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Gene: GRB2 (growth factor receptor bound protein 2) Homo sapiens
Symbol: GRB2
Name: growth factor receptor bound protein 2
Description: Exhibits several functions, including SH3 domain binding activity; insulin receptor substrate binding activity; and signaling receptor binding activity. Involved in several processes, including cellular response to ionizing radiation; insulin receptor signaling pathway; and signal transduction in response to DNA damage. Localizes to the Grb2-EGFR complex; endosome; and nucleus. Implicated in breast cancer; prostate adenocarcinoma; and prostate cancer. Biomarker of endometrial carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: abundant SRC homology; adapter protein GRB2; ASH; EGFRBP-GRB2; epidermal growth factor receptor-binding protein GRB2; Grb3-3; growth factor receptor-bound protein 2; growth factor receptor-bound protein 3; HT027; MST084; MSTP084; NCKAP2; SH2/SH3 adapter GRB2
Mus musculus (house mouse) : Grb2 (growth factor receptor bound protein 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Grb2 (growth factor receptor bound protein 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Grb2 (growth factor receptor bound protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : GRB2 (growth factor receptor bound protein 2)
Canis lupus familiaris (dog) : GRB2 (growth factor receptor bound protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grb2 (growth factor receptor bound protein 2)
Sus scrofa (pig) : GRB2 (growth factor receptor bound protein 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1775,318,076 - 75,405,709 (-)Ensembl
GRCh381775,318,076 - 75,405,709 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371773,314,157 - 73,401,790 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361770,825,752 - 70,913,385 (-)NCBINCBI36hg18NCBI36
Build 341770,825,752 - 70,913,329NCBI
Celera1769,906,645 - 69,994,307 (-)NCBI
Cytogenetic Map17q25.1NCBI
HuRef1768,724,752 - 68,824,731 (-)NCBIHuRef
CHM1_11773,378,804 - 73,466,430 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on GRB2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732473
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.