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Gene: Egfr (epidermal growth factor receptor) Rattus norvegicus
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Symbol: Egfr
Name: epidermal growth factor receptor
Description: Exhibits several functions, including calmodulin binding activity; enzyme binding activity; and epidermal growth factor binding activity. Predicted to contribute to nitric-oxide synthase regulator activity. Involved in several processes, including animal organ development; cellular protein modification process; and positive regulation of cell communication. Localizes to several cellular components, including the apical plasma membrane; basolateral plasma membrane; and cytoplasmic vesicle. Used to study bronchiolo-alveolar adenocarcinoma and dilated cardiomyopathy. Biomarker of several diseases, including acute kidney failure; asthma; hypertension; lung disease (multiple); and peptic esophagitis. Human ortholog(s) of this gene implicated in several diseases, including breast carcinoma; colorectal cancer; lung cancer (multiple); pancreatic cancer; and prostate cancer. Orthologous to human EGFR (epidermal growth factor receptor); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; altered epidermal growth factor/neuregulin signaling pathway; cetuximab pharmacodynamics pathway; INTERACTS WITH (+)-pilocarpine; (R)-mevalonic acid; (R)-noradrenaline.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: avian erythroblastic leukemia viral (v-erbB) oncogene homolog; Egfr-related peptide; Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); Epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); ErbB-1; ERBB1; Errp
Orthologs:
Homo sapiens (human) : EGFR (epidermal growth factor receptor)  HGNC  Alliance
Mus musculus (house mouse) : Egfr (epidermal growth factor receptor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Egfr (epidermal growth factor receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : EGFR (epidermal growth factor receptor)
Canis lupus familiaris (dog) : EGFR (epidermal growth factor receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Egfr (epidermal growth factor receptor)
Sus scrofa (pig) : EGFR (epidermal growth factor receptor)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01499,919,485 - 100,104,136 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.014100,438,989 - 100,617,315 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41497,617,358 - 97,788,211 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1490,225,928 - 90,392,779 (+)NCBICelera
Cytogenetic Map14q22NCBI
RH 3.4 Map14 RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences