ENTREZGENE
  Q61662 ENTREZGENE
  Q64007 ENTREZGENE
  Q6LBE6 ENTREZGENE
  Q8C4E2_MOUSE UniProtKB/TrEMBL
  Q8C9G5 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary O55027 UniProtKB/Swiss-Prot
  Q53WS5 UniProtKB/Swiss-Prot
  Q61662 UniProtKB/Swiss-Prot
  Q64007 UniProtKB/Swiss-Prot
  Q6LBE6 UniProtKB/Swiss-Prot