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Gene: Grb2 (growth factor receptor bound protein 2) Rattus norvegicus
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Symbol: Grb2
Name: growth factor receptor bound protein 2
Description: Exhibits several functions, including epidermal growth factor receptor binding activity; insulin receptor substrate binding activity; and phosphotyrosine residue binding activity. Involved in aging. Localizes to protein-containing complex. Human ortholog(s) of this gene implicated in breast cancer; prostate adenocarcinoma; and prostate cancer. Orthologous to human GRB2 (growth factor receptor bound protein 2); PARTICIPATES IN insulin signaling pathway; insulin-like growth factor signaling pathway; brain-derived neurotrophic factor signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: adapter protein GRB2; Ash-psi; growth factor receptor-bound protein 2; MGC108668; protein Ash; SH2/SH3 adapter GRB2
Orthologs:
Homo sapiens (human) : GRB2 (growth factor receptor bound protein 2)  HGNC  Alliance
Mus musculus (house mouse) : Grb2 (growth factor receptor bound protein 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Grb2 (growth factor receptor bound protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : GRB2 (growth factor receptor bound protein 2)
Canis lupus familiaris (dog) : GRB2 (growth factor receptor bound protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grb2 (growth factor receptor bound protein 2)
Sus scrofa (pig) : GRB2 (growth factor receptor bound protein 2)
Chlorocebus sabaeus (African green monkey) : GRB2 (growth factor receptor bound protein 2)
Heterocephalus glaber (naked mole-rat) : Grb2 (growth factor receptor bound protein 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.010104,193,953 - 104,263,071 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10104,193,955 - 104,263,071 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010104,735,560 - 104,738,091 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.010104,019,823 - 104,087,251 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410105,722,014 - 105,818,649 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.110105,737,088 - 105,833,269 (-)NCBI
Celera1099,455,840 - 99,524,352 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
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Genomics

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RNA-SEQ Expression

Sequence

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Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

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Nomenclature History
RGD Curation Notes
  
More on Grb2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 619758
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.