GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Prkca | decreases expression | EXP | | 6480464 | CTD | lead acetate results in decreased expression of PRKCA protein | PMID:16547843 PMID:25981801 | Prkca | increases phosphorylation | EXP | | 6480464 | CTD | lead acetate results in increased phosphorylation of PRKCA protein | PMID:26797587 | Prkca | multiple interactions | EXP | | 6480464 | CTD | [lead acetate results in increased abundance of Lead] which results in decreased expression of and results in decreased phosphorylation of PRKCA protein; [lead acetate results in increased abundance of Lead] which results in decreased expression of PRKCA mRNA; Genistein inhibits the reaction [lead acetate results in increased phosphorylation of PRKCA protein]; Nimodipine inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of and results in decreased phosphorylation of PRKCA protein]; Ro 31-8220 promotes the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of and results in decreased phosphorylation of PRKCA protein]; Tetradecanoylphorbol Acetate inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of and results in decreased phosphorylation of PRKCA protein] | PMID:26797587 PMID:36925031 | Prkca | decreases expression | ISO | PRKCA (Homo sapiens) | 6480464 | CTD | lead acetate results in decreased expression of PRKCA protein | PMID:11861786 | Prkca | increases expression | ISO | Prkca (Mus musculus) | 6480464 | CTD | lead acetate results in increased expression of PRKCA mRNA | PMID:22609695 | Prkca | multiple interactions | ISO | PRKCA (Homo sapiens) | 6480464 | CTD | 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead acetate results in increased activity of PRKCA protein]; [lead acetate results in decreased expression of PRKCA protein] inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [lead acetate results in decreased expression of PRKCA protein] inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; EGFR mutant form inhibits the reaction [lead acetate results in increased activity of PRKCA protein]; lead acetate results in increased activity of and affects the localization of PRKCA protein; PRKCA mutant form inhibits the reaction [lead acetate results in increased activity of HRAS protein]; SU 6656 inhibits the reaction [lead acetate results in increased activity of PRKCA protein] | PMID:11861786 PMID:19133285 | | ||||||||||||||||||||||
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