Irs2 (insulin receptor substrate 2) - Rat Genome Database

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Gene: Irs2 (insulin receptor substrate 2) Rattus norvegicus
Symbol: Irs2
Name: insulin receptor substrate 2
RGD ID: 69316
Description: Enables several functions, including 14-3-3 protein binding activity; insulin receptor binding activity; and phosphatidylinositol 3-kinase binding activity. Involved in cellular response to glucose stimulus and insulin receptor signaling pathway. Predicted to be active in cytosol and plasma membrane. Biomarker of metabolic dysfunction-associated steatotic liver disease and osteoporosis. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human IRS2 (insulin receptor substrate 2); PARTICIPATES IN insulin signaling pathway; erythropoietin signaling pathway; insulin-like growth factor signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
Previously known as: 4PS; IRS-2; LOC207125; similar to aldolase; tyrosine kinase substrate
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Arunc2 Arunc1
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81685,190,310 - 85,214,543 (+)NCBIGRCr8
mRatBN7.21678,488,249 - 78,512,482 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1678,485,045 - 78,512,482 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1683,768,627 - 83,792,860 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01687,221,312 - 87,245,545 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01682,462,691 - 82,486,908 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01683,824,515 - 83,848,569 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1683,824,430 - 83,848,684 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01683,287,185 - 83,311,239 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41683,379,987 - 83,404,220 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11683,367,312 - 83,368,308 (+)NCBI
Celera1676,286,571 - 76,310,806 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-TEMPO  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
AM-251  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
avobenzone  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
boron nitride  (ISO)
bromobenzene  (EXP)
butanal  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
candesartan  (ISO)
carbon nanotube  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyanocob(III)alamin  (ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP)
D-glucose  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
furan  (EXP)
Ganoderic acid A  (ISO)
genistein  (ISO)
gentamycin  (EXP)
gingerol  (ISO)
glucose  (ISO)
glyburide  (EXP)
glycine betaine  (ISO)
glyphosate  (ISO)
hexadecanoic acid  (ISO)
indole-3-methanol  (EXP)
inulin  (ISO)
iron dichloride  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP)
lipopolysaccharide  (EXP)
lovastatin  (ISO)
LY294002  (ISO)
maneb  (ISO)
medroxyprogesterone acetate  (ISO)
melatonin  (ISO)
mercury dichloride  (EXP)
metformin  (EXP,ISO)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
myricetin  (EXP)
myrtenal  (EXP)
N(6)-butyryl-cAMP  (EXP)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
neomycin  (ISO)
nickel atom  (ISO)
nicotinamide  (EXP)
oleic acid  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phoxim  (EXP)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
quercetin  (EXP)
rac-lactic acid  (ISO)
ranitidine  (EXP)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP)
rottlerin  (EXP)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (EXP,ISO)
vanillic acid  (ISO)
XL147  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA,ISO,TAS)
plasma membrane  (IBA,ISO)


References - curated
# Reference Title Reference Citation
1. Short-term leptin-dependent inhibition of hepatic gluconeogenesis is mediated by insulin receptor substrate-2. Anderwald C, etal., Mol Endocrinol 2002 Jul;16(7):1612-28.
2. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
3. Assessment of the expression of IRbeta, IRS-1, IRS-2 and IGF-IRbeta in a rat model of intrauterine growth restriction. Bueno MP, etal., Fetal Diagn Ther. 2010;28(3):145-52. doi: 10.1159/000316932. Epub 2010 Aug 19.
4. Differential regulation of Kruppel-like factor family transcription factor expression in neonatal rat cardiac myocytes: effects of endothelin-1, oxidative stress and cytokines. Cullingford TE, etal., Biochim Biophys Acta. 2008 Jun;1783(6):1229-36. Epub 2008 Mar 25.
5. SH2-B promotes insulin receptor substrate 1 (IRS1)- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin. Duan C, etal., J Biol Chem. 2004 Oct 15;279(42):43684-91. Epub 2004 Aug 16.
6. Neuronal IGF-1 resistance reduces Abeta accumulation and protects against premature death in a model of Alzheimer's disease. Freude S, etal., FASEB J. 2009 Oct;23(10):3315-24. doi: 10.1096/fj.09-132043. Epub 2009 Jun 1.
7. HSP90 interacting with IRS-2 is involved in cAMP-dependent potentiation of IGF-I signals in FRTL-5 cells. Fukushima T, etal., Mol Cell Endocrinol. 2011 Sep 15;344(1-2):81-9. Epub 2011 Jul 1.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome. Hao CL, etal., J Food Biochem. 2019 Mar;43(3):e12769. doi: 10.1111/jfbc.12769. Epub 2019 Jan 13.
11. Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes. Hennige AM, etal., J Clin Invest. 2003 Nov;112(10):1521-32.
12. Modulation of IR/PTP1B interaction and downstream signaling in insulin sensitive tissues of MSG-rats. Hirata AE, etal., Life Sci. 2003 Aug 1;73(11):1369-81.
13. Insulin receptor substrate-2 is expressed in kidney epithelium and up-regulated in diabetic nephropathy. Hookham MB, etal., FEBS J. 2013 Jul;280(14):3232-43. doi: 10.1111/febs.12305. Epub 2013 May 29.
14. Regulation of IRS-2 signaling by IGF-1 receptor in the diabetic rat heart. Jiang Y and Steinle JJ, Can J Physiol Pharmacol. 2010 May;88(5):553-61.
15. Insulin signaling through insulin receptor substrate 1 and 2 in normal liver development. Khamzina L, etal., Gastroenterology 2003 Aug;125(2):572-85.
16. MicroRNAs: a new ray of hope for diabetes mellitus. Kumar M, etal., Protein Cell. 2012 Oct;3(10):726-38. doi: 10.1007/s13238-012-2055-0. Epub 2012 Oct 11.
17. Altered gene expression involved in insulin signaling pathway in type II diabetic osteoporosis rats model. Li B, etal., Endocrine. 2013 Feb;43(1):136-46. doi: 10.1007/s12020-012-9757-1. Epub 2012 Jul 22.
18. Specific regulation of IRS-2 expression by glucose in rat primary pancreatic islet beta-cells. Lingohr MK, etal., J Biol Chem. 2006 Jun 9;281(23):15884-92. Epub 2006 Mar 30.
19. Interaction between the G1057D variant of IRS-2 and overweight in the pathogenesis of type 2 diabetes. Mammarella S, etal., Hum Mol Genet. 2000 Oct 12;9(17):2517-21.
20. Regulation of synthesis and oxidation of fatty acids by adiponectin receptors (AdipoR1/R2) and insulin receptor substrate isoforms (IRS-1/-2) of the liver in a nonalcoholic steatohepatitis animal model. Matsunami T, etal., Metabolism. 2011 Jun;60(6):805-14. Epub 2010 Sep 16.
21. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
22. Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling. Moloney AM, etal., Neurobiol Aging. 2010 Feb;31(2):224-43. doi: 10.1016/j.neurobiolaging.2008.04.002. Epub .
23. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
24. Identification of the amino acids 300-600 of IRS-2 as 14-3-3 binding region with the importance of IGF-1/insulin-regulated phosphorylation of Ser-573. Neukamm SS, etal., PLoS One. 2012;7(8):e43296. doi: 10.1371/journal.pone.0043296. Epub 2012 Aug 17.
25. The haplotypes of the IRS-2 gene affect insulin sensitivity in Japanese patients with type 2 diabetes. Okazawa K, etal., Diabetes Res Clin Pract. 2005 Apr;68(1):39-48.
26. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
27. Early alterations in energy metabolism in the hippocampus of APPswe/PS1dE9 mouse model of Alzheimer's disease. Pedros I, etal., Biochim Biophys Acta. 2014 Sep;1842(9):1556-66. doi: 10.1016/j.bbadis.2014.05.025. Epub 2014 Jun 2.
28. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
29. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
30. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
31. Phosphoinositide 3-kinase-mediated reduction of insulin receptor substrate-1/2 protein expression via different mechanisms contributes to the insulin-induced desensitization of its signaling pathways in L6 muscle cells. Pirola L, etal., J Biol Chem 2003 May 2;278(18):15641-51. Epub 2003 Feb 18.
32. GOA pipeline RGD automated data pipeline
33. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
34. Comprehensive gene review and curation RGD comprehensive gene curation
35. Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. Schubert M, etal., J Neurosci 2003 Aug 6;23(18):7084-92.
Additional References at PubMed
PMID:11120660   PMID:11375348   PMID:12488434   PMID:12850284   PMID:12960006   PMID:12970360   PMID:14733908   PMID:15048126   PMID:15572028   PMID:15692808   PMID:16037383   PMID:16814735  
PMID:16921752   PMID:16925984   PMID:17299086   PMID:17332155   PMID:17636024   PMID:17662267   PMID:17761790   PMID:17901049   PMID:17925406   PMID:17993726   PMID:18590691   PMID:19088829  
PMID:19103603   PMID:19509476   PMID:19523444   PMID:19690174   PMID:19703555   PMID:21411721   PMID:21700708   PMID:21940781   PMID:22340657   PMID:22808485   PMID:23775122   PMID:24734256  
PMID:25036495   PMID:25879670   PMID:26027876   PMID:26657864   PMID:26919700   PMID:28065675   PMID:32045698   PMID:32631952   PMID:34189964  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81685,190,310 - 85,214,543 (+)NCBIGRCr8
mRatBN7.21678,488,249 - 78,512,482 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1678,485,045 - 78,512,482 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1683,768,627 - 83,792,860 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01687,221,312 - 87,245,545 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01682,462,691 - 82,486,908 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01683,824,515 - 83,848,569 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1683,824,430 - 83,848,684 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01683,287,185 - 83,311,239 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41683,379,987 - 83,404,220 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11683,367,312 - 83,368,308 (+)NCBI
Celera1676,286,571 - 76,310,806 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3813109,752,695 - 109,786,583 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13109,752,695 - 109,786,583 (-)EnsemblGRCh38hg38GRCh38
GRCh3713110,405,042 - 110,438,930 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3613109,204,185 - 109,236,915 (-)NCBINCBI36Build 36hg18NCBI36
Build 3413109,204,186 - 109,236,915NCBI
Celera1391,250,464 - 91,283,200 (-)NCBICelera
Cytogenetic Map13q34NCBI
HuRef1391,005,522 - 91,037,072 (-)NCBIHuRef
CHM1_113110,375,378 - 110,407,600 (-)NCBICHM1_1
T2T-CHM13v2.013108,981,231 - 109,015,226 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39811,034,681 - 11,058,929 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl811,034,681 - 11,058,458 (-)EnsemblGRCm39 Ensembl
GRCm38810,984,681 - 11,008,929 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl810,984,681 - 11,008,458 (-)EnsemblGRCm38mm10GRCm38
MGSCv37810,986,961 - 11,008,430 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36810,986,933 - 11,008,402 (-)NCBIMGSCv36mm8
Celera811,160,160 - 11,181,560 (-)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map85.35NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554042,531,484 - 2,555,689 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554042,531,484 - 2,555,383 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v214111,245,626 - 111,277,310 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan113109,927,626 - 109,959,400 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01390,886,095 - 90,917,724 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.113110,013,214 - 110,044,465 (-)NCBIpanpan1.1PanPan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12258,197,016 - 58,229,026 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2258,223,387 - 58,227,535 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2257,975,030 - 58,001,643 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02258,818,940 - 58,849,512 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2258,820,310 - 58,850,432 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12258,320,760 - 58,351,271 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02258,311,744 - 58,342,617 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02258,351,225 - 58,377,896 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024404945193,155,757 - 193,179,968 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049364722,772,187 - 2,796,398 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1176,626,179 - 76,653,881 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11176,626,158 - 76,654,639 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1388,045,439 - 88,076,468 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604644,755,670 - 44,786,671 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247932,614,589 - 2,636,947 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247932,615,092 - 2,636,835 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Irs2
149 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:308
Count of miRNA genes:192
Interacting mature miRNAs:235
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21678,511,380 - 78,511,550 (+)MAPPERmRatBN7.2
Rnor_6.01683,847,468 - 83,847,637NCBIRnor6.0
Rnor_5.01683,310,138 - 83,310,307UniSTSRnor5.0
RGSC_v3.41683,403,119 - 83,403,288UniSTSRGSC3.4
Celera1676,309,705 - 76,309,874UniSTS
Cytogenetic Map16q12.5UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21678,490,901 - 78,491,019 (+)MAPPERmRatBN7.2
Rnor_6.01683,827,168 - 83,827,285NCBIRnor6.0
Rnor_5.01683,289,838 - 83,289,955UniSTSRnor5.0
RGSC_v3.41683,382,640 - 83,382,757UniSTSRGSC3.4
Celera1676,289,224 - 76,289,341UniSTS
Cytogenetic Map16q12.5UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21678,488,775 - 78,489,171 (+)MAPPERmRatBN7.2
Rnor_6.01683,825,042 - 83,825,437NCBIRnor6.0
Rnor_5.01683,287,712 - 83,288,107UniSTSRnor5.0
RGSC_v3.41683,380,514 - 83,380,909UniSTSRGSC3.4
Celera1676,287,098 - 76,287,493UniSTS
Cytogenetic Map16q12.5UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 2 26 36 20 11 20 74 33 30 11
Low 1 17 21 21 8 21 8 11 2 11 8
Below cutoff


RefSeq Acc Id: ENSRNOT00000032918   ⟹   ENSRNOP00000036862
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1678,485,045 - 78,512,482 (+)Ensembl
Rnor_6.0 Ensembl1683,824,430 - 83,848,684 (+)Ensembl
RefSeq Acc Id: NM_001168633   ⟹   NP_001162104
Rat AssemblyChrPosition (strand)Source
GRCr81685,190,310 - 85,214,543 (+)NCBI
mRatBN7.21678,488,249 - 78,512,482 (+)NCBI
Rnor_6.01683,824,515 - 83,848,569 (+)NCBI
Rnor_5.01683,287,185 - 83,311,239 (+)NCBI
RGSC_v3.41683,379,987 - 83,404,220 (+)RGD
Celera1676,286,571 - 76,310,806 (+)RGD
Protein Sequences
Protein RefSeqs NP_001162104 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB49893 (Get FASTA)   NCBI Sequence Viewer  
  AAC05512 (Get FASTA)   NCBI Sequence Viewer  
  AAC33346 (Get FASTA)   NCBI Sequence Viewer  
  AAC36726 (Get FASTA)   NCBI Sequence Viewer  
  EDM08814 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000036862
RefSeq Acc Id: NP_001162104   ⟸   NM_001168633
- UniProtKB: F1MAL5 (UniProtKB/TrEMBL),   A6IWQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000036862   ⟸   ENSRNOT00000032918
Protein Domains
IRS-type PTB   PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1MAL5-F1-model_v2 AlphaFold F1MAL5 1-1327 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69316 AgrOrtholog
BioCyc Gene G2FUF-10640 BioCyc
Ensembl Genes ENSRNOG00000023509 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000032918 ENTREZGENE
  ENSRNOT00000032918.7 UniProtKB/TrEMBL
InterPro Insln_rcpt_S1 UniProtKB/TrEMBL
  PH_like_dom UniProtKB/TrEMBL
  Pleckstrin_homology UniProtKB/TrEMBL
KEGG Report rno:29376 UniProtKB/TrEMBL
  PTHR10614 UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
PhenoGen Irs2 PhenoGen
RatGTEx ENSRNOG00000023509 RatGTEx
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-04-12 Irs2  insulin receptor substrate 2  LOC207125  similar to aldolase  Data merged from RGD:708546 737654 PROVISIONAL
2010-05-06 LOC207125  similar to aldolase  LOC207125  unknown protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-28 LOC207125        Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Irs2  insulin receptor substrate 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference