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Gene: Grb2 (growth factor receptor bound protein 2) Mus musculus
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Symbol: Grb2
Name: growth factor receptor bound protein 2
Description: Exhibits several functions, including SH3/SH2 adaptor activity; ephrin receptor binding activity; and protein phosphatase binding activity. Involved in several processes, including branching involved in labyrinthine layer morphogenesis; fibroblast growth factor receptor signaling pathway; and positive regulation of actin filament polymerization. Localizes to several cellular components, including the COP9 signalosome; cell-cell junction; and vesicle membrane. Human ortholog(s) of this gene implicated in breast cancer; prostate adenocarcinoma; and prostate cancer. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and lung. Orthologous to human GRB2 (growth factor receptor bound protein 2).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AA408164; adapter protein GRB2; Ash; growth factor receptor-bound protein 2; SH2/SH3 adapter GRB2
Orthologs:
Homo sapiens (human) : GRB2 (growth factor receptor bound protein 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Grb2 (growth factor receptor bound protein 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Grb2 (growth factor receptor bound protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : GRB2 (growth factor receptor bound protein 2)
Canis lupus familiaris (dog) : GRB2 (growth factor receptor bound protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grb2 (growth factor receptor bound protein 2)
Sus scrofa (pig) : GRB2 (growth factor receptor bound protein 2)
more info ...
Related Pseudogenes: Gm12791  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3811115,644,045 - 115,708,597 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3711115,505,444 - 115,569,911 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611115,460,220 - 115,524,687 (-)NCBImm8
Celera11127,412,389 - 127,476,946 (-)NCBICelera
Cytogenetic Map11 E2NCBI
cM Map1180.91NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Grb2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732474
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-11-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.