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Gene: Met (MET proto-oncogene, receptor tyrosine kinase) Rattus norvegicus
Symbol: Met
Name: MET proto-oncogene, receptor tyrosine kinase
Description: Exhibits several functions, including beta-catenin binding activity; hepatocyte growth factor-activated receptor activity; and phospholipase binding activity. Involved in several processes, including nervous system development; regulation of cellular macromolecule biosynthetic process; and regulation of protein phosphorylation. Localizes to several cellular components, including postsynaptic density; postsynaptic membrane; and sperm flagellum. Biomarker of several diseases, including acute kidney failure; hepatobiliary system cancer (multiple); liver benign neoplasm; pancreatitis; and periodontitis. Human ortholog(s) of this gene implicated in autistic disorder; autosomal recessive nonsyndromic deafness 97; carcinoma (multiple); and multiple myeloma. Orthologous to human MET (MET proto-oncogene, receptor tyrosine kinase); PARTICIPATES IN scatter factor/hepatocyte growth factor signaling pathway; altered scatter factor/hepatocyte growth factor signaling pathway; E-cadherin signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-amino-2-deoxy-D-galactopyranose.
Type: protein-coding
Also known as: c-Met; hepatocyte growth factor receptor; HGF receptor; HGF/SF receptor; Hgfr; met proto-oncogene; met proto-oncogene tyrosine kinase; proto-oncogene c-Met; scatter factor receptor; SF receptor; tyrosine-protein kinase Met
Homo sapiens (human) : MET (MET proto-oncogene, receptor tyrosine kinase)  HGNC  Alliance
Mus musculus (house mouse) : Met (met proto-oncogene)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Met (MET proto-oncogene, receptor tyrosine kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : MET (MET proto-oncogene, receptor tyrosine kinase)
Canis lupus familiaris (dog) : MET (MET proto-oncogene, receptor tyrosine kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Met (MET proto-oncogene, receptor tyrosine kinase)
Sus scrofa (pig) : MET (MET proto-oncogene, receptor tyrosine kinase)
Chlorocebus sabaeus (African green monkey) : MET (MET proto-oncogene, receptor tyrosine kinase)
Heterocephalus glaber (naked mole-rat) : Met (MET proto-oncogene, receptor tyrosine kinase)
more info ...
Allele / Splice: Metem1Sage  
Genetic Models: SD-Metem1Sage
Is Marker For: Strains:   BB/OK  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0444,747,467 - 44,854,628 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl444,774,741 - 44,852,665 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0445,354,290 - 45,461,638 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4443,134,183 - 43,211,355 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1443,280,529 - 43,358,391 (+)NCBI
Celera441,091,921 - 41,169,063 (+)NCBICelera
Cytogenetic Map4q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Met
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3082
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.