Gene: Ptpn11 (protein tyrosine phosphatase, non-receptor type 11) Rattus norvegicus
Symbol: Ptpn11
Name: protein tyrosine phosphatase, non-receptor type 11
Description: ENCODES a protein that exhibits cell adhesion molecule binding; D1 dopamine receptor binding; insulin receptor binding; INVOLVED IN cellular response to mechanical stimulus; protein dephosphorylation; abortive mitotic cell cycle (ortholog); PARTICIPATES IN insulin signaling pathway; somatostatin signaling pathway; epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH Fetal Growth Retardation; Adenocarcinoma (ortholog); ADENOCARCINOMA OF STOMACH (ortholog); FOUND IN cytosol; mitochondrion; protein complex; INTERACTS WITH 15-deoxy-Delta(12,14)-prostaglandin J2; 2,4-dinitrotoluene; 2,6-dinitrotoluene
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: encodes catalytic domain; protein tyrosine phosphatase SH-PTP2; protein-tyrosine phosphatase 1D; protein-tyrosine phosphatase SYP; PTP-1D; SH-PTP2 protein tyrosine phosphatase non-receptor type 11; SH-PTP2 protein tyrosine phosphatase, non-receptor type 11; SHP-2; Shp2; tyrosine-protein phosphatase non-receptor type 11
Allele / Splice: Ptpn11em4Mcwi   Ptpn11em1Mcwi  
Genetic Models: SS-Ptpn11em4Mcwi SS-Ptpn11em1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01240,895,515 - 40,955,999 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01242,762,630 - 42,822,760 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41236,501,886 - 36,558,055 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11236,365,273 - 36,421,443 (+)NCBI
Celera1237,029,879 - 37,089,260 (+)NCBICelera
Cytogenetic Map12q16NCBI
RH 3.4 Map12646.0RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Ptpn11
AGR Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3447
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2017-11-07
Status: ACTIVE