Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Cbl (Casitas B-lineage lymphoma) Mus musculus
Symbol: Cbl
Name: Casitas B-lineage lymphoma
Description: Exhibits SH3 domain binding activity and ephrin receptor binding activity. Involved in regulation of Rap protein signal transduction and regulation of platelet-derived growth factor receptor-alpha signaling pathway. Localizes to the Golgi apparatus and cilium. Colocalizes with the flotillin complex. Human ortholog(s) of this gene implicated in acute myeloid leukemia; juvenile myelomonocytic leukemia; lung non-small cell carcinoma; and myeloid neoplasm. Is expressed in male reproductive system and urinary system. Orthologous to human CBL (Cbl proto-oncogene); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; epidermal growth factor/neuregulin signaling pathway; erythropoietin signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4732447J05Rik; c-Cbl; casitas B-lineage lymphoma proto-oncogene; Cbl-2; E3 ubiquitin-protein ligase CBL; proto-oncogene c-CBL; RING-type E3 ubiquitin transferase CBL; signal transduction protein CBL
Homo sapiens (human) : CBL (Cbl proto-oncogene)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cbl (Cbl proto-oncogene)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cbl (Cbl proto-oncogene)
Pan paniscus (bonobo/pygmy chimpanzee) : CBL (Cbl proto-oncogene)
Canis lupus familiaris (dog) : CBL (Cbl proto-oncogene)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cbl (Cbl proto-oncogene)
Sus scrofa (pig) : CBL (Cbl proto-oncogene)
Chlorocebus sabaeus (African green monkey) : CBL (Cbl proto-oncogene)
Heterocephalus glaber (naked mole-rat) : Cbl (Cbl proto-oncogene)
more info ...
Related Pseudogenes: Cbl-ps1   Gm18333   Gm6695   Gm7326  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl944,142,976 - 44,234,049 (-)EnsemblGRCm38mm10GRCm38
GRCm38944,142,976 - 44,234,259 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37943,957,345 - 44,042,129 (-)NCBIGRCm37mm9NCBIm37
MGSCv36943,900,257 - 43,985,041 (-)NCBImm8
Celera941,406,821 - 41,486,735 (-)NCBICelera
Cytogenetic Map9A5.1-A5.2NCBI
cM Map924.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Cbl
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1558608
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.