Egfr (epidermal growth factor receptor) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Egfr (epidermal growth factor receptor) Rattus norvegicus
Analyze
Symbol: Egfr
Name: epidermal growth factor receptor
RGD ID: 2543
Description: Enables several functions, including calmodulin binding activity; epidermal growth factor binding activity; and epidermal growth factor-activated receptor activity. Involved in several processes, including animal organ development; neurogenesis; and positive regulation of cell communication. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and cytoplasmic vesicle. Used to study bronchiolo-alveolar adenocarcinoma; dilated cardiomyopathy; and high grade glioma. Biomarker of several diseases, including Parkinsonism; acute kidney failure; lung disease (multiple); median neuropathy; and peptic esophagitis. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; lung non-small cell carcinoma (multiple); pancreatic cancer; prostate cancer; and pulmonary tuberculosis. Orthologous to human EGFR (epidermal growth factor receptor); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; altered epidermal growth factor/neuregulin signaling pathway; cetuximab pharmacodynamics pathway; INTERACTS WITH (+)-pilocarpine; (R)-mevalonic acid; (R)-noradrenaline.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: avian erythroblastic leukemia viral (v-erbB) oncogene homolog; Egfr-related peptide; Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); Epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); ErbB-1; ERBB1; Errp
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21491,176,931 - 91,349,722 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1491,177,067 - 91,344,382 (+)Ensembl
Rnor_6.01499,919,485 - 100,104,136 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1499,919,485 - 100,098,796 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014100,438,989 - 100,617,315 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41497,617,358 - 97,788,211 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1490,225,928 - 90,392,779 (+)NCBICelera
RH 3.4 Map14 RGD
Cytogenetic Map14q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IEP,ISO)
Acute Lung Injury  (ISO)
adenocarcinoma  (ISO)
adrenocortical carcinoma  (ISO)
Alcoholic Liver Diseases  (ISO)
Alzheimer's disease  (ISO)
Animal Mammary Neoplasms  (ISO)
aortic valve disease  (ISS)
aortic valve stenosis  (ISO)
arteriovenous malformations of the brain  (ISO)
asthma  (IEP,ISO)
autistic disorder  (ISO)
autosomal recessive polycystic kidney disease  (ISO)
Bannayan-Riley-Ruvalcaba syndrome  (ISO)
Bile Duct Neoplasms  (ISO)
Brain Neoplasms  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
bronchiolo-alveolar adenocarcinoma  (IMP,ISO)
carcinoma  (ISO)
Cardiomegaly  (ISO)
Chloracne  (ISO)
cholangiocarcinoma  (ISO)
chronic obstructive pulmonary disease  (IEP,ISO)
Colonic Neoplasms  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
Coronavirus infectious disease  (ISS)
Craniofacial Abnormalities  (ISO)
dementia  (ISO)
dermatitis  (ISO)
diabetic retinopathy  (ISO)
dilated cardiomyopathy  (IMP,ISO)
Disease Progression  (ISO)
endometrial carcinoma  (ISO)
Endometrioid Carcinomas  (ISO)
endometriosis  (ISO)
esophageal carcinoma  (ISO)
Esophageal Neoplasms  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (IDA)
familial adenomatous polyposis  (ISO)
Gallbladder Neoplasms  (ISO)
glioblastoma  (ISO)
Head and Neck Neoplasms  (ISO)
head and neck squamous cell carcinoma  (ISO)
Helicobacter Infections  (ISO)
hepatocellular carcinoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
high grade glioma  (IMP,ISO)
Huntington's disease  (ISO)
Hyperplasia  (IEP)
hypertension  (IEP)
Immediate Hypersensitivity  (ISO)
Inflammation  (IMP)
Insulin Resistance  (ISO)
Laryngeal Neoplasms  (ISO)
laryngeal squamous cell carcinoma  (ISO)
Left Ventricular Hypertrophy  (IDA)
leiomyoma  (ISO)
liver cirrhosis  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO,ISS)
lung carcinoma  (ISO)
lung disease  (IEP)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
malignant mesothelioma  (ISO)
Mammary Neoplasms, Experimental  (ISO)
median neuropathy  (IEP)
Mesothelioma  (ISO)
Nasopharyngeal Neoplasms  (ISO)
Neonatal Inflammatory Skin and Bowel Disease 2  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplasm Recurrence, Local  (ISO)
obesity  (ISO)
oral squamous cell carcinoma  (ISO)
osteosarcoma  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
papilloma  (ISO)
papillomavirus infectious disease  (ISO)
Parkinson's disease  (ISO)
Parkinsonism  (IEP)
peptic esophagitis  (IEP)
Phyllodes Tumor  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary fibrosis  (IEP,ISO)
pulmonary hypertension  (ISO)
Pulmonary Hypertension, Hypoxia-Induced  (IMP)
pulmonary tuberculosis  (ISO)
rectal benign neoplasm  (ISO)
renal cell carcinoma  (ISO)
Right Ventricular Hypertrophy  (IMP)
schizophrenia  (ISO)
severe acute respiratory syndrome  (ISO)
Spinal Cord Injuries  (IEP,IMP)
squamous cell carcinoma  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
Tobacco Use Disorder  (IEP)
tongue squamous cell carcinoma  (ISO)
transitional cell carcinoma  (ISO)
type 1 diabetes mellitus  (IEP)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
Vascular Remodeling  (IMP)
Ventricular Fibrillation  (IMP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-Tetrandrine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(20R)-protopanaxadiol  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(R)-mevalonic acid  (EXP)
(R)-noradrenaline  (EXP)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP,ISO)
1,2,3,4,7,8-Hexachlorodibenzofuran  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,2-naphthoquinone  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
16,16-dimethylprostaglandin E2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 17-glucosiduronic acid  (EXP)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,5-hexanedione  (EXP)
2-acetamidofluorene  (EXP)
2-deoxy-D-glucose  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxy-17beta-estradiol  (ISO)
2-nitrotoluene  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4'-epidoxorubicin  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrotoluene  (ISO)
4-tert-Octylphenol  (EXP)
4-vinylcyclohexene dioxide  (ISO)
5,6alpha-epoxy-5alpha-cholestan-3beta-ol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-chrysenamine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
7-ketocholesterol  (EXP)
8-Br-cAMP  (ISO)
9,10-phenanthroquinone  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (EXP,ISO)
acrylamide  (ISO)
acteoside  (ISO)
actinomycin D  (EXP)
afatinib  (ISO)
afimoxifene  (ISO)
AH23848  (ISO)
AICA ribonucleotide  (ISO)
aldosterone  (EXP)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
alpha-naphthoflavone  (ISO)
alpha-pinene  (ISO)
alprenolol  (ISO)
aluminium oxide  (ISO)
AM-251  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amosite asbestos  (EXP,ISO)
amphibole asbestos  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimonite  (ISO)
antirheumatic drug  (ISO)
ANTU  (EXP)
apocynin  (ISO)
arachidonic acid  (EXP)
arecoline  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic acid  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
astragaloside IV  (EXP)
atenolol  (ISO)
atorvastatin calcium  (ISO)
ATP  (ISO)
atrazine  (ISO)
atropine  (ISO)
avobenzone  (ISO)
bafilomycin A1  (ISO)
baicalein  (ISO)
baicalin  (ISO)
benzamide  (ISO)
benzamidine  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzoic acid  (ISO)
betulin  (ISO)
betulinic acid  (ISO)
bicalutamide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bosutinib  (ISO)
butan-1-ol  (EXP)
butane-2,3-dione  (ISO)
butylated hydroxyanisole  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (EXP,ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
canertinib  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP,ISO)
carbon nanotube  (ISO)
carvacrol  (ISO)
carvedilol  (ISO)
casticin  (ISO)
celastrol  (ISO)
celecoxib  (EXP)
chloroprene  (EXP)
chloroquine  (EXP,ISO)
chlorothalonil  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysin  (ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (ISO)
cimetidine  (ISO)
ciprofibrate  (EXP)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crizotinib  (ISO)
crocidolite asbestos  (EXP,ISO)
Cryptotanshinone  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cyanocob(III)alamin  (ISO)
cycloheximide  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP,ISO)
cytochalasin B  (ISO)
cytochalasin D  (ISO)
dacomitinib  (ISO)
daidzein  (ISO)
DDE  (EXP)
Deguelin  (ISO)
dehydroepiandrosterone  (ISO)
delphinidin  (ISO)
deoxycholic acid  (EXP,ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibenziodolium  (EXP,ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (EXP)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
disodium selenite  (ISO)
dobutamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
epoxiconazole  (EXP)
equol  (ISO)
Erionite  (EXP)
erlotinib hydrochloride  (ISO)
estrone  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
eugenol  (ISO)
everolimus  (ISO)
Evodiamine  (ISO)
fenamidone  (ISO)
fenofibrate  (ISO)
ferric oxide  (ISO)
fisetin  (ISO)
fluoranthene  (ISO)
fluoxetine  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
galangin  (ISO)
gallic acid  (ISO)
gedunin  (ISO)
gefitinib  (EXP,ISO)
geldanamycin  (EXP,ISO)
gemcitabine  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
glafenine  (EXP)
glutathione  (ISO)
glycine betaine  (ISO)
glyphosate  (ISO)
Goe 6976  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
heparin  (ISO)
herbicide  (EXP)
hexachlorobenzene  (EXP,ISO)
hexadecanoic acid  (ISO)
histamine  (ISO)
hyaluronic acid  (ISO)
hydrogen chloride  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroxamic acid  (ISO)
hyperforin  (ISO)
hypochlorous acid  (ISO)
icariin  (EXP)
icariside II  (ISO)
ICI-164384  (ISO)
indole-3-methanol  (ISO)
indometacin  (EXP,ISO)
irbesartan  (EXP)
irinotecan  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoflavones  (EXP)
isoprenaline  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
KN-93  (EXP,ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lansoprazole  (ISO)
lapatinib  (ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (ISO)
lead(0)  (EXP)
lead(2+)  (EXP)
leflunomide  (ISO)
leukotriene C4  (ISO)
linalool  (ISO)
linuron  (EXP)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
lovastatin  (ISO)
luteolin  (ISO)
LY294002  (ISO)
magnesium dichloride  (ISO)
Malabaricone C  (ISO)
manganese(II) chloride  (EXP,ISO)
melittin  (ISO)
menadione  (EXP)
mercury dichloride  (EXP)
metamizole sodium  (EXP)
methapyrilene  (EXP)
methotrexate  (EXP,ISO)
methoxychlor  (EXP,ISO)
Methylazoxymethanol acetate  (EXP)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
mifepristone  (EXP,ISO)
MK-2206  (ISO)
monosodium L-glutamate  (EXP,ISO)
myo-inositol hexakisphosphate  (ISO)
myricetin  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylcysteamine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-methylformamide  (ISO)
N-methylnicotinate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naphthalene  (ISO)
naringin  (ISO)
nefazodone  (EXP)
neocuproine  (ISO)
neratinib  (ISO)
nevirapine  (ISO)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (EXP)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nobiletin  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
oleic acid  (ISO)
oridonin  (ISO)
osimertinib  (ISO)
ouabain  (ISO)
oxaliplatin  (EXP,ISO)
oxazepam  (ISO)
oxytocin  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
p-tert-Amylphenol  (EXP)
paclitaxel  (ISO)
Paeonol  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
parathion  (ISO)
paroxetine  (ISO)
PD 168393  (EXP,ISO)
pentane-2,3-dione  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
PHA-665752  (ISO)
phenobarbital  (EXP,ISO)
phenylarsine oxide  (ISO)
phenylephrine  (EXP,ISO)
phenylmercury acetate  (ISO)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phorone  (ISO)
phosphoramidon  (ISO)
piperonyl butoxide  (ISO)
pirfenidone  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (EXP,ISO)
platycodin D  (ISO)
ponatinib  (ISO)
potassium chromate  (ISO)
primaquine  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
progesterone  (EXP,ISO)
propofol  (ISO)
propranolol  (ISO)
prostaglandin E2  (ISO)
protein kinase inhibitor  (ISO)
protoporphyrin  (ISO)
Ptaquiloside  (ISO)
pterostilbene  (ISO)
purpurin  (ISO)
pyocyanine  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
quinazolines  (ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
raloxifene  (EXP,ISO)
ranitidine  (EXP)
reactive oxygen species  (EXP,ISO)
resveratrol  (ISO)
romidepsin  (ISO)
rotenone  (EXP)
rottlerin  (ISO)
rutin  (ISO)
SB 431542  (ISO)
scopolamine  (EXP)
selenium atom  (ISO)
selenomethionine  (ISO)
serpentine asbestos  (ISO)
sertraline  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium hydroxide  (ISO)
sorafenib  (ISO)
sphingosine 1-phosphate  (ISO)
staurosporine  (ISO)
stilbenoid  (ISO)
SU6656  (ISO)
succimer  (ISO)
sulfasalazine  (ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (EXP,ISO)
Sulpyrine  (EXP)
sunitinib  (ISO)
suramin  (EXP)
tamoxifen  (ISO)
tanespimycin  (ISO)
taurocholic acid  (ISO)
tephrosin  (ISO)
Terfenadine  (ISO)
teriflunomide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
tetramethylpyrazine  (ISO)
tetraphene  (ISO)
tetrathiomolybdate(2-)  (ISO)
thapsigargin  (ISO)
theaflavin  (ISO)
thioacetamide  (EXP)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP,ISO)
torin 1  (ISO)
trans-piceid  (ISO)
triamterene  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (ISO)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
trovafloxacin  (ISO)
tyrphostin AG 1478  (EXP,ISO)
U-73122  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
ursolic acid  (ISO)
UTP  (EXP)
valdecoxib  (EXP)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
vandetanib  (ISO)
veliparib  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (EXP,ISO)
WIN 55212-2  (ISO)
wortmannin  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc sulfate  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
astrocyte activation  (IMP)
cell differentiation  (IBA)
cell morphogenesis  (ISO)
cell surface receptor signaling pathway  (ISO)
cell-cell adhesion  (ISO)
cellular response to amino acid stimulus  (ISO)
cellular response to cadmium ion  (ISO)
cellular response to dexamethasone stimulus  (IEP)
cellular response to epidermal growth factor stimulus  (IDA)
cellular response to estradiol stimulus  (ISO)
cellular response to growth factor stimulus  (IEP,ISO)
cellular response to mechanical stimulus  (IEP)
cellular response to reactive oxygen species  (ISO)
cellular response to xenobiotic stimulus  (IEP)
cerebral cortex cell migration  (ISO)
circadian rhythm  (IEP)
digestive tract morphogenesis  (ISO)
diterpenoid metabolic process  (IEP)
embryonic placenta development  (ISO)
epidermal growth factor receptor signaling pathway  (IDA,IMP,ISO)
epidermis development  (ISO)
eyelid development in camera-type eye  (ISO)
hair follicle development  (IEP,ISO)
hydrogen peroxide metabolic process  (IEP)
intracellular signal transduction  (IDA)
learning or memory  (IDA)
liver development  (IEP)
liver regeneration  (IEP,IMP)
lung development  (IEP)
magnesium ion homeostasis  (IMP)
midgut development  (IEP)
morphogenesis of an epithelial fold  (ISO)
negative regulation of apoptotic process  (IBA,IMP,ISO)
negative regulation of cardiocyte differentiation  (ISO)
negative regulation of mitotic cell cycle  (IMP)
negative regulation of protein catabolic process  (ISO)
neuron projection morphogenesis  (IMP)
ovulation cycle  (IMP)
peptidyl-tyrosine autophosphorylation  (ISO)
peptidyl-tyrosine phosphorylation  (IDA,ISO)
positive regulation of bone resorption  (IMP)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of cell growth  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (IBA,ISO)
positive regulation of cyclin-dependent protein serine/threonine kinase activity  (ISO)
positive regulation of DNA repair  (ISO)
positive regulation of DNA replication  (ISO)
positive regulation of epithelial cell proliferation  (IBA,ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of G1/S transition of mitotic cell cycle  (ISO)
positive regulation of glial cell proliferation  (IMP)
positive regulation of inflammatory response  (IMP)
positive regulation of kinase activity  (IBA)
positive regulation of MAP kinase activity  (ISO)
positive regulation of MAPK cascade  (IMP)
positive regulation of mucus secretion  (IMP)
positive regulation of NIK/NF-kappaB signaling  (ISO)
positive regulation of nitric oxide mediated signal transduction  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of phosphorylation  (ISO)
positive regulation of production of miRNAs involved in gene silencing by miRNA  (ISO)
positive regulation of prolactin secretion  (IDA)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of protein kinase C activity  (ISO)
positive regulation of protein localization to plasma membrane  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of smooth muscle cell proliferation  (IMP)
positive regulation of superoxide anion generation  (IMP)
positive regulation of synaptic transmission, glutamatergic  (IMP)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of vasoconstriction  (IMP)
protein autophosphorylation  (IDA,ISO)
receptor-mediated endocytosis  (ISO)
regulation of cell population proliferation  (ISO)
regulation of ERK1 and ERK2 cascade  (ISO)
regulation of JNK cascade  (ISO)
regulation of nitric-oxide synthase activity  (ISO)
regulation of peptidyl-tyrosine phosphorylation  (ISO)
regulation of phosphatidylinositol 3-kinase signaling  (ISO)
response to calcium ion  (IMP)
response to cobalamin  (IEP)
response to estradiol  (IEP)
response to hydroxyisoflavone  (IEP)
response to lipid  (IEP)
response to organic cyclic compound  (IEP)
response to osmotic stress  (IEP)
response to oxidative stress  (IEP)
response to UV-A  (ISO)
salivary gland morphogenesis  (ISO)
signal transduction  (IDA,ISO)
tongue development  (IEP)
translation  (IDA)
transmembrane receptor protein tyrosine kinase signaling pathway  (IBA)
vasodilation  (IMP)
wound healing  (IMP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
1. Al-Sahaf O, etal., Ann Surg. 2010 Dec;252(6):1037-43.
2. Amsellem-Ouazana D, etal., J Urol. 2006 Mar;175(3 Pt 1):1127-32.
3. Audisio C, etal., Neuroreport. 2008 Oct 29;19(16):1605-9. doi: 10.1097/WNR.0b013e32831313ef.
4. Bailly M, etal., Mol Biol Cell. 2000 Nov;11(11):3873-83.
5. Bei R, etal., J Pathol. 2001 Oct;195(3):343-8. doi: 10.1002/path.965.
6. Blackshear PJ, etal., J Biol Chem. 1987 Sep 5;262(25):12356-64.
7. Bonner JA, etal., N Engl J Med. 2006 Feb 9;354(6):567-78.
8. Bussu F, etal., Laryngoscope. 2012 Aug;122(8):1724-33. doi: 10.1002/lary.23311. Epub 2012 May 1.
9. Carpe N, etal., Am J Respir Cell Mol Biol. 2010 Dec;43(6):720-30. Epub 2010 Jan 29.
10. Carroll SL, etal., J Neurosci 1997 Mar 1;17(5):1642-59.
11. Carver RS, etal., Gastroenterology. 2002 Dec;123(6):2017-27.
12. Chadwick W, etal., J Signal Transuct. 2011;2011. pii: 636951.
13. Chen B, etal., Nat Genet 2000 Mar;24(3):296-9.
14. Chen HY, etal., Oncotarget. 2016 Feb 23;7(8):9017-25. doi: 10.18632/oncotarget.7029.
15. Cunningham D, etal., N Engl J Med. 2004 Jul 22;351(4):337-45.
16. Dahl Steffensen K, etal., Int J Oncol. 2008 Jul;33(1):195-204.
17. de Boer WI, etal., Am J Clin Pathol. 2006 Feb;125(2):184-92.
18. DiCamillo SJ, etal., J Biol Chem 2002 May 24;277(21):18938-46. Epub 2002 Mar 11.
19. Diez JA, etal., Mol Cell Biochem. 1998 Oct;187(1-2):201-10.
20. Ejskjaer K, etal., Gynecol Oncol. 2007 Jan;104(1):158-67. Epub 2006 Sep 7.
21. Faundez V, etal., J Biol Chem. 1992 Oct 5;267(28):20363-70.
22. Feng M, etal., Cardiovasc Res. 2012 Jan 1;93(1):60-8. doi: 10.1093/cvr/cvr281. Epub 2011 Oct 25.
23. Ferrandina G, etal., Hum Reprod. 1995 Jul;10(7):1845-9.
24. Ferreira SC, etal., Int J Sports Med. 2010 Dec;31(12):906-12. Epub 2010 Nov 11.
25. Francois H, etal., FASEB J. 2004 May;18(7):926-8. Epub 2004 Mar 19.
26. Franklin WA, etal., Semin Oncol. 2002 Feb;29(1 Suppl 4):3-14.
27. Fuchs I, etal., Anticancer Res. 2007 Mar-Apr;27(2):959-63.
28. Fujiwara Y, etal., Aliment Pharmacol Ther. 2002 Apr;16 Suppl 2:52-8.
29. Futamura T, etal., Mol Psychiatry. 2002;7(7):673-82.
30. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
31. Gilbert JA, etal., Mol Cancer Ther. 2008 Apr;7(4):944-51.
32. Gilbert RE, etal., Kidney Int. 2011 Mar 9.
33. Giraudi PJ, etal., Liver Int. 2018 Jan;38(1):155-163. doi: 10.1111/liv.13505. Epub 2017 Jul 21.
34. GOA data from the GO Consortium
35. Gravis G, etal., Ann Oncol. 2008 May 7;.
36. Green MR and Couchman JR, J Invest Dermatol. 1984 Aug;83(2):118-23.
37. Gui Y and Zheng XL, J Biol Chem. 2003 Dec 26;278(52):53017-25. Epub 2003 Oct 9.
38. Guo YS, etal., J Biol Chem 2002 Dec 13;277(50):48755-63.
39. Hamilton LM, etal., Clin Exp Allergy. 2003 Feb;33(2):233-40.
40. Han Q, etal., Biomaterials. 2010 Dec;31(35):9212-20.
41. Hapgood J, etal., Proc Natl Acad Sci U S A. 1983 Nov;80(21):6451-5.
42. Harada C, etal., Am J Respir Crit Care Med. 2011 Mar 15;183(6):743-51. Epub 2010 Oct 8.
43. Hardie WD, etal., Am J Respir Cell Mol Biol. 1996 Oct;15(4):499-508.
44. Heigener DF, etal., Lung Cancer. 2011 Mar 23.
45. Hise MK, etal., Nephron. 2001 May;88(1):71-9.
46. Hong HH, etal., Toxicol Pathol. 2015 Aug;43(6):872-82. doi: 10.1177/0192623315581192. Epub 2015 Jun 9.
47. Hou J, etal., Endocrinology 2002 Feb;143(2):577-86.
48. Howes AL, etal., J Mol Cell Cardiol. 2006 May;40(5):597-604. Epub 2006 Feb 8.
49. Hua H, etal., Am J Physiol Renal Physiol 2003 Feb;284(2):F303-12.
50. Hwang IK, etal., Cancer Res Treat. 2019 Jan;51(1):158-168. doi: 10.4143/crt.2018.084. Epub 2018 Apr 2.
51. Ibbotson KJ, etal., Endocrinology. 1985 Jan;116(1):469-71.
52. Inada S, etal., Surg Today. 1999;29(6):493-503.
53. Ito Y, etal., Br J Cancer. 2001 May 18;84(10):1377-83. doi: 10.1054/bjoc.2000.1580.
54. Iwakura Y, etal., J Neurochem. 2005 May;93(4):974-83.
55. Jang EJ, etal., Naunyn Schmiedebergs Arch Pharmacol. 2012 Dec 12.
56. Johansson S, etal., Hepatology. 1990 Sep;12(3 Pt 1):533-41.
57. Jurkowska G, etal., Adv Med Sci. 2014 Sep;59(2):221-6. doi: 10.1016/j.advms.2014.01.006. Epub 2014 Jun 9.
58. Kagiyama S, etal., Hypertension. 2003 Mar;41(3 Pt 2):824-9. Epub 2002 Dec 2.
59. Kalemi TG, etal., Anticancer Res. 2007 Mar-Apr;27(2):913-20.
60. Kang HN, etal., Lung Cancer. 2016 May;95:57-64. doi: 10.1016/j.lungcan.2016.02.013. Epub 2016 Feb 27.
61. Karkoulias G, etal., Cell Signal. 2006 May;18(5):729-39. Epub 2005 Aug 10.
62. Kassouf W, etal., J Urol. 2008 Jan;179(1):353-8. Epub 2007 Nov 19.
63. Kempiak SJ, etal., J Cell Biol. 2003 Sep 1;162(5):781-7.
64. Kim S, etal., Am J Physiol Lung Cell Mol Physiol 2002 Jul;283(1):L67-75.
65. Kim Y, etal., Mol Immunol. 2011 Apr;48(8):1035-45. Epub 2011 Feb 23.
66. Kontić M, etal., Acta Otolaryngol. 2019 Oct;139(10):913-917. doi: 10.1080/00016489.2019.1651938. Epub 2019 Aug 20.
67. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
68. Lai WW, etal., Ann Thorac Surg. 2001 Dec;72(6):1868-76. doi: 10.1016/s0003-4975(01)03207-6.
69. Lazarovici P, etal., J Cell Biol. 1987 Jun;104(6):1611-21.
70. Le Cras TD, etal., Am J Physiol Lung Cell Mol Physiol. 2003 Nov;285(5):L1046-54. Epub 2003 Aug 1.
71. Le Cras TD, etal., Am J Physiol Lung Cell Mol Physiol. 2011 Mar;300(3):L414-21. Epub 2010 Dec 17.
72. Lee J, etal., J Natl Cancer Inst. 2011 Apr 20;103(8):674-88. Epub 2011 Mar 11.
73. Lev-Ran A, etal., Cancer Res. 1986 Sep;46(9):4656-9.
74. Li L, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2010 Dec;30(12):2675-8.
75. Li SH, etal., J Neurosci. 2003 Jul 30;23(17):6956-64.
76. Li ZW, etal., Neurochem Int. 2011 Mar 21.
77. Liao Y, etal., Biochem Biophys Res Commun. 2005 Feb 25;327(4):1083-7.
78. Liu B, etal., J Neurosci. 2006 Jul 12;26(28):7532-40.
79. Liu G, etal., Hypertens Res. 2010 Dec;33(12):1250-7. Epub 2010 Oct 7.
80. Liu W, etal., Biochim Biophys Acta. 2007 Jul;1772(7):737-47. Epub 2007 May 5.
81. Liu X, etal., PLoS One. 2011 Jan 31;6(1):e16712. doi: 10.1371/journal.pone.0016712.
82. Long HC, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2009 Jul;32(7):517-21.
83. Luo Y, etal., Eur J Pharmacol. 2011 Mar 5;654(2):173-80. Epub 2010 Dec 21.
84. Luo YH, etal., J Thorac Oncol. 2012 Feb;7(2):299-305. doi: 10.1097/JTO.0b013e31823c588d.
85. Lynch TJ, etal., N Engl J Med. 2004 May 20;350(21):2129-39. Epub 2004 Apr 29.
86. Madtes DK, etal., Am J Respir Cell Mol Biol. 1994 Nov;11(5):540-51.
87. Madtes DK, etal., Am J Respir Crit Care Med. 1998 Aug;158(2):424-30.
88. Magkou C, etal., Breast Cancer Res. 2008 Jun 3;10(3):R49.
89. Masuelli L, etal., Int J Oncol. 2007 Feb;30(2):381-92.
90. Maurizi M, etal., Br J Cancer. 1996 Oct;74(8):1253-7.
91. McLaughlin SK J Neurosci. 2000 Aug 1;20(15):5679-88.
92. Meena AS, etal., J Nutr Biochem. 2019 Feb;64:128-143. doi: 10.1016/j.jnutbio.2018.10.016. Epub 2018 Nov 6.
93. Memon AA, etal., Br J Cancer. 2006 Jun 5;94(11):1703-9.
94. Messing EM, etal., J Urol. 1987 Nov;138(5):1329-35.
95. MGD data from the GO Consortium
96. Miyazaki Y, etal., Gastroenterology. 2001 Jan;120(1):108-16.
97. Moore MJ, etal., J Clin Oncol. 2007 May 20;25(15):1960-6. Epub 2007 Apr 23.
98. Mukku VR and Stancel GM, J Biol Chem. 1985 Aug 15;260(17):9820-4.
99. Mutti E, etal., Brain Res. 2011 Feb 28;1376:23-30. Epub 2010 Dec 23.
100. Nanjundan M, etal., J Thorac Oncol. 2010 Dec;5(12):1894-904.
101. NCBI rat LocusLink and RefSeq merged data July 26, 2002
102. Nie YC, etal., Pulm Pharmacol Ther. 2012 Oct;25(5):349-56. doi: 10.1016/j.pupt.2012.06.004. Epub 2012 Jun 23.
103. Norton CE, etal., Am J Respir Cell Mol Biol. 2020 Jan;62(1):61-73. doi: 10.1165/rcmb.2018-0106OC.
104. Norton CE, etal., Antioxid Redox Signal. 2012 Oct 18.
105. Okamoto M, etal., Am J Physiol. 1988 Apr;254(4 Pt 1):E429-34.
106. OMIM Disease Annotation Pipeline
107. Otova B, etal., Invest New Drugs. 2011 Mar 30.
108. Overbeek MJ, etal., Arthritis Res Ther. 2011 Apr 14;13(2):R61.
109. Pai R, etal., Nat Med 2002 Mar;8(3):289-93.
110. Pao W, etal., PLoS Med. 2005 Mar;2(3):e73. Epub 2005 Feb 22.
111. Paranjpe S, etal., Am J Pathol. 2010 Jun;176(6):2669-81. doi: 10.2353/ajpath.2010.090605. Epub 2010 Apr 15.
112. Patel B, etal., Br J Ophthalmol. 1994 Sep;78(9):714-8.
113. Peng SC, etal., Nucleic Acids Res. 2010 Nov;38(21):7446-57. doi: 10.1093/nar/gkq634. Epub 2010 Jul 17.
114. Petch LA, etal., Mol Cell Biol 1990 Jun;10(6):2973-82.
115. Piiper A, etal., J Biol Chem 2002 Nov 15;277(46):43623-30.
116. Pipeline to import KEGG annotations from KEGG into RGD
117. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
118. Pipeline to