Met (MET proto-oncogene, receptor tyrosine kinase) - Rat Genome Database

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Gene: Met (MET proto-oncogene, receptor tyrosine kinase) Rattus norvegicus
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Symbol: Met
Name: MET proto-oncogene, receptor tyrosine kinase
RGD ID: 3082
Description: Exhibits several functions, including beta-catenin binding activity; hepatocyte growth factor-activated receptor activity; and phospholipase binding activity. Involved in several processes, including animal organ development; nervous system development; and positive regulation of macromolecule metabolic process. Localizes to several cellular components, including postsynaptic density; postsynaptic membrane; and sperm flagellum. Biomarker of several diseases, including acute kidney failure; hepatobiliary system cancer (multiple); liver benign neoplasm; pancreatitis; and periodontitis. Human ortholog(s) of this gene implicated in autistic disorder; autosomal recessive nonsyndromic deafness 97; carcinoma (multiple); and multiple myeloma. Orthologous to human MET (MET proto-oncogene, receptor tyrosine kinase); PARTICIPATES IN scatter factor/hepatocyte growth factor signaling pathway; altered scatter factor/hepatocyte growth factor signaling pathway; E-cadherin signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: c-Met; hepatocyte growth factor receptor; HGF receptor; HGF/SF receptor; Hgfr; met proto-oncogene; met proto-oncogene tyrosine kinase; proto-oncogene c-Met; scatter factor receptor; SF receptor; tyrosine-protein kinase Met
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Metem1Sage  
Genetic Models: SD-Metem1Sage
Is Marker For: Strains:   BB/OK  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2445,790,456 - 45,898,139 (+)NCBI
Rnor_6.0 Ensembl444,774,741 - 44,852,665 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0444,747,467 - 44,854,628 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0445,354,290 - 45,461,638 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4443,134,183 - 43,211,355 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1443,280,529 - 43,358,391 (+)NCBI
Celera441,091,921 - 41,169,063 (+)NCBICelera
Cytogenetic Map4q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IEP)
Acute Liver Failure  (IEP)
acute myeloid leukemia  (ISO)
adenocarcinoma  (ISO)
Animal Disease Models  (ISO)
Animal Hepatitis  (IEP)
arteriosclerosis  (ISO)
autism spectrum disorder  (ISS)
autistic disorder  (ISO)
autosomal recessive nonsyndromic deafness 97  (ISO)
Bile Duct Neoplasms  (ISO)
breast cancer  (ISS)
breast carcinoma  (ISO)
Carcinogenesis  (ISO)
carcinoma  (ISO)
Cardiomegaly  (IEP)
childhood hepatocellular carcinoma  (ISO)
cholangiocarcinoma  (IEP,ISO)
Chronic Hepatitis  (ISO)
cognitive disorder  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
congenital diaphragmatic hernia  (ISO)
Copper-Overload Cirrhosis  (ISO)
Cystic, Mucinous, and Serous Neoplasms  (ISO)
disease of cellular proliferation  (ISO)
distal arthrogryposis type 1A  (ISO)
Endometrial Neoplasms  (IAGP)
Esophageal Neoplasms  (ISO)
Experimental Diabetes Mellitus  (IEP)
Experimental Liver Cirrhosis  (IEP)
Experimental Liver Neoplasms  (ISO)
Familial Mediterranean Fever, Autosomal Dominant  (ISO)
fatty liver disease  (ISO)
Gallbladder Neoplasms  (ISO)
gastrinoma  (ISO)
gestational diabetes  (ISS)
Gilles de la Tourette syndrome  (ISS)
glioblastoma  (ISO)
hepatocellular carcinoma  (IEP,ISO)
Hepatomegaly  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
high grade glioma  (IEP)
Hypertriglyceridemia  (ISO)
intellectual disability  (ISO)
invasive ductal carcinoma  (ISO)
Kidney Neoplasms  (ISO)
large cell carcinoma  (ISO)
liver benign neoplasm  (IEP)
lung carcinoma  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
lymphedema  (ISO)
malignant astrocytoma  (ISO)
malignant mesothelioma  (ISO)
melanoma  (ISO)
multiple myeloma  (ISO)
Nasal Polyps  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Nerve Sheath Neoplasms  (ISO)
neuroblastoma  (ISO)
non-alcoholic fatty liver disease  (ISO)
nonsyndromic deafness  (ISO)
oral squamous cell carcinoma  (ISO)
Osteofibrous Dysplasia  (ISO)
osteosarcoma  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (IEP,ISO)
pancreatic ductal carcinoma  (ISO)
pancreatitis  (IEP)
papillary renal cell carcinoma  (ISO)
periodontitis  (IEP)
pleomorphic xanthoastrocytoma  (ISO)
primary biliary cholangitis  (ISO)
prostate carcinoma  (ISO)
Prostatic Neoplasms  (ISO)
renal carcinoma  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (IEP)
sarcoma  (ISO)
schizophrenia  (ISO)
sinusitis  (ISO)
Spinal Cord Injuries  (IEP)
squamous cell carcinoma  (ISO)
Stomach Neoplasms  (ISO)
tongue squamous cell carcinoma  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-phenyl-1-cyclopentanecarboxylic acid 2-[2-(diethylamino)ethoxy]ethyl ester  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,3',4,4',5,5'-Heptachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-aminosalicylic acid  (ISO)
4-phenylbutyric acid  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
9-cis-retinoic acid  (ISO)
ABT-737  (ISO)
acetamide  (EXP)
acetic acid  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amodiaquine  (ISO)
apigenin  (ISO)
aristolochic acid  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bicalutamide  (ISO)
bilirubin IXalpha  (ISO)
biperiden  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromfenac  (ISO)
Butylparaben  (EXP)
C60 fullerene  (EXP)
cabozantinib  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cefaloridine  (EXP)
celecoxib  (EXP)
choline  (ISO)
cisplatin  (ISO)
clavulanic acid  (ISO)
clofarabine  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crizotinib  (ISO)
crocidolite asbestos  (EXP,ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
DDT  (ISO)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
Dibromoacetonitrile  (EXP)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entacapone  (ISO)
enzacamene  (EXP)
erlotinib hydrochloride  (ISO)
esmolol  (ISO)
ethambutol  (ISO)
ethanol  (EXP)
etodolac  (ISO)
Fexofenadine hydrochloride  (ISO)
fludrocortisone  (ISO)
flutamide  (ISO)
folic acid  (ISO)
furan  (EXP)
geldanamycin  (ISO)
genistein  (ISO)
ginsenoside Rg1  (ISO)
glutathione  (ISO)
graphite  (EXP)
heparin  (ISO)
hexadecanoic acid  (ISO)
Iproniazid  (ISO)
kaempferol  (ISO)
ketoconazole  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
lead nitrate  (ISO)
lead(0)  (EXP)
lead(2+)  (EXP)
leflunomide  (EXP)
licocoumarone  (ISO)
lipopolysaccharide  (EXP)
lumiracoxib  (ISO)
malonaldehyde  (ISO)
mebendazole  (ISO)
menadione  (ISO)
methotrexate  (ISO)
methyltestosterone  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
minoxidil  (ISO)
myricetin  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nefazodone  (ISO)
nevirapine  (ISO)
niclosamide  (EXP)
nimesulide  (ISO)
nomifensine  (ISO)
ochratoxin A  (ISO)
oleanolic acid  (ISO)
orlistat  (ISO)
oxybutynin  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
PCB138  (ISO)
PD173074  (ISO)
penbutolol  (ISO)
PHA-665752  (ISO)
phenobarbital  (ISO)
Phenoxybenzamine  (ISO)
phentolamine  (ISO)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
piperine  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
pirprofen  (ISO)
poly(propylene imine) macromolecule  (ISO)
potassium dichromate  (ISO)
prednisolone  (ISO)
procyclidine  (ISO)
protriptyline  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
retinyl acetate  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
sodium aurothiomalate  (ISO)
sodium cholate  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tanespimycin  (EXP,ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thymoquinone  (ISO)
tienilic acid  (ISO)
titanium dioxide  (ISO)
tolcapone  (ISO)
trazodone  (ISO)
triazines  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
Trihexyphenidyl  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
Tungsten carbide  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
vemurafenib  (ISO)
vinclozolin  (EXP)
zafirlukast  (ISO)
zearalenone  (ISO)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult behavior  (ISO)
brain development  (IEP,ISO)
branching morphogenesis of an epithelial tube  (IEA,ISO)
cardiac muscle cell development  (ISO)
cardiac muscle contraction  (ISO)
cell aging  (IEP)
cell migration  (IBA)
cellular response to arsenic-containing substance  (IEP)
cellular response to glucose stimulus  (IEP)
cellular response to growth factor stimulus  (IEP)
cellular response to inorganic substance  (IEP)
cellular response to interleukin-6  (IEP)
cellular response to peptide hormone stimulus  (IEP)
central nervous system neuron differentiation  (IEP)
chemical synaptic transmission  (ISO)
endothelial cell morphogenesis  (IEA,ISO)
establishment of skin barrier  (IEA,ISO)
excitatory postsynaptic potential  (ISO)
flagellated sperm motility  (IMP)
glucose homeostasis  (ISO)
hepatocyte growth factor receptor signaling pathway  (ISO)
lactation  (IEP)
liver development  (IBA,IEP,ISO)
male gonad development  (IEP)
modulation of chemical synaptic transmission  (ISO)
muscle cell migration  (ISO)
muscle organ development  (ISO)
myoblast proliferation  (ISO)
myotube differentiation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of guanyl-nucleotide exchange factor activity  (IEA,ISO)
negative regulation of hydrogen peroxide-mediated programmed cell death  (IEA,ISO)
negative regulation of peptidyl-threonine phosphorylation  (IMP)
negative regulation of Rho protein signal transduction  (IEA,ISO)
negative regulation of stress fiber assembly  (IEA,ISO)
negative regulation of thrombin-activated receptor signaling pathway  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IMP)
negative regulation of transforming growth factor beta production  (ISO)
nervous system development  (IBA)
neuron differentiation  (IBA)
neuron migration  (IDA,IMP)
oligodendrocyte development  (IEP)
pancreas development  (IBA,IEP)
peptidyl-tyrosine phosphorylation  (IEA)
phagocytosis  (IBA)
placenta development  (ISO)
positive chemotaxis  (IEA,ISO,ISS)
positive regulation of dendrite morphogenesis  (IMP)
positive regulation of DNA replication  (IMP)
positive regulation of endothelial cell chemotaxis  (IEA,ISO,ISS)
positive regulation of gene expression  (IMP)
positive regulation of glucose transmembrane transport  (ISO)
positive regulation of kinase activity  (IBA)
positive regulation of MAPK cascade  (ISO)
positive regulation of microtubule polymerization  (IEA,ISO)
positive regulation of mitotic nuclear division  (IMP)
positive regulation of neuron projection development  (IMP)
positive regulation of p38MAPK cascade  (ISO)
positive regulation of peptidyl-serine phosphorylation  (IMP)
positive regulation of peptidyl-threonine phosphorylation  (IMP)
positive regulation of protein kinase B signaling  (IBA)
positive regulation of transcription by RNA polymerase II  (IEA,IMP,ISO)
protein autophosphorylation  (IDA,ISO)
reactive oxygen species metabolic process  (ISO)
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling  (ISO)
regulation of cellular response to oxidative stress  (ISO)
regulation of interleukin-6 production  (ISO)
response to acidic pH  (IEP)
response to drug  (IEP)
response to organic cyclic compound  (IEP)
response to peptide hormone  (IEP)
response to wounding  (IEP)
semaphorin-plexin signaling pathway  (IEA,ISO,ISS)
skeletal muscle tissue development  (ISO)
transmembrane receptor protein tyrosine kinase signaling pathway  (IBA,IEA)

References

References - curated
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93. Zeng G, etal., Exp Cell Res. 2006 Nov 1;312(18):3620-30. Epub 2006 Aug 10.
Additional References at PubMed
PMID:7565774   PMID:7651534   PMID:8166728   PMID:9271668   PMID:11061428   PMID:12397180   PMID:12538467   PMID:12543460   PMID:12897086   PMID:14500721   PMID:14517989   PMID:15218527  
PMID:15314156   PMID:15376315   PMID:16049329   PMID:16153003   PMID:16192631   PMID:16465395   PMID:16537482   PMID:16804967   PMID:16867273   PMID:18819921   PMID:19581412   PMID:19850054  
PMID:20539003   PMID:20624990   PMID:20655899   PMID:20814222   PMID:21072211   PMID:21134835   PMID:21490227   PMID:22245998   PMID:22521434   PMID:23024263   PMID:23348694   PMID:23618918  
PMID:23994610   PMID:25168379   PMID:25198505   PMID:25277788   PMID:25674220   PMID:26972715   PMID:28679425  


Genomics

Candidate Gene Status
Met is a candidate Gene for QTL Hcar2
Comparative Map Data
Met
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2445,790,456 - 45,898,139 (+)NCBI
Rnor_6.0 Ensembl444,774,741 - 44,852,665 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0444,747,467 - 44,854,628 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0445,354,290 - 45,461,638 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4443,134,183 - 43,211,355 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1443,280,529 - 43,358,391 (+)NCBI
Celera441,091,921 - 41,169,063 (+)NCBICelera
Cytogenetic Map4q21NCBI
MET
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7116,672,196 - 116,798,377 (+)EnsemblGRCh38hg38GRCh38
GRCh387116,672,196 - 116,798,386 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh377116,312,250 - 116,438,431 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367116,099,695 - 116,225,676 (+)NCBINCBI36hg18NCBI36
Build 347115,906,409 - 116,032,390NCBI
Celera7111,119,882 - 111,245,969 (+)NCBI
Cytogenetic Map7q31.2NCBI
HuRef7110,678,023 - 110,804,134 (+)NCBIHuRef
CHM1_17116,246,063 - 116,372,044 (+)NCBICHM1_1
CRA_TCAGchr7v27115,707,906 - 115,833,890 (+)NCBI
Met
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39617,463,351 - 17,573,979 (+)NCBIGRCm39mm39
GRCm39 Ensembl617,463,799 - 17,573,979 (+)Ensembl
GRCm38617,463,349 - 17,573,980 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl617,463,800 - 17,573,980 (+)EnsemblGRCm38mm10GRCm38
MGSCv37617,413,957 - 17,523,980 (+)NCBIGRCm37mm9NCBIm37
MGSCv36617,441,241 - 17,521,823 (+)NCBImm8
Celera617,538,386 - 17,649,457 (+)NCBICelera
Cytogenetic Map6A2NCBI
cM Map67.83NCBI
Met
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543222,440,637 - 22,517,647 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543222,440,671 - 22,519,592 (+)NCBIChiLan1.0ChiLan1.0
MET
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17121,365,429 - 121,468,159 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7121,365,438 - 121,468,159 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v07108,646,278 - 108,772,238 (+)NCBIMhudiblu_PPA_v0panPan3
MET
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11455,599,047 - 55,711,626 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1455,598,337 - 55,724,027 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1455,021,838 - 55,105,272 (+)NCBI
ROS_Cfam_1.01455,639,647 - 55,766,100 (+)NCBI
UMICH_Zoey_3.11455,696,450 - 55,779,874 (+)NCBI
UNSW_CanFamBas_1.01455,384,675 - 55,468,117 (+)NCBI
UU_Cfam_GSD_1.01455,755,770 - 55,839,237 (+)NCBI
Met
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511844,299,687 - 44,409,065 (+)NCBI
SpeTri2.0NW_0049365892,280,803 - 2,390,179 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MET
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1829,426,044 - 29,541,512 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11829,426,044 - 29,541,526 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21831,646,160 - 31,693,836 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MET
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12185,370,574 - 85,486,405 (+)NCBI
ChlSab1.1 Ensembl2185,397,645 - 85,488,093 (+)Ensembl
Vero_WHO_p1.0NW_02366604218,245,769 - 18,362,778 (-)NCBI
Met
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248272,589,157 - 2,724,065 (-)NCBI

Position Markers
Met  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2445,819,539 - 45,819,609 (+)MAPPER
Rnor_6.0444,776,028 - 44,776,097NCBIRnor6.0
Rnor_5.0445,383,042 - 45,383,111UniSTSRnor5.0
RGSC_v3.4443,134,878 - 43,134,947UniSTSRGSC3.4
Celera441,092,616 - 41,092,685UniSTS
Cytogenetic Map4q21UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4304323179575658Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)43043231145254791Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4304401755791834Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4304401764915903Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4304780755324857Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)4734240492484039Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)47850904182171018Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4805218953052189Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)4805218953052189Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)4805218953052189Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4805218953052189Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4805218953052189Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)4805218953052189Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41263897457638974Rat
7387227Uae40Urinary albumin excretion QTL 402.90.0052urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)41614994161149941Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)41822218761039065Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)423850384169318094Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42399172176238799Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42399172176238799Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)42463187469631874Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42665474981874227Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)429549895112807890Rat
11530004Niddm71Non-insulin dependent diabetes mellitus QTL 710.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)43155448451311866Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43182556083531021Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43182556083531021Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43182556083531021Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)43363780361708341Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)43427793299067150Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)436615599145611886Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)43768517573066691Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)43770327275345433Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)437703272115372927Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)43920822284208222Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)43920824784208247Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44241577787415777Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)443414605155469929Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)443414792146942075Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)443414792146942075Rat


Related Rat Strains
The following Strains have been annotated to Met


Genetic Models
This gene Met is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:107
Count of miRNA genes:79
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000009662
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 38 28 6 28 8 8 11 35 28 11 8
Low 1 35 19 13 13 13 3 59 12
Below cutoff 7 4 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000086902   ⟹   ENSRNOP00000070486
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl444,774,741 - 44,852,665 (+)Ensembl
RefSeq Acc Id: NM_031517   ⟹   NP_113705
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2445,818,845 - 45,896,016 (+)NCBI
Rnor_6.0444,775,333 - 44,852,505 (+)NCBI
Rnor_5.0445,354,290 - 45,461,638 (+)NCBI
RGSC_v3.4443,134,183 - 43,211,355 (+)RGD
Celera441,091,921 - 41,169,063 (+)RGD
Sequence:
RefSeq Acc Id: XM_006236129   ⟹   XP_006236191
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2445,790,458 - 45,898,139 (+)NCBI
Rnor_6.0444,747,467 - 44,854,628 (+)NCBI
Rnor_5.0445,354,290 - 45,461,638 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039107024   ⟹   XP_038962952
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2445,790,456 - 45,898,139 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_113705   ⟸   NM_031517
- Peptide Label: precursor
- UniProtKB: P97523 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006236191   ⟸   XM_006236129
- Peptide Label: isoform X1
- UniProtKB: Q2IBC7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070486   ⟸   ENSRNOT00000086902
RefSeq Acc Id: XP_038962952   ⟸   XM_039107024
- Peptide Label: isoform X2
Protein Domains
IPT/TIG   Protein kinase   Sema

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3082 AgrOrtholog
Ensembl Genes ENSRNOG00000052745 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000070486 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000086902 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_E-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IPT_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Plexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Plexin_repeat UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PSI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Semap_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Semap_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_HGF/MSP_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24553 UniProtKB/Swiss-Prot
NCBI Gene 24553 ENTREZGENE
PANTHER PTHR22625 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PSI UniProtKB/TrEMBL
  Sema UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB MET RGD
PhenoGen Met PhenoGen
PIRSF TyrPK_HGF-R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SEMA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IPT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PSI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sema UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF101912 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81296 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JY19_RAT UniProtKB/TrEMBL
  MET_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q2IBC7 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary P97579 UniProtKB/Swiss-Prot
  Q63119 UniProtKB/Swiss-Prot
  Q63964 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-07-10 Met  MET proto-oncogene, receptor tyrosine kinase  Met  met proto-oncogene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Met  met proto-oncogene      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization C-Met codes for a 190 kDa transmembrane tyrosine kinase receptor 70321
gene_disease upregulated in hormone-dependent endometrial cancers 70557
gene_expression expressed in uterus 70557
gene_function receptor tyrosine kinase, receptor for hepatocyte growth factor  
gene_process has a role in cell signalling 70348
gene_process variant forms may be involved in oncogenesis 70557
gene_process may be involved in rat liver regeneration 729166
gene_product glycoprotein consisting of 1382 amino acids 70321