Lrp1 (LDL receptor related protein 1) - Rat Genome Database

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Gene: Lrp1 (LDL receptor related protein 1) Rattus norvegicus
Analyze
Symbol: Lrp1
Name: LDL receptor related protein 1
RGD ID: 1307535
Description: Enables coreceptor activity and protease binding activity. Involved in several processes, including positive regulation of transport; regulation of cytosolic calcium ion concentration; and regulation of neuron projection development. Located in several cellular components, including axonal growth cone; cytoplasmic vesicle; and neuronal cell body. Used to study diabetes mellitus. Biomarker of Alzheimer's disease; prostate carcinoma in situ; and sciatic neuropathy. Human ortholog(s) of this gene implicated in Alzheimer's disease; keratosis pilaris atrophicans; myocardial infarction; and sciatic neuropathy. Orthologous to human LRP1 (LDL receptor related protein 1); PARTICIPATES IN platelet-derived growth factor signaling pathway; Alzheimer's disease pathway; malaria pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC299858; low density lipoprotein receptor-related protein 1; low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor); LRP-1; prolow-density lipoprotein receptor-related protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2763,380,325 - 63,461,029 (-)NCBI
Rnor_6.0 Ensembl770,846,344 - 70,926,903 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0770,846,313 - 70,927,028 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0771,018,808 - 71,099,367 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4767,520,575 - 67,601,549 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1767,541,343 - 67,622,669 (-)NCBI
Celera760,519,175 - 60,599,687 (-)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-tert-butylphenol  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
alpha-D-galactose  (ISO)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
atrazine  (ISO)
BAPTA  (ISO)
benzo[a]pyrene  (ISO)
bilirubin IXalpha  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
cholesterol  (ISO)
ciguatoxin CTX1B  (ISO)
cimetidine  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
emodin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
galactose  (ISO)
glutathione  (EXP)
hydrogen peroxide  (ISO)
hypochlorous acid  (ISO)
indometacin  (ISO)
KT 5720  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lipopolysaccharide  (ISO)
lucanthone  (ISO)
melatonin  (EXP)
menadione  (ISO)
methamphetamine  (ISO)
miconazole  (ISO)
microcystin-LR  (ISO)
monosodium L-glutamate  (ISO)
morphine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nefazodone  (EXP)
p-toluidine  (EXP)
paracetamol  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
propiconazole  (ISO)
resveratrol  (ISO)
SB 203580  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
succimer  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
Tanshinone I  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triprolidine  (ISO)
triptonide  (ISO)
valproic acid  (EXP,ISO)
very-low-density lipoprotein triglyceride  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (IEP)
amyloid-beta clearance  (ISO)
amyloid-beta clearance by cellular catabolic process  (ISO)
amyloid-beta clearance by transcytosis  (ISO)
aorta morphogenesis  (ISO)
apoptotic cell clearance  (ISO)
astrocyte activation involved in immune response  (ISO)
cardiac septum development  (ISO)
cell population proliferation  (IMP)
cellular lipid catabolic process  (IMP)
cellular response to amyloid-beta  (ISO)
cerebral cortex development  (IEP)
chemoattraction of axon  (IMP)
cholesterol metabolic process  (ISO)
coronary vasculature development  (ISO)
enzyme linked receptor protein signaling pathway  (ISO)
lipoprotein metabolic process  (IEP)
lysosomal transport  (ISO)
negative regulation of apoptotic process  (IMP)
negative regulation of cell death  (IMP)
negative regulation of cell-substrate adhesion  (IMP)
negative regulation of cytosolic calcium ion concentration  (IMP)
negative regulation of endopeptidase activity  (IC)
negative regulation of focal adhesion assembly  (IMP)
negative regulation of gene expression  (ISO)
negative regulation of neuron apoptotic process  (IDA,IMP)
negative regulation of neuron projection development  (IMP)
negative regulation of pathway-restricted SMAD protein phosphorylation  (ISO)
negative regulation of platelet-derived growth factor receptor-beta signaling pathway  (ISO)
negative regulation of SMAD protein signal transduction  (ISO)
negative regulation of smooth muscle cell migration  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
negative regulation of Wnt signaling pathway  (ISO)
phagocytosis  (ISO)
positive regulation of amyloid-beta clearance  (ISO)
positive regulation of axon extension  (IMP)
positive regulation of axon extension involved in regeneration  (IDA)
positive regulation of cell death  (ISO)
positive regulation of chemokine (C-X-C motif) ligand 2 production  (IMP)
positive regulation of cholesterol efflux  (ISO)
positive regulation of cholesterol import  (IMP)
positive regulation of collateral sprouting of injured axon  (IDA)
positive regulation of cytosolic calcium ion concentration  (IMP)
positive regulation of endocytosis  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IMP)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (IMP)
positive regulation of lipid transport  (ISO)
positive regulation of lysosomal protein catabolic process  (ISO)
positive regulation of neuron projection development  (IMP)
positive regulation of phagocytosis  (IMP)
positive regulation of protein binding  (ISO)
positive regulation of protein localization to plasma membrane  (ISO)
positive regulation of protein transport  (IMP)
positive regulation of Schwann cell migration  (IMP)
positive regulation of transcytosis  (ISO)
positive regulation of vascular associated smooth muscle cell migration  (IMP)
protein kinase C-activating G protein-coupled receptor signaling pathway  (IMP)
receptor-mediated endocytosis  (IMP,ISO)
regulation of actin cytoskeleton organization  (ISO)
regulation of cholesterol transport  (ISO)
regulation of phospholipase A2 activity  (ISO)
regulation of pulmonary blood vessel remodeling  (ISO)
transport across blood-brain barrier  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Barmina OY, etal., J Biol Chem. 1999 Oct 15;274(42):30087-93.
2. Behl M, etal., Neurotoxicology. 2010 Sep;31(5):524-32. doi: 10.1016/j.neuro.2010.05.004. Epub 2010 May 19.
3. Brown MD, etal., Brain Res. 1997 Feb 7;747(2):313-7.
4. Cal R, etal., Cardiovasc Res. 2012 Jun 1;94(3):469-79. doi: 10.1093/cvr/cvs136. Epub 2012 Mar 27.
5. Campana WM, etal., J Neurosci. 2006 Oct 25;26(43):11197-207. doi: 10.1523/JNEUROSCI.2709-06.2006.
6. Espirito Santo SM, etal., Blood. 2004 May 15;103(10):3777-82. Epub 2004 Jan 22.
7. Field PA and Gibbons GF, Metabolism. 2000 Apr;49(4):492-8.
8. Fred RG, etal., Clin Sci (Lond). 2015 Jan;128(1):17-28. doi: 10.1042/CS20130560.
9. Gaultier A, etal., J Cell Sci. 2009 Apr 15;122(Pt 8):1155-62. doi: 10.1242/jcs.040717. Epub 2009 Mar 19.
10. Gaultier A, etal., J Clin Invest. 2008 Jan;118(1):161-72. doi: 10.1172/JCI32371.
11. Gilardoni MB, etal., J Histochem Cytochem. 2003 Dec;51(12):1575-80.
12. GOA data from the GO Consortium
13. Grey A, etal., Mol Endocrinol. 2004 Sep;18(9):2268-78. Epub 2004 Jun 3.
14. Harasaki K, etal., Traffic. 2005 Nov;6(11):1014-26.
15. Hayashi H, etal., J Biol Chem. 2012 Jul 20;287(30):25395-406. doi: 10.1074/jbc.M112.370130. Epub 2012 Jun 6.
16. Hayashi H, etal., J Neurosci. 2007 Feb 21;27(8):1933-41.
17. Hu K, etal., J Biol Chem. 2006 Jan 27;281(4):2120-7. Epub 2005 Nov 22.
18. Hu K, etal., J Clin Invest. 2007 Dec;117(12):3821-32.
19. Hu Q, etal., Mol Med Rep. 2018 Jan;17(1):827-834. doi: 10.3892/mmr.2017.7983. Epub 2017 Nov 6.
20. Ikoma-Seki K, etal., PLoS One. 2015 Oct 27;10(10):e0141378. doi: 10.1371/journal.pone.0141378. eCollection 2015.
21. Ishii M, etal., Brain Res. 1996 Oct 21;737(1-2):269-74.
22. Jedrychowski MP, etal., J Biol Chem. 2010 Jan 1;285(1):104-14. doi: 10.1074/jbc.M109.040428. Epub 2009 Oct 28.
23. Jung HO, etal., Biochem Biophys Res Commun. 2010 Nov 26;402(4):577-82. doi: 10.1016/j.bbrc.2010.10.019. Epub 2010 Oct 19.
24. Kang LI, etal., Lab Invest. 2015 Oct;95(10):1117-29. doi: 10.1038/labinvest.2015.94. Epub 2015 Aug 3.
25. Lambert JC, etal., Lancet 1998 Jun 13;351(9118):1787-8.
26. Landowski LM, etal., J Biol Chem. 2016 Jan 15;291(3):1092-102. doi: 10.1074/jbc.M115.668996. Epub 2015 Nov 23.
27. Liu Y, etal., Nat Med. 2000 Dec;6(12):1380-7.
28. Luo Y, etal., Mech Ageing Dev. 2009 Apr;130(4):248-52. doi: 10.1016/j.mad.2008.12.005. Epub 2008 Dec 27.
29. Mantuano E, etal., J Biol Chem. 2010 May 7;285(19):14259-66. doi: 10.1074/jbc.M109.085126. Epub 2010 Mar 2.
30. Martin AM, etal., J Biol Chem. 2008 May 2;283(18):12004-13. doi: 10.1074/jbc.M707607200. Epub 2008 Mar 5.
31. Matsuo M, etal., Biochim Biophys Acta. 2011 Jan;1811(1):31-8. Epub 2010 Oct 30.
32. May P, etal., Mol Cell Biol 2004 Oct;24(20):8872-83.
33. McCarthy JJ, etal., J Med Genet. 2004 May;41(5):334-41.
34. MGD data from the GO Consortium
35. Moon JH, etal., J Mol Endocrinol. 2012 Oct 10;49(3):165-74. doi: 10.1530/JME-12-0119. Print 2012 Dec.
36. Overton CD, etal., Circ Res. 2007 Mar 16;100(5):670-7. Epub 2007 Feb 15.
37. Parkyn CJ, etal., J Cell Sci. 2008 Mar 15;121(Pt 6):773-83. doi: 10.1242/jcs.021816. Epub 2008 Feb 19.
38. Pipeline to import KEGG annotations from KEGG into RGD
39. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
40. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
41. RGD automated import pipeline for gene-chemical interactions
42. Sanchez MC, etal., Exp Eye Res. 2006 Dec;83(6):1378-85. Epub 2006 Sep 15.
43. Schulz S, etal., Hum Mutat. 2002 Nov;20(5):404.
44. Shi Y, etal., J Neurosci Res. 2011 Apr;89(4):544-51. doi: 10.1002/jnr.22576. Epub 2011 Feb 2.
45. Stefansson S, etal., J Biol Chem. 1996 Apr 5;271(14):8215-20.
46. Stiles TL, etal., J Cell Sci. 2013 Jan 1;126(Pt 1):209-20. doi: 10.1242/jcs.113191. Epub 2012 Nov 6.
47. Tanahashi H and Tabira T, Biochem J. 2002 Nov 1;367(Pt 3):687-95. doi: 10.1042/BJ20020562.
48. Verges M, etal., J Biol Chem. 2004 Mar 5;279(10):9030-6. Epub 2003 Dec 29.
49. Wei B, etal., Brain Res. 2016 Jan 15;1631:157-64. doi: 10.1016/j.brainres.2015.11.041. Epub 2015 Dec 2.
50. Yamauchi K, etal., PLoS One. 2013 Sep 23;8(9):e75497. doi: 10.1371/journal.pone.0075497. eCollection 2013.
51. Yoon C, etal., J Biol Chem. 2013 Sep 13;288(37):26557-68. doi: 10.1074/jbc.M113.478552. Epub 2013 Jul 18.
Additional References at PubMed
PMID:2779654   PMID:3266596   PMID:12477932   PMID:15082773   PMID:15647754   PMID:16207730   PMID:16445910   PMID:16489109   PMID:16929031   PMID:17012232   PMID:17897319   PMID:17920016  
PMID:17963731   PMID:18281370   PMID:18635818   PMID:18940800   PMID:19047013   PMID:19098903   PMID:19299737   PMID:19501112   PMID:19718435   PMID:19742316   PMID:20630619   PMID:21289173  
PMID:21423176   PMID:21585370   PMID:21703209   PMID:21795536   PMID:21940431   PMID:22658674   PMID:23152628   PMID:23192564   PMID:23382219   PMID:23386614   PMID:23812296   PMID:24129569  
PMID:24305823   PMID:25218173   PMID:25807483   PMID:26005850   PMID:26142438   PMID:26370502   PMID:26619118   PMID:26781079   PMID:30649678   PMID:30703614   PMID:31350035   PMID:32788217  


Genomics

Comparative Map Data
Lrp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2763,380,325 - 63,461,029 (-)NCBI
Rnor_6.0 Ensembl770,846,344 - 70,926,903 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0770,846,313 - 70,927,028 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0771,018,808 - 71,099,367 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4767,520,575 - 67,601,549 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1767,541,343 - 67,622,669 (-)NCBI
Celera760,519,175 - 60,599,687 (-)NCBICelera
Cytogenetic Map7q22NCBI
LRP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1257,128,483 - 57,213,361 (+)EnsemblGRCh38hg38GRCh38
GRCh381257,128,401 - 57,213,377 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371257,522,266 - 57,607,144 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361255,808,549 - 55,893,409 (+)NCBINCBI36hg18NCBI36
Build 341255,808,548 - 55,893,390NCBI
Celera1257,176,220 - 57,261,424 (+)NCBI
Cytogenetic Map12q13.3NCBI
HuRef1254,560,642 - 54,624,427 (+)NCBIHuRef
HuRef1254,625,579 - 54,646,229 (+)NCBIHuRef
CHM1_11257,489,966 - 57,575,252 (+)NCBICHM1_1
Lrp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910127,374,026 - 127,457,158 (-)NCBIGRCm39mm39
GRCm39 Ensembl10127,374,030 - 127,457,017 (-)Ensembl
GRCm3810127,538,157 - 127,621,148 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,538,161 - 127,621,148 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710126,975,213 - 127,058,204 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610126,941,137 - 127,024,078 (-)NCBImm8
Celera10129,930,007 - 130,012,542 (-)NCBICelera
Cytogenetic Map10D3NCBI
Lrp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554584,861,431 - 4,941,146 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554584,861,431 - 4,941,939 (+)NCBIChiLan1.0ChiLan1.0
LRP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11231,966,149 - 32,051,979 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1231,966,149 - 32,051,979 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01231,713,938 - 31,799,287 (-)NCBIMhudiblu_PPA_v0panPan3
LRP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1101,260,256 - 1,341,705 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl101,260,719 - 1,352,271 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha101,324,330 - 1,405,506 (+)NCBI
ROS_Cfam_1.0101,270,934 - 1,352,176 (+)NCBI
UMICH_Zoey_3.1101,247,639 - 1,328,819 (+)NCBI
UNSW_CanFamBas_1.0101,489,631 - 1,570,787 (+)NCBI
UU_Cfam_GSD_1.0101,614,746 - 1,695,694 (+)NCBI
Lrp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494557,463,638 - 57,543,337 (-)NCBI
SpeTri2.0NW_0049366461,326,900 - 1,407,236 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1522,435,636 - 22,519,276 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2524,186,409 - 24,202,094 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11153,039,147 - 53,125,041 (+)NCBI
ChlSab1.1 Ensembl1153,039,364 - 53,125,776 (+)Ensembl
Vero_WHO_p1.0NW_023666037192,847,266 - 192,933,317 (-)NCBI
Lrp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462480210,734,907 - 10,812,888 (-)NCBI

Position Markers
RH132158  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2763,380,516 - 63,380,721 (+)MAPPER
Rnor_6.0770,846,505 - 70,846,709NCBIRnor6.0
Rnor_5.0771,018,969 - 71,019,173UniSTSRnor5.0
RGSC_v3.4767,520,775 - 67,520,979UniSTSRGSC3.4
Celera760,519,336 - 60,519,540UniSTS
Cytogenetic Map7q22UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)72920071124838025Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)712328467106995532Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72536563393155402Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72820465373204653Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)73138152976381529Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)73203505377035053Rat
61439Cia8Collagen induced arthritis QTL 85.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)73257294277572942Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)73304444971352127Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)73586772980867729Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)73586772993155402Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73854770683547706Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)74087268285872682Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)74087268285872682Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74530157390301573Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)748118835128611831Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)75025210395252103Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)750704769128085642Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)75079381895793818Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)751251919118477612Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)751251919145729302Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)751252005111589099Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)75320034498200344Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)75425951299259512Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)75453499673293934Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)755072862123602998Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)755072862123602998Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)755072862123602998Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)755495689100495689Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)755495689100495689Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)755495689100495689Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)755495689100495689Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)755495689100495689Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)755495689100495689Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)755495689100495689Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)761047589113228378Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)768518460113518460Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)769399586111043530Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)769399586111043530Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)770421228115421228Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:212
Count of miRNA genes:155
Interacting mature miRNAs:171
Transcripts:ENSRNOT00000031005
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 41 56 41 18 41 8 10 74 29 40 11 8
Low 1 2 1 1 1 6 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000031005   ⟹   ENSRNOP00000034210
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl770,846,344 - 70,926,903 (-)Ensembl
RefSeq Acc Id: NM_001130490   ⟹   NP_001123962
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2763,380,356 - 63,460,910 (-)NCBI
Rnor_6.0770,846,344 - 70,926,903 (-)NCBI
Rnor_5.0771,018,808 - 71,099,367 (-)NCBI
Celera760,519,175 - 60,599,687 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008765393   ⟹   XP_008763615
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2763,380,325 - 63,461,029 (-)NCBI
Rnor_6.0770,846,313 - 70,927,028 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001123962 (Get FASTA)   NCBI Sequence Viewer  
  XP_008763615 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH88327 (Get FASTA)   NCBI Sequence Viewer  
  EDM16460 (Get FASTA)   NCBI Sequence Viewer  
  G3V928 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001123962   ⟸   NM_001130490
- Peptide Label: precursor
- UniProtKB: G3V928 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008763615   ⟸   XM_008765393
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000034210   ⟸   ENSRNOT00000031005
Protein Domains
EGF-like   LDL-receptor class A

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695265
Promoter ID:EPDNEW_R5789
Type:initiation region
Name:Lrp1_1
Description:LDL receptor related protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0770,926,843 - 70,926,903EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307535 AgrOrtholog
Ensembl Genes ENSRNOG00000025053 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000034210 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000031005 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.120.10.30 UniProtKB/Swiss-Prot
  4.10.400.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7365242 IMAGE-MGC_LOAD
InterPro 6-blade_b-propeller_TolB-like UniProtKB/Swiss-Prot
  cEGF UniProtKB/Swiss-Prot
  DUF5050 UniProtKB/Swiss-Prot
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot
  EGF-like_dom UniProtKB/Swiss-Prot
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  LDL_receptor-like_sf UniProtKB/Swiss-Prot
  LDLR_class-A_CS UniProtKB/Swiss-Prot
  LDLR_classB_rpt UniProtKB/Swiss-Prot
  LDrepeatLR_classA_rpt UniProtKB/Swiss-Prot
KEGG Report rno:299858 UniProtKB/Swiss-Prot
MGC_CLONE MGC:109576 IMAGE-MGC_LOAD
NCBI Gene 299858 ENTREZGENE
Pfam cEGF UniProtKB/Swiss-Prot
  DUF5050 UniProtKB/Swiss-Prot
  EGF UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  Ldl_recept_a UniProtKB/Swiss-Prot
  Ldl_recept_b UniProtKB/Swiss-Prot
PhenoGen Lrp1 PhenoGen
PRINTS LDLRECEPTOR UniProtKB/Swiss-Prot
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot
  EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  LDLRA_1 UniProtKB/Swiss-Prot
  LDLRA_2 UniProtKB/Swiss-Prot
  LDLRB UniProtKB/Swiss-Prot
SMART EGF UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  LDLa UniProtKB/Swiss-Prot
  SM00135 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57184 UniProtKB/Swiss-Prot
  SSF57424 UniProtKB/Swiss-Prot
UniProt G3V928 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q5I0H1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-21 Lrp1  LDL receptor related protein 1  Lrp1  low density lipoprotein receptor-related protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Lrp1  low density lipoprotein receptor-related protein 1  Lrp1  low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Lrp1  low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)  Lrp1  low density lipoprotein receptor-related protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Lrp1  low density lipoprotein receptor-related protein 1  Lrp1_predicted  low density lipoprotein receptor-related protein 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Lrp1_predicted  low density lipoprotein receptor-related protein 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED