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Gene: Ptpn11 (protein tyrosine phosphatase, non-receptor type 11) Rattus norvegicus
Symbol: Ptpn11
Name: protein tyrosine phosphatase, non-receptor type 11
Description: Exhibits several functions, including insulin receptor substrate binding activity; phospholipase binding activity; and signaling receptor binding activity. Involved in cellular response to mechanical stimulus and protein dephosphorylation. Localizes to cytosol; mitochondrion; and protein-containing complex. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); Noonan syndrome with multiple lentigines (multiple); juvenile myelomonocytic leukemia; metachondromatosis; and tetralogy of Fallot. Orthologous to human PTPN11 (protein tyrosine phosphatase non-receptor type 11); PARTICIPATES IN insulin signaling pathway; somatostatin signaling pathway; epidermal growth factor/neuregulin signaling pathway; INTERACTS WITH 15-deoxy-Delta(12,14)-prostaglandin J2; 2,4-dibromophenyl 2,4,5-tribromophenyl ether; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: encodes catalytic domain; protein tyrosine phosphatase SH-PTP2; protein-tyrosine phosphatase 1D; protein-tyrosine phosphatase SYP; PTP-1D; SH-PTP2 protein tyrosine phosphatase non-receptor type 11; SH-PTP2 protein tyrosine phosphatase, non-receptor type 11; SHP-2; Shp2; tyrosine-protein phosphatase non-receptor type 11
Allele / Splice: Ptpn11em4Mcwi   Ptpn11em1Mcwi  
Genetic Models: SS-Ptpn11em4Mcwi SS-Ptpn11em1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01240,895,515 - 40,955,999 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1240,895,515 - 40,955,999 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01242,762,630 - 42,822,760 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41236,501,886 - 36,558,055 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11236,365,273 - 36,421,443 (+)NCBI
Celera1237,029,879 - 37,089,260 (+)NCBICelera
Cytogenetic Map12q16NCBI
RH 3.4 Map12646.0RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Ptpn11
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3447
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.