Irs2 (insulin receptor substrate 2) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Irs2 (insulin receptor substrate 2) Rattus norvegicus
Analyze
Symbol: Irs2
Name: insulin receptor substrate 2
RGD ID: 69316
Description: Exhibits several functions, including 14-3-3 protein binding activity; insulin receptor binding activity; and phosphatidylinositol 3-kinase binding activity. Involved in cellular response to glucose stimulus and insulin receptor signaling pathway. Predicted to localize to cytosol; plasma membrane; and protein-containing complex. Biomarker of non-alcoholic fatty liver disease and osteoporosis. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human IRS2 (insulin receptor substrate 2); PARTICIPATES IN insulin signaling pathway; erythropoietin signaling pathway; insulin-like growth factor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 4PS; IRS-2; LOC207125; similar to aldolase; tyrosine kinase substrate
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21678,488,249 - 78,512,482 (+)NCBI
Rnor_6.0 Ensembl1683,824,430 - 83,848,684 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01683,824,515 - 83,848,569 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01683,287,185 - 83,311,239 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41683,379,987 - 83,404,220 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11683,367,312 - 83,368,308 (+)NCBI
Celera1676,286,571 - 76,310,806 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
AM-251  (ISO)
ammonium chloride  (EXP)
avobenzone  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
boron nitride  (ISO)
bromobenzene  (EXP)
butanal  (ISO)
cadmium atom  (EXP)
candesartan  (ISO)
carbon nanotube  (ISO)
chlorpromazine  (EXP)
cisplatin  (ISO)
clobetasol  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP)
D-glucose  (ISO)
dexamethasone  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
formaldehyde  (ISO)
fructose  (EXP)
furan  (EXP)
genistein  (ISO)
gingerol  (ISO)
glucose  (ISO)
hexadecanoic acid  (ISO)
indole-3-methanol  (EXP)
lead diacetate  (ISO)
leflunomide  (EXP)
lipopolysaccharide  (EXP)
lovastatin  (ISO)
LY294002  (ISO)
maneb  (ISO)
medroxyprogesterone acetate  (ISO)
melatonin  (ISO)
mercury dichloride  (EXP)
metformin  (EXP)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
myricetin  (EXP)
myrtenal  (EXP)
N(6)-butyryl-cAMP  (EXP)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
neomycin  (ISO)
nickel atom  (ISO)
oleic acid  (EXP)
ozone  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
perfluorononanoic acid  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phoxim  (EXP)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
rac-lactic acid  (ISO)
ranitidine  (EXP)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP)
rottlerin  (EXP)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (EXP,ISO)
XL147  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
1. Anderwald C, etal., Mol Endocrinol 2002 Jul;16(7):1612-28.
2. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
3. Bueno MP, etal., Fetal Diagn Ther. 2010;28(3):145-52. doi: 10.1159/000316932. Epub 2010 Aug 19.
4. Cullingford TE, etal., Biochim Biophys Acta. 2008 Jun;1783(6):1229-36. Epub 2008 Mar 25.
5. Duan C, etal., J Biol Chem. 2004 Oct 15;279(42):43684-91. Epub 2004 Aug 16.
6. Freude S, etal., FASEB J. 2009 Oct;23(10):3315-24. doi: 10.1096/fj.09-132043. Epub 2009 Jun 1.
7. Fukushima T, etal., Mol Cell Endocrinol. 2011 Sep 15;344(1-2):81-9. Epub 2011 Jul 1.
8. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. GOA data from the GO Consortium
10. Hennige AM, etal., J Clin Invest. 2003 Nov;112(10):1521-32.
11. Hirata AE, etal., Life Sci. 2003 Aug 1;73(11):1369-81.
12. Hookham MB, etal., FEBS J. 2013 Jul;280(14):3232-43. doi: 10.1111/febs.12305. Epub 2013 May 29.
13. Jiang Y and Steinle JJ, Can J Physiol Pharmacol. 2010 May;88(5):553-61.
14. Khamzina L, etal., Gastroenterology 2003 Aug;125(2):572-85.
15. Kumar M, etal., Protein Cell. 2012 Oct;3(10):726-38. doi: 10.1007/s13238-012-2055-0. Epub 2012 Oct 11.
16. Li B, etal., Endocrine. 2013 Feb;43(1):136-46. doi: 10.1007/s12020-012-9757-1. Epub 2012 Jul 22.
17. Lingohr MK, etal., J Biol Chem. 2006 Jun 9;281(23):15884-92. Epub 2006 Mar 30.
18. Mammarella S, etal., Hum Mol Genet. 2000 Oct 12;9(17):2517-21.
19. Matsunami T, etal., Metabolism. 2011 Jun;60(6):805-14. Epub 2010 Sep 16.
20. MGD data from the GO Consortium
21. Moloney AM, etal., Neurobiol Aging. 2010 Feb;31(2):224-43. doi: 10.1016/j.neurobiolaging.2008.04.002. Epub .
22. NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. Neukamm SS, etal., PLoS One. 2012;7(8):e43296. doi: 10.1371/journal.pone.0043296. Epub 2012 Aug 17.
24. Okazawa K, etal., Diabetes Res Clin Pract. 2005 Apr;68(1):39-48.
25. OMIM Disease Annotation Pipeline
26. Pedros I, etal., Biochim Biophys Acta. 2014 Sep;1842(9):1556-66. doi: 10.1016/j.bbadis.2014.05.025. Epub 2014 Jun 2.
27. Pipeline to import KEGG annotations from KEGG into RGD
28. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
29. Pipeline to import SMPDB annotations from SMPDB into RGD
30. Pirola L, etal., J Biol Chem 2003 May 2;278(18):15641-51. Epub 2003 Feb 18.
31. RGD automated data pipeline
32. RGD automated import pipeline for gene-chemical interactions
33. RGD comprehensive gene curation
34. Schubert M, etal., J Neurosci 2003 Aug 6;23(18):7084-92.
Additional References at PubMed
PMID:11120660   PMID:11375348   PMID:12488434   PMID:12850284   PMID:12960006   PMID:12970360   PMID:14733908   PMID:15048126   PMID:15572028   PMID:15692808   PMID:16037383   PMID:16814735  
PMID:16921752   PMID:16925984   PMID:17299086   PMID:17332155   PMID:17636024   PMID:17662267   PMID:17761790   PMID:17901049   PMID:17925406   PMID:17993726   PMID:18590691   PMID:19088829  
PMID:19103603   PMID:19509476   PMID:19523444   PMID:19690174   PMID:19703555   PMID:21411721   PMID:21700708   PMID:21940781   PMID:22340657   PMID:22808485   PMID:23775122   PMID:24734256  
PMID:25036495   PMID:25879670   PMID:26027876   PMID:26657864   PMID:26919700   PMID:28065675   PMID:32045698   PMID:32631952  


Genomics

Candidate Gene Status
Irs2 is a candidate Gene for QTL Arunc2
Irs2 is a candidate Gene for QTL Arunc1
Comparative Map Data
Irs2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21678,488,249 - 78,512,482 (+)NCBI
Rnor_6.0 Ensembl1683,824,430 - 83,848,684 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01683,824,515 - 83,848,569 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01683,287,185 - 83,311,239 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41683,379,987 - 83,404,220 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11683,367,312 - 83,368,308 (+)NCBI
Celera1676,286,571 - 76,310,806 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
IRS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl13109,752,695 - 109,786,583 (-)EnsemblGRCh38hg38GRCh38
GRCh3813109,752,695 - 109,786,583 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3713110,405,042 - 110,438,930 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh3713110,406,184 - 110,438,914 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3613109,204,185 - 109,236,915 (-)NCBINCBI36hg18NCBI36
Build 3413109,204,186 - 109,236,915NCBI
Celera1391,250,464 - 91,283,200 (-)NCBI
Cytogenetic Map13q34NCBI
HuRef1391,005,522 - 91,037,072 (-)NCBIHuRef
CHM1_113110,375,378 - 110,407,600 (-)NCBICHM1_1
Irs2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39811,034,681 - 11,058,929 (-)NCBIGRCm39mm39
GRCm38810,984,681 - 11,008,929 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl810,984,681 - 11,008,458 (-)EnsemblGRCm38mm10GRCm38
MGSCv37810,986,961 - 11,008,430 (-)NCBIGRCm37mm9NCBIm37
MGSCv36810,986,933 - 11,008,402 (-)NCBImm8
Celera811,160,160 - 11,181,560 (-)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map85.35NCBI
Irs2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554042,531,484 - 2,555,689 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554042,531,484 - 2,555,383 (+)NCBIChiLan1.0ChiLan1.0
IRS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.113110,013,214 - 110,044,465 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01390,886,095 - 90,917,724 (-)NCBIMhudiblu_PPA_v0panPan3
IRS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2258,223,387 - 58,227,535 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12258,197,016 - 58,229,026 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Irs2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364722,772,187 - 2,796,398 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IRS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1176,626,179 - 76,653,881 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11176,626,158 - 76,654,639 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
IRS2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1388,045,439 - 88,076,468 (-)NCBI
Irs2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247932,615,092 - 2,636,835 (+)NCBI

Position Markers
D16Wox21  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01683,847,468 - 83,847,637NCBIRnor6.0
Rnor_5.01683,310,138 - 83,310,307UniSTSRnor5.0
RGSC_v3.41683,403,119 - 83,403,288UniSTSRGSC3.4
Celera1676,309,705 - 76,309,874UniSTS
Cytogenetic Map16q12.5UniSTS
PMC152262P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01683,827,168 - 83,827,285NCBIRnor6.0
Rnor_5.01683,289,838 - 83,289,955UniSTSRnor5.0
RGSC_v3.41683,382,640 - 83,382,757UniSTSRGSC3.4
Celera1676,289,224 - 76,289,341UniSTS
Cytogenetic Map16q12.5UniSTS
UniSTS:496713  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01683,825,042 - 83,825,437NCBIRnor6.0
Rnor_5.01683,287,712 - 83,288,107UniSTSRnor5.0
RGSC_v3.41683,380,514 - 83,380,909UniSTSRGSC3.4
Celera1676,287,098 - 76,287,493UniSTS
Cytogenetic Map16q12.5UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)16109005486162972Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163900002184000021Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)164151271086512710Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)164151271086512710Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164655818890668790Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165781635790668790Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165781635790668790Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165781635790668790Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165928577589248943Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:308
Count of miRNA genes:192
Interacting mature miRNAs:235
Transcripts:ENSRNOT00000032918
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 26 36 20 11 20 74 33 30 11
Low 1 17 21 21 8 21 8 11 2 11 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000032918   ⟹   ENSRNOP00000036862
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1683,824,430 - 83,848,684 (+)Ensembl
RefSeq Acc Id: NM_001168633   ⟹   NP_001162104
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21678,488,249 - 78,512,482 (+)NCBI
Rnor_6.01683,824,515 - 83,848,569 (+)NCBI
Rnor_5.01683,287,185 - 83,311,239 (+)NCBI
RGSC_v3.41683,379,987 - 83,404,220 (+)RGD
Celera1676,286,571 - 76,310,806 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001162104 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB49893 (Get FASTA)   NCBI Sequence Viewer  
  AAC05512 (Get FASTA)   NCBI Sequence Viewer  
  AAC33346 (Get FASTA)   NCBI Sequence Viewer  
  AAC36726 (Get FASTA)   NCBI Sequence Viewer  
  EDM08814 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001162104   ⟸   NM_001168633
- UniProtKB: F1MAL5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000036862   ⟸   ENSRNOT00000032918
Protein Domains
IRS-type PTB   PH

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
16 83288578 83288579 C T snv BUF/MNa (KyushuU)
16 83288694 83288695 A C snv FHH/EurMcwi (MCW), SR/JrHsd (MCW)


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
16 83826024 83826025 A C snv SR/JrHsd (MCW)


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
16 83380579 83380580 T G snv SR/JrHsd (MCW), FHH/EurMcwi (MCW), SS/JrHsdMcwi (MCW)
16 83381496 83381497 A C snv FHH/EurMcwi (MCW), SR/JrHsd (MCW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69316 AgrOrtholog
Ensembl Genes ENSRNOG00000023509 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000036862 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000032918 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
InterPro Insln_rcpt_S1 UniProtKB/TrEMBL
  IRS UniProtKB/TrEMBL
  PH_like_dom UniProtKB/TrEMBL
  Pleckstrin_homology UniProtKB/TrEMBL
KEGG Report rno:29376 UniProtKB/TrEMBL
NCBI Gene 29376 ENTREZGENE
PANTHER PTHR10614 UniProtKB/TrEMBL
Pfam IRS UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
PhenoGen Irs2 PhenoGen
PRINTS INSULINRSI UniProtKB/TrEMBL
PROSITE IRS_PTB UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
SMART PTBI UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
UniProt F1MAL5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-04-12 Irs2  insulin receptor substrate 2  LOC207125  similar to aldolase  Data Merged 737654 PROVISIONAL
2010-05-06 LOC207125  similar to aldolase  LOC207125  unknown protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-28 LOC207125        Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Irs2  insulin receptor substrate 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference