1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine increases expression EXP 6480464 chlorcyclizine results in increased expression of PIK3R1 mRNA CTD PMID:21058326 17beta-estradiol decreases expression EXP 6480464 Estradiol results in decreased expression of PIK3R1 protein CTD PMID:22142692 17beta-estradiol decreases expression ISO RGD:11103 6480464 Estradiol results in decreased expression of PIK3R1 mRNA CTD PMID:25210133 17beta-estradiol multiple interactions ISO RGD:11103 6480464 ESR1 protein promotes the reaction [Estradiol results in decreased expression of PIK3R1 mRNA] CTD PMID:25210133 17beta-estradiol 3-benzoate increases methylation EXP 6480464 estradiol 3-benzoate results in increased methylation of PIK3R1 promoter CTD PMID:27415467 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:11103 6480464 [Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of PIK3R1 mRNA CTD PMID:28433925 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:731958 6480464 Tetrachlorodibenzodioxin results in increased expression of PIK3R1 mRNA CTD PMID:17101203 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:11103 6480464 Tetrachlorodibenzodioxin results in decreased expression of PIK3R1 mRNA CTD PMID:19770486 PMID:22666406 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:11103 6480464 Tetrachlorodibenzodioxin affects the expression of PIK3R1 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:731958 6480464 Tetrachlorodibenzodioxin affects the expression of PIK3R1 mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of PIK3R1 mRNA CTD PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 AHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of PIK3R1 mRNA] CTD PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:11103 6480464 [Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of PIK3R1 mRNA; more ... CTD PMID:19654925 PMID:28433925 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:11103 6480464 Tetrachlorodibenzodioxin results in increased expression of PIK3R1 mRNA CTD PMID:18691609 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:731958 6480464 Tetrachlorodibenzodioxin results in decreased expression of PIK3R1 mRNA CTD PMID:20106945 2-butoxyethanol increases expression ISO RGD:11103 6480464 n-butoxyethanol results in increased expression of PIK3R1 mRNA CTD PMID:19812364 3,3',4,4',5-pentachlorobiphenyl decreases expression EXP 6480464 3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of PIK3R1 mRNA CTD PMID:23196670 3,3',4,4'-tetrachlorobiphenyl multiple interactions ISO RGD:11103 6480464 3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of PIK3R1 mRNA] CTD PMID:19467301 3-chloropropane-1,2-diol increases expression EXP 6480464 alpha-Chlorohydrin results in increased expression of PIK3R1 mRNA CTD PMID:28522335 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:731958 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PIK3R1 mRNA; more ... CTD PMID:28628672 3-methylcholanthrene multiple interactions ISO RGD:731958 6480464 Methylcholanthrene promotes the reaction [AHR protein binds to PIK3R1 promoter] CTD PMID:20348232 3H-1,2-dithiole-3-thione decreases expression EXP 6480464 1,2-dithiol-3-thione results in decreased expression of PIK3R1 mRNA CTD PMID:19162173 4-hydroxyphenyl retinamide decreases expression ISO RGD:11103 6480464 Fenretinide results in decreased expression of PIK3R1 mRNA CTD PMID:28973697 4-tert-butylphenol multiple interactions ISO RGD:731958 6480464 Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [butylphen results in increased abundance of Reactive Oxygen Species]]; more ... CTD PMID:28836394 acetylsalicylic acid decreases expression ISO RGD:731958 6480464 Aspirin results in decreased expression of PIK3R1 mRNA CTD PMID:20457246 acrylamide increases expression EXP 6480464 Acrylamide results in increased expression of PIK3R1 mRNA CTD PMID:22197712 aflatoxin B1 increases expression ISO RGD:11103 6480464 Aflatoxin B1 results in increased expression of PIK3R1 mRNA CTD PMID:19770486 aflatoxin B1 decreases methylation ISO RGD:731958 6480464 Aflatoxin B1 results in decreased methylation of PIK3R1 gene CTD PMID:27153756 aflatoxin B1 decreases expression ISO RGD:731958 6480464 Aflatoxin B1 results in decreased expression of PIK3R1 mRNA CTD PMID:27153756 aldehydo-D-glucose multiple interactions ISO RGD:731958 6480464 Glucose promotes the reaction [PIK3R1 protein binds to IRS1 protein] CTD PMID:10430617 all-trans-retinoic acid multiple interactions ISO RGD:11103 6480464 PIK3R1 protein promotes the reaction [Tretinoin results in increased activity of AKT1 protein] CTD PMID:16288212 all-trans-retinoic acid increases expression ISO RGD:731958 6480464 Tretinoin results in increased expression of PIK3R1 mRNA CTD PMID:23830798 all-trans-retinoic acid increases expression ISO RGD:11103 6480464 Tretinoin results in increased expression of PIK3R1 mRNA; more ... CTD PMID:16288212 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of PIK3R1 mRNA CTD PMID:16483693 anthocyanin increases expression EXP 6480464 Anthocyanins results in increased expression of PIK3R1 mRNA CTD PMID:18803703 arecoline increases expression EXP 6480464 Arecoline results in increased expression of PIK3R1 mRNA CTD PMID:20724125 arsane decreases expression ISO RGD:731958 6480464 Arsenic results in decreased expression of PIK3R1 mRNA CTD PMID:19945496 arsenic atom decreases expression ISO RGD:731958 6480464 Arsenic results in decreased expression of PIK3R1 mRNA CTD PMID:19945496 arsenic(3+) decreases expression ISO RGD:731958 6480464 Arsenic results in decreased expression of PIK3R1 mRNA CTD PMID:19945496 arsenite(3-) multiple interactions ISO RGD:11103 6480464 arsenite promotes the reaction [PIK3R1 protein results in increased expression of HIF1A mRNA]; more ... CTD PMID:20835880 ATP multiple interactions ISO RGD:731958 6480464 Adenosine Triphosphate inhibits the reaction [resveratrol results in decreased activity of [PIK3R1 protein binds to PIK3CA protein]] CTD PMID:17550345 atrazine decreases expression ISO RGD:731958 6480464 Atrazine results in decreased expression of PIK3R1 mRNA CTD PMID:22378314 benzo[a]pyrene multiple interactions ISO RGD:11103 6480464 Benzo(a)pyrene promotes the reaction [AHR protein binds to PIK3R1 promoter] CTD PMID:19654925 benzo[a]pyrene increases expression ISO RGD:11103 6480464 Benzo(a)pyrene results in increased expression of PIK3R1 mRNA CTD PMID:23735875 benzo[a]pyrene decreases expression ISO RGD:11103 6480464 Benzo(a)pyrene results in decreased expression of PIK3R1 mRNA CTD PMID:19770486 PMID:22228805 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:731958 6480464 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PIK3R1 mRNA CTD PMID:28529061 bexarotene multiple interactions ISO RGD:731958 6480464 bexarotene promotes the reaction [rosiglitazone results in increased expression of PIK3R1 mRNA] CTD PMID:10548525 bilirubin IXalpha decreases expression ISO RGD:731958 6480464 Bilirubin results in decreased expression of PIK3R1 mRNA CTD PMID:20196124 bis(2-chloroethyl) sulfide decreases expression ISO RGD:11103 6480464 Mustard Gas results in decreased expression of PIK3R1 mRNA CTD PMID:18955075 bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:11103 6480464 [Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of PIK3R1 mRNA CTD PMID:28433925 bisphenol A increases expression ISO RGD:731958 6480464 bisphenol A results in increased expression of PIK3R1 mRNA CTD PMID:21890461 bisphenol A multiple interactions ISO RGD:11103 6480464 [Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of PIK3R1 mRNA CTD PMID:28433925 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of PIK3R1 gene CTD PMID:28505145 bisphenol A multiple interactions ISO RGD:731958 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PIK3R1 mRNA CTD PMID:28628672 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of PIK3R1 mRNA CTD PMID:25181051 bisphenol A increases expression ISO RGD:11103 6480464 bisphenol A results in increased expression of PIK3R1 mRNA CTD PMID:25594700 PMID:26063408 bisphenol A decreases expression ISO RGD:731958 6480464 bisphenol A results in decreased expression of PIK3R1 mRNA CTD PMID:22576693 bisphenol A increases methylation ISO RGD:731958 6480464 bisphenol A results in increased methylation of PIK3R1 gene CTD PMID:22576693 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of PIK3R1 protein CTD PMID:22142692 Bisphenol A diglycidyl ether multiple interactions ISO RGD:731958 6480464 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [1-(methylimino-N-oxy)-6-(2-morpholinoethoxy)-3-phenyl-1H-indene-2-carboxylic acid ethyl ester inhibits the reaction [VEGFA protein results in increased phosphorylation of PIK3R1 protein]] CTD PMID:21769449 cadmium atom decreases expression ISO RGD:11103 6480464 Cadmium results in decreased expression of PIK3R1 mRNA CTD PMID:22666406 capsaicin multiple interactions ISO RGD:11103 6480464 PIK3R1 gene mutant form inhibits the reaction [NGF protein results in increased susceptibility to Capsaicin] CTD PMID:17324588 carbamazepine affects expression ISO RGD:731958 6480464 Carbamazepine affects the expression of PIK3R1 mRNA CTD PMID:24752500 carbon nanotube decreases expression ISO RGD:11103 6480464 Nanotubes, Carbon analog results in decreased expression of PIK3R1 mRNA CTD PMID:21624382 celastrol decreases expression ISO RGD:731958 6480464 tripterine results in decreased expression of PIK3R1 mRNA CTD PMID:17010675 chlorogenic acid increases expression ISO RGD:11103 6480464 Chlorogenic Acid results in increased expression of PIK3R1 mRNA CTD PMID:21870829 chromium atom multiple interactions ISO RGD:11103 6480464 Chromium inhibits the reaction [Dietary Fats results in decreased expression of PIK3R1 protein] CTD PMID:20513351 chromium(3+) multiple interactions ISO RGD:11103 6480464 Chromium inhibits the reaction [Dietary Fats results in decreased expression of PIK3R1 protein] CTD PMID:20513351 ciguatoxin CTX1B affects expression ISO RGD:11103 6480464 Ciguatoxins affects the expression of PIK3R1 mRNA CTD PMID:18353800 cinnamic acid increases expression ISO RGD:11103 6480464 cinnamic acid results in increased expression of PIK3R1 mRNA CTD PMID:21870829 cis-caffeic acid increases expression ISO RGD:11103 6480464 caffeic acid results in increased expression of PIK3R1 mRNA CTD PMID:21870829 cisplatin decreases response to substance ISO RGD:731958 6480464 PIK3R1 results in decreased susceptibility to Cisplatin CTD PMID:21571862 cobalt dichloride decreases expression ISO RGD:731958 6480464 cobaltous chloride results in decreased expression of PIK3R1 mRNA CTD PMID:19320972 coenzyme Q10 multiple interactions EXP 6480464 coenzyme Q10 inhibits the reaction [APP protein results in decreased expression of PIK3R1 protein] CTD PMID:22186599 conjugated linoleic acid decreases expression ISO RGD:731958 6480464 Linoleic Acids, Conjugated results in decreased expression of PIK3R1 protein CTD PMID:19800873 cyclosporin A decreases expression ISO RGD:11103 6480464 Cyclosporine results in decreased expression of PIK3R1 mRNA CTD PMID:19770486 PMID:23830897 cyclosporin A decreases expression ISO RGD:731958 6480464 Cyclosporine results in decreased expression of PIK3R1 mRNA CTD PMID:20106945 more ... D-glucose multiple interactions ISO RGD:731958 6480464 Glucose promotes the reaction [PIK3R1 protein binds to IRS1 protein] CTD PMID:10430617 daunorubicin affects response to substance ISO RGD:731958 6480464 PIK3R1 affects the susceptibility to Daunorubicin CTD PMID:17545624 dexamethasone increases expression ISO RGD:731958 6480464 Dexamethasone results in increased expression of PIK3R1 mRNA; more ... CTD PMID:15576458 PMID:25047013 dexamethasone multiple interactions ISO RGD:731958 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PIK3R1 mRNA; more ... CTD PMID:28628672 dexamethasone affects response to substance ISO RGD:11103 6480464 PIK3R1 protein affects the susceptibility to Dexamethasone CTD PMID:22733784 dexamethasone multiple interactions ISO RGD:11103 6480464 PIK3R1 mutant form inhibits the reaction [Dexamethasone results in decreased expression of and results in increased phosphorylation of IRS1 protein]; more ... CTD PMID:22733784 PMID:28292967 dexamethasone increases expression ISO RGD:11103 6480464 Dexamethasone results in increased expression of PIK3R1; more ... CTD PMID:22733784 PMID:28292967 dexamethasone increases expression EXP 6480464 Dexamethasone results in increased expression of PIK3R1 mRNA CTD PMID:20032058 dexamethasone multiple interactions EXP 6480464 Testosterone inhibits the reaction [Dexamethasone results in increased expression of PIK3R1 mRNA] CTD PMID:20032058 diallyl trisulfide multiple interactions EXP 6480464 PIK3R1 protein promotes the reaction [diallyl trisulfide results in increased expression of HMOX1 protein]; more ... CTD PMID:25896937 dibenz[a,h]anthracene increases expression ISO RGD:11103 6480464 1,2,5,6-dibenzanthracene results in increased expression of PIK3R1 mRNA CTD PMID:26377693 diclofenac affects expression ISO RGD:731958 6480464 Diclofenac affects the expression of PIK3R1 mRNA CTD PMID:24752500 diclofenac increases expression ISO RGD:11103 6480464 Diclofenac results in increased expression of PIK3R1 mRNA CTD PMID:26934552 dioxygen multiple interactions EXP 6480464 Quercetin inhibits the reaction [Oxygen deficiency results in increased expression of PIK3R1 mRNA]; more ... CTD PMID:25352008 PMID:26476374 dioxygen decreases phosphorylation EXP 6480464 Oxygen deficiency results in decreased phosphorylation of PIK3R1 protein CTD PMID:25352008 dioxygen increases expression ISO RGD:731958 6480464 Oxygen deficiency results in increased expression of PIK3R1 mRNA CTD PMID:19640849 dioxygen multiple interactions ISO RGD:731958 6480464 PIK3R1 protein promotes the reaction [Oxygen deficiency results in increased expression of CD36 mRNA]; more ... CTD PMID:19640849 dioxygen increases expression EXP 6480464 Oxygen deficiency results in increased expression of PIK3R1 mRNA CTD PMID:26476374 disodium selenite increases expression EXP 6480464 Sodium Selenite results in increased expression of PIK3R1 mRNA CTD PMID:14714311 diuron decreases expression EXP 6480464 Diuron results in decreased expression of PIK3R1 mRNA CTD PMID:21551480 dorsomorphin multiple interactions ISO RGD:731958 6480464 [NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PIK3R1 mRNA CTD PMID:27188386 doxorubicin increases expression ISO RGD:11103 6480464 Doxorubicin results in increased expression of PIK3R1 mRNA CTD PMID:25896364 doxorubicin decreases expression ISO RGD:731958 6480464 Doxorubicin results in decreased expression of PIK3R1 mRNA CTD PMID:29803840 elemental selenium increases expression ISO RGD:11103 6480464 Selenium results in increased expression of PIK3R1 mRNA CTD PMID:28810182 emodin affects expression EXP 6480464 Emodin affects the expression of PIK3R1 protein CTD PMID:19549930 entinostat decreases expression ISO RGD:731958 6480464 entinostat results in decreased expression of PIK3R1 mRNA CTD PMID:26272509 entinostat multiple interactions ISO RGD:731958 6480464 [NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PIK3R1 mRNA CTD PMID:27188386 ethanol affects expression EXP 6480464 Ethanol affects the expression of PIK3R1 mRNA CTD PMID:11772933 ethanol increases expression ISO RGD:11103 6480464 Ethanol results in increased expression of PIK3R1 protein CTD PMID:22459179 ethanol multiple interactions EXP 6480464 N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid inhibits the reaction [Ethanol results in increased expression of PIK3R1 mRNA] CTD PMID:20655511 ethanol increases expression EXP 6480464 Ethanol results in increased expression of PIK3R1 mRNA CTD PMID:20655511 eugenol increases expression EXP 6480464 Eugenol results in increased expression of PIK3R1 mRNA CTD PMID:20724125 eugenol increases expression ISO RGD:11103 6480464 Eugenol results in increased expression of PIK3R1 mRNA CTD PMID:21870829 ferulic acid increases expression ISO RGD:11103 6480464 ferulic acid results in increased expression of PIK3R1 mRNA CTD PMID:21870829 folic acid affects expression ISO RGD:731958 6480464 Folic Acid affects the expression of PIK3R1 mRNA CTD PMID:16361273 fonofos increases methylation ISO RGD:731958 6480464 Fonofos results in increased methylation of PIK3R1 promoter CTD PMID:22847954 formaldehyde decreases expression ISO RGD:731958 6480464 Formaldehyde results in decreased expression of PIK3R1 mRNA CTD PMID:20655997 formaldehyde increases expression ISO RGD:731958 6480464 Formaldehyde results in increased expression of PIK3R1 mRNA CTD PMID:23649840 furan decreases expression EXP 6480464 furan results in decreased expression of PIK3R1 mRNA CTD PMID:25539665 Garcinol multiple interactions ISO RGD:731958 6480464 garcinol results in decreased phosphorylation of and results in decreased activity of PIK3R1 protein CTD PMID:16052481 gedunin decreases expression ISO RGD:731958 6480464 gedunin results in decreased expression of PIK3R1 mRNA CTD PMID:17010675 geldanamycin increases expression ISO RGD:731958 6480464 geldanamycin results in increased expression of PIK3R1 mRNA CTD PMID:26705709 glucose multiple interactions ISO RGD:731958 6480464 Glucose promotes the reaction [PIK3R1 protein binds to IRS1 protein] CTD PMID:10430617 gold atom multiple interactions ISO RGD:11103 6480464 [Gold co-treated with Polyethylene Glycols] results in increased expression of PIK3R1 mRNA CTD PMID:19695318 gold(0) multiple interactions ISO RGD:11103 6480464 [Gold co-treated with Polyethylene Glycols] results in increased expression of PIK3R1 mRNA CTD PMID:19695318 gold(1+) multiple interactions ISO RGD:11103 6480464 [Gold co-treated with Polyethylene Glycols] results in increased expression of PIK3R1 mRNA CTD PMID:19695318 hydrazines decreases expression ISO RGD:11103 6480464 Hydrazines results in decreased expression of PIK3R1 mRNA CTD PMID:21647536 hydrogen peroxide increases phosphorylation ISO RGD:11103 6480464 Hydrogen Peroxide results in increased phosphorylation of PIK3R1 protein CTD PMID:27494022 hydroquinone multiple interactions ISO RGD:731958 6480464 Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [hydroquinone results in increased abundance of Reactive Oxygen Species]]; more ... CTD PMID:28836394 indole-3-methanol affects expression EXP 6480464 indole-3-carbinol affects the expression of PIK3R1 mRNA CTD PMID:21396975 indometacin multiple interactions ISO RGD:731958 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PIK3R1 mRNA; more ... CTD PMID:28628672 iron atom multiple interactions EXP 6480464 Iron promotes the reaction [MAP3K7 protein binds to HRAS protein binds to PIK3R1 protein]; more ... CTD PMID:17172471 iron(0) multiple interactions EXP 6480464 Iron promotes the reaction [MAP3K7 protein binds to HRAS protein binds to PIK3R1 protein]; more ... CTD PMID:17172471 iron(2+) sulfate (anhydrous) multiple interactions EXP 6480464 ferrous sulfate promotes the reaction [MAP3K7 protein binds to HRAS protein binds to PIK3R1 protein]; more ... CTD PMID:17172471 isoprenaline increases expression ISO RGD:11103 6480464 Isoproterenol results in increased expression of PIK3R1 mRNA CTD PMID:20003209 L-ascorbic acid decreases expression EXP 6480464 Ascorbic Acid results in decreased expression of PIK3R1 mRNA CTD PMID:15372504 lead(0) affects expression ISO RGD:731958 6480464 Lead affects the expression of PIK3R1 mRNA CTD PMID:28903495 lead(2+) affects expression ISO RGD:731958 6480464 Lead affects the expression of PIK3R1 mRNA CTD PMID:28903495 linsidomine multiple interactions ISO RGD:11103 6480464 linsidomine inhibits the reaction [INS1 protein binds to PIK3R1 protein]; more ... CTD PMID:19682478 melphalan decreases expression ISO RGD:731958 6480464 Melphalan results in decreased expression of PIK3R1 mRNA CTD PMID:22363485 mercury atom decreases expression EXP 6480464 Mercury results in decreased expression of PIK3R1 mRNA CTD PMID:12730625 mercury(0) decreases expression EXP 6480464 Mercury results in decreased expression of PIK3R1 mRNA CTD PMID:12730625 mercury(2+) decreases expression EXP 6480464 Mercury results in decreased expression of PIK3R1 mRNA CTD PMID:12730625 metformin increases expression ISO RGD:11103 6480464 Metformin results in increased expression of PIK3R1 mRNA CTD PMID:21870829 methamphetamine increases methylation ISO RGD:11103 6480464 Methamphetamine results in increased methylation of PIK3R1 promoter CTD PMID:26307267 methotrexate affects expression ISO RGD:11103 6480464 Methotrexate affects the expression of PIK3R1 mRNA CTD PMID:18502557 methoxychlor increases methylation EXP 6480464 Methoxychlor results in increased methylation of PIK3R1 gene CTD PMID:23303685 methoxychlor decreases expression EXP 6480464 Methoxychlor results in decreased expression of PIK3R1 mRNA CTD PMID:23303685 methylmercury chloride affects expression EXP 6480464 methylmercuric chloride affects the expression of PIK3R1 mRNA CTD PMID:20864626 N-acetyl-L-cysteine multiple interactions ISO RGD:731958 6480464 Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [butylphen results in increased abundance of Reactive Oxygen Species]]; more ... CTD PMID:28836394 N-nitrosodiethylamine increases expression EXP 6480464 Diethylnitrosamine results in increased expression of PIK3R1 mRNA CTD PMID:30423403 N-nitrosodiethylamine multiple interactions EXP 6480464 neferine inhibits the reaction [Diethylnitrosamine results in increased expression of PIK3R1 mRNA] CTD PMID:30423403 Nonylphenol multiple interactions EXP 6480464 wortmannin inhibits the reaction [nonylphenol results in decreased expression of PIK3R1 protein] CTD PMID:27832966 Nonylphenol decreases expression EXP 6480464 nonylphenol results in decreased expression of PIK3R1 protein CTD PMID:27832966 obeticholic acid decreases expression ISO RGD:731958 6480464 obeticholic acid results in decreased expression of PIK3R1 mRNA CTD PMID:27939613 paracetamol decreases expression ISO RGD:731958 6480464 Acetaminophen results in decreased expression of PIK3R1 mRNA CTD PMID:27761495 paraquat increases expression ISO RGD:11103 6480464 Paraquat results in increased expression of PIK3R1 mRNA CTD PMID:12595580 parathion increases methylation ISO RGD:731958 6480464 Parathion results in increased methylation of PIK3R1 promoter CTD PMID:22847954 perfluorooctane-1-sulfonic acid decreases expression ISO RGD:731958 6480464 perfluorooctane sulfonic acid results in decreased expression of PIK3R1 mRNA CTD PMID:27153767 phenobarbital increases expression EXP 6480464 Phenobarbital results in increased expression of PIK3R1 mRNA CTD PMID:12082028 phenobarbital decreases expression ISO RGD:11103 6480464 Phenobarbital results in decreased expression of PIK3R1 mRNA CTD PMID:23091169 PhIP increases expression EXP 6480464 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PIK3R1 mRNA; more ... CTD PMID:12606953 pirinixic acid multiple interactions ISO RGD:731958 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PIK3R1 mRNA CTD PMID:19710929 pirinixic acid affects expression ISO RGD:11103 6480464 pirinixic acid affects the expression of PIK3R1 mRNA CTD PMID:23811191 pirinixic acid increases expression ISO RGD:11103 6480464 pirinixic acid results in increased expression of PIK3R1 mRNA CTD PMID:18445702 propiconazole decreases expression ISO RGD:11103 6480464 propiconazole results in decreased expression of PIK3R1 mRNA CTD PMID:21278054 quercetin decreases expression ISO RGD:731958 6480464 Quercetin results in decreased expression of PIK3R1 protein modified form CTD PMID:26311153 quercetin decreases phosphorylation ISO RGD:11103 6480464 Quercetin results in decreased phosphorylation of PIK3R1 protein CTD PMID:25658812 quercetin multiple interactions EXP 6480464 Quercetin inhibits the reaction [Oxygen deficiency results in increased expression of PIK3R1 mRNA] CTD PMID:26476374 quercitrin affects expression ISO RGD:731958 6480464 quercitrin affects the expression of PIK3R1 mRNA CTD PMID:25193878 reactive oxygen species multiple interactions ISO RGD:731958 6480464 Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [butylphen results in increased abundance of Reactive Oxygen Species]]; more ... CTD PMID:28836394 resveratrol decreases expression ISO RGD:11103 6480464 resveratrol results in decreased expression of PIK3R1 mRNA CTD PMID:22610192 resveratrol increases expression ISO RGD:731958 6480464 resveratrol results in increased expression of PIK3R1 mRNA; more ... CTD PMID:18089832 resveratrol multiple interactions EXP 6480464 resveratrol inhibits the reaction [INS1 protein promotes the reaction [IRS1 protein binds to PIK3R1 protein]]; more ... CTD PMID:16626303 PMID:25352008 resveratrol multiple interactions ISO RGD:731958 6480464 Adenosine Triphosphate inhibits the reaction [resveratrol results in decreased activity of [PIK3R1 protein binds to PIK3CA protein]]; more ... CTD PMID:17550345 retinyl acetate increases expression ISO RGD:11103 6480464 retinol acetate results in increased expression of PIK3R1 mRNA CTD PMID:16772331 SB 431542 multiple interactions ISO RGD:731958 6480464 [NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PIK3R1 mRNA CTD PMID:27188386 selenium atom increases expression ISO RGD:11103 6480464 Selenium results in increased expression of PIK3R1 mRNA CTD PMID:28810182 silicon dioxide decreases expression ISO RGD:11103 6480464 Silicon Dioxide results in decreased expression of PIK3R1 mRNA CTD PMID:19073995 silver atom decreases expression ISO RGD:11103 6480464 Silver results in decreased expression of PIK3R1 mRNA CTD PMID:27131904 silver(0) decreases expression ISO RGD:11103 6480464 Silver results in decreased expression of PIK3R1 mRNA CTD PMID:27131904 silver(1+) decreases expression ISO RGD:11103 6480464 Silver results in decreased expression of PIK3R1 mRNA CTD PMID:27131904 sirolimus multiple interactions ISO RGD:731958 6480464 Sirolimus promotes the reaction [IRS1 protein binds to PIK3R1 protein] CTD PMID:17908691 sodium arsenate increases expression ISO RGD:11103 6480464 sodium arsenate results in increased expression of PIK3R1 mRNA CTD PMID:21795629 sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of PIK3R1 mRNA CTD PMID:19072884 succimer multiple interactions ISO RGD:11103 6480464 [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of PIK3R1 mRNA CTD PMID:21641980 tamoxifen increases expression ISO RGD:11103 6480464 Tamoxifen results in increased expression of PIK3R1 mRNA CTD PMID:20937368 terbufos increases methylation ISO RGD:731958 6480464 terbufos results in increased methylation of PIK3R1 promoter CTD PMID:22847954 tert-butyl hydroperoxide decreases expression ISO RGD:731958 6480464 tert-Butylhydroperoxide results in decreased expression of PIK3R1 mRNA CTD PMID:15336504 testosterone multiple interactions EXP 6480464 Testosterone inhibits the reaction [Dexamethasone results in increased expression of PIK3R1 mRNA] CTD PMID:20032058 thiazolidinediones increases expression ISO RGD:11103 6480464 Thiazolidinediones results in increased expression of PIK3R1 mRNA CTD PMID:21870829 thioacetamide decreases expression EXP 6480464 Thioacetamide results in decreased expression of PIK3R1 mRNA CTD PMID:23411599 titanium dioxide increases expression ISO RGD:11103 6480464 titanium dioxide results in increased expression of PIK3R1 mRNA CTD PMID:23557971 PMID:29128614 trans-caffeic acid increases expression ISO RGD:11103 6480464 caffeic acid results in increased expression of PIK3R1 mRNA CTD PMID:21870829 trans-cinnamic acid increases expression ISO RGD:11103 6480464 cinnamic acid results in increased expression of PIK3R1 mRNA CTD PMID:21870829 trichostatin A decreases expression ISO RGD:731958 6480464 trichostatin A results in decreased expression of PIK3R1 mRNA CTD PMID:24935251 tris(2-butoxyethyl) phosphate affects expression ISO RGD:731958 6480464 tris(2-butoxyethyl) phosphate affects the expression of PIK3R1 mRNA CTD PMID:29024780 tunicamycin decreases expression ISO RGD:11103 6480464 Tunicamycin results in decreased expression of PIK3R1 mRNA CTD PMID:17127020 uranium atom affects expression ISO RGD:731958 6480464 Uranium affects the expression of PIK3R1 mRNA CTD PMID:15672453 urethane increases expression ISO RGD:731958 6480464 Urethane results in increased expression of PIK3R1 mRNA CTD PMID:28818685 valproic acid affects expression ISO RGD:11103 6480464 Valproic Acid affects the expression of PIK3R1 mRNA CTD PMID:17292431 valproic acid increases expression ISO RGD:731958 6480464 Valproic Acid results in increased expression of PIK3R1 mRNA CTD PMID:24935251 vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of PIK3R1 mRNA CTD PMID:23034163 vitamin E decreases expression ISO RGD:731958 6480464 Vitamin E results in decreased expression of PIK3R1 mRNA CTD PMID:19244175 wortmannin decreases activity ISO RGD:731958 6480464 wortmannin results in decreased activity of PIK3R1 protein CTD PMID:19036708 wortmannin multiple interactions EXP 6480464 wortmannin inhibits the reaction [nonylphenol results in decreased expression of PIK3R1 protein] CTD PMID:27832966 zoledronic acid increases expression ISO RGD:731958 6480464 zoledronic acid results in increased expression of PIK3R1 mRNA CTD PMID:24714768
Biological Process aging IEP 1625220 RGD B cell differentiation ISO RGD:11103 1624291 MGI:MGI:2149414 RGD MGI:MGI:1329776 PMID:9988280 B cell differentiation IEA UniProtKB:P26450|ensembl:ENSMUSP00000056774 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular glucose homeostasis IEA UniProtKB:P26450|ensembl:ENSMUSP00000056774 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular glucose homeostasis ISS UniProtKB:P26450 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cellular glucose homeostasis ISO RGD:11103 1624291 RGD MGI:MGI:4442277 PMID:20348926 cellular response to fatty acid IEP 4108505 linoleic acid RGD cellular response to insulin stimulus IEP 4108484 increased IRS1 binding RGD cellular response to insulin stimulus ISS UniProtKB:P26450 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cellular response to insulin stimulus ISO RGD:11103 1624291 RGD MGI:MGI:4442277 more ... cellular response to UV ISO RGD:11103 1624291 MGI:MGI:103296|MGI:MGI:2149414 RGD MGI:MGI:3709926 PMID:17242187 cellular response to UV IEA UniProtKB:P26450|ensembl:ENSMUSP00000056774 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 extrinsic apoptotic signaling pathway via death domain receptors ISO RGD:11103 1624291 MGI:MGI:97306 RGD MGI:MGI:3038547 PMID:15039234 extrinsic apoptotic signaling pathway via death domain receptors IEA UniProtKB:P26450|ensembl:ENSMUSP00000056774 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 glucose metabolic process IMP 1625263 RGD growth hormone receptor signaling pathway ISO RGD:731958 1624291 RGD PMID:7782332 growth hormone receptor signaling pathway IEA UniProtKB:P27986|ensembl:ENSP00000428056 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 insulin receptor signaling pathway IMP 1625251 RGD insulin receptor signaling pathway IBA MGI:MGI:109277|MGI:MGI:1098772|MGI:MGI:97583|PANTHER:PTN000016388|RGD:3329|UniProtKB:P23727|WB:WBGene00000001 13792537 PMID:21873635 GO_Central insulin receptor signaling pathway ISO RGD:11103 1624291 RGD MGI:MGI:4442277 PMID:20348926 insulin receptor signaling pathway IEA UniProtKB:P26450|ensembl:ENSMUSP00000056774 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 insulin receptor signaling pathway ISS UniProtKB:P27986 1600115 GO_REF:0000024 UniProt GO_REF:0000024 insulin-like growth factor receptor signaling pathway IMP 1625263 RGD insulin-like growth factor receptor signaling pathway ISS UniProtKB:P27986 1600115 GO_REF:0000024 UniProt GO_REF:0000024 insulin-like growth factor receptor signaling pathway IEA UniProtKB:P27986|ensembl:ENSP00000428056 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 insulin-like growth factor receptor signaling pathway ISO RGD:731958 1624291 UniProtKB:P08069 RGD PMID:7541045 PMID:7782332 intrinsic apoptotic signaling pathway in response to DNA damage ISO RGD:11103 1624291 MGI:MGI:104798|MGI:MGI:2149414 RGD MGI:MGI:3709926 PMID:17242187 intrinsic apoptotic signaling pathway in response to DNA damage IEA UniProtKB:P26450|ensembl:ENSMUSP00000056774 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of apoptotic process ISO RGD:731958 1624291 RGD PMID:20348923 negative regulation of apoptotic process ISS UniProtKB:P27986 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of apoptotic process IEA UniProtKB:P27986|ensembl:ENSP00000428056 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of apoptotic process IEA UniProtKB:P26450|ensembl:ENSMUSP00000056774 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of apoptotic process ISO RGD:11103 1624291 RGD MGI:MGI:3047434 PMID:15192701 negative regulation of blood pressure IMP 4108483 RGD negative regulation of cell adhesion ISO RGD:11103 1624291 RGD MGI:MGI:5613738 PMID:25217619 negative regulation of cell-cell adhesion IMP 1641930 gastrin-induced RGD negative regulation of cell-matrix adhesion ISO RGD:11103 1624291 MGI:MGI:97306 RGD MGI:MGI:3689489 PMID:17053831 negative regulation of cell-matrix adhesion IEA UniProtKB:P26450|ensembl:ENSMUSP00000056774 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of heart rate IMP 4108483 RGD negative regulation of muscle cell apoptotic process IMP 1625255 RGD negative regulation of osteoclast differentiation ISO RGD:11103 1624291 MGI:MGI:97306 RGD MGI:MGI:3689489 PMID:17053831 negative regulation of osteoclast differentiation IEA UniProtKB:P26450|ensembl:ENSMUSP00000056774 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of proteolysis IMP 1625251 RGD negative regulation of smooth muscle cell proliferation IMP 4107736 cAMP-dependent RGD phosphatidylinositol 3-kinase signaling ISO RGD:731958 1624291 RGD PMID:21321938 PMID:7782332 phosphatidylinositol 3-kinase signaling IEA UniProtKB:P27986|ensembl:ENSP00000428056 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 phosphatidylinositol phosphorylation ISS UniProtKB:O18683 1600115 GO_REF:0000024 UniProt GO_REF:0000024 phosphatidylinositol phosphorylation IBA FB:FBgn0020622|PANTHER:PTN000806614|UniProtKB:P23727 13792537 PMID:21873635 GO_Central phosphatidylinositol-3-phosphate biosynthetic process IEA GO:0016303 1600115 GO_REF:0000108 GOC GO_REF:0000108 positive regulation of cell migration IMP 1641930 gastrin-induced RGD positive regulation of cell migration IEA UniProtKB:P26450|ensembl:ENSMUSP00000056774 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of cell migration ISO RGD:11103 1624291 MGI:MGI:97306 RGD MGI:MGI:3689489 PMID:17053831 positive regulation of endoplasmic reticulum unfolded protein response ISO RGD:731958 1624291 RGD PMID:20348923 positive regulation of endoplasmic reticulum unfolded protein response ISS UniProtKB:P27986 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of endoplasmic reticulum unfolded protein response IEA UniProtKB:P27986|ensembl:ENSP00000428056 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of gene expression IMP 2324995 COX-2 RGD positive regulation of myoblast differentiation IMP 1625263 RGD positive regulation of protein import into nucleus ISS UniProtKB:P26450 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of protein import into nucleus ISO RGD:11103 1624291 RGD MGI:MGI:4442277 PMID:20348926 positive regulation of protein import into nucleus ISO RGD:731958 1624291 RGD PMID:20348923 positive regulation of protein import into nucleus IEA UniProtKB:P27986|ensembl:ENSP00000428056 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of protein import into nucleus IEA UniProtKB:P26450|ensembl:ENSMUSP00000056774 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of protein import into nucleus ISS UniProtKB:P27986 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of protein phosphorylation IMP 4107737 H-ras-induced JNK activation RGD positive regulation of RNA splicing ISO RGD:731958 1624291 RGD PMID:20348923 positive regulation of RNA splicing ISS UniProtKB:P27986 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of RNA splicing IEA UniProtKB:P27986|ensembl:ENSP00000428056 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of transcription by RNA polymerase II ISO RGD:731958 1624291 RGD PMID:20348923 positive regulation of transcription by RNA polymerase II ISS UniProtKB:P27986 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of transcription by RNA polymerase II ISS UniProtKB:P26450 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of transcription by RNA polymerase II IEA UniProtKB:P27986|ensembl:ENSP00000428056 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of transcription by RNA polymerase II IEA UniProtKB:P26450|ensembl:ENSMUSP00000056774 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of transcription by RNA polymerase II ISO RGD:11103 1624291 MGI:MGI:2149414 RGD MGI:MGI:3709926 more ... positive regulation of tumor necrosis factor production ISO RGD:11103 1624291 RGD MGI:MGI:3709926 PMID:17242187 positive regulation of tumor necrosis factor production IEA UniProtKB:P26450|ensembl:ENSMUSP00000056774 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein import into nucleus ISO RGD:11103 1624291 MGI:MGI:2149414 RGD MGI:MGI:3709926 PMID:17242187 protein import into nucleus IEA UniProtKB:P26450|ensembl:ENSMUSP00000056774 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein phosphorylation ISO RGD:11103 1624291 RGD MGI:MGI:3047434 PMID:15192701 protein phosphorylation IEA UniProtKB:P26450|ensembl:ENSMUSP00000056774 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein stabilization ISO RGD:731958 1624291 RGD PMID:20348923 protein stabilization ISS UniProtKB:P27986 1600115 GO_REF:0000024 UniProt GO_REF:0000024 protein stabilization IEA UniProtKB:P27986|ensembl:ENSP00000428056 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein transport IEA UniProtKB-KW:KW-0653 1600115 GO_REF:0000037 UniProt GO_REF:0000037 regulation of insulin receptor signaling pathway ISO RGD:11103 1624291 MGI:MGI:88315 RGD MGI:MGI:5755307 PMID:26657864 regulation of insulin receptor signaling pathway IEA UniProtKB:P26450|ensembl:ENSMUSP00000056774 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of phosphatidylinositol 3-kinase activity IDA 4144086 RGD regulation of phosphatidylinositol 3-kinase activity IBA PANTHER:PTN000016388|RGD:3329|UniProtKB:P23727 13792537 PMID:21873635 GO_Central regulation of phosphatidylinositol 3-kinase activity IEA GO:0035014 1600115 GO_REF:0000108 GOC GO_REF:0000108 regulation of protein localization to plasma membrane ISO RGD:11103 1624291 RGD MGI:MGI:5613738 PMID:25217619 regulation of protein localization to plasma membrane IEA UniProtKB:P26450|ensembl:ENSMUSP00000056774 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of stress fiber assembly ISO RGD:11103 1624291 MGI:MGI:2149438 RGD MGI:MGI:5613738 PMID:25217619 regulation of stress fiber assembly IEA UniProtKB:P26450|ensembl:ENSMUSP00000056774 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 response to amino acid IEP 4108480 arginine RGD response to cAMP IDA 1625260 RGD response to dexamethasone IEP 4107733 RGD response to drug IEP 4107731 phenylephrine RGD response to endoplasmic reticulum stress ISO RGD:731958 1624291 RGD PMID:20348923 response to endoplasmic reticulum stress ISS UniProtKB:P27986 1600115 GO_REF:0000024 UniProt GO_REF:0000024 response to endoplasmic reticulum stress ISS UniProtKB:P26450 1600115 GO_REF:0000024 UniProt GO_REF:0000024 response to endoplasmic reticulum stress ISO RGD:11103 1624291 RGD MGI:MGI:4442277 PMID:20348926 response to endoplasmic reticulum stress IEA UniProtKB:P27986|ensembl:ENSP00000428056 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 response to endoplasmic reticulum stress IEA UniProtKB:P26450|ensembl:ENSMUSP00000056774 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 response to estradiol IEP 4108478 RGD response to ethanol IEP 4108503 RGD response to fatty acid IEP 4108479 ethyl eicosapentaenoic acid RGD response to fructose IEP 4108494 RGD response to glucocorticoid IDA 1625221 RGD response to growth factor IEP 4108491 PDGF RGD response to insulin IDA 1625213 RGD response to iron(II) ion IEP 4108504 FeSO4 RGD response to nutrient IEP 4107735 soybean diet RGD response to nutrient IEP 4108477 high-fat diet RGD response to progesterone IEP 4108487 RGD response to testosterone IEP 4107733 RGD response to yeast IEP 4107734 Saccharomyces boulardii RGD Cellular Component cell-cell junction ISO RGD:11103 1624291 RGD MGI:MGI:5544872 PMID:23793062 cell-cell junction IEA UniProtKB:P26450|ensembl:ENSMUSP00000056774 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 cis-Golgi network ISO RGD:11103 1624291 RGD MGI:MGI:5613738 PMID:25217619 cis-Golgi network IEA UniProtKB:P26450|ensembl:ENSMUSP00000056774 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 cytoplasm ISO RGD:731958 1624291 RGD PMID:20348923 cytoplasm ISO RGD:11103 1624291 RGD MGI:MGI:3689804 PMID:16043515 cytosol TAS 1600115 Reactome:R-RNO-912619 Reactome Reactome:R-RNO-912619 cytosol ISO RGD:11103 1624291 RGD MGI:MGI:3689804 PMID:16043515 cytosol IEA UniProtKB:P26450|ensembl:ENSMUSP00000056774 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 membrane IDA 4107731 RGD membrane ISO RGD:11103 1624291 RGD MGI:MGI:3689804 PMID:16043515 neuron projection IDA 4108504 RGD nucleus IDA 4108495 RGD nucleus ISO RGD:11103 1624291 RGD MGI:MGI:4442277 PMID:20348926 nucleus IEA UniProtKB:P26450|ensembl:ENSMUSP00000056774 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 perinuclear endoplasmic reticulum membrane ISO RGD:11103 1624291 RGD MGI:MGI:5613738 PMID:25217619 perinuclear endoplasmic reticulum membrane IEA UniProtKB:P26450|ensembl:ENSMUSP00000056774 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 phosphatidylinositol 3-kinase complex TAS 68289 RGD phosphatidylinositol 3-kinase complex IBA MGI:MGI:109277|PANTHER:PTN000806614|RGD:3329|UniProtKB:P23727|WB:WBGene00000001 13792537 PMID:21873635 GO_Central phosphatidylinositol 3-kinase complex IEA InterPro:IPR001720 1600115 GO_REF:0000002 InterPro GO_REF:0000002 phosphatidylinositol 3-kinase complex IDA 4144086 RGD phosphatidylinositol 3-kinase complex IDA 4107732 RGD phosphatidylinositol 3-kinase complex, class IA ISS UniProtKB:O18683 1600115 GO_REF:0000024 UniProt GO_REF:0000024 plasma membrane IDA 1625216 RGD protein-containing complex IDA 2303503 RGD protein-containing complex ISO RGD:11103 1624291 RGD MGI:MGI:5755307 PMID:26657864 Molecular Function 1-phosphatidylinositol-3-kinase activity TAS 68289 RGD 1-phosphatidylinositol-3-kinase activity contributes_to IDA 4107732 RGD 1-phosphatidylinositol-3-kinase regulator activity IDA 4144086 RGD 1-phosphatidylinositol-3-kinase regulator activity IBA MGI:MGI:109277|PANTHER:PTN000806614|RGD:3329|RGD:621042 13792537 PMID:21873635 GO_Central ATPase binding IPI RGD:2167 4108501 RGD calmodulin binding IPI RGD:2257 4108506 RGD ErbB-3 class receptor binding ISO RGD:731958 1624291 RGD PMID:10572067 ErbB-3 class receptor binding ISS UniProtKB:P27986 1600115 GO_REF:0000024 UniProt GO_REF:0000024 ErbB-3 class receptor binding IEA UniProtKB:P27986|ensembl:ENSP00000428056 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 estrogen receptor binding IPI RGD:2581 1625219 RGD insulin binding ISO RGD:731958 1624291 RGD PMID:8440175 insulin binding IEA UniProtKB:P27986|ensembl:ENSP00000428056 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 insulin receptor binding ISO RGD:731958 1624291 UniProtKB:P06213 RGD PMID:7537849 insulin receptor binding ISS UniProtKB:P27986 1600115 GO_REF:0000024 UniProt GO_REF:0000024 insulin receptor binding IEA UniProtKB:P27986|ensembl:ENSP00000428056 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 insulin receptor substrate binding IPI RGD:2922 1299201 RGD insulin receptor substrate binding ISS UniProtKB:P26450 1600115 GO_REF:0000024 UniProt GO_REF:0000024 insulin receptor substrate binding ISO RGD:11103 1624291 UniProtKB:P35568 RGD MGI:MGI:3689804 PMID:16043515 insulin receptor substrate binding IEA UniProtKB:P26450|ensembl:ENSMUSP00000056774 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 insulin receptor substrate binding IPI RGD:69316 1299201 RGD insulin-like growth factor receptor binding ISO RGD:731958 1624291 UniProtKB:P08069 RGD PMID:7541045 insulin-like growth factor receptor binding ISS UniProtKB:P27986 1600115 GO_REF:0000024 UniProt GO_REF:0000024 insulin-like growth factor receptor binding IEA UniProtKB:P27986|ensembl:ENSP00000428056 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 neurotrophin TRKA receptor binding ISO RGD:731958 1624291 UniProtKB:P04629 RGD PMID:15488758 neurotrophin TRKA receptor binding IEA UniProtKB:P27986|ensembl:ENSP00000428056 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 phosphatidylinositol 3-kinase regulator activity IEA InterPro:IPR001720 1600115 GO_REF:0000002 InterPro GO_REF:0000002 phosphatidylinositol 3-kinase regulator activity ISS UniProtKB:O18683 1600115 GO_REF:0000024 UniProt GO_REF:0000024 phosphatidylinositol 3-kinase regulatory subunit binding ISO RGD:11103 1624291 UniProtKB:O08908 RGD MGI:MGI:4442277 PMID:20348926 phosphatidylinositol 3-kinase regulatory subunit binding IEA UniProtKB:P26450|ensembl:ENSMUSP00000056774 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 phosphoprotein binding IPI RGD:628770 1299347 RGD phosphotyrosine residue binding IEA UniProtKB:P27986|ensembl:ENSP00000428056 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 phosphotyrosine residue binding ISO RGD:731958 1624291 UniProtKB:Q6GX35 RGD PMID:20624904 platelet-derived growth factor receptor binding IPI RGD:3284 RGD:3285 4108491 RGD protein binding IPI UniProtKB:Q91V33 8553603 PMID:10437794 IntAct protein binding ISO RGD:11103 1624291 UniProtKB:O35904-2|UniProtKB:O88665|UniProtKB:P05622|UniProtKB:P34152|UniProtKB:P35569|UniProtKB:P37242|UniProtKB:P42337|UniProtKB:P49769|UniProtKB:P81122|UniProtKB:Q60974|UniProtKB:Q62448|UniProtKB:Q6SP97|UniProtKB:Q8BTI9|UniProtKB:Q8IZP0|UniProtKB:Q8K3G9|UniProtKB:Q8K3H0|UniProtKB:Q8R5H6|UniProtKB:Q91VW7|UniProtKB:Q9D828|UniProtKB:Q9EQ32|UniProtKB:Q9EQR5|UniProtKB:Q9JLY0|UniProtKB:Q9R1X3|UniProtKB:Q9WVS0 RGD MGI:MGI:1928540 more ... protein binding ISO RGD:731958 1624291 UniProtKB:O00329|UniProtKB:O15455|UniProtKB:O43493|UniProtKB:O43561|UniProtKB:P00533|UniProtKB:P03372|UniProtKB:P03496|UniProtKB:P04626|UniProtKB:P06213|UniProtKB:P08069|UniProtKB:P08581|UniProtKB:P09619|UniProtKB:P0DOJ9|UniProtKB:P10275|UniProtKB:P10721|UniProtKB:P10747|UniProtKB:P11362|UniProtKB:P12931|UniProtKB:P16410|UniProtKB:P16885|UniProtKB:P17948|UniProtKB:P19793|UniProtKB:P21860|UniProtKB:P22681|UniProtKB:P26373|UniProtKB:P29353|UniProtKB:P30874|UniProtKB:P35568|UniProtKB:P35570|UniProtKB:P36888|UniProtKB:P41970|UniProtKB:P42336|UniProtKB:P42338|UniProtKB:P42684|UniProtKB:P42858|UniProtKB:P45983|UniProtKB:P46108|UniProtKB:P46109|UniProtKB:P48023|UniProtKB:P49023|UniProtKB:P58753|UniProtKB:P62993|UniProtKB:Q07889|UniProtKB:Q13111|UniProtKB:Q13322|UniProtKB:Q13480|UniProtKB:Q13905|UniProtKB:Q15661|UniProtKB:Q5T0W9|UniProtKB:Q6PFX7|UniProtKB:Q86VI4-3|UniProtKB:Q8BM65-4|UniProtKB:Q8IUH5|UniProtKB:Q8IY22|UniProtKB:Q8IZP0|UniProtKB:Q8WX92|UniProtKB:Q92918|UniProtKB:Q96EB6|UniProtKB:Q99152|UniProtKB:Q9H0K1|UniProtKB:Q9NP31|UniProtKB:Q9PVZ4|UniProtKB:Q9UKC9|UniProtKB:Q9UKW4|UniProtKB:Q9ULW0|UniProtKB:Q9UPX8|UniProtKB:Q9Y2H0|UniProtKB:Q9Y4H2|UniProtKB:Q9Y6W8 RGD PMID:10500481 more ... protein binding IPI UniProtKB:P21575 8554440 PMID:17437541 IntAct protein binding IPI UniProtKB:A0MZ67 8554246 PMID:17030985 IntAct protein binding IPI UniProtKB:P62813 8554051 PMID:16890252 IntAct protein binding IPI UniProtKB:P18545 8554657 PMID:16357825 IntAct protein binding IPI UniProtKB:P35570 8553525 PMID:12446583 IntAct protein binding IPI UniProtKB:P35570 8553709 PMID:11136729 IntAct protein C-terminus binding IDA 1304375 RGD protein domain specific binding IPI RGD:621367 2303503 RGD protein domain specific binding IPI RGD:619758 2303503 RGD protein heterodimerization activity ISO RGD:11103 1624291 UniProtKB:O08908 RGD MGI:MGI:4442277 PMID:20348926 protein heterodimerization activity IEA UniProtKB:P26450|ensembl:ENSMUSP00000056774 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein kinase binding IPI RGD:3443 4108485 RGD protein kinase binding IPI RGD:2939 1641930 RGD protein phosphatase binding ISO RGD:731958 1624291 UniProtKB:Q12959 RGD PMID:14699157 protein phosphatase binding IEA UniProtKB:P27986|ensembl:ENSP00000428056 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 receptor tyrosine kinase binding IPI RGD:620028 4108493 RGD signaling receptor binding IPI RGD:3870 1302746 RGD transcription factor binding ISO RGD:731958 1624291 UniProtKB:P17861-2 RGD PMID:20348923 transcription factor binding ISO RGD:11103 1624291 UniProtKB:O08908|UniProtKB:O35426-2 RGD MGI:MGI:4442277 PMID:20348926 transcription factor binding IEA UniProtKB:P27986|ensembl:ENSP00000428056 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 transcription factor binding IEA UniProtKB:P26450|ensembl:ENSMUSP00000056774 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 ubiquitin protein ligase binding IPI RGD:1561386 4108486 RGD
Gene-Chemical Interaction Annotations
