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Gene: Disc1 (DISC1 scaffold protein) Rattus norvegicus
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Symbol: Disc1
Name: DISC1 scaffold protein
Description: Exhibits kinesin binding activity. Involved in several processes, including generation of neurons; positive regulation of cell-matrix adhesion; and protein localization to centrosome. Localizes to several cellular components, including the central region of growth cone; cytoplasm; and cytoskeleton. Human ortholog(s) of this gene implicated in autism spectrum disorder (multiple); bipolar disorder; chronic fatigue syndrome; major depressive disorder; and psychotic disorder (multiple). Orthologous to human DISC1 (DISC1 scaffold protein); INTERACTS WITH 17alpha-ethynylestradiol; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: disrupted in schizophrenia 1; disrupted in schizophrenia 1 homolog
Orthologs:
Homo sapiens (human) : DISC1 (DISC1 scaffold protein)  HGNC  Alliance
Mus musculus (house mouse) : Disc1 (disrupted in schizophrenia 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Disc1 (DISC1 scaffold protein)
Canis lupus familiaris (dog) : DISC1 (DISC1 scaffold protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101959679 (disrupted in schizophrenia 1 protein)
Sus scrofa (pig) : DISC1 (DISC1 scaffold protein)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01957,818,838 - 58,069,992 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01968,711,386 - 68,769,050 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01968,529,791 - 68,641,620 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41955,265,116 - 55,449,375 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11955,270,004 - 55,427,798 (+)NCBI
Celera1952,376,528 - 52,580,211 (+)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Disc1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 631359
Created: 2003-08-13
Species: Rattus norvegicus
Last Modified: 2019-06-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.