(+)-catechin multiple interactions ISO RGD:733473 6480464 Catechin inhibits the reaction [Glucose results in decreased expression of IRS1 protein modified form], Catechin inhibits the reaction [Glucose results in decreased expression of IRS1 protein] CTD PMID:24262486 (1->4)-beta-D-glucan multiple interactions ISO RGD:10816 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of IRS1 mRNA CTD PMID:36331819 (S)-nicotine decreases expression EXP 6480464 Nicotine results in decreased expression of IRS1 mRNA CTD PMID:22265867 (Z)-ligustilide decreases phosphorylation ISO RGD:733473 6480464 ligustilide results in decreased phosphorylation of IRS1 protein CTD PMID:23973442 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of IRS1 mRNA CTD PMID:29097150 17beta-estradiol decreases expression EXP 6480464 Estradiol results in decreased expression of IRS1 protein CTD PMID:22142692 17beta-estradiol multiple interactions EXP 6480464 [bisphenol A co-treated with Estradiol] results in increased expression of IRS1 mRNA CTD PMID:26496021 17beta-estradiol increases phosphorylation ISO RGD:733473 6480464 Estradiol results in increased phosphorylation of IRS1 protein CTD PMID:23933164 17beta-estradiol increases expression ISO RGD:733473 6480464 Estradiol results in increased expression of IRS1 mRNA, Estradiol results in increased expression of IRS1 protein modified form CTD PMID:15072547 more ... 17beta-estradiol increases phosphorylation ISO RGD:10816 6480464 Estradiol results in increased phosphorylation of IRS1 protein CTD PMID:15604210 17beta-estradiol decreases phosphorylation ISO RGD:733473 6480464 Estradiol results in decreased phosphorylation of IRS1 protein CTD PMID:15949379 17beta-estradiol multiple interactions ISO RGD:733473 6480464 1 more ... CTD PMID:15072547 more ... 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:10816 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:733473 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of IRS1 mRNA, Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of IRS1 mRNA] CTD PMID:15688983 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 Tetrachlorodibenzodioxin inhibits the reaction [IGF1 protein results in increased phosphorylation of IRS1 protein] CTD PMID:23639626 2,3,7,8-tetrachlorodibenzodioxine decreases phosphorylation EXP 6480464 Tetrachlorodibenzodioxin results in decreased phosphorylation of IRS1 protein CTD PMID:23639626 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of IRS1 mRNA CTD PMID:20959002 more ... 2,3,7,8-tetrachlorodibenzodioxine increases phosphorylation ISO RGD:733473 6480464 Tetrachlorodibenzodioxin results in increased phosphorylation of IRS1 protein CTD PMID:9683191 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:733473 6480464 Tetrachlorodibenzodioxin results in increased expression of IRS1 mRNA CTD PMID:21632981 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:10816 6480464 Tetrachlorodibenzodioxin results in decreased expression of IRS1 mRNA, Tetrachlorodibenzodioxin results in decreased expression of IRS1 protein CTD PMID:18691609 more ... 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:10816 6480464 Tetrachlorodibenzodioxin results in increased expression of IRS1 mRNA CTD PMID:17407152 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:10816 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:17407152 more ... 2,3,7,8-Tetrachlorodibenzofuran decreases expression EXP 6480464 2 more ... CTD PMID:32109520 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of IRS1 mRNA CTD PMID:21346803 3,3',4,4',5-pentachlorobiphenyl decreases expression EXP 6480464 3 more ... CTD PMID:20959002 3,3',4,4',5-pentachlorobiphenyl decreases expression ISO RGD:733473 6480464 3 more ... CTD PMID:35618242 3,3',5,5'-tetrabromobisphenol A increases expression ISO RGD:10816 6480464 tetrabromobisphenol A results in increased expression of IRS1 mRNA CTD PMID:30496566 3,4-methylenedioxymethamphetamine decreases expression ISO RGD:10816 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of IRS1 mRNA CTD PMID:26251327 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:10816 6480464 3 more ... CTD PMID:22298784 3-methyladenine multiple interactions ISO RGD:733473 6480464 3-methyladenine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of IRS1 protein] CTD PMID:30362509 3-methylcholanthrene decreases expression ISO RGD:10816 6480464 Methylcholanthrene results in decreased expression of IRS1 mRNA CTD PMID:29554273 4,4'-sulfonyldiphenol increases expression ISO RGD:10816 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of IRS1 mRNA CTD PMID:33297965 4,4'-sulfonyldiphenol increases methylation ISO RGD:733473 6480464 bis(4-hydroxyphenyl)sulfone results in increased methylation of IRS1 gene CTD PMID:31601247 4-nitrophenol decreases expression ISO RGD:10816 6480464 4-nitrophenol results in decreased expression of IRS1 mRNA CTD PMID:34673133 4-phenylbutyric acid multiple interactions ISO RGD:10816 6480464 4-phenylbutyric acid inhibits the reaction [titanium dioxide results in increased phosphorylation of IRS1 protein] CTD PMID:31298478 8-Br-cAMP increases expression ISO RGD:733473 6480464 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of IRS1 mRNA CTD PMID:22079614 9-cis,11-trans-octadecadienoic acid multiple interactions ISO RGD:10816 6480464 cis-9, trans-11-conjugated linoleic acid inhibits the reaction [TNF protein results in decreased expression of IRS1 mRNA] CTD PMID:17327424 9-cis,11-trans-octadecadienoic acid multiple interactions EXP 6480464 [trans-10 more ... CTD PMID:17408517 acetylsalicylic acid affects response to substance ISO RGD:733473 6480464 IRS1 polymorphism affects the susceptibility to Aspirin CTD PMID:15066917 acrylamide decreases expression EXP 6480464 Acrylamide results in decreased expression of IRS1 mRNA CTD PMID:28959563 , PMID:31644924 afimoxifene increases expression ISO RGD:733473 6480464 afimoxifene results in increased expression of IRS1 mRNA CTD PMID:15072547 aflatoxin B1 decreases methylation ISO RGD:733473 6480464 Aflatoxin B1 results in decreased methylation of IRS1 gene CTD PMID:27153756 aflatoxin B1 decreases expression ISO RGD:733473 6480464 Aflatoxin B1 results in decreased expression of IRS1 mRNA CTD PMID:22100608 more ... aldehydo-D-glucose multiple interactions ISO RGD:733473 6480464 ACACB protein affects the reaction [Glucose results in decreased phosphorylation of IRS1 protein] more ... CTD PMID:10430617 more ... aldehydo-D-glucose decreases phosphorylation ISO RGD:733473 6480464 Glucose results in decreased phosphorylation of IRS1 protein CTD PMID:33957017 aldehydo-D-glucose decreases expression ISO RGD:733473 6480464 Glucose results in decreased expression of IRS1 protein, Glucose results in decreased expression of IRS1 protein modified form CTD PMID:24262486 aldehydo-D-glucose increases phosphorylation ISO RGD:733473 6480464 Glucose results in increased phosphorylation of IRS1 protein CTD PMID:10430617 all-trans-retinoic acid decreases expression ISO RGD:733473 6480464 Tretinoin results in decreased expression of IRS1 mRNA CTD PMID:23724009 allopurinol multiple interactions EXP 6480464 Allopurinol inhibits the reaction [Fructose results in decreased phosphorylation of IRS1 protein] CTD PMID:22426011 alloxan affects phosphorylation ISO RGD:10816 6480464 Alloxan affects the phosphorylation of IRS1 protein CTD PMID:26827782 alloxan multiple interactions ISO RGD:10816 6480464 Phycocyanin inhibits the reaction [Alloxan affects the phosphorylation of IRS1 protein] CTD PMID:26827782 alloxan decreases phosphorylation EXP 6480464 Alloxan results in decreased phosphorylation of IRS1 protein CTD PMID:22138235 alloxan multiple interactions EXP 6480464 Taurine inhibits the reaction [Alloxan results in decreased phosphorylation of IRS1 protein] CTD PMID:22138235 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of IRS1 mRNA CTD PMID:16483693 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions EXP 6480464 pyrazolanthrone inhibits the reaction [Paroxetine affects the reaction [INS protein affects the phosphorylation of IRS1 protein]] CTD PMID:17728140 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO RGD:733473 6480464 pyrazolanthrone inhibits the reaction [bisphenol A results in increased expression of IRS1 protein modified form] CTD PMID:29793316 antirheumatic drug increases expression ISO RGD:733473 6480464 Antirheumatic Agents results in increased expression of IRS1 mRNA CTD PMID:24449571 arsane multiple interactions ISO RGD:733473 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of IRS1 mRNA CTD PMID:32525701 arsenic atom multiple interactions ISO RGD:733473 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of IRS1 mRNA CTD PMID:32525701 arsenite(3-) decreases methylation ISO RGD:733473 6480464 arsenite results in decreased methylation of IRS1 promoter CTD PMID:23974009 arsenite(3-) multiple interactions ISO RGD:10816 6480464 [sodium arsenite results in increased abundance of arsenite] which results in decreased expression of IRS1 protein CTD PMID:35090851 arsenite(3-) multiple interactions ISO RGD:733473 6480464 Fulvestrant inhibits the reaction [arsenite results in increased expression of IRS1 mRNA] CTD PMID:31646340 arsenite(3-) increases expression ISO RGD:733473 6480464 arsenite results in increased expression of IRS1 mRNA CTD PMID:31646340 arsenite(3-) decreases expression ISO RGD:733473 6480464 arsenite results in decreased expression of IRS1 mRNA CTD PMID:31935557 arsenous acid increases phosphorylation ISO RGD:733473 6480464 Arsenic Trioxide results in increased phosphorylation of IRS1 protein CTD PMID:30362509 arsenous acid decreases expression ISO RGD:733473 6480464 Arsenic Trioxide results in decreased expression of IRS1 mRNA CTD PMID:20458559 arsenous acid affects response to substance ISO RGD:733473 6480464 IRS1 mRNA affects the susceptibility to Arsenic Trioxide CTD PMID:23911876 arsenous acid multiple interactions ISO RGD:733473 6480464 3-methyladenine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of IRS1 protein] more ... CTD PMID:30362509 atrazine affects phosphorylation ISO RGD:733473 6480464 Atrazine affects the phosphorylation of IRS1 protein CTD PMID:22378314 azathioprine multiple interactions ISO RGD:733473 6480464 Azathioprine results in increased phosphorylation of and results in decreased expression of IRS1 protein CTD PMID:23958494 benzo[a]pyrene increases expression ISO RGD:10816 6480464 Benzo(a)pyrene results in increased expression of IRS1 mRNA CTD PMID:19770486 benzo[a]pyrene increases methylation ISO RGD:733473 6480464 Benzo(a)pyrene results in increased methylation of IRS1 promoter CTD PMID:27901495 benzo[a]pyrene affects methylation ISO RGD:733473 6480464 Benzo(a)pyrene affects the methylation of IRS1 3' UTR, Benzo(a)pyrene affects the methylation of IRS1 exon CTD PMID:27901495 benzo[a]pyrene decreases expression ISO RGD:733473 6480464 Benzo(a)pyrene results in decreased expression of IRS1 mRNA CTD PMID:26238291 benzo[a]pyrene increases phosphorylation ISO RGD:733473 6480464 Benzo(a)pyrene results in increased phosphorylation of IRS1 protein CTD PMID:9683191 benzo[a]pyrene increases expression ISO RGD:733473 6480464 Benzo(a)pyrene results in increased expression of IRS1 mRNA CTD PMID:21632981 benzo[a]pyrene decreases expression ISO RGD:10816 6480464 Benzo(a)pyrene results in decreased expression of IRS1 mRNA CTD PMID:21569818 benzo[a]pyrene diol epoxide I affects expression ISO RGD:733473 6480464 7 more ... CTD PMID:20382639 biotin multiple interactions EXP 6480464 [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride affects the phosphorylation of IRS1 protein], Biotin inhibits the reaction [Aluminum Chloride affects the phosphorylation of IRS1 protein] CTD PMID:32383521 bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 [Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of IRS1 protein] more ... CTD PMID:21911000 , PMID:28526321 bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:10816 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 , PMID:33484791 bis(2-ethylhexyl) phthalate increases phosphorylation ISO RGD:10816 6480464 Diethylhexyl Phthalate results in increased phosphorylation of IRS1 protein CTD PMID:33484791 bis(2-ethylhexyl) phthalate affects phosphorylation EXP 6480464 Diethylhexyl Phthalate affects the phosphorylation of IRS1 protein CTD PMID:25280772 bis(2-ethylhexyl) phthalate decreases phosphorylation EXP 6480464 Diethylhexyl Phthalate results in decreased phosphorylation of IRS1 protein CTD PMID:21911000 bis(2-ethylhexyl) phthalate increases expression EXP 6480464 Diethylhexyl Phthalate results in increased expression of IRS1 mRNA CTD PMID:21911000 bis(2-ethylhexyl) phthalate decreases expression EXP 6480464 Diethylhexyl Phthalate results in decreased expression of IRS1 protein CTD PMID:21911000 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of IRS1 mRNA, bisphenol A results in decreased expression of IRS1 protein CTD PMID:22142692 more ... bisphenol A increases phosphorylation EXP 6480464 bisphenol A results in increased phosphorylation of IRS1 protein CTD PMID:34973380 bisphenol A decreases phosphorylation EXP 6480464 bisphenol A results in decreased phosphorylation of IRS1 protein CTD PMID:28153594 , PMID:33315269 bisphenol A multiple interactions ISO RGD:10816 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of IRS1 mRNA, bisphenol A results in increased expression of IRS1 protein CTD PMID:27836638 , PMID:33296240 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of IRS1 mRNA CTD PMID:25181051 bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with Estradiol] results in increased expression of IRS1 mRNA more ... CTD PMID:26496021 more ... bisphenol A increases phosphorylation ISO RGD:10816 6480464 bisphenol A results in increased phosphorylation of IRS1 protein CTD PMID:26779933 , PMID:26923231 bisphenol A decreases phosphorylation ISO RGD:10816 6480464 bisphenol A results in decreased phosphorylation of IRS1 protein CTD PMID:25637671 more ... bisphenol A decreases expression ISO RGD:10816 6480464 bisphenol A results in decreased expression of IRS1 mRNA CTD PMID:26779933 , PMID:35489422 bisphenol A increases phosphorylation ISO RGD:733473 6480464 bisphenol A results in increased phosphorylation of IRS1 protein CTD PMID:23933164 bisphenol A multiple interactions ISO RGD:733473 6480464 Curcumin inhibits the reaction [bisphenol A results in increased expression of IRS1 protein modified form] more ... CTD PMID:23810794 more ... bisphenol A increases expression ISO RGD:10816 6480464 bisphenol A results in increased expression of IRS1 protein CTD PMID:22470480 bisphenol A increases expression ISO RGD:733473 6480464 bisphenol A results in increased expression of IRS1 mRNA, bisphenol A results in increased expression of IRS1 protein modified form CTD PMID:16029874 more ... bisphenol F increases expression ISO RGD:10816 6480464 bisphenol F results in increased expression of IRS1 mRNA CTD PMID:30951980 bortezomib decreases degradation ISO RGD:733473 6480464 Bortezomib results in decreased degradation of IRS1 protein CTD PMID:16227402 buta-1,3-diene decreases expression ISO RGD:10816 6480464 1, 3-butadiene results in decreased expression of IRS1 mRNA CTD PMID:29038090 Butylbenzyl phthalate decreases expression ISO RGD:10816 6480464 butylbenzyl phthalate results in decreased expression of IRS1 mRNA CTD PMID:33395283 cadmium atom multiple interactions EXP 6480464 [Streptozocin co-treated with Cadmium] results in decreased expression of IRS1 protein, myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in decreased expression of IRS1 protein] CTD PMID:24923654 cadmium atom increases expression ISO RGD:733473 6480464 Cadmium results in increased expression of IRS1 mRNA CTD PMID:31646340 cadmium atom multiple interactions ISO RGD:10816 6480464 [Cadmium co-treated with Mercury] results in increased phosphorylation of IRS1 protein CTD PMID:30629257 cadmium dichloride multiple interactions ISO RGD:10816 6480464 [Cadmium Chloride co-treated with methylmercuric chloride] results in decreased expression of IRS1 mRNA, [Cadmium Chloride co-treated with methylmercuric chloride] results in increased phosphorylation of IRS1 protein CTD PMID:27814245 , PMID:30629257 cadmium dichloride decreases expression ISO RGD:733473 6480464 Cadmium Chloride results in decreased expression of IRS1 mRNA CTD PMID:33129824 caffeine affects phosphorylation ISO RGD:733473 6480464 Caffeine affects the phosphorylation of IRS1 protein CTD PMID:35688186 calcitriol increases expression ISO RGD:733473 6480464 Calcitriol results in increased expression of IRS1 mRNA CTD PMID:16002434 , PMID:26485663 cannabidiol multiple interactions ISO RGD:733473 6480464 [Cannabidiol co-treated with moringin] results in decreased expression of IRS1 mRNA CTD PMID:30096889 capsaicin increases expression ISO RGD:10816 6480464 Capsaicin results in increased expression of IRS1 mRNA CTD PMID:19798065 carbamazepine affects expression ISO RGD:733473 6480464 Carbamazepine affects the expression of IRS1 mRNA CTD PMID:24752500 carbon nanotube decreases expression ISO RGD:10816 6480464 Nanotubes more ... CTD PMID:25554681 , PMID:25620056 carmustine decreases expression ISO RGD:733473 6480464 Carmustine results in decreased expression of IRS1 mRNA CTD PMID:15980968 chloroprene decreases expression ISO RGD:10816 6480464 Chloroprene results in decreased expression of IRS1 mRNA CTD PMID:23125180 chlorpyrifos multiple interactions EXP 6480464 Chlorpyrifos inhibits the reaction [INS1 protein results in increased phosphorylation of IRS1 protein] CTD PMID:30918868 cholesterol affects abundance ISO RGD:733473 6480464 IRS1 gene polymorphism affects the abundance of Cholesterol CTD PMID:10591678 choline multiple interactions ISO RGD:10816 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of IRS1 gene CTD PMID:20938992 chromium atom increases phosphorylation ISO RGD:10816 6480464 Chromium results in increased phosphorylation of IRS1 protein CTD PMID:15516700 chromium atom multiple interactions EXP 6480464 Chromium promotes the reaction [INS1 protein results in increased phosphorylation of IRS1 protein] CTD PMID:16424121 chromium atom multiple interactions ISO RGD:10816 6480464 Chromium inhibits the reaction [Dietary Fats results in decreased expression of IRS1 protein] CTD PMID:20513351 chromium atom affects expression EXP 6480464 Chromium affects the expression of IRS1 mRNA CTD PMID:15862035 chromium(6+) multiple interactions ISO RGD:733473 6480464 MIR143 inhibits the reaction [chromium hexavalent ion results in increased expression of IRS1 protein] CTD PMID:23748240 chromium(6+) multiple interactions EXP 6480464 chromium hexavalent ion results in decreased expression of and results in decreased phosphorylation of IRS1 protein CTD PMID:28911802 chromium(6+) increases expression ISO RGD:733473 6480464 chromium hexavalent ion results in increased expression of IRS1 protein CTD PMID:23748240 cisplatin increases expression ISO RGD:10816 6480464 Cisplatin results in increased expression of IRS1 mRNA CTD PMID:21151649 cisplatin decreases response to substance ISO RGD:733473 6480464 IRS1 results in decreased susceptibility to Cisplatin CTD PMID:21849418 cisplatin decreases expression ISO RGD:733473 6480464 Cisplatin results in decreased expression of IRS1 mRNA CTD PMID:19561079 , PMID:27392435 cobalt dichloride decreases expression ISO RGD:733473 6480464 cobaltous chloride results in decreased expression of IRS1 mRNA CTD PMID:19376846 coenzyme Q10 multiple interactions EXP 6480464 [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride affects the phosphorylation of IRS1 protein], coenzyme Q10 inhibits the reaction [Aluminum Chloride affects the phosphorylation of IRS1 protein] CTD PMID:32383521 colforsin daropate hydrochloride multiple interactions ISO RGD:10816 6480464 Colforsin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IRS1 mRNA] CTD PMID:17407152 copper atom multiple interactions ISO RGD:733473 6480464 [Chelating Agents binds to Copper] which results in decreased expression of IRS1 mRNA CTD PMID:30911355 copper(0) multiple interactions ISO RGD:733473 6480464 [Chelating Agents binds to Copper] which results in decreased expression of IRS1 mRNA CTD PMID:30911355 copper(II) sulfate increases expression ISO RGD:733473 6480464 Copper Sulfate results in increased expression of IRS1 mRNA CTD PMID:19549813 coumarin affects phosphorylation ISO RGD:733473 6480464 coumarin affects the phosphorylation of IRS1 protein CTD PMID:35688186 coumestrol multiple interactions ISO RGD:733473 6480464 [Coumestrol co-treated with ESR1 protein] results in increased expression of IRS1 mRNA, ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of IRS1 mRNA] CTD PMID:18310284 CU-O LINKAGE decreases expression ISO RGD:733473 6480464 cupric oxide results in decreased expression of IRS1 mRNA CTD PMID:22077320 curcumin multiple interactions EXP 6480464 Curcumin inhibits the reaction [Fructose affects the phosphorylation of IRS1 protein] CTD PMID:26713546 curcumin multiple interactions ISO RGD:733473 6480464 Curcumin inhibits the reaction [bisphenol A results in increased expression of IRS1 protein modified form] CTD PMID:29793316 curcumin affects phosphorylation ISO RGD:10816 6480464 Curcumin affects the phosphorylation of IRS1 protein CTD PMID:27208389 cycloheximide decreases expression ISO RGD:733473 6480464 Cycloheximide results in decreased expression of IRS1 mRNA CTD PMID:15072547 cycloheximide multiple interactions ISO RGD:733473 6480464 [Cycloheximide co-treated with Estradiol] results in increased expression of IRS1 mRNA CTD PMID:15072547 cyclophosphamide multiple interactions ISO RGD:733473 6480464 [Doxorubicin co-treated with Cyclophosphamide] affects the expression of IRS1 mRNA CTD PMID:16322899 cyclosporin A decreases expression ISO RGD:733473 6480464 Cyclosporine results in decreased expression of IRS1 mRNA CTD PMID:20106945 cyclosporin A decreases expression ISO RGD:10816 6480464 Cyclosporine results in decreased expression of IRS1 mRNA CTD PMID:19770486 cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of IRS1 mRNA CTD PMID:21865292 D-glucose multiple interactions ISO RGD:733473 6480464 ACACB protein affects the reaction [Glucose results in decreased phosphorylation of IRS1 protein] more ... CTD PMID:10430617 more ... D-glucose decreases phosphorylation ISO RGD:733473 6480464 Glucose results in decreased phosphorylation of IRS1 protein CTD PMID:33957017 D-glucose decreases expression ISO RGD:733473 6480464 Glucose results in decreased expression of IRS1 protein, Glucose results in decreased expression of IRS1 protein modified form CTD PMID:24262486 D-glucose increases phosphorylation ISO RGD:733473 6480464 Glucose results in increased phosphorylation of IRS1 protein CTD PMID:10430617 decabromodiphenyl ether increases expression ISO RGD:10816 6480464 decabromobiphenyl ether results in increased expression of IRS1 protein modified form CTD PMID:30743236 dehydroepiandrosterone decreases phosphorylation EXP 6480464 Dehydroepiandrosterone results in decreased phosphorylation of IRS1 protein CTD PMID:27634381 dehydroepiandrosterone multiple interactions EXP 6480464 Metformin inhibits the reaction [Dehydroepiandrosterone results in decreased phosphorylation of IRS1 protein], Quercetin inhibits the reaction [Dehydroepiandrosterone results in decreased phosphorylation of IRS1 protein] CTD PMID:27634381 dexamethasone multiple interactions ISO RGD:10816 6480464 3 more ... CTD PMID:18812026 more ... dexamethasone decreases expression ISO RGD:733473 6480464 Dexamethasone results in decreased expression of IRS1 mRNA CTD PMID:32976960 dexamethasone affects expression ISO RGD:733473 6480464 Dexamethasone affects the expression of IRS1 mRNA, Dexamethasone affects the expression of IRS1 protein CTD PMID:31181236 dexamethasone multiple interactions EXP 6480464 Testosterone inhibits the reaction [Dexamethasone results in decreased expression of IRS1 mRNA] CTD PMID:20032058 dexamethasone decreases expression EXP 6480464 Dexamethasone results in decreased expression of IRS1 mRNA, Dexamethasone results in decreased expression of IRS1 protein CTD PMID:20032058 , PMID:35148621 dexamethasone decreases expression ISO RGD:10816 6480464 Dexamethasone results in decreased expression of IRS1 mRNA CTD PMID:18812026 dextran sulfate multiple interactions ISO RGD:10816 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of IRS1 mRNA CTD PMID:29950665 diarsenic trioxide multiple interactions ISO RGD:733473 6480464 3-methyladenine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of IRS1 protein] more ... CTD PMID:30362509 diarsenic trioxide increases phosphorylation ISO RGD:733473 6480464 Arsenic Trioxide results in increased phosphorylation of IRS1 protein CTD PMID:30362509 diarsenic trioxide decreases expression ISO RGD:733473 6480464 Arsenic Trioxide results in decreased expression of IRS1 mRNA CTD PMID:20458559 diarsenic trioxide affects response to substance ISO RGD:733473 6480464 IRS1 mRNA affects the susceptibility to Arsenic Trioxide CTD PMID:23911876 dibenz[a,h]anthracene decreases expression ISO RGD:10816 6480464 1 more ... CTD PMID:26377693 diclofenac affects expression ISO RGD:733473 6480464 Diclofenac affects the expression of IRS1 mRNA CTD PMID:24752500 diclofenac affects expression ISO RGD:10816 6480464 Diclofenac affects the expression of IRS1 mRNA CTD PMID:26934552 dicrotophos increases expression ISO RGD:733473 6480464 dicrotophos results in increased expression of IRS1 mRNA CTD PMID:28302478 Didymin multiple interactions ISO RGD:733473 6480464 didymin inhibits the reaction [INS protein results in decreased phosphorylation of IRS1 protein] CTD PMID:30928401 dioxygen multiple interactions ISO RGD:10816 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of IRS1 mRNA CTD PMID:30529165 disodium selenite multiple interactions ISO RGD:10816 6480464 Sodium Selenite promotes the reaction [[Streptozocin co-treated with Dietary Fats] affects the phosphorylation of IRS1 protein] CTD PMID:26522834 dorsomorphin multiple interactions ISO RGD:733473 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin multiple interactions ISO RGD:733473 6480464 [Doxorubicin co-treated with Cyclophosphamide] affects the expression of IRS1 mRNA CTD PMID:16322899 doxorubicin decreases expression ISO RGD:733473 6480464 Doxorubicin results in decreased expression of IRS1 mRNA CTD PMID:29803840 ethanol decreases phosphorylation EXP 6480464 Ethanol results in decreased phosphorylation of IRS1 protein CTD PMID:12700235 ethanol decreases phosphorylation ISO RGD:10816 6480464 Ethanol results in decreased phosphorylation of IRS1 protein CTD PMID:28131861 ethanol multiple interactions EXP 6480464 [Ethanol results in decreased susceptibility to INS1 protein] which results in decreased expression of and results in decreased activity of IRS1 protein CTD PMID:12700235 ethanol affects phosphorylation ISO RGD:10816 6480464 Ethanol affects the phosphorylation of IRS1 protein CTD PMID:18377926 flavonol multiple interactions ISO RGD:733473 6480464 3-hydroxyflavone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of IRS1 protein] CTD PMID:17458902 folic acid multiple interactions ISO RGD:10816 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of IRS1 gene CTD PMID:20938992 folic acid decreases expression ISO RGD:10816 6480464 Folic Acid results in decreased expression of IRS1 mRNA CTD PMID:25629700 folpet increases expression ISO RGD:10816 6480464 folpet results in increased expression of IRS1 mRNA CTD PMID:31558096 formaldehyde decreases expression ISO RGD:733473 6480464 Formaldehyde results in decreased expression of IRS1 mRNA CTD PMID:20655997 , PMID:27664576 fructose decreases phosphorylation EXP 6480464 Fructose results in decreased phosphorylation of IRS1 protein CTD PMID:22426011 fructose increases phosphorylation ISO RGD:10816 6480464 Fructose results in increased phosphorylation of IRS1 protein CTD PMID:31672515 fructose affects phosphorylation EXP 6480464 Fructose affects the phosphorylation of IRS1 protein CTD PMID:26713546 fructose increases phosphorylation EXP 6480464 Fructose results in increased phosphorylation of IRS1 protein CTD PMID:24704288 fructose decreases expression EXP 6480464 Fructose results in decreased expression of IRS1 mRNA, Fructose results in decreased expression of IRS1 protein CTD PMID:19008412 , PMID:19165636 fructose multiple interactions EXP 6480464 [Fructose co-treated with Oleanolic Acid] results in increased expression of IRS1 mRNA more ... CTD PMID:19008412 more ... fulvestrant decreases expression ISO RGD:733473 6480464 fulvestrant results in decreased expression of IRS1 mRNA CTD PMID:15072547 fulvestrant multiple interactions ISO RGD:733473 6480464 Fulvestrant inhibits the reaction [[Hexachlorobenzene co-treated with Estradiol] results in increased phosphorylation of IRS1 protein] more ... CTD PMID:19879930 , PMID:31646340 gamma-hexachlorocyclohexane decreases phosphorylation EXP 6480464 Hexachlorocyclohexane results in decreased phosphorylation of IRS1 protein CTD PMID:30248393 Ganoderic acid A multiple interactions ISO RGD:10816 6480464 [Dietary Fats co-treated with ganoderic acid A] affects the expression of IRS1 mRNA CTD PMID:29852127 genistein multiple interactions ISO RGD:733473 6480464 Genistein inhibits the reaction [bisphenol A results in increased phosphorylation of IRS1 protein], Genistein inhibits the reaction [Estradiol results in increased phosphorylation of IRS1 protein] CTD PMID:23933164 genistein increases expression ISO RGD:733473 6480464 Genistein results in increased expression of IRS1 mRNA CTD PMID:22228119 gentamycin decreases expression EXP 6480464 Gentamicins results in decreased expression of IRS1 mRNA CTD PMID:33387578 gingerol multiple interactions ISO RGD:10816 6480464 gingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS1 mRNA], gingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS1 protein] CTD PMID:22285432 ginsenoside Re multiple interactions ISO RGD:10816 6480464 ginsenoside Re inhibits the reaction [TNF protein results in increased phosphorylation of IRS1 protein] CTD PMID:17885204 ginsenoside Re increases phosphorylation ISO RGD:10816 6480464 ginsenoside Re results in increased phosphorylation of IRS1 protein CTD PMID:17885204 ginsenoside Re increases expression ISO RGD:10816 6480464 ginsenoside Re results in increased expression of IRS1 mRNA CTD PMID:23545455 Ginsenoside Rh4 multiple interactions ISO RGD:10816 6480464 ginsenoside Rh4 inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of IRS1 mRNA] CTD PMID:33359794 glucose multiple interactions ISO RGD:733473 6480464 ACACB protein affects the reaction [Glucose results in decreased phosphorylation of IRS1 protein] more ... CTD PMID:10430617 more ... glucose decreases phosphorylation ISO RGD:733473 6480464 Glucose results in decreased phosphorylation of IRS1 protein CTD PMID:33957017 glucose decreases expression ISO RGD:733473 6480464 Glucose results in decreased expression of IRS1 protein, Glucose results in decreased expression of IRS1 protein modified form CTD PMID:24262486 glucose increases phosphorylation ISO RGD:733473 6480464 Glucose results in increased phosphorylation of IRS1 protein CTD PMID:10430617 glyburide multiple interactions ISO RGD:733473 6480464 IRS1 protein polymorphism inhibits the reaction [Glyburide results in increased secretion of INS protein] CTD PMID:10430617 glyphosate decreases expression ISO RGD:733473 6480464 glyphosate results in decreased expression of IRS1 mRNA CTD PMID:31295307 hexachlorobenzene increases phosphorylation EXP 6480464 Hexachlorobenzene results in increased phosphorylation of IRS1 protein CTD PMID:16237195 hexachlorobenzene increases phosphorylation ISO RGD:733473 6480464 Hexachlorobenzene results in increased phosphorylation of IRS1 protein CTD PMID:19879930 hexachlorobenzene multiple interactions ISO RGD:733473 6480464 [Hexachlorobenzene co-treated with Estradiol] results in increased phosphorylation of IRS1 protein more ... CTD PMID:19879930 hexachlorobenzene increases expression EXP 6480464 Hexachlorobenzene results in increased expression of IRS1 protein CTD PMID:16237195 hexachlorobenzene multiple interactions EXP 6480464 Hexachlorobenzene inhibits the reaction [Methylnitrosourea results in increased phosphorylation of IRS1 protein] CTD PMID:16237195 hexadecanoic acid multiple interactions ISO RGD:733473 6480464 3 more ... CTD PMID:25815690 , PMID:30362509 hexadecanoic acid multiple interactions EXP 6480464 4-hydroxyisoleucine inhibits the reaction [Palmitic Acid inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]], Palmitic Acid inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein] CTD PMID:25109277 hydroquinone decreases expression ISO RGD:733473 6480464 hydroquinone results in decreased expression of IRS1 mRNA CTD PMID:31256213 isoprenaline increases expression ISO RGD:10816 6480464 Isoproterenol results in increased expression of IRS1 mRNA CTD PMID:20003209 ketanserin multiple interactions ISO RGD:10816 6480464 [[Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]] which results in increased ubiquitination of and results in increased degradation of IRS1 protein, [Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]] CTD PMID:22975078 L-ascorbic acid multiple interactions EXP 6480464 [Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of IRS1 protein], [Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Diethylhexyl Phthalate results in decreased phosphorylation of IRS1 protein] CTD PMID:21911000 L-methionine multiple interactions ISO RGD:10816 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of IRS1 gene CTD PMID:20938992 lead diacetate decreases expression EXP 6480464 lead acetate results in decreased expression of IRS1 mRNA CTD PMID:30980912 leflunomide decreases expression ISO RGD:10816 6480464 leflunomide results in decreased expression of IRS1 mRNA CTD PMID:19751817 leflunomide increases expression ISO RGD:733473 6480464 leflunomide results in increased expression of IRS1 mRNA CTD PMID:28988120 linsidomine multiple interactions ISO RGD:10816 6480464 linsidomine inhibits the reaction [INS1 protein results in increased phosphorylation of IRS1 protein], linsidomine results in increased metabolism of and results in decreased expression of IRS1 protein CTD PMID:19682478 lipopolysaccharide multiple interactions ISO RGD:10816 6480464 17-ethynyl-5-androstene-3 more ... CTD PMID:22384159 lipopolysaccharide multiple interactions ISO RGD:733473 6480464 [S-(1, 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of IRS1 mRNA CTD PMID:35811015 lovastatin multiple interactions ISO RGD:10816 6480464 [Dietary Fats co-treated with Lovastatin] affects the expression of IRS1 mRNA CTD PMID:29852127 LY294002 decreases phosphorylation EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of IRS1 protein CTD PMID:34455488 LY294002 multiple interactions EXP 6480464 Phosphocreatine inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of IRS1 protein] CTD PMID:34455488 melatonin multiple interactions ISO RGD:10816 6480464 Melatonin inhibits the reaction [sodium arsenite results in decreased expression of IRS1 protein] CTD PMID:29763682 mercury atom multiple interactions ISO RGD:10816 6480464 [Cadmium co-treated with Mercury] results in increased phosphorylation of IRS1 protein CTD PMID:30629257 mercury dibromide increases expression ISO RGD:733473 6480464 mercuric bromide results in increased expression of IRS1 mRNA CTD PMID:26272509 mercury dibromide multiple interactions ISO RGD:733473 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS1 mRNA CTD PMID:27188386 mercury(0) multiple interactions ISO RGD:10816 6480464 [Cadmium co-treated with Mercury] results in increased phosphorylation of IRS1 protein CTD PMID:30629257 metformin multiple interactions EXP 6480464 Metformin inhibits the reaction [Dehydroepiandrosterone results in decreased phosphorylation of IRS1 protein] CTD PMID:27634381 metformin multiple interactions ISO RGD:10816 6480464 Metformin inhibits the reaction [Streptozocin results in decreased expression of IRS1 protein], Metformin promotes the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of IRS1 protein] CTD PMID:23927877 , PMID:31743741 metformin multiple interactions ISO RGD:733473 6480464 Metformin affects the reaction [Testosterone results in decreased expression of IRS1] more ... CTD PMID:19328476 more ... methamphetamine decreases phosphorylation ISO RGD:733473 6480464 Methamphetamine results in decreased phosphorylation of IRS1 protein CTD PMID:31270305 methamphetamine multiple interactions ISO RGD:733473 6480464 Rosiglitazone inhibits the reaction [Methamphetamine results in decreased phosphorylation of IRS1 protein] CTD PMID:31270305 methamphetamine multiple interactions ISO RGD:10816 6480464 rosiglitazone inhibits the reaction [Methamphetamine results in increased phosphorylation of IRS1 protein] CTD PMID:29981415 methamphetamine increases phosphorylation ISO RGD:10816 6480464 Methamphetamine results in increased phosphorylation of IRS1 protein CTD PMID:29981415 methoxychlor increases methylation EXP 6480464 Methoxychlor results in increased methylation of IRS1 gene CTD PMID:23303685 methylglyoxal decreases phosphorylation EXP 6480464 Pyruvaldehyde results in decreased phosphorylation of IRS1 protein CTD PMID:23954466 , PMID:34455488 methylglyoxal multiple interactions EXP 6480464 Phosphocreatine inhibits the reaction [Pyruvaldehyde results in decreased phosphorylation of IRS1 protein] CTD PMID:34455488 methylmercury chloride increases expression ISO RGD:733473 6480464 methylmercuric chloride results in increased expression of IRS1 mRNA CTD PMID:23179753 more ... methylmercury chloride multiple interactions ISO RGD:10816 6480464 [Cadmium Chloride co-treated with methylmercuric chloride] results in decreased expression of IRS1 mRNA, [Cadmium Chloride co-treated with methylmercuric chloride] results in increased phosphorylation of IRS1 protein CTD PMID:27814245 , PMID:30629257 methylmercury chloride multiple interactions ISO RGD:733473 6480464 [NOG protein co-treated with methylmercuric chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS1 mRNA CTD PMID:27188386 microcystin-LR increases phosphorylation ISO RGD:733473 6480464 cyanoginosin LR results in increased phosphorylation of IRS1 protein CTD PMID:28984034 microcystin-LR increases phosphorylation ISO RGD:10816 6480464 cyanoginosin LR results in increased phosphorylation of IRS1 protein CTD PMID:31714646 , PMID:32073747 microcystin-LR decreases expression ISO RGD:10816 6480464 cyanoginosin LR results in decreased expression of IRS1 mRNA CTD PMID:29777831 microcystin-LR decreases phosphorylation ISO RGD:10816 6480464 cyanoginosin LR results in decreased phosphorylation of IRS1 protein CTD PMID:29777831 microcystin-LR multiple interactions ISO RGD:733473 6480464 cyanoginosin LR promotes the reaction [INS protein results in increased phosphorylation of IRS1 protein] more ... CTD PMID:28984034 microcystin-LR multiple interactions ISO RGD:10816 6480464 cyanoginosin LR results in decreased expression of and results in increased phosphorylation of IRS1 protein CTD PMID:28984034 miquelianin multiple interactions ISO RGD:733473 6480464 quercetin 3-O-glucuronide inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]], quercetin 3-O-glucuronide inhibits the reaction [Palmitates results in increased phosphorylation of IRS1 protein] CTD PMID:23504962 mono(2-ethylhexyl) phthalate decreases expression ISO RGD:10816 6480464 mono-(2-ethylhexyl)phthalate results in decreased expression of IRS1 mRNA, mono-(2-ethylhexyl)phthalate results in decreased expression of IRS1 protein CTD PMID:25543134 , PMID:31009676 mono(2-ethylhexyl) phthalate multiple interactions ISO RGD:10816 6480464 [INS1 protein co-treated with mono-(2-ethylhexyl)phthalate] results in decreased expression of IRS1 protein, mono-(2-ethylhexyl)phthalate inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein] CTD PMID:31009676 mono(2-ethylhexyl) phthalate multiple interactions ISO RGD:733473 6480464 [mono-(2-ethylhexyl)phthalate results in decreased activity of INS protein] which results in decreased phosphorylation of IRS1 protein more ... CTD PMID:31228551 mono(2-ethylhexyl) phthalate decreases phosphorylation ISO RGD:733473 6480464 mono-(2-ethylhexyl)phthalate results in decreased phosphorylation of IRS1 protein CTD PMID:31228551 mono(2-ethylhexyl) phthalate multiple interactions EXP 6480464 [INS1 protein co-treated with mono-(2-ethylhexyl)phthalate] results in decreased expression of IRS1 protein CTD PMID:28526321 myricetin multiple interactions EXP 6480464 myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in decreased expression of IRS1 protein] CTD PMID:24923654 N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide multiple interactions ISO RGD:10816 6480464 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IRS1 mRNA] CTD PMID:17407152 N-acetyl-L-cysteine multiple interactions ISO RGD:733473 6480464 Acetylcysteine inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of IRS1 protein] CTD PMID:17458902 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO RGD:10816 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [INS1 protein results in decreased expression of IRS1 protein], benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [triptolide results in decreased expression of IRS1 protein] CTD PMID:24219910 , PMID:32061799 N-methyl-4-phenylpyridinium decreases expression ISO RGD:733473 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of IRS1 protein CTD PMID:26364587 N-methyl-4-phenylpyridinium multiple interactions ISO RGD:733473 6480464 INS protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of IRS1 protein] CTD PMID:26364587 N-methyl-N-nitrosourea multiple interactions EXP 6480464 Hexachlorobenzene inhibits the reaction [Methylnitrosourea results in increased phosphorylation of IRS1 protein] CTD PMID:16237195 N-methyl-N-nitrosourea increases phosphorylation EXP 6480464 Methylnitrosourea results in increased phosphorylation of IRS1 protein CTD PMID:16237195 N-nitrosodiethylamine affects expression EXP 6480464 Diethylnitrosamine affects the expression of IRS1 mRNA CTD PMID:20387270 N-nitrosomorpholine increases expression EXP 6480464 N-nitrosomorpholine results in increased expression of IRS1 protein CTD PMID:21411721 , PMID:9466558 N-phosphocreatine multiple interactions EXP 6480464 Phosphocreatine inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of IRS1 protein] more ... CTD PMID:34455488 naringin multiple interactions ISO RGD:10816 6480464 naringin inhibits the reaction [Dietary Fats results in decreased phosphorylation of IRS1 protein] CTD PMID:22198281 nickel atom decreases expression ISO RGD:733473 6480464 Nickel results in decreased expression of IRS1 mRNA CTD PMID:25583101 nicotine decreases expression EXP 6480464 Nicotine results in decreased expression of IRS1 mRNA CTD PMID:22265867 oleanolic acid multiple interactions EXP 6480464 [Fructose co-treated with Oleanolic Acid] results in increased expression of IRS1 mRNA more ... CTD PMID:24704288 orientin multiple interactions ISO RGD:10816 6480464 orientin inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of IRS1 protein] CTD PMID:32044341 ozone multiple interactions EXP 6480464 Coconut Oil promotes the reaction [Ozone results in decreased expression of IRS1 mRNA] CTD PMID:33217375 ozone decreases expression EXP 6480464 Ozone results in decreased expression of IRS1 mRNA CTD PMID:33217375 paracetamol decreases expression ISO RGD:733473 6480464 Acetaminophen results in decreased expression of IRS1 mRNA CTD PMID:21420995 paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of IRS1 mRNA CTD PMID:33387578 paracetamol increases expression ISO RGD:733473 6480464 Acetaminophen results in increased expression of IRS1 mRNA CTD PMID:22230336 paraquat multiple interactions ISO RGD:10816 6480464 Paraquat results in decreased expression of and results in increased phosphorylation of IRS1 protein CTD PMID:23898955 paraquat increases phosphorylation EXP 6480464 Paraquat results in increased phosphorylation of IRS1 protein CTD PMID:36394833 paroxetine multiple interactions EXP 6480464 Paroxetine affects the reaction [INS protein affects the phosphorylation of IRS1 protein], pyrazolanthrone inhibits the reaction [Paroxetine affects the reaction [INS protein affects the phosphorylation of IRS1 protein]] CTD PMID:17728140 paroxetine decreases activity EXP 6480464 Paroxetine results in decreased activity of IRS1 protein CTD PMID:17728140 perfluorododecanoic acid decreases expression EXP 6480464 perfluorododecanoic acid results in decreased expression of IRS1 protein modified form CTD PMID:23353032 perfluorononanoic acid decreases expression EXP 6480464 perfluoro-n-nonanoic acid results in decreased expression of IRS1 protein modified form CTD PMID:22387981 perfluorooctane-1-sulfonic acid increases expression ISO RGD:10816 6480464 perfluorooctane sulfonic acid results in increased expression of IRS1 mRNA CTD PMID:26548598 perfluorooctane-1-sulfonic acid multiple interactions ISO RGD:10816 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of IRS1 mRNA CTD PMID:36331819 permethrin multiple interactions ISO RGD:733473 6480464 [Permethrin co-treated with INS protein] results in increased phosphorylation of IRS1 protein CTD PMID:28866332 phenethyl caffeate decreases expression ISO RGD:10816 6480464 caffeic acid phenethyl ester results in decreased expression of IRS1 mRNA CTD PMID:21467634 phenylmercury acetate increases expression ISO RGD:733473 6480464 Phenylmercuric Acetate results in increased expression of IRS1 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:733473 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS1 mRNA CTD PMID:27188386 phosgene affects expression ISO RGD:10816 6480464 Phosgene affects the expression of IRS1 mRNA CTD PMID:16300373 picoxystrobin decreases expression ISO RGD:733473 6480464 picoxystrobin results in decreased expression of IRS1 mRNA CTD PMID:33512557 pirinixic acid increases expression ISO RGD:10816 6480464 pirinixic acid results in increased expression of IRS1 mRNA CTD PMID:18301758 pirinixic acid decreases expression ISO RGD:10816 6480464 pirinixic acid results in decreased expression of IRS1 mRNA CTD PMID:18445702 procyanidin B1 multiple interactions ISO RGD:733473 6480464 [p-coumaric acid co-treated with procyanidin B1] results in increased expression of and results in increased phosphorylation of IRS1 protein, procyanidin B1 results in increased expression of and results in increased phosphorylation of IRS1 protein CTD PMID:34342938 procyanidin B1 multiple interactions ISO RGD:10816 6480464 [procyanidin B1 co-treated with p-coumaric acid] results in increased expression of and results in increased phosphorylation of IRS1 protein, procyanidin B1 results in increased expression of and results in increased phosphorylation of IRS1 protein CTD PMID:34342938 progesterone decreases phosphorylation ISO RGD:733473 6480464 Progesterone results in decreased phosphorylation of IRS1 protein CTD PMID:15949379 progesterone increases phosphorylation ISO RGD:10816 6480464 Progesterone results in increased phosphorylation of IRS1 protein CTD PMID:15604210 propiconazole increases expression ISO RGD:10816 6480464 propiconazole results in increased expression of IRS1 mRNA CTD PMID:21278054 propionic acid decreases phosphorylation ISO RGD:10816 6480464 propionic acid results in decreased phosphorylation of IRS1 protein CTD PMID:21472246 quercetin multiple interactions ISO RGD:733473 6480464 Quercetin affects the reaction [[Fatty Acids co-treated with INS protein] affects the phosphorylation of IRS1 protein] more ... CTD PMID:23504962 , PMID:24648896 quercetin multiple interactions ISO RGD:10816 6480464 Quercetin inhibits the reaction [IGF1 protein results in increased phosphorylation of IRS1 protein] CTD PMID:24353828 quercetin decreases expression ISO RGD:733473 6480464 Quercetin results in decreased expression of IRS1 mRNA, Quercetin results in decreased expression of IRS1 protein CTD PMID:12653748 , PMID:21632981 quercetin multiple interactions EXP 6480464 Quercetin inhibits the reaction [Dehydroepiandrosterone results in decreased phosphorylation of IRS1 protein], Quercetin inhibits the reaction [Fructose results in decreased phosphorylation of IRS1 protein] CTD PMID:22426011 , PMID:27634381 rebaudioside A multiple interactions ISO RGD:10816 6480464 rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS1 mRNA] CTD PMID:25554529 resveratrol increases phosphorylation ISO RGD:10816 6480464 resveratrol results in increased phosphorylation of IRS1 protein CTD PMID:22309033 resveratrol increases expression EXP 6480464 resveratrol results in increased expression of IRS1 mRNA, resveratrol results in increased expression of IRS1 protein CTD PMID:26071184 , PMID:26488877 resveratrol affects phosphorylation ISO RGD:10816 6480464 resveratrol affects the phosphorylation of IRS1 protein CTD PMID:20188786 resveratrol decreases phosphorylation ISO RGD:10816 6480464 resveratrol results in decreased phosphorylation of IRS1 protein CTD PMID:22935344 resveratrol decreases expression ISO RGD:10816 6480464 resveratrol results in decreased expression of IRS1 mRNA, resveratrol results in decreased expression of IRS1 protein CTD PMID:18555852 more ... resveratrol decreases expression ISO RGD:733473 6480464 resveratrol results in decreased expression of IRS1 protein CTD PMID:18089832 resveratrol multiple interactions EXP 6480464 [Fructose co-treated with resveratrol] results in increased expression of IRS1 mRNA more ... CTD PMID:16626303 more ... resveratrol multiple interactions ISO RGD:733473 6480464 Resveratrol inhibits the reaction [bisphenol A results in increased expression of IRS1 protein modified form] more ... CTD PMID:17550345 more ... rivastigmine multiple interactions EXP 6480464 Rivastigmine inhibits the reaction [Streptozocin results in decreased expression of IRS1 mRNA] CTD PMID:32805344 rutin multiple interactions EXP 6480464 Rutin inhibits the reaction [Fructose results in decreased phosphorylation of IRS1 protein] CTD PMID:22426011 rutin multiple interactions ISO RGD:733473 6480464 Rutin results in increased susceptibility to [Vitamin E results in decreased expression of IRS1 protein], Vitamin E results in increased susceptibility to [Rutin results in decreased expression of IRS1 protein] CTD PMID:20015448 rutin decreases expression ISO RGD:733473 6480464 Rutin results in decreased expression of IRS1 protein CTD PMID:20015448 S-(1,2-dichlorovinyl)-L-cysteine multiple interactions ISO RGD:733473 6480464 [S-(1, 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of IRS1 mRNA CTD PMID:35811015 S-(1,2-dichlorovinyl)-L-cysteine decreases expression ISO RGD:733473 6480464 S-(1, 2-dichlorovinyl)cysteine results in decreased expression of IRS1 mRNA CTD PMID:35811015 sarpogrelate multiple interactions ISO RGD:10816 6480464 [sarpogrelate results in increased activity of AKT1 protein] inhibits the reaction [Serotonin results in increased ubiquitination of and results in increased degradation of IRS1 protein] CTD PMID:22975078 SB 203580 multiple interactions ISO RGD:733473 6480464 SB 203580 inhibits the reaction [bisphenol A results in increased expression of IRS1 protein modified form] CTD PMID:29793316 SB 431542 multiple interactions ISO RGD:733473 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 serotonin multiple interactions ISO RGD:10816 6480464 [[Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]] which results in increased ubiquitination of and results in increased degradation of IRS1 protein more ... CTD PMID:22975078 sertraline multiple interactions EXP 6480464 Sertraline affects the reaction [INS protein affects the phosphorylation of IRS1 protein] CTD PMID:17728140 sertraline decreases activity EXP 6480464 Sertraline results in decreased activity of IRS1 protein CTD PMID:17728140 silicon dioxide decreases expression ISO RGD:10816 6480464 Silicon Dioxide results in decreased expression of IRS1 mRNA CTD PMID:23221170 simvastatin multiple interactions ISO RGD:10816 6480464 Simvastatin inhibits the reaction [IGF1 protein results in increased phosphorylation of IRS1 protein] CTD PMID:27734117 sirolimus affects phosphorylation ISO RGD:733473 6480464 Sirolimus affects the phosphorylation of IRS1 protein CTD PMID:17908691 sirolimus decreases phosphorylation ISO RGD:733473 6480464 Sirolimus results in decreased phosphorylation of IRS1 protein CTD PMID:16227402 sirolimus decreases degradation ISO RGD:733473 6480464 Sirolimus results in decreased degradation of IRS1 protein CTD PMID:16227402 , PMID:17908691 sirolimus multiple interactions ISO RGD:733473 6480464 [Sirolimus results in decreased activity of RPS6KB1 protein] which results in increased activity of IRS1 protein more ... CTD PMID:16227402 more ... sodium arsenate multiple interactions ISO RGD:733473 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of IRS1 mRNA CTD PMID:32525701 sodium arsenite decreases expression ISO RGD:733473 6480464 sodium arsenite results in decreased expression of IRS1 mRNA, sodium arsenite results in decreased expression of IRS1 protein CTD PMID:24570342 , PMID:34118311 sodium arsenite multiple interactions ISO RGD:733473 6480464 [INS protein co-treated with sodium arsenite] results in decreased expression of and results in decreased phosphorylation of IRS1 protein more ... CTD PMID:29526746 , PMID:33743404 sodium arsenite affects expression ISO RGD:10816 6480464 sodium arsenite affects the expression of IRS1 CTD PMID:25367288 sodium arsenite decreases expression ISO RGD:10816 6480464 sodium arsenite results in decreased expression of IRS1 mRNA, sodium arsenite results in decreased expression of IRS1 protein CTD PMID:22285432 , PMID:29763682 sodium arsenite multiple interactions ISO RGD:10816 6480464 [sodium arsenite results in increased abundance of arsenite] which results in decreased expression of IRS1 protein more ... CTD PMID:22285432 more ... sodium arsenite increases methylation ISO RGD:733473 6480464 sodium arsenite results in increased methylation of IRS1 gene CTD PMID:24570342 Sodium salicylate multiple interactions ISO RGD:733473 6480464 Sodium Salicylate inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]], Sodium Salicylate inhibits the reaction [Palmitates results in increased phosphorylation of IRS1 protein] CTD PMID:23504962 steviol multiple interactions ISO RGD:10816 6480464 steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS1 mRNA] CTD PMID:25554529 stevioside multiple interactions ISO RGD:10816 6480464 stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS1 mRNA] CTD PMID:25554529 streptozocin multiple interactions EXP 6480464 [Streptozocin co-treated with Cadmium] results in decreased expression of IRS1 protein more ... CTD PMID:24923654 more ... streptozocin decreases phosphorylation EXP 6480464 Streptozocin results in decreased phosphorylation of IRS1 protein CTD PMID:34455488 streptozocin decreases expression EXP 6480464 Streptozocin results in decreased expression of IRS1 mRNA, Streptozocin results in decreased expression of IRS1 protein CTD PMID:26071184 , PMID:32805344 streptozocin decreases expression ISO RGD:10816 6480464 Streptozocin results in decreased expression of IRS1 protein CTD PMID:23927877 streptozocin multiple interactions ISO RGD:10816 6480464 [Dietary Fats co-treated with Streptozocin] results in decreased expression of IRS1 mRNA more ... CTD PMID:23927877 more ... sucrose multiple interactions ISO RGD:733473 6480464 Oligosaccharides inhibits the reaction [[Sucrose co-treated with Dietary Fats] affects the expression of IRS1 mRNA], Oligosaccharides inhibits the reaction [[Sucrose co-treated with Dietary Fats] affects the expression of IRS1 protein] CTD PMID:31181236 sulpiride multiple interactions EXP 6480464 Sulpiride results in decreased expression of and results in increased phosphorylation of IRS1 protein CTD PMID:29551354 sulpiride decreases expression EXP 6480464 Sulpiride results in decreased expression of IRS1 mRNA CTD PMID:29551354 sunitinib increases expression ISO RGD:733473 6480464 Sunitinib results in increased expression of IRS1 mRNA CTD PMID:31533062 tamoxifen affects expression ISO RGD:733473 6480464 Tamoxifen affects the expression of IRS1 mRNA CTD PMID:14699072 taurine increases phosphorylation EXP 6480464 Taurine results in increased phosphorylation of IRS1 protein CTD PMID:22138235 taurine multiple interactions ISO RGD:733473 6480464 Taurine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of IRS1 protein] CTD PMID:30362509 taurine multiple interactions EXP 6480464 Taurine inhibits the reaction [Alloxan results in decreased phosphorylation of IRS1 protein] CTD PMID:22138235 temozolomide increases expression ISO RGD:733473 6480464 Temozolomide results in increased expression of IRS1 mRNA CTD PMID:31758290 Tesaglitazar decreases expression EXP 6480464 tesaglitazar results in decreased expression of IRS1 mRNA CTD PMID:21515302 testosterone multiple interactions ISO RGD:733473 6480464 Metformin affects the reaction [Testosterone results in decreased expression of IRS1] CTD PMID:19328476 testosterone multiple interactions EXP 6480464 Testosterone inhibits the reaction [Dexamethasone results in decreased expression of IRS1 mRNA] CTD PMID:20032058 testosterone decreases expression ISO RGD:733473 6480464 Testosterone results in decreased expression of IRS1 CTD PMID:19328476 tetrachloromethane affects expression ISO RGD:10816 6480464 Carbon Tetrachloride affects the expression of IRS1 mRNA CTD PMID:17484886 tetrachloromethane decreases expression ISO RGD:10816 6480464 Carbon Tetrachloride results in decreased expression of IRS1 mRNA CTD PMID:31919559 thapsigargin multiple interactions ISO RGD:733473 6480464 Thapsigargin affects the phosphorylation of and results in decreased expression of IRS1 protein CTD PMID:22378314 theophylline increases expression ISO RGD:733473 6480464 Theophylline results in increased expression of IRS1 mRNA CTD PMID:16083514 thymoquinone multiple interactions EXP 6480464 thymoquinone inhibits the reaction [bisphenol A results in decreased phosphorylation of IRS1 protein] CTD PMID:33315269 Tiron multiple interactions ISO RGD:733473 6480464 1 more ... CTD PMID:17458902 titanium dioxide decreases expression ISO RGD:10816 6480464 titanium dioxide results in decreased expression of IRS1 mRNA CTD PMID:23557971 , PMID:27760801 titanium dioxide multiple interactions ISO RGD:10816 6480464 4-phenylbutyric acid inhibits the reaction [titanium dioxide results in increased phosphorylation of IRS1 protein], [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of IRS1 mRNA CTD PMID:29950665 , PMID:31298478 titanium dioxide increases phosphorylation ISO RGD:10816 6480464 titanium dioxide results in increased phosphorylation of IRS1 protein CTD PMID:31298478 , PMID:31769605 tributylstannane multiple interactions ISO RGD:10816 6480464 tributyltin results in decreased expression of and results in decreased phosphorylation of IRS1 protein CTD PMID:28397090 tributylstannane increases expression ISO RGD:10816 6480464 tributyltin results in increased expression of IRS1 mRNA CTD PMID:30027469 trichloroethene decreases expression ISO RGD:10816 6480464 Trichloroethylene results in decreased expression of IRS1 mRNA CTD PMID:28973375 trichloroethene increases expression EXP 6480464 Trichloroethylene results in increased expression of IRS1 mRNA CTD PMID:33387578 trichostatin A increases expression ISO RGD:733473 6480464 trichostatin A results in increased expression of IRS1 mRNA CTD PMID:24935251 , PMID:26272509 trichostatin A multiple interactions ISO RGD:733473 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS1 mRNA CTD PMID:27188386 trimellitic anhydride decreases expression ISO RGD:10816 6480464 trimellitic anhydride results in decreased expression of IRS1 mRNA CTD PMID:19042947 triphenyl phosphate increases expression ISO RGD:10816 6480464 triphenyl phosphate results in increased expression of IRS1 mRNA CTD PMID:29316351 Triptolide increases degradation ISO RGD:10816 6480464 triptolide results in increased degradation of IRS1 protein CTD PMID:32061799 Triptolide multiple interactions ISO RGD:10816 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [triptolide results in decreased expression of IRS1 protein], triptolide results in decreased expression of and results in decreased phosphorylation of IRS1 protein CTD PMID:32061799 tris(picolinato)chromium multiple interactions EXP 6480464 chromium tripicolinate promotes the reaction [INS1 protein results in increased phosphorylation of IRS1 protein] CTD PMID:16424121 troglitazone decreases expression EXP 6480464 troglitazone results in decreased expression of IRS1 mRNA CTD PMID:21515302 tunicamycin multiple interactions ISO RGD:733473 6480464 Tunicamycin affects the phosphorylation of and results in decreased expression of IRS1 protein CTD PMID:22378314 urethane decreases expression ISO RGD:733473 6480464 Urethane results in decreased expression of IRS1 mRNA CTD PMID:28818685 valproic acid multiple interactions ISO RGD:733473 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS1 mRNA CTD PMID:27188386 valproic acid increases expression ISO RGD:733473 6480464 Valproic Acid results in increased expression of IRS1 mRNA CTD PMID:23179753 more ... vancomycin increases expression ISO RGD:10816 6480464 Vancomycin results in increased expression of IRS1 mRNA CTD PMID:18930951 vitamin E multiple interactions ISO RGD:733473 6480464 Rutin results in increased susceptibility to [Vitamin E results in decreased expression of IRS1 protein], Vitamin E results in increased susceptibility to [Rutin results in decreased expression of IRS1 protein] CTD PMID:20015448 vitamin E decreases expression ISO RGD:733473 6480464 Vitamin E results in decreased expression of IRS1 protein CTD PMID:20015448 vitamin E multiple interactions EXP 6480464 [Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of IRS1 protein], [Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Diethylhexyl Phthalate results in decreased phosphorylation of IRS1 protein] CTD PMID:21911000 wortmannin multiple interactions ISO RGD:733473 6480464 wortmannin inhibits the reaction [INS protein results in increased expression of IRS1 protein modified form] CTD PMID:20936651 wortmannin multiple interactions EXP 6480464 Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in decreased expression of IRS1 mRNA]] CTD PMID:32805344 zinc atom decreases expression ISO RGD:733473 6480464 Zinc results in decreased expression of IRS1 protein CTD PMID:19913001 zinc atom increases phosphorylation EXP 6480464 Zinc results in increased phosphorylation of IRS1 protein CTD PMID:14644152 zinc atom increases phosphorylation ISO RGD:10816 6480464 Zinc results in increased phosphorylation of IRS1 protein CTD PMID:15516700 zinc(0) decreases expression ISO RGD:733473 6480464 Zinc results in decreased expression of IRS1 protein CTD PMID:19913001 zinc(0) increases phosphorylation ISO RGD:10816 6480464 Zinc results in increased phosphorylation of IRS1 protein CTD PMID:15516700 zinc(0) increases phosphorylation EXP 6480464 Zinc results in increased phosphorylation of IRS1 protein CTD PMID:14644152
