Enables coreceptor activity and protease binding activity. Involved in several processes, including positive regulation of cell migration; positive regulation of transport; and regulation of neuron projection development. Located in several cellular components, including axonal growth cone; cytoplasmic vesicle; and neuronal cell body. Used to study diabetes mellitus. Biomarker of Alzheimer's disease; prostate carcinoma in situ; and sciatic neuropathy. Human ortholog(s) of this gene implicated in Alzheimer's disease; keratosis pilaris atrophicans; myocardial infarction; and sciatic neuropathy. Orthologous to human LRP1 (LDL receptor related protein 1); PARTICIPATES IN platelet-derived growth factor signaling pathway; Alzheimer's disease pathway; malaria pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
LOC299858; low density lipoprotein receptor-related protein 1; low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor); LRP-1; prolow-density lipoprotein receptor-related protein 1
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of LRP1 mRNA more ...
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of LRP1 mRNA
[bisphenol A co-treated with Fulvestrant] results in increased methylation of LRP1 gene, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of LRP1 mRNA
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of LRP1 mRNA
[Capsaicin results in decreased expression of LRP1 protein] which results in decreased uptake of Cholesterol, [Capsaicin results in decreased expression of LRP1 protein] which results in increased secretion of Cholesterol
[Cisplatin co-treated with jinfukang] results in increased expression of LRP1 mRNA, tanshinone inhibits the reaction [Cisplatin results in increased expression of LRP1 mRNA]
[Clofibrate co-treated with Acetaminophen] affects the expression of LRP1 mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of LRP1 mRNA]
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of LRP1 mRNA more ...
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of LRP1 mRNA more ...
[lead acetate results in increased abundance of Lead] which results in decreased expression of LRP1 mRNA, [lead acetate results in increased abundance of Lead] which results in decreased expression of LRP1 protein
[lead acetate results in increased abundance of Lead] which results in decreased expression of LRP1 mRNA, [lead acetate results in increased abundance of Lead] which results in decreased expression of LRP1 protein
[lead acetate results in increased abundance of Lead] which results in decreased expression of LRP1 mRNA, [lead acetate results in increased abundance of Lead] which results in decreased expression of LRP1 protein
[Clofibrate co-treated with Acetaminophen] affects the expression of LRP1 mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of LRP1 mRNA]
[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of LRP1 mRNA, [perfluorooctane sulfonic acid co-treated with Pectins] results in decreased expression of LRP1 mRNA
Tetradecanoylphorbol Acetate results in increased expression of LRP1 mRNA, Tetradecanoylphorbol Acetate results in increased expression of LRP1 protein
[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of LRP1 mRNA, [Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of LRP1 mRNA
SB 203580 inhibits the reaction [tanshinone results in decreased expression of LRP1 mRNA], tanshinone inhibits the reaction [Cisplatin results in increased expression of LRP1 mRNA]
Low density lipoprotein receptor-related protein is expressed early and becomes restricted to a somatodendritic domain during neuronal differentiation in culture.
Low-density lipoprotein receptor-related protein 1 mediates hypoxia-induced very low density lipoprotein-cholesteryl ester uptake and accumulation in cardiomyocytes.
Decreased hepatic expression of the low-density lipoprotein (LDL) receptor and LDL receptor-related protein in aging rats is associated with delayed clearance of chylomicrons from the circulation.
A potential neuroprotective role of apolipoprotein E-containing lipoproteins through low density lipoprotein receptor-related protein 1 in normal tension glaucoma.
Tissue-type plasminogen activator acts as a cytokine that triggers intracellular signal transduction and induces matrix metalloproteinase-9 gene expression.
Effect of Linguizhugan decoction on neuroinflammation and expression disorder of the amyloid ß-related transporters RAGE and LRP-1 in a rat model of Alzheimer's disease.
Angiotensin II-induced smooth muscle cell migration is mediated by LDL receptor-related protein 1 via regulation of matrix metalloproteinase 2 expression.
Murine low-density lipoprotein receptor-related protein 1 (LRP) is required for phagocytosis of targets bearing LRP ligands but is not required for C1q-triggered enhancement of phagocytosis.
Uptake of HIV-1 tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands.
The functional role of the second NPXY motif of the LRP1 beta-chain in tissue-type plasminogen activator-mediated activation of N-methyl-D-aspartate receptors.
Large scale association analysis for identification of genes underlying premature coronary heart disease: cumulative perspective from analysis of 111 candidate genes.
Plasminogen activator inhibitor-1 and vitronectin promote the cellular clearance of thrombin by low density lipoprotein receptor-related proteins 1 and 2.
LDL receptor-related protein-1 is a sialic-acid-independent receptor for myelin-associated glycoprotein that functions in neurite outgrowth inhibition by MAG and CNS myelin.
Endocytosis of hepatic lipase and lipoprotein lipase into rat liver hepatocytes in vivo is mediated by the low density lipoprotein receptor-related protein.
