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Gene: Irs1 (insulin receptor substrate 1) Rattus norvegicus
Symbol: Irs1
Name: insulin receptor substrate 1
Description: Exhibits several functions, including SH2 domain binding activity; protein kinase binding activity; and signaling receptor binding activity. Involved in several processes, including cellular response to peptide hormone stimulus; regulation of insulin receptor signaling pathway; and regulation of peptide hormone secretion. Localizes to cytosol; insulin receptor complex; and intracellular membrane-bounded organelle. Used to study end stage renal disease; obesity; and type 2 diabetes mellitus. Biomarker of Alzheimer's disease; non-alcoholic fatty liver disease; and osteoporosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; and type 2 diabetes mellitus. Orthologous to human IRS1 (insulin receptor substrate 1); PARTICIPATES IN insulin signaling pathway; insulin-like growth factor signaling pathway; interleukin-2 signaling pathway; INTERACTS WITH (S)-nicotine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
Also known as: IRS-1; IRS1IRM; pp185
Homo sapiens (human) : IRS1 (insulin receptor substrate 1)  HGNC  Alliance
Mus musculus (house mouse) : Irs1 (insulin receptor substrate 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Irs1 (insulin receptor substrate 1)
Pan paniscus (bonobo/pygmy chimpanzee) : IRS1 (insulin receptor substrate 1)
Canis lupus familiaris (dog) : IRS1 (insulin receptor substrate 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Irs1 (insulin receptor substrate 1)
Sus scrofa (pig) : IRS1 (insulin receptor substrate 1)
Chlorocebus sabaeus (African green monkey) : IRS1 (insulin receptor substrate 1)
Heterocephalus glaber (naked mole-rat) : Irs1 (insulin receptor substrate 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0988,033,668 - 88,086,488 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl988,033,668 - 88,086,488 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0987,782,499 - 87,835,248 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4981,585,251 - 81,638,071 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1981,768,669 - 81,821,490 (-)NCBI
Celera980,997,490 - 81,050,250 (-)NCBICelera
Cytogenetic Map9q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Irs1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2922
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.