(+)-catechin multiple interactions ISO IRS2 (Homo sapiens) 6480464 Catechin inhibits the reaction [Glucose results in decreased expression of IRS2 protein modified form] and Catechin inhibits the reaction [Glucose results in decreased expression of IRS2 protein] CTD PMID:24262486 (-)-epigallocatechin 3-gallate multiple interactions ISO IRS2 (Homo sapiens) 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of IRS2 mRNA CTD PMID:22079256 (1->4)-beta-D-glucan multiple interactions ISO Irs2 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of IRS2 mRNA CTD PMID:36331819 17beta-estradiol multiple interactions ISO IRS2 (Homo sapiens) 6480464 [Estradiol co-treated with Norethindrone Acetate] results in increased expression of IRS2 mRNA more ... CTD PMID:15949379 more ... 17beta-estradiol affects expression EXP 6480464 Estradiol affects the expression of IRS2 mRNA CTD PMID:32145629 17beta-estradiol decreases expression ISO IRS2 (Homo sapiens) 6480464 Estradiol results in decreased expression of IRS2 mRNA CTD PMID:19167446 17beta-estradiol increases phosphorylation ISO IRS2 (Homo sapiens) 6480464 Estradiol results in increased phosphorylation of IRS2 protein CTD PMID:15949379 17beta-estradiol increases expression ISO IRS2 (Homo sapiens) 6480464 Estradiol results in increased expression of IRS2 mRNA and Estradiol results in increased expression of IRS2 protein CTD PMID:15949379 17beta-hydroxy-5alpha-androstan-3-one increases expression ISO IRS2 (Homo sapiens) 6480464 Dihydrotestosterone results in increased expression of IRS2 mRNA CTD PMID:29581250 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Irs2 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 2,2',4,4'-Tetrabromodiphenyl ether decreases expression ISO IRS2 (Homo sapiens) 6480464 2 more ... CTD PMID:31675489 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Irs2 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:16054899 and PMID:28433925 2,3,7,8-tetrachlorodibenzodioxine decreases phosphorylation EXP 6480464 Tetrachlorodibenzodioxin results in decreased phosphorylation of IRS2 protein CTD PMID:23639626 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Irs2 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of IRS2 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of IRS2 mRNA CTD PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of IRS2 mRNA CTD PMID:22298810 2,4-dinitrotoluene affects expression EXP 6480464 2 and 4-dinitrotoluene affects the expression of IRS2 mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression EXP 6480464 2 and 6-dinitrotoluene affects the expression of IRS2 mRNA CTD PMID:21346803 2-hydroxypropanoic acid increases expression ISO IRS2 (Homo sapiens) 6480464 Lactic Acid results in increased expression of IRS2 mRNA CTD PMID:30851411 2-methylcholine affects expression ISO IRS2 (Homo sapiens) 6480464 beta-methylcholine affects the expression of IRS2 mRNA CTD PMID:21179406 3,3',4,4',5-pentachlorobiphenyl affects expression ISO Irs2 (Mus musculus) 6480464 3 more ... CTD PMID:37080397 3,3',5,5'-tetrabromobisphenol A increases expression ISO IRS2 (Homo sapiens) 6480464 tetrabromobisphenol A results in increased expression of IRS2 protein CTD PMID:31675489 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO Irs2 (Mus musculus) 6480464 [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IRS2 mRNA more ... CTD PMID:16054899 4,4'-sulfonyldiphenol increases methylation ISO Irs2 (Mus musculus) 6480464 bisphenol S results in increased methylation of IRS2 exon CTD PMID:33297965 4,4'-sulfonyldiphenol affects methylation ISO Irs2 (Mus musculus) 6480464 bisphenol S affects the methylation of IRS2 gene CTD PMID:31683443 4-hydroxy-TEMPO multiple interactions ISO Irs2 (Mus musculus) 6480464 tempol inhibits the reaction [Benzene results in decreased phosphorylation of IRS2 protein] CTD PMID:30346588 4-hydroxyphenyl retinamide increases expression ISO Irs2 (Mus musculus) 6480464 Fenretinide results in increased expression of IRS2 mRNA CTD PMID:28973697 5-aza-2'-deoxycytidine increases expression ISO IRS2 (Homo sapiens) 6480464 Decitabine results in increased expression of IRS2 mRNA CTD PMID:16367923 acrylamide increases expression ISO IRS2 (Homo sapiens) 6480464 Acrylamide results in increased expression of IRS2 mRNA CTD PMID:32763439 aflatoxin B1 decreases methylation ISO IRS2 (Homo sapiens) 6480464 Aflatoxin B1 results in decreased methylation of IRS2 gene CTD PMID:27153756 aldehydo-D-glucose increases phosphorylation ISO IRS2 (Homo sapiens) 6480464 Glucose results in increased phosphorylation of IRS2 protein CTD PMID:10430617 aldehydo-D-glucose decreases expression ISO IRS2 (Homo sapiens) 6480464 Glucose results in decreased expression of IRS2 protein and Glucose results in decreased expression of IRS2 protein modified form CTD PMID:24262486 aldehydo-D-glucose multiple interactions ISO IRS2 (Homo sapiens) 6480464 Catechin inhibits the reaction [Glucose results in decreased expression of IRS2 protein modified form] more ... CTD PMID:24262486 aldehydo-D-glucose increases abundance ISO Irs2 (Mus musculus) 6480464 IRS2 gene mutant form results in increased abundance of Glucose CTD PMID:20028942 all-trans-retinoic acid increases expression ISO IRS2 (Homo sapiens) 6480464 Tretinoin results in increased expression of IRS2 mRNA CTD PMID:16249480 and PMID:23724009 AM-251 multiple interactions ISO Irs2 (Mus musculus) 6480464 AM 251 inhibits the reaction [Dietary Fats results in decreased phosphorylation of IRS2 protein] CTD PMID:26847930 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of IRS2 mRNA CTD PMID:16483693 aristolochic acid A decreases expression ISO IRS2 (Homo sapiens) 6480464 aristolochic acid I results in decreased expression of IRS2 mRNA and aristolochic acid I results in decreased expression of IRS2 protein CTD PMID:33212167 arsane multiple interactions ISO IRS2 (Homo sapiens) 6480464 [Palmitic Acid co-treated with Arsenic] results in increased expression of IRS2 mRNA CTD PMID:33736254 arsane increases expression ISO IRS2 (Homo sapiens) 6480464 Arsenic results in increased expression of IRS2 mRNA CTD PMID:33736254 arsenic atom multiple interactions ISO IRS2 (Homo sapiens) 6480464 [Palmitic Acid co-treated with Arsenic] results in increased expression of IRS2 mRNA CTD PMID:33736254 arsenic atom increases expression ISO IRS2 (Homo sapiens) 6480464 Arsenic results in increased expression of IRS2 mRNA CTD PMID:33736254 avobenzone increases expression ISO IRS2 (Homo sapiens) 6480464 avobenzone results in increased expression of IRS2 mRNA CTD PMID:31016361 benzene multiple interactions ISO Irs2 (Mus musculus) 6480464 tempol inhibits the reaction [Benzene results in decreased phosphorylation of IRS2 protein] CTD PMID:30346588 benzene decreases phosphorylation ISO Irs2 (Mus musculus) 6480464 Benzene results in decreased phosphorylation of IRS2 protein CTD PMID:30346588 benzo[a]pyrene increases expression ISO IRS2 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased expression of IRS2 mRNA CTD PMID:22316170 benzo[a]pyrene increases methylation ISO IRS2 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased methylation of IRS2 exon and Benzo(a)pyrene results in increased methylation of IRS2 promoter CTD PMID:27901495 beta-naphthoflavone multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of IRS2 mRNA CTD PMID:18164116 bis(2-ethylhexyl) phthalate decreases expression EXP 6480464 Diethylhexyl Phthalate results in decreased expression of IRS2 protein CTD PMID:25280772 bis(2-ethylhexyl) phthalate multiple interactions ISO Irs2 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of IRS2 mRNA and bisphenol A results in decreased expression of IRS2 protein CTD PMID:22101236 and PMID:32145629 bisphenol A increases expression ISO Irs2 (Mus musculus) 6480464 bisphenol A results in increased expression of IRS2 mRNA CTD PMID:32156529 bisphenol A decreases methylation ISO IRS2 (Homo sapiens) 6480464 bisphenol A results in decreased methylation of IRS2 gene CTD PMID:31601247 bisphenol A multiple interactions ISO IRS2 (Homo sapiens) 6480464 [bisphenol A co-treated with Fulvestrant] results in increased methylation of IRS2 gene CTD PMID:31601247 bisphenol A increases expression ISO IRS2 (Homo sapiens) 6480464 bisphenol A results in increased expression of IRS2 mRNA CTD PMID:29721103 bisphenol A decreases expression ISO IRS2 (Homo sapiens) 6480464 bisphenol A results in decreased expression of IRS2 mRNA and bisphenol A results in decreased expression of IRS2 protein CTD PMID:29718440 and PMID:31675489 bisphenol A multiple interactions ISO Irs2 (Mus musculus) 6480464 [Streptozocin co-treated with bisphenol A] results in decreased expression of IRS2 mRNA more ... CTD PMID:28433925 and PMID:29935216 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of IRS2 mRNA CTD PMID:25181051 bisphenol A decreases expression ISO Irs2 (Mus musculus) 6480464 bisphenol A results in decreased expression of IRS2 mRNA CTD PMID:26779933 and PMID:38074096 boron nitride increases expression ISO IRS2 (Homo sapiens) 6480464 boron nitride results in increased expression of IRS2 mRNA CTD PMID:30644070 bromobenzene increases expression EXP 6480464 bromobenzene results in increased expression of IRS2 mRNA CTD PMID:32479839 butanal decreases expression ISO IRS2 (Homo sapiens) 6480464 butyraldehyde results in decreased expression of IRS2 mRNA CTD PMID:26079696 cadmium atom multiple interactions EXP 6480464 [Streptozocin co-treated with Cadmium] results in decreased expression of IRS2 protein and myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in decreased expression of IRS2 protein] CTD PMID:24923654 cadmium atom multiple interactions ISO IRS2 (Homo sapiens) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of IRS2 mRNA CTD PMID:35301059 cadmium dichloride multiple interactions ISO IRS2 (Homo sapiens) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of IRS2 mRNA CTD PMID:35301059 candesartan multiple interactions ISO Irs2 (Mus musculus) 6480464 [GCG protein co-treated with candesartan] inhibits the reaction [Palmitic Acid results in decreased phosphorylation of IRS2 protein] and candesartan inhibits the reaction [Palmitic Acid results in decreased phosphorylation of IRS2 protein] CTD PMID:21255808 carbon nanotube decreases expression ISO Irs2 (Mus musculus) 6480464 Nanotubes and Carbon results in decreased expression of IRS2 mRNA CTD PMID:25554681 and PMID:25620056 chlorpromazine multiple interactions EXP 6480464 Chlorpromazine results in decreased expression of and results in decreased phosphorylation of IRS2 protein and Chlorpromazine results in decreased expression of and results in increased degradation of IRS2 protein CTD PMID:17512020 and PMID:18308779 chlorpyrifos decreases expression ISO Irs2 (Mus musculus) 6480464 Chlorpyrifos results in decreased expression of IRS2 mRNA CTD PMID:37019170 choline multiple interactions ISO Irs2 (Mus musculus) 6480464 [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of IRS2 mRNA CTD PMID:33549593 cisplatin decreases expression ISO IRS2 (Homo sapiens) 6480464 Cisplatin results in decreased expression of IRS2 mRNA CTD PMID:27392435 clobetasol decreases expression ISO Irs2 (Mus musculus) 6480464 Clobetasol results in decreased expression of IRS2 mRNA CTD PMID:27462272 cocaine increases expression EXP 6480464 Cocaine results in increased expression of IRS2 mRNA CTD PMID:27899881 copper atom multiple interactions ISO IRS2 (Homo sapiens) 6480464 [NSC 689534 binds to Copper] which results in increased expression of IRS2 mRNA CTD PMID:20971185 copper(0) multiple interactions ISO IRS2 (Homo sapiens) 6480464 [NSC 689534 binds to Copper] which results in increased expression of IRS2 mRNA CTD PMID:20971185 copper(II) chloride increases expression ISO IRS2 (Homo sapiens) 6480464 cupric chloride results in increased expression of IRS2 mRNA CTD PMID:17211630 coumarin affects phosphorylation ISO IRS2 (Homo sapiens) 6480464 coumarin affects the phosphorylation of IRS2 protein CTD PMID:35688186 coumestrol decreases expression ISO IRS2 (Homo sapiens) 6480464 Coumestrol results in decreased expression of IRS2 mRNA CTD PMID:19167446 coumestrol multiple interactions ISO IRS2 (Homo sapiens) 6480464 [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of IRS2 mRNA CTD PMID:19167446 crocidolite asbestos increases expression ISO IRS2 (Homo sapiens) 6480464 Asbestos and Crocidolite results in increased expression of IRS2 mRNA CTD PMID:18687144 curcumin affects phosphorylation ISO Irs2 (Mus musculus) 6480464 Curcumin affects the phosphorylation of IRS2 protein CTD PMID:27208389 cyanocob(III)alamin multiple interactions ISO Irs2 (Mus musculus) 6480464 [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of IRS2 mRNA CTD PMID:33549593 cyclosporin A increases expression ISO IRS2 (Homo sapiens) 6480464 Cyclosporine results in increased expression of IRS2 mRNA CTD PMID:20106945 cyclosporin A decreases expression ISO IRS2 (Homo sapiens) 6480464 Cyclosporine results in decreased expression of IRS2 mRNA CTD PMID:27989131 cypermethrin decreases expression EXP 6480464 cypermethrin results in decreased expression of IRS2 mRNA CTD PMID:22528246 D-glucose increases phosphorylation ISO IRS2 (Homo sapiens) 6480464 Glucose results in increased phosphorylation of IRS2 protein CTD PMID:10430617 D-glucose decreases expression ISO IRS2 (Homo sapiens) 6480464 Glucose results in decreased expression of IRS2 protein and Glucose results in decreased expression of IRS2 protein modified form CTD PMID:24262486 D-glucose multiple interactions ISO IRS2 (Homo sapiens) 6480464 Catechin inhibits the reaction [Glucose results in decreased expression of IRS2 protein modified form] more ... CTD PMID:24262486 D-glucose increases abundance ISO Irs2 (Mus musculus) 6480464 IRS2 gene mutant form results in increased abundance of Glucose CTD PMID:20028942 decabromodiphenyl ether decreases expression ISO IRS2 (Homo sapiens) 6480464 decabromobiphenyl ether results in decreased expression of IRS2 protein CTD PMID:31675489 dexamethasone multiple interactions ISO Irs2 (Mus musculus) 6480464 [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IRS2 mRNA more ... CTD PMID:16054899 dexamethasone increases expression ISO Irs2 (Mus musculus) 6480464 Dexamethasone results in increased expression of IRS2 mRNA CTD PMID:22733784 diazinon increases methylation ISO IRS2 (Homo sapiens) 6480464 Diazinon results in increased methylation of IRS2 gene CTD PMID:22964155 dibutyl phthalate increases expression ISO Irs2 (Mus musculus) 6480464 Dibutyl Phthalate results in increased expression of IRS2 mRNA CTD PMID:17361019 and PMID:21266533 dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of IRS2 mRNA CTD PMID:17379624 dinophysistoxin 1 increases expression ISO IRS2 (Homo sapiens) 6480464 dinophysistoxin 1 results in increased expression of IRS2 mRNA CTD PMID:28939011 dioxygen multiple interactions ISO Irs2 (Mus musculus) 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of IRS2 mRNA CTD PMID:30529165 dorsomorphin multiple interactions ISO IRS2 (Homo sapiens) 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS2 mRNA CTD PMID:27188386 doxorubicin affects expression ISO IRS2 (Homo sapiens) 6480464 Doxorubicin affects the expression of IRS2 mRNA CTD PMID:25529476 endosulfan increases expression EXP 6480464 Endosulfan results in increased expression of IRS2 mRNA CTD PMID:29391264 and PMID:31464424 Enterolactone multiple interactions ISO IRS2 (Homo sapiens) 6480464 [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of IRS2 mRNA CTD PMID:19167446 enzyme inhibitor multiple interactions ISO IRS2 (Homo sapiens) 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of IRS2 protein CTD PMID:23301498 epoxiconazole increases expression ISO Irs2 (Mus musculus) 6480464 epoxiconazole results in increased expression of IRS2 mRNA CTD PMID:35436446 ethanol multiple interactions EXP 6480464 [Dietary Fats co-treated with Ethanol] results in increased expression of IRS2 mRNA CTD PMID:24275070 ethanol affects expression EXP 6480464 Ethanol affects the expression of IRS2 mRNA CTD PMID:31039417 ethanol affects expression ISO Irs2 (Mus musculus) 6480464 Ethanol affects the expression of IRS2 mRNA CTD PMID:30319688 ethyl methanesulfonate increases expression ISO IRS2 (Homo sapiens) 6480464 Ethyl Methanesulfonate results in increased expression of IRS2 mRNA CTD PMID:23649840 etoposide affects response to substance ISO IRS2 (Homo sapiens) 6480464 IRS2 protein affects the susceptibility to Etoposide CTD PMID:16217747 flavonoids decreases expression EXP 6480464 Flavonoids results in decreased expression of IRS2 mRNA CTD PMID:18035473 flutamide decreases expression EXP 6480464 Flutamide results in decreased expression of IRS2 mRNA CTD PMID:24136188 folic acid multiple interactions ISO Irs2 (Mus musculus) 6480464 [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of IRS2 mRNA CTD PMID:33549593 formaldehyde increases expression ISO IRS2 (Homo sapiens) 6480464 Formaldehyde results in increased expression of IRS2 mRNA CTD PMID:23649840 FR900359 affects phosphorylation ISO IRS2 (Homo sapiens) 6480464 FR900359 affects the phosphorylation of IRS2 protein CTD PMID:37730182 fructose decreases expression EXP 6480464 Fructose results in decreased expression of IRS2 mRNA and Fructose results in decreased expression of IRS2 protein CTD PMID:19008412 more ... fructose multiple interactions EXP 6480464 NOS3 protein inhibits the reaction [Fructose results in decreased expression of IRS2 protein] and resveratrol inhibits the reaction [Fructose results in decreased expression of IRS2 mRNA] CTD PMID:19008412 and PMID:26488877 fulvestrant multiple interactions ISO IRS2 (Homo sapiens) 6480464 [bisphenol A co-treated with Fulvestrant] results in increased methylation of IRS2 gene CTD PMID:31601247 furan decreases expression EXP 6480464 furan results in decreased expression of IRS2 mRNA CTD PMID:26194646 Ganoderic acid A multiple interactions ISO Irs2 (Mus musculus) 6480464 [Dietary Fats co-treated with ganoderic acid A] affects the expression of IRS2 mRNA CTD PMID:29852127 genistein decreases expression ISO IRS2 (Homo sapiens) 6480464 Genistein results in decreased expression of IRS2 mRNA CTD PMID:19371625 genistein increases expression ISO IRS2 (Homo sapiens) 6480464 Genistein results in increased expression of IRS2 mRNA CTD PMID:22228119 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of IRS2 mRNA CTD PMID:33387578 gingerol multiple interactions ISO Irs2 (Mus musculus) 6480464 gingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS2 mRNA] and gingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS2 protein] CTD PMID:22285432 glucose increases phosphorylation ISO IRS2 (Homo sapiens) 6480464 Glucose results in increased phosphorylation of IRS2 protein CTD PMID:10430617 glucose decreases expression ISO IRS2 (Homo sapiens) 6480464 Glucose results in decreased expression of IRS2 protein and Glucose results in decreased expression of IRS2 protein modified form CTD PMID:24262486 glucose multiple interactions ISO IRS2 (Homo sapiens) 6480464 Catechin inhibits the reaction [Glucose results in decreased expression of IRS2 protein modified form] more ... CTD PMID:24262486 glucose increases abundance ISO Irs2 (Mus musculus) 6480464 IRS2 gene mutant form results in increased abundance of Glucose CTD PMID:20028942 glyburide multiple interactions EXP 6480464 Glyburide inhibits the reaction [Streptozocin results in decreased expression of IRS2 protein] CTD PMID:33724628 glycine betaine multiple interactions ISO Irs2 (Mus musculus) 6480464 [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of IRS2 mRNA CTD PMID:33549593 glyphosate increases expression ISO Irs2 (Mus musculus) 6480464 Glyphosate results in increased expression of IRS2 mRNA CTD PMID:35897073 hexadecanoic acid multiple interactions ISO Irs2 (Mus musculus) 6480464 [GCG protein co-treated with candesartan] inhibits the reaction [Palmitic Acid results in decreased phosphorylation of IRS2 protein] more ... CTD PMID:21255808 hexadecanoic acid multiple interactions ISO IRS2 (Homo sapiens) 6480464 [Palmitic Acid co-treated with Arsenic] results in increased expression of IRS2 mRNA CTD PMID:33736254 hexadecanoic acid decreases phosphorylation ISO Irs2 (Mus musculus) 6480464 Palmitic Acid results in decreased phosphorylation of IRS2 protein CTD PMID:21255808 indole-3-methanol multiple interactions EXP 6480464 [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of IRS2 mRNA CTD PMID:22129741 inulin multiple interactions ISO Irs2 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of IRS2 mRNA CTD PMID:36331819 iron dichloride decreases expression ISO IRS2 (Homo sapiens) 6480464 ferrous chloride results in decreased expression of IRS2 mRNA CTD PMID:35984750 L-methionine multiple interactions ISO Irs2 (Mus musculus) 6480464 [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of IRS2 mRNA CTD PMID:33549593 lead diacetate decreases expression ISO Irs2 (Mus musculus) 6480464 lead acetate results in decreased expression of IRS2 mRNA CTD PMID:21829687 leflunomide increases expression EXP 6480464 leflunomide results in increased expression of IRS2 mRNA CTD PMID:24136188 lipopolysaccharide increases expression EXP 6480464 Lipopolysaccharides results in increased expression of IRS2 mRNA CTD PMID:16415329 lipopolysaccharide multiple interactions EXP 6480464 Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of IRS2 mRNA] CTD PMID:16415329 lovastatin multiple interactions ISO Irs2 (Mus musculus) 6480464 [Dietary Fats co-treated with Lovastatin] affects the expression of IRS2 mRNA CTD PMID:29852127 LY294002 multiple interactions ISO IRS2 (Homo sapiens) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [IAPP protein promotes the reaction [rosiglitazone results in increased expression of IRS2 protein]] CTD PMID:16204373 maneb multiple interactions ISO Irs2 (Mus musculus) 6480464 [Maneb co-treated with Paraquat] results in decreased expression of IRS2 mRNA more ... CTD PMID:23963992 and PMID:36117858 medroxyprogesterone acetate increases expression ISO IRS2 (Homo sapiens) 6480464 Medroxyprogesterone Acetate results in increased expression of IRS2 mRNA CTD PMID:20843944 melatonin multiple interactions ISO Irs2 (Mus musculus) 6480464 Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of IRS2 mRNA] CTD PMID:23963992 mercury dichloride increases expression EXP 6480464 Mercuric Chloride results in increased expression of IRS2 mRNA CTD PMID:16507785 metformin decreases expression EXP 6480464 Metformin results in decreased expression of IRS2 mRNA CTD PMID:31324951 metformin multiple interactions ISO IRS2 (Homo sapiens) 6480464 Metformin inhibits the reaction [INS protein results in decreased expression of IRS2 protein] CTD PMID:36764371 methapyrilene decreases expression EXP 6480464 Methapyrilene results in decreased expression of IRS2 mRNA CTD PMID:30467583 methyl methanesulfonate increases expression ISO IRS2 (Homo sapiens) 6480464 Methyl Methanesulfonate results in increased expression of IRS2 mRNA CTD PMID:23649840 methylisothiazolinone increases expression ISO IRS2 (Homo sapiens) 6480464 2-methyl-4-isothiazolin-3-one results in increased expression of IRS2 mRNA CTD PMID:31629900 methylmercury chloride affects expression EXP 6480464 methylmercuric chloride affects the expression of IRS2 mRNA CTD PMID:20864626 methylmercury chloride increases expression ISO IRS2 (Homo sapiens) 6480464 methylmercuric chloride results in increased expression of IRS2 mRNA CTD PMID:28001369 microcystin-LR decreases expression ISO Irs2 (Mus musculus) 6480464 cyanoginosin LR results in decreased expression of IRS2 mRNA and cyanoginosin LR results in decreased expression of IRS2 protein CTD PMID:29777831 microcystin-LR decreases phosphorylation ISO Irs2 (Mus musculus) 6480464 cyanoginosin LR results in decreased phosphorylation of IRS2 protein CTD PMID:29777831 mono(2-ethylhexyl) phthalate increases expression ISO Irs2 (Mus musculus) 6480464 mono-(2-ethylhexyl)phthalate results in increased expression of IRS2 mRNA CTD PMID:25543134 monosodium L-glutamate decreases expression ISO Irs2 (Mus musculus) 6480464 Sodium Glutamate results in decreased expression of IRS2 mRNA CTD PMID:18048028 monosodium L-glutamate multiple interactions ISO Irs2 (Mus musculus) 6480464 2-ethoxy-3-(4-(2-(4-trifluoromethanesulfonyloxyphenyl)ethoxy)phenyl)propionic acid inhibits the reaction [Sodium Glutamate results in decreased expression of IRS2 mRNA] CTD PMID:18048028 myricetin multiple interactions EXP 6480464 myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in decreased expression of IRS2 protein] CTD PMID:24923654 myrtenal multiple interactions EXP 6480464 myrtenal inhibits the reaction [Streptozocin results in decreased expression of IRS2 protein] CTD PMID:27417257 N(6)-butyryl-cAMP multiple interactions EXP 6480464 CREM protein inhibits the reaction [monobutyryl cyclic AMP results in increased expression of IRS2 mRNA] CTD PMID:25381014 N(6)-butyryl-cAMP increases expression EXP 6480464 monobutyryl cyclic AMP results in increased expression of IRS2 mRNA CTD PMID:25381014 N-acetyl-L-cysteine multiple interactions EXP 6480464 [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of IRS2 mRNA CTD PMID:22129741 N-methyl-4-phenylpyridinium multiple interactions ISO IRS2 (Homo sapiens) 6480464 INS protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of IRS2 protein] CTD PMID:26364587 N-methyl-4-phenylpyridinium decreases expression ISO IRS2 (Homo sapiens) 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of IRS2 protein CTD PMID:26364587 N-nitrosodiethylamine affects expression EXP 6480464 Diethylnitrosamine affects the expression of IRS2 mRNA CTD PMID:20387270 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of IRS2 mRNA and [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of IRS2 mRNA CTD PMID:18164116 and PMID:22129741 N-nitrosomorpholine increases expression EXP 6480464 N-nitrosomorpholine results in increased expression of IRS2 protein CTD PMID:21411721 N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine multiple interactions EXP 6480464 Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of IRS2 mRNA] CTD PMID:16415329 neomycin increases expression ISO Irs2 (Mus musculus) 6480464 Neomycin results in increased expression of IRS2 mRNA CTD PMID:30626089 nickel atom decreases expression ISO IRS2 (Homo sapiens) 6480464 Nickel results in decreased expression of IRS2 mRNA CTD PMID:24768652 and PMID:25583101 nicotinamide multiple interactions EXP 6480464 [Streptozocin co-treated with Niacinamide] results in decreased expression of IRS2 protein more ... CTD PMID:37566541 oleic acid multiple interactions EXP 6480464 IRS2 inhibits the reaction [Oleic Acid results in increased cleavage of CASP9 protein] and Oleic Acid inhibits the reaction [IRS2 results in increased phosphorylation of and results in increased activity of AKT1 protein] CTD PMID:14604813 ozone increases expression EXP 6480464 Ozone results in increased expression of IRS2 mRNA CTD PMID:25838073 ozone multiple interactions EXP 6480464 [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of IRS2 mRNA CTD PMID:36412511 and PMID:37088303 ozone multiple interactions ISO IRS2 (Homo sapiens) 6480464 [Air Pollutants results in increased abundance of Ozone] which affects the expression of IRS2 mRNA CTD PMID:35430440 ozone decreases expression EXP 6480464 Ozone results in decreased expression of IRS2 mRNA CTD PMID:33524448 paracetamol increases expression ISO IRS2 (Homo sapiens) 6480464 Acetaminophen results in increased expression of IRS2 mRNA CTD PMID:21420995 and PMID:29067470 paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of IRS2 mRNA CTD PMID:33387578 paraquat multiple interactions ISO Irs2 (Mus musculus) 6480464 [Maneb co-treated with Paraquat] results in decreased expression of IRS2 mRNA more ... CTD PMID:23963992 and PMID:36117858 perfluorononanoic acid increases expression ISO IRS2 (Homo sapiens) 6480464 perfluoro-n-nonanoic acid results in increased expression of IRS2 mRNA CTD PMID:32588087 perfluorooctane-1-sulfonic acid multiple interactions ISO Irs2 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of IRS2 mRNA more ... CTD PMID:36331819 phenformin decreases expression EXP 6480464 Phenformin results in decreased expression of IRS2 mRNA CTD PMID:31324951 phenobarbital decreases expression ISO Irs2 (Mus musculus) 6480464 Phenobarbital results in decreased expression of IRS2 mRNA CTD PMID:19270015 more ... phoxim decreases expression EXP 6480464 phoxim results in decreased expression of IRS2 mRNA CTD PMID:30090575 pirinixic acid increases expression ISO Irs2 (Mus musculus) 6480464 pirinixic acid results in increased expression of IRS2 mRNA CTD PMID:18445702 piroxicam decreases expression ISO IRS2 (Homo sapiens) 6480464 Piroxicam results in decreased expression of IRS2 mRNA CTD PMID:21858171 potassium chromate multiple interactions ISO IRS2 (Homo sapiens) 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of IRS2 mRNA CTD PMID:22079256 potassium chromate increases expression ISO IRS2 (Homo sapiens) 6480464 potassium chromate(VI) results in increased expression of IRS2 mRNA CTD PMID:22079256 pregnenolone 16alpha-carbonitrile decreases expression ISO Irs2 (Mus musculus) 6480464 Pregnenolone Carbonitrile results in decreased expression of IRS2 mRNA CTD PMID:27413110 pregnenolone 16alpha-carbonitrile increases expression ISO Irs2 (Mus musculus) 6480464 Pregnenolone Carbonitrile results in increased expression of IRS2 mRNA CTD PMID:28903501 progesterone multiple interactions ISO IRS2 (Homo sapiens) 6480464 [Progesterone co-treated with Estradiol] results in increased expression of IRS2 mRNA more ... CTD PMID:15949379 and PMID:17404688 progesterone increases expression ISO IRS2 (Homo sapiens) 6480464 Progesterone results in increased expression of IRS2 mRNA and Progesterone results in increased expression of IRS2 protein CTD PMID:15949379 more ... progesterone increases phosphorylation ISO IRS2 (Homo sapiens) 6480464 Progesterone results in increased phosphorylation of IRS2 protein CTD PMID:15949379 quercetin multiple interactions EXP 6480464 Quercetin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of IRS2 protein] CTD PMID:37566541 rac-lactic acid increases expression ISO IRS2 (Homo sapiens) 6480464 Lactic Acid results in increased expression of IRS2 mRNA CTD PMID:30851411 ranitidine multiple interactions EXP 6480464 Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of IRS2 mRNA] CTD PMID:16415329 rebaudioside A multiple interactions ISO Irs2 (Mus musculus) 6480464 rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS2 mRNA] CTD PMID:25554529 resveratrol increases expression EXP 6480464 resveratrol results in increased expression of IRS2 mRNA CTD PMID:25238689 more ... resveratrol multiple interactions ISO Irs2 (Mus musculus) 6480464 resveratrol inhibits the reaction [IRS2 gene mutant form results in decreased expression of HMOX1 mRNA] more ... CTD PMID:20028942 and PMID:25808216 resveratrol multiple interactions ISO IRS2 (Homo sapiens) 6480464 resveratrol inhibits the reaction [IRS2 gene mutant form inhibits the reaction [INS protein results in increased expression of IRS2 protein]] more ... CTD PMID:25808216 resveratrol decreases expression ISO IRS2 (Homo sapiens) 6480464 resveratrol results in decreased expression of IRS2 mRNA CTD PMID:25667456 resveratrol multiple interactions EXP 6480464 resveratrol inhibits the reaction [Fructose results in decreased expression of IRS2 mRNA] and resveratrol inhibits the reaction [Streptozocin results in decreased expression of IRS2 mRNA] CTD PMID:26071184 and PMID:26488877 rotenone affects expression EXP 6480464 Rotenone affects the expression of IRS2 mRNA CTD PMID:28374803 rottlerin decreases expression EXP 6480464 rottlerin results in decreased expression of IRS2 protein CTD PMID:18308779 SB 431542 multiple interactions ISO IRS2 (Homo sapiens) 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS2 mRNA CTD PMID:27188386 serpentine asbestos increases expression ISO IRS2 (Homo sapiens) 6480464 Asbestos and Serpentine results in increased expression of IRS2 mRNA CTD PMID:29523930 silicon dioxide decreases expression ISO IRS2 (Homo sapiens) 6480464 Silicon Dioxide analog results in decreased expression of IRS2 mRNA CTD PMID:25895662 silicon dioxide increases expression ISO IRS2 (Homo sapiens) 6480464 Silicon Dioxide results in increased expression of IRS2 mRNA CTD PMID:25351596 silver atom increases expression ISO IRS2 (Homo sapiens) 6480464 Silver results in increased expression of IRS2 mRNA CTD PMID:26551752 silver(0) increases expression ISO IRS2 (Homo sapiens) 6480464 Silver results in increased expression of IRS2 mRNA CTD PMID:26551752 sodium arsenite multiple interactions ISO Irs2 (Mus musculus) 6480464 gingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS2 mRNA] and gingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS2 protein] CTD PMID:22285432 sodium arsenite decreases expression ISO IRS2 (Homo sapiens) 6480464 sodium arsenite results in decreased expression of IRS2 mRNA CTD PMID:37956786 sodium arsenite increases expression ISO Irs2 (Mus musculus) 6480464 sodium arsenite results in increased expression of IRS2 mRNA CTD PMID:36209798 sodium arsenite decreases expression ISO Irs2 (Mus musculus) 6480464 sodium arsenite results in decreased expression of IRS2 mRNA and sodium arsenite results in decreased expression of IRS2 protein CTD PMID:22285432 Soman increases expression EXP 6480464 Soman results in increased expression of IRS2 mRNA CTD PMID:19281266 steviol multiple interactions ISO Irs2 (Mus musculus) 6480464 steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS2 mRNA] CTD PMID:25554529 stevioside multiple interactions ISO Irs2 (Mus musculus) 6480464 stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS2 mRNA] CTD PMID:25554529 streptozocin multiple interactions EXP 6480464 [Streptozocin co-treated with Cadmium] results in decreased expression of IRS2 protein more ... CTD PMID:24923654 more ... streptozocin multiple interactions ISO Irs2 (Mus musculus) 6480464 [Streptozocin co-treated with bisphenol A] results in decreased expression of IRS2 mRNA and [Streptozocin co-treated with octylphenol] results in decreased expression of IRS2 mRNA CTD PMID:29935216 streptozocin decreases expression EXP 6480464 Streptozocin results in decreased expression of IRS2 mRNA and Streptozocin results in decreased expression of IRS2 protein CTD PMID:26071184 more ... sulfasalazine decreases expression ISO Irs2 (Mus musculus) 6480464 Sulfasalazine results in decreased expression of IRS2 mRNA CTD PMID:31830553 sulforaphane decreases expression ISO Irs2 (Mus musculus) 6480464 sulforaphane results in decreased expression of IRS2 mRNA CTD PMID:30529165 sunitinib increases expression ISO IRS2 (Homo sapiens) 6480464 Sunitinib results in increased expression of IRS2 mRNA CTD PMID:31533062 testosterone increases expression ISO IRS2 (Homo sapiens) 6480464 Testosterone results in increased expression of IRS2 mRNA CTD PMID:21632903 tetrachloroethene increases expression ISO Irs2 (Mus musculus) 6480464 Tetrachloroethylene results in increased expression of IRS2 mRNA CTD PMID:28973375 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of IRS2 protein CTD PMID:12629582 tetrachloromethane increases expression ISO Irs2 (Mus musculus) 6480464 Carbon Tetrachloride results in increased expression of IRS2 mRNA CTD PMID:31919559 thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of IRS2 mRNA CTD PMID:34492290 titanium dioxide increases expression ISO Irs2 (Mus musculus) 6480464 titanium dioxide analog results in increased expression of IRS2 mRNA and titanium dioxide results in increased expression of IRS2 mRNA CTD PMID:25111187 and PMID:29264374 trichloroethene increases expression EXP 6480464 Trichloroethylene results in increased expression of IRS2 mRNA CTD PMID:33387578 trichostatin A increases expression ISO IRS2 (Homo sapiens) 6480464 trichostatin A results in increased expression of IRS2 mRNA CTD PMID:24935251 and PMID:26272509 trichostatin A multiple interactions ISO IRS2 (Homo sapiens) 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS2 mRNA CTD PMID:27188386 triphenyl phosphate affects expression ISO Irs2 (Mus musculus) 6480464 triphenyl phosphate affects the expression of IRS2 mRNA CTD PMID:29316351 triphenyl phosphate affects expression EXP 6480464 triphenyl phosphate affects the expression of IRS2 mRNA CTD PMID:30589522 troglitazone increases expression ISO IRS2 (Homo sapiens) 6480464 troglitazone results in increased expression of IRS2 mRNA CTD PMID:19140230 tunicamycin increases expression ISO IRS2 (Homo sapiens) 6480464 Tunicamycin results in increased expression of IRS2 mRNA CTD PMID:29453283 urethane decreases expression ISO IRS2 (Homo sapiens) 6480464 Urethane results in decreased expression of IRS2 mRNA CTD PMID:28818685 ursodeoxycholic acid increases expression EXP 6480464 Ursodeoxycholic Acid results in increased expression of IRS2 mRNA CTD PMID:15885361 valproic acid increases methylation ISO IRS2 (Homo sapiens) 6480464 Valproic Acid results in increased methylation of IRS2 gene CTD PMID:29154799 valproic acid decreases expression EXP 6480464 Valproic Acid results in decreased expression of IRS2 mRNA CTD PMID:29427782 valproic acid increases expression ISO IRS2 (Homo sapiens) 6480464 Valproic Acid results in increased expression of IRS2 mRNA CTD PMID:26272509 and PMID:28001369 vanillic acid multiple interactions ISO IRS2 (Homo sapiens) 6480464 Vanillic Acid inhibits the reaction [INS protein results in decreased expression of IRS2 protein] CTD PMID:36764371 XL147 multiple interactions ISO Irs2 (Mus musculus) 6480464 XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of IRS2 mRNA] CTD PMID:29891994 zinc atom decreases expression ISO IRS2 (Homo sapiens) 6480464 Zinc results in decreased expression of IRS2 protein CTD PMID:19913001 zinc atom multiple interactions ISO Irs2 (Mus musculus) 6480464 [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of IRS2 mRNA CTD PMID:33549593 zinc(0) decreases expression ISO IRS2 (Homo sapiens) 6480464 Zinc results in decreased expression of IRS2 protein CTD PMID:19913001 zinc(0) multiple interactions ISO Irs2 (Mus musculus) 6480464 [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of IRS2 mRNA CTD PMID:33549593