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Gene: Hgf (hepatocyte growth factor) Rattus norvegicus
Symbol: Hgf
Name: hepatocyte growth factor
Description: Exhibits growth factor activity. Involved in several processes, including animal organ regeneration; hyaluronan metabolic process; and positive regulation of nervous system development. Localizes to extracellular space. Used to study brain infarction. Biomarker of cholangiocarcinoma. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autosomal recessive nonsyndromic deafness 39; eye disease (multiple); neuropathy (multiple); and scleroderma (multiple). Orthologous to human HGF (hepatocyte growth factor); PARTICIPATES IN E-cadherin signaling pathway; fibroblast growth factor signaling pathway; scatter factor/hepatocyte growth factor signaling pathway; INTERACTS WITH (-)-citrinin; 17beta-estradiol; 17beta-estradiol 17-glucosiduronic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: hepatocyte growth factor (scatter factor); hepatopoeitin-A; hepatopoietin-A; HPTA; scatter factor; SF
Homo sapiens (human) : HGF (hepatocyte growth factor)  HGNC  Alliance
Mus musculus (house mouse) : Hgf (hepatocyte growth factor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hgf (hepatocyte growth factor)
Pan paniscus (bonobo/pygmy chimpanzee) : HGF (hepatocyte growth factor)
Canis lupus familiaris (dog) : HGF (hepatocyte growth factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hgf (hepatocyte growth factor)
Sus scrofa (pig) : HGF (hepatocyte growth factor)
Chlorocebus sabaeus (African green monkey) : HGF (hepatocyte growth factor)
Heterocephalus glaber (naked mole-rat) : Hgf (hepatocyte growth factor)
more info ...
Is Marker For: Strains:   BB/OK  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0415,435,460 - 15,505,377 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl415,433,295 - 15,505,362 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0415,408,857 - 15,478,988 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4414,864,357 - 14,932,513 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1414,864,356 - 14,932,513 (-)NCBI
Celera414,212,976 - 14,281,167 (-)NCBICelera
Cytogenetic Map4q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Hgf
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2794
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.