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Gene: Cbl (Casitas B-lineage lymphoma) Mus musculus
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Symbol: Cbl
Name: Casitas B-lineage lymphoma
Description: Exhibits SH3 domain binding activity and ephrin receptor binding activity. Involved in regulation of Rap protein signal transduction and regulation of platelet-derived growth factor receptor-alpha signaling pathway. Localizes to the Golgi apparatus and cilium. Colocalizes with the flotillin complex. Human ortholog(s) of this gene implicated in acute myeloid leukemia; juvenile myelomonocytic leukemia; lung non-small cell carcinoma; and myeloid neoplasm. Is expressed in male reproductive system and urinary system. Orthologous to human CBL (Cbl proto-oncogene); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; epidermal growth factor/neuregulin signaling pathway; erythropoietin signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4732447J05Rik; c-Cbl; casitas B-lineage lymphoma proto-oncogene; Cbl-2; E3 ubiquitin-protein ligase CBL; proto-oncogene c-CBL; RING-type E3 ubiquitin transferase CBL; signal transduction protein CBL
Orthologs:
Homo sapiens (human) : CBL (Cbl proto-oncogene)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cbl (Cbl proto-oncogene)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cbl (Cbl proto-oncogene)
Pan paniscus (bonobo/pygmy chimpanzee) : CBL (Cbl proto-oncogene)
Canis lupus familiaris (dog) : CBL (Cbl proto-oncogene)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cbl (Cbl proto-oncogene)
Sus scrofa (pig) : CBL (Cbl proto-oncogene)
Chlorocebus sabaeus (African green monkey) : CBL (Cbl proto-oncogene)
Heterocephalus glaber (naked mole-rat) : Cbl (Cbl proto-oncogene)
more info ...
Related Pseudogenes: Cbl-ps1   Gm18333   Gm6695   Gm7326  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl944,142,976 - 44,234,049 (-)EnsemblGRCm38mm10GRCm38
GRCm38944,142,976 - 44,234,259 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37943,957,345 - 44,042,129 (-)NCBIGRCm37mm9NCBIm37
MGSCv36943,900,257 - 43,985,041 (-)NCBImm8
Celera941,406,821 - 41,486,735 (-)NCBICelera
Cytogenetic Map9A5.1-A5.2NCBI
cM Map924.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Cbl
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1558608
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.