RGD Reference Report - Myelin-associated glycoprotein demonstrated immunocytochemically in myelin and myelin-forming cells of developing rat. - Rat Genome Database

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Myelin-associated glycoprotein demonstrated immunocytochemically in myelin and myelin-forming cells of developing rat.

Authors: Sternberger, NH  Quarles, RH  Itoyama, Y  Webster, HD 
Citation: Sternberger NH, etal., Proc Natl Acad Sci U S A. 1979 Mar;76(3):1510-4.
RGD ID: 9685298
Pubmed: PMID:375239   (View Abstract at PubMed)
PMCID: PMC383284   (View Article at PubMed Central)

The unlabeled peroxidase-antiperoxidase method has been used with antiserum against "myelin-associated glycoprotein" to establish the presence of the glycoprotein in myelin and myelin-forming cells of the developing rat nervous system. Myelin-associated glycoprotein is found in oligodendroglial cytoplasm before the beginning of myelination. Staining intensity of oligodendroglia increases during early development and slowly declines during the period of rapid myelination. Myelin staining is confined to the periaxonal region of the myelin sheath and does not increase as large, compact sheaths are formed. Antiserum to central nervous system myelin-associated glycoprotein also stains Schwann cells in developing trigeminal ganglia and the periaxonal region of peripheral myelin sheaths.



Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MagRatmyelin sheath adaxonal region  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mag  (myelin-associated glycoprotein)


Additional Information