RGD Reference Report - Alterations of myelin proteins in inflammatory demyelination of BALB/c mice caused by Angiostrongylus cantonensis. - Rat Genome Database

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Alterations of myelin proteins in inflammatory demyelination of BALB/c mice caused by Angiostrongylus cantonensis.

Authors: Lin, K Y  Chen, K M  Lan, K P  Lee, H H  Lai, S C 
Citation: Lin KY, etal., Vet Parasitol. 2010 Jul 15;171(1-2):74-80. doi: 10.1016/j.vetpar.2010.03.019. Epub 2010 Mar 30.
RGD ID: 27226693
Pubmed: PMID:20399564   (View Abstract at PubMed)
DOI: DOI:10.1016/j.vetpar.2010.03.019   (Journal Full-text)

Angiostrongylus cantonensis causes eosinophilic meningitis or meningoencephalitis, yet little is known about demyelination caused by this parasite. To define the course of demyelination caused by A. cantonensis, we analyzed the expression of myelin proteins including myelin-associated glycoprotein (MAG), myelin basic protein (MBP), myelin-associated oligodendrocytic basic protein (MOBP), and proteolipid protein (PLP) in brain and cerebrospinal fluid (CSF)-like fluid of infected and uninfected BALB/c mice. In A. cantonensis-infected mice, the expression of MAG, MBP, MOBP, and PLP mRNAs in brain tissue was decreased, while expression of the corresponding proteins was significantly increased in CSF-like fluid. Light microscopy revealed perivascular infiltrates in the brain during meningoencephalitis, suggesting that the cause of demyelination in angiostrongyliasis was immune system attack on the oligodendrocytic myelin sheath and subsequent release of myelin proteins into the CSF. Thus, intracerebral myelin breakdown in angiostrongyliasis may be a response to inflammatory mediators and the cause of increased myelin proteins in the CSF-like fluid.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
angiostrongyliasis disease_progressionISOMag (Mus musculus)27226693; 27226693 RGD 
angiostrongyliasis disease_progressionISOMbp (Mus musculus)27226693; 27226693 RGD 
angiostrongyliasis disease_progressionISOMobp (Mus musculus)27226693; 27226693 RGD 
angiostrongyliasis disease_progressionIEP 27226693; 27226693; 27226693 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mag  (myelin-associated glycoprotein)
Mbp  (myelin basic protein)
Mobp  (myelin-associated oligodendrocyte basic protein)

Genes (Mus musculus)
Mag  (myelin-associated glycoprotein)
Mbp  (myelin basic protein)
Mobp  (myelin-associated oligodendrocytic basic protein)

Genes (Homo sapiens)
MAG  (myelin associated glycoprotein)
MBP  (myelin basic protein)
MOBP  (myelin associated oligodendrocyte basic protein)


Additional Information