Exhibits SH2 domain binding activity; phosphoprotein binding activity; and protein kinase binding activity. Contributes to IgE receptor activity. Involved in several processes, including activation of phospholipase C activity; positive regulation of mast cell degranulation; and protein kinase C-activating G protein-coupled receptor signaling pathway. Localizes to the endosome; integral component of plasma membrane; and membrane raft. Human ortholog(s) of this gene implicated in asthma; atopic dermatitis; and rhinitis. Orthologous to human MS4A2 (membrane spanning 4-domains A2); PARTICIPATES IN Fc epsilon receptor mediated signaling pathway; asthma pathway; INTERACTS WITH 1-naphthyl isothiocyanate; ammonium chloride; bisphenol A.
beta polypeptide); fc epsilon receptor I beta-chain; Fcer1b; fcERI; FCIGA; high affinity immunoglobulin epsilon receptor subunit beta; IgE Fc receptor subunit beta; Membrane-spanning 4-domains subfamily A member 1; membrane-spanning 4-domains subfamily A member 2; Membrane-spanning 4-domains, subfamily A, member 1; membrane-spanning 4-domains, subfamily A, member 2; membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for, beta polypeptide); Ms4a1
MS4A2 protein mutant form inhibits the reaction [Antigens results in increased abundance of Hydrogen Peroxide], MS4A2 protein mutant form inhibits the reaction [wortmannin inhibits the reaction [Antigens results in increased abundance of Hydrogen Peroxide]]
1-Butanol inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased phosphorylation of and affects the localization of MS4A2 protein], 1-Butanol results in increased phosphorylation of and affects the localization of MS4A2 protein
[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of MS4A2 mRNA, fulvic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of MS4A2 mRNA]
MS4A2 protein mutant form inhibits the reaction [Antigens results in increased abundance of Hydrogen Peroxide], MS4A2 protein mutant form inhibits the reaction [wortmannin inhibits the reaction [Antigens results in increased abundance of Hydrogen Peroxide]]
methyl-beta-cyclodextrin inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased phosphorylation of and affects the localization of MS4A2 protein]
GSTM1 gene SNP affects the reaction [MS4A2 gene SNP affects the susceptibility to Ozone], GSTP1 gene SNP affects the reaction [MS4A2 gene SNP affects the susceptibility to Ozone]
[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of MS4A2 mRNA, fulvic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of MS4A2 mRNA]
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Gene-Chemical Interaction Annotations
