(+)-catechin multiple interactions ISO IRS1 (Homo sapiens) 6480464 Catechin inhibits the reaction [Glucose results in decreased expression of IRS1 protein modified form] and Catechin inhibits the reaction [Glucose results in decreased expression of IRS1 protein] CTD PMID:24262486 (1->4)-beta-D-glucan multiple interactions ISO Irs1 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of IRS1 mRNA CTD PMID:36331819 (S)-nicotine decreases expression EXP 6480464 Nicotine results in decreased expression of IRS1 mRNA CTD PMID:22265867 (Z)-ligustilide decreases phosphorylation ISO IRS1 (Homo sapiens) 6480464 ligustilide results in decreased phosphorylation of IRS1 protein CTD PMID:23973442 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of IRS1 mRNA CTD PMID:29097150 17beta-estradiol decreases expression EXP 6480464 Estradiol results in decreased expression of IRS1 protein CTD PMID:22142692 17beta-estradiol affects expression EXP 6480464 Estradiol affects the expression of IRS1 mRNA CTD PMID:32145629 17beta-estradiol multiple interactions EXP 6480464 [bisphenol A co-treated with Estradiol] results in increased expression of IRS1 mRNA CTD PMID:26496021 17beta-estradiol increases phosphorylation ISO IRS1 (Homo sapiens) 6480464 Estradiol results in increased phosphorylation of IRS1 protein CTD PMID:23933164 17beta-estradiol increases expression ISO IRS1 (Homo sapiens) 6480464 Estradiol results in increased expression of IRS1 mRNA and Estradiol results in increased expression of IRS1 protein modified form CTD PMID:15072547 more ... 17beta-estradiol increases phosphorylation ISO Irs1 (Mus musculus) 6480464 Estradiol results in increased phosphorylation of IRS1 protein CTD PMID:15604210 17beta-estradiol decreases phosphorylation ISO IRS1 (Homo sapiens) 6480464 Estradiol results in decreased phosphorylation of IRS1 protein CTD PMID:15949379 17beta-estradiol multiple interactions ISO IRS1 (Homo sapiens) 6480464 1 more ... CTD PMID:15072547 more ... 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Irs1 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO IRS1 (Homo sapiens) 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of IRS1 mRNA and Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of IRS1 mRNA] CTD PMID:15688983 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 Tetrachlorodibenzodioxin inhibits the reaction [IGF1 protein results in increased phosphorylation of IRS1 protein] CTD PMID:23639626 2,3,7,8-tetrachlorodibenzodioxine decreases phosphorylation EXP 6480464 Tetrachlorodibenzodioxin results in decreased phosphorylation of IRS1 protein CTD PMID:23639626 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of IRS1 mRNA CTD PMID:20959002 more ... 2,3,7,8-tetrachlorodibenzodioxine increases phosphorylation ISO IRS1 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin results in increased phosphorylation of IRS1 protein CTD PMID:9683191 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO IRS1 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin results in increased expression of IRS1 mRNA CTD PMID:21632981 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Irs1 (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of IRS1 mRNA and Tetrachlorodibenzodioxin results in decreased expression of IRS1 protein CTD PMID:18691609 more ... 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Irs1 (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in increased expression of IRS1 mRNA CTD PMID:17407152 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Irs1 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:17407152 more ... 2,3,7,8-Tetrachlorodibenzofuran decreases expression EXP 6480464 2 more ... CTD PMID:32109520 2,4-dinitrotoluene affects expression EXP 6480464 2 and 4-dinitrotoluene affects the expression of IRS1 mRNA CTD PMID:21346803 3,3',4,4',5-pentachlorobiphenyl decreases expression EXP 6480464 3 more ... CTD PMID:20959002 3,3',4,4',5-pentachlorobiphenyl decreases expression ISO IRS1 (Homo sapiens) 6480464 3 more ... CTD PMID:35618242 3,3',4,4',5-pentachlorobiphenyl increases expression ISO Irs1 (Mus musculus) 6480464 3 more ... CTD PMID:37080397 3,3',5,5'-tetrabromobisphenol A increases expression ISO Irs1 (Mus musculus) 6480464 tetrabromobisphenol A results in increased expression of IRS1 mRNA CTD PMID:30496566 3,4-methylenedioxymethamphetamine decreases expression ISO Irs1 (Mus musculus) 6480464 N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of IRS1 mRNA CTD PMID:26251327 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO Irs1 (Mus musculus) 6480464 3 more ... CTD PMID:22298784 3-methyladenine multiple interactions ISO IRS1 (Homo sapiens) 6480464 3-methyladenine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of IRS1 protein] CTD PMID:30362509 3-methylcholanthrene decreases expression ISO Irs1 (Mus musculus) 6480464 Methylcholanthrene results in decreased expression of IRS1 mRNA CTD PMID:29554273 4,4'-sulfonyldiphenol increases expression ISO Irs1 (Mus musculus) 6480464 bisphenol S results in increased expression of IRS1 mRNA CTD PMID:33297965 4,4'-sulfonyldiphenol increases methylation ISO IRS1 (Homo sapiens) 6480464 bisphenol S results in increased methylation of IRS1 gene CTD PMID:31601247 4-nitrophenol decreases expression ISO Irs1 (Mus musculus) 6480464 4-nitrophenol results in decreased expression of IRS1 mRNA CTD PMID:34673133 4-phenylbutyric acid multiple interactions ISO Irs1 (Mus musculus) 6480464 4-phenylbutyric acid inhibits the reaction [titanium dioxide results in increased phosphorylation of IRS1 protein] CTD PMID:31298478 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of IRS1 mRNA CTD PMID:30047161 8-Br-cAMP increases expression ISO IRS1 (Homo sapiens) 6480464 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of IRS1 mRNA CTD PMID:22079614 9-cis,11-trans-octadecadienoic acid multiple interactions ISO Irs1 (Mus musculus) 6480464 cis-9 and trans-11-conjugated linoleic acid inhibits the reaction [TNF protein results in decreased expression of IRS1 mRNA] CTD PMID:17327424 9-cis,11-trans-octadecadienoic acid multiple interactions EXP 6480464 [trans-10 more ... CTD PMID:17408517 acetylsalicylic acid affects response to substance ISO IRS1 (Homo sapiens) 6480464 IRS1 polymorphism affects the susceptibility to Aspirin CTD PMID:15066917 acrylamide decreases expression EXP 6480464 Acrylamide results in decreased expression of IRS1 mRNA CTD PMID:28959563 and PMID:31644924 afimoxifene increases expression ISO IRS1 (Homo sapiens) 6480464 afimoxifene results in increased expression of IRS1 mRNA CTD PMID:15072547 aflatoxin B1 decreases methylation ISO IRS1 (Homo sapiens) 6480464 Aflatoxin B1 results in decreased methylation of IRS1 gene CTD PMID:27153756 aflatoxin B1 decreases expression ISO IRS1 (Homo sapiens) 6480464 Aflatoxin B1 results in decreased expression of IRS1 mRNA CTD PMID:22100608 more ... aldehydo-D-glucose multiple interactions ISO IRS1 (Homo sapiens) 6480464 ACACB protein affects the reaction [Glucose results in decreased phosphorylation of IRS1 protein] more ... CTD PMID:10430617 more ... aldehydo-D-glucose decreases phosphorylation ISO IRS1 (Homo sapiens) 6480464 Glucose results in decreased phosphorylation of IRS1 protein CTD PMID:33957017 aldehydo-D-glucose decreases expression ISO IRS1 (Homo sapiens) 6480464 Glucose results in decreased expression of IRS1 protein and Glucose results in decreased expression of IRS1 protein modified form CTD PMID:24262486 aldehydo-D-glucose increases phosphorylation ISO IRS1 (Homo sapiens) 6480464 Glucose results in increased phosphorylation of IRS1 protein CTD PMID:10430617 all-trans-retinoic acid decreases expression ISO IRS1 (Homo sapiens) 6480464 Tretinoin results in decreased expression of IRS1 mRNA CTD PMID:23724009 allopurinol multiple interactions EXP 6480464 Allopurinol inhibits the reaction [Fructose results in decreased phosphorylation of IRS1 protein] CTD PMID:22426011 alloxan affects phosphorylation ISO Irs1 (Mus musculus) 6480464 Alloxan affects the phosphorylation of IRS1 protein CTD PMID:26827782 alloxan multiple interactions ISO Irs1 (Mus musculus) 6480464 Phycocyanin inhibits the reaction [Alloxan affects the phosphorylation of IRS1 protein] CTD PMID:26827782 alloxan decreases phosphorylation EXP 6480464 Alloxan results in decreased phosphorylation of IRS1 protein CTD PMID:22138235 alloxan multiple interactions EXP 6480464 Taurine inhibits the reaction [Alloxan results in decreased phosphorylation of IRS1 protein] CTD PMID:22138235 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of IRS1 mRNA CTD PMID:16483693 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions EXP 6480464 pyrazolanthrone inhibits the reaction [Paroxetine affects the reaction [INS protein affects the phosphorylation of IRS1 protein]] CTD PMID:17728140 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO IRS1 (Homo sapiens) 6480464 pyrazolanthrone inhibits the reaction [bisphenol A results in increased expression of IRS1 protein modified form] CTD PMID:29793316 antirheumatic drug increases expression ISO IRS1 (Homo sapiens) 6480464 Antirheumatic Agents results in increased expression of IRS1 mRNA CTD PMID:24449571 arsane multiple interactions ISO IRS1 (Homo sapiens) 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of IRS1 mRNA CTD PMID:32525701 arsenic atom multiple interactions ISO IRS1 (Homo sapiens) 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of IRS1 mRNA CTD PMID:32525701 arsenite(3-) decreases methylation ISO IRS1 (Homo sapiens) 6480464 arsenite results in decreased methylation of IRS1 promoter CTD PMID:23974009 arsenite(3-) multiple interactions ISO Irs1 (Mus musculus) 6480464 [sodium arsenite results in increased abundance of arsenite] which results in decreased expression of IRS1 protein CTD PMID:35090851 arsenite(3-) multiple interactions ISO IRS1 (Homo sapiens) 6480464 Fulvestrant inhibits the reaction [arsenite results in increased expression of IRS1 mRNA] CTD PMID:31646340 arsenite(3-) increases expression ISO IRS1 (Homo sapiens) 6480464 arsenite results in increased expression of IRS1 mRNA CTD PMID:31646340 arsenite(3-) decreases expression ISO IRS1 (Homo sapiens) 6480464 arsenite results in decreased expression of IRS1 mRNA CTD PMID:31935557 arsenous acid increases phosphorylation ISO IRS1 (Homo sapiens) 6480464 Arsenic Trioxide results in increased phosphorylation of IRS1 protein CTD PMID:30362509 arsenous acid decreases expression ISO IRS1 (Homo sapiens) 6480464 Arsenic Trioxide results in decreased expression of IRS1 mRNA CTD PMID:20458559 arsenous acid affects response to substance ISO IRS1 (Homo sapiens) 6480464 IRS1 mRNA affects the susceptibility to Arsenic Trioxide CTD PMID:23911876 arsenous acid multiple interactions ISO IRS1 (Homo sapiens) 6480464 3-methyladenine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of IRS1 protein] more ... CTD PMID:30362509 atrazine affects phosphorylation ISO IRS1 (Homo sapiens) 6480464 Atrazine affects the phosphorylation of IRS1 protein CTD PMID:22378314 atrazine decreases expression EXP 6480464 Atrazine results in decreased expression of IRS1 mRNA CTD PMID:36841081 azathioprine multiple interactions ISO IRS1 (Homo sapiens) 6480464 Azathioprine results in increased phosphorylation of and results in decreased expression of IRS1 protein CTD PMID:23958494 benzo[a]pyrene increases expression ISO Irs1 (Mus musculus) 6480464 Benzo(a)pyrene results in increased expression of IRS1 mRNA CTD PMID:19770486 benzo[a]pyrene increases methylation ISO IRS1 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased methylation of IRS1 promoter CTD PMID:27901495 benzo[a]pyrene affects methylation ISO IRS1 (Homo sapiens) 6480464 Benzo(a)pyrene affects the methylation of IRS1 3' UTR and Benzo(a)pyrene affects the methylation of IRS1 exon CTD PMID:27901495 benzo[a]pyrene decreases expression ISO IRS1 (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased expression of IRS1 mRNA CTD PMID:26238291 benzo[a]pyrene increases phosphorylation ISO IRS1 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased phosphorylation of IRS1 protein CTD PMID:9683191 benzo[a]pyrene increases expression ISO IRS1 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased expression of IRS1 mRNA CTD PMID:21632981 benzo[a]pyrene decreases expression ISO Irs1 (Mus musculus) 6480464 Benzo(a)pyrene results in decreased expression of IRS1 mRNA CTD PMID:21569818 benzo[a]pyrene diol epoxide I affects expression ISO IRS1 (Homo sapiens) 6480464 7 more ... CTD PMID:20382639 biotin multiple interactions EXP 6480464 [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride affects the phosphorylation of IRS1 protein] and Biotin inhibits the reaction [Aluminum Chloride affects the phosphorylation of IRS1 protein] CTD PMID:32383521 bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 [Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of IRS1 protein] more ... CTD PMID:21911000 more ... bis(2-ethylhexyl) phthalate multiple interactions ISO Irs1 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 and PMID:33484791 bis(2-ethylhexyl) phthalate increases phosphorylation ISO Irs1 (Mus musculus) 6480464 Diethylhexyl Phthalate results in increased phosphorylation of IRS1 protein CTD PMID:33484791 bis(2-ethylhexyl) phthalate affects phosphorylation EXP 6480464 Diethylhexyl Phthalate affects the phosphorylation of IRS1 protein CTD PMID:25280772 bis(2-ethylhexyl) phthalate decreases phosphorylation EXP 6480464 Diethylhexyl Phthalate results in decreased phosphorylation of IRS1 protein CTD PMID:21911000 bis(2-ethylhexyl) phthalate increases expression EXP 6480464 Diethylhexyl Phthalate results in increased expression of IRS1 mRNA CTD PMID:21911000 bis(2-ethylhexyl) phthalate decreases expression EXP 6480464 Diethylhexyl Phthalate results in decreased expression of IRS1 protein CTD PMID:21911000 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of IRS1 mRNA and bisphenol A results in decreased expression of IRS1 protein CTD PMID:22142692 more ... bisphenol A increases phosphorylation EXP 6480464 bisphenol A results in increased phosphorylation of IRS1 protein CTD PMID:34973380 bisphenol A decreases phosphorylation EXP 6480464 bisphenol A results in decreased phosphorylation of IRS1 protein CTD PMID:28153594 and PMID:33315269 bisphenol A multiple interactions ISO Irs1 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of IRS1 mRNA and bisphenol A results in increased expression of IRS1 protein CTD PMID:27836638 and PMID:33296240 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of IRS1 mRNA CTD PMID:25181051 bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with Estradiol] results in increased expression of IRS1 mRNA more ... CTD PMID:26496021 more ... bisphenol A increases phosphorylation ISO Irs1 (Mus musculus) 6480464 bisphenol A results in increased phosphorylation of IRS1 protein CTD PMID:26779933 and PMID:26923231 bisphenol A decreases phosphorylation ISO Irs1 (Mus musculus) 6480464 bisphenol A results in decreased phosphorylation of IRS1 protein CTD PMID:25637671 more ... bisphenol A decreases expression ISO Irs1 (Mus musculus) 6480464 bisphenol A results in decreased expression of IRS1 mRNA CTD PMID:26779933 and PMID:35489422 bisphenol A increases phosphorylation ISO IRS1 (Homo sapiens) 6480464 bisphenol A results in increased phosphorylation of IRS1 protein CTD PMID:23933164 bisphenol A multiple interactions ISO IRS1 (Homo sapiens) 6480464 Curcumin inhibits the reaction [bisphenol A results in increased expression of IRS1 protein modified form] more ... CTD PMID:23810794 more ... bisphenol A increases expression ISO Irs1 (Mus musculus) 6480464 bisphenol A results in increased expression of IRS1 protein CTD PMID:22470480 bisphenol A increases expression ISO IRS1 (Homo sapiens) 6480464 bisphenol A results in increased expression of IRS1 mRNA and bisphenol A results in increased expression of IRS1 protein modified form CTD PMID:16029874 more ... bisphenol F increases expression ISO Irs1 (Mus musculus) 6480464 bisphenol F results in increased expression of IRS1 mRNA CTD PMID:30951980 bortezomib decreases degradation ISO IRS1 (Homo sapiens) 6480464 Bortezomib results in decreased degradation of IRS1 protein CTD PMID:16227402 buta-1,3-diene decreases expression ISO Irs1 (Mus musculus) 6480464 1 and 3-butadiene results in decreased expression of IRS1 mRNA CTD PMID:29038090 Butylbenzyl phthalate decreases expression ISO Irs1 (Mus musculus) 6480464 butylbenzyl phthalate results in decreased expression of IRS1 mRNA CTD PMID:33395283 cadmium atom multiple interactions EXP 6480464 [Streptozocin co-treated with Cadmium] results in decreased expression of IRS1 protein and myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in decreased expression of IRS1 protein] CTD PMID:24923654 cadmium atom increases expression ISO IRS1 (Homo sapiens) 6480464 Cadmium results in increased expression of IRS1 mRNA CTD PMID:31646340 cadmium atom multiple interactions ISO Irs1 (Mus musculus) 6480464 [Cadmium co-treated with Mercury] results in increased phosphorylation of IRS1 protein CTD PMID:30629257 cadmium dichloride increases expression ISO Irs1 (Mus musculus) 6480464 Cadmium Chloride results in increased expression of IRS1 mRNA CTD PMID:29572893 cadmium dichloride decreases expression ISO IRS1 (Homo sapiens) 6480464 Cadmium Chloride results in decreased expression of IRS1 mRNA CTD PMID:33129824 cadmium dichloride multiple interactions ISO Irs1 (Mus musculus) 6480464 [Cadmium Chloride co-treated with methylmercuric chloride] results in decreased expression of IRS1 mRNA and [Cadmium Chloride co-treated with methylmercuric chloride] results in increased phosphorylation of IRS1 protein CTD PMID:27814245 and PMID:30629257 caffeine affects phosphorylation ISO IRS1 (Homo sapiens) 6480464 Caffeine affects the phosphorylation of IRS1 protein CTD PMID:35688186 calcitriol increases expression ISO IRS1 (Homo sapiens) 6480464 Calcitriol results in increased expression of IRS1 mRNA CTD PMID:16002434 and PMID:26485663 cannabidiol multiple interactions ISO IRS1 (Homo sapiens) 6480464 [Cannabidiol co-treated with moringin] results in decreased expression of IRS1 mRNA CTD PMID:30096889 capsaicin increases expression ISO Irs1 (Mus musculus) 6480464 Capsaicin results in increased expression of IRS1 mRNA CTD PMID:19798065 carbamazepine affects expression ISO IRS1 (Homo sapiens) 6480464 Carbamazepine affects the expression of IRS1 mRNA CTD PMID:24752500 carbon nanotube decreases expression ISO Irs1 (Mus musculus) 6480464 Nanotubes more ... CTD PMID:25554681 and PMID:25620056 carmustine decreases expression ISO IRS1 (Homo sapiens) 6480464 Carmustine results in decreased expression of IRS1 mRNA CTD PMID:15980968 chloroprene decreases expression ISO Irs1 (Mus musculus) 6480464 Chloroprene results in decreased expression of IRS1 mRNA CTD PMID:23125180 chlorpyrifos multiple interactions EXP 6480464 Chlorpyrifos inhibits the reaction [INS1 protein results in increased phosphorylation of IRS1 protein] CTD PMID:30918868 cholesterol affects abundance ISO IRS1 (Homo sapiens) 6480464 IRS1 gene polymorphism affects the abundance of Cholesterol CTD PMID:10591678 choline multiple interactions ISO Irs1 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of IRS1 gene CTD PMID:20938992 chromium atom increases phosphorylation ISO Irs1 (Mus musculus) 6480464 Chromium results in increased phosphorylation of IRS1 protein CTD PMID:15516700 chromium atom multiple interactions EXP 6480464 Chromium promotes the reaction [INS1 protein results in increased phosphorylation of IRS1 protein] CTD PMID:16424121 chromium atom multiple interactions ISO Irs1 (Mus musculus) 6480464 Chromium inhibits the reaction [Dietary Fats results in decreased expression of IRS1 protein] CTD PMID:20513351 chromium atom affects expression EXP 6480464 Chromium affects the expression of IRS1 mRNA CTD PMID:15862035 chromium(6+) multiple interactions ISO IRS1 (Homo sapiens) 6480464 MIR143 inhibits the reaction [chromium hexavalent ion results in increased expression of IRS1 protein] CTD PMID:23748240 chromium(6+) multiple interactions EXP 6480464 chromium hexavalent ion results in decreased expression of and results in decreased phosphorylation of IRS1 protein CTD PMID:28911802 chromium(6+) increases expression ISO IRS1 (Homo sapiens) 6480464 chromium hexavalent ion results in increased expression of IRS1 protein CTD PMID:23748240 cisplatin increases expression ISO Irs1 (Mus musculus) 6480464 Cisplatin results in increased expression of IRS1 mRNA CTD PMID:21151649 cisplatin decreases response to substance ISO IRS1 (Homo sapiens) 6480464 IRS1 results in decreased susceptibility to Cisplatin CTD PMID:21849418 cisplatin decreases expression ISO IRS1 (Homo sapiens) 6480464 Cisplatin results in decreased expression of IRS1 mRNA CTD PMID:19561079 and PMID:27392435 cobalt dichloride decreases expression ISO IRS1 (Homo sapiens) 6480464 cobaltous chloride results in decreased expression of IRS1 mRNA CTD PMID:19376846 coenzyme Q10 multiple interactions EXP 6480464 [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride affects the phosphorylation of IRS1 protein] and coenzyme Q10 inhibits the reaction [Aluminum Chloride affects the phosphorylation of IRS1 protein] CTD PMID:32383521 colforsin daropate hydrochloride multiple interactions ISO Irs1 (Mus musculus) 6480464 Colforsin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IRS1 mRNA] CTD PMID:17407152 copper atom multiple interactions ISO IRS1 (Homo sapiens) 6480464 [Chelating Agents binds to Copper] which results in decreased expression of IRS1 mRNA CTD PMID:30911355 copper(0) multiple interactions ISO IRS1 (Homo sapiens) 6480464 [Chelating Agents binds to Copper] which results in decreased expression of IRS1 mRNA CTD PMID:30911355 copper(II) sulfate increases expression ISO IRS1 (Homo sapiens) 6480464 Copper Sulfate results in increased expression of IRS1 mRNA CTD PMID:19549813 coumarin affects phosphorylation ISO IRS1 (Homo sapiens) 6480464 coumarin affects the phosphorylation of IRS1 protein CTD PMID:35688186 coumestrol multiple interactions ISO IRS1 (Homo sapiens) 6480464 [Coumestrol co-treated with ESR1 protein] results in increased expression of IRS1 mRNA and ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of IRS1 mRNA] CTD PMID:18310284 CU-O LINKAGE decreases expression ISO IRS1 (Homo sapiens) 6480464 cupric oxide results in decreased expression of IRS1 mRNA CTD PMID:22077320 curcumin multiple interactions EXP 6480464 Curcumin inhibits the reaction [Fructose affects the phosphorylation of IRS1 protein] CTD PMID:26713546 curcumin multiple interactions ISO IRS1 (Homo sapiens) 6480464 Curcumin inhibits the reaction [bisphenol A results in increased expression of IRS1 protein modified form] CTD PMID:29793316 curcumin affects phosphorylation ISO Irs1 (Mus musculus) 6480464 Curcumin affects the phosphorylation of IRS1 protein CTD PMID:27208389 cycloheximide decreases expression ISO IRS1 (Homo sapiens) 6480464 Cycloheximide results in decreased expression of IRS1 mRNA CTD PMID:15072547 cycloheximide multiple interactions ISO IRS1 (Homo sapiens) 6480464 [Cycloheximide co-treated with Estradiol] results in increased expression of IRS1 mRNA CTD PMID:15072547 cyclophosphamide multiple interactions ISO IRS1 (Homo sapiens) 6480464 [Doxorubicin co-treated with Cyclophosphamide] affects the expression of IRS1 mRNA CTD PMID:16322899 cyclosporin A decreases expression ISO IRS1 (Homo sapiens) 6480464 Cyclosporine results in decreased expression of IRS1 mRNA CTD PMID:20106945 cyclosporin A decreases expression ISO Irs1 (Mus musculus) 6480464 Cyclosporine results in decreased expression of IRS1 mRNA CTD PMID:19770486 cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of IRS1 mRNA CTD PMID:21865292 D-glucose multiple interactions ISO IRS1 (Homo sapiens) 6480464 ACACB protein affects the reaction [Glucose results in decreased phosphorylation of IRS1 protein] more ... CTD PMID:10430617 more ... D-glucose decreases phosphorylation ISO IRS1 (Homo sapiens) 6480464 Glucose results in decreased phosphorylation of IRS1 protein CTD PMID:33957017 D-glucose decreases expression ISO IRS1 (Homo sapiens) 6480464 Glucose results in decreased expression of IRS1 protein and Glucose results in decreased expression of IRS1 protein modified form CTD PMID:24262486 D-glucose increases phosphorylation ISO IRS1 (Homo sapiens) 6480464 Glucose results in increased phosphorylation of IRS1 protein CTD PMID:10430617 decabromodiphenyl ether increases expression ISO Irs1 (Mus musculus) 6480464 decabromobiphenyl ether results in increased expression of IRS1 protein modified form CTD PMID:30743236 dehydroepiandrosterone decreases phosphorylation EXP 6480464 Dehydroepiandrosterone results in decreased phosphorylation of IRS1 protein CTD PMID:27634381 dehydroepiandrosterone multiple interactions EXP 6480464 Metformin inhibits the reaction [Dehydroepiandrosterone results in decreased phosphorylation of IRS1 protein] and Quercetin inhibits the reaction [Dehydroepiandrosterone results in decreased phosphorylation of IRS1 protein] CTD PMID:27634381 dexamethasone multiple interactions ISO Irs1 (Mus musculus) 6480464 3 more ... CTD PMID:18812026 more ... dexamethasone decreases expression ISO IRS1 (Homo sapiens) 6480464 Dexamethasone results in decreased expression of IRS1 mRNA CTD PMID:32976960 dexamethasone affects expression ISO IRS1 (Homo sapiens) 6480464 Dexamethasone affects the expression of IRS1 mRNA and Dexamethasone affects the expression of IRS1 protein CTD PMID:31181236 dexamethasone multiple interactions EXP 6480464 Testosterone inhibits the reaction [Dexamethasone results in decreased expression of IRS1 mRNA] CTD PMID:20032058 dexamethasone decreases expression EXP 6480464 Dexamethasone results in decreased expression of IRS1 mRNA and Dexamethasone results in decreased expression of IRS1 protein CTD PMID:20032058 and PMID:35148621 dexamethasone decreases expression ISO Irs1 (Mus musculus) 6480464 Dexamethasone results in decreased expression of IRS1 mRNA CTD PMID:18812026 dextran sulfate multiple interactions ISO Irs1 (Mus musculus) 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of IRS1 mRNA CTD PMID:29950665 diarsenic trioxide multiple interactions ISO IRS1 (Homo sapiens) 6480464 3-methyladenine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of IRS1 protein] more ... CTD PMID:30362509 diarsenic trioxide increases phosphorylation ISO IRS1 (Homo sapiens) 6480464 Arsenic Trioxide results in increased phosphorylation of IRS1 protein CTD PMID:30362509 diarsenic trioxide decreases expression ISO IRS1 (Homo sapiens) 6480464 Arsenic Trioxide results in decreased expression of IRS1 mRNA CTD PMID:20458559 diarsenic trioxide affects response to substance ISO IRS1 (Homo sapiens) 6480464 IRS1 mRNA affects the susceptibility to Arsenic Trioxide CTD PMID:23911876 dibenz[a,h]anthracene decreases expression ISO Irs1 (Mus musculus) 6480464 1 more ... CTD PMID:26377693 diclofenac affects expression ISO IRS1 (Homo sapiens) 6480464 Diclofenac affects the expression of IRS1 mRNA CTD PMID:24752500 diclofenac affects expression ISO Irs1 (Mus musculus) 6480464 Diclofenac affects the expression of IRS1 mRNA CTD PMID:26934552 dicrotophos increases expression ISO IRS1 (Homo sapiens) 6480464 dicrotophos results in increased expression of IRS1 mRNA CTD PMID:28302478 Didymin multiple interactions ISO IRS1 (Homo sapiens) 6480464 didymin inhibits the reaction [INS protein results in decreased phosphorylation of IRS1 protein] CTD PMID:30928401 dioxygen multiple interactions ISO Irs1 (Mus musculus) 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of IRS1 mRNA CTD PMID:30529165 disodium selenite multiple interactions ISO Irs1 (Mus musculus) 6480464 Sodium Selenite promotes the reaction [[Streptozocin co-treated with Dietary Fats] affects the phosphorylation of IRS1 protein] CTD PMID:26522834 dorsomorphin multiple interactions ISO IRS1 (Homo sapiens) 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin multiple interactions ISO IRS1 (Homo sapiens) 6480464 [Doxorubicin co-treated with Cyclophosphamide] affects the expression of IRS1 mRNA CTD PMID:16322899 doxorubicin increases expression ISO IRS1 (Homo sapiens) 6480464 Doxorubicin results in increased expression of IRS1 mRNA CTD PMID:37062353 doxorubicin decreases expression ISO IRS1 (Homo sapiens) 6480464 Doxorubicin results in decreased expression of IRS1 mRNA CTD PMID:29803840 ethanol decreases phosphorylation EXP 6480464 Ethanol results in decreased phosphorylation of IRS1 protein CTD PMID:12700235 ethanol multiple interactions ISO Irs1 (Mus musculus) 6480464 [lard co-treated with Ethanol co-treated with High Fructose Corn Syrup] results in decreased phosphorylation of IRS1 protein and m-trifluoromethyl-diphenyl diselenide inhibits the reaction [[lard co-treated with Ethanol co-treated with High Fructose Corn Syrup] results in decreased phosphorylation of IRS1 protein] CTD PMID:37023972 ethanol decreases phosphorylation ISO Irs1 (Mus musculus) 6480464 Ethanol results in decreased phosphorylation of IRS1 protein CTD PMID:28131861 ethanol multiple interactions EXP 6480464 [Ethanol results in decreased susceptibility to INS1 protein] which results in decreased expression of and results in decreased activity of IRS1 protein CTD PMID:12700235 flavonol multiple interactions ISO IRS1 (Homo sapiens) 6480464 3-hydroxyflavone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of IRS1 protein] CTD PMID:17458902 folic acid multiple interactions ISO Irs1 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of IRS1 gene CTD PMID:20938992 folic acid decreases expression ISO Irs1 (Mus musculus) 6480464 Folic Acid results in decreased expression of IRS1 mRNA CTD PMID:25629700 folpet increases expression ISO Irs1 (Mus musculus) 6480464 folpet results in increased expression of IRS1 mRNA CTD PMID:31558096 formaldehyde decreases expression ISO IRS1 (Homo sapiens) 6480464 Formaldehyde results in decreased expression of IRS1 mRNA CTD PMID:20655997 and PMID:27664576 FR900359 affects phosphorylation ISO IRS1 (Homo sapiens) 6480464 FR900359 affects the phosphorylation of IRS1 protein CTD PMID:37730182 fructose decreases phosphorylation EXP 6480464 Fructose results in decreased phosphorylation of IRS1 protein CTD PMID:22426011 fructose increases phosphorylation ISO Irs1 (Mus musculus) 6480464 Fructose results in increased phosphorylation of IRS1 protein CTD PMID:31672515 fructose affects phosphorylation EXP 6480464 Fructose affects the phosphorylation of IRS1 protein CTD PMID:26713546 fructose increases phosphorylation EXP 6480464 Fructose results in increased phosphorylation of IRS1 protein CTD PMID:24704288 fructose decreases expression EXP 6480464 Fructose results in decreased expression of IRS1 mRNA and Fructose results in decreased expression of IRS1 protein CTD PMID:19008412 and PMID:19165636 fructose multiple interactions EXP 6480464 [Fructose co-treated with Oleanolic Acid] results in increased expression of IRS1 mRNA more ... CTD PMID:19008412 more ... fulvestrant decreases expression ISO IRS1 (Homo sapiens) 6480464 fulvestrant results in decreased expression of IRS1 mRNA CTD PMID:15072547 fulvestrant multiple interactions ISO IRS1 (Homo sapiens) 6480464 Fulvestrant inhibits the reaction [[Hexachlorobenzene co-treated with Estradiol] results in increased phosphorylation of IRS1 protein] more ... CTD PMID:19879930 and PMID:31646340 gamma-hexachlorocyclohexane decreases phosphorylation EXP 6480464 Hexachlorocyclohexane results in decreased phosphorylation of IRS1 protein CTD PMID:30248393 Ganoderic acid A multiple interactions ISO Irs1 (Mus musculus) 6480464 [Dietary Fats co-treated with ganoderic acid A] affects the expression of IRS1 mRNA CTD PMID:29852127 genistein multiple interactions ISO IRS1 (Homo sapiens) 6480464 Genistein inhibits the reaction [bisphenol A results in increased phosphorylation of IRS1 protein] and Genistein inhibits the reaction [Estradiol results in increased phosphorylation of IRS1 protein] CTD PMID:23933164 genistein increases expression ISO IRS1 (Homo sapiens) 6480464 Genistein results in increased expression of IRS1 mRNA CTD PMID:22228119 gentamycin decreases expression EXP 6480464 Gentamicins results in decreased expression of IRS1 mRNA CTD PMID:33387578 Gingerenone A multiple interactions ISO Irs1 (Mus musculus) 6480464 gingerenone A promotes the reaction [PIK3R1 protein binds to IRS1 protein] CTD PMID:30296358 gingerol multiple interactions ISO Irs1 (Mus musculus) 6480464 gingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS1 mRNA] and gingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS1 protein] CTD PMID:22285432 ginsenoside Re multiple interactions ISO Irs1 (Mus musculus) 6480464 ginsenoside Re inhibits the reaction [TNF protein results in increased phosphorylation of IRS1 protein] CTD PMID:17885204 ginsenoside Re increases phosphorylation ISO Irs1 (Mus musculus) 6480464 ginsenoside Re results in increased phosphorylation of IRS1 protein CTD PMID:17885204 ginsenoside Re increases expression ISO Irs1 (Mus musculus) 6480464 ginsenoside Re results in increased expression of IRS1 mRNA CTD PMID:23545455 Ginsenoside Rh4 multiple interactions ISO Irs1 (Mus musculus) 6480464 ginsenoside Rh4 inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of IRS1 mRNA] CTD PMID:33359794 glucose multiple interactions ISO IRS1 (Homo sapiens) 6480464 ACACB protein affects the reaction [Glucose results in decreased phosphorylation of IRS1 protein] more ... CTD PMID:10430617 more ... glucose decreases phosphorylation ISO IRS1 (Homo sapiens) 6480464 Glucose results in decreased phosphorylation of IRS1 protein CTD PMID:33957017 glucose decreases expression ISO IRS1 (Homo sapiens) 6480464 Glucose results in decreased expression of IRS1 protein and Glucose results in decreased expression of IRS1 protein modified form CTD PMID:24262486 glucose increases phosphorylation ISO IRS1 (Homo sapiens) 6480464 Glucose results in increased phosphorylation of IRS1 protein CTD PMID:10430617 glyburide multiple interactions ISO IRS1 (Homo sapiens) 6480464 IRS1 protein polymorphism inhibits the reaction [Glyburide results in increased secretion of INS protein] CTD PMID:10430617 glyphosate decreases expression ISO IRS1 (Homo sapiens) 6480464 Glyphosate results in decreased expression of IRS1 mRNA CTD PMID:31295307 gypenoside LXXV decreases phosphorylation ISO Irs1 (Mus musculus) 6480464 gypenoside LXXV results in decreased phosphorylation of IRS1 protein CTD PMID:36325883 gypenoside LXXV multiple interactions ISO Irs1 (Mus musculus) 6480464 2-chloro-5-nitrobenzanilide inhibits the reaction [gypenoside LXXV results in decreased expression of and results in decreased phosphorylation of IRS1 protein] and gypenoside LXXV results in decreased expression of and results in decreased phosphorylation of IRS1 protein CTD PMID:35192202 hexachlorobenzene increases phosphorylation EXP 6480464 Hexachlorobenzene results in increased phosphorylation of IRS1 protein CTD PMID:16237195 hexachlorobenzene increases phosphorylation ISO IRS1 (Homo sapiens) 6480464 Hexachlorobenzene results in increased phosphorylation of IRS1 protein CTD PMID:19879930 hexachlorobenzene multiple interactions ISO IRS1 (Homo sapiens) 6480464 [Hexachlorobenzene co-treated with Estradiol] results in increased phosphorylation of IRS1 protein more ... CTD PMID:19879930 hexachlorobenzene increases expression EXP 6480464 Hexachlorobenzene results in increased expression of IRS1 protein CTD PMID:16237195 hexachlorobenzene multiple interactions EXP 6480464 Hexachlorobenzene inhibits the reaction [Methylnitrosourea results in increased phosphorylation of IRS1 protein] CTD PMID:16237195 hexadecanoic acid multiple interactions ISO IRS1 (Homo sapiens) 6480464 3 more ... CTD PMID:25815690 and PMID:30362509 hexadecanoic acid multiple interactions EXP 6480464 4-hydroxyisoleucine inhibits the reaction [Palmitic Acid inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]] and Palmitic Acid inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein] CTD PMID:25109277 hydroquinone decreases expression ISO IRS1 (Homo sapiens) 6480464 hydroquinone results in decreased expression of IRS1 mRNA CTD PMID:31256213 isoprenaline increases expression ISO Irs1 (Mus musculus) 6480464 Isoproterenol results in increased expression of IRS1 mRNA CTD PMID:20003209 ketanserin multiple interactions ISO Irs1 (Mus musculus) 6480464 [[Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]] which results in increased ubiquitination of and results in increased degradation of IRS1 protein and [Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]] CTD PMID:22975078 ketoconazole decreases expression EXP 6480464 Ketoconazole results in decreased expression of IRS1 mRNA CTD PMID:37077353 L-ascorbic acid multiple interactions EXP 6480464 [Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of IRS1 protein] and [Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Diethylhexyl Phthalate results in decreased phosphorylation of IRS1 protein] CTD PMID:21911000 L-methionine multiple interactions ISO Irs1 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of IRS1 gene CTD PMID:20938992 lead diacetate decreases expression EXP 6480464 lead acetate results in decreased expression of IRS1 mRNA CTD PMID:30980912 leflunomide decreases expression ISO Irs1 (Mus musculus) 6480464 leflunomide results in decreased expression of IRS1 mRNA CTD PMID:19751817 leflunomide increases expression ISO IRS1 (Homo sapiens) 6480464 leflunomide results in increased expression of IRS1 mRNA CTD PMID:28988120 linsidomine multiple interactions ISO Irs1 (Mus musculus) 6480464 linsidomine inhibits the reaction [INS1 protein results in increased phosphorylation of IRS1 protein] and linsidomine results in increased metabolism of and results in decreased expression of IRS1 protein CTD PMID:19682478 lipopolysaccharide multiple interactions ISO Irs1 (Mus musculus) 6480464 17-ethynyl-5-androstene-3 more ... CTD PMID:22384159 lipopolysaccharide multiple interactions ISO IRS1 (Homo sapiens) 6480464 [S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of IRS1 mRNA CTD PMID:35811015 lovastatin multiple interactions ISO Irs1 (Mus musculus) 6480464 [Dietary Fats co-treated with Lovastatin] affects the expression of IRS1 mRNA CTD PMID:29852127 LY294002 decreases phosphorylation EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of IRS1 protein CTD PMID:34455488 LY294002 multiple interactions EXP 6480464 Phosphocreatine inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of IRS1 protein] CTD PMID:34455488 melatonin multiple interactions ISO Irs1 (Mus musculus) 6480464 Melatonin inhibits the reaction [sodium arsenite results in decreased expression of IRS1 protein] CTD PMID:29763682 mercury atom multiple interactions ISO Irs1 (Mus musculus) 6480464 [Cadmium co-treated with Mercury] results in increased phosphorylation of IRS1 protein CTD PMID:30629257 mercury dibromide increases expression ISO IRS1 (Homo sapiens) 6480464 mercuric bromide results in increased expression of IRS1 mRNA CTD PMID:26272509 mercury dibromide multiple interactions ISO IRS1 (Homo sapiens) 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS1 mRNA CTD PMID:27188386 mercury(0) multiple interactions ISO Irs1 (Mus musculus) 6480464 [Cadmium co-treated with Mercury] results in increased phosphorylation of IRS1 protein CTD PMID:30629257 metformin multiple interactions EXP 6480464 Metformin inhibits the reaction [Dehydroepiandrosterone results in decreased phosphorylation of IRS1 protein] CTD PMID:27634381 metformin multiple interactions ISO Irs1 (Mus musculus) 6480464 Metformin inhibits the reaction [Streptozocin results in decreased expression of IRS1 protein] and Metformin promotes the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of IRS1 protein] CTD PMID:23927877 and PMID:31743741 metformin multiple interactions ISO IRS1 (Homo sapiens) 6480464 Metformin affects the reaction [Testosterone results in decreased expression of IRS1] more ... CTD PMID:19328476 more ... methamphetamine decreases phosphorylation ISO IRS1 (Homo sapiens) 6480464 Methamphetamine results in decreased phosphorylation of IRS1 protein CTD PMID:31270305 methamphetamine multiple interactions ISO IRS1 (Homo sapiens) 6480464 Rosiglitazone inhibits the reaction [Methamphetamine results in decreased phosphorylation of IRS1 protein] CTD PMID:31270305 methamphetamine multiple interactions ISO Irs1 (Mus musculus) 6480464 rosiglitazone inhibits the reaction [Methamphetamine results in increased phosphorylation of IRS1 protein] CTD PMID:29981415 methamphetamine increases phosphorylation ISO Irs1 (Mus musculus) 6480464 Methamphetamine results in increased phosphorylation of IRS1 protein CTD PMID:29981415 methoxychlor increases methylation EXP 6480464 Methoxychlor results in increased methylation of IRS1 gene CTD PMID:23303685 methylglyoxal decreases phosphorylation EXP 6480464 Pyruvaldehyde results in decreased phosphorylation of IRS1 protein CTD PMID:23954466 and PMID:34455488 methylglyoxal multiple interactions EXP 6480464 Phosphocreatine inhibits the reaction [Pyruvaldehyde results in decreased phosphorylation of IRS1 protein] CTD PMID:34455488 methylmercury chloride increases expression ISO IRS1 (Homo sapiens) 6480464 methylmercuric chloride results in increased expression of IRS1 mRNA CTD PMID:23179753 more ... methylmercury chloride multiple interactions ISO Irs1 (Mus musculus) 6480464 [Cadmium Chloride co-treated with methylmercuric chloride] results in decreased expression of IRS1 mRNA and [Cadmium Chloride co-treated with methylmercuric chloride] results in increased phosphorylation of IRS1 protein CTD PMID:27814245 and PMID:30629257 methylmercury chloride multiple interactions ISO IRS1 (Homo sapiens) 6480464 [NOG protein co-treated with methylmercuric chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS1 mRNA CTD PMID:27188386 metyrapone multiple interactions EXP 6480464 [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in increased phosphorylation of IRS1 protein CTD PMID:37088303 microcystin-LR increases phosphorylation ISO IRS1 (Homo sapiens) 6480464 cyanoginosin LR results in increased phosphorylation of IRS1 protein CTD PMID:28984034 microcystin-LR increases phosphorylation ISO Irs1 (Mus musculus) 6480464 cyanoginosin LR results in increased phosphorylation of IRS1 protein CTD PMID:31714646 and PMID:32073747 microcystin-LR decreases expression ISO Irs1 (Mus musculus) 6480464 cyanoginosin LR results in decreased expression of IRS1 mRNA CTD PMID:29777831 microcystin-LR decreases phosphorylation ISO Irs1 (Mus musculus) 6480464 cyanoginosin LR results in decreased phosphorylation of IRS1 protein CTD PMID:29777831 microcystin-LR multiple interactions ISO IRS1 (Homo sapiens) 6480464 cyanoginosin LR promotes the reaction [INS protein results in increased phosphorylation of IRS1 protein] more ... CTD PMID:28984034 microcystin-LR multiple interactions ISO Irs1 (Mus musculus) 6480464 cyanoginosin LR results in decreased expression of and results in increased phosphorylation of IRS1 protein CTD PMID:28984034 miquelianin multiple interactions ISO IRS1 (Homo sapiens) 6480464 quercetin 3-O-glucuronide inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]] and quercetin 3-O-glucuronide inhibits the reaction [Palmitates results in increased phosphorylation of IRS1 protein] CTD PMID:23504962 mono(2-ethylhexyl) phthalate decreases expression ISO Irs1 (Mus musculus) 6480464 mono-(2-ethylhexyl)phthalate results in decreased expression of IRS1 mRNA and mono-(2-ethylhexyl)phthalate results in decreased expression of IRS1 protein CTD PMID:25543134 and PMID:31009676 mono(2-ethylhexyl) phthalate multiple interactions ISO Irs1 (Mus musculus) 6480464 [INS1 protein co-treated with mono-(2-ethylhexyl)phthalate] results in decreased expression of IRS1 protein and mono-(2-ethylhexyl)phthalate inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein] CTD PMID:31009676 mono(2-ethylhexyl) phthalate multiple interactions ISO IRS1 (Homo sapiens) 6480464 [mono-(2-ethylhexyl)phthalate results in decreased activity of INS protein] which results in decreased phosphorylation of IRS1 protein more ... CTD PMID:31228551 mono(2-ethylhexyl) phthalate decreases phosphorylation ISO IRS1 (Homo sapiens) 6480464 mono-(2-ethylhexyl)phthalate results in decreased phosphorylation of IRS1 protein CTD PMID:31228551 mono(2-ethylhexyl) phthalate multiple interactions EXP 6480464 [INS1 protein co-treated with mono-(2-ethylhexyl)phthalate] results in decreased expression of IRS1 protein CTD PMID:28526321 myricetin multiple interactions EXP 6480464 myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in decreased expression of IRS1 protein] CTD PMID:24923654 N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide multiple interactions ISO Irs1 (Mus musculus) 6480464 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IRS1 mRNA] CTD PMID:17407152 N-acetyl-L-cysteine multiple interactions ISO IRS1 (Homo sapiens) 6480464 Acetylcysteine inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of IRS1 protein] CTD PMID:17458902 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO Irs1 (Mus musculus) 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [INS1 protein results in decreased expression of IRS1 protein] and benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [triptolide results in decreased expression of IRS1 protein] CTD PMID:24219910 and PMID:32061799 N-methyl-4-phenylpyridinium decreases expression ISO IRS1 (Homo sapiens) 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of IRS1 protein CTD PMID:26364587 N-methyl-4-phenylpyridinium multiple interactions ISO IRS1 (Homo sapiens) 6480464 INS protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of IRS1 protein] CTD PMID:26364587 N-methyl-N-nitrosourea multiple interactions EXP 6480464 Hexachlorobenzene inhibits the reaction [Methylnitrosourea results in increased phosphorylation of IRS1 protein] CTD PMID:16237195 N-methyl-N-nitrosourea increases phosphorylation EXP 6480464 Methylnitrosourea results in increased phosphorylation of IRS1 protein CTD PMID:16237195 N-nitrosodiethylamine affects expression EXP 6480464 Diethylnitrosamine affects the expression of IRS1 mRNA CTD PMID:20387270 N-nitrosomorpholine increases expression EXP 6480464 N-nitrosomorpholine results in increased expression of IRS1 protein CTD PMID:21411721 and PMID:9466558 N-phosphocreatine multiple interactions EXP 6480464 Phosphocreatine inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of IRS1 protein] more ... CTD PMID:34455488 naringin multiple interactions ISO Irs1 (Mus musculus) 6480464 naringin inhibits the reaction [Dietary Fats results in decreased phosphorylation of IRS1 protein] CTD PMID:22198281 nickel atom decreases expression ISO IRS1 (Homo sapiens) 6480464 Nickel results in decreased expression of IRS1 mRNA CTD PMID:25583101 nicotine decreases expression EXP 6480464 Nicotine results in decreased expression of IRS1 mRNA CTD PMID:22265867 oleanolic acid multiple interactions EXP 6480464 [Fructose co-treated with Oleanolic Acid] results in increased expression of IRS1 mRNA more ... CTD PMID:24704288 orientin multiple interactions ISO Irs1 (Mus musculus) 6480464 orientin inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of IRS1 protein] CTD PMID:32044341 ozone multiple interactions EXP 6480464 [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in increased phosphorylation of IRS1 protein more ... CTD PMID:33217375 more ... ozone decreases expression EXP 6480464 Ozone results in decreased expression of IRS1 mRNA CTD PMID:33217375 paracetamol decreases expression ISO IRS1 (Homo sapiens) 6480464 Acetaminophen results in decreased expression of IRS1 mRNA CTD PMID:21420995 paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of IRS1 mRNA CTD PMID:33387578 paracetamol increases expression ISO IRS1 (Homo sapiens) 6480464 Acetaminophen results in increased expression of IRS1 mRNA CTD PMID:22230336 paraquat multiple interactions ISO Irs1 (Mus musculus) 6480464 Paraquat results in decreased expression of and results in increased phosphorylation of IRS1 protein CTD PMID:23898955 paraquat increases phosphorylation EXP 6480464 Paraquat results in increased phosphorylation of IRS1 protein CTD PMID:36394833 paroxetine multiple interactions EXP 6480464 Paroxetine affects the reaction [INS protein affects the phosphorylation of IRS1 protein] and pyrazolanthrone inhibits the reaction [Paroxetine affects the reaction [INS protein affects the phosphorylation of IRS1 protein]] CTD PMID:17728140 paroxetine decreases activity EXP 6480464 Paroxetine results in decreased activity of IRS1 protein CTD PMID:17728140 perfluorododecanoic acid decreases expression EXP 6480464 perfluorododecanoic acid results in decreased expression of IRS1 protein modified form CTD PMID:23353032 perfluorononanoic acid decreases expression EXP 6480464 perfluoro-n-nonanoic acid results in decreased expression of IRS1 protein modified form CTD PMID:22387981 perfluorooctane-1-sulfonic acid increases expression ISO Irs1 (Mus musculus) 6480464 perfluorooctane sulfonic acid results in increased expression of IRS1 mRNA CTD PMID:26548598 perfluorooctane-1-sulfonic acid multiple interactions ISO Irs1 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of IRS1 mRNA CTD PMID:36331819 permethrin multiple interactions ISO IRS1 (Homo sapiens) 6480464 [Permethrin co-treated with INS protein] results in increased phosphorylation of IRS1 protein CTD PMID:28866332 phenethyl caffeate decreases expression ISO Irs1 (Mus musculus) 6480464 caffeic acid phenethyl ester results in decreased expression of IRS1 mRNA CTD PMID:21467634 phenylmercury acetate increases expression ISO IRS1 (Homo sapiens) 6480464 Phenylmercuric Acetate results in increased expression of IRS1 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO IRS1 (Homo sapiens) 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS1 mRNA CTD PMID:27188386 phosgene affects expression ISO Irs1 (Mus musculus) 6480464 Phosgene affects the expression of IRS1 mRNA CTD PMID:16300373 picoxystrobin decreases expression ISO IRS1 (Homo sapiens) 6480464 picoxystrobin results in decreased expression of IRS1 mRNA CTD PMID:33512557 pirinixic acid increases expression ISO Irs1 (Mus musculus) 6480464 pirinixic acid results in increased expression of IRS1 mRNA CTD PMID:18301758 pirinixic acid decreases expression ISO Irs1 (Mus musculus) 6480464 pirinixic acid results in decreased expression of IRS1 mRNA CTD PMID:18445702 procyanidin B1 multiple interactions ISO IRS1 (Homo sapiens) 6480464 [p-coumaric acid co-treated with procyanidin B1] results in increased expression of and results in increased phosphorylation of IRS1 protein and procyanidin B1 results in increased expression of and results in increased phosphorylation of IRS1 protein CTD PMID:34342938 procyanidin B1 multiple interactions ISO Irs1 (Mus musculus) 6480464 [procyanidin B1 co-treated with p-coumaric acid] results in increased expression of and results in increased phosphorylation of IRS1 protein and procyanidin B1 results in increased expression of and results in increased phosphorylation of IRS1 protein CTD PMID:34342938 progesterone decreases phosphorylation ISO IRS1 (Homo sapiens) 6480464 Progesterone results in decreased phosphorylation of IRS1 protein CTD PMID:15949379 progesterone increases phosphorylation ISO Irs1 (Mus musculus) 6480464 Progesterone results in increased phosphorylation of IRS1 protein CTD PMID:15604210 propiconazole increases expression ISO Irs1 (Mus musculus) 6480464 propiconazole results in increased expression of IRS1 mRNA CTD PMID:21278054 propionic acid decreases phosphorylation ISO Irs1 (Mus musculus) 6480464 propionic acid results in decreased phosphorylation of IRS1 protein CTD PMID:21472246 quercetin multiple interactions ISO IRS1 (Homo sapiens) 6480464 Quercetin affects the reaction [[Fatty Acids co-treated with INS protein] affects the phosphorylation of IRS1 protein] more ... CTD PMID:23504962 and PMID:24648896 quercetin multiple interactions ISO Irs1 (Mus musculus) 6480464 Quercetin inhibits the reaction [IGF1 protein results in increased phosphorylation of IRS1 protein] CTD PMID:24353828 quercetin decreases expression ISO IRS1 (Homo sapiens) 6480464 Quercetin results in decreased expression of IRS1 mRNA and Quercetin results in decreased expression of IRS1 protein CTD PMID:12653748 and PMID:21632981 quercetin multiple interactions EXP 6480464 Quercetin inhibits the reaction [Dehydroepiandrosterone results in decreased phosphorylation of IRS1 protein] and Quercetin inhibits the reaction [Fructose results in decreased phosphorylation of IRS1 protein] CTD PMID:22426011 and PMID:27634381 rebaudioside A multiple interactions ISO Irs1 (Mus musculus) 6480464 rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS1 mRNA] CTD PMID:25554529 resveratrol increases phosphorylation ISO Irs1 (Mus musculus) 6480464 resveratrol results in increased phosphorylation of IRS1 protein CTD PMID:22309033 resveratrol increases expression EXP 6480464 resveratrol results in increased expression of IRS1 mRNA and resveratrol results in increased expression of IRS1 protein CTD PMID:26071184 and PMID:26488877 resveratrol affects phosphorylation ISO Irs1 (Mus musculus) 6480464 resveratrol affects the phosphorylation of IRS1 protein CTD PMID:20188786 resveratrol decreases phosphorylation ISO Irs1 (Mus musculus) 6480464 resveratrol results in decreased phosphorylation of IRS1 protein CTD PMID:22935344 resveratrol decreases expression ISO Irs1 (Mus musculus) 6480464 resveratrol results in decreased expression of IRS1 mRNA and resveratrol results in decreased expression of IRS1 protein CTD PMID:18555852 more ... resveratrol decreases expression ISO IRS1 (Homo sapiens) 6480464 resveratrol results in decreased expression of IRS1 protein CTD PMID:18089832 resveratrol multiple interactions EXP 6480464 [Fructose co-treated with resveratrol] results in increased expression of IRS1 mRNA more ... CTD PMID:16626303 more ... resveratrol multiple interactions ISO IRS1 (Homo sapiens) 6480464 Resveratrol inhibits the reaction [bisphenol A results in increased expression of IRS1 protein modified form] more ... CTD PMID:17550345 more ... rivastigmine multiple interactions EXP 6480464 Rivastigmine inhibits the reaction [Streptozocin results in decreased expression of IRS1 mRNA] CTD PMID:32805344 rutin multiple interactions EXP 6480464 Rutin inhibits the reaction [Fructose results in decreased phosphorylation of IRS1 protein] CTD PMID:22426011 rutin multiple interactions ISO IRS1 (Homo sapiens) 6480464 Rutin results in increased susceptibility to [Vitamin E results in decreased expression of IRS1 protein] and Vitamin E results in increased susceptibility to [Rutin results in decreased expression of IRS1 protein] CTD PMID:20015448 rutin decreases expression ISO IRS1 (Homo sapiens) 6480464 Rutin results in decreased expression of IRS1 protein CTD PMID:20015448 S-(1,2-dichlorovinyl)-L-cysteine multiple interactions ISO IRS1 (Homo sapiens) 6480464 [S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of IRS1 mRNA CTD PMID:35811015 S-(1,2-dichlorovinyl)-L-cysteine decreases expression ISO IRS1 (Homo sapiens) 6480464 S-(1 and 2-dichlorovinyl)cysteine results in decreased expression of IRS1 mRNA CTD PMID:35811015 sarpogrelate multiple interactions ISO Irs1 (Mus musculus) 6480464 [sarpogrelate results in increased activity of AKT1 protein] inhibits the reaction [Serotonin results in increased ubiquitination of and results in increased degradation of IRS1 protein] CTD PMID:22975078 SB 203580 multiple interactions ISO IRS1 (Homo sapiens) 6480464 SB 203580 inhibits the reaction [bisphenol A results in increased expression of IRS1 protein modified form] CTD PMID:29793316 SB 431542 multiple interactions ISO IRS1 (Homo sapiens) 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 serotonin multiple interactions ISO Irs1 (Mus musculus) 6480464 [[Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]] which results in increased ubiquitination of and results in increased degradation of IRS1 protein more ... CTD PMID:22975078 sertraline multiple interactions EXP 6480464 Sertraline affects the reaction [INS protein affects the phosphorylation of IRS1 protein] CTD PMID:17728140 sertraline decreases activity EXP 6480464 Sertraline results in decreased activity of IRS1 protein CTD PMID:17728140 silicon dioxide decreases expression ISO Irs1 (Mus musculus) 6480464 Silicon Dioxide results in decreased expression of IRS1 mRNA CTD PMID:23221170 simvastatin multiple interactions ISO Irs1 (Mus musculus) 6480464 Simvastatin inhibits the reaction [IGF1 protein results in increased phosphorylation of IRS1 protein] CTD PMID:27734117 sirolimus affects phosphorylation ISO IRS1 (Homo sapiens) 6480464 Sirolimus affects the phosphorylation of IRS1 protein CTD PMID:17908691 sirolimus decreases phosphorylation ISO IRS1 (Homo sapiens) 6480464 Sirolimus results in decreased phosphorylation of IRS1 protein CTD PMID:16227402 sirolimus decreases degradation ISO IRS1 (Homo sapiens) 6480464 Sirolimus results in decreased degradation of IRS1 protein CTD PMID:16227402 and PMID:17908691 sirolimus multiple interactions ISO IRS1 (Homo sapiens) 6480464 [Sirolimus results in decreased activity of RPS6KB1 protein] which results in increased activity of IRS1 protein more ... CTD PMID:16227402 more ... sodium arsenate multiple interactions ISO IRS1 (Homo sapiens) 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of IRS1 mRNA CTD PMID:32525701 sodium arsenite decreases expression ISO IRS1 (Homo sapiens) 6480464 sodium arsenite results in decreased expression of IRS1 mRNA and sodium arsenite results in decreased expression of IRS1 protein CTD PMID:24570342 and PMID:34118311 sodium arsenite multiple interactions ISO IRS1 (Homo sapiens) 6480464 [INS protein co-treated with sodium arsenite] results in decreased expression of and results in decreased phosphorylation of IRS1 protein more ... CTD PMID:29526746 and PMID:33743404 sodium arsenite affects expression ISO Irs1 (Mus musculus) 6480464 sodium arsenite affects the expression of IRS1 CTD PMID:25367288 sodium arsenite decreases expression ISO Irs1 (Mus musculus) 6480464 sodium arsenite results in decreased expression of IRS1 mRNA and sodium arsenite results in decreased expression of IRS1 protein CTD PMID:22285432 and PMID:29763682 sodium arsenite multiple interactions ISO Irs1 (Mus musculus) 6480464 [sodium arsenite results in increased abundance of arsenite] which results in decreased expression of IRS1 protein more ... CTD PMID:22285432 more ... sodium arsenite increases methylation ISO IRS1 (Homo sapiens) 6480464 sodium arsenite results in increased methylation of IRS1 gene CTD PMID:24570342 Sodium salicylate multiple interactions ISO IRS1 (Homo sapiens) 6480464 Sodium Salicylate inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]] and Sodium Salicylate inhibits the reaction [Palmitates results in increased phosphorylation of IRS1 protein] CTD PMID:23504962 steviol multiple interactions ISO Irs1 (Mus musculus) 6480464 steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS1 mRNA] CTD PMID:25554529 stevioside multiple interactions ISO Irs1 (Mus musculus) 6480464 stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS1 mRNA] CTD PMID:25554529 streptozocin multiple interactions EXP 6480464 [Streptozocin co-treated with Cadmium] results in decreased expression of IRS1 protein more ... CTD PMID:24923654 more ... streptozocin decreases phosphorylation EXP 6480464 Streptozocin results in decreased phosphorylation of IRS1 protein CTD PMID:34455488 streptozocin decreases expression EXP 6480464 Streptozocin results in decreased expression of IRS1 mRNA and Streptozocin results in decreased expression of IRS1 protein CTD PMID:26071184 and PMID:32805344 streptozocin decreases expression ISO Irs1 (Mus musculus) 6480464 Streptozocin results in decreased expression of IRS1 protein CTD PMID:23927877 streptozocin multiple interactions ISO Irs1 (Mus musculus) 6480464 [Dietary Fats co-treated with Streptozocin] results in decreased expression of IRS1 mRNA more ... CTD PMID:23927877 more ... sucrose multiple interactions ISO IRS1 (Homo sapiens) 6480464 Oligosaccharides inhibits the reaction [[Sucrose co-treated with Dietary Fats] affects the expression of IRS1 mRNA] and Oligosaccharides inhibits the reaction [[Sucrose co-treated with Dietary Fats] affects the expression of IRS1 protein] CTD PMID:31181236 sulpiride multiple interactions EXP 6480464 Sulpiride results in decreased expression of and results in increased phosphorylation of IRS1 protein CTD PMID:29551354 sulpiride decreases expression EXP 6480464 Sulpiride results in decreased expression of IRS1 mRNA CTD PMID:29551354 sunitinib increases expression ISO IRS1 (Homo sapiens) 6480464 Sunitinib results in increased expression of IRS1 mRNA CTD PMID:31533062 tamoxifen affects expression ISO IRS1 (Homo sapiens) 6480464 Tamoxifen affects the expression of IRS1 mRNA CTD PMID:14699072 taurine increases phosphorylation EXP 6480464 Taurine results in increased phosphorylation of IRS1 protein CTD PMID:22138235 taurine multiple interactions ISO IRS1 (Homo sapiens) 6480464 Taurine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of IRS1 protein] CTD PMID:30362509 taurine multiple interactions EXP 6480464 Taurine inhibits the reaction [Alloxan results in decreased phosphorylation of IRS1 protein] CTD PMID:22138235 temozolomide increases expression ISO IRS1 (Homo sapiens) 6480464 Temozolomide results in increased expression of IRS1 mRNA CTD PMID:31758290 Tesaglitazar decreases expression EXP 6480464 tesaglitazar results in decreased expression of IRS1 mRNA CTD PMID:21515302 testosterone multiple interactions ISO IRS1 (Homo sapiens) 6480464 Metformin affects the reaction [Testosterone results in decreased expression of IRS1] CTD PMID:19328476 testosterone multiple interactions EXP 6480464 Testosterone inhibits the reaction [Dexamethasone results in decreased expression of IRS1 mRNA] CTD PMID:20032058 testosterone decreases expression ISO IRS1 (Homo sapiens) 6480464 Testosterone results in decreased expression of IRS1 CTD PMID:19328476 tetrachloromethane affects expression ISO Irs1 (Mus musculus) 6480464 Carbon Tetrachloride affects the expression of IRS1 mRNA CTD PMID:17484886 tetrachloromethane decreases expression ISO Irs1 (Mus musculus) 6480464 Carbon Tetrachloride results in decreased expression of IRS1 mRNA CTD PMID:31919559 thapsigargin multiple interactions ISO IRS1 (Homo sapiens) 6480464 Thapsigargin affects the phosphorylation of and results in decreased expression of IRS1 protein CTD PMID:22378314 theophylline increases expression ISO IRS1 (Homo sapiens) 6480464 Theophylline results in increased expression of IRS1 mRNA CTD PMID:16083514 thymoquinone multiple interactions EXP 6480464 thymoquinone inhibits the reaction [bisphenol A results in decreased phosphorylation of IRS1 protein] CTD PMID:33315269 Tiron multiple interactions ISO IRS1 (Homo sapiens) 6480464 1 more ... CTD PMID:17458902 titanium dioxide decreases expression ISO Irs1 (Mus musculus) 6480464 titanium dioxide results in decreased expression of IRS1 mRNA CTD PMID:23557971 and PMID:27760801 titanium dioxide multiple interactions ISO Irs1 (Mus musculus) 6480464 4-phenylbutyric acid inhibits the reaction [titanium dioxide results in increased phosphorylation of IRS1 protein] and [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of IRS1 mRNA CTD PMID:29950665 and PMID:31298478 titanium dioxide increases phosphorylation ISO Irs1 (Mus musculus) 6480464 titanium dioxide results in increased phosphorylation of IRS1 protein CTD PMID:31298478 and PMID:31769605 tributylstannane multiple interactions ISO Irs1 (Mus musculus) 6480464 tributyltin results in decreased expression of and results in decreased phosphorylation of IRS1 protein CTD PMID:28397090 tributylstannane increases expression ISO Irs1 (Mus musculus) 6480464 tributyltin results in increased expression of IRS1 mRNA CTD PMID:30027469 trichloroethene decreases expression ISO Irs1 (Mus musculus) 6480464 Trichloroethylene results in decreased expression of IRS1 mRNA CTD PMID:28973375 trichloroethene increases expression EXP 6480464 Trichloroethylene results in increased expression of IRS1 mRNA CTD PMID:33387578 trichostatin A increases expression ISO IRS1 (Homo sapiens) 6480464 trichostatin A results in increased expression of IRS1 mRNA CTD PMID:24935251 and PMID:26272509 trichostatin A multiple interactions ISO IRS1 (Homo sapiens) 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS1 mRNA CTD PMID:27188386 trimellitic anhydride decreases expression ISO Irs1 (Mus musculus) 6480464 trimellitic anhydride results in decreased expression of IRS1 mRNA CTD PMID:19042947 triphenyl phosphate increases expression ISO Irs1 (Mus musculus) 6480464 triphenyl phosphate results in increased expression of IRS1 mRNA CTD PMID:29316351 Triptolide increases degradation ISO Irs1 (Mus musculus) 6480464 triptolide results in increased degradation of IRS1 protein CTD PMID:32061799 Triptolide multiple interactions ISO Irs1 (Mus musculus) 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [triptolide results in decreased expression of IRS1 protein] and triptolide results in decreased expression of and results in decreased phosphorylation of IRS1 protein CTD PMID:32061799 tris(picolinato)chromium multiple interactions EXP 6480464 chromium tripicolinate promotes the reaction [INS1 protein results in increased phosphorylation of IRS1 protein] CTD PMID:16424121 troglitazone decreases expression EXP 6480464 troglitazone results in decreased expression of IRS1 mRNA CTD PMID:21515302 tunicamycin multiple interactions ISO IRS1 (Homo sapiens) 6480464 Tunicamycin affects the phosphorylation of and results in decreased expression of IRS1 protein CTD PMID:22378314 urethane decreases expression ISO IRS1 (Homo sapiens) 6480464 Urethane results in decreased expression of IRS1 mRNA CTD PMID:28818685 Ursonic acid multiple interactions ISO Irs1 (Mus musculus) 6480464 ursonic acid promotes the reaction [INS1 protein results in decreased phosphorylation of IRS1 protein] CTD PMID:36933777 valproic acid multiple interactions ISO IRS1 (Homo sapiens) 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS1 mRNA CTD PMID:27188386 valproic acid increases expression ISO IRS1 (Homo sapiens) 6480464 Valproic Acid results in increased expression of IRS1 mRNA CTD PMID:23179753 more ... vancomycin increases expression ISO Irs1 (Mus musculus) 6480464 Vancomycin results in increased expression of IRS1 mRNA CTD PMID:18930951 vanillic acid multiple interactions ISO IRS1 (Homo sapiens) 6480464 Vanillic Acid inhibits the reaction [INS protein results in increased expression of IRS1 protein] CTD PMID:36764371 vitamin E multiple interactions ISO IRS1 (Homo sapiens) 6480464 Rutin results in increased susceptibility to [Vitamin E results in decreased expression of IRS1 protein] and Vitamin E results in increased susceptibility to [Rutin results in decreased expression of IRS1 protein] CTD PMID:20015448 vitamin E decreases expression ISO IRS1 (Homo sapiens) 6480464 Vitamin E results in decreased expression of IRS1 protein CTD PMID:20015448 vitamin E multiple interactions EXP 6480464 [Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of IRS1 protein] and [Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Diethylhexyl Phthalate results in decreased phosphorylation of IRS1 protein] CTD PMID:21911000 wortmannin multiple interactions ISO IRS1 (Homo sapiens) 6480464 wortmannin inhibits the reaction [INS protein results in increased expression of IRS1 protein modified form] CTD PMID:20936651 wortmannin multiple interactions EXP 6480464 Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in decreased expression of IRS1 mRNA]] CTD PMID:32805344 zinc atom decreases expression ISO IRS1 (Homo sapiens) 6480464 Zinc results in decreased expression of IRS1 protein CTD PMID:19913001 zinc atom increases phosphorylation EXP 6480464 Zinc results in increased phosphorylation of IRS1 protein CTD PMID:14644152 zinc atom increases phosphorylation ISO Irs1 (Mus musculus) 6480464 Zinc results in increased phosphorylation of IRS1 protein CTD PMID:15516700 zinc(0) decreases expression ISO IRS1 (Homo sapiens) 6480464 Zinc results in decreased expression of IRS1 protein CTD PMID:19913001 zinc(0) increases phosphorylation ISO Irs1 (Mus musculus) 6480464 Zinc results in increased phosphorylation of IRS1 protein CTD PMID:15516700 zinc(0) increases phosphorylation EXP 6480464 Zinc results in increased phosphorylation of IRS1 protein CTD PMID:14644152