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Gene: Fyn (FYN proto-oncogene, Src family tyrosine kinase) Rattus norvegicus
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Symbol: Fyn
Name: FYN proto-oncogene, Src family tyrosine kinase
Description: Exhibits several functions, including enzyme binding activity; phosphatidylinositol 3-kinase binding activity; and signaling receptor binding activity. Involved in several processes, including cellular protein modification process; cellular response to organonitrogen compound; and negative regulation of cell death. Localizes to several cellular components, including the glutamatergic synapse; intracellular membrane-bounded organelle; and postsynaptic density, intracellular component. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in Alzheimer's disease and schizophrenia. Orthologous to human FYN (FYN proto-oncogene, Src family tyrosine kinase); PARTICIPATES IN altered Reelin signaling pathway; E-cadherin signaling pathway; eicosanoid signaling pathway; INTERACTS WITH (RS)-amphetamine; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: FYN oncogene related to SRC, FGR, YES; fyn proto-oncogene; p59-Fyn; proto-oncogene c-Fyn; proto-oncogene tyrosine-protein kinase Fyn; tyrosine-protein kinase Fyn
Orthologs:
Homo sapiens (human) : FYN (FYN proto-oncogene, Src family tyrosine kinase)  HGNC  Alliance
Mus musculus (house mouse) : Fyn (Fyn proto-oncogene)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fyn (FYN proto-oncogene, Src family tyrosine kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : FYN (FYN proto-oncogene, Src family tyrosine kinase)
Canis lupus familiaris (dog) : FYN (FYN proto-oncogene, Src family tyrosine kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fyn (FYN proto-oncogene, Src family tyrosine kinase)
Sus scrofa (pig) : FYN (FYN proto-oncogene, Src family tyrosine kinase)
more info ...
Allele / Splice: Fynem6Mcwi   Fynem1Mcwi  
Genetic Models: SS-Fynem6Mcwi SS-Fynem1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02044,436,354 - 44,630,316 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02046,160,734 - 46,353,456 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42043,501,853 - 43,695,567 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12043,524,863 - 43,718,578 (+)NCBI
Celera2043,482,980 - 43,675,123 (+)NCBICelera
Cytogenetic Map20q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Fyn
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2641
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.