Grb2 (growth factor receptor bound protein 2) - Rat Genome Database

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Gene: Grb2 (growth factor receptor bound protein 2) Rattus norvegicus
Analyze
Symbol: Grb2
Name: growth factor receptor bound protein 2
RGD ID: 619758
Description: Enables several functions, including epidermal growth factor receptor binding activity; insulin receptor substrate binding activity; and phosphotyrosine residue binding activity. Involved in aging. Part of protein-containing complex. Human ortholog(s) of this gene implicated in breast cancer; prostate adenocarcinoma; and prostate cancer. Orthologous to human GRB2 (growth factor receptor bound protein 2); PARTICIPATES IN insulin signaling pathway; insulin-like growth factor signaling pathway; brain-derived neurotrophic factor signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adapter protein GRB2; Ash-psi; growth factor receptor-bound protein 2; growth factor receptor-bound protein 2-like; LOC103690155; MGC108668; protein Ash; SH2/SH3 adapter GRB2; uncharacterized LOC103690155
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.210100,881,404 - 100,949,193 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl10100,869,718 - 100,949,309 (-)Ensembl
Rnor_6.010104,193,953 - 104,263,071 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10104,193,955 - 104,263,071 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010104,735,560 - 104,738,091 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.010104,019,823 - 104,087,251 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410105,722,014 - 105,818,649 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.110105,737,088 - 105,833,269 (-)NCBI
Celera1099,455,840 - 99,524,352 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Tetrandrine  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-chloropropane-1,2-diol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
AICA ribonucleotide  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsenic acid  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
Benoxacor  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bufalin  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
casticin  (ISO)
cerium trichloride  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
choline  (EXP)
chrysin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cypermethrin  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diarsenic trioxide  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
finasteride  (EXP)
flavonoids  (EXP)
folic acid  (EXP,ISO)
gallic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
ivermectin  (ISO)
L-methionine  (EXP)
letrozole  (ISO)
maneb  (ISO)
melatonin  (ISO)
methamphetamine  (EXP)
methapyrilene  (ISO)
microcystin  (EXP)
mifepristone  (ISO)
N-methyl-N-nitrosourea  (EXP)
nickel atom  (ISO)
nitric oxide  (ISO)
Nonidet P-40  (ISO)
ouabain  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctanoic acid  (EXP)
phenylarsine oxide  (EXP)
phosphane  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP)
propiconazole  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
sodium arsenite  (EXP,ISO)
sorafenib  (ISO)
sulindac  (EXP)
tert-butyl hydroperoxide  (ISO)
titanium dioxide  (ISO)
trimethyltin  (ISO)
Triptolide  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell-cell junction  (ISO)
COP9 signalosome  (IBA,ISO,ISS)
cytoplasm  (IBA,ISO,ISS)
cytosol  (TAS)
endosome  (ISO,ISS)
Golgi apparatus  (IEA)
Grb2-EGFR complex  (ISO)
membrane  (ISO)
nucleolus  (IEA,ISO)
nucleoplasm  (IBA,ISO)
nucleus  (ISO,ISS)
plasma membrane  (IBA,ISO)
protein-containing complex  (IDA)
vesicle membrane  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
acute myeloid leukemia pathway  (IEA)
B cell receptor signaling pathway  (IEA)
brain-derived neurotrophic factor signaling pathway  (ISO)
chemokine mediated signaling pathway  (IEA)
chronic myeloid leukemia pathway  (IEA)
endometrial cancer pathway  (IEA)
ephrin - ephrin receptor bidirectional signaling axis  (ISO)
epidermal growth factor/neuregulin signaling pathway  (IEA,ISO)
erythropoietin signaling pathway  (ISO)
Fc epsilon receptor mediated signaling pathway  (IEA,ISO)
fibroblast growth factor signaling pathway  (ISO)
glioma pathway  (IEA)
gonadotropin-releasing hormone signaling pathway  (IEA)
granulocyte-macrophage colony-stimulating factor signaling pathway  (ISO)
hepatitis C pathway  (IEA)
insulin signaling pathway  (IDA,IEA,ISO)
insulin-like growth factor signaling pathway  (IMP,ISO)
interleukin-2 signaling pathway  (ISO)
interleukin-3 signaling pathway  (ISO)
interleukin-4 signaling pathway  (ISO)
interleukin-5 signaling pathway  (ISO)
interleukin-6 signaling pathway  (ISO)
Jak-Stat signaling pathway  (IEA)
mitogen activated protein kinase signaling pathway  (IEA)
neurotrophic factor signaling pathway  (IEA)
non-small cell lung carcinoma pathway  (IEA)
platelet-derived growth factor signaling pathway  (ISO)
prostate cancer pathway  (IEA)
renal cell carcinoma pathway  (IEA)
scatter factor/hepatocyte growth factor signaling pathway  (ISO)
T cell receptor signaling pathway  (IEA)
transforming growth factor-beta Smad dependent signaling pathway  (ISO)
vascular endothelial growth factor signaling pathway  (ISO)

References

References - curated
1. Ahmed Z, etal., Nat Commun. 2015 Jun 24;6:7354. doi: 10.1038/ncomms8354.
2. Anggono V and Robinson PJ, J Neurochem. 2007 Aug;102(3):931-43. Epub 2007 Apr 16.
3. Birchmeier C, etal., Nat Rev Mol Cell Biol. 2003 Dec;4(12):915-25.
4. Chadwick W, etal., J Signal Transuct. 2011;2011. pii: 636951.
5. Cheng AM, etal., Cell 1998 Dec 11;95(6):793-803.
6. Chu J, etal., Blood. 1998 Sep 1;92(5):1697-706.
7. Citri A and Yarden Y, Nat Rev Mol Cell Biol. 2006 Jul;7(7):505-16.
8. Dadke S and Chernoff J, Biochem J. 2002 Jun 1;364(Pt 2):377-83.
9. Dankort DL, etal., Mol Cell Biol. 1997 Sep;17(9):5410-25.
10. Fernandes ML, etal., Endocrine. 2001 Dec;16(3):227-34.
11. Fukazawa T, etal., J Biol Chem. 1996 Jun 14;271(24):14554-9.
12. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Gentile A, etal., Cancer Metastasis Rev. 2008 Mar;27(1):85-94.
14. Gril B, etal., Int J Cancer. 2007 Jul 15;121(2):407-15. doi: 10.1002/ijc.22674.
15. Gupta VK, etal., Int J Mol Sci. 2013 May 13;14(5):10122-42. doi: 10.3390/ijms140510122.
16. Hayashi K, etal., J Biol Chem. 2004 Sep 24;279(39):40807-18. Epub 2004 Jul 21.
17. Houdart F, etal., Mol Vis. 2005 Dec 9;11:1061-70.
18. Hunter S, etal., Mol Endocrinol. 1997 Aug;11(9):1213-22.
19. Ishihara H, etal., J Biol Chem. 1997 Apr 4;272(14):9581-6.
20. Jackman JK, etal., J Biol Chem. 1995 Mar 31;270(13):7029-32.
21. KEGG
22. Khamzina L, etal., Gastroenterology 2003 Aug;125(2):572-85.
23. Kimura T, etal., J Biol Chem. 1996 Nov 1;271(44):27962-8.
24. Kong M, etal., J Biol Chem. 2000 Nov 17;275(46):36035-42.
25. Lin X, etal., Neoplasia. 2017 Nov;19(11):857-867. doi: 10.1016/j.neo.2017.06.006. Epub 2017 Sep 18.
26. Liu F, etal., J Biol Chem. 1996 Dec 6;271(49):31290-5.
27. MacDonald JI, etal., J Biol Chem. 2000 Jun 16;275(24):18225-33.
28. Matuoka K, etal., Proc Natl Acad Sci U S A 1992 Oct 1;89(19):9015-9.
29. MGD data from the GO Consortium
30. Mihara M, etal., Clin Sci (Lond). 2012 Feb;122(4):143-59. doi: 10.1042/CS20110340.
31. NCBI rat LocusLink and RefSeq merged data July 26, 2002
32. Panchamoorthy G, etal., J Biol Chem. 1996 Feb 9;271(6):3187-94.
33. Pipeline to import KEGG annotations from KEGG into RGD
34. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
35. Pipeline to import SMPDB annotations from SMPDB into RGD
36. Poy MN, etal., J Biol Chem. 2002 Jan 11;277(2):1076-84. Epub 2001 Nov 1.
37. RGD automated import pipeline for gene-chemical interactions
38. Russo C, etal., J Biol Chem 2002 Sep 20;277(38):35282-8.
39. Salcini AE, etal., Oncogene. 1994 Oct;9(10):2827-36.
40. Sasaoka T, etal., J Biol Chem. 1994 Dec 23;269(51):32621-5.
41. Satoh S and Tominaga T, J Biol Chem. 2001 Oct 19;276(42):39290-4. Epub 2001 Aug 16.
42. Saxton TM, etal., Curr Biol 2001 May 1;11(9):662-70.
43. Shinoda T, etal., J Neurosci. 2007 Jan 3;27(1):4-14.
44. Wang Y, etal., Cancer Lett. 2012 Sep 28;322(2):223-31. doi: 10.1016/j.canlet.2012.03.026. Epub 2012 Mar 27.
45. Watanabe K, etal., J Biol Chem 1995 Jun 9;270(23):13733-9.
46. Zucconi A, etal., J Mol Biol. 2001 Apr 13;307(5):1329-39.
Additional References at PubMed
PMID:7689150   PMID:7953556   PMID:8183574   PMID:8316835   PMID:8388384   PMID:8438166   PMID:8663064   PMID:8889548   PMID:9259551   PMID:9722539   PMID:9918770   PMID:10196222  
PMID:11498538   PMID:11585837   PMID:11877424   PMID:12147689   PMID:12167719   PMID:12218049   PMID:12477932   PMID:12577067   PMID:12837289   PMID:12837295   PMID:12925710   PMID:12960006  
PMID:13679576   PMID:14985334   PMID:15469895   PMID:15488758   PMID:15489334   PMID:15569713   PMID:15736129   PMID:15983387   PMID:16038803   PMID:16908534   PMID:17923684   PMID:18258597  
PMID:19056867   PMID:19509291   PMID:20086093   PMID:20160708   PMID:20398064   PMID:20458337   PMID:20624904   PMID:21179510   PMID:21180072   PMID:22536782   PMID:22561606   PMID:22658674  
PMID:22726438   PMID:22871113   PMID:23376485   PMID:23533145   PMID:23793062   PMID:25650006   PMID:26782545   PMID:28065675   PMID:28235806   PMID:28618656   PMID:32652777  


Genomics

Comparative Map Data
Grb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.210100,881,404 - 100,949,193 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl10100,869,718 - 100,949,309 (-)Ensembl
Rnor_6.010104,193,953 - 104,263,071 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10104,193,955 - 104,263,071 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010104,735,560 - 104,738,091 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.010104,019,823 - 104,087,251 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410105,722,014 - 105,818,649 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.110105,737,088 - 105,833,269 (-)NCBI
Celera1099,455,840 - 99,524,352 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
GRB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381775,318,076 - 75,405,678 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1775,318,076 - 75,405,709 (-)EnsemblGRCh38hg38GRCh38
GRCh371773,314,157 - 73,401,759 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361770,825,752 - 70,913,385 (-)NCBINCBI36hg18NCBI36
Build 341770,825,752 - 70,913,329NCBI
Celera1769,906,645 - 69,994,307 (-)NCBI
Cytogenetic Map17q25.1NCBI
HuRef1768,724,752 - 68,824,731 (-)NCBIHuRef
CHM1_11773,378,804 - 73,466,430 (-)NCBICHM1_1
Grb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911115,534,871 - 115,599,423 (-)NCBIGRCm39mm39
GRCm39 Ensembl11115,534,871 - 115,599,423 (-)Ensembl
GRCm3811115,644,045 - 115,708,597 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11115,644,045 - 115,708,597 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711115,505,444 - 115,569,911 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611115,460,220 - 115,524,687 (-)NCBImm8
Celera11127,412,389 - 127,476,946 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1180.91NCBI
Grb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555532,186,590 - 2,259,456 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555532,186,590 - 2,258,964 (-)NCBIChiLan1.0ChiLan1.0
GRB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11774,817,471 - 74,904,022 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1774,817,471 - 74,903,796 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01769,265,307 - 69,352,835 (-)NCBIMhudiblu_PPA_v0panPan3
GRB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.195,108,128 - 5,182,091 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl95,117,164 - 5,180,296 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha95,787,497 - 5,861,309 (+)NCBI
ROS_Cfam_1.095,778,347 - 5,852,258 (+)NCBI
ROS_Cfam_1.0 Ensembl95,778,263 - 5,852,254 (+)Ensembl
UMICH_Zoey_3.195,817,381 - 5,891,089 (+)NCBI
UNSW_CanFamBas_1.095,927,508 - 6,001,301 (+)NCBI
UU_Cfam_GSD_1.095,988,590 - 6,061,075 (+)NCBI
Grb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056025,750,590 - 5,819,199 (+)NCBI
SpeTri2.0NW_004936594592,760 - 661,369 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl125,940,647 - 6,010,835 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1125,940,723 - 6,009,095 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2125,860,464 - 5,928,885 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GRB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11646,264,818 - 46,346,426 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1646,264,825 - 46,347,156 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607717,032,097 - 17,115,635 (+)NCBIVero_WHO_p1.0
Grb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248015,143,239 - 5,219,136 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH133824  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210100,882,910 - 100,883,103 (+)MAPPERmRatBN7.2
Rnor_6.010105,068,742 - 105,068,932NCBIRnor6.0
Rnor_6.010104,195,460 - 104,195,652NCBIRnor6.0
Rnor_5.010104,085,552 - 104,085,744UniSTSRnor5.0
Rnor_5.010104,737,067 - 104,737,257UniSTSRnor5.0
RGSC_v3.410105,723,521 - 105,723,713UniSTSRGSC3.4
Celera1099,457,347 - 99,457,539UniSTS
Cytogenetic Map10q32.3UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1090404397107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1090627439107057807Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090627439107211142Rat
1558652Bw57Body weight QTL 574.20.0008body mass (VT:0001259)body weight (CMO:0000012)1090910316107211142Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091228102104060283Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1092238497101012337Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093223816107057807Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
1576307Cia28Collagen induced arthritis QTL 28joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096120911104060283Rat
1576313Pia25Pristane induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096120911104060283Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1096703043107057807Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)1096703043107057807Rat
631539Oia6Oil induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1097010147104670812Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:248
Count of miRNA genes:146
Interacting mature miRNAs:182
Transcripts:ENSRNOT00000005347
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 40 11 8
Low 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000005347   ⟹   ENSRNOP00000005347
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10100,881,416 - 100,939,377 (-)Ensembl
Rnor_6.0 Ensembl10104,193,955 - 104,263,071 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095127   ⟹   ENSRNOP00000080275
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10100,881,962 - 100,949,309 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111297   ⟹   ENSRNOP00000083430
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10100,869,718 - 100,949,269 (-)Ensembl
RefSeq Acc Id: NM_030846   ⟹   NP_110473
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.210100,881,404 - 100,949,193 (-)NCBI
Rnor_6.010104,193,953 - 104,263,071 (-)NCBI
Rnor_5.010104,735,560 - 104,738,091 (-)NCBI
RGSC_v3.410105,722,014 - 105,818,649 (-)RGD
Celera1099,455,840 - 99,524,352 (-)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_110473   ⟸   NM_030846
- UniProtKB: P62994 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000005347   ⟸   ENSRNOT00000005347
RefSeq Acc Id: ENSRNOP00000083430   ⟸   ENSRNOT00000111297
RefSeq Acc Id: ENSRNOP00000080275   ⟸   ENSRNOT00000095127
Protein Domains
SH2   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P62994-F1-model_v2 AlphaFold P62994 1-217 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697894
Promoter ID:EPDNEW_R8418
Type:initiation region
Name:Grb2_1
Description:growth factor receptor bound protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.010104,263,169 - 104,263,229EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619758 AgrOrtholog
BIND 129613
  129614
  129615
  129616
  134462
BioCyc Gene G2FUF-22660 BioCyc
Ensembl Genes ENSRNOG00000003990 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000005347 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005347 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7382476 IMAGE-MGC_LOAD
InterPro GRB2_C_SH3 UniProtKB/Swiss-Prot
  GRB2_N_SH3 UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH2_dom_sf UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
KEGG Report rno:81504 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108668 IMAGE-MGC_LOAD
NCBI Gene 81504 ENTREZGENE
Pfam SH2 UniProtKB/Swiss-Prot
  SH3_1 UniProtKB/Swiss-Prot
PhenoGen Grb2 PhenoGen
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot
  SH3DOMAIN UniProtKB/Swiss-Prot
PROSITE SH2 UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
SMART SH2 UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot
  SSF55550 UniProtKB/Swiss-Prot
UniProt GRB2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P29354 UniProtKB/Swiss-Prot
  Q14450 UniProtKB/Swiss-Prot
  Q5BKA7 UniProtKB/Swiss-Prot
  Q63057 UniProtKB/Swiss-Prot
  Q63059 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Grb2  growth factor receptor bound protein 2  LOC103690155  uncharacterized LOC103690155  Data Merged 737654 PROVISIONAL
2014-08-25 LOC103690155  uncharacterized LOC103690155      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-20 Grb2  growth factor receptor bound protein 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Grb2  growth factor receptor bound protein 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_homology mammalian homolog of C. elegans Sem-5 728541