RGD Reference Report - Hippocampal NMDAR-Wnt-Catenin signaling disrupted with cognitive deficits in adolescent offspring exposed to prenatal hypoxia. - Rat Genome Database

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Hippocampal NMDAR-Wnt-Catenin signaling disrupted with cognitive deficits in adolescent offspring exposed to prenatal hypoxia.

Authors: Wei, Bin  Li, Lingjun  He, Axin  Zhang, Yingying  Sun, Miao  Xu, Zhice 
Citation: Wei B, etal., Brain Res. 2016 Jan 15;1631:157-64. doi: 10.1016/j.brainres.2015.11.041. Epub 2015 Dec 2.
RGD ID: 13792690
Pubmed: (View Article at PubMed) PMID:26656067
DOI: Full-text: DOI:10.1016/j.brainres.2015.11.041

Prenatal hypoxia (PH) is one of the most common stresses on fetuses, and might lead to abnormal brain development. This work investigates whether PH affects behavioral development of the learning/memory ability in the adolescent offspring rats and the underlying molecular basis in the brain. In this study, pregnant rats used to generate PH offspring were treated with hypoxia (10.5% oxygen) from gestational day 4 to 21. Brain weights of either the fetuses or the 6-week old offspring in the PH group were found to be significantly lower compared with the control group. Morris water maze tests showed longer escape latency and swimming distance during navigation testing in the PH offspring; retention tests demonstrated less frequency of crossing target areas indicating impaired learning and memory ability in the PH offspring. The expressions of subunits of N-methyl-D-aspartate receptors (NMDARs), Grin1/NR1, Grin2a/NR2A, and Grin2b/NR2B, were significantly decreased in the hippocampus of adolescent offspring in the PH group. Wnt3a as well as active form of ß-catenin protein were also significantly down-regulated. Furthermore, the expression of early response gene, Fosl1, was significantly reduced. The results above provide new evidence that PH might result in the spatial acquisition and retrieval deficits in the adolescent offspring, associated with dysregulation of NMDARs-Wnt-Catenin signaling in the hippocampus. This study result deepens the knowledge of the long-term influence of prenatal insults on the neuro-behavioral development.

Annotation

Disease Annotations    

Gene Ontology Annotations    

Biological Process

Objects Annotated

Genes (Rattus norvegicus)
Grin1  (glutamate ionotropic receptor NMDA type subunit 1)
Grin2a  (glutamate ionotropic receptor NMDA type subunit 2A)
Grin2b  (glutamate ionotropic receptor NMDA type subunit 2B)
Lrp1  (LDL receptor related protein 1)

Genes (Mus musculus)
Grin1  (glutamate receptor, ionotropic, NMDA1 (zeta 1))
Grin2a  (glutamate receptor, ionotropic, NMDA2A (epsilon 1))
Grin2b  (glutamate receptor, ionotropic, NMDA2B (epsilon 2))
Lrp1  (low density lipoprotein receptor-related protein 1)

Genes (Homo sapiens)
GRIN1  (glutamate ionotropic receptor NMDA type subunit 1)
GRIN2A  (glutamate ionotropic receptor NMDA type subunit 2A)
GRIN2B  (glutamate ionotropic receptor NMDA type subunit 2B)
LRP1  (LDL receptor related protein 1)


Additional Information