Disc1 (DISC1 scaffold protein) - Rat Genome Database
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Gene: Disc1 (DISC1 scaffold protein) Rattus norvegicus
Analyze
Symbol: Disc1
Name: DISC1 scaffold protein
RGD ID: 631359
Description: Exhibits kinesin binding activity. Involved in several processes, including generation of neurons; protein localization to centrosome; and regulation of glutamatergic synaptic transmission. Localizes to several cellular components, including central region of growth cone; microtubule cytoskeleton; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in autism spectrum disorder (multiple); bipolar disorder; chronic fatigue syndrome; major depressive disorder; and psychotic disorder (multiple). Orthologous to human DISC1 (DISC1 scaffold protein); INTERACTS WITH 17alpha-ethynylestradiol; acetamide; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: disrupted in schizophrenia 1; disrupted in schizophrenia 1 homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01957,818,838 - 58,069,992 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1957,820,260 - 58,066,152 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01968,711,386 - 68,769,050 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01968,529,791 - 68,641,620 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41955,265,116 - 55,449,375 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11955,270,004 - 55,427,798 (+)NCBI
Celera1952,376,528 - 52,580,211 (+)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
1. Fournier NM, etal., Hippocampus. 2009 Jun 4.
2. Fukuda S, etal., Life Sci. 2010 May 8;86(19-20):722-5. Epub 2010 Mar 20.
3. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. GOA data from the GO Consortium
5. Hashimoto R, etal., Hum Mol Genet. 2006 Oct 15;15(20):3024-33. Epub 2006 Sep 7.
6. Hattori T, etal., Mol Psychiatry. 2007 Apr;12(4):398-407. Epub 2007 Jan 23.
7. Hattori T, etal., Mol Psychiatry. 2010 Aug;15(8):778, 798-809. Epub 2010 May 18.
8. Hayashi-Takagi A, etal., Nat Neurosci. 2010 Mar;13(3):327-32. Epub 2010 Feb 7.
9. Hayashi-Takagi A, etal., Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):6461-6. doi: 10.1073/pnas.1321109111. Epub 2014 Apr 3.
10. Hennah W, etal., Mol Psychiatry. 2009 Sep;14(9):865-73. Epub 2008 Mar 4.
11. Hodgkinson CA, etal., Am J Hum Genet. 2004 Nov;75(5):862-72. Epub 2004 Sep 22.
12. Kamiya A, etal., Arch Gen Psychiatry. 2008 Sep;65(9):996-1006. doi: 10.1001/archpsyc.65.9.996.
13. Kamiya A, etal., Hum Mol Genet. 2006 Nov 15;15(22):3313-23. Epub 2006 Oct 11.
14. Kamiya A, etal., Nat Cell Biol. 2005 Dec;7(12):1167-78. Epub 2005 Nov 20.
15. Lepagnol-Bestel AM, etal., Psychiatr Genet. 2010 Dec;20(6):298-303.
16. Marley A and von Zastrow M, PLoS One. 2010 May 28;5(5):e10902.
17. MGD data from the GO Consortium
18. Millar JK, etal., Hum Mol Genet. 2000 May 22;9(9):1415-23.
19. OMIM Disease Annotation Pipeline
20. Ozeki Y, etal., Proc Natl Acad Sci U S A 2003 Jan 7;100(1):289-94.
21. Pletnikov MV, etal., Neurosci Res. 2007 Jul;58(3):234-44. Epub 2007 Mar 16.
22. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. RGD automated import pipeline for gene-chemical interactions
24. Sawamura N, etal., Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):1187-92. Epub 2005 Jan 18.
25. Shinoda T, etal., J Neurosci. 2007 Jan 3;27(1):4-14.
26. Taya S, etal., J Neurosci. 2007 Jan 3;27(1):15-26.
27. Xiao Y, etal., Psychiatr Genet. 2011 Feb;21(1):42-6.
28. Zheng F, etal., Behav Brain Funct. 2011 May 15;7:14.
Additional References at PubMed
PMID:12874605   PMID:15057822   PMID:17825401   PMID:18955030   PMID:18983980   PMID:19303846   PMID:19368862   PMID:19502360   PMID:19778506   PMID:20624590   PMID:20685985   PMID:20838393  
PMID:20880836   PMID:20956536   PMID:21323643   PMID:21471969   PMID:22031837   PMID:22479520   PMID:24301646   PMID:24516667   PMID:24560582   PMID:25224257   PMID:25399920   PMID:25738396  
PMID:26078884   PMID:26385055   PMID:26424793   PMID:30409224   PMID:30723982   PMID:30745562   PMID:31103832  


Genomics

Comparative Map Data
Disc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01957,818,838 - 58,069,992 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1957,820,260 - 58,066,152 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01968,711,386 - 68,769,050 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01968,529,791 - 68,641,620 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41955,265,116 - 55,449,375 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11955,270,004 - 55,427,798 (+)NCBI
Celera1952,376,528 - 52,580,211 (+)NCBICelera
Cytogenetic Map19q12NCBI
DISC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1231,626,815 - 232,041,272 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1231,626,790 - 232,041,272 (+)EnsemblGRCh38hg38GRCh38
GRCh381231,626,790 - 232,041,272 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371231,762,561 - 232,177,018 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361229,829,184 - 230,243,641 (+)NCBINCBI36hg18NCBI36
Build 341228,069,295 - 228,483,607NCBI
Celera1205,027,310 - 205,445,842 (+)NCBI
Cytogenetic Map1q42.2NCBI
HuRef1202,246,109 - 202,664,353 (+)NCBIHuRef
CHM1_11233,036,406 - 233,450,761 (+)NCBICHM1_1
Disc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398125,773,928 - 125,991,882 (+)NCBIGRCm39mm39
GRCm388125,048,767 - 125,265,143 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8125,054,195 - 125,261,858 (+)EnsemblGRCm38mm10GRCm38
MGSCv378127,578,095 - 127,785,051 (+)NCBIGRCm37mm9NCBIm37
MGSCv368127,940,285 - 128,148,274 (+)NCBImm8
Celera8129,364,004 - 129,569,546 (+)NCBICelera
Cytogenetic Map8E2NCBI
cM Map873.26NCBI
Disc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554926,953,389 - 7,239,328 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554926,946,528 - 7,239,328 (-)NCBIChiLan1.0ChiLan1.0
DISC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11212,320,582 - 212,616,406 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1212,265,520 - 212,612,079 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01207,180,513 - 207,594,684 (+)NCBIMhudiblu_PPA_v0panPan3
DISC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl47,524,397 - 7,822,558 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.147,524,336 - 7,825,143 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
LOC101959679
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493648419,151,752 - 19,237,435 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DISC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1458,604,784 - 59,058,289 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11458,606,441 - 58,963,954 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21463,056,095 - 63,124,157 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DISC1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl2568,946,430 - 69,263,198 (+)Ensembl
ChlSab1.12568,886,451 - 69,274,774 (+)NCBI
Disc1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477517,820,590 - 18,165,640 (-)NCBI

Position Markers
D19Rat60  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01958,063,836 - 58,064,029NCBIRnor6.0
Rnor_5.01968,766,731 - 68,766,924UniSTSRnor5.0
RGSC_v3.41955,447,055 - 55,447,249RGDRGSC3.4
RGSC_v3.41955,447,056 - 55,447,249UniSTSRGSC3.4
RGSC_v3.11955,451,937 - 55,452,130RGD
Celera1952,577,892 - 52,578,085UniSTS
Cytogenetic Map19q12UniSTS
RH 3.4 Map19719.2RGD
RH 3.4 Map19719.2UniSTS
SHRSP x BN Map1943.6299UniSTS
SHRSP x BN Map1943.6299RGD
BI296374  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01958,033,016 - 58,033,235NCBIRnor6.0
Rnor_5.01968,736,026 - 68,736,245UniSTSRnor5.0
RGSC_v3.41955,415,475 - 55,415,694UniSTSRGSC3.4
Celera1952,546,340 - 52,546,559UniSTS
Cytogenetic Map19q12UniSTS
RH 3.4 Map19721.2UniSTS
BF415610  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01957,944,392 - 57,944,526NCBIRnor6.0
Rnor_5.01968,652,854 - 68,652,988UniSTSRnor5.0
RGSC_v3.41955,347,455 - 55,347,589UniSTSRGSC3.4
Celera1952,491,163 - 52,491,297UniSTS
Cytogenetic Map19q12UniSTS
RH 3.4 Map19718.4UniSTS
fi45a03.x1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01957,887,854 - 57,889,317NCBIRnor6.0
Rnor_5.01968,597,827 - 68,599,290UniSTSRnor5.0
RGSC_v3.41955,290,605 - 55,292,068UniSTSRGSC3.4
Celera1952,434,546 - 52,436,005UniSTS
Cytogenetic Map19q12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19243296362275575Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19650676160220581Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191899398262275575Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191917749562275575Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)192140778762275575Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192481825762275575Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)193299439262275575Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193791679960220451Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193791679960220451Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)194883071260220581Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)195473521758072143Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:60
Count of miRNA genes:54
Interacting mature miRNAs:59
Transcripts:ENSRNOT00000057945
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 2 43 23 7 19 7 8 8 72 31 37 11 8
Below cutoff 1 34 34 34 3 2 4 4

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_175596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AABR07044093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07044094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07044095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07044096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07044097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07044098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07044099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07044100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07044101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07044102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07044103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07044104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY177674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000057945   ⟹   ENSRNOP00000054753
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1957,820,260 - 58,066,152 (+)Ensembl
RefSeq Acc Id: NM_175596   ⟹   NP_783186
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01957,820,260 - 58,066,155 (+)NCBI
Rnor_5.01968,529,791 - 68,641,620 (+)NCBI
Rnor_5.01968,711,386 - 68,769,050 (+)NCBI
RGSC_v3.41955,265,116 - 55,449,375 (+)RGD
Celera1952,376,528 - 52,580,211 (+)RGD
Sequence:
RefSeq Acc Id: XM_008772616   ⟹   XP_008770838
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01957,818,838 - 58,069,992 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_783186 (Get FASTA)   NCBI Sequence Viewer  
  XP_008770838 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAO19642 (Get FASTA)   NCBI Sequence Viewer  
  EDL96753 (Get FASTA)   NCBI Sequence Viewer  
  Q810H6 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_783186   ⟸   NM_175596
- UniProtKB: Q810H6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008770838   ⟸   XM_008772616
- Peptide Label: isoform X1
- UniProtKB: Q810H6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000054753   ⟸   ENSRNOT00000057945

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
19 68573349 68573350 C T snv HWY/Slc (KyushuU)
19 68610878 68610879 C A snv WKY/N (KNAW), WKY/NHsd (KNAW), WKY/Gcrc (KNAW), WKY/NCrl (KNAW)
19 68613516 68613517 T G snv F344/Jcl (KyushuU)


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
19 57901298 57901299 C A snv WKY/N (MCW), WKY/NHsd (RGD), WKY/Gcrc (RGD)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631359 AgrOrtholog
Ensembl Genes ENSRNOG00000019779 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000054753 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000057945 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro DISC1 UniProtKB/Swiss-Prot
KEGG Report rno:307940 UniProtKB/Swiss-Prot
NCBI Gene 307940 ENTREZGENE
PANTHER PTHR14332 UniProtKB/Swiss-Prot
PhenoGen Disc1 PhenoGen
UniGene Rn.214038 ENTREZGENE
UniProt DISC1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-03-16 Disc1  DISC1 scaffold protein  Disc1  disrupted in schizophrenia 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-11 Disc1  disrupted in schizophrenia 1      Symbol and Name status set to approved 625702 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_mutations_overexpression expression of mutant form reduces neurite extension in PC12 cells 629536
gene_physical_interaction interacts with NudE-like (NUDEL) 629536