Enables SH2 domain binding activity; phosphoprotein binding activity; and protein kinase binding activity. Contributes to IgE receptor activity. Involved in several processes, including activation of phospholipase C activity; positive regulation of mast cell degranulation; and protein kinase C-activating G protein-coupled receptor signaling pathway. Located in endosome and membrane raft. Is integral component of plasma membrane. Human ortholog(s) of this gene implicated in asthma; atopic dermatitis; and rhinitis. Orthologous to human MS4A2 (membrane spanning 4-domains A2); PARTICIPATES IN Fc epsilon receptor mediated signaling pathway; asthma pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride.
beta polypeptide); fc epsilon receptor I beta-chain; Fcer1b; fcERI; FCIGA; high affinity immunoglobulin epsilon receptor subunit beta; IgE Fc receptor subunit beta; Membrane-spanning 4-domains subfamily A member 1; membrane-spanning 4-domains subfamily A member 2; Membrane-spanning 4-domains, subfamily A, member 1; membrane-spanning 4-domains, subfamily A, member 2; membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for, beta polypeptide); Ms4a1
MS4A2 protein mutant form inhibits the reaction [Antigens results in increased abundance of Hydrogen Peroxide], MS4A2 protein mutant form inhibits the reaction [wortmannin inhibits the reaction [Antigens results in increased abundance of Hydrogen Peroxide]]
1-Butanol inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased phosphorylation of and affects the localization of MS4A2 protein], 1-Butanol results in increased phosphorylation of and affects the localization of MS4A2 protein
[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of MS4A2 mRNA, fulvic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of MS4A2 mRNA]
MS4A2 protein mutant form inhibits the reaction [Antigens results in increased abundance of Hydrogen Peroxide], MS4A2 protein mutant form inhibits the reaction [wortmannin inhibits the reaction [Antigens results in increased abundance of Hydrogen Peroxide]]
methyl-beta-cyclodextrin inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased phosphorylation of and affects the localization of MS4A2 protein]
GSTM1 gene SNP affects the reaction [MS4A2 gene SNP affects the susceptibility to Ozone], GSTP1 gene SNP affects the reaction [MS4A2 gene SNP affects the susceptibility to Ozone]
[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of MS4A2 mRNA, fulvic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of MS4A2 mRNA]
A new variant of the beta subunit of the high-affinity receptor for immunoglobulin E (Fc epsilon RI-beta E237G): associations with measures of atopy and bronchial hyper-responsiveness.
Association and functional relevance of E237G, a polymorphism of the high-affinity immunoglobulin E-receptor beta chain gene, to airway hyper-responsiveness.
Downstream signaling molecules bind to different phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) peptides of the high affinity IgE receptor.
Regulation of rat basophilic leukemia-2H3 mast cell secretion by a constitutive Lyn kinase interaction with the high affinity IgE receptor (Fc epsilon RI).
Detergent-resistant membrane domains are required for mast cell activation but dispensable for tyrosine phosphorylation upon aggregation of the high affinity receptor for IgE.
