1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine increases expression EXP 6480464 chlorcyclizine results in increased expression of PIK3R1 mRNA CTD PMID:21058326 17beta-estradiol decreases expression EXP 6480464 Estradiol results in decreased expression of PIK3R1 protein CTD PMID:22142692 17beta-estradiol decreases expression ISO RGD:11103 6480464 Estradiol results in decreased expression of PIK3R1 mRNA CTD PMID:25210133 17beta-estradiol multiple interactions ISO RGD:11103 6480464 ESR1 protein promotes the reaction [Estradiol results in decreased expression of PIK3R1 mRNA] CTD PMID:25210133 17beta-estradiol 3-benzoate increases methylation EXP 6480464 estradiol 3-benzoate results in increased methylation of PIK3R1 promoter CTD PMID:27415467 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:11103 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:731958 6480464 Tetrachlorodibenzodioxin results in increased expression of PIK3R1 mRNA CTD PMID:17101203 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:11103 6480464 Tetrachlorodibenzodioxin results in decreased expression of PIK3R1 mRNA CTD PMID:19770486 , PMID:22666406 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:11103 6480464 Tetrachlorodibenzodioxin affects the expression of PIK3R1 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:731958 6480464 Tetrachlorodibenzodioxin affects the expression of PIK3R1 mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of PIK3R1 mRNA CTD PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 AHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of PIK3R1 mRNA] CTD PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:11103 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:19654925 , PMID:28433925 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:11103 6480464 Tetrachlorodibenzodioxin results in increased expression of PIK3R1 mRNA CTD PMID:18691609 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:731958 6480464 Tetrachlorodibenzodioxin results in decreased expression of PIK3R1 mRNA CTD PMID:20106945 2-butoxyethanol increases expression ISO RGD:11103 6480464 n-butoxyethanol results in increased expression of PIK3R1 mRNA CTD PMID:19812364 3,3',4,4',5-pentachlorobiphenyl decreases expression EXP 6480464 3 more ... CTD PMID:23196670 3,3',4,4'-tetrachlorobiphenyl multiple interactions ISO RGD:11103 6480464 3 more ... CTD PMID:19467301 3-chloropropane-1,2-diol increases expression EXP 6480464 alpha-Chlorohydrin results in increased expression of PIK3R1 mRNA CTD PMID:28522335 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:731958 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PIK3R1 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of PIK3R1 mRNA CTD PMID:28628672 3-methyladenine multiple interactions ISO RGD:731958 6480464 3-methyladenine inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of PIK3R1 protein] CTD PMID:32043704 3-methylcholanthrene multiple interactions ISO RGD:731958 6480464 Methylcholanthrene promotes the reaction [AHR protein binds to PIK3R1 promoter] CTD PMID:20348232 3H-1,2-dithiole-3-thione decreases expression EXP 6480464 1, 2-dithiol-3-thione results in decreased expression of PIK3R1 mRNA CTD PMID:19162173 4-hydroxyphenyl retinamide decreases expression ISO RGD:11103 6480464 Fenretinide results in decreased expression of PIK3R1 mRNA CTD PMID:28973697 4-tert-butylphenol multiple interactions ISO RGD:731958 6480464 Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [butylphen results in increased abundance of Reactive Oxygen Species]] more ... CTD PMID:28836394 9-cis-retinoic acid increases expression ISO RGD:11103 6480464 Alitretinoin results in increased expression of PIK3R1 mRNA, Alitretinoin results in increased expression of PIK3R1 protein CTD PMID:16288212 acetylsalicylic acid decreases expression ISO RGD:731958 6480464 Aspirin results in decreased expression of PIK3R1 mRNA CTD PMID:20457246 acrylamide increases expression EXP 6480464 Acrylamide results in increased expression of PIK3R1 mRNA CTD PMID:22197712 aflatoxin B1 increases expression ISO RGD:11103 6480464 Aflatoxin B1 results in increased expression of PIK3R1 mRNA CTD PMID:19770486 aflatoxin B1 decreases methylation ISO RGD:731958 6480464 Aflatoxin B1 results in decreased methylation of PIK3R1 gene CTD PMID:27153756 aflatoxin B1 decreases expression ISO RGD:731958 6480464 Aflatoxin B1 results in decreased expression of PIK3R1 mRNA CTD PMID:27153756 aldehydo-D-glucose multiple interactions ISO RGD:731958 6480464 Glucose promotes the reaction [PIK3R1 protein binds to IRS1 protein] CTD PMID:10430617 all-trans-retinoic acid multiple interactions ISO RGD:11103 6480464 PIK3R1 protein promotes the reaction [Tretinoin results in increased activity of AKT1 protein] CTD PMID:16288212 all-trans-retinoic acid increases expression ISO RGD:731958 6480464 Tretinoin results in increased expression of PIK3R1 mRNA CTD PMID:23830798 all-trans-retinoic acid increases expression ISO RGD:11103 6480464 Tretinoin results in increased expression of PIK3R1 mRNA, Tretinoin results in increased expression of PIK3R1 protein CTD PMID:16288212 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of PIK3R1 mRNA CTD PMID:16483693 anthocyanin increases expression EXP 6480464 Anthocyanins results in increased expression of PIK3R1 mRNA CTD PMID:18803703 arecoline increases expression EXP 6480464 Arecoline results in increased expression of PIK3R1 mRNA CTD PMID:20724125 arsane decreases expression ISO RGD:731958 6480464 Arsenic results in decreased expression of PIK3R1 mRNA CTD PMID:19945496 arsenic atom decreases expression ISO RGD:731958 6480464 Arsenic results in decreased expression of PIK3R1 mRNA CTD PMID:19945496 arsenite(3-) multiple interactions ISO RGD:11103 6480464 arsenite promotes the reaction [PIK3R1 protein results in increased expression of HIF1A mRNA] more ... CTD PMID:20835880 arsenous acid decreases expression ISO RGD:11103 6480464 Arsenic Trioxide results in decreased expression of PIK3R1 mRNA CTD PMID:30032600 , PMID:30225639 arsenous acid increases expression ISO RGD:11103 6480464 Arsenic Trioxide results in increased expression of PIK3R1 mRNA CTD PMID:32112876 atazanavir sulfate multiple interactions ISO RGD:731958 6480464 [Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of PIK3R1 mRNA CTD PMID:32152650 atazanavir sulfate decreases expression ISO RGD:731958 6480464 Atazanavir Sulfate results in decreased expression of PIK3R1 mRNA CTD PMID:32152650 ATP multiple interactions ISO RGD:731958 6480464 Adenosine Triphosphate inhibits the reaction [resveratrol results in decreased activity of [PIK3R1 protein binds to PIK3CA protein]] CTD PMID:17550345 atrazine decreases expression ISO RGD:731958 6480464 Atrazine results in decreased expression of PIK3R1 mRNA CTD PMID:22378314 benzo[a]pyrene multiple interactions ISO RGD:11103 6480464 Benzoapyrene promotes the reaction [AHR protein binds to PIK3R1 promoter] CTD PMID:19654925 benzo[a]pyrene decreases methylation ISO RGD:731958 6480464 Benzoapyrene results in decreased methylation of PIK3R1 promoter CTD PMID:27901495 benzo[a]pyrene increases expression ISO RGD:11103 6480464 Benzoapyrene results in increased expression of PIK3R1 mRNA CTD PMID:23735875 benzo[a]pyrene decreases expression ISO RGD:11103 6480464 Benzoapyrene results in decreased expression of PIK3R1 mRNA CTD PMID:19770486 , PMID:22228805 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:731958 6480464 7 more ... CTD PMID:28529061 bexarotene multiple interactions ISO RGD:731958 6480464 bexarotene promotes the reaction [rosiglitazone results in increased expression of PIK3R1 mRNA] CTD PMID:10548525 bilirubin IXalpha decreases expression ISO RGD:731958 6480464 Bilirubin results in decreased expression of PIK3R1 mRNA CTD PMID:20196124 bis(2-chloroethyl) sulfide decreases expression ISO RGD:11103 6480464 Mustard Gas results in decreased expression of PIK3R1 mRNA CTD PMID:18955075 bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:11103 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 bisphenol A increases expression ISO RGD:731958 6480464 bisphenol A results in increased expression of PIK3R1 mRNA CTD PMID:21890461 bisphenol A multiple interactions ISO RGD:11103 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of PIK3R1 gene CTD PMID:28505145 bisphenol A multiple interactions ISO RGD:731958 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PIK3R1 mRNA CTD PMID:28628672 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of PIK3R1 mRNA CTD PMID:25181051 bisphenol A increases expression ISO RGD:11103 6480464 bisphenol A results in increased expression of PIK3R1 mRNA CTD PMID:25594700 , PMID:26063408 bisphenol A decreases expression ISO RGD:731958 6480464 bisphenol A results in decreased expression of PIK3R1 mRNA CTD PMID:22576693 bisphenol A increases methylation ISO RGD:731958 6480464 bisphenol A results in increased methylation of PIK3R1 gene CTD PMID:22576693 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of PIK3R1 protein CTD PMID:22142692 Bisphenol A diglycidyl ether multiple interactions ISO RGD:731958 6480464 2, 2-bis4-glycidyloxyphenylpropane inhibits the reaction [1-methylimino-N-oxy-6-2-morpholinoethoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester inhibits the reaction [VEGFA protein results in increased phosphorylation of PIK3R1 protein]] CTD PMID:21769449 bromobenzene decreases expression EXP 6480464 bromobenzene results in decreased expression of PIK3R1 mRNA CTD PMID:32479839 cadmium atom decreases expression ISO RGD:11103 6480464 Cadmium results in decreased expression of PIK3R1 mRNA CTD PMID:22666406 cantharidin decreases expression ISO RGD:731958 6480464 Cantharidin results in decreased expression of PIK3R1 protein modified form CTD PMID:31945315 capsaicin multiple interactions ISO RGD:11103 6480464 PIK3R1 gene mutant form inhibits the reaction [NGF protein results in increased susceptibility to Capsaicin] CTD PMID:17324588 capsazepine multiple interactions ISO RGD:11103 6480464 capsazepine inhibits the reaction [Olanzapine results in decreased expression of PIK3R1 mRNA] CTD PMID:32652086 carbamazepine affects expression ISO RGD:731958 6480464 Carbamazepine affects the expression of PIK3R1 mRNA CTD PMID:24752500 carbon nanotube decreases expression ISO RGD:11103 6480464 Nanotubes, Carbon analog results in decreased expression of PIK3R1 mRNA CTD PMID:21624382 celastrol decreases expression ISO RGD:731958 6480464 tripterine results in decreased expression of PIK3R1 mRNA CTD PMID:17010675 chenodeoxycholic acid multiple interactions ISO RGD:731958 6480464 [Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of PIK3R1 mRNA more ... CTD PMID:32152650 chlorogenic acid increases expression ISO RGD:11103 6480464 Chlorogenic Acid results in increased expression of PIK3R1 mRNA CTD PMID:21870829 chromium atom multiple interactions ISO RGD:11103 6480464 Chromium inhibits the reaction [Dietary Fats results in decreased expression of PIK3R1 protein] CTD PMID:20513351 ciguatoxin CTX1B affects expression ISO RGD:11103 6480464 Ciguatoxins affects the expression of PIK3R1 mRNA CTD PMID:18353800 cis-caffeic acid increases expression ISO RGD:11103 6480464 caffeic acid results in increased expression of PIK3R1 mRNA CTD PMID:21870829 cisplatin decreases response to substance ISO RGD:731958 6480464 PIK3R1 results in decreased susceptibility to Cisplatin CTD PMID:21571862 clobetasol increases expression ISO RGD:11103 6480464 Clobetasol results in increased expression of PIK3R1 mRNA CTD PMID:27462272 cobalt dichloride decreases expression ISO RGD:731958 6480464 cobaltous chloride results in decreased expression of PIK3R1 mRNA CTD PMID:19320972 coenzyme Q10 multiple interactions EXP 6480464 coenzyme Q10 inhibits the reaction [APP protein results in decreased expression of PIK3R1 protein] CTD PMID:22186599 conjugated linoleic acid decreases expression ISO RGD:731958 6480464 Linoleic Acids, Conjugated results in decreased expression of PIK3R1 protein CTD PMID:19800873 copper atom increases expression EXP 6480464 Copper results in increased expression of PIK3R1 mRNA CTD PMID:30556269 copper atom multiple interactions ISO RGD:731958 6480464 [Chelating Agents binds to Copper] inhibits the reaction [U 0126 results in increased expression of PIK3R1 protein modified form] more ... CTD PMID:30911355 copper(0) increases expression EXP 6480464 Copper results in increased expression of PIK3R1 mRNA CTD PMID:30556269 copper(0) multiple interactions ISO RGD:731958 6480464 [Chelating Agents binds to Copper] inhibits the reaction [U 0126 results in increased expression of PIK3R1 protein modified form] more ... CTD PMID:30911355 crocidolite asbestos decreases expression ISO RGD:11103 6480464 Asbestos, Crocidolite results in decreased expression of PIK3R1 mRNA CTD PMID:29279043 cyclosporin A decreases expression ISO RGD:11103 6480464 Cyclosporine results in decreased expression of PIK3R1 mRNA CTD PMID:19770486 , PMID:23830897 cyclosporin A multiple interactions ISO RGD:731958 6480464 [Cyclosporine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of PIK3R1 mRNA CTD PMID:32152650 cyclosporin A decreases expression ISO RGD:731958 6480464 Cyclosporine results in decreased expression of PIK3R1 mRNA CTD PMID:20106945 more ... D-glucose multiple interactions ISO RGD:731958 6480464 Glucose promotes the reaction [PIK3R1 protein binds to IRS1 protein] CTD PMID:10430617 daunorubicin affects response to substance ISO RGD:731958 6480464 PIK3R1 affects the susceptibility to Daunorubicin CTD PMID:17545624 deoxycholic acid multiple interactions ISO RGD:731958 6480464 [Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of PIK3R1 mRNA more ... CTD PMID:32152650 dexamethasone increases expression ISO RGD:731958 6480464 Dexamethasone results in increased expression of PIK3R1 mRNA, Dexamethasone results in increased expression of PIK3R1 protein CTD PMID:15576458 , PMID:25047013 dexamethasone multiple interactions ISO RGD:731958 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PIK3R1 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of PIK3R1 mRNA CTD PMID:28628672 dexamethasone affects response to substance ISO RGD:11103 6480464 PIK3R1 protein affects the susceptibility to Dexamethasone CTD PMID:22733784 dexamethasone multiple interactions ISO RGD:11103 6480464 naringin inhibits the reaction [Dexamethasone results in increased expression of PIK3R1 mRNA] more ... CTD PMID:22733784 more ... dexamethasone increases expression ISO RGD:11103 6480464 Dexamethasone results in increased expression of PIK3R1 more ... CTD PMID:22733784 more ... dexamethasone increases expression EXP 6480464 Dexamethasone results in increased expression of PIK3R1 mRNA CTD PMID:20032058 dexamethasone multiple interactions EXP 6480464 Testosterone inhibits the reaction [Dexamethasone results in increased expression of PIK3R1 mRNA] CTD PMID:20032058 diallyl trisulfide multiple interactions EXP 6480464 PIK3R1 protein promotes the reaction [diallyl trisulfide results in increased expression of HMOX1 protein], PIK3R1 protein promotes the reaction [diallyl trisulfide results in increased expression of NFE2L2 protein] CTD PMID:25896937 diarsenic trioxide decreases expression ISO RGD:11103 6480464 Arsenic Trioxide results in decreased expression of PIK3R1 mRNA CTD PMID:30032600 , PMID:30225639 diarsenic trioxide increases expression ISO RGD:11103 6480464 Arsenic Trioxide results in increased expression of PIK3R1 mRNA CTD PMID:32112876 dibenz[a,h]anthracene increases expression ISO RGD:11103 6480464 1 more ... CTD PMID:26377693 diclofenac affects expression ISO RGD:731958 6480464 Diclofenac affects the expression of PIK3R1 mRNA CTD PMID:24752500 diclofenac increases expression ISO RGD:11103 6480464 Diclofenac results in increased expression of PIK3R1 mRNA CTD PMID:26934552 dioxygen multiple interactions EXP 6480464 [Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased phosphorylation of PIK3R1 protein more ... CTD PMID:25352008 more ... dioxygen multiple interactions ISO RGD:11103 6480464 peoniflorin promotes the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased phosphorylation of PIK3R1 protein] CTD PMID:29560022 dioxygen decreases phosphorylation EXP 6480464 Oxygen deficiency results in decreased phosphorylation of PIK3R1 protein CTD PMID:25352008 dioxygen increases expression ISO RGD:731958 6480464 Oxygen deficiency results in increased expression of PIK3R1 mRNA CTD PMID:19640849 dioxygen multiple interactions ISO RGD:731958 6480464 PIK3R1 protein promotes the reaction [Oxygen deficiency results in increased expression of CD36 mRNA] more ... CTD PMID:19640849 dioxygen increases expression EXP 6480464 Oxygen deficiency results in increased expression of PIK3R1 mRNA CTD PMID:26476374 disodium selenite increases expression EXP 6480464 Sodium Selenite results in increased expression of PIK3R1 mRNA CTD PMID:14714311 diuron decreases expression EXP 6480464 Diuron results in decreased expression of PIK3R1 mRNA CTD PMID:21551480 dorsomorphin multiple interactions ISO RGD:731958 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in decreased expression of PIK3R1 mRNA CTD PMID:27188386 doxorubicin increases expression ISO RGD:11103 6480464 Doxorubicin results in increased expression of PIK3R1 mRNA CTD PMID:25896364 doxorubicin decreases expression ISO RGD:731958 6480464 Doxorubicin results in decreased expression of PIK3R1 mRNA CTD PMID:29803840 elemental selenium increases expression ISO RGD:11103 6480464 Selenium results in increased expression of PIK3R1 mRNA CTD PMID:28810182 emodin affects expression EXP 6480464 Emodin affects the expression of PIK3R1 protein CTD PMID:19549930 endosulfan increases phosphorylation ISO RGD:731958 6480464 Endosulfan results in increased phosphorylation of PIK3R1 protein CTD PMID:32044604 endosulfan decreases expression ISO RGD:731958 6480464 Endosulfan results in decreased expression of PIK3R1 mRNA CTD PMID:32044604 endosulfan multiple interactions ISO RGD:731958 6480464 2-4-morpholinyl-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Endosulfan results in increased phosphorylation of PIK3R1 protein] CTD PMID:32044604 entinostat decreases expression ISO RGD:731958 6480464 entinostat results in decreased expression of PIK3R1 mRNA CTD PMID:26272509 entinostat multiple interactions ISO RGD:731958 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in decreased expression of PIK3R1 mRNA CTD PMID:27188386 ethanol affects expression EXP 6480464 Ethanol affects the expression of PIK3R1 mRNA CTD PMID:11772933 ethanol affects splicing ISO RGD:11103 6480464 Ethanol affects the splicing of PIK3R1 mRNA CTD PMID:30319688 ethanol increases expression ISO RGD:11103 6480464 Ethanol results in increased expression of PIK3R1 protein CTD PMID:22459179 ethanol multiple interactions EXP 6480464 N-methyl-N-6-methoxy-1-phenyl-1 more ... CTD PMID:20655511 ethanol increases expression EXP 6480464 Ethanol results in increased expression of PIK3R1 mRNA CTD PMID:20655511 eugenol increases expression EXP 6480464 Eugenol results in increased expression of PIK3R1 mRNA CTD PMID:20724125 eugenol increases expression ISO RGD:11103 6480464 Eugenol results in increased expression of PIK3R1 mRNA CTD PMID:21870829 ferulic acid increases expression ISO RGD:11103 6480464 ferulic acid results in increased expression of PIK3R1 mRNA CTD PMID:21870829 folic acid affects expression ISO RGD:731958 6480464 Folic Acid affects the expression of PIK3R1 mRNA CTD PMID:16361273 folic acid decreases expression ISO RGD:11103 6480464 Folic Acid results in decreased expression of PIK3R1 mRNA CTD PMID:25629700 fonofos increases methylation ISO RGD:731958 6480464 Fonofos results in increased methylation of PIK3R1 promoter CTD PMID:22847954 formaldehyde decreases expression ISO RGD:731958 6480464 Formaldehyde results in decreased expression of PIK3R1 mRNA CTD PMID:20655997 formaldehyde increases expression ISO RGD:731958 6480464 Formaldehyde results in increased expression of PIK3R1 mRNA CTD PMID:23649840 fructose multiple interactions EXP 6480464 [Fructose co-treated with Dietary Fats] results in decreased expression of PIK3R1 protein CTD PMID:32259528 furan decreases expression EXP 6480464 furan results in decreased expression of PIK3R1 mRNA CTD PMID:25539665 Garcinol multiple interactions ISO RGD:731958 6480464 garcinol results in decreased phosphorylation of and results in decreased activity of PIK3R1 protein CTD PMID:16052481 gedunin decreases expression ISO RGD:731958 6480464 gedunin results in decreased expression of PIK3R1 mRNA CTD PMID:17010675 geldanamycin increases expression ISO RGD:731958 6480464 geldanamycin results in increased expression of PIK3R1 mRNA CTD PMID:26705709 geraniol multiple interactions EXP 6480464 geraniol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of PIK3R1 mRNA] CTD PMID:28428697 glucose multiple interactions ISO RGD:731958 6480464 Glucose promotes the reaction [PIK3R1 protein binds to IRS1 protein] CTD PMID:10430617 glycochenodeoxycholic acid multiple interactions ISO RGD:731958 6480464 [Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of PIK3R1 mRNA more ... CTD PMID:32152650 glycocholic acid multiple interactions ISO RGD:731958 6480464 [Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of PIK3R1 mRNA more ... CTD PMID:32152650 glycodeoxycholic acid multiple interactions ISO RGD:731958 6480464 [Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of PIK3R1 mRNA more ... CTD PMID:32152650 glyphosate decreases expression ISO RGD:731958 6480464 glyphosate results in decreased expression of PIK3R1 mRNA CTD PMID:31295307 gold atom multiple interactions ISO RGD:11103 6480464 [Gold co-treated with Polyethylene Glycols] results in increased expression of PIK3R1 mRNA CTD PMID:19695318 gold(0) multiple interactions ISO RGD:11103 6480464 [Gold co-treated with Polyethylene Glycols] results in increased expression of PIK3R1 mRNA CTD PMID:19695318 hesperidin multiple interactions EXP 6480464 Hesperidin inhibits the reaction [Diethylnitrosamine results in increased expression of PIK3R1 protein] CTD PMID:30779474 HU-308 multiple interactions EXP 6480464 HU 308 promotes the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased phosphorylation of PIK3R1 protein] CTD PMID:29560022 hydrazines decreases expression ISO RGD:11103 6480464 Hydrazines results in decreased expression of PIK3R1 mRNA CTD PMID:21647536 hydrogen peroxide increases phosphorylation ISO RGD:11103 6480464 Hydrogen Peroxide results in increased phosphorylation of PIK3R1 protein CTD PMID:27494022 hydrogen peroxide decreases phosphorylation ISO RGD:731958 6480464 Hydrogen Peroxide results in decreased phosphorylation of PIK3R1 protein CTD PMID:32043704 hydrogen peroxide multiple interactions ISO RGD:731958 6480464 3-methyladenine inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of PIK3R1 protein], KISS1 protein affects the reaction [Hydrogen Peroxide results in decreased phosphorylation of PIK3R1 protein] CTD PMID:32043704 hydroquinone multiple interactions ISO RGD:731958 6480464 Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [hydroquinone results in increased abundance of Reactive Oxygen Species]] more ... CTD PMID:28836394 indole-3-methanol affects expression EXP 6480464 indole-3-carbinol affects the expression of PIK3R1 mRNA CTD PMID:21396975 indometacin multiple interactions ISO RGD:731958 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PIK3R1 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of PIK3R1 mRNA CTD PMID:28628672 iron atom multiple interactions EXP 6480464 Iron promotes the reaction [MAP3K7 protein binds to HRAS protein binds to PIK3R1 protein] more ... CTD PMID:17172471 iron(0) multiple interactions EXP 6480464 Iron promotes the reaction [MAP3K7 protein binds to HRAS protein binds to PIK3R1 protein] more ... CTD PMID:17172471 iron(2+) sulfate (anhydrous) multiple interactions EXP 6480464 ferrous sulfate promotes the reaction [MAP3K7 protein binds to HRAS protein binds to PIK3R1 protein] more ... CTD PMID:17172471 isoprenaline increases expression ISO RGD:11103 6480464 Isoproterenol results in increased expression of PIK3R1 mRNA CTD PMID:20003209 L-ascorbic acid decreases expression EXP 6480464 Ascorbic Acid results in decreased expression of PIK3R1 mRNA CTD PMID:15372504 lead diacetate decreases expression EXP 6480464 lead acetate results in decreased expression of PIK3R1 mRNA CTD PMID:30980912 lead(0) affects expression ISO RGD:731958 6480464 Lead affects the expression of PIK3R1 mRNA CTD PMID:28903495 lead(2+) affects expression ISO RGD:731958 6480464 Lead affects the expression of PIK3R1 mRNA CTD PMID:28903495 linsidomine multiple interactions ISO RGD:11103 6480464 linsidomine inhibits the reaction [INS1 protein binds to PIK3R1 protein], linsidomine inhibits the reaction [INS1 protein results in increased activity of PIK3R1 protein] CTD PMID:19682478 LY294002 decreases expression ISO RGD:731958 6480464 2-4-morpholinyl-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of PIK3R1 protein modified form CTD PMID:30911355 LY294002 multiple interactions ISO RGD:731958 6480464 2-4-morpholinyl-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Endosulfan results in increased phosphorylation of PIK3R1 protein] CTD PMID:32044604 melphalan decreases expression ISO RGD:731958 6480464 Melphalan results in decreased expression of PIK3R1 mRNA CTD PMID:22363485 mercury atom decreases expression EXP 6480464 Mercury results in decreased expression of PIK3R1 mRNA CTD PMID:12730625 mercury(0) decreases expression EXP 6480464 Mercury results in decreased expression of PIK3R1 mRNA CTD PMID:12730625 metformin increases expression ISO RGD:11103 6480464 Metformin results in increased expression of PIK3R1 mRNA CTD PMID:21870829 metformin multiple interactions ISO RGD:11103 6480464 Metformin inhibits the reaction [Olanzapine results in decreased expression of PIK3R1 mRNA] CTD PMID:32652086 metformin decreases expression EXP 6480464 Metformin results in decreased expression of PIK3R1 mRNA CTD PMID:31324951 methamphetamine increases methylation ISO RGD:11103 6480464 Methamphetamine results in increased methylation of PIK3R1 promoter CTD PMID:26307267 methotrexate affects expression ISO RGD:11103 6480464 Methotrexate affects the expression of PIK3R1 mRNA CTD PMID:18502557 methoxychlor increases methylation EXP 6480464 Methoxychlor results in increased methylation of PIK3R1 gene CTD PMID:23303685 methoxychlor decreases expression EXP 6480464 Methoxychlor results in decreased expression of PIK3R1 mRNA CTD PMID:23303685 methylmercury chloride affects expression EXP 6480464 methylmercuric chloride affects the expression of PIK3R1 mRNA CTD PMID:20864626 mevinphos multiple interactions EXP 6480464 PIK3R1 protein affects the reaction [Mevinphos results in increased activity of RELA protein] CTD PMID:24462917 mevinphos increases phosphorylation EXP 6480464 Mevinphos results in increased phosphorylation of PIK3R1 protein CTD PMID:24462917 mono(2-ethylhexyl) phthalate multiple interactions ISO RGD:731958 6480464 RBP4 protein promotes the reaction [mono-2-ethylhexylphthalate results in decreased phosphorylation of PIK3R1 protein] CTD PMID:31228551 mono(2-ethylhexyl) phthalate decreases phosphorylation ISO RGD:731958 6480464 mono-2-ethylhexylphthalate results in decreased phosphorylation of PIK3R1 protein CTD PMID:31228551 N-acetyl-L-cysteine multiple interactions ISO RGD:731958 6480464 Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [butylphen results in increased abundance of Reactive Oxygen Species]] more ... CTD PMID:28836394 N-methyl-N'-nitro-N-nitrosoguanidine multiple interactions EXP 6480464 geraniol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of PIK3R1 mRNA] CTD PMID:28428697 N-methyl-N'-nitro-N-nitrosoguanidine increases expression EXP 6480464 Methylnitronitrosoguanidine results in increased expression of PIK3R1 mRNA CTD PMID:28428697 N-nitrosodiethylamine increases expression EXP 6480464 Diethylnitrosamine results in increased expression of PIK3R1 mRNA, Diethylnitrosamine results in increased expression of PIK3R1 protein CTD PMID:30423403 , PMID:30779474 N-nitrosodiethylamine multiple interactions EXP 6480464 Hesperidin inhibits the reaction [Diethylnitrosamine results in increased expression of PIK3R1 protein], neferine inhibits the reaction [Diethylnitrosamine results in increased expression of PIK3R1 mRNA] CTD PMID:30423403 , PMID:30779474 naringin multiple interactions ISO RGD:11103 6480464 naringin inhibits the reaction [Dexamethasone results in increased expression of PIK3R1 mRNA] CTD PMID:30878453 nefazodone decreases expression ISO RGD:731958 6480464 nefazodone results in decreased expression of PIK3R1 mRNA CTD PMID:32152650 nefazodone multiple interactions ISO RGD:731958 6480464 [nefazodone co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of PIK3R1 mRNA CTD PMID:32152650 Nonylphenol multiple interactions EXP 6480464 wortmannin inhibits the reaction [nonylphenol results in decreased expression of PIK3R1 protein] CTD PMID:27832966 Nonylphenol decreases expression EXP 6480464 nonylphenol results in decreased expression of PIK3R1 protein CTD PMID:27832966 obeticholic acid decreases expression ISO RGD:731958 6480464 obeticholic acid results in decreased expression of PIK3R1 mRNA CTD PMID:27939613 olanzapine multiple interactions ISO RGD:11103 6480464 capsazepine inhibits the reaction [Olanzapine results in decreased expression of PIK3R1 mRNA] more ... CTD PMID:32652086 olanzapine decreases expression ISO RGD:11103 6480464 Olanzapine results in decreased expression of PIK3R1 mRNA CTD PMID:32652086 paeoniflorin multiple interactions ISO RGD:11103 6480464 peoniflorin promotes the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased phosphorylation of PIK3R1 protein] CTD PMID:29560022 paeoniflorin multiple interactions EXP 6480464 iodopravadoline inhibits the reaction [peoniflorin promotes the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased phosphorylation of PIK3R1 protein]] CTD PMID:29560022 paracetamol decreases expression ISO RGD:731958 6480464 Acetaminophen results in decreased expression of PIK3R1 mRNA CTD PMID:27761495 paraquat increases expression ISO RGD:11103 6480464 Paraquat results in increased expression of PIK3R1 mRNA CTD PMID:12595580 parathion increases methylation ISO RGD:731958 6480464 Parathion results in increased methylation of PIK3R1 promoter CTD PMID:22847954 perfluorooctane-1-sulfonic acid decreases expression ISO RGD:731958 6480464 perfluorooctane sulfonic acid results in decreased expression of PIK3R1 mRNA CTD PMID:27153767 phenformin decreases expression EXP 6480464 Phenformin results in decreased expression of PIK3R1 mRNA CTD PMID:31324951 phenobarbital increases expression EXP 6480464 Phenobarbital results in increased expression of PIK3R1 mRNA CTD PMID:12082028 phenobarbital decreases expression ISO RGD:11103 6480464 Phenobarbital results in decreased expression of PIK3R1 mRNA CTD PMID:23091169 PhIP increases expression EXP 6480464 2-amino-1-methyl-6-phenylimidazo4 more ... CTD PMID:12606953 pirinixic acid multiple interactions ISO RGD:731958 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PIK3R1 mRNA CTD PMID:19710929 pirinixic acid affects expression ISO RGD:11103 6480464 pirinixic acid affects the expression of PIK3R1 mRNA CTD PMID:23811191 pirinixic acid increases expression ISO RGD:11103 6480464 pirinixic acid results in increased expression of PIK3R1 mRNA CTD PMID:18445702 propiconazole decreases expression ISO RGD:11103 6480464 propiconazole results in decreased expression of PIK3R1 mRNA CTD PMID:21278054 quercetin decreases expression ISO RGD:731958 6480464 Quercetin results in decreased expression of PIK3R1 protein modified form CTD PMID:26311153 quercetin decreases phosphorylation ISO RGD:11103 6480464 Quercetin results in decreased phosphorylation of PIK3R1 protein CTD PMID:25658812 quercetin multiple interactions EXP 6480464 Quercetin inhibits the reaction [Oxygen deficiency results in increased expression of PIK3R1 mRNA] CTD PMID:26476374 quercetin 3-O-beta-D-glucofuranoside increases expression ISO RGD:731958 6480464 isoquercitrin results in increased expression of PIK3R1 mRNA CTD PMID:30597948 quercetin 3-O-beta-D-glucopyranoside increases expression ISO RGD:731958 6480464 isoquercitrin results in increased expression of PIK3R1 mRNA CTD PMID:30597948 quercitrin affects expression ISO RGD:731958 6480464 quercitrin affects the expression of PIK3R1 mRNA CTD PMID:25193878 reactive oxygen species multiple interactions ISO RGD:731958 6480464 Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [butylphen results in increased abundance of Reactive Oxygen Species]] more ... CTD PMID:28836394 resveratrol decreases expression ISO RGD:11103 6480464 resveratrol results in decreased expression of PIK3R1 mRNA CTD PMID:22610192 resveratrol increases expression ISO RGD:731958 6480464 resveratrol results in increased expression of PIK3R1 mRNA, resveratrol results in increased expression of PIK3R1 protein CTD PMID:18089832 resveratrol multiple interactions EXP 6480464 resveratrol inhibits the reaction [INS1 protein promotes the reaction [IRS1 protein binds to PIK3R1 protein]], resveratrol inhibits the reaction [Oxygen deficiency results in decreased phosphorylation of PIK3R1 protein] CTD PMID:16626303 , PMID:25352008 resveratrol multiple interactions ISO RGD:731958 6480464 Adenosine Triphosphate inhibits the reaction [resveratrol results in decreased activity of [PIK3R1 protein binds to PIK3CA protein]] more ... CTD PMID:17550345 retinyl acetate increases expression ISO RGD:11103 6480464 retinol acetate results in increased expression of PIK3R1 mRNA CTD PMID:16772331 rivastigmine multiple interactions EXP 6480464 Rivastigmine inhibits the reaction [Streptozocin results in decreased expression of PIK3R1 mRNA] CTD PMID:32805344 rotenone decreases expression EXP 6480464 Rotenone results in decreased expression of PIK3R1 mRNA CTD PMID:28374803 ruthenium red multiple interactions ISO RGD:11103 6480464 Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of PIK3R1 mRNA] CTD PMID:32652086 SB 431542 multiple interactions ISO RGD:731958 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in decreased expression of PIK3R1 mRNA CTD PMID:27188386 selenium atom increases expression ISO RGD:11103 6480464 Selenium results in increased expression of PIK3R1 mRNA CTD PMID:28810182 silicon dioxide decreases expression ISO RGD:11103 6480464 Silicon Dioxide results in decreased expression of PIK3R1 mRNA CTD PMID:19073995 silver atom decreases expression ISO RGD:11103 6480464 Silver results in decreased expression of PIK3R1 mRNA CTD PMID:27131904 silver(0) decreases expression ISO RGD:11103 6480464 Silver results in decreased expression of PIK3R1 mRNA CTD PMID:27131904 sirolimus multiple interactions ISO RGD:731958 6480464 Sirolimus promotes the reaction [IRS1 protein binds to PIK3R1 protein] CTD PMID:17908691 sodium arsenate increases expression ISO RGD:11103 6480464 sodium arsenate results in increased expression of PIK3R1 mRNA CTD PMID:21795629 sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of PIK3R1 mRNA CTD PMID:19072884 sodium arsenite increases expression ISO RGD:11103 6480464 sodium arsenite results in increased expression of PIK3R1 protein CTD PMID:29044176 streptozocin multiple interactions EXP 6480464 Phycocyanin inhibits the reaction [Streptozocin results in decreased expression of PIK3R1 mRNA] more ... CTD PMID:32805344 streptozocin decreases expression EXP 6480464 Streptozocin results in decreased expression of PIK3R1 mRNA CTD PMID:32805344 succimer multiple interactions ISO RGD:11103 6480464 [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of PIK3R1 mRNA CTD PMID:21641980 tamoxifen increases expression ISO RGD:11103 6480464 Tamoxifen results in increased expression of PIK3R1 mRNA CTD PMID:20937368 terbufos increases methylation ISO RGD:731958 6480464 terbufos results in increased methylation of PIK3R1 promoter CTD PMID:22847954 tert-butyl hydroperoxide decreases expression ISO RGD:731958 6480464 tert-Butylhydroperoxide results in decreased expression of PIK3R1 mRNA CTD PMID:15336504 testosterone multiple interactions EXP 6480464 Testosterone inhibits the reaction [Dexamethasone results in increased expression of PIK3R1 mRNA] CTD PMID:20032058 thiazolidinediones increases expression ISO RGD:11103 6480464 Thiazolidinediones results in increased expression of PIK3R1 mRNA CTD PMID:21870829 thioacetamide decreases expression EXP 6480464 Thioacetamide results in decreased expression of PIK3R1 mRNA CTD PMID:23411599 titanium dioxide increases expression ISO RGD:11103 6480464 titanium dioxide results in increased expression of PIK3R1 mRNA CTD PMID:23557971 more ... trans-caffeic acid increases expression ISO RGD:11103 6480464 caffeic acid results in increased expression of PIK3R1 mRNA CTD PMID:21870829 trans-cinnamic acid increases expression ISO RGD:11103 6480464 cinnamic acid results in increased expression of PIK3R1 mRNA CTD PMID:21870829 tremolite asbestos decreases expression ISO RGD:11103 6480464 tremolite results in decreased expression of PIK3R1 mRNA CTD PMID:29279043 trichostatin A decreases expression ISO RGD:731958 6480464 trichostatin A results in decreased expression of PIK3R1 mRNA CTD PMID:24935251 triptonide decreases expression ISO RGD:11103 6480464 triptonide results in decreased expression of PIK3R1 mRNA CTD PMID:33045310 tris(2-butoxyethyl) phosphate affects expression ISO RGD:731958 6480464 tris2-butoxyethyl phosphate affects the expression of PIK3R1 mRNA CTD PMID:29024780 tungsten decreases expression ISO RGD:11103 6480464 Tungsten results in decreased expression of PIK3R1 mRNA CTD PMID:30912803 tunicamycin decreases expression ISO RGD:11103 6480464 Tunicamycin results in decreased expression of PIK3R1 mRNA CTD PMID:17127020 uranium atom affects expression ISO RGD:731958 6480464 Uranium affects the expression of PIK3R1 mRNA CTD PMID:15672453 urethane increases expression ISO RGD:731958 6480464 Urethane results in increased expression of PIK3R1 mRNA CTD PMID:28818685 valproic acid affects expression ISO RGD:11103 6480464 Valproic Acid affects the expression of PIK3R1 mRNA CTD PMID:17292431 valproic acid increases expression ISO RGD:731958 6480464 Valproic Acid results in increased expression of PIK3R1 mRNA CTD PMID:24935251 vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of PIK3R1 mRNA CTD PMID:23034163 vitamin E decreases expression ISO RGD:731958 6480464 Vitamin E results in decreased expression of PIK3R1 mRNA CTD PMID:19244175 wortmannin decreases activity ISO RGD:731958 6480464 wortmannin results in decreased activity of PIK3R1 protein CTD PMID:19036708 wortmannin multiple interactions EXP 6480464 Wortmannin inhibits the reaction [nonylphenol results in decreased expression of PIK3R1 protein], Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in decreased expression of PIK3R1 mRNA]] CTD PMID:27832966 , PMID:32805344 zoledronic acid increases expression ISO RGD:731958 6480464 zoledronic acid results in increased expression of PIK3R1 mRNA CTD PMID:24714768