Egfr (epidermal growth factor receptor) - Rat Genome Database

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Gene: Egfr (epidermal growth factor receptor) Rattus norvegicus
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Symbol: Egfr
Name: epidermal growth factor receptor
RGD ID: 2543
Description: Enables several functions, including calmodulin binding activity; enzyme binding activity; and epidermal growth factor binding activity. Involved in several processes, including blood vessel diameter maintenance; positive regulation of cell communication; and positive regulation of cell population proliferation. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and cytoplasmic vesicle. Used to study bronchiolo-alveolar adenocarcinoma; dilated cardiomyopathy; and high grade glioma. Biomarker of several diseases, including Parkinsonism; acute kidney failure; lung disease (multiple); median neuropathy; and peptic esophagitis. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; lung non-small cell carcinoma (multiple); pancreatic cancer; prostate cancer; and pulmonary tuberculosis. Orthologous to human EGFR (epidermal growth factor receptor); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; altered epidermal growth factor/neuregulin signaling pathway; cetuximab pharmacodynamics pathway; INTERACTS WITH (+)-pilocarpine; (R)-noradrenaline; (S)-nicotine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: avian erythroblastic leukemia viral (v-erbB) oncogene homolog; Egfr-related peptide; Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); Epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); ErbB-1; ERBB1; Errp
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81495,378,626 - 95,551,358 (+)NCBIGRCr8
mRatBN7.21491,176,979 - 91,349,722 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1491,177,067 - 91,344,382 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1495,489,293 - 95,663,168 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01496,733,623 - 96,907,493 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01493,198,702 - 93,372,564 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01499,919,485 - 100,104,136 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1499,919,485 - 100,098,796 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014100,438,989 - 100,617,315 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41497,617,358 - 97,788,211 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1490,225,928 - 90,392,779 (+)NCBICelera
RH 3.4 Map14 RGD
Cytogenetic Map14q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IEP,ISO)
Acute Lung Injury  (ISO)
adenocarcinoma  (ISO)
adrenocortical carcinoma  (ISO)
Alcoholic Liver Diseases  (ISO)
Alzheimer's disease  (ISO)
Animal Mammary Neoplasms  (ISO)
aortic valve disease  (ISS)
aortic valve stenosis  (ISO)
arteriovenous malformations of the brain  (ISO)
asthma  (IEP,ISO)
autistic disorder  (ISO)
autosomal recessive polycystic kidney disease  (ISO)
Bannayan-Riley-Ruvalcaba syndrome  (ISO)
Bile Duct Neoplasms  (ISO)
Brain Neoplasms  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
bronchiolo-alveolar adenocarcinoma  (IMP,ISO)
carcinoma  (ISO)
Cardiomegaly  (ISO)
cerebral palsy  (ISO)
Chloracne  (ISO)
cholangiocarcinoma  (ISO)
chronic obstructive pulmonary disease  (IEP,ISO)
Colonic Neoplasms  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
Coronavirus infectious disease  (ISS)
Craniofacial Abnormalities  (ISO)
dementia  (ISO)
dermatitis  (ISO)
diabetes mellitus  (ISO)
diabetic retinopathy  (ISO)
dilated cardiomyopathy  (IMP,ISO)
Disease Progression  (ISO)
endometrial carcinoma  (ISO)
Endometrioid Carcinomas  (ISO)
endometriosis  (ISO)
esophageal carcinoma  (ISO)
Esophageal Neoplasms  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (IDA)
Experimental Mammary Neoplasms  (ISO)
familial adenomatous polyposis  (ISO)
Gallbladder Neoplasms  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
head and neck cancer  (ISO)
Head and Neck Neoplasms  (ISO)
head and neck squamous cell carcinoma  (ISO)
Helicobacter Infections  (ISO)
hepatocellular carcinoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
high grade glioma  (IMP,ISO)
Huntington's disease  (ISO)
Hyperplasia  (IEP)
hypertension  (IEP)
Immediate Hypersensitivity  (ISO)
Inflammation  (IMP)
Insulin Resistance  (ISO)
Laryngeal Neoplasms  (ISO)
laryngeal squamous cell carcinoma  (ISO)
Left Ventricular Hypertrophy  (IDA)
leiomyoma  (ISO)
liver cirrhosis  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
lung carcinoma  (ISO)
lung disease  (IEP)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
malignant mesothelioma  (ISO)
median neuropathy  (IEP)
Mesothelioma  (ISO)
Nasopharyngeal Neoplasms  (ISO)
Neonatal Inflammatory Skin and Bowel Disease 2  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplasm Recurrence, Local  (ISO)
obesity  (ISO)
oral squamous cell carcinoma  (ISO)
osteosarcoma  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
papilloma  (ISO)
papillomavirus infectious disease  (ISO)
Parkinson's disease  (ISO)
Parkinsonism  (IEP)
peptic esophagitis  (IEP)
Phyllodes Tumor  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary fibrosis  (IEP,ISO)
pulmonary hypertension  (ISO)
Pulmonary Hypertension, Hypoxia-Induced  (IMP)
pulmonary tuberculosis  (ISO)
rectal benign neoplasm  (ISO)
renal cell carcinoma  (ISO)
Right Ventricular Hypertrophy  (IMP)
schizophrenia  (ISO)
severe acute respiratory syndrome  (ISO)
Spinal Cord Injuries  (IEP,IMP)
squamous cell carcinoma  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
Tobacco Use Disorder  (IEP)
tongue squamous cell carcinoma  (ISO)
transitional cell carcinoma  (ISO)
type 1 diabetes mellitus  (IEP)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
Vascular Remodeling  (IMP)
Ventricular Fibrillation  (IMP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-Tetrandrine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(20R)-protopanaxadiol  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(R)-noradrenaline  (EXP)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP,ISO)
1,2,3,4,7,8-Hexachlorodibenzofuran  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,2-naphthoquinone  (ISO)
1,4-benzoquinone  (ISO)
1,4-naphthoquinone  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
16,16-dimethylprostaglandin E2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 17-glucosiduronic acid  (EXP)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,5-hexanedione  (EXP)
2-acetamidofluorene  (EXP)
2-deoxy-D-glucose  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxy-17beta-estradiol  (ISO)
2-nitrotoluene  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4'-epidoxorubicin  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
4-nitrotoluene  (ISO)
4-tert-Octylphenol  (EXP,ISO)
4-vinylcyclohexene dioxide  (ISO)
5,6alpha-epoxy-5alpha-cholestan-3beta-ol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-chrysenamine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP,ISO)
7-ketocholesterol  (EXP)
8-Br-cAMP  (ISO)
9,10-phenanthroquinone  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (EXP,ISO)
acrylamide  (ISO)
acteoside  (ISO)
actinomycin D  (EXP)
afatinib  (ISO)
afimoxifene  (ISO)
AH23848  (ISO)
AICA ribonucleotide  (ISO)
aldosterone  (EXP)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
alpha-naphthoflavone  (ISO)
alpha-pinene  (ISO)
alprenolol  (ISO)
aluminium oxide  (ISO)
AM-251  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amosite asbestos  (EXP,ISO)
amphibole asbestos  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimonite  (ISO)
antirheumatic drug  (ISO)
ANTU  (EXP)
apocynin  (ISO)
arachidonic acid  (EXP)
arecoline  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic acid  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
astragaloside IV  (EXP)
atenolol  (ISO)
atorvastatin calcium  (ISO)
ATP  (ISO)
atrazine  (EXP,ISO)
atropine  (ISO)
avobenzone  (ISO)
bafilomycin A1  (ISO)
baicalein  (ISO)
baicalin  (ISO)
benzamide  (ISO)
benzamidine  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzoic acid  (ISO)
berberine  (ISO)
betulin  (ISO)
betulinic acid  (ISO)
bicalutamide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bosutinib  (ISO)
butan-1-ol  (EXP)
butane-2,3-dione  (ISO)
butylated hydroxyanisole  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (EXP,ISO)
calcium atom  (EXP)
calcium silicate  (ISO)
calcium(0)  (EXP)
canertinib  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP,ISO)
carbon nanotube  (ISO)
carvacrol  (ISO)
carvedilol  (ISO)
casticin  (ISO)
CEDRELONE  (ISO)
celastrol  (ISO)
celecoxib  (EXP)
chloroprene  (EXP)
chloroquine  (EXP,ISO)
chlorothalonil  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysin  (ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (ISO)
cimetidine  (ISO)
Cinobufagin  (ISO)
ciprofibrate  (EXP)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crizotinib  (ISO)
crocidolite asbestos  (EXP,ISO)
Cryptotanshinone  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cyanocob(III)alamin  (ISO)
cycloheximide  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP,ISO)
cytochalasin B  (ISO)
cytochalasin D  (ISO)
dacomitinib  (ISO)
daidzein  (ISO)
DDE  (EXP)
deguelin  (ISO)
dehydroepiandrosterone  (ISO)
delphinidin  (ISO)
deoxycholic acid  (EXP,ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibenziodolium  (EXP,ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
Didecyldimethylammonium  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (EXP)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
disodium selenite  (ISO)
dobutamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
epoxiconazole  (EXP,ISO)
equol  (ISO)
Erionite  (EXP)
erlotinib hydrochloride  (ISO)
estrone  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
eugenol  (ISO)
everolimus  (ISO)
Evodiamine  (ISO)
fenamidone  (ISO)
fenofibrate  (ISO)
ferric oxide  (ISO)
fisetin  (ISO)
fluoranthene  (ISO)
fluoxetine  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formononetin  (ISO)
fulvestrant  (ISO)
furan  (EXP)
galangin  (ISO)
galaxolide  (ISO)
gallic acid  (ISO)
gedunin  (ISO)
gefitinib  (EXP,ISO)
geldanamycin  (EXP,ISO)
gemcitabine  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
glafenine  (EXP)
glutathione  (ISO)
glycine betaine  (ISO)
glyphosate  (ISO)
Goe 6976  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
helioxanthin  (ISO)
heparin  (ISO)
herbicide  (EXP)
hexachlorobenzene  (EXP,ISO)
hexadecanoic acid  (ISO)
histamine  (ISO)
hyaluronic acid  (ISO)
hydrogen chloride  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroxamic acid  (ISO)
hyperforin  (ISO)
hypochlorous acid  (ISO)
icariin  (EXP)
icariside II  (ISO)
ICI-164384  (ISO)
indole-3-methanol  (ISO)
indometacin  (EXP,ISO)
inulin  (ISO)
irbesartan  (EXP)
irinotecan  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoflavones  (EXP)
isoprenaline  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
JTE-013  (ISO)
ketoconazole  (EXP,ISO)
KN-93  (EXP,ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lansoprazole  (ISO)
lapatinib  (ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (ISO)
lead(0)  (EXP)
leflunomide  (ISO)
leukotriene C4  (ISO)
linalool  (ISO)
linuron  (EXP)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
lovastatin  (ISO)
luteolin  (ISO)
LY294002  (ISO)
Maduramicin  (EXP)
magnesium dichloride  (ISO)
Malabaricone C  (ISO)
manganese(II) chloride  (EXP,ISO)
melittin  (ISO)
menadione  (EXP)
mercury dichloride  (EXP,ISO)
metamizole sodium  (EXP)
methapyrilene  (EXP)
methidathion  (ISO)
methimazole  (EXP)
methotrexate  (EXP,ISO)
methoxychlor  (EXP,ISO)
Methylazoxymethanol acetate  (EXP)
methylmercury chloride  (ISO)
mevalonic acid  (EXP)
microcystin-LR  (ISO)
mifepristone  (EXP,ISO)
MK-2206  (ISO)
monosodium L-glutamate  (EXP,ISO)
myo-inositol hexakisphosphate  (ISO)
myricetin  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylcysteamine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-methylformamide  (ISO)
N-methylnicotinate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naphthalene  (ISO)
naringin  (ISO)
nefazodone  (EXP)
neocuproine  (ISO)
neratinib  (ISO)
nevirapine  (ISO)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (EXP)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nobiletin  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
oleic acid  (ISO)
omipalisib  (ISO)
oridonin  (ISO)
osimertinib  (ISO)
ouabain  (ISO)
oxaliplatin  (EXP,ISO)
oxazepam  (ISO)
oxytocin  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
p-tert-Amylphenol  (EXP,ISO)
paclitaxel  (ISO)
Paeonol  (EXP)
pamidronate  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
parathion  (ISO)
paroxetine  (ISO)
PD 168393  (EXP,ISO)
pentane-2,3-dione  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
PHA-665752  (ISO)
phenobarbital  (EXP,ISO)
phenylarsine oxide  (ISO)
phenylephrine  (EXP,ISO)
phenylmercury acetate  (ISO)
PhIP  (EXP)
phloretin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phorone  (ISO)
phosphoramidon  (ISO)
Phytolaccoside E  (ISO)
piperonyl butoxide  (ISO)
pirfenidone  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (EXP,ISO)
platycodin D  (ISO)
ponatinib  (ISO)
potassium chromate  (ISO)
primaquine  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
progesterone  (EXP,ISO)
propofol  (ISO)
propranolol  (ISO)
prostaglandin E2  (ISO)
protein kinase inhibitor  (ISO)
protoporphyrin  (ISO)
Ptaquiloside  (ISO)
pterostilbene  (ISO)
pyocyanine  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
quinazolines  (ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
raloxifene  (EXP,ISO)
ranitidine  (EXP)
reactive oxygen species  (EXP,ISO)
resveratrol  (ISO)
romidepsin  (ISO)
rotenone  (EXP)
rottlerin  (ISO)
ruthenium atom  (ISO)
rutin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
scopolamine  (EXP)
selenium atom  (ISO)
selenomethionine  (ISO)
senecionine  (ISO)
sepantronium  (ISO)
serpentine asbestos  (ISO)
sertraline  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium fluoride  (ISO)
sodium hydroxide  (ISO)
sorafenib  (ISO)
sotorasib  (ISO)
sphingosine 1-phosphate  (ISO)
staurosporine  (ISO)
stilbenoid  (ISO)
streptozocin  (EXP)
SU6656  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sulfasalazine  (ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (EXP,ISO)
Sulpyrine  (EXP)
sunitinib  (ISO)
suramin  (EXP)
taiwanin C  (ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
taurocholic acid  (ISO)
tephrosin  (ISO)
Terfenadine  (ISO)
teriflunomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
tetramethylpyrazine  (ISO)
tetraphene  (ISO)
tetrathiomolybdate(2-)  (ISO)
thapsigargin  (ISO)
theaflavin  (ISO)
thioacetamide  (EXP)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP,ISO)
torin 1  (ISO)
trans-piceid  (ISO)
triamterene  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (ISO)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
trovafloxacin  (ISO)
Tubeimoside II  (ISO)
tyrphostin AG 1478  (EXP,ISO)
U-73122  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
ursolic acid  (ISO)
UTP  (EXP)
valdecoxib  (EXP)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
vandetanib  (ISO)
veliparib  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (EXP,ISO)
WIN 55212-2  (ISO)
wortmannin  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc sulfate  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
astrocyte activation  (IMP)
cell morphogenesis  (ISO)
cell population proliferation  (ISO)
cell surface receptor signaling pathway  (ISO)
cell-cell adhesion  (ISO)
cellular response to amino acid stimulus  (ISO)
cellular response to cadmium ion  (ISO)
cellular response to dexamethasone stimulus  (IEP)
cellular response to epidermal growth factor stimulus  (IDA)
cellular response to estradiol stimulus  (ISO)
cellular response to growth factor stimulus  (IEP,ISO)
cellular response to mechanical stimulus  (IEP)
cellular response to reactive oxygen species  (ISO)
cellular response to xenobiotic stimulus  (IEP)
cerebral cortex cell migration  (ISO)
circadian rhythm  (IEP)
digestive tract morphogenesis  (ISO)
diterpenoid metabolic process  (IEP)
embryonic placenta development  (ISO)
epidermal growth factor receptor signaling pathway  (IDA,IMP,ISO)
epidermis development  (ISO)
epithelial cell proliferation  (ISO)
ERBB2-EGFR signaling pathway  (ISO)
eyelid development in camera-type eye  (ISO)
hair follicle development  (IEP,ISO)
hydrogen peroxide metabolic process  (IEP)
intracellular signal transduction  (IDA)
learning or memory  (IDA)
liver development  (IEP)
liver regeneration  (IEP,IMP)
lung development  (IEP)
midgut development  (IEP)
morphogenesis of an epithelial fold  (ISO)
negative regulation of apoptotic process  (IBA,IMP,ISO)
negative regulation of cardiocyte differentiation  (ISO)
negative regulation of epidermal growth factor receptor signaling pathway  (ISO)
negative regulation of mitotic cell cycle  (IMP)
negative regulation of protein catabolic process  (ISO)
neurogenesis  (IBA)
neuron projection morphogenesis  (IMP)
ovulation cycle  (IMP)
peptidyl-tyrosine phosphorylation  (IDA)
positive regulation of bone resorption  (IMP)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of cell growth  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA repair  (ISO)
positive regulation of DNA replication  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of epithelial cell proliferation  (IBA,ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of G1/S transition of mitotic cell cycle  (ISO)
positive regulation of glial cell proliferation  (IMP)
positive regulation of MAPK cascade  (IMP)
positive regulation of miRNA transcription  (ISO)
positive regulation of mucus secretion  (IMP)
positive regulation of non-canonical NF-kappaB signal transduction  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of phosphorylation  (ISO)
positive regulation of prolactin secretion  (IDA)
positive regulation of protein localization to plasma membrane  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of smooth muscle cell proliferation  (IMP)
positive regulation of superoxide anion generation  (IMP)
positive regulation of synaptic transmission, glutamatergic  (IMP)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of vasoconstriction  (IMP)
protein autophosphorylation  (IDA)
receptor-mediated endocytosis  (ISO)
regulation of cell population proliferation  (ISO)
regulation of ERK1 and ERK2 cascade  (ISO)
regulation of JNK cascade  (ISO)
regulation of peptidyl-tyrosine phosphorylation  (ISO)
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
response to calcium ion  (IMP)
response to cobalamin  (IEP)
response to estradiol  (IEP)
response to hydroxyisoflavone  (IEP)
response to lipid  (IEP)
response to organic cyclic compound  (IEP)
response to oxidative stress  (IEP)
response to UV-A  (ISO)
salivary gland morphogenesis  (ISO)
signal transduction  (ISO)
tongue development  (IEP)
translation  (IDA)
vasodilation  (IMP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
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114. A novel role of CPEB3 in regulating EGFR gene transcription via association with Stat5b in neurons. Peng SC, etal., Nucleic Acids Res. 2010 Nov;38(21):7446-57. doi: 10.1093/nar/gkq634. Epub 2010 Jul 17.
115. A truncated, secreted form of the epidermal growth factor receptor is encoded by an alternatively spliced transcript in normal rat tissue. Petch LA, etal., Mol Cell Biol 1990 Jun;10(6):2973-82.
116. Cyclic AMP induces transactivation of the receptors for epidermal growth factor and nerve growth factor, thereby modulating activation of MAP kinase, Akt, and neurite outgrowth in PC12 cells. Piiper A, etal., J Biol Chem 2002 Nov 15;277(46):43623-30.
117. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
118. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
119. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
120. Inhibitory effect of antisense epidermal growth factor receptor RNA on the proliferation of rat C6 glioma cells in vitro and in vivo. Pu P, etal., J Neurosurg. 2000 Jan;92(1):132-9. doi: 10.3171/jns.2000.92.1.0132.
121. Inhibition of EGFR/MAPK signaling reduces microglial inflammatory response and the associated secondary damage in rats after spinal cord injury. Qu WS, etal., J Neuroinflammation. 2012 Jul 23;9:178. doi: 10.1186/1742-2094-9-178.
122. c-Cbl ubiquitin ligase regulates focal adhesion protein turnover and myofibril degeneration induced by neutrophil protease cathepsin G. Rafiq K, etal., J Biol Chem. 2012 Feb 17;287(8):5327-39. doi: 10.1074/jbc.M111.307009. Epub 2011 Dec 27.
123. Immunomodulatory activity of fucoidan against aspirin-induced gastric mucosal damage in rats. Raghavendran HR, etal., Int Immunopharmacol. 2011 Feb;11(2):157-63. Epub 2010 Nov 26.
124. Lapatinib versus hormone therapy in patients with advanced renal cell carcinoma: a randomized phase III clinical trial. Ravaud A, etal., J Clin Oncol. 2008 May 10;26(14):2285-91.
125. GOA pipeline RGD automated data pipeline
126. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
127. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
128. The NADPH oxidase inhibitor VAS2870 impairs cell growth and enhances TGF-beta-induced apoptosis of liver tumor cells. Sancho P and Fabregat I, Biochem Pharmacol. 2011 Apr 1;81(7):917-24. Epub 2011 Jan 26.
129. Somatic mutations of signaling genes in non-small-cell lung cancer. Sanders HR and Albitar M, Cancer Genet Cytogenet. 2010 Nov;203(1):7-15.
130. The effect of combination anti-endothelial growth factor receptor and anti-vascular endothelial growth factor receptor 2 targeted therapy on lymph node metastasis: a study in an orthotopic nude mouse model of squamous cell carcinoma of the oral tongue. Sano D, etal., Arch Otolaryngol Head Neck Surg. 2009 Apr;135(4):411-20. doi: 10.1001/archoto.2009.14.
131. Activation of the MEK5/ERK5 cascade is responsible for biliary dysgenesis in a rat model of Caroli's disease. Sato Y, etal., Am J Pathol. 2005 Jan;166(1):49-60.
132. The emergence of ErbB2 expression in cultured rat hepatocytes correlates with enhanced and diversified EGF-mediated signaling. Scheving LA, etal., Am J Physiol Gastrointest Liver Physiol. 2006 Jul;291(1):G16-25.
133. Dexamethasone modulates ErbB tyrosine kinase expression and signaling through multiple and redundant mechanisms in cultured rat hepatocytes. Scheving LA, etal., Am J Physiol Gastrointest Liver Physiol. 2007 Sep;293(3):G552-9. Epub 2007 Jun 21.
134. The epidermal growth factor receptor inhibitor AG1478 inhibits eosinophilic inflammation in upper airways. Shimizu S, etal., Clin Immunol. 2018 Mar;188:1-6. doi: 10.1016/j.clim.2017.11.010. Epub 2017 Nov 26.
135. The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development. Sibilia M, etal., Cell 2000 Jul 21;102(2):211-20.
136. Epidermal growth factor receptor inhibition downregulates Helicobacter pylori-induced epithelial inflammatory responses, DNA damage and gastric carcinogenesis. Sierra JC, etal., Gut. 2018 Jul;67(7):1247-1260. doi: 10.1136/gutjnl-2016-312888. Epub 2017 May 4.
137. Autocrine, paracrine and juxtacrine signaling by EGFR ligands. Singh AB and Harris RC, Cell Signal. 2005 Oct;17(10):1183-93.
138. Epidermal growth factor receptor expression in demented and aged human brain. Styren SD, etal., Brain Res. 1990 Apr 2;512(2):347-52.
139. A kinase cascade leading to Rab11-FIP5 controls transcytosis of the polymeric immunoglobulin receptor. Su T, etal., Nat Cell Biol. 2010 Dec;12(12):1143-53. Epub 2010 Oct 31.
140. Inhibition of EGF signaling protects the diabetic retina from insulin-induced vascular leakage. Sugimoto M, etal., Am J Pathol. 2013 Sep;183(3):987-95. doi: 10.1016/j.ajpath.2013.05.017. Epub 2013 Jul 3.
141. Phyllodes tumor of the breast: EGFR family expression and relation to clinicopathological features. Suo Z and Nesland JM, Ultrastruct Pathol. 2000 Nov-Dec;24(6):371-81.
142. A disintegrin and metalloprotease 17 mediates neointimal hyperplasia in vasculature. Takaguri A, etal., Hypertension. 2011 Apr;57(4):841-5. Epub 2011 Feb 28.
143. Sigma-1 receptors potentiate epidermal growth factor signaling towards neuritogenesis in PC12 cells: potential relation to lipid raft reconstitution. Takebayashi M, etal., Synapse. 2004 Aug;53(2):90-103.
144. Sphingosine 1-phosphate transactivates the platelet-derived growth factor beta receptor and epidermal growth factor receptor in vascular smooth muscle cells. Tanimoto T, etal., Circ Res. 2004 Apr 30;94(8):1050-8. Epub 2004 Mar 25.
145. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
146. Developmental regulation of epidermal growth factor receptor kinase in rat intestine. Thompson JF, etal., Gastroenterology. 1994 Nov;107(5):1278-87.
147. Cross-talk between the calcium-sensing receptor and the epidermal growth factor receptor in Rat-1 fibroblasts. Tomlins SA, etal., Exp Cell Res. 2005 Aug 15;308(2):439-45.
148. Clinical pharmacokinetics of tyrosine kinase inhibitors. van Erp NP, etal., Cancer Treat Rev. 2009 Dec;35(8):692-706. Epub 2009 Sep 5.
149. Overactive Epidermal Growth Factor Receptor Signaling Leads to Increased Fibrosis after Severe Acute Respiratory Syndrome Coronavirus Infection. Venkataraman T, etal., J Virol. 2017 May 26;91(12). pii: JVI.00182-17. doi: 10.1128/JVI.00182-17. Print 2017 Jun 15.
150. EGF receptor transactivation is obligatory for protein synthesis stimulation by G protein-coupled receptors. Voisin L, etal., Am J Physiol Cell Physiol 2002 Aug;283(2):C446-55.
151. Proteomic discovery of genistein action in the rat mammary gland. Wang J, etal., J Proteome Res. 2011 Apr 1;10(4):1621-31. Epub 2011 Feb 22.
152. Epidermal growth factor receptor is a preferred target for treating amyloid-beta-induced memory loss. Wang L, etal., Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16743-8. doi: 10.1073/pnas.1208011109. Epub 2012 Sep 27.
153. The p53/miR-193a/EGFR feedback loop function as a driving force for non-small cell lung carcinoma tumorigenesis. Wang W, etal., Ther Adv Med Oncol. 2019 May 23;11:1758835919850665. doi: 10.1177/1758835919850665. eCollection 2019.
154. The EGFR tyrosine kinase inhibitor tyrphostin AG-1478 causes hypomagnesemia and cardiac dysfunction. Weglicki WB, etal., Can J Physiol Pharmacol. 2012 Aug;90(8):1145-9. doi: 10.1139/y2012-023. Epub 2012 May 30.
155. Monoclonal antibodies against EGFRvIII are tumor specific and react with breast and lung carcinomas and malignant gliomas. Wikstrand CJ, etal., Cancer Res. 1995 Jul 15;55(14):3140-8.
156. [Bronchiolar-alveolar carcinoma: From concept to innovative therapeutic strategies.] Wislez M, etal., Presse Med. 2011 Apr;40(4P1):389-397. Epub 2011 Mar 17.
157. Pancreatic cancer: molecular pathogenesis and new therapeutic targets. Wong HH and Lemoine NR, Nat Rev Gastroenterol Hepatol. 2009 Jul;6(7):412-22. Epub 2009 Jun 9.
158. Theaflavins Extracted from Black Tea Inhibit Airway Mucous Hypersecretion Induced by Cigarette Smoke in Rats. Wu H, etal., Inflammation. 2011 Apr 8.
159. Nuclear expression of epidermal growth factor receptor is a novel prognostic value in patients with ovarian cancer. Xia W, etal., Mol Carcinog. 2009 Jul;48(7):610-7.
160. PFOS prenatal exposure induce mitochondrial injury and gene expression change in hearts of weaned SD rats. Xia W, etal., Toxicology. 2011 Mar 28;282(1-2):23-9. Epub 2011 Jan 18.
161. Versican G3 domain regulates neurite growth and synaptic transmission of hippocampal neurons by activation of epidermal growth factor receptor. Xiang YY, etal., J Biol Chem. 2006 Jul 14;281(28):19358-68. Epub 2006 Apr 28.
162. Impaired Epithelial Wound Healing and EGFR Signaling Pathways in the Corneas of Diabetic Rats. Xu K and Yu FS, Invest Ophthalmol Vis Sci. 2011 Feb 17.
163. Endocytic Adaptor Protein HIP1R Controls Intracellular Trafficking of Epidermal Growth Factor Receptor in Neuronal Dendritic Development. Yang Q, etal., Front Mol Neurosci. 2018 Dec 6;11:447. doi: 10.3389/fnmol.2018.00447. eCollection 2018.
164. Biologic Evaluation of Diabetes and Local Recurrence in Non-Small Cell Lung Cancer. Yang X, etal., Pathol Oncol Res. 2017 Jan;23(1):73-77. doi: 10.1007/s12253-016-0086-1. Epub 2016 Jul 13.
165. Activating KRAS mutations and overexpression of epidermal growth factor receptor as independent predictors in metastatic colorectal cancer patients treated with cetuximab. Yen LC, etal., Ann Surg. 2010 Feb;251(2):254-60.
166. Enhanced expression of EGF receptor in a model of salt-sensitive hypertension. Ying WZ and Sanders PW, Am J Physiol Renal Physiol. 2005 Aug;289(2):F314-21. Epub 2005 Apr 12.
167. Targeting epidermal growth factor receptor: central signaling kinase in lung cancer. Yoshida T, etal., Biochem Pharmacol. 2010 Sep 1;80(5):613-23. Epub 2010 May 24.
168. Gene polymorphism of epidermal growth factor receptor and airway hyperresponsiveness in young allergic subjects without respiratory symptoms. Yoshikawa T, etal., Med Sci Monit. 2010 Apr 1;16(4):CR163-171.
169. Formononetin inhibits tumor growth by suppression of EGFR-Akt-Mcl-1 axis in non-small cell lung cancer. Yu X, etal., J Exp Clin Cancer Res. 2020 Apr 10;39(1):62. doi: 10.1186/s13046-020-01566-2.
170. Cloning of a novel EGFR-related peptide: a putative negative regulator of EGFR. Yu Y, etal., Am J Physiol Cell Physiol 2001 May;280(5):C1083-9.
171. Transactivation of epidermal growth factor receptor mediates catecholamine-induced growth of vascular smooth muscle. Zhang H, etal., Circ Res. 2004 Nov 12;95(10):989-97. Epub 2004 Oct 14.
172. Crosstalk Between MAPK/ERK and PI3K/AKT Signal Pathways During Brain Ischemia/Reperfusion. Zhou J, etal., ASN Neuro. 2015 Oct 6;7(5). pii: 7/5/1759091415602463. doi: 10.1177/1759091415602463. Print 2015 Sep-Oct.
173. Activation of epidermal growth factor receptor during corneal epithelial migration. Zieske JD, etal., Invest Ophthalmol Vis Sci. 2000 May;41(6):1346-55.
Additional References at PubMed
PMID:7588596   PMID:7618084   PMID:7641815   PMID:7678348   PMID:7723235   PMID:7736574   PMID:8550620   PMID:8702723   PMID:8947489   PMID:9030684   PMID:9722539   PMID:10521784  
PMID:10534613   PMID:10572067   PMID:10702298   PMID:11071895   PMID:11818567   PMID:11940581   PMID:12009895   PMID:12435727   PMID:12524172   PMID:12579211   PMID:12646923   PMID:12767047  
PMID:12772780   PMID:12808090   PMID:12828935   PMID:12829718   PMID:12874275   PMID:12876381   PMID:12880866   PMID:12939263   PMID:12966092   PMID:14627647   PMID:14645255   PMID:14697673  
PMID:14702346   PMID:14712229   PMID:15039424   PMID:15082764   PMID:15140944   PMID:15292396   PMID:15314156   PMID:15328014   PMID:15337756   PMID:15371442   PMID:15389569   PMID:15465819  
PMID:15467833   PMID:15556944   PMID:15563939   PMID:15626689   PMID:15695332   PMID:15710429   PMID:15767552   PMID:15838279   PMID:15856020   PMID:15899872   PMID:16019433   PMID:16083858  
PMID:16129559   PMID:16135076   PMID:16239374   PMID:16543144   PMID:16554368   PMID:16651634   PMID:16751223   PMID:16777603   PMID:16804967   PMID:16951163   PMID:17031671   PMID:17115032  
PMID:17148612   PMID:17172655   PMID:17177598   PMID:17182860   PMID:17272394   PMID:17307332   PMID:17349580   PMID:17350025   PMID:17363458   PMID:17426222   PMID:17446044   PMID:17510240  
PMID:17560206   PMID:17599051   PMID:17615176   PMID:17655843   PMID:17686994   PMID:17714434   PMID:17825525   PMID:17881501   PMID:17959830   PMID:17962899   PMID:17975113   PMID:17985142  
PMID:18042729   PMID:18070883   PMID:18177419   PMID:18195168   PMID:18216199   PMID:18216322   PMID:18271921   PMID:18282556   PMID:18314882   PMID:18330891   PMID:18413814   PMID:18483258  
PMID:18571897   PMID:18653647   PMID:18656477   PMID:18667434   PMID:18803016   PMID:18832099   PMID:19127349   PMID:19225541   PMID:19245830   PMID:19254952   PMID:19283661   PMID:19306296  
PMID:19326266   PMID:19356729   PMID:19410658   PMID:19416119   PMID:19420116   PMID:19470835   PMID:19553664   PMID:19563760   PMID:19570028   PMID:19574994   PMID:19577003   PMID:19578070  
PMID:19583703   PMID:19605547   PMID:19614676   PMID:19650109   PMID:19684181   PMID:19783665   PMID:19885844   PMID:20007378   PMID:20009084   PMID:20029029   PMID:20029031   PMID:20036247  
PMID:20110336   PMID:20208556   PMID:20302655   PMID:20359299   PMID:20373517   PMID:20388488   PMID:20462955   PMID:20466046   PMID:20471394   PMID:20551055   PMID:20571033   PMID:20664065  
PMID:20826789   PMID:20852045   PMID:20878056   PMID:20977469   PMID:21196724   PMID:21278786   PMID:21342330   PMID:21423176   PMID:21480528   PMID:21482778   PMID:21536676   PMID:21673316  
PMID:21791570   PMID:21806601   PMID:21832070   PMID:21856923   PMID:21883215   PMID:21887704   PMID:21921987   PMID:21954875   PMID:22048644   PMID:22214165   PMID:22227249   PMID:22232519  
PMID:22245996   PMID:22281474   PMID:22285193   PMID:22298428   PMID:22579287   PMID:22645946   PMID:22711986   PMID:22719997   PMID:22732145   PMID:22781707   PMID:22935817   PMID:23069713  
PMID:23273428   PMID:23335245   PMID:23374349   PMID:23380500   PMID:23382219   PMID:23418353   PMID:23432726   PMID:23436906   PMID:23537435   PMID:23605002   PMID:23636329   PMID:23656597  
PMID:23918928   PMID:24135280   PMID:24194502   PMID:24684506   PMID:24854121   PMID:25002532   PMID:25013941   PMID:25201632   PMID:25232008   PMID:25330173   PMID:25448158   PMID:25468996  
PMID:25661317   PMID:25666625   PMID:25678558   PMID:25759388   PMID:25771448   PMID:25788532   PMID:25813982   PMID:26021843   PMID:26204818   PMID:26209152   PMID:26241029   PMID:26399481  
PMID:26493720   PMID:26514923   PMID:26598506   PMID:26683191   PMID:26707876   PMID:26771606   PMID:26867523   PMID:26928584   PMID:26985693   PMID:27021728   PMID:27057632   PMID:27226351  
PMID:27317889   PMID:27342773   PMID:27414783   PMID:27443256   PMID:27606614   PMID:27744404   PMID:28031526   PMID:28056182   PMID:28759036   PMID:28943431   PMID:29673456   PMID:30352949  
PMID:30356069   PMID:30792526   PMID:31115490   PMID:31215332   PMID:31247223   PMID:31462148   PMID:31473246   PMID:31622577   PMID:31882563   PMID:31980649   PMID:32111605   PMID:32223947  
PMID:32586178   PMID:32906765   PMID:34252414   PMID:35701740   PMID:36655849   PMID:38358361  


Genomics

Comparative Map Data
Egfr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81495,378,626 - 95,551,358 (+)NCBIGRCr8
mRatBN7.21491,176,979 - 91,349,722 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1491,177,067 - 91,344,382 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1495,489,293 - 95,663,168 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01496,733,623 - 96,907,493 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01493,198,702 - 93,372,564 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01499,919,485 - 100,104,136 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1499,919,485 - 100,098,796 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014100,438,989 - 100,617,315 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41497,617,358 - 97,788,211 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1490,225,928 - 90,392,779 (+)NCBICelera
RH 3.4 Map14 RGD
Cytogenetic Map14q22NCBI
EGFR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38755,019,017 - 55,211,628 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl755,019,017 - 55,211,628 (+)EnsemblGRCh38hg38GRCh38
GRCh37755,086,710 - 55,279,321 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36755,054,219 - 55,242,525 (+)NCBINCBI36Build 36hg18NCBI36
Build 34754,860,933 - 55,012,947NCBI
Celera755,192,332 - 55,380,657 (+)NCBICelera
Cytogenetic Map7p11.2NCBI
HuRef754,924,934 - 55,112,834 (+)NCBIHuRef
CHM1_1755,089,165 - 55,277,398 (+)NCBICHM1_1
T2T-CHM13v2.0755,178,937 - 55,372,056 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2755,092,507 - 55,280,831 (+)NCBI
Egfr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391116,700,153 - 16,868,158 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1116,702,203 - 16,868,158 (+)EnsemblGRCm39 Ensembl
GRCm381116,752,203 - 16,913,907 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1116,752,203 - 16,918,158 (+)EnsemblGRCm38mm10GRCm38
MGSCv371116,652,206 - 16,813,910 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361116,652,206 - 16,813,909 (+)NCBIMGSCv36mm8
Celera1117,126,474 - 17,287,898 (+)NCBICelera
Cytogenetic Map11A2NCBI
cM Map119.41NCBI
Egfr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955456321,222 - 456,431 (-)NCBIChiLan1.0ChiLan1.0
EGFR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2659,852,898 - 60,046,419 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17108,177,622 - 108,371,205 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0755,614,042 - 55,807,285 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1756,048,212 - 56,117,642 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl756,046,296 - 56,111,615 (+)Ensemblpanpan1.1panPan2
EGFR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1185,983,669 - 6,044,092 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl185,982,770 - 6,042,631 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha185,693,578 - 5,890,886 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0185,890,289 - 6,087,722 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl185,890,228 - 6,085,544 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1185,880,554 - 6,077,776 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0185,854,700 - 6,051,915 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0185,960,845 - 6,158,207 (+)NCBIUU_Cfam_GSD_1.0
Egfr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118109,328,850 - 109,524,551 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936678365,834 - 436,528 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936678365,005 - 560,546 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EGFR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9139,300,022 - 139,475,589 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19139,302,410 - 139,474,632 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
EGFR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1213,664,622 - 3,853,492 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl213,666,339 - 3,853,239 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606218,644,141 - 18,836,149 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Egfr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624740589,606 - 713,271 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624740584,133 - 713,205 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Egfr
1036 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:39
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000006087
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147341532392554092Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147341532392554092Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532395876975Rat
631213Bw60Body weight QTL604.51retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)147995092195876975Rat
4889951Bss92Bone structure and strength QTL 923.9tibia area (VT:1000281)tibia-fibula cortical bone total cross-sectional area (CMO:0001721)148205747195876975Rat

Markers in Region
D14Rat21  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21491,195,268 - 91,195,399 (+)MAPPERmRatBN7.2
Rnor_6.01499,950,361 - 99,950,491NCBIRnor6.0
Rnor_5.014100,588,363 - 100,588,493UniSTSRnor5.0
RGSC_v3.41497,637,357 - 97,637,488RGDRGSC3.4
RGSC_v3.41497,637,358 - 97,637,488UniSTSRGSC3.4
RGSC_v3.11497,656,503 - 97,656,633RGD
Celera1490,243,773 - 90,243,903UniSTS
RH 3.4 Map14667.4UniSTS
RH 3.4 Map14667.4RGD
RH 2.0 Map14652.3RGD
SHRSP x BN Map1464.35RGD
Cytogenetic Map14q22UniSTS
X78987  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21491,344,143 - 91,344,304 (+)MAPPERmRatBN7.2
Rnor_6.014100,098,558 - 100,098,718NCBIRnor6.0
Rnor_5.014100,439,065 - 100,439,225UniSTSRnor5.0
RGSC_v3.41497,787,975 - 97,788,135UniSTSRGSC3.4
Celera1490,392,543 - 90,392,703UniSTS
Cytogenetic Map14q22UniSTS
RH142192  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21491,175,679 - 91,175,865 (+)MAPPERmRatBN7.2
Rnor_6.01499,918,098 - 99,918,283NCBIRnor6.0
Rnor_5.014100,618,517 - 100,618,702UniSTSRnor5.0
RGSC_v3.41497,615,971 - 97,616,156UniSTSRGSC3.4
Celera1490,224,541 - 90,224,726UniSTS
RH 3.4 Map14674.9UniSTS
Cytogenetic Map14q22UniSTS
BF396931  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21491,200,050 - 91,200,243 (+)MAPPERmRatBN7.2
Rnor_6.01499,955,143 - 99,955,335NCBIRnor6.0
Rnor_5.014100,583,519 - 100,583,711UniSTSRnor5.0
RGSC_v3.41497,642,140 - 97,642,332UniSTSRGSC3.4
Celera1490,248,559 - 90,248,751UniSTS
RH 3.4 Map14674.2UniSTS
Cytogenetic Map14q22UniSTS
AA996669  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21491,344,514 - 91,344,625 (+)MAPPERmRatBN7.2
Rnor_6.014100,098,929 - 100,099,039NCBIRnor6.0
Rnor_5.014100,438,744 - 100,438,854UniSTSRnor5.0
RGSC_v3.41497,788,346 - 97,788,456UniSTSRGSC3.4
Celera1490,392,914 - 90,393,024UniSTS
RH 3.4 Map14674.8UniSTS
Cytogenetic Map14q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 26 23 3 23 2 2 8 20 16 8 2
Low 3 40 31 18 16 18 6 9 66 15 20 3 6
Below cutoff 3 5

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001393707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_031507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB025197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB079120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC098180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF142153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM801041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM801042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M37394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U52529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000006087   ⟹   ENSRNOP00000006087
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1491,177,067 - 91,344,382 (+)Ensembl
Rnor_6.0 Ensembl1499,919,485 - 100,098,796 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000097681   ⟹   ENSRNOP00000080460
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1491,286,480 - 91,344,382 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111139   ⟹   ENSRNOP00000078445
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1491,286,480 - 91,302,348 (+)Ensembl
RefSeq Acc Id: NM_001393707   ⟹   NP_001380636
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81495,378,626 - 95,551,358 (+)NCBI
mRatBN7.21491,176,979 - 91,349,722 (+)NCBI
RefSeq Acc Id: NM_031507   ⟹   NP_113695
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81495,378,626 - 95,551,358 (+)NCBI
mRatBN7.21491,176,979 - 91,349,722 (+)NCBI
Rnor_6.01499,919,485 - 100,098,794 (+)NCBI
Rnor_5.014100,438,989 - 100,617,315 (-)NCBI
RGSC_v3.41497,617,358 - 97,788,211 (+)RGD
Celera1490,225,928 - 90,392,779 (+)RGD
Sequence:
RefSeq Acc Id: NP_113695   ⟸   NM_031507
- Peptide Label: isoform 1 precursor
- UniProtKB: A6JPX8 (UniProtKB/TrEMBL),   E7CXR8 (UniProtKB/TrEMBL),   G3V6K6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000006087   ⟸   ENSRNOT00000006087
RefSeq Acc Id: ENSRNOP00000080460   ⟸   ENSRNOT00000097681
RefSeq Acc Id: ENSRNOP00000078445   ⟸   ENSRNOT00000111139
RefSeq Acc Id: NP_001380636   ⟸   NM_001393707
- Peptide Label: isoform 2 precursor
- UniProtKB: E7CXR8 (UniProtKB/TrEMBL),   G3V6K6 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V6K6-F1-model_v2 AlphaFold G3V6K6 1-1209 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2543 AgrOrtholog
BioCyc Gene G2FUF-14941 BioCyc
Ensembl Genes ENSRNOG00000004332 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006087 ENTREZGENE
  ENSRNOT00000006087.3 UniProtKB/TrEMBL
  ENSRNOT00000097681.1 UniProtKB/TrEMBL
  ENSRNOT00000111139.1 UniProtKB/TrEMBL
Gene3D-CATH 3.80.20.20 UniProtKB/TrEMBL
  6.10.250.2930 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro EGF_rcpt_L UniProtKB/TrEMBL
  Egfr_JX_dom UniProtKB/TrEMBL
  Furin-like_Cys-rich_dom UniProtKB/TrEMBL
  Furin_repeat UniProtKB/TrEMBL
  GF_recep_IV UniProtKB/TrEMBL
  Growth_fac_rcpt UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Rcpt_L-dom_sf UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  TM_ErbB1 UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_EGF/ERB/XmrK_rcpt UniProtKB/TrEMBL
KEGG Report rno:24329 UniProtKB/TrEMBL
NCBI Gene 24329 ENTREZGENE
PANTHER EPIDERMAL GROWTH FACTOR RECEPTOR UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/TrEMBL
Pfam Furin-like UniProtKB/TrEMBL
  GF_recep_IV UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
  Recep_L_domain UniProtKB/TrEMBL
  TM_ErbB1 UniProtKB/TrEMBL
PharmGKB EGFR RGD
PhenoGen Egfr PhenoGen
PIRSF TyrPK_EGF-R UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004332 RatGTEx
SMART SM00261 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP Grow_fac_recept UniProtKB/TrEMBL
  Kinase_like UniProtKB/TrEMBL
  L domain-like UniProtKB/TrEMBL
TIGR TC215615
  TC230053
UniProt A0A8I5ZMJ2_RAT UniProtKB/TrEMBL
  A0A8I5ZQB9_RAT UniProtKB/TrEMBL
  A6JPX8 ENTREZGENE, UniProtKB/TrEMBL
  A6JPX9_RAT UniProtKB/TrEMBL
  A8IP97_RAT UniProtKB/TrEMBL
  E7CXR8 ENTREZGENE, UniProtKB/TrEMBL
  E7CXR9_RAT UniProtKB/TrEMBL
  G3V6K6 ENTREZGENE, UniProtKB/TrEMBL
  Q9ESE0_RAT UniProtKB/TrEMBL
  Q9QX70_RAT UniProtKB/TrEMBL
  Q9WTS1_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Egfr  epidermal growth factor receptor      Symbol and Name status set to approved 1299863 APPROVED
2002-06-10 Egfr  epidermal growth factor receptor      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease may affect proliferation in colon cancer 67994
gene_expression expressed in the small intestine, colon, liver, gastric mucosa, and other tissues 69942
gene_expression expressed during the onset of puberty 70386
gene_expression upregulated during female reproduction 70386
gene_process promotes cell differentiation and proliferation 67994
gene_process promotes protein synthesis by G protein-coupled receptor (GPCR) agonists in vascular smooth muscle cells (VSMC) 625656
gene_product member of the ErbB family of tyrosine kinase receptors 67994
gene_regulation Th2 cytokine interleukin (IL)-13 causes activation via indirect mechanism 625656
gene_regulation Th2 cytokine interleukin (IL)-13 causes activation via indirect mechanism 628342
gene_transcript 2kb mRNA transcript 67994