PLAT (plasminogen activator, tissue type) - Rat Genome Database
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Gene: PLAT (plasminogen activator, tissue type) Homo sapiens
Analyze
Symbol: PLAT
Name: plasminogen activator, tissue type
RGD ID: 736468
HGNC Page HGNC
Description: Exhibits phosphoprotein binding activity; serine-type endopeptidase activity; and signaling receptor binding activity. Involved in negative regulation of proteolysis and plasminogen activation. Localizes to cell surface and cytoplasm. Implicated in several diseases, including antiphospholipid syndrome; diabetic angiopathy; factor VIII deficiency; osteonecrosis; and thrombophilia due to decreased release of PLAT. Biomarker of several diseases, including Henoch-Schoenlein purpura; acute promyelocytic leukemia; autoimmune thrombocytopenic purpura; blood coagulation disease (multiple); and diabetes mellitus (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: alteplase; DKFZp686I03148; plasminogen/activator kringle; reteplase; T-PA; t-plasminogen activator; tissue plasminogen activator (t-PA); tissue-type plasminogen activator; TPA
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl842,174,718 - 42,207,709 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl842,174,718 - 42,207,676 (-)EnsemblGRCh38hg38GRCh38
GRCh38842,174,718 - 42,207,565 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37842,032,236 - 42,065,083 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36842,151,393 - 42,184,351 (-)NCBINCBI36hg18NCBI36
Build 34842,151,911 - 42,184,351NCBI
Celera840,981,190 - 41,014,147 (-)NCBI
Cytogenetic Map8p11.21NCBI
HuRef840,559,713 - 40,592,984 (-)NCBIHuRef
CHM1_1842,080,535 - 42,113,859 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IEP)
acute promyelocytic leukemia  (IEP)
Acute Traumatic Coagulopathy  (ISO)
Airway Obstruction  (EXP)
allergic contact dermatitis  (EXP)
amphetamine abuse  (EXP)
angioedema  (EXP)
antiphospholipid syndrome  (IDA)
aphasia  (EXP)
Arterial Occlusive Diseases  (EXP)
Arterial Thrombosis  (IDA)
atherosclerosis  (EXP)
autoimmune thrombocytopenic purpura  (IEP)
Back Pain  (EXP)
Bacteremia  (EXP)
blood coagulation disease  (IEP)
brain edema  (EXP,ISO)
brain infarction  (EXP)
brain ischemia  (EXP,IAGP)
Burns  (IEP)
cardiac tamponade  (EXP)
Cardiogenic Shock  (EXP)
Carotid Artery Injuries  (ISO)
Central Nervous System Viral Diseases  (ISO)
Cerebral Hemorrhage  (EXP,ISO)
cerebral infarction  (EXP)
Chemical and Drug Induced Liver Injury  (EXP)
cholesterol embolism  (EXP)
Chronic Hepatitis  (IEP)
congestive heart failure  (EXP)
coronary thrombosis  (EXP)
diabetic angiopathy  (IDA)
Diabetic Foot  (IDA)
Diabetic Nephropathies  (IEP)
diabetic neuropathy  (IEP)
disseminated intravascular coagulation  (IEP,ISO)
Embolism  (EXP)
Embolism and Thrombosis  (EXP)
Endotoxemia  (IDA)
Experimental Liver Cirrhosis  (EXP,ISO)
factor VIII deficiency  (IDA)
Femur Head Necrosis  (IAGP)
gestational diabetes  (IEP)
Hematoma, Epidural, Spinal  (EXP)
hemolytic-uremic syndrome  (IEP)
Hemorrhage  (EXP)
hemorrhagic disease  (IAGP)
Henoch-Schoenlein purpura  (IEP)
hypertension  (EXP)
Hypotension  (EXP)
Hypoxia  (EXP)
Hypoxia-Ischemia, Brain  (ISO)
Intracranial Embolism and Thrombosis  (EXP)
Intracranial Hemorrhages  (EXP)
intracranial thrombosis  (EXP)
intracranial vasospasm  (EXP)
lactic acidosis  (EXP)
leukopenia  (IEP)
Low Back Pain  (EXP)
meningoencephalitis  (EXP)
Metabolic Syndrome  (IEP)
middle cerebral artery infarction  (EXP,ISO)
Multiple Organ Failure  (ISO)
myocardial infarction  (EXP,IAGP,IDA)
Nerve Degeneration  (EXP)
Neurologic Manifestations  (EXP)
Noonan syndrome  (IEP)
obesity  (IEP)
pancreatic adenocarcinoma  (IEP)
Paresis  (EXP)
pericardial effusion  (EXP)
peritonitis  (IDA)
pulmonary embolism  (EXP)
Reperfusion Injury  (EXP,ISO)
respiratory failure  (EXP)
Right Ventricular Hypertrophy  (ISO)
sciatic neuropathy  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (IEP)
Spinal Cord Compression  (EXP)
status epilepticus  (ISO)
Stroke  (EXP,IDA,IEP)
Subdural Hematoma  (EXP)
thrombocytopenia  (IAGP)
Thromboembolism  (EXP)
thrombophilia due to decreased release of PLAT  (IAGP)
thrombosis  (EXP)
toxic encephalopathy  (EXP)
transient cerebral ischemia  (ISO)
Transplant Rejection  (IEP)
type 1 diabetes mellitus  (IEP)
type 2 diabetes mellitus  (IDA,IEP,ISO)
Venous Thromboembolism  (EXP)
Venous Thrombosis  (EXP,IAGP)
Ventricular Dysfunction, Left  (EXP)
von Willebrand's disease 1  (IDA)
Wounds and Injuries  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP,ISO)
(-)-epigallocatechin 3-gallate  (EXP)
(R)-mevalonic acid  (EXP,ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (EXP)
9-cis-retinoic acid  (EXP)
acetamide  (ISO)
actinomycin D  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
aldosterone  (ISO)
all-trans-4-oxoretinoic acid  (EXP)
all-trans-retinoic acid  (EXP,ISO)
aminoguanidine  (EXP)
ammonium chloride  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
beta-carotene  (ISO)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bucladesine  (EXP)
butan-1-ol  (EXP)
butanal  (EXP)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (ISO)
calciol  (ISO)
carbamazepine  (EXP)
carbon nanotube  (EXP,ISO)
chloroprene  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
cisplatin  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
cytarabine  (EXP)
cytochalasin D  (EXP)
D-glucose  (ISO)
daunorubicin  (EXP)
DDT  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
dibenzo[a,l]pyrene  (EXP)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
dienogest  (EXP)
diethyl maleate  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (EXP,ISO)
dipyridamole  (EXP)
diuron  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP)
edaravone  (ISO)
endosulfan  (ISO)
ethanol  (EXP,ISO)
Ethyl icosapentate  (ISO)
ethylenediaminetetraacetic acid  (ISO)
eugenol  (EXP)
fenbuconazole  (EXP)
folic acid  (ISO)
fructose  (EXP)
furan  (ISO)
genistein  (EXP,ISO)
geranylgeraniol  (EXP)
gestodene  (EXP)
glucose  (ISO)
Goe 6976  (ISO)
GW 4064  (ISO)
heparin  (ISO)
icatibant  (EXP)
indometacin  (EXP)
irinotecan  (EXP,ISO)
isobutanol  (EXP)
isoprenaline  (ISO)
isotretinoin  (EXP)
ketamine  (ISO)
KT 5823  (EXP)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
levonorgestrel  (EXP)
lipopolysaccharide  (ISO)
losartan  (ISO)
lovastatin  (ISO)
malathion  (EXP)
medroxyprogesterone acetate  (EXP)
metformin  (EXP)
methamphetamine  (ISO)
methotrexate  (EXP)
mifepristone  (EXP,ISO)
mitoxantrone  (EXP)
morphine  (ISO)
N-acetylsphingosine  (EXP)
N-nitrosodimethylamine  (ISO)
naphthalene  (ISO)
nickel sulfate  (EXP,ISO)
nicotine  (EXP)
nitric oxide  (ISO)
nonanedioic acid  (EXP)
norgestimate  (EXP)
notoginsenoside R1  (EXP)
oxaliplatin  (ISO)
ozone  (ISO)
panobinostat  (EXP)
paracetamol  (ISO)
pentanal  (EXP)
pentane-2,3-dione  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
pirinixic acid  (ISO)
piroxicam  (EXP)
potassium chromate  (EXP)
prednisone  (EXP)
procymidone  (ISO)
progesterone  (EXP,ISO)
propanal  (EXP)
protoporphyrin  (EXP)
quercetin  (EXP,ISO)
raloxifene  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (EXP)
Ro 41-5253  (EXP)
rofecoxib  (EXP)
SB 431542  (EXP)
SCH 23390  (ISO)
silicon dioxide  (EXP)
simvastatin  (EXP,ISO)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
sotalol  (ISO)
spironolactone  (EXP)
sulforaphane  (EXP)
sulindac  (EXP)
tacrolimus hydrate  (ISO)
tetrachloromethane  (ISO)
tetraethyllead  (ISO)
tetraphene  (ISO)
titanium dioxide  (ISO)
toluene  (ISO)
topotecan  (ISO)
Trapidil  (ISO)
trichostatin A  (EXP)
triclosan  (EXP)
urethane  (EXP)
valproic acid  (EXP,ISO)
vincaleukoblastine  (ISO)
vinclozolin  (ISO)
vincristine  (ISO)
vitamin E  (ISO)
vorinostat  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
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Additional References at PubMed
PMID:1301152   PMID:1310033   PMID:1368681   PMID:1502153   PMID:1602484   PMID:1632457   PMID:1645336   PMID:1695900   PMID:1762144   PMID:1783394   PMID:1900431   PMID:1901789  
PMID:1909331   PMID:1930175   PMID:2107490   PMID:2107528   PMID:2110366   PMID:2496749   PMID:2503541   PMID:2513186   PMID:2551064   PMID:2558718   PMID:2745554   PMID:2838384  
PMID:2962641   PMID:3009482   PMID:3087818   PMID:3088041   PMID:3090045   PMID:3090401   PMID:3103680   PMID:3126346   PMID:3133640   PMID:3161893   PMID:3839198   PMID:3896853  
PMID:6089198   PMID:6337343   PMID:6433976   PMID:6538514   PMID:6538515   PMID:6572897   PMID:6682760   PMID:7582899   PMID:7586269   PMID:7721771   PMID:7876253   PMID:8186264  
PMID:8360181   PMID:8366113   PMID:8508955   PMID:8533091   PMID:8607113   PMID:8613982   PMID:9268299   PMID:9305622   PMID:9359841   PMID:9434908   PMID:9988531   PMID:10340997  
PMID:10543954   PMID:10632583   PMID:10956663   PMID:11170397   PMID:11371191   PMID:11384978   PMID:11385207   PMID:11450845   PMID:11507973   PMID:11734662   PMID:11734664   PMID:11816707  
PMID:11858184   PMID:11864703   PMID:11864708   PMID:11928812   PMID:11928826   PMID:11963567   PMID:11978811   PMID:11986218   PMID:11988309   PMID:12023848   PMID:12090757   PMID:12123488  
PMID:12167592   PMID:12228252   PMID:12354288   PMID:12390834   PMID:12445472   PMID:12468550   PMID:12468767   PMID:12477932   PMID:12484521   PMID:12524082   PMID:12544724   PMID:12544772  
PMID:12589088   PMID:12643326   PMID:12694198   PMID:12719777   PMID:12719778   PMID:12726991   PMID:12727218   PMID:12794725   PMID:12891381   PMID:12913003   PMID:12941043   PMID:14500731  
PMID:14529669   PMID:14592829   PMID:14608053   PMID:14697941   PMID:14746139   PMID:14759258   PMID:14983221   PMID:15016824   PMID:15031453   PMID:15080889   PMID:15109703   PMID:15116264  
PMID:15119966   PMID:15140132   PMID:15207811   PMID:15269833   PMID:15448144   PMID:15466927   PMID:15489334   PMID:15541709   PMID:15542697   PMID:15550028   PMID:15629242   PMID:15652516  
PMID:15721275   PMID:15861134   PMID:15869598   PMID:15916851   PMID:16015279   PMID:16037259   PMID:16113755   PMID:16248996   PMID:16344560   PMID:16356191   PMID:16369808   PMID:16385091  
PMID:16410064   PMID:16466010   PMID:16614319   PMID:16706993   PMID:16828203   PMID:16836660   PMID:16839347   PMID:16879221   PMID:16953275   PMID:17003923   PMID:17064755   PMID:17145060  
PMID:17151781   PMID:17207964   PMID:17257155   PMID:17264956   PMID:17287634   PMID:17320454   PMID:17408411   PMID:17419735   PMID:17458906   PMID:17473573   PMID:17608581   PMID:17649957  
PMID:17661167   PMID:17681507   PMID:17689414   PMID:17849409   PMID:17934860   PMID:17986506   PMID:18023202   PMID:18029284   PMID:18029348   PMID:18037995   PMID:18057060   PMID:18194423  
PMID:18202522   PMID:18289715   PMID:18321860   PMID:18331597   PMID:18419748   PMID:18449420   PMID:18468424   PMID:18472001   PMID:18541262   PMID:18574075   PMID:18629628   PMID:18647223  
PMID:18662099   PMID:18690354   PMID:18714030   PMID:18720901   PMID:18818748   PMID:18922856   PMID:18925455   PMID:18953568   PMID:18974842   PMID:18977990   PMID:18983502   PMID:19019335  
PMID:19061349   PMID:19085655   PMID:19088796   PMID:19116134   PMID:19171142   PMID:19176991   PMID:19217651   PMID:19222708   PMID:19238444   PMID:19257978   PMID:19290852   PMID:19356953  
PMID:19483400   PMID:19492158   PMID:19513384   PMID:19526059   PMID:19527514   PMID:19538480   PMID:19578796   PMID:19698976   PMID:19718485   PMID:19730683   PMID:19874473   PMID:19913121  
PMID:19929406   PMID:19948975   PMID:20097831   PMID:20140262   PMID:20217999   PMID:20218002   PMID:20409678   PMID:20445443   PMID:20447686   PMID:20452482   PMID:20458337   PMID:20472470  
PMID:20500107   PMID:20508517   PMID:20559098   PMID:20628086   PMID:20628624   PMID:20673868   PMID:20811636   PMID:20838737   PMID:20845058   PMID:21034162   PMID:21082259   PMID:21158116  
PMID:21174002   PMID:21282301   PMID:21304999   PMID:21314733   PMID:21392255   PMID:21414238   PMID:21437359   PMID:21501649   PMID:21576385   PMID:21791417   PMID:21848677   PMID:21868730  
PMID:21873635   PMID:21898905   PMID:21900343   PMID:22027013   PMID:22035541   PMID:22037173   PMID:22104068   PMID:22178875   PMID:22187433   PMID:22199357   PMID:22240314   PMID:22577291  
PMID:22610100   PMID:22771216   PMID:22778398   PMID:22787391   PMID:22957978   PMID:22974122   PMID:23082219   PMID:23117722   PMID:23118500   PMID:23161549   PMID:23306318   PMID:23317922  
PMID:23326456   PMID:23376485   PMID:23423137   PMID:23570848   PMID:23788583   PMID:23939410   PMID:23959729   PMID:24108470   PMID:24114008   PMID:24126163   PMID:24129569   PMID:24145699  
PMID:24196407   PMID:24578379   PMID:24709679   PMID:24712925   PMID:24718307   PMID:24764453   PMID:24815086   PMID:24825926   PMID:24918201   PMID:24964508   PMID:25059665   PMID:25113642  
PMID:25306554   PMID:25329379   PMID:25339163   PMID:25474480   PMID:25627976   PMID:25670787   PMID:25855589   PMID:25970741   PMID:26002716   PMID:26186194   PMID:26324706   PMID:26339655  
PMID:26469972   PMID:26528141   PMID:26548921   PMID:26626577   PMID:26704613   PMID:26881424   PMID:26942412   PMID:27212010   PMID:27417437   PMID:27690691   PMID:27831563   PMID:27975104  
PMID:28193577   PMID:28254694   PMID:28514442   PMID:28648598   PMID:28684538   PMID:28692057   PMID:28710283   PMID:28754830   PMID:28882880   PMID:29028593   PMID:29118335   PMID:29930084  
PMID:29962211   PMID:30442055   PMID:30597502   PMID:30602990   PMID:30669988   PMID:30690783   PMID:30747704   PMID:31073040   PMID:31104419   PMID:31106414   PMID:32353859   PMID:32657780  
PMID:32977685   PMID:33060197  


Genomics

Comparative Map Data
PLAT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl842,174,718 - 42,207,709 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl842,174,718 - 42,207,676 (-)EnsemblGRCh38hg38GRCh38
GRCh38842,174,718 - 42,207,565 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37842,032,236 - 42,065,083 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36842,151,393 - 42,184,351 (-)NCBINCBI36hg18NCBI36
Build 34842,151,911 - 42,184,351NCBI
Celera840,981,190 - 41,014,147 (-)NCBI
Cytogenetic Map8p11.21NCBI
HuRef840,559,713 - 40,592,984 (-)NCBIHuRef
CHM1_1842,080,535 - 42,113,859 (-)NCBICHM1_1
Plat
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39823,247,655 - 23,272,864 (+)NCBIGRCm39mm39
GRCm39 Ensembl823,247,743 - 23,272,860 (+)Ensembl
GRCm38822,757,722 - 22,782,848 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl822,757,727 - 22,782,844 (+)EnsemblGRCm38mm10GRCm38
MGSCv37823,868,216 - 23,893,320 (+)NCBIGRCm37mm9NCBIm37
MGSCv36824,223,313 - 24,248,389 (+)NCBImm8
Celera824,247,228 - 24,272,480 (+)NCBICelera
Cytogenetic Map8A2NCBI
cM Map811.42NCBI
Plat
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21669,240,582 - 69,265,177 (-)NCBI
Rnor_6.0 Ensembl1674,098,260 - 74,122,889 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01674,098,263 - 74,122,897 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01673,730,256 - 73,754,851 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41673,711,323 - 73,736,328 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11673,711,587 - 73,736,593 (-)NCBI
Celera1667,134,451 - 67,159,047 (-)NCBICelera
RH 3.4 Map16644.8RGD
Cytogenetic Map16q12.5NCBI
Plat
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955536730,981 - 756,394 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955536730,962 - 754,333 (+)NCBIChiLan1.0ChiLan1.0
PLAT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1838,864,918 - 38,897,776 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl838,864,918 - 38,897,779 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0841,419,415 - 41,451,951 (-)NCBIMhudiblu_PPA_v0panPan3
PLAT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11623,469,590 - 23,496,013 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1623,974,129 - 24,000,506 (+)NCBI
ROS_Cfam_1.01625,217,768 - 25,244,182 (+)NCBI
UMICH_Zoey_3.11623,588,653 - 23,615,286 (+)NCBI
UNSW_CanFamBas_1.01624,152,407 - 24,178,867 (+)NCBI
UU_Cfam_GSD_1.01624,203,090 - 24,229,785 (+)NCBI
Plat
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_ltri_2NW_02440494346,519,711 - 46,546,290 (+)NCBI
SpeTri2.0NW_004936785476,200 - 503,371 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLAT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1711,195,602 - 11,224,032 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11711,195,599 - 11,223,821 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21713,168,730 - 13,197,126 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLAT
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1840,164,391 - 40,196,627 (-)NCBI
ChlSab1.1 Ensembl840,163,891 - 40,196,555 (-)Ensembl
Plat
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247801,014,429 - 1,063,636 (+)NCBI

Position Markers
RH40525  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37842,032,956 - 42,033,177UniSTSGRCh37
Build 36842,152,113 - 42,152,334RGDNCBI36
Celera840,981,910 - 40,982,131RGD
Cytogenetic Map8p12UniSTS
HuRef840,560,433 - 40,560,654UniSTS
GDB:176412  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37842,037,321 - 42,038,292UniSTSGRCh37
Build 36842,156,478 - 42,157,449RGDNCBI36
Celera840,986,274 - 40,987,245RGD
Cytogenetic Map8p12UniSTS
HuRef840,564,797 - 40,565,768UniSTS
GDB:185497  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37842,061,460 - 42,061,580UniSTSGRCh37
Build 36842,180,617 - 42,180,737RGDNCBI36
Celera841,010,413 - 41,010,533RGD
Cytogenetic Map8p12UniSTS
HuRef840,589,250 - 40,589,370UniSTS
GDB:185498  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37842,051,705 - 42,051,831UniSTSGRCh37
Build 36842,170,862 - 42,170,988RGDNCBI36
Celera841,000,660 - 41,000,784RGD
Cytogenetic Map8p12UniSTS
HuRef840,579,497 - 40,579,621UniSTS
GDB:186200  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37842,039,298 - 42,039,953UniSTSGRCh37
Build 36842,158,455 - 42,159,110RGDNCBI36
Celera840,988,251 - 40,988,906RGD
Cytogenetic Map8p12UniSTS
HuRef840,566,774 - 40,567,740UniSTS
GDB:386840  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37842,048,310 - 42,048,916UniSTSGRCh37
Build 36842,167,467 - 42,168,073RGDNCBI36
Celera840,997,263 - 40,997,869RGD
Cytogenetic Map8p12UniSTS
HuRef840,576,103 - 40,576,709UniSTS
PLAT_65.3  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37842,032,700 - 42,033,401UniSTSGRCh37
Build 36842,151,857 - 42,152,558RGDNCBI36
Celera840,981,654 - 40,982,355RGD
HuRef840,560,177 - 40,560,878UniSTS
NIB234  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37842,032,806 - 42,032,945UniSTSGRCh37
Build 36842,151,963 - 42,152,102RGDNCBI36
Celera840,981,760 - 40,981,899RGD
Cytogenetic Map8p12UniSTS
HuRef840,560,283 - 40,560,422UniSTS
Whitehead-YAC Contig Map8 UniSTS
D2S2567  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37842,033,461 - 42,033,567UniSTSGRCh37
Build 36842,152,618 - 42,152,724RGDNCBI36
Celera840,982,415 - 40,982,521RGD
Cytogenetic Map8p12UniSTS
HuRef840,560,938 - 40,561,044UniSTS
Stanford-G3 RH Map81759.0UniSTS
NCBI RH Map8611.0UniSTS
GeneMap99-G3 RH Map81849.0UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR21hsa-miR-21-5pOncomiRDBexternal_infoNANA21131358

Predicted Target Of
Summary Value
Count of predictions:3775
Count of miRNA genes:1041
Interacting mature miRNAs:1285
Transcripts:ENST00000220809, ENST00000270189, ENST00000352041, ENST00000429089, ENST00000429710, ENST00000519510, ENST00000520523, ENST00000521042, ENST00000521647, ENST00000521694, ENST00000522812, ENST00000524009, ENST00000524261
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 1 1 4 9 5
Medium 2310 1546 1232 174 210 42 2367 1075 2419 289 1306 1406 144 1 1157 1432 1
Low 65 772 473 433 665 405 1985 1114 1314 126 131 151 30 47 1356 4 2
Below cutoff 61 664 20 17 1057 18 8 4 14 51 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_023264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001319189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_033011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide A01465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  A03776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  A07197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC083973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC103724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF260825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF282882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH003018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH005297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK289387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK297738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK297937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK299205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY221101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY291060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC002795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC013968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC018636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC095403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT007060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX641021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS123925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS417360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D01096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA031108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA549782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC424502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM956488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  K03021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M15518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M18182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S77144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S78429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  V00570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X02901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X07393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X13097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X77531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000220809   ⟹   ENSP00000220809
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl842,174,718 - 42,207,565 (-)Ensembl
RefSeq Acc Id: ENST00000352041   ⟹   ENSP00000270188
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl842,175,237 - 42,207,676 (-)Ensembl
RefSeq Acc Id: ENST00000429089   ⟹   ENSP00000392045
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl842,175,233 - 42,207,565 (-)Ensembl
RefSeq Acc Id: ENST00000429710   ⟹   ENSP00000407861
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl842,175,747 - 42,207,565 (-)Ensembl
RefSeq Acc Id: ENST00000519510   ⟹   ENSP00000428886
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl842,175,561 - 42,207,565 (-)Ensembl
RefSeq Acc Id: ENST00000520523   ⟹   ENSP00000428797
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl842,187,401 - 42,193,727 (-)Ensembl
RefSeq Acc Id: ENST00000521042   ⟹   ENSP00000429542
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl842,180,306 - 42,187,932 (-)Ensembl
RefSeq Acc Id: ENST00000521647
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl842,184,695 - 42,188,489 (-)Ensembl
RefSeq Acc Id: ENST00000521694   ⟹   ENSP00000429801
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl842,187,465 - 42,195,698 (-)Ensembl
RefSeq Acc Id: ENST00000522812
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl842,180,083 - 42,180,764 (-)Ensembl
RefSeq Acc Id: ENST00000524009   ⟹   ENSP00000429401
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl842,175,900 - 42,207,565 (-)Ensembl
RefSeq Acc Id: ENST00000524261
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl842,182,340 - 42,185,113 (-)Ensembl
RefSeq Acc Id: ENST00000677722
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl842,175,261 - 42,207,709 (-)Ensembl
RefSeq Acc Id: ENST00000678083   ⟹   ENSP00000504824
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl842,175,233 - 42,193,467 (-)Ensembl
RefSeq Acc Id: ENST00000678676   ⟹   ENSP00000502858
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl842,175,256 - 42,207,669 (-)Ensembl
RefSeq Acc Id: ENST00000679151   ⟹   ENSP00000504311
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl842,175,233 - 42,207,690 (-)Ensembl
RefSeq Acc Id: ENST00000679300   ⟹   ENSP00000503050
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl842,175,297 - 42,207,709 (-)Ensembl
RefSeq Acc Id: NM_000930   ⟹   NP_000921
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38842,174,718 - 42,207,565 (-)NCBI
GRCh37842,032,236 - 42,065,242 (-)NCBI
Build 36842,151,393 - 42,184,351 (-)NCBI Archive
HuRef840,559,713 - 40,592,984 (-)ENTREZGENE
CHM1_1842,080,535 - 42,113,859 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001319189   ⟹   NP_001306118
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38842,174,718 - 42,207,565 (-)NCBI
CHM1_1842,080,535 - 42,113,859 (-)NCBI
Sequence:
RefSeq Acc Id: NM_033011   ⟹   NP_127509
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38842,174,718 - 42,207,565 (-)NCBI
GRCh37842,032,236 - 42,065,242 (-)NCBI
Build 36842,151,393 - 42,184,351 (-)NCBI Archive
HuRef840,559,713 - 40,592,984 (-)ENTREZGENE
CHM1_1842,080,535 - 42,113,859 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_000921 (Get FASTA)   NCBI Sequence Viewer  
  NP_001306118 (Get FASTA)   NCBI Sequence Viewer  
  NP_127509 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA36800 (Get FASTA)   NCBI Sequence Viewer  
  AAA60111 (Get FASTA)   NCBI Sequence Viewer  
  AAA61213 (Get FASTA)   NCBI Sequence Viewer  
  AAA98809 (Get FASTA)   NCBI Sequence Viewer  
  AAB59510 (Get FASTA)   NCBI Sequence Viewer  
  AAH02795 (Get FASTA)   NCBI Sequence Viewer  
  AAH07231 (Get FASTA)   NCBI Sequence Viewer  
  AAH13968 (Get FASTA)   NCBI Sequence Viewer  
  AAH18636 (Get FASTA)   NCBI Sequence Viewer  
  AAH95403 (Get FASTA)   NCBI Sequence Viewer  
  AAK11956 (Get FASTA)   NCBI Sequence Viewer  
  AAM52248 (Get FASTA)   NCBI Sequence Viewer  
  AAO34406 (Get FASTA)   NCBI Sequence Viewer  
  AAP34246 (Get FASTA)   NCBI Sequence Viewer  
  AAP35709 (Get FASTA)   NCBI Sequence Viewer  
  BAA00881 (Get FASTA)   NCBI Sequence Viewer  
  BAF82076 (Get FASTA)   NCBI Sequence Viewer  
  BAF83264 (Get FASTA)   NCBI Sequence Viewer  
  BAG36145 (Get FASTA)   NCBI Sequence Viewer  
  BAG60088 (Get FASTA)   NCBI Sequence Viewer  
  BAG60253 (Get FASTA)   NCBI Sequence Viewer  
  BAG61245 (Get FASTA)   NCBI Sequence Viewer  
  BAG62604 (Get FASTA)   NCBI Sequence Viewer  
  CAA00166 (Get FASTA)   NCBI Sequence Viewer  
  CAA00299 (Get FASTA)   NCBI Sequence Viewer  
  CAA00642 (Get FASTA)   NCBI Sequence Viewer  
  CAA23833 (Get FASTA)   NCBI Sequence Viewer  
  CAA30302 (Get FASTA)   NCBI Sequence Viewer  
  CAA31489 (Get FASTA)   NCBI Sequence Viewer  
  CAA54669 (Get FASTA)   NCBI Sequence Viewer  
  CAI46259 (Get FASTA)   NCBI Sequence Viewer  
  CAJ18783 (Get FASTA)   NCBI Sequence Viewer  
  CAL48222 (Get FASTA)   NCBI Sequence Viewer  
  CAX11668 (Get FASTA)   NCBI Sequence Viewer  
  EAW63231 (Get FASTA)   NCBI Sequence Viewer  
  EAW63232 (Get FASTA)   NCBI Sequence Viewer  
  EAW63233 (Get FASTA)   NCBI Sequence Viewer  
  EAW63234 (Get FASTA)   NCBI Sequence Viewer  
  EAW63235 (Get FASTA)   NCBI Sequence Viewer  
  P00750 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_127509   ⟸   NM_033011
- Peptide Label: isoform 3 precursor
- UniProtKB: P00750 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_000921   ⟸   NM_000930
- Peptide Label: isoform 1 preproprotein
- UniProtKB: P00750 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001306118   ⟸   NM_001319189
- Peptide Label: isoform 4 precursor
- UniProtKB: P00750 (UniProtKB/Swiss-Prot),   B4DN26 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000428886   ⟸   ENST00000519510
RefSeq Acc Id: ENSP00000392045   ⟸   ENST00000429089
RefSeq Acc Id: ENSP00000407861   ⟸   ENST00000429710
RefSeq Acc Id: ENSP00000428797   ⟸   ENST00000520523
RefSeq Acc Id: ENSP00000429542   ⟸   ENST00000521042
RefSeq Acc Id: ENSP00000429801   ⟸   ENST00000521694
RefSeq Acc Id: ENSP00000270188   ⟸   ENST00000352041
RefSeq Acc Id: ENSP00000220809   ⟸   ENST00000220809
RefSeq Acc Id: ENSP00000429401   ⟸   ENST00000524009
RefSeq Acc Id: ENSP00000504824   ⟸   ENST00000678083
RefSeq Acc Id: ENSP00000502858   ⟸   ENST00000678676
RefSeq Acc Id: ENSP00000503050   ⟸   ENST00000679300
RefSeq Acc Id: ENSP00000504311   ⟸   ENST00000679151
Protein Domains
EGF-like   Fibronectin type-I   Kringle   Peptidase S1

Promoters
RGD ID:6815668
Promoter ID:HG_MRA:15801
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:AF282882,   V00570
Position:
Human AssemblyChrPosition (strand)Source
Build 36842,159,451 - 42,159,951 (-)MPROMDB
RGD ID:6806634
Promoter ID:HG_KWN:61205
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:ENST00000270187
Position:
Human AssemblyChrPosition (strand)Source
Build 36842,165,546 - 42,166,046 (-)MPROMDB
RGD ID:6806930
Promoter ID:HG_KWN:61207
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3
Transcripts:ENST00000270189,   NM_000930,   NM_033011
Position:
Human AssemblyChrPosition (strand)Source
Build 36842,183,886 - 42,184,386 (-)MPROMDB
RGD ID:6852772
Promoter ID:EP74201
Type:multiple initiation site
Name:HS_PLAT
Description:Plasminogen activator, tissue.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:
Human AssemblyChrPosition (strand)Source
Build 36842,184,225 - 42,184,285EPD
RGD ID:7213199
Promoter ID:EPDNEW_H12345
Type:initiation region
Name:PLAT_1
Description:plasminogen activator, tissue type
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38842,207,676 - 42,207,736EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 8p12-q11.21(chr8:29719897-48521849)x3 copy number gain See cases [RCV000050995] Chr8:29719897..48521849 [GRCh38]
Chr8:29577413..49434409 [GRCh37]
Chr8:29633332..49596962 [NCBI36]
Chr8:8p12-q11.21
pathogenic
GRCh38/hg38 8p21.2-q11.21(chr8:25832130-48521849)x3 copy number gain See cases [RCV000050904] Chr8:25832130..48521849 [GRCh38]
Chr8:25689646..49434409 [GRCh37]
Chr8:25745563..49596962 [NCBI36]
Chr8:8p21.2-q11.21
pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12728904-43673207)x3 copy number gain See cases [RCV000050912] Chr8:12728904..43673207 [GRCh38]
Chr8:12586413..43528350 [GRCh37]
Chr8:12630784..43647507 [NCBI36]
Chr8:8p23.1-11.1
pathogenic
GRCh38/hg38 8p12-11.21(chr8:34312250-43158901)x1 copy number loss See cases [RCV000050745] Chr8:34312250..43158901 [GRCh38]
Chr8:34169768..43014044 [GRCh37]
Chr8:34289310..43133201 [NCBI36]
Chr8:8p12-11.21
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p11.21(chr8:42037723-42900363)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052169]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052169]|See cases [RCV000052169] Chr8:42037723..42900363 [GRCh38]
Chr8:41895241..42755506 [GRCh37]
Chr8:42014398..42874663 [NCBI36]
Chr8:8p11.21
uncertain significance
GRCh38/hg38 8p23.1-11.1(chr8:12609975-43336172)x3 copy number gain See cases [RCV000053630] Chr8:12609975..43336172 [GRCh38]
Chr8:12467484..43191315 [GRCh37]
Chr8:12511855..43310472 [NCBI36]
Chr8:8p23.1-11.1
pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12609975-43255410)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053631]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053631]|See cases [RCV000053631] Chr8:12609975..43255410 [GRCh38]
Chr8:12467484..43110553 [GRCh37]
Chr8:12511855..43229710 [NCBI36]
Chr8:8p23.1-11.1
pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12750796-43532444)x3 copy number gain See cases [RCV000053632] Chr8:12750796..43532444 [GRCh38]
Chr8:12608305..43387587 [GRCh37]
Chr8:12652676..43506744 [NCBI36]
Chr8:8p23.1-11.1
pathogenic
GRCh38/hg38 8p22-q11.21(chr8:14940110-47929925)x3 copy number gain See cases [RCV000053635] Chr8:14940110..47929925 [GRCh38]
Chr8:14797619..48842485 [GRCh37]
Chr8:14841990..49005038 [NCBI36]
Chr8:8p22-q11.21
pathogenic
GRCh38/hg38 8p11.23-11.21(chr8:37899430-42371734)x3 copy number gain See cases [RCV000053648] Chr8:37899430..42371734 [GRCh38]
Chr8:37756948..42229252 [GRCh37]
Chr8:37876106..42348409 [NCBI36]
Chr8:8p11.23-11.21
pathogenic
GRCh38/hg38 8p11.22-q11.21(chr8:39830633-49209461)x3 copy number gain See cases [RCV000053649] Chr8:39830633..49209461 [GRCh38]
Chr8:39688152..50122020 [GRCh37]
Chr8:39807309..50284573 [NCBI36]
Chr8:8p11.22-q11.21
pathogenic
GRCh38/hg38 8p11.21-11.1(chr8:39981424-43532444)x3 copy number gain See cases [RCV000053650] Chr8:39981424..43532444 [GRCh38]
Chr8:39838943..43387587 [GRCh37]
Chr8:39958100..43506744 [NCBI36]
Chr8:8p11.21-11.1
pathogenic
GRCh38/hg38 8p11.21-q11.21(chr8:41547961-48178799)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053651]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053651]|See cases [RCV000053651] Chr8:41547961..48178799 [GRCh38]
Chr8:41405480..49091359 [GRCh37]
Chr8:41524637..49253912 [NCBI36]
Chr8:8p11.21-q11.21
pathogenic
GRCh38/hg38 8p11.21-q11.21(chr8:41845699-47893948)x3 copy number gain See cases [RCV000053652] Chr8:41845699..47893948 [GRCh38]
Chr8:41703217..48806508 [GRCh37]
Chr8:41822374..48969061 [NCBI36]
Chr8:8p11.21-q11.21
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p12-q24.3(chr8:31936551-146295771)x3 copy number gain not provided [RCV000848192] Chr8:31936551..146295771 [GRCh37]
Chr8:8p12-q24.3
pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12609975-43673207)x3 copy number gain See cases [RCV000135786] Chr8:12609975..43673207 [GRCh38]
Chr8:12467484..43528350 [GRCh37]
Chr8:12511855..43647507 [NCBI36]
Chr8:8p23.1-11.1
pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12383584-43673207)x3 copy number gain See cases [RCV000135566] Chr8:12383584..43673207 [GRCh38]
Chr8:12241093..43528350 [GRCh37]
Chr8:12285464..43647507 [NCBI36]
Chr8:8p23.1-11.1
pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12182421-43673207)x3 copy number gain See cases [RCV000137249] Chr8:12182421..43673207 [GRCh38]
Chr8:12039930..43528350 [GRCh37]
Chr8:12077339..43647507 [NCBI36]
Chr8:8p23.1-11.1
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12646123-43686843)x3 copy number gain See cases [RCV000139796] Chr8:12646123..43686843 [GRCh38]
Chr8:12503632..43541986 [GRCh37]
Chr8:12548003..43661143 [NCBI36]
Chr8:8p23.1-11.1
pathogenic
GRCh38/hg38 8p12-q12.1(chr8:36580103-59618998)x3 copy number gain See cases [RCV000139582] Chr8:36580103..59618998 [GRCh38]
Chr8:36437621..60531557 [GRCh37]
Chr8:36556779..60694111 [NCBI36]
Chr8:8p12-q12.1
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p11.21-11.1(chr8:39960531-43673207)x3 copy number gain See cases [RCV000142663] Chr8:39960531..43673207 [GRCh38]
Chr8:39818050..43528350 [GRCh37]
Chr8:39937207..43647507 [NCBI36]
Chr8:8p11.21-11.1
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12728904-43673207)x3 copy number gain See cases [RCV000148237] Chr8:12728904..43673207 [GRCh38]
Chr8:12586413..43528350 [GRCh37]
Chr8:12630784..43647507 [NCBI36]
Chr8:8p23.1-11.1
pathogenic
NM_000930.5(PLAT):c.102_103del (p.Arg35fs) deletion not provided [RCV000258825] Chr8:42191384..42191385 [GRCh38]
Chr8:42048902..42048903 [GRCh37]
Chr8:8p11.21
uncertain significance
GRCh37/hg19 8p11.21-11.1(chr8:40690198-43388233)x3 copy number gain See cases [RCV000446823] Chr8:40690198..43388233 [GRCh37]
Chr8:8p11.21-11.1
pathogenic
GRCh37/hg19 8p21.2-q12.1(chr8:24772064-24813176)x3 copy number gain See cases [RCV000446588] Chr8:24772064..24813176 [GRCh37]
Chr8:8p21.2-q12.1
uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:158991-146280828)x3 copy number gain See cases [RCV000447507] Chr8:158991..146280828 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-11.1(chr8:158048-43786723)x3 copy number gain See cases [RCV000447909] Chr8:158048..43786723 [GRCh37]
Chr8:8p23.3-11.1
pathogenic
GRCh37/hg19 8p23.1-11.1(chr8:12580132-43388233)x3 copy number gain See cases [RCV000447913] Chr8:12580132..43388233 [GRCh37]
Chr8:8p23.1-11.1
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771) copy number gain See cases [RCV000510234] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.1-11.1(chr8:11935023-43824035)x3 copy number gain See cases [RCV000511028] Chr8:11935023..43824035 [GRCh37]
Chr8:8p23.1-11.1
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)x3 copy number gain See cases [RCV000511095] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.1-q24.3(chr8:12490999-146295771)x3 copy number gain See cases [RCV000512169] Chr8:12490999..146295771 [GRCh37]
Chr8:8p23.1-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:164984-146293414)x3 copy number gain not provided [RCV000747254] Chr8:164984..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:10213-146293414)x3 copy number gain not provided [RCV000747248] Chr8:10213..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
NM_000930.5(PLAT):c.57C>T (p.Phe19=) single nucleotide variant not provided [RCV000927952] Chr8:42193129 [GRCh38]
Chr8:42050647 [GRCh37]
Chr8:8p11.21
likely benign
NM_000930.5(PLAT):c.1479T>A (p.Ala493=) single nucleotide variant not provided [RCV000884823] Chr8:42178948 [GRCh38]
Chr8:42036466 [GRCh37]
Chr8:8p11.21
benign
NM_000930.5(PLAT):c.435C>T (p.Gly145=) single nucleotide variant not provided [RCV000900669] Chr8:42187502 [GRCh38]
Chr8:42045020 [GRCh37]
Chr8:8p11.21
likely benign
NM_000930.5(PLAT):c.573C>T (p.Tyr191=) single nucleotide variant not provided [RCV000983030] Chr8:42185139 [GRCh38]
Chr8:42042657 [GRCh37]
Chr8:8p11.21
likely benign
NM_000930.5(PLAT):c.1629G>A (p.Pro543=) single nucleotide variant not provided [RCV000883924] Chr8:42176053 [GRCh38]
Chr8:42033571 [GRCh37]
Chr8:8p11.21
likely benign
NM_000930.5(PLAT):c.1167C>G (p.Val389=) single nucleotide variant not provided [RCV000947106] Chr8:42180297 [GRCh38]
Chr8:42037815 [GRCh37]
Chr8:8p11.21
benign
NM_000930.5(PLAT):c.837C>T (p.His279=) single nucleotide variant not provided [RCV000902940] Chr8:42181989 [GRCh38]
Chr8:42039507 [GRCh37]
Chr8:8p11.21
benign
NM_000930.5(PLAT):c.1167C>A (p.Val389=) single nucleotide variant not provided [RCV000965075] Chr8:42180297 [GRCh38]
Chr8:42037815 [GRCh37]
Chr8:8p11.21
benign
NM_000930.5(PLAT):c.860C>T (p.Thr287Met) single nucleotide variant not provided [RCV000952555] Chr8:42181966 [GRCh38]
Chr8:42039484 [GRCh37]
Chr8:8p11.21
likely benign|conflicting interpretations of pathogenicity
NM_000930.5(PLAT):c.861G>A (p.Thr287=) single nucleotide variant not provided [RCV000955186] Chr8:42181965 [GRCh38]
Chr8:42039483 [GRCh37]
Chr8:8p11.21
benign
NM_000930.5(PLAT):c.462C>T (p.Ser154=) single nucleotide variant not provided [RCV000922464] Chr8:42187475 [GRCh38]
Chr8:42044993 [GRCh37]
Chr8:8p11.21
likely benign
NM_000930.5(PLAT):c.585G>C (p.Ala195=) single nucleotide variant not provided [RCV000919781] Chr8:42185127 [GRCh38]
Chr8:42042645 [GRCh37]
Chr8:8p11.21
likely benign
NM_000930.5(PLAT):c.1173A>G (p.Lys391=) single nucleotide variant not provided [RCV000931932] Chr8:42180291 [GRCh38]
Chr8:42037809 [GRCh37]
Chr8:8p11.21
likely benign
NM_000930.5(PLAT):c.1131G>A (p.Arg377=) single nucleotide variant not provided [RCV000924428] Chr8:42180333 [GRCh38]
Chr8:42037851 [GRCh37]
Chr8:8p11.21
likely benign
NM_000930.5(PLAT):c.690C>T (p.Thr230=) single nucleotide variant not provided [RCV000891535] Chr8:42182832 [GRCh38]
Chr8:42040350 [GRCh37]
Chr8:8p11.21
benign
GRCh37/hg19 8p11.21(chr8:41761813-42107108)x1 copy number loss not provided [RCV000848394] Chr8:41761813..42107108 [GRCh37]
Chr8:8p11.21
pathogenic
NM_000930.5(PLAT):c.614C>A (p.Thr205Asn) single nucleotide variant not provided [RCV000916235] Chr8:42185098 [GRCh38]
Chr8:42042616 [GRCh37]
Chr8:8p11.21
likely benign
GRCh37/hg19 8p11.22-q12.3(chr8:39555657-64049089)x3 copy number gain not provided [RCV000846266] Chr8:39555657..64049089 [GRCh37]
Chr8:8p11.22-q12.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not provided [RCV000848478] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
NM_000930.5(PLAT):c.1271G>T (p.Ser424Ile) single nucleotide variant Deep venous thrombosis [RCV000851678] Chr8:42180018 [GRCh38]
Chr8:42037536 [GRCh37]
Chr8:8p11.21
uncertain significance
NM_000930.5(PLAT):c.1481G>C (p.Gly494Ala) single nucleotide variant Abnormal bleeding [RCV001270618]|not provided [RCV000999031] Chr8:42178946 [GRCh38]
Chr8:42036464 [GRCh37]
Chr8:8p11.21
uncertain significance
NM_000930.5(PLAT):c.486C>T (p.Ser162=) single nucleotide variant not provided [RCV000999032] Chr8:42187451 [GRCh38]
Chr8:42044969 [GRCh37]
Chr8:8p11.21
uncertain significance
GRCh37/hg19 8p12-11.1(chr8:36094421-43822214)x3 copy number gain not provided [RCV000848822] Chr8:36094421..43822214 [GRCh37]
Chr8:8p12-11.1
uncertain significance
NM_000930.5(PLAT):c.826C>T (p.Pro276Ser) single nucleotide variant Deep venous thrombosis [RCV000852234] Chr8:42182000 [GRCh38]
Chr8:42039518 [GRCh37]
Chr8:8p11.21
uncertain significance
NM_000930.5(PLAT):c.101C>A (p.Ala34Asp) single nucleotide variant not provided [RCV000885945] Chr8:42191386 [GRCh38]
Chr8:42048904 [GRCh37]
Chr8:8p11.21
likely benign
NM_000930.5(PLAT):c.414G>A (p.Thr138=) single nucleotide variant not provided [RCV000917474] Chr8:42187523 [GRCh38]
Chr8:42045041 [GRCh37]
Chr8:8p11.21
likely benign
NM_000930.5(PLAT):c.1539G>A (p.Ser513=) single nucleotide variant not provided [RCV000879226] Chr8:42176143 [GRCh38]
Chr8:42033661 [GRCh37]
Chr8:8p11.21
benign
NM_000930.5(PLAT):c.1411T>C (p.Tyr471His) single nucleotide variant not provided [RCV000908801] Chr8:42179016 [GRCh38]
Chr8:42036534 [GRCh37]
Chr8:8p11.21
likely benign
NM_000930.5(PLAT):c.1681C>T (p.Arg561Ter) single nucleotide variant not provided [RCV000889033] Chr8:42176001 [GRCh38]
Chr8:42033519 [GRCh37]
Chr8:8p11.21
benign
NM_000930.5(PLAT):c.1251C>T (p.Ser417=) single nucleotide variant not provided [RCV000934680] Chr8:42180038 [GRCh38]
Chr8:42037556 [GRCh37]
Chr8:8p11.21
likely benign
NM_000930.5(PLAT):c.1323_1325delinsTAT (p.Trp441_Thr442delinsCysMet) indel Hereditary angioedema with normal C1Inh [RCV001027419] Chr8:42179964..42179966 [GRCh38]
Chr8:42037482..42037484 [GRCh37]
Chr8:8p11.21
not provided
NM_000930.5(PLAT):c.928C>T (p.Arg310Cys) single nucleotide variant Abnormal bleeding [RCV001270582] Chr8:42180647 [GRCh38]
Chr8:42038165 [GRCh37]
Chr8:8p11.21
uncertain significance
GRCh37/hg19 8p23.3-11.1(chr8:176814-43396776) copy number gain Abnormality of the fetal cardiovascular system [RCV001291977] Chr8:176814..43396776 [GRCh37]
Chr8:8p23.3-11.1
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9051 AgrOrtholog
COSMIC PLAT COSMIC
Ensembl Genes ENSG00000104368 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000220809 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000270188 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000392045 UniProtKB/Swiss-Prot
  ENSP00000407861 UniProtKB/TrEMBL
  ENSP00000428797 UniProtKB/TrEMBL
  ENSP00000428886 UniProtKB/TrEMBL
  ENSP00000429401 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000429542 UniProtKB/TrEMBL
  ENSP00000429801 UniProtKB/TrEMBL
Ensembl Transcript ENST00000220809 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000352041 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000429089 UniProtKB/Swiss-Prot
  ENST00000429710 UniProtKB/TrEMBL
  ENST00000519510 UniProtKB/TrEMBL
  ENST00000520523 UniProtKB/TrEMBL
  ENST00000521042 UniProtKB/TrEMBL
  ENST00000521694 UniProtKB/TrEMBL
  ENST00000524009 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.40.20.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000104368 GTEx
HGNC ID HGNC:9051 ENTREZGENE
Human Proteome Map PLAT Human Proteome Map
InterPro EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fibronectin_type1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tissue_plasm_act UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  tPA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5327 UniProtKB/Swiss-Prot
NCBI Gene 5327 ENTREZGENE
OMIM 173370 OMIM
  612348 OMIM
PANTHER PTHR24264:SF42 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  fn1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA33381 PharmGKB
PIRSF Tissue_plasm_act UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KRINGLE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KRINGLE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FN1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00130 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57440 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B4DN26 ENTREZGENE, UniProtKB/TrEMBL
  B4DNJ1_HUMAN UniProtKB/TrEMBL
  B8ZX62_HUMAN UniProtKB/TrEMBL
  E5RGA1_HUMAN UniProtKB/TrEMBL
  E5RHG4_HUMAN UniProtKB/TrEMBL
  E7ESF4_HUMAN UniProtKB/TrEMBL
  H0YBH9_HUMAN UniProtKB/TrEMBL
  P00750 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A8K022 UniProtKB/Swiss-Prot
  B2R8E8 UniProtKB/Swiss-Prot
  Q15103 UniProtKB/Swiss-Prot
  Q503B0 UniProtKB/Swiss-Prot
  Q6PJA5 UniProtKB/Swiss-Prot
  Q7Z7N2 UniProtKB/Swiss-Prot
  Q86YK8 UniProtKB/Swiss-Prot
  Q9BU99 UniProtKB/Swiss-Prot
  Q9BZW1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-19 PLAT  plasminogen activator, tissue type    plasminogen activator, tissue  Symbol and/or name change 5135510 APPROVED
2011-08-16 PLAT  plasminogen activator, tissue  PLAT  plasminogen activator, tissue  Symbol and/or name change 5135510 APPROVED