Hgf (hepatocyte growth factor) - Rat Genome Database

Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer VCMap
Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Hgf (hepatocyte growth factor) Rattus norvegicus
Analyze
Symbol: Hgf
Name: hepatocyte growth factor
RGD ID: 2794
Description: Enables growth factor activity. Involved in several processes, including positive regulation of angiogenesis; positive regulation of myelination; and positive regulation of neuron projection regeneration. Located in extracellular space. Used to study brain infarction. Biomarker of cholangiocarcinoma. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autosomal recessive nonsyndromic deafness 39; eye disease (multiple); neuropathy (multiple); and scleroderma (multiple). Orthologous to human HGF (hepatocyte growth factor); PARTICIPATES IN E-cadherin signaling pathway; fibroblast growth factor signaling pathway; scatter factor/hepatocyte growth factor signaling pathway; INTERACTS WITH (-)-citrinin; (S)-nicotine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hepatocyte growth factor (scatter factor); hepatopoeitin-A; hepatopoietin-A; HPTA; scatter factor; SF
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   BB/OK  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2418,673,736 - 18,745,582 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl418,677,101 - 18,745,409 (-)Ensembl
Rnor_6.0415,435,460 - 15,505,377 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl415,433,295 - 15,505,362 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0415,408,857 - 15,478,988 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4414,864,357 - 14,932,513 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1414,864,356 - 14,932,513 (-)NCBI
Celera414,212,976 - 14,281,167 (-)NCBICelera
Cytogenetic Map4q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Liver Failure  (ISO)
acute myeloid leukemia  (ISO)
adult-onset Still's disease  (ISO)
angle-closure glaucoma  (ISO)
arteriosclerosis  (ISO)
atrial fibrillation  (ISO)
autosomal recessive nonsyndromic deafness 39  (ISO)
Barrett's esophagus  (ISO)
biliary tract benign neoplasm  (ISO)
bilirubin metabolic disorder  (ISO)
brain infarction  (IDA)
breast cancer  (ISS)
cardiomyopathy  (ISO)
carotid artery disease  (ISO)
central nervous system disease  (ISO)
cholangiocarcinoma  (IEP,ISO)
cholesteatoma  (ISO)
Choroidal Neovascularization  (IEP)
Chronic Hepatitis  (ISO)
Copper-Overload Cirrhosis  (ISO)
coronary artery disease  (ISO)
COVID-19  (ISO)
dermatomyositis  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
Experimental Diabetes Mellitus  (IEP)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Melanoma  (ISO)
Experimental Neoplasms  (ISO)
Facial Nerve Injuries  (IDA)
Gallbladder Neoplasms  (ISO)
Graft vs Host Disease  (ISO)
Hearing Loss  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
hypertension  (ISO)
interstitial lung disease  (ISO)
inverted papilloma  (ISO)
keratoconus  (ISO)
Lentigo  (ISO)
Limb Ischemia  (ISO)
liver cirrhosis  (ISO)
Liver Injury  (ISO)
Liver Neoplasms  (ISO)
localized scleroderma  (ISO)
malignant astrocytoma  (ISO)
malignant mesothelioma  (ISO)
meningioma  (ISO)
Metabolic Syndrome  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
myopia  (ISO)
myositis  (ISO)
Nasal Polyps  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
neovascular inflammatory vitreoretinopathy  (ISO)
Nerve Sheath Neoplasms  (ISO)
neuroblastoma  (ISO)
obesity  (ISO)
Optic Nerve Injuries  (ISO)
Pain  (ISO)
pancreatic cancer  (ISO)
pancreatitis  (ISO)
Parkinson's disease  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
polymyositis  (ISO)
Polyomavirus Infections  (ISO)
pulmonary fibrosis  (ISO)
Reperfusion Injury  (ISO)
Retina Reperfusion Injury  (IEP,ISO)
retinal degeneration  (ISO)
Retinal Neovascularization  (ISO)
retinitis pigmentosa  (ISO)
retinopathy of prematurity  (ISO)
rheumatoid arthritis  (ISO)
Rhinosinusitis  (ISO)
schizophrenia  (ISO)
sciatic neuropathy  (ISO)
Skin Neoplasms  (ISO)
Spinal Cord Injuries  (IDA,IEP,ISO)
squamous cell carcinoma  (ISO)
Stroke  (IDA)
systemic scleroderma  (ISO)
thrombosis  (ISO)
tongue squamous cell carcinoma  (ISO)
vascular disease  (ISO)
visual epilepsy  (ISO)
vitiligo  (ISO)
Wounds and Injuries  (ISO)
Wounds, Penetrating  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-citrinin  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(5Z,8Z,11Z,13E)-15-HETE  (ISO)
(S)-nicotine  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 17-glucosiduronic acid  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (EXP)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
9-cis-retinoic acid  (ISO)
ABT-737  (ISO)
acetamide  (EXP)
acetic acid  (EXP)
acetylsalicylic acid  (ISO)
actinomycin D  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
aspartame  (ISO)
atazanavir sulfate  (ISO)
benazepril  (EXP)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
beraprost  (ISO)
berberine  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP,ISO)
bromosulfophthalein  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (EXP,ISO)
captan  (ISO)
chenodeoxycholic acid  (ISO)
CHIR 99021  (ISO)
choline  (ISO)
ciprofibrate  (EXP)
cisplatin  (ISO)
clothianidin  (ISO)
cortisol  (ISO)
crizotinib  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
DDT  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibromoacetonitrile  (EXP)
diethyl malate  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
efavirenz  (ISO)
entinostat  (ISO)
ethanol  (ISO)
etodolac  (ISO)
folic acid  (ISO)
genistein  (ISO)
glutathione  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
heparin  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
isoniazide  (ISO)
isotretinoin  (ISO)
kaempferol  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (EXP,ISO)
melphalan  (ISO)
mercury dichloride  (EXP)
methapyrilene  (ISO)
monosodium L-glutamate  (ISO)
myricetin  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
nefazodone  (ISO)
nevirapine  (ISO)
nicotine  (EXP,ISO)
nifedipine  (ISO)
nitrofen  (EXP)
NS-398  (ISO)
ochratoxin A  (EXP)
orphenadrine  (EXP)
ouabain  (EXP)
oxilofrine  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PD173074  (ISO)
perfluorodecanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
PHA-665752  (ISO)
phenobarbital  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
prostaglandin E2  (EXP)
Ptaquiloside  (ISO)
pyrithione  (ISO)
quercetin  (ISO)
quercitrin  (ISO)
raloxifene  (ISO)
reactive oxygen species  (EXP,ISO)
reserpine  (EXP)
resveratrol  (EXP,ISO)
riddelliine  (EXP)
rifampicin  (ISO)
rofecoxib  (ISO)
roxarsone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
salubrinal  (EXP)
SB 431542  (ISO)
Securinine  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sorafenib  (ISO)
sphingosine 1-phosphate  (ISO)
sulfasalazine  (ISO)
sulindac sulfide  (ISO)
Sunset Yellow FCF  (ISO)
tacrine  (EXP)
tamoxifen  (ISO)
taurochenodeoxycholic acid  (ISO)
taurocholic acid  (EXP)
telmisartan  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thapsigargin  (EXP)
thioacetamide  (EXP,ISO)
titanium dioxide  (EXP,ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
tunicamycin  (EXP)
ursodeoxycholic acid  (EXP,ISO)
valproic acid  (ISO)
valsartan  (EXP)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vemurafenib  (ISO)
vorinostat  (ISO)
XAV939  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (IEP)
cell chemotaxis  (ISO)
cell morphogenesis  (ISO)
cellular response to hepatocyte growth factor stimulus  (ISO)
epithelial cell proliferation  (ISO)
hepatocyte growth factor receptor signaling pathway  (IBA,ISO)
liver development  (ISO)
myoblast proliferation  (ISO)
negative regulation of apoptotic process  (IBA,IDA)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
negative regulation of hydrogen peroxide-mediated programmed cell death  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of interleukin-6 production  (ISO)
negative regulation of peptidyl-serine phosphorylation  (ISO)
negative regulation of release of cytochrome c from mitochondria  (ISO)
positive chemotaxis  (IEA)
positive regulation of angiogenesis  (IDA)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (TAS)
positive regulation of DNA biosynthetic process  (ISO)
positive regulation of interleukin-10 production  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of myelination  (IDA)
positive regulation of neuron projection regeneration  (IDA)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (ISO)
positive regulation of protein phosphorylation  (IBA)
proteolysis  (IEA)
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling  (ISO)
regulation of p38MAPK cascade  (ISO)
regulation of tau-protein kinase activity  (ISO)
skeletal muscle cell proliferation  (IEA,ISO)

Cellular Component

Molecular Function

References

References - curated
1. Arrieta O, etal., Cancer. 2002 Jun 15;94(12):3210-8.
2. Asami O, etal., J Biochem (Tokyo). 1991 Jan;109(1):8-13.
3. Balaban YH, etal., Indian J Gastroenterol. 2006 Jul-Aug;25(4):223-4.
4. Birchmeier C, etal., Nat Rev Mol Cell Biol. 2003 Dec;4(12):915-25.
5. Briggs MC, etal., Invest Ophthalmol Vis Sci. 2000 Sep;41(10):3085-94.
6. Castano R, etal., Otolaryngol Head Neck Surg. 2010 May;142(5):665-71.e1-2. doi: 10.1016/j.otohns.2010.01.004.
7. Colombo ES, etal., Invest Ophthalmol Vis Sci. 2007 Apr;48(4):1793-800.
8. Crljen V, etal., Biochem J 2002 Aug 1;365(Pt 3):791-9.
9. Esaki S, etal., Gene Ther. 2011 Nov;18(11):1063-9. doi: 10.1038/gt.2011.57. Epub 2011 May 12.
10. Frost J, etal., Rheumatology (Oxford). 2012 Jun;51(6):1049-52. doi: 10.1093/rheumatology/ker367. Epub 2012 Jan 27.
11. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Gentile A, etal., Cancer Metastasis Rev. 2008 Mar;27(1):85-94.
13. GOA data from the GO Consortium
14. Han W, etal., Invest Ophthalmol Vis Sci. 2006 Jun;47(6):2291-9.
15. Hansel DE, etal., Am J Pathol. 2003 Jul;163(1):217-29.
16. Hashimoto N, etal., Mod Rheumatol. 2003 Jun;13(2):129-34. doi: 10.3109/s10165-002-0211-8.
17. Hasuike S, etal., J Gastroenterol Hepatol. 2005 Nov;20(11):1753-61.
18. Hernandez C, etal., Diabetes Metab. 2004 Sep;30(4):341-6.
19. Hiratsuka A, etal., J Clin Endocrinol Metab. 2005 May;90(5):2927-31. Epub 2005 Feb 15.
20. Hoshino K, etal., Arthritis Rheum. 2011 Aug;63(8):2465-72. doi: 10.1002/art.30415.
21. Hu W, etal., Exp Eye Res. 2009 Jan;88(1):79-91. doi: 10.1016/j.exer.2008.10.014. Epub 2008 Nov 1.
22. Iwasaki T, etal., Arthritis Res Ther. 2006;8(6):R161.
23. Jiang Z, etal., PLoS One. 2013 Apr 9;8(4):e60950. doi: 10.1371/journal.pone.0060950. Print 2013.
24. Kadoya A, etal., Nihon Rinsho Meneki Gakkai Kaishi. 1996 Oct;19(5):488-97.
25. Kagawa T, etal., Nephron Physiol. 2006;102(3-4):p92-102. Epub 2005 Dec 6.
26. Kato N, etal., Diabetes. 2005 Mar;54(3):846-54.
27. Katoh H, etal., Clin Exp Pharmacol Physiol. 2004 Mar;31(3):145-51.
28. Kemik O, etal., Bratisl Lek Listy. 2009;110(10):627-9.
29. Kim CH, etal., Head Neck. 2010 Dec;32(12):1655-64. doi: 10.1002/hed.21383.
30. Kitamura K, etal., J Neurosci Res. 2007 Aug 15;85(11):2332-42.
31. Kitamura K, etal., PLoS One. 2011;6(11):e27706. doi: 10.1371/journal.pone.0027706. Epub 2011 Nov 29.
32. Kovacs D, etal., Br J Dermatol. 2010 Nov;163(5):1020-7. doi: 10.1111/j.1365-2133.2010.09946.x.
33. Kunugiza Y, etal., Gene Ther. 2006 Aug;13(15):1143-52. Epub 2006 Mar 30.
34. Kurita K, etal., J Invest Dermatol. 2005 Sep;125(3):538-44.
35. Kuroiwa T, etal., J Clin Invest. 2001 Jun;107(11):1365-73.
36. Lai GH, etal., Hepatology. 2000 Jun;31(6):1257-65.
37. Lashkari K, etal., Am J Pathol. 2000 Apr;156(4):1337-44.
38. Lionetti V, etal., J Biol Chem. 2010 Mar 26;285(13):9949-61. doi: 10.1074/jbc.M109.087254. Epub 2010 Jan 22.
39. Liu QJ, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2005 Nov;17(11):675-8.
40. Machida S, etal., Invest Ophthalmol Vis Sci. 2004 Nov;45(11):4174-82.
41. Mendieta-Condado E, etal., J Pharmacol Exp Ther. 2009 Oct;331(1):122-32. Epub 2009 Jul 28.
42. MGD data from the GO Consortium
43. Miyagawa S, etal., Transplantation. 2006 Mar 27;81(6):902-7.
44. Morishita R, etal., Hypertension. 2004 Aug;44(2):203-9. Epub 2004 Jul 6.
45. Motone M, etal., Hypertens Res. 2004 Apr;27(4):247-51.
46. Naeem A, etal., J Neurobiol 2002 May;51(2):101-14.
47. Naim R, etal., Acta Otolaryngol. 2004 Jun;124(5):563-8.
48. NCBI rat LocusLink and RefSeq merged data July 26, 2002
49. Nishimori H, etal., Pancreas. 2002 Apr;24(3):242-50.
50. Nishimura M, etal., J Hypertens. 1997 Oct;15(10):1137-42.
51. Noonan FP, etal., Cancer Res. 2000 Jul 15;60(14):3738-43.
52. Nowak M, etal., Endokrynol Pol. 2008 Jan-Feb;59(1):2-5.
53. OMIM Disease Annotation Pipeline
54. Online Mendelian Inheritance in Man, OMIM (TM).
55. Ono K, etal., Bone. 2006 Jul;39(1):27-34. Epub 2006 Feb 3.
56. Oshima K, etal., FASEB J. 2004 Jan;18(1):212-4. Epub 2003 Nov 20.
57. Otsuka T, etal., Cancer Res. 1998 Nov 15;58(22):5157-67.
58. Otsuka T, etal., Mol Cell Biol. 2000 Mar;20(6):2055-65.
59. Pandey J and Wendell DL, Mamm Genome. 2006 Jan;17(1):49-57. Epub 2006 Jan 13.
60. Pipeline to import KEGG annotations from KEGG into RGD
61. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
62. Price JA, etal., Hepatology 2002 Nov;36(5):1089-97.
63. Rao UN, etal., Hum Pathol. 1997 Sep;28(9):1066-70.
64. Rehman J, etal., J Am Coll Cardiol. 2003 Apr 16;41(8):1408-13.
65. RGD automated data pipeline
66. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
67. RGD automated import pipeline for gene-chemical interactions
68. Rho HS, etal., Arch Otolaryngol Head Neck Surg. 2006 Sep;132(9):985-9.
69. Saghizadeh M, etal., Invest Ophthalmol Vis Sci. 2005 Oct;46(10):3604-15.
70. Sahebjada S, etal., PLoS One. 2014 Jan 8;9(1):e84067. doi: 10.1371/journal.pone.0084067. eCollection 2014.
71. Salom D, etal., Invest Ophthalmol Vis Sci. 2010 Jun;51(6):3157-61. doi: 10.1167/iovs.09-4390. Epub 2010 Jan 6.
72. Satani K, etal., Diabet Med. 2006 Jun;23(6):617-22.
73. Schultz JM, etal., Am J Hum Genet. 2009 Jul;85(1):25-39. doi: 10.1016/j.ajhg.2009.06.003. Epub 2009 Jul 2.
74. Shibuki H, etal., Invest Ophthalmol Vis Sci. 2002 Feb;43(2):528-36.
75. Soeki T, etal., Circ J. 2002 Nov;66(11):1003-7.
76. Sun W, etal., Brain Res Mol Brain Res 2002 Jun 30;103(1-2):36-48.
77. Suzuki S, etal., Biochem Biophys Res Commun 2002 Apr 5;292(3):709-14.
78. Tanaka T, etal., Cancer Gene Ther. 2004 Jun;11(6):431-40.
79. Tashiro K, etal., Proc Natl Acad Sci U S A 1990 Apr;87(8):3200-4.
80. Tatsumi R, etal., Mol Biol Cell 2002 Aug;13(8):2909-18.
81. Tomiya T, etal., Biochem Biophys Res Commun 2002 Oct 11;297(5):1108-11.
82. Tonges L, etal., J Neurochem. 2011 Jun;117(5):892-903. doi: 10.1111/j.1471-4159.2011.07257.x. Epub 2011 Apr 26.
83. Tsuboi Y, etal., Acta Neurol Scand. 2002 Aug;106(2):99-103.
84. Tsuchihara T, etal., Mol Ther. 2009 Jan;17(1):42-50. doi: 10.1038/mt.2008.214. Epub 2008 Oct 21.
85. Uzumcu M, etal., Reproduction. 2006 Aug;132(2):291-9.
86. Walentinsson A, etal., Cancer Res 2001 Nov 15;61(22):8263-73.
87. Walentinsson A, etal., Mamm Genome 2001 Dec;12(12):900-8.
88. Wang P, etal., Invest Ophthalmol Vis Sci. 2009 Apr;50(4):1546-51. doi: 10.1167/iovs.08-2537. Epub 2008 Dec 5.
89. Watanabe K, etal., Cardiovasc Drugs Ther. 2001 Mar;15(2):147-53.
90. Wu MH, etal., Gene Ther. 2004 Jan;11(2):170-80.
91. Yamaguchi Y, etal., Dig Dis Sci. 1997 Mar;42(3):522-8.
92. Yang Y, etal., J Allergy Clin Immunol. 2020 Apr 29. pii: S0091-6749(20)30576-5. doi: 10.1016/j.jaci.2020.04.027.
93. Yanovitch T, etal., Mol Vis. 2009 May 20;15:1028-35.
94. Yuan L, etal., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012 Apr;26(8):339-42.
95. Zhao MZ, etal., J Cereb Blood Flow Metab. 2006 Sep;26(9):1176-88. Epub 2006 Jan 18.
Additional References at PubMed
PMID:2146117   PMID:2531289   PMID:7953556   PMID:11061428   PMID:11744165   PMID:11832492   PMID:11839582   PMID:11976737   PMID:12042032   PMID:12127815   PMID:12130561   PMID:12163028  
PMID:12969135   PMID:14517989   PMID:14654226   PMID:15153551   PMID:15287857   PMID:15314156   PMID:15326485   PMID:15336531   PMID:15389661   PMID:15505094   PMID:16097045   PMID:16115399  
PMID:16164627   PMID:16386592   PMID:16410125   PMID:16415345   PMID:16543637   PMID:16549518   PMID:16596271   PMID:16786119   PMID:16880525   PMID:16884699   PMID:17124385   PMID:17204247  
PMID:17242177   PMID:17294746   PMID:17382307   PMID:17383528   PMID:17427161   PMID:17466941   PMID:17471308   PMID:17667812   PMID:17767955   PMID:17804794   PMID:17923118   PMID:17940345  
PMID:17975841   PMID:18031729   PMID:18067924   PMID:18199534   PMID:18351465   PMID:18824844   PMID:18979225   PMID:18988920   PMID:19069655   PMID:19095317   PMID:19292056   PMID:19434765  
PMID:19720831   PMID:19834131   PMID:19946888   PMID:20175208   PMID:20404049   PMID:20466058   PMID:20624990   PMID:20655899   PMID:20814222   PMID:20963849   PMID:21072211   PMID:21075102  
PMID:21134835   PMID:21245381   PMID:21643626   PMID:21843593   PMID:21931759   PMID:22165288   PMID:22245998   PMID:22318499   PMID:22361334   PMID:22661380   PMID:22897854   PMID:23024263  
PMID:23270462   PMID:23273597   PMID:23933910   PMID:23954444   PMID:23994610   PMID:24122166   PMID:24370951   PMID:24490163   PMID:24782653   PMID:24815169   PMID:24840640   PMID:25062485  
PMID:25063067   PMID:25099287   PMID:25277788   PMID:25736907   PMID:25793303   PMID:25862490   PMID:25920966   PMID:26213907   PMID:27036872   PMID:27129877   PMID:27480986   PMID:28279229  
PMID:28844859   PMID:29442198   PMID:29932234   PMID:30816491   PMID:30873677   PMID:31337959   PMID:31411175   PMID:31781338   PMID:33670243   PMID:33860459  


Genomics

Candidate Gene Status
Hgf is a candidate Gene for QTL Hcar2
Comparative Map Data
Hgf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2418,673,736 - 18,745,582 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl418,677,101 - 18,745,409 (-)Ensembl
Rnor_6.0415,435,460 - 15,505,377 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl415,433,295 - 15,505,362 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0415,408,857 - 15,478,988 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4414,864,357 - 14,932,513 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1414,864,356 - 14,932,513 (-)NCBI
Celera414,212,976 - 14,281,167 (-)NCBICelera
Cytogenetic Map4q12NCBI
HGF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38781,699,010 - 81,770,047 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl781,699,010 - 81,770,438 (-)EnsemblGRCh38hg38GRCh38
GRCh37781,328,326 - 81,399,363 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36781,169,380 - 81,237,388 (-)NCBINCBI36hg18NCBI36
Build 34781,024,867 - 81,044,103NCBI
Celera776,032,788 - 76,100,524 (-)NCBI
Cytogenetic Map7q21.11NCBI
HuRef775,935,402 - 76,003,191 (-)NCBIHuRef
CHM1_1781,261,794 - 81,329,511 (-)NCBICHM1_1
T2T-CHM13v2.0782,951,060 - 83,022,099 (-)NCBI
CRA_TCAGchr7v2780,663,506 - 80,731,238 (-)NCBI
Hgf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39516,758,493 - 16,827,448 (+)NCBIGRCm39mm39
GRCm39 Ensembl516,758,493 - 16,825,150 (+)Ensembl
GRCm38516,553,495 - 16,619,439 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl516,553,495 - 16,620,152 (+)EnsemblGRCm38mm10GRCm38
MGSCv37516,059,368 - 16,125,257 (+)NCBIGRCm37mm9NCBIm37
MGSCv36516,065,374 - 16,131,263 (+)NCBImm8
Celera513,552,002 - 13,617,800 (+)NCBICelera
Cytogenetic Map5A3NCBI
cM Map57.07NCBI
Hgf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554104,114,778 - 4,182,058 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554104,114,280 - 4,181,953 (+)NCBIChiLan1.0ChiLan1.0
HGF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1787,325,741 - 87,396,850 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl787,327,798 - 87,397,811 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0773,667,618 - 73,738,960 (-)NCBIMhudiblu_PPA_v0panPan3
HGF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11821,329,688 - 21,410,257 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1821,332,817 - 21,410,263 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1821,005,145 - 21,082,437 (-)NCBI
ROS_Cfam_1.01821,778,181 - 21,858,827 (-)NCBI
ROS_Cfam_1.0 Ensembl1821,778,229 - 21,858,761 (-)Ensembl
UMICH_Zoey_3.11821,417,964 - 21,495,307 (-)NCBI
UNSW_CanFamBas_1.01820,953,619 - 21,030,809 (-)NCBI
UU_Cfam_GSD_1.01821,607,548 - 21,684,870 (-)NCBI
Hgf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511863,151,279 - 63,227,083 (-)NCBI
SpeTri2.0NW_004936734354,798 - 428,356 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HGF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl998,437,087 - 98,513,156 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1998,437,771 - 98,513,573 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29108,765,929 - 108,841,386 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HGF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12167,118,785 - 67,193,506 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2167,120,722 - 67,193,504 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604236,762,736 - 36,834,784 (-)NCBIVero_WHO_p1.0
Hgf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473930,236,146 - 30,307,356 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462473930,233,589 - 30,307,508 (-)NCBIHetGla_female_1.0hetGla2


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4127716890Rat
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4127716890Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4127716890Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4129494328Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4130372989Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4131934116Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4131934116Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4131934116Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4131934116Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4132584199Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4133250345Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4133250345Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
1358201Gluco12Glucose level QTL121.6adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake (CMO:0000870)4521839229593287Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4994088544463908Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41002490139524530Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat


Related Rat Strains
The following Strains have been annotated to Hgf

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:28
Count of miRNA genes:23
Interacting mature miRNAs:28
Transcripts:ENSRNOT00000009763
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 18 18 5 18 7 9 11
Low 3 37 39 23 14 23 8 8 52 28 26 8
Below cutoff 6 3 22 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000009763   ⟹   ENSRNOP00000009764
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl418,677,101 - 18,745,409 (-)Ensembl
Rnor_6.0 Ensembl415,433,295 - 15,505,362 (-)Ensembl
RefSeq Acc Id: NM_017017   ⟹   NP_058713
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2418,677,101 - 18,745,303 (-)NCBI
Rnor_6.0415,436,662 - 15,505,283 (-)NCBI
Rnor_5.0415,408,857 - 15,478,988 (-)NCBI
RGSC_v3.4414,864,357 - 14,932,513 (-)RGD
Celera414,212,976 - 14,281,167 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006235979   ⟹   XP_006236041
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2418,673,736 - 18,745,209 (-)NCBI
Rnor_6.0415,435,460 - 15,505,377 (-)NCBI
Rnor_5.0415,408,857 - 15,478,988 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039107016   ⟹   XP_038962944
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2418,673,736 - 18,745,582 (-)NCBI
RefSeq Acc Id: XM_039107017   ⟹   XP_038962945
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2418,673,736 - 18,745,582 (-)NCBI
RefSeq Acc Id: XM_039107018   ⟹   XP_038962946
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2418,673,736 - 18,745,209 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_058713   ⟸   NM_017017
- Peptide Label: preproprotein
- UniProtKB: P17945 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006236041   ⟸   XM_006235979
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000009764   ⟸   ENSRNOT00000009763
RefSeq Acc Id: XP_038962945   ⟸   XM_039107017
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038962944   ⟸   XM_039107016
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038962946   ⟸   XM_039107018
- Peptide Label: isoform X2
Protein Domains
Kringle   PAN   Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P17945-F1-model_v2 AlphaFold P17945 1-728 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2794 AgrOrtholog
BioCyc Gene G2FUF-45898 BioCyc
Ensembl Genes ENSRNOG00000007027 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000009764 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000009763 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot
  2.40.20.10 UniProtKB/Swiss-Prot
InterPro Hepatocyte_GF UniProtKB/Swiss-Prot
  HGF-like UniProtKB/Swiss-Prot
  Kringle UniProtKB/Swiss-Prot
  Kringle-like UniProtKB/Swiss-Prot
  Kringle_CS UniProtKB/Swiss-Prot
  Kringle_sf UniProtKB/Swiss-Prot
  Pan_app UniProtKB/Swiss-Prot
  Peptidase_S1_PA UniProtKB/Swiss-Prot
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot
  Peptidase_S1A UniProtKB/Swiss-Prot
  Trypsin_dom UniProtKB/Swiss-Prot
KEGG Report rno:24446 UniProtKB/Swiss-Prot
NCBI Gene 24446 ENTREZGENE
Pfam Kringle UniProtKB/Swiss-Prot
  PAN_1 UniProtKB/Swiss-Prot
  Trypsin UniProtKB/Swiss-Prot
PhenoGen Hgf PhenoGen
PIRSF Hepatocyte_GF UniProtKB/Swiss-Prot
  HGF_MST1 UniProtKB/Swiss-Prot
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot
PROSITE KRINGLE_1 UniProtKB/Swiss-Prot
  KRINGLE_2 UniProtKB/Swiss-Prot
  PAN UniProtKB/Swiss-Prot
  TRYPSIN_DOM UniProtKB/Swiss-Prot
SMART PAN_AP UniProtKB/Swiss-Prot
  SM00130 UniProtKB/Swiss-Prot
  Tryp_SPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot
  SSF57440 UniProtKB/Swiss-Prot
UniProt HGF_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-11-06 Hgf  hepatocyte growth factor    Hepatocyte growth factor (scatter factor)  Name updated 625702 APPROVED
2002-06-10 Hgf  Hepatocyte growth factor (scatter factor)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease upregulated in uterine tumors 70557
gene_expression expressed in uterus 70557