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Gene: Ptpn11 (protein tyrosine phosphatase, non-receptor type 11) Mus musculus
Symbol: Ptpn11
Name: protein tyrosine phosphatase, non-receptor type 11
Description: Exhibits cell adhesion molecule binding activity; protein tyrosine phosphatase activity; and signaling receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of cytokine production; and regulation of hormone secretion. Predicted to localize to several cellular components, including the cell junction; mitochondrion; and stress fiber. Used to study several diseases, including LEOPARD syndrome; Noonan syndrome 1; hepatocellular adenoma; intrinsic cardiomyopathy (multiple); and juvenile myelomonocytic leukemia. Human ortholog(s) of this gene implicated in LEOPARD syndrome (multiple); Noonan syndrome (multiple); chondroma; juvenile myelomonocytic leukemia; and tetralogy of Fallot. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human PTPN11 (protein tyrosine phosphatase non-receptor type 11); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; erythropoietin signaling pathway; fibroblast growth factor signaling pathway; INTERACTS WITH 1,4-dichlorobenzene; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2700084A17Rik; AW536184; protein-tyrosine phosphatase SYP; PTP1D; PTP2C; SAP-2; SH-PTP2; SH-PTP3; SH2 domain-containing protein tyrosine phosphatase-2; SHP-2; Shp2; Syp; tyrosine-protein phosphatase non-receptor type 11
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl5121,130,533 - 121,191,397 (-)Ensembl
GRCm385121,130,533 - 121,191,397 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv375121,580,542 - 121,641,406 (-)NCBIGRCm37mm9NCBIm37
MGSCv365121,391,158 - 121,451,946 (-)NCBImm8
Celera5118,220,712 - 118,281,623 (-)NCBICelera
Cytogenetic Map5 FNCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Ptpn11
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731747
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-02-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.