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Gene: Fyn (FYN proto-oncogene, Src family tyrosine kinase) Rattus norvegicus
Symbol: Fyn
Name: FYN proto-oncogene, Src family tyrosine kinase
RGD ID: 2641
Description: Exhibits several functions, including phosphatidylinositol 3-kinase binding activity; protein tyrosine kinase activity; and signaling receptor binding activity. Involved in several processes, including cellular response to organonitrogen compound; negative regulation of cell death; and protein phosphorylation. Localizes to several cellular components, including mitochondrion; perinuclear endoplasmic reticulum; and postsynaptic density. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in Alzheimer's disease and schizophrenia. Orthologous to human FYN (FYN proto-oncogene, Src family tyrosine kinase); PARTICIPATES IN altered Reelin signaling pathway; E-cadherin signaling pathway; eicosanoid signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-arachidonoylglycerol; 4,4'-diaminodiphenylmethane.
Type: protein-coding
Also known as: FYN oncogene related to SRC, FGR, YES; fyn proto-oncogene; p59-Fyn; proto-oncogene c-Fyn; proto-oncogene tyrosine-protein kinase Fyn; tyrosine-protein kinase Fyn
Homo sapiens (human) : FYN (FYN proto-oncogene, Src family tyrosine kinase)  HGNC  Alliance
Mus musculus (house mouse) : Fyn (Fyn proto-oncogene)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fyn (FYN proto-oncogene, Src family tyrosine kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : FYN (FYN proto-oncogene, Src family tyrosine kinase)
Canis lupus familiaris (dog) : FYN (FYN proto-oncogene, Src family tyrosine kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fyn (FYN proto-oncogene, Src family tyrosine kinase)
Sus scrofa (pig) : FYN (FYN proto-oncogene, Src family tyrosine kinase)
Chlorocebus sabaeus (African green monkey) : FYN (FYN proto-oncogene, Src family tyrosine kinase)
Heterocephalus glaber (naked mole-rat) : Fyn (FYN proto-oncogene, Src family tyrosine kinase)
more info ...
Allele / Splice: Fynem6Mcwi   Fynem1Mcwi  
Genetic Models: SS-Fynem6Mcwi SS-Fynem1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02044,436,354 - 44,630,316 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2044,436,403 - 44,630,317 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02046,160,734 - 46,353,456 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42043,501,853 - 43,695,567 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12043,524,863 - 43,718,578 (+)NCBI
Celera2043,482,980 - 43,675,123 (+)NCBICelera
Cytogenetic Map20q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Fyn
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2641
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-09-29
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.