Plcg1 (phospholipase C, gamma 1) - Rat Genome Database

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Gene: Plcg1 (phospholipase C, gamma 1) Rattus norvegicus
Symbol: Plcg1
Name: phospholipase C, gamma 1
RGD ID: 3347
Description: Enables several functions, including guanyl-nucleotide exchange factor activity; insulin receptor binding activity; and phospholipase C activity. Involved in several processes, including inositol trisphosphate biosynthetic process; phosphatidylinositol catabolic process; and response to curcumin. Located in clathrin-coated vesicle. Biomarker of acute myocardial infarction and colon cancer. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and lung non-small cell carcinoma. Orthologous to human PLCG1 (phospholipase C gamma 1); PARTICIPATES IN E-cadherin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; epidermal growth factor/neuregulin signaling pathway; INTERACTS WITH (+)-dihydromyricetin; (+)-schisandrin B; (R)-noradrenaline.
Type: protein-coding
Previously known as: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1; phosphoinositide phospholipase C; phosphoinositide phospholipase C-gamma-1; phospholipase C-gamma-1; PLC-148; PLC-gamma-1; PLC-II; PPLCA
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.23149,385,587 - 149,416,330 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3149,385,587 - 149,416,330 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3153,198,699 - 153,229,463 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03161,698,084 - 161,728,848 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03159,437,731 - 159,468,477 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03156,727,642 - 156,758,307 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3156,727,642 - 156,758,307 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03162,957,126 - 162,987,842 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43151,522,949 - 151,553,998 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13151,428,984 - 151,460,034 (+)NCBI
Celera3148,059,477 - 148,090,220 (+)NCBICelera
RH 3.4 Map31368.6RGD
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dihydromyricetin  (EXP)
(+)-schisandrin B  (EXP)
(R)-noradrenaline  (EXP)
(S)-nicotine  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-tribromophenol  (ISO)
2,6-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
acetaldehyde  (ISO)
acrylonitrile  (EXP)
aflatoxin B1  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
asbestos  (ISO)
auramine O  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
Brodifacoum  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
choline  (ISO)
chrysin  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
curcumin  (EXP)
cycloastragenol  (EXP)
deguelin  (ISO)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dioxygen  (EXP,ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
Evodiamine  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
genistein  (EXP)
ginsenoside Rg1  (ISO)
Heptachlor epoxide  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
imipramine  (ISO)
iodixanol  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
melittin  (EXP)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury(1+)  (ISO)
monosodium L-glutamate  (ISO)
N-acetylsphingosine  (ISO)
N-methylnicotinate  (ISO)
N-nitrosodiethylamine  (EXP)
nicotine  (EXP)
ochratoxin A  (ISO)
ouabain  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP)
PCB138  (ISO)
phenethyl caffeate  (EXP)
phenformin  (ISO)
phenylarsine oxide  (EXP,ISO)
phenylephrine  (EXP)
platycodin D  (ISO)
potassium dichromate  (ISO)
prazosin  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
procaine  (ISO)
quercetin  (ISO)
quinacrine  (ISO)
resveratrol  (EXP,ISO)
sodium arsenite  (ISO)
sulindac  (EXP)
tetrachloromethane  (EXP)
tetracycline  (ISO)
thimerosal  (ISO)
triadimefon  (ISO)
tributylstannane  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
U-73122  (EXP,ISO)
urethane  (ISO)
valproic acid  (ISO)
Vitisin A  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component


References - curated
# Reference Title Reference Citation
1. Elevated content of the tyrosine kinase substrate phospholipase C-gamma 1 in primary human breast carcinomas. Arteaga CL, etal., Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10435-9.
2. Identification of the changes in phospholipase C isozymes in ischemic-reperfused rat heart. Asemu G, etal., Arch Biochem Biophys 2003 Mar 15;411(2):174-82.
3. The selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding site. Bae JH, etal., Cell. 2009 Aug 7;138(3):514-24. doi: 10.1016/j.cell.2009.05.028.
4. Met, metastasis, motility and more. Birchmeier C, etal., Nat Rev Mol Cell Biol. 2003 Dec;4(12):915-25.
5. Interaction of elongation factor-1alpha and pleckstrin homology domain of phospholipase C-gamma 1 with activating its activity. Chang JS, etal., J Biol Chem 2002 May 31;277(22):19697-702.
6. Phospholipase C-gamma1 is a guanine nucleotide exchange factor for dynamin-1 and enhances dynamin-1-dependent epidermal growth factor receptor endocytosis. Choi JH, etal., J Cell Sci. 2004 Aug 1;117(Pt 17):3785-95. doi: 10.1242/jcs.01220. Epub 2004 Jul 13.
7. Phospholipase Cgamma1 negatively regulates growth hormone signalling by forming a ternary complex with Jak2 and protein tyrosine phosphatase-1B. Choi JH, etal., Nat Cell Biol. 2006 Dec;8(12):1389-97. Epub 2006 Nov 26.
8. Overexpression of kidney phosphatidylinositol 4-kinasebeta and phospholipase C(gamma1) proteins in two rodent models of polycystic kidney disease. Cuozzo FP, etal., Biochim Biophys Acta 2002 May 21;1587(1):99-106.
9. Characterization of Sam68-like mammalian proteins SLM-1 and SLM-2: SLM-1 is a Src substrate during mitosis. Di Fruscio M, etal., Proc Natl Acad Sci U S A 1999 Mar 16;96(6):2710-5.
10. Direct protein-protein interaction between PLCgamma1 and the bradykinin B2 receptor--importance of growth conditions. Duchene J, etal., Biochem Biophys Res Commun. 2005 Jan 28;326(4):894-900.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. The Met tyrosine kinase receptor in development and cancer. Gentile A, etal., Cancer Metastasis Rev. 2008 Mar;27(1):85-94.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. AP180 binds to the C-terminal SH2 domain of phospholipase C-gamma1 and inhibits its enzymatic activity. Han SJ, etal., Biochem Biophys Res Commun 2002 Jan 11;290(1):35-41.
15. Identification of p115 as a PLCgamma1-binding protein and the role of Src homology domains of PLCgamma1 in the vesicular transport. Han SJ, etal., Biochem Biophys Res Commun 2003 Jan 17;300(3):649-55.
16. Synapsin IIb interacts with the C-terminal SH2 and SH3 domains of PLCgamma1 and inhibits its enzymatic activity. Han SJ, etal., Cell Biol Int. 2004;28(12):943-8.
17. TRPC5 channel is the mediator of neurotrophin-3 in regulating dendritic growth via CaMKIIalpha in rat hippocampal neurons. He Z, etal., J Neurosci. 2012 Jul 4;32(27):9383-95. doi: 10.1523/JNEUROSCI.6363-11.2012.
18. Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition. Holmes K, etal., Cell Signal. 2007 Oct;19(10):2003-12. Epub 2007 Jun 12.
19. Reduced expression of E-cadherin and p120-catenin and elevated expression of PLC-gamma1 and PIKE are associated with aggressiveness of oral squamous cell carcinoma. Jiang Y, etal., Int J Clin Exp Pathol. 2015 Aug 1;8(8):9042-51. eCollection 2015.
20. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
21. Direct interaction of SOS1 Ras exchange protein with the SH3 domain of phospholipase C-gamma1. Kim MJ, etal., Biochemistry. 2000 Jul 25;39(29):8674-82.
22. Pleckstrin homology domain of phospholipase C-gamma1 directly binds to 68-kDa neurofilament light chain. Kim SK, etal., Exp Mol Med. 2006 Jun 30;38(3):265-72.
23. Enhanced expression of neuronal nitric oxide synthase and phospholipase C-gamma1 in regenerating murine neuronal cells by pulsed electromagnetic field. Kim SS, etal., Exp Mol Med 2002 Mar 31;34(1):53-9.
24. Downstream signaling molecules bind to different phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) peptides of the high affinity IgE receptor. Kimura T, etal., J Biol Chem. 1996 Nov 1;271(44):27962-8.
25. src-homology 2 (SH2) domain ligation as an allosteric regulator: modulation of phosphoinositide-specific phospholipase C gamma 1 structure and activity. Koblan KS, etal., Biochem J. 1995 Feb 1;305 ( Pt 3):745-51. doi: 10.1042/bj3050745.
26. Small GTPase Ras and Rho expression in rat osteoblasts during spaceflight. Kumei Y, etal., Ann N Y Acad Sci. 2007 Jan;1095:292-9.
27. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
28. Role of the pleckstrin homology domain of PLCgamma1 in its interaction with the insulin receptor. Kwon YK, etal., J Cell Biol 2003 Oct 27;163(2):375-84. Epub 2003 Oct 20.
29. Absence of erythrogenesis and vasculogenesis in Plcg1-deficient mice. Liao HJ, etal., J Biol Chem 2002 Mar 15;277(11):9335-41. Epub 2001 Dec 13.
30. Protein kinase C-gamma activation in the early streptozotocin diabetic rat lens. Lin D, etal., Curr Eye Res. 2007 Jun;32(6):523-32.
31. Phospholipase C-gamma1 is required for the activation of store-operated Ca2+ channels in liver cells. Litjens T, etal., Biochem J. 2007 Jul 15;405(2):269-76.
32. Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites. Lundby A, etal., Cell. 2019 Oct 3;179(2):543-560.e26. doi: 10.1016/j.cell.2019.09.008.
33. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
34. Effects of hyperoxia and acrylonitrile on the phospholipase C isozyme protein levels in rat heart and brain. Nagasawa K, etal., Life Sci 2003 Aug 1;73(11):1453-62.
35. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
36. Expression of phospholipase C-gamma 1 and its transcriptional regulators in breast cancer tissues. Noh DY, etal., Anticancer Res. 1998 Jul-Aug;18(4A):2643-8.
37. Elevated content of phospholipase C-gamma 1 in colorectal cancer tissues. Noh DY, etal., Cancer. 1994 Jan 1;73(1):36-41. doi: 10.1002/1097-0142(19940101)73:1<36::aid-cncr2820730108>;2-5.
38. Overexpression of phospholipase C-gamma 1 in familial adenomatous polyposis. Park JG, etal., Cancer Res. 1994 Apr 15;54(8):2240-4.
39. Phospholipase C-gamma is required for agonist-induced Ca2+ entry. Patterson RL, etal., Cell 2002 Nov 15;111(4):529-41.
40. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
41. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
42. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
43. Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound. Rao CV, etal., Cancer Res. 1995 Jan 15;55(2):259-66.
44. Polyamines are required for phospholipase C-gamma1 expression promoting intestinal epithelial restitution after wounding. Rao JN, etal., Am J Physiol Gastrointest Liver Physiol. 2007 Jan;292(1):G335-43. Epub 2006 Sep 14.
45. Selective targeting of ITK blocks multiple steps of HIV replication. Readinger JA, etal., Proc Natl Acad Sci U S A. 2008 May 6;105(18):6684-9. doi: 10.1073/pnas.0709659105. Epub 2008 Apr 28.
46. Application quantitative proteomics approach to identify differentially expressed proteins associated with cardiac protection mediated by cycloastragenol in acute myocardial infarction rats. Ren YS, etal., J Proteomics. 2020 Jun 30;222:103691. doi: 10.1016/j.jprot.2020.103691. Epub 2020 Feb 14.
47. GOA pipeline RGD automated data pipeline
48. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
49. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
50. PLCγ1 suppression promotes the adaptation of KRAS-mutant lung adenocarcinomas to hypoxia. Saliakoura M, etal., Nat Cell Biol. 2020 Nov;22(11):1382-1395. doi: 10.1038/s41556-020-00592-8. Epub 2020 Oct 19.
51. Signal transduction mechanisms in Alzheimer disease. Shimohama S and Matsushima H, Alzheimer Dis Assoc Disord. 1995;9 Suppl 2:15-22.
52. Inositol 5'-phosphatase, SHIP1 interacts with phospholipase C-gamma1 and modulates EGF-induced PLC activity. Song M, etal., Exp Mol Med. 2005 Jun 30;37(3):161-8.
53. Inositol phospholipid-specific phospholipase C: complete cDNA and protein sequences and sequence homology to tyrosine kinase-related oncogene products. Suh PG, etal., Proc Natl Acad Sci U S A 1988 Aug;85(15):5419-23.
54. Model establishment of prognostic-related immune genes in laryngeal squamous cell carcinoma. Sun M, etal., Medicine (Baltimore). 2021 Jan 15;100(2):e24263. doi: 10.1097/MD.0000000000024263.
55. Oncogenic role of phospholipase C-γ1 in progression of hepatocellular carcinoma. Tang W, etal., Hepatol Res. 2019 May;49(5):559-569. doi: 10.1111/hepr.13309. Epub 2019 Feb 20.
56. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
57. Phospholipase Cgamma1 controls surface expression of TRPC3 through an intermolecular PH domain. van Rossum DB, etal., Nature. 2005 Mar 3;434(7029):99-104.
58. Activation of H2O2-induced VSOR Cl- currents in HTC cells require phospholipase Cgamma1 phosphorylation and Ca2+ mobilisation. Varela D, etal., Cell Physiol Biochem. 2007;20(6):773-80.
59. Regulation of neuronal PLCgamma by chronic morphine. Wolf DH, etal., Brain Res. 2007 Jul 2;1156:9-20. Epub 2007 May 4.
60. PLCε1: a potential target of RNA interference therapy for gastric cancer. Yan F and Fu Q, Biochem Biophys Res Commun. 2014 Jun 13;448(4):409-13. doi: 10.1016/j.bbrc.2014.04.119. Epub 2014 May 2.
61. Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE. Ye K, etal., Nature. 2002 Jan 31;415(6871):541-4.
62. Personal Neoantigens From Patients With NSCLC Induce Efficient Antitumor Responses. Zhang W, etal., Front Oncol. 2021 Apr 13;11:628456. doi: 10.3389/fonc.2021.628456. eCollection 2021.
63. Phospholipase C gamma 1 is a potential prognostic biomarker for patients with locally advanced and resectable oral squamous cell carcinoma. Zhu D, etal., Int J Oral Maxillofac Surg. 2014 Dec;43(12):1418-26. doi: 10.1016/j.ijom.2014.07.001. Epub 2014 Jul 30.
Additional References at PubMed
PMID:2550068   PMID:8106527   PMID:8183574   PMID:8392838   PMID:8402898   PMID:8615781   PMID:11724770   PMID:12367511   PMID:12646582   PMID:12930795   PMID:14523024   PMID:14570902  
PMID:15161916   PMID:15169852   PMID:15258148   PMID:15488758   PMID:15536495   PMID:15579910   PMID:15607032   PMID:15702972   PMID:15728238   PMID:15865439   PMID:16038803   PMID:16321979  
PMID:16710293   PMID:16841466   PMID:16867273   PMID:16989733   PMID:17196935   PMID:17229814   PMID:17252537   PMID:17355934   PMID:17618160   PMID:18579528   PMID:18616564   PMID:19179337  
PMID:19208792   PMID:19505325   PMID:19538471   PMID:19605547   PMID:19717566   PMID:20011604   PMID:20164676   PMID:20807769   PMID:21210726   PMID:21360263   PMID:22390417   PMID:22454520  
PMID:22561606   PMID:22890232   PMID:23793062   PMID:24785188   PMID:25175053   PMID:26037503   PMID:26687682   PMID:27306412   PMID:27464494   PMID:27484337   PMID:28100486   PMID:28138157  
PMID:28698260   PMID:32868075   PMID:35848503  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.23149,385,587 - 149,416,330 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3149,385,587 - 149,416,330 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3153,198,699 - 153,229,463 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03161,698,084 - 161,728,848 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03159,437,731 - 159,468,477 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03156,727,642 - 156,758,307 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3156,727,642 - 156,758,307 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03162,957,126 - 162,987,842 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43151,522,949 - 151,553,998 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13151,428,984 - 151,460,034 (+)NCBI
Celera3148,059,477 - 148,090,220 (+)NCBICelera
RH 3.4 Map31368.6RGD
Cytogenetic Map3q42NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382041,137,543 - 41,177,626 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2041,136,960 - 41,196,801 (+)EnsemblGRCh38hg38GRCh38
GRCh372039,766,183 - 39,806,266 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362039,199,575 - 39,237,771 (+)NCBINCBI36Build 36hg18NCBI36
Build 342039,199,574 - 39,237,771NCBI
Celera2036,476,730 - 36,514,924 (+)NCBICelera
Cytogenetic Map20q12NCBI
HuRef2036,504,215 - 36,542,409 (+)NCBIHuRef
CHM1_12039,670,573 - 39,708,755 (+)NCBICHM1_1
T2T-CHM13v2.02042,868,611 - 42,909,312 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm392160,573,230 - 160,617,680 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2160,573,220 - 160,617,680 (+)EnsemblGRCm39 Ensembl
GRCm382160,731,310 - 160,775,760 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2160,731,300 - 160,775,760 (+)EnsemblGRCm38mm10GRCm38
MGSCv372160,557,046 - 160,601,496 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362160,422,751 - 160,467,201 (+)NCBIMGSCv36mm8
Celera2166,663,373 - 166,707,819 (+)NCBICelera
Cytogenetic Map2H2NCBI
cM Map280.97NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495544515,787,496 - 15,823,859 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544515,787,496 - 15,823,859 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan12046,871,882 - 46,910,654 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02037,477,077 - 37,515,854 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12038,577,199 - 38,615,149 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2038,572,709 - 38,615,145 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12429,198,536 - 29,213,899 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2429,198,556 - 29,214,714 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2428,823,106 - 28,859,401 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02429,883,241 - 29,919,530 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2429,883,201 - 29,919,502 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12429,152,120 - 29,188,420 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02429,256,001 - 29,292,271 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02429,752,157 - 29,788,483 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024408640178,117,909 - 178,150,680 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936561598,382 - 631,581 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936561598,372 - 631,575 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1743,810,048 - 43,844,554 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11743,810,003 - 43,844,553 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21749,203,540 - 49,238,416 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1222,599,547 - 22,638,394 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605071,416,788 - 71,455,730 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046249191,766,149 - 1,803,097 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249191,766,533 - 1,800,130 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Plcg1
59 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:556
Count of miRNA genes:256
Interacting mature miRNAs:331
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141339013162184794Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141339236155617360Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3145925360166177555Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3145925360166177555Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3145925360166177555Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3145925360166177555Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3145925360166177555Rat
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3145925360166177555Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145925360166177555Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145956084157309487Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3145956084161299569Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3149040888168026850Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23149,412,814 - 149,412,966 (+)MAPPERmRatBN7.2
Rnor_6.03156,754,792 - 156,754,943NCBIRnor6.0
Rnor_5.03162,984,327 - 162,984,478UniSTSRnor5.0
RGSC_v3.43151,550,483 - 151,550,634UniSTSRGSC3.4
Celera3148,086,703 - 148,086,854UniSTS
Cytogenetic Map3q42UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23149,415,194 - 149,415,372 (+)MAPPERmRatBN7.2
Rnor_6.03156,757,172 - 156,757,349NCBIRnor6.0
Rnor_5.03162,986,707 - 162,986,884UniSTSRnor5.0
RGSC_v3.43151,552,863 - 151,553,040UniSTSRGSC3.4
Celera3148,089,083 - 148,089,260UniSTS
RH 3.4 Map31368.6UniSTS
Cytogenetic Map3q42UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23149,414,351 - 149,414,633 (+)MAPPERmRatBN7.2
Rnor_6.03156,756,329 - 156,756,610NCBIRnor6.0
Rnor_5.03162,985,864 - 162,986,145UniSTSRnor5.0
RGSC_v3.43151,552,020 - 151,552,301UniSTSRGSC3.4
Celera3148,088,240 - 148,088,521UniSTS
Cytogenetic Map3q42UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23149,404,957 - 149,405,306 (+)MAPPERmRatBN7.2
Rnor_6.03156,746,935 - 156,747,283NCBIRnor6.0
Rnor_5.03162,976,470 - 162,976,818UniSTSRnor5.0
RGSC_v3.43151,542,626 - 151,542,974UniSTSRGSC3.4
Celera3148,078,846 - 148,079,194UniSTS
Cytogenetic Map3q42UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23149,412,572 - 149,412,817 (+)MAPPERmRatBN7.2
Rnor_6.03156,754,550 - 156,754,794NCBIRnor6.0
Rnor_5.03162,984,085 - 162,984,329UniSTSRnor5.0
Celera3148,086,461 - 148,086,705UniSTS
Cytogenetic Map3q42UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 43 52 36 19 36 2 5 74 35 41 11 2
Low 5 5 5 6 6 6
Below cutoff


RefSeq Acc Id: ENSRNOT00000078909   ⟹   ENSRNOP00000069822
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3149,385,587 - 149,416,330 (+)Ensembl
Rnor_6.0 Ensembl3156,727,642 - 156,758,307 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000118057   ⟹   ENSRNOP00000091002
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3149,385,587 - 149,416,330 (+)Ensembl
RefSeq Acc Id: NM_013187   ⟹   NP_037319
Rat AssemblyChrPosition (strand)Source
mRatBN7.23149,385,587 - 149,416,330 (+)NCBI
Rnor_6.03156,727,642 - 156,758,307 (+)NCBI
Rnor_5.03162,957,126 - 162,987,842 (+)NCBI
RGSC_v3.43151,522,949 - 151,553,998 (+)RGD
Celera3148,059,477 - 148,090,220 (+)RGD
RefSeq Acc Id: XM_039104387   ⟹   XP_038960315
Rat AssemblyChrPosition (strand)Source
mRatBN7.23149,385,645 - 149,414,681 (+)NCBI
Protein Sequences
Protein RefSeqs NP_037319 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960315 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41921 (Get FASTA)   NCBI Sequence Viewer  
  EDL96614 (Get FASTA)   NCBI Sequence Viewer  
  EDL96615 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000069822
GenBank Protein P10686 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037319   ⟸   NM_013187
- UniProtKB: P10686 (UniProtKB/Swiss-Prot),   G3V845 (UniProtKB/TrEMBL),   A6JWZ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069822   ⟸   ENSRNOT00000078909
RefSeq Acc Id: XP_038960315   ⟸   XM_039104387
- Peptide Label: isoform X1
- UniProtKB: A6JWZ2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000091002   ⟸   ENSRNOT00000118057
Protein Domains
C2   EF-hand   PH   PI-PLC X-box   PI-PLC Y-box   SH2   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P10686-F1-model_v2 AlphaFold P10686 1-1290 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3347 AgrOrtholog
BioCyc Gene G2FUF-46966 BioCyc
Ensembl Genes ENSRNOG00000051490 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000078909 ENTREZGENE
  ENSRNOT00000078909.2 UniProtKB/TrEMBL
  ENSRNOT00000118057.1 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand UniProtKB/Swiss-Prot
  SH3 Domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI-PLC_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLC-gamma UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLC-gamma_C-SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLC-gamma_N-SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLC-like_Pdiesterase_TIM-brl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLCgamma1_SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLipase_C_PInositol-sp_X_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLipase_C_Pinositol-sp_Y UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25738 UniProtKB/Swiss-Prot
PANTHER PTHR10336 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10336:SF173 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PF00168 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI-PLC-X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI-PLC-Y UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Plcg1 PhenoGen
PIRSF PLC-gamma UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIPLC_X_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIPLC_Y_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000051490 RatGTEx
SMART PLCXc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLCYc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49562 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51695 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC216671
  P10686 ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Plcg1  Phospholipase C, gamma 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction binds to SOS1, a p21 Ras-specific guanine nucleotide exchange factor, through its SH3 domain 729542
gene_physical_interaction protein interacts with Vdp, vesicle docking protein, through its SH2 and SH3 domains 734467
gene_process plays role in vesicle transport via its interaction with Vdp (vesicle docking protein) 734467
gene_regulation activated by tyrosine kinase receptors and nonreceptor tyrosine kinases 729542