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Gene: Shc1 (SHC adaptor protein 1) Rattus norvegicus
Symbol: Shc1
Name: SHC adaptor protein 1
RGD ID: 620446
Description: Exhibits enzyme binding activity; epidermal growth factor receptor binding activity; and phosphotyrosine residue binding activity. Involved in several processes, including activation of MAPK activity; positive regulation of vasoconstriction; and response to peptide hormone. Localizes to Shc-EGFR complex; endosome membrane; and nucleus. Biomarker of familial hyperlipidemia and hepatocellular carcinoma. Orthologous to human SHC1 (SHC adaptor protein 1); PARTICIPATES IN mitogen activated protein kinase signaling pathway; the extracellular signal-regulated Raf/Mek/Erk signaling pathway; brain-derived neurotrophic factor signaling pathway; INTERACTS WITH (+)-schisandrin B; (R)-noradrenaline; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: P66shc; SH2 domain protein C1; SHC (Src homology 2 domain containing) transforming protein 1; SHC (Src homology 2 domain-containing) transforming protein 1; SHC-transforming protein 1; src homology 2 domain-containing transforming protein C1; src homology 2 domain-containing-transforming protein C1
Homo sapiens (human) : SHC1 (SHC adaptor protein 1)  HGNC  Alliance
Mus musculus (house mouse) : Shc1 (src homology 2 domain-containing transforming protein C1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Shc1 (SHC adaptor protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SHC1 (SHC adaptor protein 1)
Canis lupus familiaris (dog) : SHC1 (SHC adaptor protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Shc1 (SHC adaptor protein 1)
Sus scrofa (pig) : SHC1 (SHC adaptor protein 1)
Chlorocebus sabaeus (African green monkey) : SHC1 (SHC adaptor protein 1)
Heterocephalus glaber (naked mole-rat) : Shc1 (SHC adaptor protein 1)
more info ...
Allele / Splice: Shc1em1Mcwi   Shc1em3Mcwi   Shc1em4Mcwi   Shc1em5Mcwi  
Genetic Models: SS-Shc1em1Mcwi SS-Shc1em5Mcwi SS-Shc1em3Mcwi SS-Shc1em4Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02188,745,503 - 188,757,066 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2188,745,503 - 188,757,066 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02208,159,786 - 208,171,348 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42181,616,581 - 181,628,144 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12181,570,194 - 181,572,439 (+)NCBI
Celera2168,778,680 - 168,790,241 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Shc1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620446
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.