Hgf (hepatocyte growth factor) - Rat Genome Database

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Gene: Hgf (hepatocyte growth factor) Rattus norvegicus
Symbol: Hgf
Name: hepatocyte growth factor
RGD ID: 2794
Description: Enables growth factor activity. Involved in several processes, including positive regulation of angiogenesis; positive regulation of myelination; and positive regulation of neuron projection regeneration. Located in extracellular space. Used to study brain infarction. Biomarker of cholangiocarcinoma. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autosomal recessive nonsyndromic deafness 39; eye disease (multiple); neuropathy (multiple); and scleroderma (multiple). Orthologous to human HGF (hepatocyte growth factor); PARTICIPATES IN E-cadherin signaling pathway; fibroblast growth factor signaling pathway; scatter factor/hepatocyte growth factor signaling pathway; INTERACTS WITH (-)-citrinin; (S)-nicotine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hepatocyte growth factor (scatter factor); hepatopoeitin-A; hepatopoietin-A; HPTA; scatter factor; SF
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   BB/OK  
Candidate Gene For: Hcar2
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2418,673,736 - 18,745,582 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl418,677,101 - 18,745,409 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx423,828,584 - 23,896,754 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0419,645,467 - 19,713,646 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0418,026,554 - 18,094,730 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0415,435,460 - 15,505,377 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl415,433,295 - 15,505,362 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0415,408,857 - 15,478,988 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4414,864,357 - 14,932,513 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1414,864,356 - 14,932,513 (-)NCBI
Celera414,212,976 - 14,281,167 (-)NCBICelera
Cytogenetic Map4q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
Acute Liver Failure  (ISO)
acute myeloid leukemia  (ISO)
adult-onset Still's disease  (ISO)
angle-closure glaucoma  (ISO)
arteriosclerosis  (ISO)
atrial fibrillation  (ISO)
autism spectrum disorder  (ISO)
autosomal recessive nonsyndromic deafness 39  (ISO,ISS)
Barrett's esophagus  (ISO)
biliary tract benign neoplasm  (ISO)
bilirubin metabolic disorder  (ISO)
brain infarction  (IDA)
cardiomyopathy  (ISO)
carotid artery disease  (ISO)
central nervous system disease  (ISO)
CHARGE syndrome  (ISO)
cholangiocarcinoma  (IEP,ISO)
cholesteatoma  (ISO)
Choroidal Neovascularization  (IEP)
Chronic Hepatitis  (ISO)
Copper-Overload Cirrhosis  (ISO)
coronary artery disease  (ISO)
dermatomyositis  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
epilepsy  (ISO)
Experimental Diabetes Mellitus  (IEP)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Melanoma  (ISO)
Experimental Neoplasms  (ISO)
Facial Nerve Injuries  (IDA)
Gallbladder Neoplasms  (ISO)
genetic disease  (ISO)
graft-versus-host disease  (ISO)
Hearing Loss  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
hypertension  (ISO)
interstitial lung disease  (ISO)
inverted papilloma  (ISO)
keratoconus  (ISO)
Lentigo  (ISO)
limb ischemia  (ISO)
liver cirrhosis  (ISO)
Liver Injury  (ISO)
Liver Neoplasms  (ISO)
localized scleroderma  (ISO)
malignant astrocytoma  (ISO)
malignant mesothelioma  (ISO)
meningioma  (ISO)
Metabolic Syndrome  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
myopia  (ISO)
myositis  (ISO)
Nasal Polyps  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
neovascular inflammatory vitreoretinopathy  (ISO)
Nerve Sheath Neoplasms  (ISO)
neuroblastoma  (ISO)
obesity  (ISO)
Optic Nerve Injuries  (ISO)
Pain  (ISO)
pancreatic cancer  (ISO)
pancreatitis  (ISO)
Parkinson's disease  (ISO)
Penetrating Wounds  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
polymyositis  (ISO)
Polyomavirus Infections  (ISO)
pulmonary fibrosis  (ISO)
Reperfusion Injury  (ISO)
Retina Reperfusion Injury  (IEP,ISO)
retinal degeneration  (ISO)
Retinal Neovascularization  (ISO)
retinitis pigmentosa  (ISO)
retinopathy of prematurity  (ISO)
rheumatoid arthritis  (ISO)
Rhinosinusitis  (ISO)
schizophrenia  (ISO)
sciatic neuropathy  (ISO)
Skin Neoplasms  (ISO)
Spinal Cord Injuries  (IDA,IEP,ISO)
squamous cell carcinoma  (ISO)
Stroke  (IDA)
systemic scleroderma  (ISO)
thrombosis  (ISO)
tongue squamous cell carcinoma  (ISO)
vascular disease  (ISO)
vitiligo  (ISO)
Wounds and Injuries  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-citrinin  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(5Z,8Z,11Z,13E)-15-HETE  (ISO)
(S)-nicotine  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 17-glucosiduronic acid  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (EXP)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
9-cis-retinoic acid  (ISO)
ABT-737  (ISO)
acetamide  (EXP)
acetic acid  (EXP)
acetylsalicylic acid  (ISO)
actinomycin D  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
aspartame  (ISO)
atazanavir sulfate  (ISO)
benazepril  (EXP)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
beraprost  (ISO)
berberine  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP,ISO)
bromosulfophthalein  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (EXP,ISO)
captan  (ISO)
chenodeoxycholic acid  (ISO)
CHIR 99021  (ISO)
choline  (ISO)
ciprofibrate  (EXP)
cisplatin  (ISO)
clothianidin  (ISO)
cortisol  (ISO)
crizotinib  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibromoacetonitrile  (EXP)
Dictamnine  (ISO)
diethyl malate  (ISO)
dioxygen  (ISO)
diquat  (ISO)
disodium selenite  (ISO)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
efavirenz  (ISO)
entinostat  (ISO)
ethanol  (ISO)
etodolac  (ISO)
folic acid  (ISO)
genistein  (ISO)
glutathione  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
heparin  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
isoniazide  (ISO)
isotretinoin  (ISO)
kaempferol  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (EXP,ISO)
melphalan  (ISO)
mercury dichloride  (EXP)
methapyrilene  (ISO)
monosodium L-glutamate  (ISO)
myricetin  (ISO)
N-acetyl-L-cysteine  (ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
nefazodone  (ISO)
nevirapine  (ISO)
nicotine  (EXP,ISO)
nifedipine  (ISO)
nitrofen  (EXP)
NS-398  (ISO)
NSC 23766  (ISO)
ochratoxin A  (EXP)
orphenadrine  (EXP)
ouabain  (EXP)
oxilofrine  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PD173074  (ISO)
perfluorodecanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
PHA-665752  (ISO)
phenobarbital  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propofol  (ISO)
prostaglandin E2  (EXP)
Ptaquiloside  (ISO)
pyrithione  (ISO)
quercetin  (ISO)
quercitrin  (ISO)
raloxifene  (ISO)
reactive oxygen species  (EXP,ISO)
reserpine  (EXP)
resveratrol  (EXP,ISO)
riddelliine  (EXP)
rifampicin  (ISO)
rofecoxib  (ISO)
roxarsone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
salubrinal  (EXP)
SB 431542  (ISO)
Securinine  (ISO)
sevoflurane  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sorafenib  (ISO)
sphingosine 1-phosphate  (ISO)
sulfasalazine  (ISO)
sulindac sulfide  (ISO)
Sunset Yellow FCF  (ISO)
tacrine  (EXP)
tamoxifen  (ISO)
taurochenodeoxycholic acid  (ISO)
taurocholic acid  (EXP)
telmisartan  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thapsigargin  (EXP)
thioacetamide  (EXP,ISO)
titanium dioxide  (EXP,ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
tunicamycin  (EXP)
ursodeoxycholic acid  (EXP,ISO)
valproic acid  (ISO)
valsartan  (EXP)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vemurafenib  (ISO)
vorinostat  (ISO)
XAV939  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (IEP)
cell chemotaxis  (IEA,ISO)
cell morphogenesis  (IEA,ISO)
cellular response to hepatocyte growth factor stimulus  (IEA,ISO)
epithelial cell proliferation  (IEA,ISO)
hepatocyte growth factor receptor signaling pathway  (IBA,IEA,ISO)
liver development  (IEA,ISO)
myoblast proliferation  (IEA,ISO)
negative regulation of apoptotic process  (IBA,IDA)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (IEA,ISO)
negative regulation of hydrogen peroxide-mediated programmed cell death  (IEA,ISO)
negative regulation of inflammatory response  (IEA,ISO)
negative regulation of interleukin-6 production  (IEA,ISO)
negative regulation of peptidyl-serine phosphorylation  (IEA,ISO)
negative regulation of release of cytochrome c from mitochondria  (IEA,ISO)
positive chemotaxis  (IEA)
positive regulation of angiogenesis  (IDA)
positive regulation of cell migration  (IEA,ISO)
positive regulation of cell population proliferation  (TAS)
positive regulation of DNA biosynthetic process  (IEA,ISO)
positive regulation of interleukin-10 production  (IEA,ISO)
positive regulation of MAPK cascade  (IEA,ISO)
positive regulation of myelination  (IDA)
positive regulation of neuron projection regeneration  (IDA)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA,ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
positive regulation of protein phosphorylation  (IBA)
proteolysis  (IEA)
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling  (IEA,ISO)
regulation of p38MAPK cascade  (IEA,ISO)
skeletal muscle cell proliferation  (IEA,ISO)

Cellular Component


References - curated
# Reference Title Reference Citation
1. Hepatocyte growth factor is associated with poor prognosis of malignant gliomas and is a predictor for recurrence of meningioma. Arrieta O, etal., Cancer. 2002 Jun 15;94(12):3210-8.
2. Purification and characterization of hepatocyte growth factor from injured liver of carbon tetrachloride-treated rats. Asami O, etal., J Biochem (Tokyo). 1991 Jan;109(1):8-13.
3. Hepatocellular carcinoma and cholangiocarcinoma are associated with high serum levels of hepatocyte growth factor. Balaban YH, etal., Indian J Gastroenterol. 2006 Jul-Aug;25(4):223-4.
4. Met, metastasis, motility and more. Birchmeier C, etal., Nat Rev Mol Cell Biol. 2003 Dec;4(12):915-25.
5. Active scatter factor (HGF/SF) in proliferative vitreoretinal disease. Briggs MC, etal., Invest Ophthalmol Vis Sci. 2000 Sep;41(10):3085-94.
6. c-MET pathway involvement in chronic rhinosinusitis: a genetic association analysis. Castano R, etal., Otolaryngol Head Neck Surg. 2010 May;142(5):665-71.e1-2. doi: 10.1016/j.otohns.2010.01.004.
7. Hepatocyte growth factor/scatter factor promotes retinal angiogenesis through increased urokinase expression. Colombo ES, etal., Invest Ophthalmol Vis Sci. 2007 Apr;48(4):1793-800.
8. Hepatocyte growth factor activates phosphoinositide 3-kinase C2 beta in renal brush-border plasma membranes. Crljen V, etal., Biochem J 2002 Aug 1;365(Pt 3):791-9.
9. Hepatocyte growth factor incorporated into herpes simplex virus vector accelerates facial nerve regeneration after crush injury. Esaki S, etal., Gene Ther. 2011 Nov;18(11):1063-9. doi: 10.1038/gt.2011.57. Epub 2011 May 12.
10. Differential gene expression of MMP-1, TIMP-1 and HGF in clinically involved and uninvolved skin in South Africans with SSc. Frost J, etal., Rheumatology (Oxford). 2012 Jun;51(6):1049-52. doi: 10.1093/rheumatology/ker367. Epub 2012 Jan 27.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. The Met tyrosine kinase receptor in development and cancer. Gentile A, etal., Cancer Metastasis Rev. 2008 Mar;27(1):85-94.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Family-based association analysis of hepatocyte growth factor (HGF) gene polymorphisms in high myopia. Han W, etal., Invest Ophthalmol Vis Sci. 2006 Jun;47(6):2291-9.
15. Identification of novel cellular targets in biliary tract cancers using global gene expression technology. Hansel DE, etal., Am J Pathol. 2003 Jul;163(1):217-29.
16. Levels of vascular endothelial growth factor and hepatocyte growth factor in sera of patients with rheumatic diseases. Hashimoto N, etal., Mod Rheumatol. 2003 Jun;13(2):129-34. doi: 10.3109/s10165-002-0211-8.
17. Hepatocyte growth factor accelerates the proliferation of hepatic oval cells and possibly promotes the differentiation in a 2-acetylaminofluorene/partial hepatectomy model in rats. Hasuike S, etal., J Gastroenterol Hepatol. 2005 Nov;20(11):1753-61.
18. Intravitreous levels of hepatocyte growth factor/scatter factor and vascular cell adhesion molecule-1 in the vitreous fluid of diabetic patients with proliferative retinopathy. Hernandez C, etal., Diabetes Metab. 2004 Sep;30(4):341-6.
19. Strong association between serum hepatocyte growth factor and metabolic syndrome. Hiratsuka A, etal., J Clin Endocrinol Metab. 2005 May;90(5):2927-31. Epub 2005 Feb 15.
20. Association of hepatocyte growth factor promoter polymorphism with severity of interstitial lung disease in Japanese patients with systemic sclerosis. Hoshino K, etal., Arthritis Rheum. 2011 Aug;63(8):2465-72. doi: 10.1002/art.30415.
21. Differences in the temporal expression of regulatory growth factors during choroidal neovascular development. Hu W, etal., Exp Eye Res. 2009 Jan;88(1):79-91. doi: 10.1016/j.exer.2008.10.014. Epub 2008 Nov 1.
22. Hepatocyte growth factor ameliorates dermal sclerosis in the tight-skin mouse model of scleroderma. Iwasaki T, etal., Arthritis Res Ther. 2006;8(6):R161.
23. Hepatocyte growth factor genetic variations and primary angle-closure glaucoma in the Han Chinese population. Jiang Z, etal., PLoS One. 2013 Apr 9;8(4):e60950. doi: 10.1371/journal.pone.0060950. Print 2013.
24. [Serum hepatocyte growth factor (HGF) in patients with inflammatory myopathies]. Kadoya A, etal., Nihon Rinsho Meneki Gakkai Kaishi. 1996 Oct;19(5):488-97.
25. Hepatocyte growth factor gene therapy slows down the progression of diabetic nephropathy in db/db mice. Kagawa T, etal., Nephron Physiol. 2006;102(3-4):p92-102. Epub 2005 Dec 6.
26. Nonviral gene transfer of human hepatocyte growth factor improves streptozotocin-induced diabetic neuropathy in rats. Kato N, etal., Diabetes. 2005 Mar;54(3):846-54.
27. Reduced high serum hepatocyte growth factor levels after successful cardioversion in patients with atrial fibrillation. Katoh H, etal., Clin Exp Pharmacol Physiol. 2004 Mar;31(3):145-51.
28. Increase in the circulating level of hepatocyte growth factor in pancreatic cancer patients. Kemik O, etal., Bratisl Lek Listy. 2009;110(10):627-9.
29. c-Met expression as an indicator of survival outcome in patients with oral tongue carcinoma. Kim CH, etal., Head Neck. 2010 Dec;32(12):1655-64. doi: 10.1002/hed.21383.
30. Hepatocyte growth factor promotes endogenous repair and functional recovery after spinal cord injury. Kitamura K, etal., J Neurosci Res. 2007 Aug 15;85(11):2332-42.
31. Human hepatocyte growth factor promotes functional recovery in primates after spinal cord injury. Kitamura K, etal., PLoS One. 2011;6(11):e27706. doi: 10.1371/journal.pone.0027706. Epub 2011 Nov 29.
32. Role of fibroblast-derived growth factors in regulating hyperpigmentation of solar lentigo. Kovacs D, etal., Br J Dermatol. 2010 Nov;163(5):1020-7. doi: 10.1111/j.1365-2133.2010.09946.x.
33. Acceleration of wound healing by combined gene transfer of hepatocyte growth factor and prostacyclin synthase with Shima Jet. Kunugiza Y, etal., Gene Ther. 2006 Aug;13(15):1143-52. Epub 2006 Mar 30.
34. Suppression of progressive loss of coat color in microphthalmia-vitiligo mutant mice. Kurita K, etal., J Invest Dermatol. 2005 Sep;125(3):538-44.
35. Hepatocyte growth factor ameliorates acute graft-versus-host disease and promotes hematopoietic function. Kuroiwa T, etal., J Clin Invest. 2001 Jun;107(11):1365-73.
36. Unique epithelial cell production of hepatocyte growth factor/scatter factor by putative precancerous intestinal metaplasias and associated "intestinal-type" biliary cancer chemically induced in rat liver. Lai GH, etal., Hepatology. 2000 Jun;31(6):1257-65.
37. Vascular endothelial growth factor and hepatocyte growth factor levels are differentially elevated in patients with advanced retinopathy of prematurity. Lashkari K, etal., Am J Pathol. 2000 Apr;156(4):1337-44.
38. Hyaluronan mixed esters of butyric and retinoic acid affording myocardial survival and repair without stem cell transplantation. Lionetti V, etal., J Biol Chem. 2010 Mar 26;285(13):9949-61. doi: 10.1074/jbc.M109.087254. Epub 2010 Jan 22.
39. [Tubular epithelial-myofibroblast transdifferentiation and expressions of hepatocyte growth factor and Smad7 in renal tissues of rat with experimental diabetes] Liu QJ, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2005 Nov;17(11):675-8.
40. Neuroprotective effect of hepatocyte growth factor against photoreceptor degeneration in rats. Machida S, etal., Invest Ophthalmol Vis Sci. 2004 Nov;45(11):4174-82.
41. Adenosine administration accelerates progression of the cell cycle during rat liver regeneration induced by one-third hepatectomy. Mendieta-Condado E, etal., J Pharmacol Exp Ther. 2009 Oct;331(1):122-32. Epub 2009 Jul 28.
42. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
43. Angiogenic gene cell therapy using suicide gene system regulates the effect of angiogenesis in infarcted rat heart. Miyagawa S, etal., Transplantation. 2006 Mar 27;81(6):902-7.
44. Safety evaluation of clinical gene therapy using hepatocyte growth factor to treat peripheral arterial disease. Morishita R, etal., Hypertension. 2004 Aug;44(2):203-9. Epub 2004 Jul 6.
45. Association between hepatocyte growth factor gene polymorphism and essential hypertension. Motone M, etal., Hypertens Res. 2004 Apr;27(4):247-51.
46. Comparison of the effects of HGF, BDNF, CT-1, CNTF, and the branchial arches on the growth of embryonic cranial motor neurons. Naeem A, etal., J Neurobiol 2002 May;51(2):101-14.
47. Co-expression of different angiogenic factors in external auditory canal cholesteatoma. Naim R, etal., Acta Otolaryngol. 2004 Jun;124(5):563-8.
48. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
49. A novel nude mouse model of liver metastasis and peritoneal dissemination from the same human pancreatic cancer line. Nishimori H, etal., Pancreas. 2002 Apr;24(3):242-50.
50. Serum hepatocyte growth factor as a possible indicator of arteriosclerosis. Nishimura M, etal., J Hypertens. 1997 Oct;15(10):1137-42.
51. Accelerated ultraviolet radiation-induced carcinogenesis in hepatocyte growth factor/scatter factor transgenic mice. Noonan FP, etal., Cancer Res. 2000 Jul 15;60(14):3738-43.
52. A comparison of the levels of hepatocyte growth factor in serum in patients with type 1 diabetes mellitus with different stages of diabetic retinopathy. Nowak M, etal., Endokrynol Pol. 2008 Jan-Feb;59(1):2-5.
53. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
54. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
55. Involvement of hepatocyte growth factor in the development of bone metastasis of a mouse mammary cancer cell line, BALB/c-MC. Ono K, etal., Bone. 2006 Jul;39(1):27-34. Epub 2006 Feb 3.
56. Intrathecal injection of HVJ-E containing HGF gene to cerebrospinal fluid can prevent and ameliorate hearing impairment in rats. Oshima K, etal., FASEB J. 2004 Jan;18(1):212-4. Epub 2003 Nov 20.
57. c-Met autocrine activation induces development of malignant melanoma and acquisition of the metastatic phenotype. Otsuka T, etal., Cancer Res. 1998 Nov 15;58(22):5157-67.
58. Disassociation of met-mediated biological responses in vivo: the natural hepatocyte growth factor/scatter factor splice variant NK2 antagonizes growth but facilitates metastasis. Otsuka T, etal., Mol Cell Biol. 2000 Mar;20(6):2055-65.
59. Angiogenesis and capillary maturation phenotypes associated with the Edpm3 locus on rat chromosome 3. Pandey J and Wendell DL, Mamm Genome. 2006 Jan;17(1):49-57. Epub 2006 Jan 13.
60. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
61. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
62. Insulin-like growth factor I is a comitogen for hepatocyte growth factor in a rat model of hepatocellular carcinoma. Price JA, etal., Hepatology 2002 Nov;36(5):1089-97.
63. Hepatocyte growth factor and c-MET in benign and malignant peripheral nerve sheath tumors. Rao UN, etal., Hum Pathol. 1997 Sep;28(9):1066-70.
64. Obesity is associated with increased levels of circulating hepatocyte growth factor. Rehman J, etal., J Am Coll Cardiol. 2003 Apr 16;41(8):1408-13.
65. GOA pipeline RGD automated data pipeline
66. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
67. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
68. Overexpression of hepatocyte growth factor and its receptor c-Met in nasal polyps. Rho HS, etal., Arch Otolaryngol Head Neck Surg. 2006 Sep;132(9):985-9.
69. Proteinase and growth factor alterations revealed by gene microarray analysis of human diabetic corneas. Saghizadeh M, etal., Invest Ophthalmol Vis Sci. 2005 Oct;46(10):3604-15.
70. Association of the hepatocyte growth factor gene with keratoconus in an Australian population. Sahebjada S, etal., PLoS One. 2014 Jan 8;9(1):e84067. doi: 10.1371/journal.pone.0084067. eCollection 2014.
71. Aqueous humor levels of hepatocyte growth factor in retinitis pigmentosa. Salom D, etal., Invest Ophthalmol Vis Sci. 2010 Jun;51(6):3157-61. doi: 10.1167/iovs.09-4390. Epub 2010 Jan 6.
72. Clinical significance of circulating hepatocyte growth factor, a new risk marker of carotid atherosclerosis in patients with Type 2 diabetes. Satani K, etal., Diabet Med. 2006 Jun;23(6):617-22.
73. Noncoding mutations of HGF are associated with nonsyndromic hearing loss, DFNB39. Schultz JM, etal., Am J Hum Genet. 2009 Jul;85(1):25-39. doi: 10.1016/j.ajhg.2009.06.003. Epub 2009 Jul 2.
74. Expression and neuroprotective effect of hepatocyte growth factor in retinal ischemia-reperfusion injury. Shibuki H, etal., Invest Ophthalmol Vis Sci. 2002 Feb;43(2):528-36.
75. Serum hepatocyte growth factor predicts ventricular remodeling following myocardial infarction. Soeki T, etal., Circ J. 2002 Nov;66(11):1003-7.
76. Localization and functional role of hepatocyte growth factor (HGF) and its receptor c-met in the rat developing cerebral cortex. Sun W, etal., Brain Res Mol Brain Res 2002 Jun 30;103(1-2):36-48.
77. Skeletal muscle injury induces hepatocyte growth factor expression in spleen. Suzuki S, etal., Biochem Biophys Res Commun 2002 Apr 5;292(3):709-14.
78. Gallbladder cancer treatment using adenovirus expressing the HGF/NK4 gene in a peritoneal implantation model. Tanaka T, etal., Cancer Gene Ther. 2004 Jun;11(6):431-40.
79. Deduced primary structure of rat hepatocyte growth factor and expression of the mRNA in rat tissues. Tashiro K, etal., Proc Natl Acad Sci U S A 1990 Apr;87(8):3200-4.
80. Release of hepatocyte growth factor from mechanically stretched skeletal muscle satellite cells and role of pH and nitric oxide. Tatsumi R, etal., Mol Biol Cell 2002 Aug;13(8):2909-18.
81. Leucine stimulates the secretion of hepatocyte growth factor by hepatic stellate cells. Tomiya T, etal., Biochem Biophys Res Commun 2002 Oct 11;297(5):1108-11.
82. Hepatocyte growth factor protects retinal ganglion cells by increasing neuronal survival and axonal regeneration in vitro and in vivo. Tonges L, etal., J Neurochem. 2011 Jun;117(5):892-903. doi: 10.1111/j.1471-4159.2011.07257.x. Epub 2011 Apr 26.
83. Hepatocyte growth factor in cerebrospinal fluid in neurologic disease. Tsuboi Y, etal., Acta Neurol Scand. 2002 Aug;106(2):99-103.
84. Nonviral retrograde gene transfer of human hepatocyte growth factor improves neuropathic pain-related phenomena in rats. Tsuchihara T, etal., Mol Ther. 2009 Jan;17(1):42-50. doi: 10.1038/mt.2008.214. Epub 2008 Oct 21.
85. Immunolocalization of the hepatocyte growth factor (HGF) system in the rat ovary and the anti-apoptotic effect of HGF in rat ovarian granulosa cells in vitro. Uzumcu M, etal., Reproduction. 2006 Aug;132(2):291-9.
86. Independent amplification of two gene clusters on chromosome 4 in rat endometrial cancer: identification and molecular characterization. Walentinsson A, etal., Cancer Res 2001 Nov 15;61(22):8263-73.
87. A dual-color FISH gene map of the proximal region of rat Chromosome 4 and comparative analysis in human and mouse. Walentinsson A, etal., Mamm Genome 2001 Dec;12(12):900-8.
88. High myopia is not associated with the SNPs in the TGIF, lumican, TGFB1, and HGF genes. Wang P, etal., Invest Ophthalmol Vis Sci. 2009 Apr;50(4):1546-51. doi: 10.1167/iovs.08-2537. Epub 2008 Dec 5.
89. Metabolism of hepatocyte growth factor in the heart in patients with coronary artery disease: implication for coronary arteriosclerosis. Watanabe K, etal., Cardiovasc Drugs Ther. 2001 Mar;15(2):147-53.
90. Hepatocyte growth factor both prevents and ameliorates the symptoms of dermal sclerosis in a mouse model of scleroderma. Wu MH, etal., Gene Ther. 2004 Jan;11(2):170-80.
91. Recombinant human hepatocyte growth factor facilitates biliary transport after hepatocyte transplantation in Eisai hyperbilirubinemic rats. Yamaguchi Y, etal., Dig Dis Sci. 1997 Mar;42(3):522-8.
92. Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19. Yang Y, etal., J Allergy Clin Immunol. 2020 Apr 29. pii: S0091-6749(20)30576-5. doi: 10.1016/j.jaci.2020.04.027.
93. Hepatocyte growth factor and myopia: genetic association analyses in a Caucasian population. Yanovitch T, etal., Mol Vis. 2009 May 20;15:1028-35.
94. [Expression and significances of FSCN1 and HGF in nasal inverted papilloma]. Yuan L, etal., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012 Apr;26(8):339-42.
95. Novel therapeutic strategy for stroke in rats by bone marrow stromal cells and ex vivo HGF gene transfer with HSV-1 vector. Zhao MZ, etal., J Cereb Blood Flow Metab. 2006 Sep;26(9):1176-88. Epub 2006 Jan 18.
Additional References at PubMed
PMID:2146117   PMID:2531289   PMID:7953556   PMID:11061428   PMID:11744165   PMID:11832492   PMID:11839582   PMID:11976737   PMID:12042032   PMID:12127815   PMID:12130561   PMID:12163028  
PMID:12969135   PMID:14517989   PMID:14654226   PMID:15153551   PMID:15287857   PMID:15314156   PMID:15326485   PMID:15336531   PMID:15389661   PMID:15505094   PMID:16097045   PMID:16115399  
PMID:16164627   PMID:16386592   PMID:16410125   PMID:16415345   PMID:16543637   PMID:16549518   PMID:16596271   PMID:16786119   PMID:16880525   PMID:16884699   PMID:17124385   PMID:17204247  
PMID:17242177   PMID:17294746   PMID:17382307   PMID:17383528   PMID:17427161   PMID:17466941   PMID:17471308   PMID:17667812   PMID:17767955   PMID:17804794   PMID:17923118   PMID:17940345  
PMID:17975841   PMID:18031729   PMID:18067924   PMID:18199534   PMID:18351465   PMID:18824844   PMID:18979225   PMID:18988920   PMID:19069655   PMID:19095317   PMID:19292056   PMID:19434765  
PMID:19720831   PMID:19834131   PMID:19946888   PMID:20175208   PMID:20404049   PMID:20466058   PMID:20624990   PMID:20655899   PMID:20814222   PMID:20963849   PMID:21072211   PMID:21075102  
PMID:21134835   PMID:21245381   PMID:21643626   PMID:21843593   PMID:21931759   PMID:22165288   PMID:22245998   PMID:22318499   PMID:22361334   PMID:22661380   PMID:22897854   PMID:23024263  
PMID:23270462   PMID:23273597   PMID:23933910   PMID:23954444   PMID:23994610   PMID:24122166   PMID:24370951   PMID:24490163   PMID:24782653   PMID:24815169   PMID:24840640   PMID:25062485  
PMID:25063067   PMID:25099287   PMID:25277788   PMID:25736907   PMID:25793303   PMID:25862490   PMID:25920966   PMID:26213907   PMID:27036872   PMID:27129877   PMID:27480986   PMID:28279229  
PMID:28844859   PMID:29442198   PMID:29932234   PMID:30816491   PMID:30873677   PMID:31337959   PMID:31411175   PMID:31781338   PMID:32921552   PMID:33670243   PMID:33860459   PMID:36293268  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2418,673,736 - 18,745,582 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl418,677,101 - 18,745,409 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx423,828,584 - 23,896,754 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0419,645,467 - 19,713,646 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0418,026,554 - 18,094,730 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0415,435,460 - 15,505,377 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl415,433,295 - 15,505,362 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0415,408,857 - 15,478,988 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4414,864,357 - 14,932,513 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1414,864,356 - 14,932,513 (-)NCBI
Celera414,212,976 - 14,281,167 (-)NCBICelera
Cytogenetic Map4q12NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38781,699,010 - 81,770,047 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl781,699,010 - 81,770,438 (-)EnsemblGRCh38hg38GRCh38
GRCh37781,328,326 - 81,399,363 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36781,169,380 - 81,237,388 (-)NCBINCBI36Build 36hg18NCBI36
Build 34781,024,867 - 81,044,103NCBI
Celera776,032,788 - 76,100,524 (-)NCBICelera
Cytogenetic Map7q21.11NCBI
HuRef775,935,402 - 76,003,191 (-)NCBIHuRef
CHM1_1781,261,794 - 81,329,511 (-)NCBICHM1_1
T2T-CHM13v2.0782,951,060 - 83,022,099 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2780,663,506 - 80,731,238 (-)NCBI
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39516,758,493 - 16,827,448 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl516,758,493 - 16,825,150 (+)EnsemblGRCm39 Ensembl
GRCm38516,553,495 - 16,619,439 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl516,553,495 - 16,620,152 (+)EnsemblGRCm38mm10GRCm38
MGSCv37516,059,368 - 16,125,257 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36516,065,374 - 16,131,263 (+)NCBIMGSCv36mm8
Celera513,552,002 - 13,617,800 (+)NCBICelera
Cytogenetic Map5A3NCBI
cM Map57.07NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554104,114,778 - 4,182,058 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554104,114,280 - 4,181,953 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan17147,813,354 - 147,884,422 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0773,667,618 - 73,738,960 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1787,325,741 - 87,396,850 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl787,327,798 - 87,397,811 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11821,329,688 - 21,410,257 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1821,332,817 - 21,410,263 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1821,005,145 - 21,082,437 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01821,778,181 - 21,858,827 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1821,778,229 - 21,858,761 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11821,417,964 - 21,495,307 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01820,953,619 - 21,030,809 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01821,607,548 - 21,684,870 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440511863,151,279 - 63,227,083 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936734356,115 - 428,779 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936734354,798 - 428,356 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl998,438,143 - 98,513,564 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1998,437,771 - 98,513,573 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29108,765,929 - 108,841,386 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12167,118,785 - 67,193,506 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2167,120,722 - 67,193,504 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604236,762,736 - 36,834,784 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462473930,236,146 - 30,307,356 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473930,233,589 - 30,307,508 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Hgf
149 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:28
Count of miRNA genes:23
Interacting mature miRNAs:28
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4127716890Rat
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4127716890Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4127716890Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4129494328Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4130372989Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4131934116Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4131934116Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4131934116Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4131934116Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4132584199Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4133250345Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4133250345Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
1358201Gluco12Glucose level QTL121.6adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake (CMO:0000870)4521839229593287Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4994088544463908Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41002490139524530Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat

Related Rat Strains
The following Strains have been annotated to Hgf


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 18 18 5 18 7 9 11
Low 3 37 39 23 14 23 8 8 52 28 26 8
Below cutoff 6 3 22 4


RefSeq Acc Id: ENSRNOT00000009763   ⟹   ENSRNOP00000009764
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl418,677,101 - 18,745,409 (-)Ensembl
Rnor_6.0 Ensembl415,433,295 - 15,505,362 (-)Ensembl
RefSeq Acc Id: NM_017017   ⟹   NP_058713
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.2418,677,101 - 18,745,303 (-)NCBI
Rnor_6.0415,436,662 - 15,505,283 (-)NCBI
Rnor_5.0415,408,857 - 15,478,988 (-)NCBI
RGSC_v3.4414,864,357 - 14,932,513 (-)RGD
Celera414,212,976 - 14,281,167 (-)NCBI
RefSeq Acc Id: XM_006235979   ⟹   XP_006236041
Rat AssemblyChrPosition (strand)Source
mRatBN7.2418,673,736 - 18,745,209 (-)NCBI
Rnor_6.0415,435,460 - 15,505,377 (-)NCBI
Rnor_5.0415,408,857 - 15,478,988 (-)NCBI
RefSeq Acc Id: XM_039107016   ⟹   XP_038962944
Rat AssemblyChrPosition (strand)Source
mRatBN7.2418,673,736 - 18,745,582 (-)NCBI
RefSeq Acc Id: XM_039107017   ⟹   XP_038962945
Rat AssemblyChrPosition (strand)Source
mRatBN7.2418,673,736 - 18,745,582 (-)NCBI
RefSeq Acc Id: XM_039107018   ⟹   XP_038962946
Rat AssemblyChrPosition (strand)Source
mRatBN7.2418,673,736 - 18,745,209 (-)NCBI
RefSeq Acc Id: NP_058713   ⟸   NM_017017
- Peptide Label: preproprotein
- UniProtKB: P17945 (UniProtKB/Swiss-Prot),   A6K5E8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236041   ⟸   XM_006235979
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000009764   ⟸   ENSRNOT00000009763
RefSeq Acc Id: XP_038962945   ⟸   XM_039107017
- Peptide Label: isoform X1
- UniProtKB: P17945 (UniProtKB/Swiss-Prot),   A6K5E8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962944   ⟸   XM_039107016
- Peptide Label: isoform X1
- UniProtKB: P17945 (UniProtKB/Swiss-Prot),   A6K5E8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962946   ⟸   XM_039107018
- Peptide Label: isoform X2
- UniProtKB: A0A8L2Q4D1 (UniProtKB/TrEMBL)
Protein Domains
Apple   Kringle   PAN   Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P17945-F1-model_v2 AlphaFold P17945 1-728 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2794 AgrOrtholog
BioCyc Gene G2FUF-45898 BioCyc
Ensembl Genes ENSRNOG00000007027 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000009764 ENTREZGENE
  ENSRNOP00000009764.3 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009763 ENTREZGENE
  ENSRNOT00000009763.6 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hepatocyte Growth Factor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Hepatocyte_GF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HGF-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pan_app UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24446 UniProtKB/Swiss-Prot
Pfam Kringle UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hgf PhenoGen
PIRSF Hepatocyte_GF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HGF_MST1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KRINGLE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KRINGLE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PAN_AP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00130 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Hairpin loop containing domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57440 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-11-06 Hgf  hepatocyte growth factor    Hepatocyte growth factor (scatter factor)  Name updated 625702 APPROVED
2002-06-10 Hgf  Hepatocyte growth factor (scatter factor)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease upregulated in uterine tumors 70557
gene_expression expressed in uterus 70557