Mag (myelin-associated glycoprotein) - Rat Genome Database

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Gene: Mag (myelin-associated glycoprotein) Rattus norvegicus
Analyze
Symbol: Mag
Name: myelin-associated glycoprotein
RGD ID: 3035
Description: Enables carboxylic acid binding activity; protein kinase binding activity; and signaling receptor binding activity. Involved in several processes, including cellular response to mechanical stimulus; negative regulation of neuron differentiation; and regulation of neurogenesis. Located in several cellular components, including Schmidt-Lanterman incisure; mesaxon; and myelin sheath adaxonal region. Used to study middle cerebral artery infarction and sciatic neuropathy. Biomarker of nerve compression syndrome. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 75. Orthologous to human MAG (myelin associated glycoprotein); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 1B236; brain neuron cytoplasmic protein 3; S-MAG (C-term.); sialic acid-binding Ig-like lectin 4a; siglec-4a
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2186,148,227 - 86,163,726 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl186,148,228 - 86,163,656 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx191,568,489 - 91,583,766 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01100,034,659 - 100,049,930 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0193,326,789 - 93,342,064 (-)NCBIRnor_WKY
Rnor_6.0189,345,325 - 89,360,905 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl189,345,429 - 89,360,733 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0190,500,932 - 90,516,312 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4185,954,511 - 85,970,832 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1186,032,629 - 86,048,943 (-)NCBI
Celera180,517,171 - 80,532,485 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Molecular cloning and primary structure of myelin-associated glycoprotein. Arquint M, etal., Proc Natl Acad Sci U S A 1987 Jan;84(2):600-4.
2. Sequential loss of myelin proteins during Wallerian degeneration in the rat spinal cord. Buss A and Schwab ME, Glia. 2003 Jun;42(4):424-32.
3. Sialic acid specificity of myelin-associated glycoprotein binding. Collins BE, etal., J Biol Chem. 1997 Jan 10;272(2):1248-55.
4. Myelin-associated glycoprotein interacts with the Nogo66 receptor to inhibit neurite outgrowth. Domeniconi M, etal., Neuron 2002 Jul 18;35(2):283-90.
5. Microtubule-associated protein 1B: a neuronal binding partner for myelin-associated glycoprotein. Franzen R, etal., J Cell Biol. 2001 Dec 10;155(6):893-8. Epub 2001 Dec 3.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Local down-regulation of myelin-associated glycoprotein permits axonal sprouting with chronic nerve compression injury. Gupta R, etal., Exp Neurol. 2006 Aug;200(2):418-29. Epub 2006 Jun 9.
8. Shear stress alters the expression of myelin-associated glycoprotein (MAG) and myelin basic protein (MBP) in Schwann cells. Gupta R, etal., J Orthop Res. 2005 Sep;23(5):1232-9. Epub 2005 Apr 25.
9. Promotion of axon regeneration by myelin-associated glycoprotein and Nogo through divergent signals downstream of Gi/G. Hasegawa Y, etal., J Neurosci. 2004 Jul 28;24(30):6826-32.
10. Identification of neuroprotective properties of anti-MAG antibody: a novel approach for the treatment of stroke? Irving EA, etal., J Cereb Blood Flow Metab. 2005 Jan;25(1):98-107.
11. Quantitation of the myelin-associated glycoprotein in human nervous tissue from controls and multiple sclerosis patients. Johnson D, etal., J Neurochem. 1986 Apr;46(4):1086-93.
12. Two forms of 1B236/myelin-associated glycoprotein, a cell adhesion molecule for postnatal neural development, are produced by alternative splicing. Lai C, etal., Proc Natl Acad Sci U S A 1987 Jun;84(12):4337-41.
13. Myelin-associated glycoprotein inhibits the neuronal differentiation of neural progenitors. Li X, etal., Neuroreport. 2009 May 6;20(7):708-12. doi: 10.1097/WNR.0b013e32832aa942.
14. Alterations of myelin proteins in inflammatory demyelination of BALB/c mice caused by Angiostrongylus cantonensis. Lin KY, etal., Vet Parasitol. 2010 Jul 15;171(1-2):74-80. doi: 10.1016/j.vetpar.2010.03.019. Epub 2010 Mar 30.
15. Gangliosides and Nogo receptors independently mediate myelin-associated glycoprotein inhibition of neurite outgrowth in different nerve cells. Mehta NR, etal., J Biol Chem. 2007 Sep 21;282(38):27875-86. Epub 2007 Jul 19.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Secreted glycoprotein myocilin is a component of the myelin sheath in peripheral nerves. Ohlmann A, etal., Glia. 2003 Aug;43(2):128-40.
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. Expression of recombinant myelin-associated glycoprotein in primary Schwann cells promotes the initial investment of axons by myelinating Schwann cells. Owens GC, etal., J Cell Biol. 1990 Sep;111(3):1171-82.
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Molecular basis of the interactions of the Nogo-66 receptor and its homolog NgR2 with myelin-associated glycoprotein: development of NgROMNI-Fc, a novel antagonist of CNS myelin inhibition. Robak LA, etal., J Neurosci. 2009 May 6;29(18):5768-83. doi: 10.1523/JNEUROSCI.4935-08.2009.
24. The amino acid sequences of the myelin-associated glycoproteins: homology to the immunoglobulin gene superfamily. Salzer JL, etal., J Cell Biol 1987 Apr;104(4):957-65.
25. Opioid addiction and pregnancy: perinatal exposure to buprenorphine affects myelination in the developing brain. Sanchez ES, etal., Glia. 2008 Jul;56(9):1017-27. doi: 10.1002/glia.20675.
26. Putative role of calpain in the pathophysiology of experimental optic neuritis. Shields DC and Banik NL, Exp Eye Res. 1998 Oct;67(4):403-10.
27. Myelin-associated glycoprotein demonstrated immunocytochemically in myelin and myelin-forming cells of developing rat. Sternberger NH, etal., Proc Natl Acad Sci U S A. 1979 Mar;76(3):1510-4.
28. LDL receptor-related protein-1 is a sialic-acid-independent receptor for myelin-associated glycoprotein that functions in neurite outgrowth inhibition by MAG and CNS myelin. Stiles TL, etal., J Cell Sci. 2013 Jan 1;126(Pt 1):209-20. doi: 10.1242/jcs.113191. Epub 2012 Nov 6.
29. Identifying the protein products of brain-specific genes with antibodies to chemically synthesized peptides. Sutcliffe JG, etal., Cell 1983 Jul;33(3):671-82.
30. Cellular localization and function of the proteins encoded by brain-specific mRNAs. Sutcliffe JG, etal., Cold Spring Harb Symp Quant Biol 1983;48 Pt 2:477-84.
31. Myelin-associated glycoprotein interacts with neurons via a sialic acid binding site at ARG118 and a distinct neurite inhibition site. Tang S, etal., J Cell Biol. 1997 Sep 22;138(6):1355-66.
32. Tissue sparing and functional recovery following experimental traumatic brain injury is provided by treatment with an anti-myelin-associated glycoprotein antibody. Thompson HJ, etal., Eur J Neurosci. 2006 Dec;24(11):3063-72.
33. Myelin-associated glycoprotein reduces axonal branching and enhances functional recovery after sciatic nerve transection in rats. Tomita K, etal., Glia. 2007 Nov 1;55(14):1498-507.
34. Differential splicing of MAG transcripts during CNS and PNS development. Tropak MB, etal., Brain Res. 1988 Sep;464(2):143-55.
35. The Nogo-66 receptor homolog NgR2 is a sialic acid-dependent receptor selective for myelin-associated glycoprotein. Venkatesh K, etal., J Neurosci. 2005 Jan 26;25(4):808-22.
Additional References at PubMed
PMID:1703542   PMID:2457152   PMID:4020419   PMID:6200494   PMID:9482783   PMID:10625334   PMID:11283023   PMID:12691736   PMID:12718855   PMID:12975355   PMID:16595691   PMID:17497667  
PMID:17634366   PMID:18922173   PMID:20071523   PMID:20308067   PMID:20731761   PMID:22871113   PMID:22926577   PMID:24101522   PMID:24129569   PMID:26179919   PMID:26335717   PMID:27583434  
PMID:27922006   PMID:29476059   PMID:31985825   PMID:32357304  


Genomics

Comparative Map Data
Mag
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2186,148,227 - 86,163,726 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl186,148,228 - 86,163,656 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx191,568,489 - 91,583,766 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01100,034,659 - 100,049,930 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0193,326,789 - 93,342,064 (-)NCBIRnor_WKY
Rnor_6.0189,345,325 - 89,360,905 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl189,345,429 - 89,360,733 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0190,500,932 - 90,516,312 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4185,954,511 - 85,970,832 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1186,032,629 - 86,048,943 (-)NCBI
Celera180,517,171 - 80,532,485 (-)NCBICelera
Cytogenetic Map1q21NCBI
MAG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381935,292,161 - 35,313,807 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1935,292,125 - 35,313,807 (+)EnsemblGRCh38hg38GRCh38
GRCh371935,783,064 - 35,804,710 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361940,474,878 - 40,496,547 (+)NCBINCBI36Build 36hg18NCBI36
Build 341940,474,877 - 40,496,547NCBI
Celera1932,496,476 - 32,518,142 (+)NCBICelera
Cytogenetic Map19q13.12NCBI
HuRef1932,291,486 - 32,313,186 (+)NCBIHuRef
CHM1_11935,784,610 - 35,806,322 (+)NCBICHM1_1
T2T-CHM13v2.01937,836,825 - 37,858,521 (+)NCBIT2T-CHM13v2.0
Mag
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39730,598,600 - 30,614,347 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl730,598,601 - 30,614,298 (-)EnsemblGRCm39 Ensembl
GRCm38730,899,175 - 30,914,922 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl730,899,176 - 30,914,873 (-)EnsemblGRCm38mm10GRCm38
MGSCv37731,684,202 - 31,699,851 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36730,607,943 - 30,623,592 (-)NCBIMGSCv36mm8
Celera725,483,485 - 25,499,089 (-)NCBICelera
Cytogenetic Map7B1NCBI
cM Map719.26NCBI
Mag
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554684,584,162 - 4,598,914 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554684,584,068 - 4,598,772 (+)NCBIChiLan1.0ChiLan1.0
MAG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11940,975,763 - 40,997,401 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1940,975,763 - 40,997,401 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01932,238,457 - 32,260,497 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MAG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11117,288,306 - 117,301,975 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1117,288,343 - 117,302,386 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1116,691,276 - 116,704,898 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01117,888,249 - 117,901,841 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1117,861,538 - 117,902,800 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11117,450,999 - 117,464,593 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01117,076,835 - 117,090,444 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01118,132,334 - 118,145,991 (-)NCBIUU_Cfam_GSD_1.0
Mag
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934910,640,975 - 10,656,139 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936570989,743 - 1,004,820 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl644,794,204 - 44,809,926 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1644,794,197 - 44,809,933 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2640,214,125 - 40,221,021 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1630,224,873 - 30,246,277 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl630,227,442 - 30,246,481 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660737,998,988 - 8,036,095 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mag
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247948,236,223 - 8,258,361 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247948,237,005 - 8,251,933 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mag
51 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:702
Count of miRNA genes:242
Interacting mature miRNAs:290
Transcripts:ENSRNOT00000028544, ENSRNOT00000044532
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat

Markers in Region
UniSTS:143817  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2186,148,501 - 86,148,630 (+)MAPPERmRatBN7.2
Rnor_6.0189,345,600 - 89,345,728NCBIRnor6.0
Rnor_5.0190,501,113 - 90,501,241UniSTSRnor5.0
RGSC_v3.4185,954,692 - 85,954,820UniSTSRGSC3.4
Celera180,517,352 - 80,517,480UniSTS
Cytogenetic Map1q21UniSTS
RH134668  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2186,148,556 - 86,148,768 (+)MAPPERmRatBN7.2
Rnor_6.0189,345,655 - 89,345,866NCBIRnor6.0
Rnor_5.0190,501,168 - 90,501,379UniSTSRnor5.0
RGSC_v3.4185,954,747 - 85,954,958UniSTSRGSC3.4
Celera180,517,407 - 80,517,618UniSTS
RH 3.4 Map1843.3UniSTS
Cytogenetic Map1q21UniSTS
Mag  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2186,148,427 - 86,148,671 (+)MAPPERmRatBN7.2
Rnor_6.0189,345,526 - 89,345,769NCBIRnor6.0
Rnor_5.0190,501,039 - 90,501,282UniSTSRnor5.0
RGSC_v3.4185,954,618 - 85,954,861UniSTSRGSC3.4
Celera180,517,278 - 80,517,521UniSTS
Cytogenetic Map1q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 29
Low 6 3 2 2 6 6 23 20 3 6
Below cutoff 2 18 37 22 13 22 2 4 10 22 19 7 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_017190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006228824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006228827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC111870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M11721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M14871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M16800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M22357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M36702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  V01544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X05301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X06554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X63419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000028544   ⟹   ENSRNOP00000028544
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl186,148,331 - 86,163,640 (-)Ensembl
Rnor_6.0 Ensembl189,345,429 - 89,360,733 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000044532   ⟹   ENSRNOP00000041373
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl186,148,228 - 86,163,656 (-)Ensembl
Rnor_6.0 Ensembl189,345,748 - 89,358,166 (-)Ensembl
RefSeq Acc Id: NM_017190   ⟹   NP_058886
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2186,148,321 - 86,163,640 (-)NCBI
Rnor_6.0189,345,419 - 89,360,733 (-)NCBI
Rnor_5.0190,500,932 - 90,516,312 (-)NCBI
RGSC_v3.4185,954,511 - 85,970,832 (-)RGD
Celera180,517,171 - 80,532,485 (-)RGD
Sequence:
RefSeq Acc Id: XM_006228824   ⟹   XP_006228886
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2186,148,227 - 86,163,718 (-)NCBI
Rnor_6.0189,345,325 - 89,360,904 (-)NCBI
Rnor_5.0190,500,932 - 90,516,312 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006228827   ⟹   XP_006228889
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2186,148,227 - 86,163,654 (-)NCBI
Rnor_6.0189,345,325 - 89,360,905 (-)NCBI
Rnor_5.0190,500,932 - 90,516,312 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008759138   ⟹   XP_008757360
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2186,148,227 - 86,163,726 (-)NCBI
Rnor_6.0189,345,325 - 89,360,904 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017589051   ⟹   XP_017444540
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2186,148,227 - 86,163,666 (-)NCBI
Rnor_6.0189,345,325 - 89,360,905 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017589054   ⟹   XP_017444543
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2186,148,258 - 86,163,718 (-)NCBI
Rnor_6.0189,345,500 - 89,360,902 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_058886   ⟸   NM_017190
- Peptide Label: precursor
- UniProtKB: P07723 (UniProtKB/Swiss-Prot),   P07722 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006228886   ⟸   XM_006228824
- Peptide Label: isoform X1
- UniProtKB: P07723 (UniProtKB/Swiss-Prot),   P07722 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006228889   ⟸   XM_006228827
- Peptide Label: isoform X2
- UniProtKB: G3V9B3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008757360   ⟸   XM_008759138
- Peptide Label: isoform X1
- UniProtKB: P07723 (UniProtKB/Swiss-Prot),   P07722 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017444540   ⟸   XM_017589051
- Peptide Label: isoform X1
- UniProtKB: P07723 (UniProtKB/Swiss-Prot),   P07722 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017444543   ⟸   XM_017589054
- Peptide Label: isoform X2
- UniProtKB: G3V9B3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000028544   ⟸   ENSRNOT00000028544
RefSeq Acc Id: ENSRNOP00000041373   ⟸   ENSRNOT00000044532
Protein Domains
Ig-like   Ig-like C2-type   Ig-like V-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P07722-F1-model_v2 AlphaFold P07722 1-626 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689935
Promoter ID:EPDNEW_R459
Type:initiation region
Name:Mag_1
Description:myelin-associated glycoprotein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0189,360,759 - 89,360,819EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3035 AgrOrtholog
BioCyc Gene G2FUF-60063 BioCyc
Ensembl Genes ENSRNOG00000021023 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000028544 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000041373 ENTREZGENE
  ENSRNOP00000041373.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028544 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000044532 ENTREZGENE
  ENSRNOT00000044532.6 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CD80_C2-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29409 UniProtKB/Swiss-Prot
NCBI Gene 29409 ENTREZGENE
Pfam C2-set_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mag PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IGc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt G3V9B3 ENTREZGENE, UniProtKB/TrEMBL
  MAG_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P07723 ENTREZGENE
UniProt Secondary P02685 UniProtKB/Swiss-Prot
  P07723 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Mag  Myelin-associated glycoprotein      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_transcript has two alternative splice products 728945