Lrp1 (LDL receptor related protein 1) - Rat Genome Database

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Gene: Lrp1 (LDL receptor related protein 1) Rattus norvegicus
Analyze
Symbol: Lrp1
Name: LDL receptor related protein 1
RGD ID: 1307535
Description: Enables coreceptor activity and protease binding activity. Involved in several processes, including positive regulation of cell migration; positive regulation of transport; and regulation of neuron projection development. Located in several cellular components, including axonal growth cone; cytoplasmic vesicle; and neuronal cell body. Used to study diabetes mellitus. Biomarker of Alzheimer's disease; prostate carcinoma in situ; and sciatic neuropathy. Human ortholog(s) of this gene implicated in Alzheimer's disease; keratosis pilaris atrophicans; myocardial infarction; and sciatic neuropathy. Orthologous to human LRP1 (LDL receptor related protein 1); PARTICIPATES IN platelet-derived growth factor signaling pathway; Alzheimer's disease pathway; malaria pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC299858; low density lipoprotein receptor-related protein 1; low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor); LRP-1; prolow-density lipoprotein receptor-related protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8765,265,639 - 65,346,196 (-)NCBIGRCr8
mRatBN7.2763,380,325 - 63,461,029 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl763,380,356 - 63,460,910 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx765,269,622 - 65,350,191 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0767,472,045 - 67,552,607 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0767,273,181 - 67,353,771 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0770,846,313 - 70,927,028 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,846,344 - 70,926,903 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0771,018,808 - 71,099,367 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4767,520,575 - 67,601,549 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1767,541,343 - 67,622,669 (-)NCBI
Celera760,519,175 - 60,599,687 (-)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-tert-butylphenol  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
alpha-D-galactose  (ISO)
amitrole  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
BAPTA  (ISO)
benzo[a]pyrene  (ISO)
bilirubin IXalpha  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
Brodifacoum  (EXP)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
cholesterol  (ISO)
ciguatoxin CTX1B  (ISO)
cimetidine  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
clotrimazole  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diiodine  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
emodin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
fenthion  (ISO)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
galactose  (ISO)
gentamycin  (EXP)
glutathione  (EXP)
hydrogen peroxide  (ISO)
hypochlorous acid  (ISO)
imatinib methanesulfonate  (EXP)
indometacin  (ISO)
ivermectin  (ISO)
KT 5720  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
lucanthone  (ISO)
melatonin  (EXP)
menadione  (ISO)
methamphetamine  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
miconazole  (ISO)
microcystin-LR  (ISO)
monosodium L-glutamate  (ISO)
morphine  (ISO)
Muraglitazar  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
nefazodone  (EXP)
niclosamide  (ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
propiconazole  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 203580  (ISO)
senecionine  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
Tanshinone I  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triprolidine  (ISO)
triptonide  (ISO)
valproic acid  (EXP,ISO)
very-low-density lipoprotein triglyceride  (ISO)
vinclozolin  (EXP)
warfarin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid-beta clearance  (ISO)
amyloid-beta clearance by cellular catabolic process  (IBA,IEA,ISO)
amyloid-beta clearance by transcytosis  (IBA,IEA,ISO)
aorta morphogenesis  (ISO)
apoptotic cell clearance  (ISO)
astrocyte activation involved in immune response  (ISO)
cardiac septum development  (ISO)
cellular lipid catabolic process  (IMP)
cellular response to amyloid-beta  (ISO)
cerebral cortex development  (IEP)
chemoattraction of axon  (IMP)
cholesterol metabolic process  (ISO)
coronary vasculature development  (ISO)
enzyme-linked receptor protein signaling pathway  (ISO)
lysosomal transport  (ISO)
negative regulation of apoptotic process  (IMP)
negative regulation of cell-substrate adhesion  (IMP)
negative regulation of cytosolic calcium ion concentration  (IMP)
negative regulation of focal adhesion assembly  (IMP)
negative regulation of gene expression  (ISO)
negative regulation of neuron apoptotic process  (IDA,IMP)
negative regulation of neuron projection development  (IMP)
negative regulation of platelet-derived growth factor receptor-beta signaling pathway  (ISO)
negative regulation of SMAD protein signal transduction  (ISO)
negative regulation of smooth muscle cell migration  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
negative regulation of Wnt signaling pathway  (ISO)
phagocytosis  (IBA,IEA,ISO)
positive regulation of amyloid-beta clearance  (ISO)
positive regulation of axon extension  (IMP)
positive regulation of axon extension involved in regeneration  (IDA)
positive regulation of chemokine (C-X-C motif) ligand 2 production  (IMP)
positive regulation of cholesterol efflux  (ISO)
positive regulation of cholesterol import  (IMP)
positive regulation of cholesterol transport  (ISO)
positive regulation of collateral sprouting of injured axon  (IDA)
positive regulation of cytosolic calcium ion concentration  (IMP)
positive regulation of endocytosis  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IMP)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (IMP)
positive regulation of lipid transport  (ISO)
positive regulation of lysosomal protein catabolic process  (IEA,ISO)
positive regulation of neuron projection development  (IMP)
positive regulation of phagocytosis  (IMP)
positive regulation of protein localization to plasma membrane  (IEA,ISO)
positive regulation of protein transport  (IMP)
positive regulation of Schwann cell migration  (IMP)
positive regulation of transcytosis  (ISO)
positive regulation of vascular associated smooth muscle cell migration  (IMP)
protein kinase C-activating G protein-coupled receptor signaling pathway  (IMP)
receptor internalization  (ISO)
receptor-mediated endocytosis  (IBA,IEA,IMP,ISO)
regulation of actin cytoskeleton organization  (ISO)
regulation of cholesterol transport  (ISO)
regulation of postsynaptic neurotransmitter receptor internalization  (ISO)
regulation of pulmonary blood vessel remodeling  (ISO)
transport across blood-brain barrier  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Collagenase-3 binds to a specific receptor and requires the low density lipoprotein receptor-related protein for internalization. Barmina OY, etal., J Biol Chem. 1999 Oct 15;274(42):30087-93.
2. Lead-induced accumulation of beta-amyloid in the choroid plexus: role of low density lipoprotein receptor protein-1 and protein kinase C. Behl M, etal., Neurotoxicology. 2010 Sep;31(5):524-32. doi: 10.1016/j.neuro.2010.05.004. Epub 2010 May 19.
3. Low density lipoprotein receptor-related protein is expressed early and becomes restricted to a somatodendritic domain during neuronal differentiation in culture. Brown MD, etal., Brain Res. 1997 Feb 7;747(2):313-7.
4. Low-density lipoprotein receptor-related protein 1 mediates hypoxia-induced very low density lipoprotein-cholesteryl ester uptake and accumulation in cardiomyocytes. Cal R, etal., Cardiovasc Res. 2012 Jun 1;94(3):469-79. doi: 10.1093/cvr/cvs136. Epub 2012 Mar 27.
5. The low-density lipoprotein receptor-related protein is a pro-survival receptor in Schwann cells: possible implications in peripheral nerve injury. Campana WM, etal., J Neurosci. 2006 Oct 25;26(43):11197-207. doi: 10.1523/JNEUROSCI.2709-06.2006.
6. Hepatic low-density lipoprotein receptor-related protein deficiency in mice increases atherosclerosis independent of plasma cholesterol. Espirito Santo SM, etal., Blood. 2004 May 15;103(10):3777-82. Epub 2004 Jan 22.
7. Decreased hepatic expression of the low-density lipoprotein (LDL) receptor and LDL receptor-related protein in aging rats is associated with delayed clearance of chylomicrons from the circulation. Field PA and Gibbons GF, Metabolism. 2000 Apr;49(4):492-8.
8. Imatinib mesylate stimulates low-density lipoprotein receptor-related protein 1-mediated ERK phosphorylation in insulin-producing cells. Fred RG, etal., Clin Sci (Lond). 2015 Jan;128(1):17-28. doi: 10.1042/CS20130560.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Low-density lipoprotein receptor-related protein 1 is an essential receptor for myelin phagocytosis. Gaultier A, etal., J Cell Sci. 2009 Apr 15;122(Pt 8):1155-62. doi: 10.1242/jcs.040717. Epub 2009 Mar 19.
11. A shed form of LDL receptor-related protein-1 regulates peripheral nerve injury and neuropathic pain in rodents. Gaultier A, etal., J Clin Invest. 2008 Jan;118(1):161-72. doi: 10.1172/JCI32371.
12. Decreased expression of the low-density lipoprotein receptor-related protein-1 (LRP-1) in rats with prostate cancer. Gilardoni MB, etal., J Histochem Cytochem. 2003 Dec;51(12):1575-80.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. The low-density lipoprotein receptor-related protein 1 is a mitogenic receptor for lactoferrin in osteoblastic cells. Grey A, etal., Mol Endocrinol. 2004 Sep;18(9):2268-78. Epub 2004 Jun 3.
15. Sorting of major cargo glycoproteins into clathrin-coated vesicles. Harasaki K, etal., Traffic. 2005 Nov;6(11):1014-26.
16. A potential neuroprotective role of apolipoprotein E-containing lipoproteins through low density lipoprotein receptor-related protein 1 in normal tension glaucoma. Hayashi H, etal., J Biol Chem. 2012 Jul 20;287(30):25395-406. doi: 10.1074/jbc.M112.370130. Epub 2012 Jun 6.
17. Apolipoprotein E-containing lipoproteins protect neurons from apoptosis via a signaling pathway involving low-density lipoprotein receptor-related protein-1. Hayashi H, etal., J Neurosci. 2007 Feb 21;27(8):1933-41.
18. Tissue-type plasminogen activator acts as a cytokine that triggers intracellular signal transduction and induces matrix metalloproteinase-9 gene expression. Hu K, etal., J Biol Chem. 2006 Jan 27;281(4):2120-7. Epub 2005 Nov 22.
19. Tissue-type plasminogen activator promotes murine myofibroblast activation through LDL receptor-related protein 1-mediated integrin signaling. Hu K, etal., J Clin Invest. 2007 Dec;117(12):3821-32.
20. Effect of Linguizhugan decoction on neuroinflammation and expression disorder of the amyloid ß-related transporters RAGE and LRP-1 in a rat model of Alzheimer's disease. Hu Q, etal., Mol Med Rep. 2018 Jan;17(1):827-834. doi: 10.3892/mmr.2017.7983. Epub 2017 Nov 6.
21. Role of LRP1 and ERK and cAMP Signaling Pathways in Lactoferrin-Induced Lipolysis in Mature Rat Adipocytes. Ikoma-Seki K, etal., PLoS One. 2015 Oct 27;10(10):e0141378. doi: 10.1371/journal.pone.0141378. eCollection 2015.
22. Neurite-promoting effect of alpha 2-macroglobulin in rat cerebral cortex is mainly associated with alpha 2-macroglobulin receptor. Ishii M, etal., Brain Res. 1996 Oct 21;737(1-2):269-74.
23. Proteomic analysis of GLUT4 storage vesicles reveals LRP1 to be an important vesicle component and target of insulin signaling. Jedrychowski MP, etal., J Biol Chem. 2010 Jan 1;285(1):104-14. doi: 10.1074/jbc.M109.040428. Epub 2009 Oct 28.
24. Angiotensin II-induced smooth muscle cell migration is mediated by LDL receptor-related protein 1 via regulation of matrix metalloproteinase 2 expression. Jung HO, etal., Biochem Biophys Res Commun. 2010 Nov 26;402(4):577-82. doi: 10.1016/j.bbrc.2010.10.019. Epub 2010 Oct 19.
25. Tissue-type plasminogen activator suppresses activated stellate cells through low-density lipoprotein receptor-related protein 1. Kang LI, etal., Lab Invest. 2015 Oct;95(10):1117-29. doi: 10.1038/labinvest.2015.94. Epub 2015 Aug 3.
26. Association at LRP gene locus with sporadic late-onset Alzheimer's disease. Lambert JC, etal., Lancet 1998 Jun 13;351(9118):1787-8.
27. Low-density Lipoprotein Receptor-related Proteins in a Novel Mechanism of Axon Guidance and Peripheral Nerve Regeneration. Landowski LM, etal., J Biol Chem. 2016 Jan 15;291(3):1092-102. doi: 10.1074/jbc.M115.668996. Epub 2015 Nov 23.
28. Murine low-density lipoprotein receptor-related protein 1 (LRP) is required for phagocytosis of targets bearing LRP ligands but is not required for C1q-triggered enhancement of phagocytosis. Lillis AP, etal., J Immunol. 2008 Jul 1;181(1):364-73. doi: 10.4049/jimmunol.181.1.364.
29. Uptake of HIV-1 tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands. Liu Y, etal., Nat Med. 2000 Dec;6(12):1380-7.
30. Altered expression of Abeta metabolism-associated molecules from D-galactose/AlCl(3) induced mouse brain. Luo Y, etal., Mech Ageing Dev. 2009 Apr;130(4):248-52. doi: 10.1016/j.mad.2008.12.005. Epub 2008 Dec 27.
31. Low density lipoprotein receptor-related protein (LRP1) regulates Rac1 and RhoA reciprocally to control Schwann cell adhesion and migration. Mantuano E, etal., J Biol Chem. 2010 May 7;285(19):14259-66. doi: 10.1074/jbc.M109.085126. Epub 2010 Mar 2.
32. The functional role of the second NPXY motif of the LRP1 beta-chain in tissue-type plasminogen activator-mediated activation of N-methyl-D-aspartate receptors. Martin AM, etal., J Biol Chem. 2008 May 2;283(18):12004-13. doi: 10.1074/jbc.M707607200. Epub 2008 Mar 5.
33. Involvement of low-density lipoprotein receptor-related protein and ABCG1 in stimulation of axonal extension by apoE-containing lipoproteins. Matsuo M, etal., Biochim Biophys Acta. 2011 Jan;1811(1):31-8. Epub 2010 Oct 30.
34. Neuronal LRP1 functionally associates with postsynaptic proteins and is required for normal motor function in mice. May P, etal., Mol Cell Biol 2004 Oct;24(20):8872-83.
35. Large scale association analysis for identification of genes underlying premature coronary heart disease: cumulative perspective from analysis of 111 candidate genes. McCarthy JJ, etal., J Med Genet. 2004 May;41(5):334-41.
36. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
37. Upregulation of hepatic LRP1 by rosiglitazone: a possible novel mechanism of the beneficial effect of thiazolidinediones on atherogenic dyslipidemia. Moon JH, etal., J Mol Endocrinol. 2012 Oct 10;49(3):165-74. doi: 10.1530/JME-12-0119. Print 2012 Dec.
38. Deletion of macrophage LDL receptor-related protein increases atherogenesis in the mouse. Overton CD, etal., Circ Res. 2007 Mar 16;100(5):670-7. Epub 2007 Feb 15.
39. LRP1 controls biosynthetic and endocytic trafficking of neuronal prion protein. Parkyn CJ, etal., J Cell Sci. 2008 Mar 15;121(Pt 6):773-83. doi: 10.1242/jcs.021816. Epub 2008 Feb 19.
40. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
41. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
42. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
43. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
44. Low-density lipoprotein receptor-related protein-1 (LRP-1) expression in a rat model of oxygen-induced retinal neovascularization. Sanchez MC, etal., Exp Eye Res. 2006 Dec;83(6):1378-85. Epub 2006 Sep 15.
45. The LDL receptor-related protein (LRP1/A2MR) and coronary atherosclerosis--novel genomic variants and functional consequences. Schulz S, etal., Hum Mutat. 2002 Nov;20(5):404.
46. Regulation of cytokine expression by Schwann cells in response to a2-macroglobulin binding to LRP1. Shi Y, etal., J Neurosci Res. 2011 Apr;89(4):544-51. doi: 10.1002/jnr.22576. Epub 2011 Feb 2.
47. Plasminogen activator inhibitor-1 and vitronectin promote the cellular clearance of thrombin by low density lipoprotein receptor-related proteins 1 and 2. Stefansson S, etal., J Biol Chem. 1996 Apr 5;271(14):8215-20.
48. LDL receptor-related protein-1 is a sialic-acid-independent receptor for myelin-associated glycoprotein that functions in neurite outgrowth inhibition by MAG and CNS myelin. Stiles TL, etal., J Cell Sci. 2013 Jan 1;126(Pt 1):209-20. doi: 10.1242/jcs.113191. Epub 2012 Nov 6.
49. Characterization of an amyloid precursor protein-binding protein Fe65L2 and its novel isoforms lacking phosphotyrosine-interaction domains. Tanahashi H and Tabira T, Biochem J. 2002 Nov 1;367(Pt 3):687-95. doi: 10.1042/BJ20020562.
50. Endocytosis of hepatic lipase and lipoprotein lipase into rat liver hepatocytes in vivo is mediated by the low density lipoprotein receptor-related protein. Verges M, etal., J Biol Chem. 2004 Mar 5;279(10):9030-6. Epub 2003 Dec 29.
51. Hippocampal NMDAR-Wnt-Catenin signaling disrupted with cognitive deficits in adolescent offspring exposed to prenatal hypoxia. Wei B, etal., Brain Res. 2016 Jan 15;1631:157-64. doi: 10.1016/j.brainres.2015.11.041. Epub 2015 Dec 2.
52. Low-density lipoprotein receptor related protein-1 (LRP1)-dependent cell signaling promotes neurotrophic activity in embryonic sensory neurons. Yamauchi K, etal., PLoS One. 2013 Sep 23;8(9):e75497. doi: 10.1371/journal.pone.0075497. eCollection 2013.
53. Low-density lipoprotein receptor-related protein 1 (LRP1)-dependent cell signaling promotes axonal regeneration. Yoon C, etal., J Biol Chem. 2013 Sep 13;288(37):26557-68. doi: 10.1074/jbc.M113.478552. Epub 2013 Jul 18.
54. Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance. Zhao Z, etal., Nat Neurosci. 2015 Jul;18(7):978-87. doi: 10.1038/nn.4025. Epub 2015 May 25.
Additional References at PubMed
PMID:2779654   PMID:3266596   PMID:12477932   PMID:15082773   PMID:15647754   PMID:16207730   PMID:16445910   PMID:16489109   PMID:16929031   PMID:17012232   PMID:17897319   PMID:17920016  
PMID:17963731   PMID:18281370   PMID:18635818   PMID:18940800   PMID:19047013   PMID:19098903   PMID:19299737   PMID:19501112   PMID:19718435   PMID:19742316   PMID:20630619   PMID:21289173  
PMID:21423176   PMID:21585370   PMID:21703209   PMID:21795536   PMID:21940431   PMID:22658674   PMID:23152628   PMID:23192564   PMID:23382219   PMID:23386614   PMID:23812296   PMID:24129569  
PMID:24305823   PMID:25218173   PMID:25807483   PMID:26142438   PMID:26370502   PMID:26619118   PMID:26781079   PMID:30649678   PMID:30703614   PMID:31350035   PMID:32788217   PMID:35446172  
PMID:35930096   PMID:36372121  


Genomics

Comparative Map Data
Lrp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8765,265,639 - 65,346,196 (-)NCBIGRCr8
mRatBN7.2763,380,325 - 63,461,029 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl763,380,356 - 63,460,910 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx765,269,622 - 65,350,191 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0767,472,045 - 67,552,607 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0767,273,181 - 67,353,771 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0770,846,313 - 70,927,028 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,846,344 - 70,926,903 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0771,018,808 - 71,099,367 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4767,520,575 - 67,601,549 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1767,541,343 - 67,622,669 (-)NCBI
Celera760,519,175 - 60,599,687 (-)NCBICelera
Cytogenetic Map7q22NCBI
LRP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381257,128,483 - 57,213,361 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1257,128,483 - 57,213,361 (+)EnsemblGRCh38hg38GRCh38
GRCh371257,522,266 - 57,607,144 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361255,808,549 - 55,893,409 (+)NCBINCBI36Build 36hg18NCBI36
Build 341255,808,548 - 55,893,390NCBI
Celera1257,176,220 - 57,261,424 (+)NCBICelera
Cytogenetic Map12q13.3NCBI
HuRef1254,560,642 - 54,624,427 (+)NCBIHuRef
HuRef1254,625,579 - 54,646,229 (+)NCBIHuRef
CHM1_11257,489,966 - 57,575,252 (+)NCBICHM1_1
T2T-CHM13v2.01257,096,318 - 57,181,610 (+)NCBIT2T-CHM13v2.0
Lrp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910127,374,026 - 127,457,158 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10127,374,030 - 127,457,017 (-)EnsemblGRCm39 Ensembl
GRCm3810127,538,157 - 127,621,148 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,538,161 - 127,621,148 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710126,975,213 - 127,058,204 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610126,941,137 - 127,024,078 (-)NCBIMGSCv36mm8
Celera10129,930,007 - 130,012,542 (-)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1074.52NCBI
Lrp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554584,861,431 - 4,941,146 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554584,861,431 - 4,941,939 (+)NCBIChiLan1.0ChiLan1.0
LRP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21037,128,926 - 37,215,816 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11237,124,986 - 37,210,395 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01231,713,938 - 31,799,287 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11231,966,149 - 32,051,979 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1231,966,149 - 32,051,979 (-)Ensemblpanpan1.1panPan2
LRP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1101,260,256 - 1,341,705 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl101,260,719 - 1,352,271 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha101,324,330 - 1,405,506 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0101,270,934 - 1,352,176 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl101,270,727 - 1,352,186 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1101,247,639 - 1,328,819 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0101,489,631 - 1,570,787 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0101,614,746 - 1,695,694 (+)NCBIUU_Cfam_GSD_1.0
Lrp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494557,463,638 - 57,543,337 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366461,327,374 - 1,406,456 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366461,326,900 - 1,407,236 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1522,435,636 - 22,519,276 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2524,186,409 - 24,202,094 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11153,039,147 - 53,125,041 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1153,039,364 - 53,125,776 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037192,847,266 - 192,933,317 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480210,734,263 - 10,812,763 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480210,734,907 - 10,812,888 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lrp1
256 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:212
Count of miRNA genes:155
Interacting mature miRNAs:171
Transcripts:ENSRNOT00000031005
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72673740163902784Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73429328279293282Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73429328279293282Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73796056982960569Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74725178365728867Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)759238038104238038Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)761074194106074194Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)762004452101773158Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)762004452101773158Rat

Markers in Region
RH132158  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2763,380,516 - 63,380,721 (+)MAPPERmRatBN7.2
Rnor_6.0770,846,505 - 70,846,709NCBIRnor6.0
Rnor_5.0771,018,969 - 71,019,173UniSTSRnor5.0
RGSC_v3.4767,520,775 - 67,520,979UniSTSRGSC3.4
Celera760,519,336 - 60,519,540UniSTS
Cytogenetic Map7q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 41 56 41 18 41 8 10 74 29 40 11 8
Low 1 2 1 1 1 6 1
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000031005   ⟹   ENSRNOP00000034210
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl763,380,356 - 63,460,910 (-)Ensembl
Rnor_6.0 Ensembl770,846,344 - 70,926,903 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000108298   ⟹   ENSRNOP00000085719
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl763,380,356 - 63,460,910 (-)Ensembl
RefSeq Acc Id: NM_001130490   ⟹   NP_001123962
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8765,265,639 - 65,346,196 (-)NCBI
mRatBN7.2763,380,356 - 63,460,910 (-)NCBI
Rnor_6.0770,846,344 - 70,926,903 (-)NCBI
Rnor_5.0771,018,808 - 71,099,367 (-)NCBI
Celera760,519,175 - 60,599,687 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008765393   ⟹   XP_008763615
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8765,266,235 - 65,345,916 (-)NCBI
mRatBN7.2763,380,325 - 63,461,029 (-)NCBI
Rnor_6.0770,846,313 - 70,927,028 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001123962   ⟸   NM_001130490
- Peptide Label: precursor
- UniProtKB: Q5I0H1 (UniProtKB/Swiss-Prot),   G3V928 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008763615   ⟸   XM_008765393
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A0U0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000034210   ⟸   ENSRNOT00000031005
RefSeq Acc Id: ENSRNOP00000085719   ⟸   ENSRNOT00000108298
Protein Domains
EGF-like   LDL-receptor class A

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695265
Promoter ID:EPDNEW_R5789
Type:initiation region
Name:Lrp1_1
Description:LDL receptor related protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0770,926,843 - 70,926,903EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307535 AgrOrtholog
BioCyc Gene G2FUF-33734 BioCyc
Ensembl Genes ENSRNOG00000025053 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055026725 UniProtKB/Swiss-Prot
  ENSRNOG00060009000 UniProtKB/Swiss-Prot
  ENSRNOG00065016589 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000031005 ENTREZGENE
  ENSRNOT00000031005.6 UniProtKB/Swiss-Prot
  ENSRNOT00000108298.1 UniProtKB/TrEMBL
  ENSRNOT00055046227 UniProtKB/Swiss-Prot
  ENSRNOT00060015110 UniProtKB/Swiss-Prot
  ENSRNOT00065027660 UniProtKB/Swiss-Prot
Gene3D-CATH 2.120.10.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type module UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7365242 IMAGE-MGC_LOAD
InterPro 6-blade_b-propeller_TolB-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cEGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF5050 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLR_classB_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOTCH1_EGF-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:299858 UniProtKB/Swiss-Prot
MGC_CLONE MGC:109576 IMAGE-MGC_LOAD
NCBI Gene 299858 ENTREZGENE
PANTHER LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam cEGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF5050 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FXa_inhibition UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ldl_recept_a UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ldl_recept_b UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lrp1 PhenoGen
PRINTS LDLRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025053 RatGTEx
  ENSRNOG00055026725 RatGTEx
  ENSRNOG00060009000 RatGTEx
  ENSRNOG00065016589 RatGTEx
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00135 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57424 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  YWTD domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A0U0 ENTREZGENE, UniProtKB/TrEMBL
  G3V928 ENTREZGENE, UniProtKB/Swiss-Prot
  Q5I0H1 ENTREZGENE
UniProt Secondary Q5I0H1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-21 Lrp1  LDL receptor related protein 1  Lrp1  low density lipoprotein receptor-related protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Lrp1  low density lipoprotein receptor-related protein 1  Lrp1  low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Lrp1  low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)  Lrp1  low density lipoprotein receptor-related protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Lrp1  low density lipoprotein receptor-related protein 1  Lrp1_predicted  low density lipoprotein receptor-related protein 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Lrp1_predicted  low density lipoprotein receptor-related protein 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED