Pik3r1 (phosphoinositide-3-kinase regulatory subunit 1) - Rat Genome Database

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Gene: Pik3r1 (phosphoinositide-3-kinase regulatory subunit 1) Rattus norvegicus
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Symbol: Pik3r1
Name: phosphoinositide-3-kinase regulatory subunit 1
RGD ID: 3329
Description: Exhibits several functions, including 1-phosphatidylinositol-3-kinase regulator activity; enzyme binding activity; and signaling receptor binding activity. Contributes to 1-phosphatidylinositol-3-kinase activity. Involved in several processes, including regulation of phosphorylation; response to steroid hormone; and transmembrane receptor protein tyrosine kinase signaling pathway. Localizes to several cellular components, including neuron projection; nucleus; and phosphatidylinositol 3-kinase complex. Used to study hypertension and portal hypertension. Biomarker of hypertension; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including SHORT syndrome; astroblastoma; endometrial cancer (multiple); immunodeficiency 36; and type 2 diabetes mellitus. Orthologous to human PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1); PARTICIPATES IN insulin signaling pathway; E-cadherin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; phosphatidylinositol 3-kinase p85 alpha; phosphatidylinositol 3-kinase regulatory subunit alpha; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); phosphoinositide 3-kinase p85; Phosphoinositide 3-kinase p85 (other splicing variants: p55 and p50); Phosphoinositide 3-kinase regulatory subunit polypeptide 1 (p85 alpha); Phosphoinositide 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); phosphoinositide-3-kinase, regulatory subunit 1 (alpha); PI3-kinase p85 subunit alpha; PI3-kinase regulatory subunit alpha; PI3-kinase subunit p85-alpha; PI3K regulatory subunit alpha; PI3KA; ptdIns-3-kinase p85-alpha; ptdIns-3-kinase regulatory subunit alpha; ptdIns-3-kinase regulatory subunit p85-alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2232,878,942 - 32,963,611 (-)NCBI
Rnor_6.0 Ensembl231,745,088 - 31,826,867 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0231,742,326 - 31,826,882 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0250,891,225 - 50,965,217 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4232,602,673 - 32,675,350 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1232,523,041 - 32,595,719 (-)NCBI
Celera228,878,690 - 28,948,863 (-)NCBICelera
RH 3.4 Map2111.0RGD
Cytogenetic Map2q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-tert-butylphenol  (ISO)
9-cis-retinoic acid  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
anthocyanin  (EXP)
arecoline  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atazanavir sulfate  (ISO)
ATP  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bexarotene  (ISO)
bilirubin IXalpha  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bromobenzene  (EXP)
cadmium atom  (ISO)
cantharidin  (ISO)
capsaicin  (ISO)
capsazepine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
celastrol  (ISO)
chenodeoxycholic acid  (ISO)
chlorogenic acid  (ISO)
chromium atom  (ISO)
ciguatoxin CTX1B  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
cobalt dichloride  (ISO)
coenzyme Q10  (EXP)
conjugated linoleic acid  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
daunorubicin  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
diallyl trisulfide  (EXP)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
diclofenac  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
emodin  (EXP)
endosulfan  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
eugenol  (EXP,ISO)
ferulic acid  (ISO)
folic acid  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
fructose  (EXP)
furan  (EXP)
Garcinol  (ISO)
gedunin  (ISO)
geldanamycin  (ISO)
geraniol  (EXP)
glucose  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hesperidin  (EXP)
HU-308  (EXP)
hydrazines  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
iron(2+) sulfate (anhydrous)  (EXP)
isoprenaline  (ISO)
L-ascorbic acid  (EXP)
lead diacetate  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
linsidomine  (ISO)
LY294002  (ISO)
melphalan  (ISO)
mercury atom  (EXP)
mercury(0)  (EXP)
metformin  (EXP,ISO)
methamphetamine  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (EXP)
mevinphos  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (EXP)
naringin  (ISO)
nefazodone  (ISO)
Nonylphenol  (EXP)
obeticholic acid  (ISO)
olanzapine  (ISO)
paeoniflorin  (EXP,ISO)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
PhIP  (EXP)
pirinixic acid  (ISO)
propiconazole  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
quercitrin  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
retinyl acetate  (ISO)
rivastigmine  (EXP)
rotenone  (EXP)
ruthenium red  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
streptozocin  (EXP)
succimer  (ISO)
tamoxifen  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
thiazolidinediones  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trans-caffeic acid  (ISO)
trans-cinnamic acid  (ISO)
tremolite asbestos  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
uranium atom  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
wortmannin  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (IEP)
B cell differentiation  (IEA,ISO)
cellular glucose homeostasis  (IEA,ISO,ISS)
cellular response to fatty acid  (IEP)
cellular response to insulin stimulus  (IEP,ISO,ISS)
cellular response to UV  (IEA,ISO)
extrinsic apoptotic signaling pathway via death domain receptors  (IEA,ISO)
glucose metabolic process  (IMP)
growth hormone receptor signaling pathway  (IEA,ISO)
insulin receptor signaling pathway  (IBA,IEA,IMP,ISO,ISS)
insulin-like growth factor receptor signaling pathway  (IEA,IMP,ISO,ISS)
intrinsic apoptotic signaling pathway in response to DNA damage  (IEA,ISO)
negative regulation of apoptotic process  (IEA,ISO,ISS)
negative regulation of blood pressure  (IMP)
negative regulation of cell adhesion  (ISO)
negative regulation of cell-cell adhesion  (IMP)
negative regulation of cell-matrix adhesion  (IEA,ISO)
negative regulation of heart rate  (IMP)
negative regulation of muscle cell apoptotic process  (IMP)
negative regulation of osteoclast differentiation  (IEA,ISO)
negative regulation of proteolysis  (IMP)
negative regulation of smooth muscle cell proliferation  (IMP)
negative regulation of stress fiber assembly  (IEA,ISO)
phosphatidylinositol 3-kinase signaling  (IEA,ISO)
phosphatidylinositol phosphate biosynthetic process  (IBA,ISS)
phosphatidylinositol-3-phosphate biosynthetic process  (IEA)
positive regulation of cell migration  (IEA,IMP,ISO)
positive regulation of endoplasmic reticulum unfolded protein response  (IEA,ISO,ISS)
positive regulation of filopodium assembly  (IEA,ISO)
positive regulation of focal adhesion disassembly  (IEA,ISO)
positive regulation of gene expression  (IMP)
positive regulation of lamellipodium assembly  (IEA,ISO)
positive regulation of myoblast differentiation  (IMP)
positive regulation of protein import into nucleus  (IEA,ISO,ISS)
positive regulation of protein phosphorylation  (IMP)
positive regulation of RNA splicing  (IEA,ISO,ISS)
positive regulation of synapse assembly  (IDA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO,ISS)
positive regulation of tumor necrosis factor production  (IEA,ISO)
protein import into nucleus  (IEA,ISO)
protein phosphorylation  (IEA,ISO)
protein stabilization  (IEA,ISO,ISS)
regulation of insulin receptor signaling pathway  (IEA,ISO)
regulation of phosphatidylinositol 3-kinase activity  (IBA,IDA)
regulation of protein localization to plasma membrane  (IEA,ISO)
regulation of stress fiber assembly  (ISO)
response to amino acid  (IEP)
response to cAMP  (IDA)
response to dexamethasone  (IEP)
response to drug  (IEP)
response to endoplasmic reticulum stress  (IEA,ISO,ISS)
response to estradiol  (IEP)
response to ethanol  (IEP)
response to fatty acid  (IEP)
response to fructose  (IEP)
response to glucocorticoid  (IDA)
response to growth factor  (IEP)
response to insulin  (IDA)
response to iron(II) ion  (IEP)
response to nutrient  (IEP)
response to progesterone  (IEP)
response to testosterone  (IEP)
response to yeast  (IEP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acute myeloid leukemia pathway  (IEA)
aldosterone signaling pathway  (IEA)
apoptotic cell death pathway  (IEA)
B cell receptor signaling pathway  (IEA)
ceramide signaling pathway  (IEA)
Chagas disease pathway  (IEA)
chemokine mediated signaling pathway  (IEA)
chronic myeloid leukemia pathway  (IEA)
colorectal cancer pathway  (IEA)
E-cadherin signaling pathway  (ISO)
endometrial cancer pathway  (IEA)
Entamoebiasis pathway  (IEA)
ephrin - ephrin receptor bidirectional signaling axis  (ISO)
epidermal growth factor/neuregulin signaling pathway  (IEA,ISO)
erythropoietin signaling pathway  (ISO)
FasL mediated signaling pathway  (ISO)
Fc epsilon receptor mediated signaling pathway  (IEA,ISO)
Fc gamma receptor mediated signaling pathway  (IEA)
fibroblast growth factor signaling pathway  (ISO)
glioma pathway  (IEA)
granulocyte-macrophage colony-stimulating factor signaling pathway  (ISO)
Hedgehog signaling pathway  (ISO)
hepatitis C pathway  (IEA)
influenza A pathway  (IEA)
insulin signaling pathway  (IDA,IEA,ISO)
insulin-like growth factor signaling pathway  (ISO)
interleukin-1 signaling pathway  (ISO)
interleukin-2 signaling pathway  (ISO)
interleukin-23 signaling pathway  (ISO)
interleukin-3 signaling pathway  (ISO)
interleukin-4 signaling pathway  (ISO)
interleukin-5 signaling pathway  (ISO)
interleukin-6 signaling pathway  (ISO)
Jak-Stat signaling pathway  (IEA)
measles pathway  (IEA)
melanoma pathway  (IEA)
mTOR signaling pathway  (IEA)
N-cadherin signaling pathway  (ISO)
neurotrophic factor signaling pathway  (IEA)
non-small cell lung carcinoma pathway  (IEA)
nuclear factor kappa B signaling pathway  (ISO)
pancreatic cancer pathway  (IEA)
phosphatidylinositol 3-kinase class I signaling pathway  (ISO)
phosphatidylinositol 3-kinase signaling pathway  (IEA)
phosphatidylinositol 3-kinase-Akt signaling pathway  (ISO)
phosphoinositide metabolic pathway  (ISO)
platelet-derived growth factor signaling pathway  (ISO)
prostate cancer pathway  (IEA)
Reelin signaling pathway  (ISO)
renal cell carcinoma pathway  (IEA)
scatter factor/hepatocyte growth factor signaling pathway  (ISO)
small cell lung carcinoma pathway  (IEA)
T cell receptor signaling pathway  (IEA)
Toll-like receptor signaling pathway  (IEA)
toxoplasmosis pathway  (IEA)
Trail mediated signaling pathway  (ISO)
type 2 diabetes mellitus pathway  (IEA)
type II interferon signaling pathway  (ISO)
vascular endothelial growth factor signaling pathway  (IEA,ISO)

References

References - curated
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Additional References at PubMed
PMID:7537849   PMID:7539611   PMID:7541045   PMID:7782332   PMID:8183574   PMID:8402898   PMID:8440175   PMID:8550620   PMID:8628286   PMID:8781294   PMID:9415395   PMID:9748281  
PMID:9791008   PMID:10572067   PMID:10860857   PMID:12408866   PMID:12594288   PMID:12960006   PMID:14699157   PMID:15039234   PMID:15192701   PMID:15488758   PMID:15845362   PMID:15858065  
PMID:16043515   PMID:16569213   PMID:16717100   PMID:16960657   PMID:17053831   PMID:17242187   PMID:18417706   PMID:18828053   PMID:19298529   PMID:19689064   PMID:19946888   PMID:20042608  
PMID:20348923   PMID:20348926   PMID:20624904   PMID:20669351   PMID:21321938   PMID:21671003   PMID:21704119   PMID:21788123   PMID:22341695   PMID:23793062   PMID:24057979   PMID:24090963  
PMID:24907397   PMID:25048263   PMID:25217619   PMID:25667086   PMID:26657864  


Genomics

Candidate Gene Status
Pik3r1 is a candidate Gene for QTL Bp115
Comparative Map Data
Pik3r1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2232,878,942 - 32,963,611 (-)NCBI
Rnor_6.0 Ensembl231,745,088 - 31,826,867 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0231,742,326 - 31,826,882 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0250,891,225 - 50,965,217 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4232,602,673 - 32,675,350 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1232,523,041 - 32,595,719 (-)NCBI
Celera228,878,690 - 28,948,863 (-)NCBICelera
RH 3.4 Map2111.0RGD
Cytogenetic Map2q12NCBI
PIK3R1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl568,215,756 - 68,301,821 (+)EnsemblGRCh38hg38GRCh38
GRCh38568,215,737 - 68,301,821 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37567,511,584 - 67,597,649 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36567,558,218 - 67,633,405 (+)NCBINCBI36hg18NCBI36
Build 34567,622,250 - 67,633,403NCBI
Celera564,520,829 - 64,597,175 (+)NCBI
Cytogenetic Map5q13.1NCBI
HuRef564,468,818 - 64,555,164 (+)NCBIHuRef
CHM1_1567,511,846 - 67,597,747 (+)NCBICHM1_1
Pik3r1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913101,817,269 - 101,904,725 (-)NCBIGRCm39mm39
GRCm39 Ensembl13101,817,071 - 101,904,725 (-)Ensembl
GRCm3813101,680,761 - 101,768,217 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13101,680,563 - 101,768,217 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713102,450,716 - 102,538,172 (-)NCBIGRCm37mm9NCBIm37
MGSCv3613102,781,018 - 102,792,904 (-)NCBImm8
Celera13105,285,857 - 105,373,612 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1353.92NCBI
Pik3r1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554461,020,043 - 1,098,820 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554461,020,707 - 1,098,327 (-)NCBIChiLan1.0ChiLan1.0
PIK3R1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1547,268,477 - 47,350,960 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl547,267,286 - 47,350,960 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0545,701,219 - 45,786,652 (-)NCBIMhudiblu_PPA_v0panPan3
PIK3R1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1253,447,802 - 53,527,563 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl253,448,286 - 53,524,970 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha250,408,936 - 50,489,628 (+)NCBI
ROS_Cfam_1.0253,951,256 - 54,032,010 (+)NCBI
UMICH_Zoey_3.1251,011,708 - 51,092,420 (+)NCBI
UNSW_CanFamBas_1.0251,791,194 - 51,871,863 (+)NCBI
UU_Cfam_GSD_1.0252,678,736 - 52,759,442 (+)NCBI
Pik3r1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213192,252,011 - 192,336,736 (-)NCBI
SpeTri2.0NW_0049364801,188,408 - 1,273,210 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIK3R1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1646,434,873 - 46,523,609 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11646,434,757 - 46,523,626 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21650,135,837 - 50,148,434 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PIK3R1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1464,321,296 - 64,406,188 (+)NCBI
ChlSab1.1 Ensembl464,321,078 - 64,406,519 (+)Ensembl
Pik3r1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248151,290,106 - 1,376,961 (-)NCBI

Position Markers
U50413  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0231,746,164 - 31,746,247NCBIRnor6.0
Rnor_5.0250,895,063 - 50,895,146UniSTSRnor5.0
RGSC_v3.4232,602,472 - 32,602,555UniSTSRGSC3.4
Celera228,878,489 - 28,878,572UniSTS
Cytogenetic Map2q12UniSTS
RH94812  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0231,748,473 - 31,748,733NCBIRnor6.0
Rnor_5.0250,897,372 - 50,897,632UniSTSRnor5.0
RGSC_v3.4232,604,781 - 32,605,041UniSTSRGSC3.4
Celera228,880,798 - 28,881,058UniSTS
RH 3.4 Map2111.0UniSTS
Cytogenetic Map2q12UniSTS
BF390857  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0231,801,324 - 31,801,490NCBIRnor6.0
Rnor_5.0250,950,223 - 50,950,389UniSTSRnor5.0
RGSC_v3.4232,660,025 - 32,660,191UniSTSRGSC3.4
Celera228,933,723 - 28,933,889UniSTS
RH 3.4 Map2111.7UniSTS
Cytogenetic Map2q12UniSTS
Pik3r1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0231,746,157 - 31,746,340NCBIRnor6.0
Rnor_5.0250,895,056 - 50,895,239UniSTSRnor5.0
RGSC_v3.4232,602,465 - 32,602,648UniSTSRGSC3.4
Celera228,878,482 - 28,878,665UniSTS
Cytogenetic Map2q12UniSTS
RH138083  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0231,796,258 - 31,796,410NCBIRnor6.0
Rnor_5.0250,945,157 - 50,945,309UniSTSRnor5.0
RGSC_v3.4232,654,435 - 32,654,587UniSTSRGSC3.4
Celera228,928,588 - 28,928,740UniSTS
RH 3.4 Map279.0UniSTS
Cytogenetic Map2q12UniSTS
RH138178  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0231,799,867 - 31,799,986NCBIRnor6.0
Rnor_5.0250,948,766 - 50,948,885UniSTSRnor5.0
RGSC_v3.4232,658,584 - 32,658,703UniSTSRGSC3.4
RGSC_v3.4232,658,044 - 32,658,163UniSTSRGSC3.4
Celera228,932,197 - 28,932,316UniSTS
RH 3.4 Map2111.4UniSTS
Cytogenetic Map2q12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135167060Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141179397Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)23127638105149020Rat
9590080Insglur4Insulin/glucose ratio QTL 428.70.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)2368630848686308Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2541733642777046Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2789360052893600Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)2944467949615930Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)2944467968866454Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21055527555555275Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21423783059237830Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)216679272245624402Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21901646564016465Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22027698165276981Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22064137165641371Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22261295267612952Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22328064775687607Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)223837491149614623Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)223837491169852800Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)223837491169852800Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)223837491169852800Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)223837491169852800Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)223837491169852800Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)223837491169852800Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)223837491218957222Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)223837491218957222Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)223837719169852670Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)223837719169852670Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22618609783819822Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22618609783819822Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)22618609783819822Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226186097135654963Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226186097142053534Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22626799543133606Rat
1643006Pain1Pain QTL 13.630.005mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)22626799548676716Rat
12879841Cm87Cardiac mass QTL 870.026heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)227161361148295267Rat
12879842Cm88Cardiac mass QTL 880.042heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)227161361148295267Rat
12879843Am3Aortic mass QTL 30.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)227161361148295267Rat
12879844Kidm62Kidney mass QTL 620.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227161361148295267Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22776030172760301Rat
1300160Hrtrt3Heart rate QTL 33.62heart pumping trait (VT:2000009)absolute change in heart rate (CMO:0000534)22872786752507805Rat
731179Mamtr3Mammary tumor resistance QTL 30.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)23122461243643900Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23127237976272379Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:273
Count of miRNA genes:99
Interacting mature miRNAs:113
Transcripts:ENSRNOT00000025687, ENSRNOT00000065301, ENSRNOT00000075057
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 34 53 37 19 37 8 9 74 35 34 11 8
Low 9 4 4 4 2 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000025687   ⟹   ENSRNOP00000025687
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl231,745,088 - 31,826,867 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000075057   ⟹   ENSRNOP00000067155
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl231,746,365 - 31,753,528 (-)Ensembl
RefSeq Acc Id: NM_013005   ⟹   NP_037137
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2232,882,983 - 32,953,207 (-)NCBI
Rnor_6.0231,746,365 - 31,816,385 (-)NCBI
Rnor_5.0250,891,225 - 50,965,217 (-)NCBI
RGSC_v3.4232,602,673 - 32,675,350 (-)RGD
Celera228,878,690 - 28,948,863 (-)RGD
Sequence:
RefSeq Acc Id: XM_006231868   ⟹   XP_006231930
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2232,882,983 - 32,891,084 (-)NCBI
Rnor_6.0231,742,326 - 31,754,521 (-)NCBI
Rnor_5.0250,891,225 - 50,965,217 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008760659   ⟹   XP_008758881
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2232,878,942 - 32,894,171 (-)NCBI
Rnor_6.0231,742,326 - 31,758,165 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017590649   ⟹   XP_017446138
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2232,878,942 - 32,963,611 (-)NCBI
Rnor_6.0231,742,326 - 31,826,882 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_037137   ⟸   NM_013005
- UniProtKB: Q63787 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006231930   ⟸   XM_006231868
- Peptide Label: isoform X2
- UniProtKB: M0RC47 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008758881   ⟸   XM_008760659
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017446138   ⟸   XM_017590649
- Peptide Label: isoform X1
- UniProtKB: F1LNG5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000067155   ⟸   ENSRNOT00000075057
RefSeq Acc Id: ENSRNOP00000025687   ⟸   ENSRNOT00000025687
Protein Domains
Rho-GAP   SH2   SH3

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691115
Promoter ID:EPDNEW_R1640
Type:initiation region
Name:Pik3r1_1
Description:phosphoinositide-3-kinase regulatory subunit 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0231,826,844 - 31,826,904EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3329 AgrOrtholog
Ensembl Genes ENSRNOG00000018903 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000025687 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000067155 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025687 UniProtKB/TrEMBL
  ENSRNOT00000075057 UniProtKB/TrEMBL
Gene3D-CATH 1.10.555.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ISH2_PIK3R1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_P85_iSH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_p85alpha_SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3kinase_P85_cSH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3kinase_P85_nSH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGAP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25513 UniProtKB/Swiss-Prot
NCBI Gene 25513 ENTREZGENE
Pfam PI3K_P85_iSH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_2 UniProtKB/TrEMBL
PhenoGen Pik3r1 PhenoGen
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RHOGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RhoGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC228818
UniProt F1LNG5 ENTREZGENE, UniProtKB/TrEMBL
  M0RC47 ENTREZGENE, UniProtKB/TrEMBL
  P85A_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  V5LVG2_RAT UniProtKB/TrEMBL
UniProt Secondary O55085 UniProtKB/Swiss-Prot
  P70544 UniProtKB/Swiss-Prot
  Q63790 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-30 Pik3r1  phosphoinositide-3-kinase regulatory subunit 1  Pik3r1  phosphoinositide-3-kinase, regulatory subunit 1 (alpha)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 Pik3r1  phosphoinositide-3-kinase, regulatory subunit 1 (alpha)  Pik3r1  phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-14 Pik3r1  phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)  Pik3r1  phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2001-05-08 Pik3r1  Phosphoinositide 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)      Name changed to reflect Human and Mouse nomenclature 62408 APPROVED
2001-05-08 Pik3r1  Phosphoinositide 3-kinase p85      Name withdrawn, does not match Human and Mouse nomenclature 62408 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_domains contains SH2 domains 729673
gene_expression expressed in hepatic, brain and renal tissues 729673
gene_function activation is strongly induced by insulin 729673
gene_function activation is required for insulin-stimulated glucose transport and insulin-dependent p70S6K activation 68289
gene_function phosphorylates a variety of lipids and proteins to activate specific signaling cascades 729503
gene_homology alternative splice product of 55 kDa, p55alpha, has homology to p55 gamma (Pik3r3) 68289
gene_physical_interaction tyrosine kinase receptor binding 729673
gene_physical_interaction binds to and is stimulated by phosphorylated substrates 729673
gene_physical_interaction binds to insulin receptor 729673
gene_physical_interaction forms a heterodimer with the p110 catalytic subunit 729673
gene_regulation regulatory subunit of holoprotein p85 729673
gene_transcript three splice variants, p85, p55 and p50 68289