Grb2 (growth factor receptor bound protein 2) - Rat Genome Database

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Gene: Grb2 (growth factor receptor bound protein 2) Rattus norvegicus
Symbol: Grb2
Name: growth factor receptor bound protein 2
RGD ID: 619758
Description: Enables several functions, including epidermal growth factor receptor binding activity; insulin receptor substrate binding activity; and phosphotyrosine residue binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; cellular response to ionizing radiation; and signal transduction in response to DNA damage. Predicted to act upstream of or within several processes, including embryonic morphogenesis; fibroblast growth factor receptor signaling pathway; and positive regulation of actin filament polymerization. Part of protein-containing complex. Human ortholog(s) of this gene implicated in breast cancer; prostate adenocarcinoma; and prostate cancer. Orthologous to human GRB2 (growth factor receptor bound protein 2); PARTICIPATES IN insulin signaling pathway; insulin-like growth factor signaling pathway; brain-derived neurotrophic factor signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adapter protein GRB2; Ash-psi; growth factor receptor-bound protein 2; growth factor receptor-bound protein 2-like; LOC103690155; MGC108668; protein Ash; SH2/SH3 adapter GRB2; uncharacterized LOC103690155
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.210100,881,404 - 100,949,193 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10100,869,718 - 100,949,309 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10105,941,694 - 106,010,414 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010105,404,767 - 105,473,487 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010100,802,375 - 100,870,155 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010104,193,953 - 104,263,071 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10104,193,955 - 104,263,071 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010104,019,823 - 104,087,251 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.010104,735,560 - 104,738,091 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410105,722,014 - 105,818,649 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110105,737,088 - 105,833,269 (-)NCBI
Celera1099,455,840 - 99,524,352 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Tetrandrine  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
AICA ribonucleotide  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsenic acid  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
Benoxacor  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
bufalin  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
casticin  (ISO)
cerium trichloride  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
choline  (EXP)
chrysin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cypermethrin  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diarsenic trioxide  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
finasteride  (EXP)
flavonoids  (EXP)
folic acid  (EXP,ISO)
gallic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
ivermectin  (ISO)
L-methionine  (EXP)
letrozole  (ISO)
maneb  (ISO)
melatonin  (ISO)
methamphetamine  (EXP)
methapyrilene  (ISO)
microcystin-LR  (EXP)
mifepristone  (ISO)
N-methyl-N-nitrosourea  (EXP)
nickel atom  (ISO)
nitric oxide  (ISO)
Nonidet P-40  (ISO)
ouabain  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctanoic acid  (EXP)
phenylarsine oxide  (EXP)
phosphane  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP)
propiconazole  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
sodium arsenite  (EXP,ISO)
sorafenib  (ISO)
sulindac  (EXP)
tert-butyl hydroperoxide  (ISO)
titanium dioxide  (ISO)
trimethyltin  (ISO)
Triptolide  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell cortex  (IEA,ISO)
cell-cell junction  (IEA,ISO)
COP9 signalosome  (IBA,IEA,ISO,ISS)
cytoplasm  (IBA,ISO,ISS)
cytosol  (TAS)
endosome  (IEA,ISO,ISS)
Golgi apparatus  (IEA)
Grb2-EGFR complex  (IEA,ISO)
membrane  (ISO)
nucleolus  (IEA,ISO)
nucleoplasm  (IBA,IEA,ISO)
nucleus  (ISO,ISS)
plasma membrane  (IBA,ISO)
protein-containing complex  (IDA)
vesicle membrane  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
acute myeloid leukemia pathway  (IEA)
B cell receptor signaling pathway  (IEA)
brain-derived neurotrophic factor signaling pathway  (ISO)
chemokine mediated signaling pathway  (IEA)
chronic myeloid leukemia pathway  (IEA)
endometrial cancer pathway  (IEA)
ephrin - ephrin receptor bidirectional signaling axis  (ISO)
epidermal growth factor/neuregulin signaling pathway  (IEA,ISO)
erythropoietin signaling pathway  (ISO)
Fc epsilon receptor mediated signaling pathway  (IEA,ISO)
fibroblast growth factor signaling pathway  (ISO)
glioma pathway  (IEA)
gonadotropin-releasing hormone signaling pathway  (IEA)
granulocyte-macrophage colony-stimulating factor signaling pathway  (ISO)
hepatitis C pathway  (IEA)
insulin signaling pathway  (IDA,IEA,ISO)
insulin-like growth factor signaling pathway  (IMP,ISO)
interleukin-2 signaling pathway  (ISO)
interleukin-3 signaling pathway  (ISO)
interleukin-4 signaling pathway  (ISO)
interleukin-5 signaling pathway  (ISO)
interleukin-6 signaling pathway  (ISO)
Jak-Stat signaling pathway  (IEA)
mitogen activated protein kinase signaling pathway  (IEA)
neurotrophic factor signaling pathway  (IEA)
non-small cell lung carcinoma pathway  (IEA)
platelet-derived growth factor signaling pathway  (ISO)
prostate cancer pathway  (IEA)
renal cell carcinoma pathway  (IEA)
scatter factor/hepatocyte growth factor signaling pathway  (ISO)
T cell receptor signaling pathway  (IEA)
transforming growth factor-beta Smad dependent signaling pathway  (ISO)
vascular endothelial growth factor signaling pathway  (ISO)


References - curated
# Reference Title Reference Citation
1. Grb2 monomer-dimer equilibrium determines normal versus oncogenic function. Ahmed Z, etal., Nat Commun. 2015 Jun 24;6:7354. doi: 10.1038/ncomms8354.
2. Syndapin I and endophilin I bind overlapping proline-rich regions of dynamin I: role in synaptic vesicle endocytosis. Anggono V and Robinson PJ, J Neurochem. 2007 Aug;102(3):931-43. Epub 2007 Apr 16.
3. Met, metastasis, motility and more. Birchmeier C, etal., Nat Rev Mol Cell Biol. 2003 Dec;4(12):915-25.
4. Repetitive peroxide exposure reveals pleiotropic mitogen-activated protein kinase signaling mechanisms. Chadwick W, etal., J Signal Transuct. 2011;2011. pii: 636951.
5. Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation. Cheng AM, etal., Cell 1998 Dec 11;95(6):793-803.
6. SLP-76-Cbl-Grb2-Shc interactions in FcgammaRI signaling. Chu J, etal., Blood. 1998 Sep 1;92(5):1697-706.
7. EGF-ERBB signalling: towards the systems level. Citri A and Yarden Y, Nat Rev Mol Cell Biol. 2006 Jul;7(7):505-16.
8. Interaction of protein tyrosine phosphatase (PTP) 1B with its substrates is influenced by two distinct binding domains. Dadke S and Chernoff J, Biochem J. 2002 Jun 1;364(Pt 2):377-83.
9. Distinct tyrosine autophosphorylation sites negatively and positively modulate neu-mediated transformation. Dankort DL, etal., Mol Cell Biol. 1997 Sep;17(9):5410-25.
10. Effects of age on elements of insulin-signaling pathway in central nervous system of rats. Fernandes ML, etal., Endocrine. 2001 Dec;16(3):227-34.
11. Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins. Fukazawa T, etal., J Biol Chem. 1996 Jun 14;271(24):14554-9.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. The Met tyrosine kinase receptor in development and cancer. Gentile A, etal., Cancer Metastasis Rev. 2008 Mar;27(1):85-94.
14. Grb2-SH3 ligand inhibits the growth of HER2+ cancer cells and has antitumor effects in human cancer xenografts alone and in combination with docetaxel. Gril B, etal., Int J Cancer. 2007 Jul 15;121(2):407-15. doi: 10.1002/ijc.22674.
15. TrkB receptor signalling: implications in neurodegenerative, psychiatric and proliferative disorders. Gupta VK, etal., Int J Mol Sci. 2013 May 13;14(5):10122-42. doi: 10.3390/ijms140510122.
16. Insulin receptor substrate-1/SHP-2 interaction, a phenotype-dependent switching machinery of insulin-like growth factor-I signaling in vascular smooth muscle cells. Hayashi K, etal., J Biol Chem. 2004 Sep 24;279(39):40807-18. Epub 2004 Jul 21.
17. The regulatory subunit of PDE6 interacts with PACSIN in photoreceptors. Houdart F, etal., Mol Vis. 2005 Dec 9;11:1061-70.
18. Phosphorylation of cbl after stimulation of Nb2 cells with prolactin and its association with phosphatidylinositol 3-kinase. Hunter S, etal., Mol Endocrinol. 1997 Aug;11(9):1213-22.
19. Functional importance of Shc tyrosine 317 on insulin signaling in Rat1 fibroblasts expressing insulin receptors. Ishihara H, etal., J Biol Chem. 1997 Apr 4;272(14):9581-6.
20. Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells. Jackman JK, etal., J Biol Chem. 1995 Mar 31;270(13):7029-32.
21. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
22. Insulin signaling through insulin receptor substrate 1 and 2 in normal liver development. Khamzina L, etal., Gastroenterology 2003 Aug;125(2):572-85.
23. Downstream signaling molecules bind to different phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) peptides of the high affinity IgE receptor. Kimura T, etal., J Biol Chem. 1996 Nov 1;271(44):27962-8.
24. Epidermal growth factor-induced phosphatidylinositol 3-kinase activation and DNA synthesis. Identification of Grb2-associated binder 2 as the major mediator in rat hepatocytes. Kong M, etal., J Biol Chem. 2000 Nov 17;275(46):36035-42.
25. Overexpression of MUC1 and Genomic Alterations in Its Network Associate with Prostate Cancer Progression. Lin X, etal., Neoplasia. 2017 Nov;19(11):857-867. doi: 10.1016/j.neo.2017.06.006. Epub 2017 Sep 18.
26. Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130(Cas). Liu F, etal., J Biol Chem. 1996 Dec 6;271(49):31290-5.
27. Direct binding of the signaling adapter protein Grb2 to the activation loop tyrosines on the nerve growth factor receptor tyrosine kinase, TrkA. MacDonald JI, etal., J Biol Chem. 2000 Jun 16;275(24):18225-33.
28. Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries. Matuoka K, etal., Proc Natl Acad Sci U S A 1992 Oct 1;89(19):9015-9.
29. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
30. IL-6/IL-6 receptor system and its role in physiological and pathological conditions. Mihara M, etal., Clin Sci (Lond). 2012 Feb;122(4):143-59. doi: 10.1042/CS20110340.
31. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
32. p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinase. Panchamoorthy G, etal., J Biol Chem. 1996 Feb 9;271(6):3187-94.
33. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
34. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
35. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
36. Shc and CEACAM1 interact to regulate the mitogenic action of insulin. Poy MN, etal., J Biol Chem. 2002 Jan 11;277(2):1076-84. Epub 2001 Nov 1.
37. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
38. Signal transduction through tyrosine-phosphorylated C-terminal fragments of amyloid precursor protein via an enhanced interaction with Shc/Grb2 adaptor proteins in reactive astrocytes of Alzheimer's disease brain. Russo C, etal., J Biol Chem 2002 Sep 20;277(38):35282-8.
39. Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins. Salcini AE, etal., Oncogene. 1994 Oct;9(10):2827-36.
40. The signaling pathway coupling epidermal growth factor receptors to activation of p21ras. Sasaoka T, etal., J Biol Chem. 1994 Dec 23;269(51):32621-5.
41. mDia-interacting protein acts downstream of Rho-mDia and modifies Src activation and stress fiber formation. Satoh S and Tominaga T, J Biol Chem. 2001 Oct 19;276(42):39290-4. Epub 2001 Aug 16.
42. Gene dosage-dependent functions for phosphotyrosine-Grb2 signaling during mammalian tissue morphogenesis. Saxton TM, etal., Curr Biol 2001 May 1;11(9):662-70.
43. DISC1 regulates neurotrophin-induced axon elongation via interaction with Grb2. Shinoda T, etal., J Neurosci. 2007 Jan 3;27(1):4-14.
44. Insulin promotes proliferation, survival, and invasion in endometrial carcinoma by activating the MEK/ERK pathway. Wang Y, etal., Cancer Lett. 2012 Sep 28;322(2):223-31. doi: 10.1016/j.canlet.2012.03.026. Epub 2012 Mar 27.
45. Splicing isoforms of rat Ash/Grb2. Isolation and characterization of the cDNA and genomic DNA clones and implications for the physiological roles of the isoforms. Watanabe K, etal., J Biol Chem 1995 Jun 9;270(23):13733-9.
46. Selection of ligands by panning of domain libraries displayed on phage lambda reveals new potential partners of synaptojanin 1. Zucconi A, etal., J Mol Biol. 2001 Apr 13;307(5):1329-39.
Additional References at PubMed
PMID:7689150   PMID:7953556   PMID:8183574   PMID:8316835   PMID:8388384   PMID:8438166   PMID:8663064   PMID:8889548   PMID:9259551   PMID:9722539   PMID:9918770   PMID:10196222  
PMID:11498538   PMID:11585837   PMID:11877424   PMID:12147689   PMID:12167719   PMID:12218049   PMID:12477932   PMID:12577067   PMID:12837289   PMID:12837295   PMID:12925710   PMID:12960006  
PMID:13679576   PMID:14985334   PMID:15469895   PMID:15488758   PMID:15489334   PMID:15569713   PMID:15736129   PMID:15983387   PMID:16038803   PMID:16908534   PMID:17923684   PMID:18258597  
PMID:19056867   PMID:19509291   PMID:20086093   PMID:20160708   PMID:20398064   PMID:20458337   PMID:20624904   PMID:21179510   PMID:21180072   PMID:22536782   PMID:22561606   PMID:22658674  
PMID:22726438   PMID:22871113   PMID:23376485   PMID:23533145   PMID:23793062   PMID:25650006   PMID:26782545   PMID:28065675   PMID:28235806   PMID:28618656   PMID:32652777  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.210100,881,404 - 100,949,193 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10100,869,718 - 100,949,309 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10105,941,694 - 106,010,414 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010105,404,767 - 105,473,487 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010100,802,375 - 100,870,155 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010104,193,953 - 104,263,071 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10104,193,955 - 104,263,071 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010104,019,823 - 104,087,251 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.010104,735,560 - 104,738,091 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410105,722,014 - 105,818,649 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110105,737,088 - 105,833,269 (-)NCBI
Celera1099,455,840 - 99,524,352 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381775,318,076 - 75,405,678 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1775,318,076 - 75,405,709 (-)EnsemblGRCh38hg38GRCh38
GRCh371773,314,157 - 73,401,759 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361770,825,752 - 70,913,385 (-)NCBINCBI36Build 36hg18NCBI36
Build 341770,825,752 - 70,913,329NCBI
Celera1769,906,645 - 69,994,307 (-)NCBICelera
Cytogenetic Map17q25.1NCBI
HuRef1768,724,752 - 68,824,731 (-)NCBIHuRef
CHM1_11773,378,804 - 73,466,430 (-)NCBICHM1_1
T2T-CHM13v2.01776,210,297 - 76,297,898 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3911115,534,871 - 115,599,423 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11115,534,871 - 115,599,423 (-)EnsemblGRCm39 Ensembl
GRCm3811115,644,045 - 115,708,597 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11115,644,045 - 115,708,597 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711115,505,444 - 115,569,911 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611115,460,220 - 115,524,687 (-)NCBIMGSCv36mm8
Celera11127,412,389 - 127,476,946 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1180.91NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049555532,186,590 - 2,259,456 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555532,186,590 - 2,258,964 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11796,180,874 - 96,268,408 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01769,265,307 - 69,352,835 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11774,817,471 - 74,904,022 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1774,817,471 - 74,903,796 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.195,108,128 - 5,182,091 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl95,117,164 - 5,180,296 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha95,787,497 - 5,861,309 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.095,778,347 - 5,852,258 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl95,778,263 - 5,852,254 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.195,817,381 - 5,891,089 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.095,927,508 - 6,001,301 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.095,988,590 - 6,061,075 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_0244056025,750,590 - 5,819,199 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936594592,740 - 661,369 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936594592,760 - 661,369 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl125,940,647 - 6,010,835 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1125,940,723 - 6,009,095 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2125,860,464 - 5,928,885 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11646,264,818 - 46,346,426 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1646,264,825 - 46,347,156 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607717,032,097 - 17,115,635 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248015,143,141 - 5,219,244 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248015,143,239 - 5,219,136 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Grb2
239 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:248
Count of miRNA genes:146
Interacting mature miRNAs:182
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1090404397107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1090627439107057807Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090627439107211142Rat
1558652Bw57Body weight QTL 574.20.0008body mass (VT:0001259)body weight (CMO:0000012)1090910316107211142Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091228102104060283Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1092238497101012337Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093223816107057807Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
1576307Cia28Collagen induced arthritis QTL 28joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096120911104060283Rat
1576313Pia25Pristane induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096120911104060283Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1096703043107057807Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1096703043107057807Rat
631539Oia6Oil induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1097010147104670812Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210100,882,910 - 100,883,103 (+)MAPPERmRatBN7.2
Rnor_6.010105,068,742 - 105,068,932NCBIRnor6.0
Rnor_6.010104,195,460 - 104,195,652NCBIRnor6.0
Rnor_5.010104,085,552 - 104,085,744UniSTSRnor5.0
Rnor_5.010104,737,067 - 104,737,257UniSTSRnor5.0
RGSC_v3.410105,723,521 - 105,723,713UniSTSRGSC3.4
Celera1099,457,347 - 99,457,539UniSTS
Cytogenetic Map10q32.3UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 43 57 41 19 41 8 11 74 35 40 11 8
Low 1
Below cutoff


RefSeq Acc Id: ENSRNOT00000005347   ⟹   ENSRNOP00000005347
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10100,881,416 - 100,939,377 (-)Ensembl
Rnor_6.0 Ensembl10104,193,955 - 104,263,071 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095127   ⟹   ENSRNOP00000080275
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10100,881,962 - 100,949,309 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111297   ⟹   ENSRNOP00000083430
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10100,869,718 - 100,949,269 (-)Ensembl
RefSeq Acc Id: NM_030846   ⟹   NP_110473
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.210100,881,404 - 100,949,193 (-)NCBI
Rnor_6.010104,193,953 - 104,263,071 (-)NCBI
Rnor_5.010104,735,560 - 104,738,091 (-)NCBI
RGSC_v3.410105,722,014 - 105,818,649 (-)RGD
Celera1099,455,840 - 99,524,352 (-)RGD
RefSeq Acc Id: NP_110473   ⟸   NM_030846
- UniProtKB: Q5BKA7 (UniProtKB/Swiss-Prot),   P62994 (UniProtKB/Swiss-Prot),   A6HKQ4 (UniProtKB/TrEMBL),   A0A8L2Q1H5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000005347   ⟸   ENSRNOT00000005347
RefSeq Acc Id: ENSRNOP00000083430   ⟸   ENSRNOT00000111297
RefSeq Acc Id: ENSRNOP00000080275   ⟸   ENSRNOT00000095127
Protein Domains
SH2   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P62994-F1-model_v2 AlphaFold P62994 1-217 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619758 AgrOrtholog
BIND 129613
BioCyc Gene G2FUF-22660 BioCyc
Ensembl Genes ENSRNOG00000003990 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000005347 ENTREZGENE
  ENSRNOP00000005347.5 UniProtKB/TrEMBL
  ENSRNOP00000080275 UniProtKB/Swiss-Prot
  ENSRNOP00000083430.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005347 ENTREZGENE
  ENSRNOT00000005347.6 UniProtKB/TrEMBL
  ENSRNOT00000095127 UniProtKB/Swiss-Prot
  ENSRNOT00000111297.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 Domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Grb2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GRB2_C_SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GRB2_N_SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81504 UniProtKB/Swiss-Prot
  PTHR46037:SF4 UniProtKB/TrEMBL
Pfam SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Grb2 PhenoGen
PRINTS P67PHOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZZ92_RAT UniProtKB/TrEMBL
UniProt Secondary P29354 UniProtKB/Swiss-Prot
  Q14450 UniProtKB/Swiss-Prot
  Q5BKA7 UniProtKB/Swiss-Prot
  Q63057 UniProtKB/Swiss-Prot
  Q63059 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Grb2  growth factor receptor bound protein 2  LOC103690155  uncharacterized LOC103690155  Data Merged 737654 PROVISIONAL
2014-08-25 LOC103690155  uncharacterized LOC103690155      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-20 Grb2  growth factor receptor bound protein 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Grb2  growth factor receptor bound protein 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_homology mammalian homolog of C. elegans Sem-5 728541