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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-Tetrandrine | decreases expression | ISO | RGD:732473 | 6480464 | tetrandrine results in decreased expression of GRB2 protein | CTD | PMID:30549224 | 1,2-dimethylhydrazine | decreases expression | EXP | | 6480464 | 1, 2-Dimethylhydrazine results in decreased expression of GRB2 mRNA | CTD | PMID:32387197 | 1,2-dimethylhydrazine | multiple interactions | ISO | RGD:732474 | 6480464 | [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of GRB2 mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | decreases expression | ISO | RGD:732474 | 6480464 | 1, 2-Dimethylhydrazine results in decreased expression of GRB2 mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:732474 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GRB2 mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | increases expression | ISO | RGD:732474 | 6480464 | Ethinyl Estradiol results in increased expression of GRB2 mRNA | CTD | PMID:17942748 | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of GRB2 mRNA, [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of GRB2 protein | CTD | PMID:22465879 | 17beta-estradiol | multiple interactions | ISO | RGD:732473 | 6480464 | IGF1R mutant form inhibits the reaction [Estradiol results in increased expression of GRB2 mRNA] | CTD | PMID:23094148 | 17beta-estradiol | increases expression | ISO | RGD:732473 | 6480464 | Estradiol results in increased expression of GRB2 mRNA | CTD | PMID:23094148 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:732474 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GRB2 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | CBL protein promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [GRB2 protein binds to SOS1 protein]] more ... | CTD | PMID:9918770 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:732474 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of GRB2 mRNA | CTD | PMID:19465110, PMID:22666406 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:732474 | 6480464 | Tetrachlorodibenzodioxin affects the expression of GRB2 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of GRB2 mRNA | CTD | PMID:22298810, PMID:34747641 | 3-chloropropane-1,2-diol | decreases expression | EXP | | 6480464 | alpha-Chlorohydrin analog results in decreased expression of GRB2 protein | CTD | PMID:26597043 | 4-hydroxyphenyl retinamide | increases expression | ISO | RGD:732473 | 6480464 | Fenretinide results in increased expression of GRB2 protein | CTD | PMID:15059897 | aflatoxin B1 | increases methylation | ISO | RGD:732473 | 6480464 | Aflatoxin B1 results in increased methylation of GRB2 intron | CTD | PMID:30157460 | Aflatoxin B2 alpha | decreases methylation | ISO | RGD:732473 | 6480464 | aflatoxin B2 results in decreased methylation of GRB2 intron | CTD | PMID:30157460 | AICA ribonucleotide | multiple interactions | EXP | | 6480464 | GRB2 protein affects the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein] | CTD | PMID:11978788 | all-trans-retinoic acid | increases expression | ISO | RGD:732473 | 6480464 | Tretinoin results in increased expression of GRB2 mRNA | CTD | PMID:33167477 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of GRB2 mRNA | CTD | PMID:16483693 | ammonium chloride | decreases expression | EXP | | 6480464 | Ammonium Chloride results in decreased expression of GRB2 protein | CTD | PMID:16483693 | antirheumatic drug | decreases expression | ISO | RGD:732473 | 6480464 | Antirheumatic Agents results in decreased expression of GRB2 mRNA | CTD | PMID:24449571 | arsenic acid | multiple interactions | ISO | RGD:732473 | 6480464 | arsenic acid promotes the reaction [SHC1 protein binds to GRB2 protein] | CTD | PMID:14674888 | arsenite(3-) | multiple interactions | ISO | RGD:732473 | 6480464 | arsenite promotes the reaction [SHC1 protein binds to GRB2 protein] | CTD | PMID:14674888 | arsenous acid | decreases expression | ISO | RGD:732473 | 6480464 | Arsenic Trioxide results in decreased expression of GRB2 protein | CTD | PMID:25419056 | arsenous acid | increases expression | ISO | RGD:732473 | 6480464 | Arsenic Trioxide results in increased expression of GRB2 mRNA | CTD | PMID:20458559 | Benoxacor | decreases expression | ISO | RGD:732474 | 6480464 | benoxacor results in decreased expression of GRB2 mRNA | CTD | PMID:34850242 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of GRB2 protein | CTD | PMID:21467743 | benzo[a]pyrene | affects methylation | ISO | RGD:732473 | 6480464 | Benzo(a)pyrene affects the methylation of GRB2 intron | CTD | PMID:30157460 | benzo[e]pyrene | decreases methylation | ISO | RGD:732473 | 6480464 | benzo(e)pyrene results in decreased methylation of GRB2 intron | CTD | PMID:30157460 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of GRB2 mRNA | CTD | PMID:25181051, PMID:34947998 | bisphenol A | multiple interactions | ISO | RGD:732473 | 6480464 | ESR1 protein affects the reaction [bisphenol A results in increased expression of GRB2 protein] | CTD | PMID:30615907 | bisphenol A | increases expression | ISO | RGD:732473 | 6480464 | bisphenol A results in increased expression of GRB2 protein | CTD | PMID:30615907 | bufalin | decreases expression | ISO | RGD:732473 | 6480464 | bufalin results in decreased expression of GRB2 protein | CTD | PMID:23949904 | cadmium atom | increases expression | ISO | RGD:732473 | 6480464 | Cadmium results in increased expression of GRB2 protein | CTD | PMID:14499349 | cadmium dichloride | affects expression | ISO | RGD:732473 | 6480464 | Cadmium Chloride affects the expression of GRB2 mRNA | CTD | PMID:33129824 | calcitriol | increases expression | ISO | RGD:732473 | 6480464 | Calcitriol results in increased expression of GRB2 mRNA | CTD | PMID:15951637 | cannabidiol | multiple interactions | ISO | RGD:732473 | 6480464 | [Cannabidiol co-treated with moringin] results in increased expression of GRB2 mRNA, [Oxygen co-treated with Ozone co-treated with Cannabidiol] results in decreased expression of GRB2 mRNA | CTD | PMID:30096889, PMID:32992648 | casticin | decreases expression | ISO | RGD:732474 | 6480464 | casticin results in decreased expression of GRB2 protein | CTD | PMID:28444820 | cerium trichloride | affects expression | ISO | RGD:732474 | 6480464 | cerous chloride affects the expression of GRB2 mRNA | CTD | PMID:23139204 | chlordecone | decreases expression | ISO | RGD:732474 | 6480464 | Chlordecone results in decreased expression of GRB2 mRNA | CTD | PMID:29980752 | chlorpyrifos | increases expression | ISO | RGD:732474 | 6480464 | Chlorpyrifos results in increased expression of GRB2 mRNA | CTD | PMID:27737797 | choline | multiple interactions | EXP | | 6480464 | [Folic Acid deficiency co-treated with Methionine deficiency co-treated with Choline deficiency] results in increased expression of GRB2 protein | CTD | PMID:19566968 | chrysin | decreases expression | ISO | RGD:732473 | 6480464 | chrysin results in decreased expression of GRB2 protein | CTD | PMID:30578657 | clofibrate | decreases expression | ISO | RGD:732474 | 6480464 | Clofibrate results in decreased expression of GRB2 mRNA | CTD | PMID:23811191 | cobalt dichloride | increases expression | ISO | RGD:732473 | 6480464 | cobaltous chloride results in increased expression of GRB2 mRNA | CTD | PMID:19376846 | cocaine | increases expression | EXP | | 6480464 | Cocaine results in increased expression of GRB2 protein | CTD | PMID:25100957 | copper(II) sulfate | increases expression | ISO | RGD:732473 | 6480464 | Copper Sulfate results in increased expression of GRB2 mRNA | CTD | PMID:19549813 | crocidolite asbestos | affects expression | ISO | RGD:732473 | 6480464 | Asbestos, Crocidolite affects the expression of GRB2 mRNA | CTD | PMID:17331233 | curcumin | decreases expression | ISO | RGD:732473 | 6480464 | Curcumin analog results in decreased expression of GRB2 mRNA | CTD | PMID:26409325 | cypermethrin | decreases expression | ISO | RGD:732473 | 6480464 | cypermethrin results in decreased expression of GRB2 mRNA | CTD | PMID:27704156 | DDT | multiple interactions | ISO | RGD:732473 | 6480464 | DDT promotes the reaction [GRB2 protein binds to SOS1 protein] | CTD | PMID:9070211 | decabromodiphenyl ether | increases expression | EXP | | 6480464 | decabromobiphenyl ether results in increased expression of GRB2 mRNA | CTD | PMID:23640034 | dexamethasone | multiple interactions | ISO | RGD:732473 | 6480464 | Dexamethasone inhibits the reaction [EGF protein promotes the reaction [EGFR protein binds to GRB2 protein]], Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [EGF protein promotes the reaction [EGFR protein binds to GRB2 protein]]] | CTD | PMID:10807665 | dextran sulfate | multiple interactions | ISO | RGD:732474 | 6480464 | [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of GRB2 mRNA | CTD | PMID:29950665 | diallyl disulfide | affects expression | ISO | RGD:732473 | 6480464 | diallyl disulfide affects the expression of GRB2 protein | CTD | PMID:21695758 | diallyl disulfide | decreases expression | ISO | RGD:732473 | 6480464 | diallyl disulfide results in decreased expression of GRB2 protein | CTD | PMID:21695758 | Diallyl sulfide | decreases expression | ISO | RGD:732473 | 6480464 | allyl sulfide results in decreased expression of GRB2 protein | CTD | PMID:21695758 | diarsenic trioxide | decreases expression | ISO | RGD:732473 | 6480464 | Arsenic Trioxide results in decreased expression of GRB2 protein | CTD | PMID:25419056 | diarsenic trioxide | increases expression | ISO | RGD:732473 | 6480464 | Arsenic Trioxide results in increased expression of GRB2 mRNA | CTD | PMID:20458559 | dioxygen | multiple interactions | ISO | RGD:732473 | 6480464 | [Oxygen co-treated with Ozone co-treated with Cannabidiol] results in decreased expression of GRB2 mRNA, [Oxygen co-treated with Ozone] results in decreased expression of GRB2 mRNA | CTD | PMID:32992648 | disodium selenite | decreases expression | ISO | RGD:732473 | 6480464 | Sodium Selenite results in decreased expression of GRB2 mRNA | CTD | PMID:16705456 | disodium selenite | increases expression | ISO | RGD:732473 | 6480464 | Sodium Selenite results in increased expression of GRB2 mRNA | CTD | PMID:18175754 | enzyme inhibitor | multiple interactions | ISO | RGD:732473 | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of GRB2 protein | CTD | PMID:23301498 | ethanol | affects splicing | ISO | RGD:732474 | 6480464 | Ethanol affects the splicing of GRB2 mRNA | CTD | PMID:30319688 | finasteride | increases expression | EXP | | 6480464 | Finasteride results in increased expression of GRB2 mRNA | CTD | PMID:24136188 | flavonoids | increases expression | EXP | | 6480464 | Flavonoids results in increased expression of GRB2 mRNA | CTD | PMID:18035473 | folic acid | multiple interactions | EXP | | 6480464 | [Folic Acid deficiency co-treated with Methionine deficiency co-treated with Choline deficiency] results in increased expression of GRB2 protein | CTD | PMID:19566968 | folic acid | multiple interactions | ISO | RGD:732474 | 6480464 | [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of GRB2 mRNA | CTD | PMID:22206623 | gallic acid | decreases expression | ISO | RGD:732473 | 6480464 | Gallic Acid results in decreased expression of GRB2 protein | CTD | PMID:22387266 | genistein | decreases expression | ISO | RGD:732473 | 6480464 | Genistein results in decreased expression of GRB2 mRNA | CTD | PMID:16705744 | genistein | increases expression | ISO | RGD:732473 | 6480464 | Genistein results in increased expression of GRB2 mRNA | CTD | PMID:20884965 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of GRB2 mRNA | CTD | PMID:22061828 | glyphosate | decreases expression | ISO | RGD:732473 | 6480464 | glyphosate results in decreased expression of GRB2 mRNA | CTD | PMID:31295307 | hydrogen peroxide | affects expression | ISO | RGD:732473 | 6480464 | Hydrogen Peroxide affects the expression of GRB2 mRNA | CTD | PMID:21179406 | hydroquinone | affects expression | ISO | RGD:732473 | 6480464 | hydroquinone affects the expression of GRB2 protein | CTD | PMID:20021034 | ivermectin | decreases expression | ISO | RGD:732473 | 6480464 | Ivermectin results in decreased expression of GRB2 protein | CTD | PMID:32959892 | L-methionine | multiple interactions | EXP | | 6480464 | [Folic Acid deficiency co-treated with Methionine deficiency co-treated with Choline deficiency] results in increased expression of GRB2 protein | CTD | PMID:19566968 | letrozole | increases expression | ISO | RGD:732474 | 6480464 | letrozole results in increased expression of GRB2 protein | CTD | PMID:15967659 | maneb | multiple interactions | ISO | RGD:732474 | 6480464 | [Maneb co-treated with Paraquat] results in decreased expression of GRB2 mRNA more ... | CTD | PMID:23963992 | melatonin | multiple interactions | ISO | RGD:732474 | 6480464 | Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of GRB2 mRNA] | CTD | PMID:23963992 | methamphetamine | affects expression | EXP | | 6480464 | Methamphetamine affects the expression of GRB2 protein | CTD | PMID:17904249 | methapyrilene | decreases methylation | ISO | RGD:732473 | 6480464 | Methapyrilene results in decreased methylation of GRB2 intron | CTD | PMID:30157460 | microcystin | decreases expression | EXP | | 6480464 | Microcystins results in decreased expression of GRB2 protein | CTD | PMID:22430071 | mifepristone | multiple interactions | ISO | RGD:732473 | 6480464 | Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [EGF protein promotes the reaction [EGFR protein binds to GRB2 protein]]] | CTD | PMID:10807665 | N-methyl-N-nitrosourea | multiple interactions | EXP | | 6480464 | [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of GRB2 mRNA, [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of GRB2 protein | CTD | PMID:22465879 | nickel atom | increases expression | ISO | RGD:732473 | 6480464 | Nickel results in increased expression of GRB2 mRNA | CTD | PMID:24768652, PMID:25583101 | nitric oxide | decreases expression | ISO | RGD:732474 | 6480464 | Nitric Oxide deficiency results in decreased expression of GRB2 mRNA | CTD | PMID:15878706 | Nonidet P-40 | decreases expression | ISO | RGD:732473 | 6480464 | Nonidet P-40 results in decreased expression of GRB2 mRNA | CTD | PMID:26552463 | ouabain | decreases expression | ISO | RGD:732473 | 6480464 | Ouabain results in decreased expression of GRB2 protein | CTD | PMID:28795476 | ozone | multiple interactions | ISO | RGD:732473 | 6480464 | [Oxygen co-treated with Ozone co-treated with Cannabidiol] results in decreased expression of GRB2 mRNA, [Oxygen co-treated with Ozone] results in decreased expression of GRB2 mRNA | CTD | PMID:32992648 | ozone | increases expression | EXP | | 6480464 | Ozone results in increased expression of GRB2 protein | CTD | PMID:33146391 | p-menthan-3-ol | decreases expression | ISO | RGD:732473 | 6480464 | Menthol results in decreased expression of GRB2 mRNA | CTD | PMID:26760959 | paracetamol | affects expression | ISO | RGD:732474 | 6480464 | Acetaminophen affects the expression of GRB2 mRNA | CTD | PMID:17562736 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of GRB2 mRNA | CTD | PMID:16701773 | paraquat | multiple interactions | ISO | RGD:732474 | 6480464 | [Maneb co-treated with Paraquat] results in decreased expression of GRB2 mRNA more ... | CTD | PMID:23963992 | perfluorooctanoic acid | decreases expression | EXP | | 6480464 | perfluorooctanoic acid results in decreased expression of GRB2 mRNA | CTD | PMID:19162173 | phenylarsine oxide | multiple interactions | EXP | | 6480464 | [oxophenylarsine results in decreased phosphorylation of PLCG1 protein] inhibits the reaction [PLCG1 protein binds to GRB2 protein] | CTD | PMID:9281317 | phosphane | decreases expression | EXP | | 6480464 | phosphine results in decreased expression of GRB2 mRNA | CTD | PMID:34427094 | pirinixic acid | decreases expression | ISO | RGD:732474 | 6480464 | pirinixic acid results in decreased expression of GRB2 mRNA | CTD | PMID:23811191 | pregnenolone 16alpha-carbonitrile | increases expression | ISO | RGD:732474 | 6480464 | Pregnenolone Carbonitrile results in increased expression of GRB2 mRNA | CTD | PMID:28903501 | progesterone | multiple interactions | EXP | | 6480464 | [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of GRB2 mRNA, [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of GRB2 protein | CTD | PMID:22465879 | propiconazole | decreases expression | ISO | RGD:732474 | 6480464 | propiconazole results in decreased expression of GRB2 mRNA | CTD | PMID:21278054 | quercetin | increases expression | ISO | RGD:732473 | 6480464 | Quercetin results in increased expression of GRB2 mRNA | CTD | PMID:27514524 | quercetin | decreases expression | ISO | RGD:732473 | 6480464 | Quercetin results in decreased expression of GRB2 protein | CTD | PMID:23645742 | resveratrol | decreases expression | ISO | RGD:732473 | 6480464 | resveratrol results in decreased expression of GRB2 mRNA | CTD | PMID:12002526 | resveratrol | multiple interactions | ISO | RGD:732473 | 6480464 | resveratrol promotes the reaction [[ITGAV protein binds to ITGB3 protein] which affects the localization of GRB2 protein] | CTD | PMID:21467134 | S-butyl-DL-homocysteine (S,R)-sulfoximine | decreases expression | ISO | RGD:732474 | 6480464 | Buthionine Sulfoximine results in decreased expression of GRB2 mRNA | CTD | PMID:15878706 | sodium arsenite | increases expression | ISO | RGD:732473 | 6480464 | sodium arsenite results in increased expression of GRB2 mRNA | CTD | PMID:12016162, PMID:34032870 | sodium arsenite | decreases expression | ISO | RGD:732473 | 6480464 | sodium arsenite results in decreased expression of GRB2 protein | CTD | PMID:30528433 | sodium arsenite | multiple interactions | EXP | | 6480464 | [sodium arsenite results in increased phosphorylation of SHC1 protein] promotes the reaction [SHC1 protein modified form binds to GRB2 protein], sodium arsenite promotes the reaction [SHC1 protein modified form binds to GRB2 protein] | CTD | PMID:9710602 | sorafenib | decreases expression | ISO | RGD:732473 | 6480464 | sorafenib results in decreased expression of GRB2 mRNA | CTD | PMID:26409325 | sulindac | increases expression | EXP | | 6480464 | Sulindac results in increased expression of GRB2 mRNA | CTD | PMID:24136188 | tert-butyl hydroperoxide | increases expression | ISO | RGD:732473 | 6480464 | tert-Butylhydroperoxide results in increased expression of GRB2 mRNA | CTD | PMID:15336504 | titanium dioxide | multiple interactions | ISO | RGD:732474 | 6480464 | [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of GRB2 mRNA | CTD | PMID:29950665 | trimethyltin | increases expression | ISO | RGD:732474 | 6480464 | trimethyltin results in increased expression of GRB2 mRNA | CTD | PMID:20833246 | Triptolide | decreases expression | ISO | RGD:732474 | 6480464 | triptolide results in decreased expression of GRB2 protein | CTD | PMID:26420756 | uranium atom | affects expression | ISO | RGD:732473 | 6480464 | Uranium affects the expression of GRB2 mRNA | CTD | PMID:15672453 | valproic acid | increases expression | ISO | RGD:732473 | 6480464 | Valproic Acid results in increased expression of GRB2 mRNA | CTD | PMID:23179753 | |