GRB2 (growth factor receptor bound protein 2) - Rat Genome Database

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Gene: GRB2 (growth factor receptor bound protein 2) Chlorocebus sabaeus
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Symbol: GRB2
Name: growth factor receptor bound protein 2
RGD ID: 18545909
Description: ENCODES a protein that exhibits enzyme binding (ortholog); epidermal growth factor receptor binding (ortholog); insulin receptor substrate binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); anatomical structure formation involved in morphogenesis (ortholog); branching involved in labyrinthine layer morphogenesis (ortholog); PARTICIPATES IN brain-derived neurotrophic factor signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH breast cancer (ortholog); endometrial carcinoma (ortholog); prostate adenocarcinoma (ortholog); FOUND IN cell cortex (ortholog); presynapse (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: growth factor receptor-bound protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11646,264,818 - 46,346,426 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1646,264,825 - 46,347,156 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607717,032,097 - 17,115,635 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
GRB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11646,264,818 - 46,346,426 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1646,264,825 - 46,347,156 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607717,032,097 - 17,115,635 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
GRB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381775,318,076 - 75,405,678 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1775,318,076 - 75,405,709 (-)EnsemblGRCh38hg38GRCh38
GRCh371773,314,157 - 73,401,759 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361770,825,752 - 70,913,385 (-)NCBINCBI36Build 36hg18NCBI36
Build 341770,825,752 - 70,913,329NCBI
Celera1769,906,645 - 69,994,307 (-)NCBICelera
Cytogenetic Map17q25.1NCBI
HuRef1768,724,752 - 68,824,731 (-)NCBIHuRef
CHM1_11773,378,804 - 73,466,430 (-)NCBICHM1_1
T2T-CHM13v2.01776,210,297 - 76,297,898 (-)NCBIT2T-CHM13v2.0
Grb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911115,534,871 - 115,599,423 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11115,534,871 - 115,599,423 (-)EnsemblGRCm39 Ensembl
GRCm3811115,644,045 - 115,708,597 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11115,644,045 - 115,708,597 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711115,505,444 - 115,569,911 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611115,460,220 - 115,524,687 (-)NCBIMGSCv36mm8
Celera11127,412,389 - 127,476,946 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1180.91NCBI
Grb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810101,380,354 - 101,448,138 (-)NCBIGRCr8
mRatBN7.210100,881,404 - 100,949,193 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10100,869,718 - 100,949,309 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10105,941,694 - 106,010,414 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010105,404,767 - 105,473,487 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010100,802,375 - 100,870,155 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010104,193,953 - 104,263,071 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10104,193,955 - 104,263,071 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010104,019,823 - 104,087,251 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.010104,735,560 - 104,738,091 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410105,722,014 - 105,818,649 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110105,737,088 - 105,833,269 (-)NCBI
Celera1099,455,840 - 99,524,352 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
Grb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555532,186,590 - 2,259,456 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555532,186,590 - 2,258,964 (-)NCBIChiLan1.0ChiLan1.0
GRB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21991,357,798 - 91,445,600 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11796,180,874 - 96,268,408 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01769,265,307 - 69,352,835 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11774,817,471 - 74,904,022 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1774,817,471 - 74,903,796 (-)Ensemblpanpan1.1panPan2
GRB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.195,108,128 - 5,182,091 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl95,117,164 - 5,180,296 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha95,787,497 - 5,861,309 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.095,778,347 - 5,852,258 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl95,778,263 - 5,852,254 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.195,817,381 - 5,891,089 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.095,927,508 - 6,001,301 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.095,988,590 - 6,061,075 (+)NCBIUU_Cfam_GSD_1.0
Grb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056025,750,590 - 5,819,199 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936594592,740 - 661,369 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936594592,760 - 661,369 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl125,940,647 - 6,010,835 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1125,940,723 - 6,009,095 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2125,860,464 - 5,928,885 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Grb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248015,143,141 - 5,219,244 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248015,143,239 - 5,219,136 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GRB2
1472 total Variants

Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000002774   ⟹   ENSCSAP00000001067
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1646,264,825 - 46,347,156 (+)Ensembl
RefSeq Acc Id: XM_008011770   ⟹   XP_008009961
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11646,264,818 - 46,346,426 (+)NCBI
Vero_WHO_p1.0NW_02366607717,032,097 - 17,115,635 (+)NCBI
Sequence:
RefSeq Acc Id: XM_037993841   ⟹   XP_037849769
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607717,036,846 - 17,115,635 (+)NCBI
Protein Sequences
Protein RefSeqs XP_008009961 (Get FASTA)   NCBI Sequence Viewer  
  XP_037849769 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000001067
  ENSCSAP00000001067.1
RefSeq Acc Id: XP_008009961   ⟸   XM_008011770
- UniProtKB: A0A0D9QXH8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000001067   ⟸   ENSCSAT00000002774
RefSeq Acc Id: XP_037849769   ⟸   XM_037993841
- UniProtKB: A0A0D9QXH8 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000004740 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000002774.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro Grb2-like UniProtKB/TrEMBL
  GRB2_C_SH3 UniProtKB/TrEMBL
  GRB2_N_SH3 UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
KEGG Report csab:103243048 UniProtKB/TrEMBL
NCBI Gene GRB2 ENTREZGENE
PANTHER PROTEIN ENHANCER OF SEVENLESS 2B UniProtKB/TrEMBL
Pfam SH2 UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PRINTS P67PHOX UniProtKB/TrEMBL
  SH2DOMAIN UniProtKB/TrEMBL
  SH3DOMAIN UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A0D9QXH8 ENTREZGENE, UniProtKB/TrEMBL