Fyn (FYN proto-oncogene, Src family tyrosine kinase) - Rat Genome Database

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Gene: Fyn (FYN proto-oncogene, Src family tyrosine kinase) Rattus norvegicus
Analyze
Symbol: Fyn
Name: FYN proto-oncogene, Src family tyrosine kinase
RGD ID: 2641
Description: Enables several functions, including phosphatidylinositol 3-kinase binding activity; protein tyrosine kinase activity; and signaling receptor binding activity. Involved in several processes, including cellular response to organonitrogen compound; negative regulation of apoptotic process; and negative regulation of hydrogen peroxide biosynthetic process. Located in several cellular components, including mitochondrion; perinuclear endoplasmic reticulum; and postsynaptic density. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in Alzheimer's disease and schizophrenia. Orthologous to human FYN (FYN proto-oncogene, Src family tyrosine kinase); PARTICIPATES IN altered Reelin signaling pathway; E-cadherin signaling pathway; eicosanoid signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: FYN oncogene related to SRC, FGR, YES; fyn proto-oncogene; p59-Fyn; proto-oncogene c-Fyn; proto-oncogene tyrosine-protein kinase Fyn; tyrosine-protein kinase Fyn
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Fynem6Mcwi   Fynem1Mcwi  
Genetic Models: SS-Fynem6Mcwi SS-Fynem1Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22042,767,733 - 42,960,903 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2042,766,369 - 42,959,911 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2044,517,354 - 44,708,655 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02044,176,580 - 44,367,880 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02044,909,156 - 45,110,016 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02044,436,354 - 44,630,316 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2044,436,403 - 44,630,317 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02046,160,734 - 46,353,456 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42043,501,853 - 43,695,567 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12043,524,863 - 43,718,578 (+)NCBI
Celera2043,482,980 - 43,675,123 (+)NCBICelera
Cytogenetic Map20q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-nicotine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-arachidonoylglycerol  (EXP)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
alachlor  (EXP)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antigen  (ISO)
antimycin A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butanal  (ISO)
Butylparaben  (EXP)
caffeine  (ISO)
calcium dichloride  (ISO)
captan  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
D-gluconic acid  (EXP)
DDE  (EXP)
deguelin  (ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
diazinon  (EXP,ISO)
dibutyl phthalate  (EXP)
dieldrin  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzacamene  (EXP)
epoxiconazole  (EXP)
ethanol  (ISO)
etoposide  (ISO)
folpet  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
glutathione  (ISO)
haloperidol  (ISO)
inulin  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP)
linuron  (EXP)
lithium chloride  (EXP)
LY294002  (ISO)
methamphetamine  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methylmercury chloride  (EXP)
methylparaben  (ISO)
methylseleninic acid  (ISO)
mitomycin C  (ISO)
mitoxantrone  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-D-aspartic acid  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
O-methyleugenol  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylarsine oxide  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
ponatinib  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
propanal  (ISO)
puerarin  (EXP,ISO)
resveratrol  (ISO)
rotenone  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
Soman  (EXP)
succimer  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tebufenpyrad  (ISO)
testosterone  (EXP)
titanium dioxide  (ISO)
tolonium chloride  (ISO)
topotecan  (EXP)
tremolite asbestos  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
Triptolide  (EXP)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activated T cell proliferation  (IEA,ISO)
canonical NF-kappaB signal transduction  (IEA,ISO)
cell differentiation  (IBA)
cell surface receptor signaling pathway  (ISO)
cellular response to amyloid-beta  (IEA,ISO)
cellular response to glycine  (IMP)
cellular response to growth factor stimulus  (IEP)
cellular response to hydrogen peroxide  (IDA)
cellular response to L-glutamate  (IMP)
cellular response to peptide hormone stimulus  (IEP)
cellular response to platelet-derived growth factor stimulus  (IEA,ISO)
cellular response to transforming growth factor beta stimulus  (IEA,ISO)
dendrite morphogenesis  (IEA,ISO)
detection of mechanical stimulus involved in sensory perception of pain  (IEA,ISO)
forebrain development  (IEA,ISO)
heart process  (IEA,ISO)
innate immune response  (IBA)
intracellular signal transduction  (ISO)
ionotropic glutamate receptor signaling pathway  (TAS)
modulation of chemical synaptic transmission  (IEA,ISO)
negative regulation of dendritic spine maintenance  (IEA,ISO)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (IMP)
negative regulation of gene expression  (IEA,ISO)
negative regulation of hydrogen peroxide biosynthetic process  (IMP)
negative regulation of neuron apoptotic process  (IMP)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (IMP)
negative regulation of protein catabolic process  (IEA,ISO)
negative regulation of protein ubiquitination  (IEA,ISO)
neuron migration  (IEA,ISO)
neuron projection development  (ISO)
peptidyl-tyrosine phosphorylation  (IDA,IMP)
phosphorylation  (IEA)
positive regulation of canonical NF-kappaB signal transduction  (IEA,ISO)
positive regulation of neuron projection development  (IEA,ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IMP)
positive regulation of protein localization to nucleus  (IEA,ISO)
positive regulation of protein targeting to membrane  (IEA,ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (IEA,ISO)
protein autophosphorylation  (IDA)
protein catabolic process  (IEA,ISO)
protein ubiquitination  (IEA,ISO)
regulation of calcium ion import across plasma membrane  (IEA,ISO)
regulation of cell shape  (IEA,ISO)
regulation of glutamate receptor signaling pathway  (IEA,ISO)
regulation of peptidyl-tyrosine phosphorylation  (ISO)
response to amyloid-beta  (ISO)
response to ethanol  (IEA,ISO)
response to singlet oxygen  (IDA)
response to xenobiotic stimulus  (IEP)
T cell receptor signaling pathway  (IBA,IEA,ISO)
transmembrane receptor protein tyrosine kinase signaling pathway  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Prolactin induced tyrosine phosphorylation of p59fyn may mediate phosphatidylinositol 3-kinase activation in Nb2 cells. al-Sakkaf KA, etal., J Mol Endocrinol. 1997 Dec;19(3):347-50.
2. Association of Src-like protein tyrosine kinases with the CD2 cell surface molecule in rat T lymphocytes and natural killer cells. Bell GM, etal., Mol Cell Biol. 1992 Dec;12(12):5548-54.
3. Molecular associations between the T-lymphocyte antigen receptor complex and the surface antigens CD2, CD4, or CD8 and CD5. Beyers AD, etal., Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):2945-9.
4. Phosphatidylinositol 3-kinase interacts with the adaptor protein Dab1 in response to Reelin signaling and is required for normal cortical lamination. Bock HH, etal., J Biol Chem 2003 Oct 3;278(40):38772-9. Epub 2003 Jul 25.
5. Physical association of the cytoplasmic domain of CD2 with the tyrosine kinases p56lck and p59fyn. Carmo AM, etal., Eur J Immunol. 1993 Sep;23(9):2196-201.
6. Tyrosine kinase and tyrosine phosphatase participate in regulation of interactions of NMDA receptor subunit 2A with Src and Fyn mediated by PSD-95 after transient brain ischemia. Chen M, etal., Neurosci Lett. 2003 Mar 13;339(1):29-32.
7. Activation of RBL-2H3 mast cells is dependent on tyrosine phosphorylation of phospholipase D2 by Fyn and Fgr. Choi WS, etal., Mol Cell Biol 2004 Aug;24(16):6980-92.
8. Prostaglandin E2 modulation of p59fyn tyrosine kinase in T lymphocytes during sepsis. Choudhry MA, etal., J Immunol. 1998 Jan 15;160(2):929-35.
9. TGF-beta abrogates TCR-mediated signaling by upregulating tyrosine phosphatases in T cells. Choudhry MA, etal., Shock. 2001 Mar;15(3):193-9.
10. Role of NFAT and AP-1 in PGE2-mediated T cell suppression in burn injury. Choudhry MA, etal., Shock. 2002 Sep;18(3):212-6.
11. Identification of a novel protein complex containing annexin VI, Fyn, Pyk2, and the p120(GAP) C2 domain. Chow A, etal., FEBS Lett. 2000 Mar 3;469(1):88-92.
12. The protein tyrosine kinase P59fyn is associated with prolactin (PRL) receptor and is activated by PRL stimulation of T-lymphocytes. Clevenger CV and Medaglia MV, Mol Endocrinol. 1994 Jun;8(6):674-81.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
15. Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice. Grant SG, etal., Science 1992 Dec 18;258(5090):1903-10.
16. Altered p59Fyn kinase expression accompanies disease progression in Alzheimer's disease: implications for its functional role. Ho GJ, etal., Neurobiol Aging 2005 May;26(5):625-35.
17. Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition. Holmes K, etal., Cell Signal. 2007 Oct;19(10):2003-12. Epub 2007 Jun 12.
18. Activation of NMDA receptors and L-type voltage-gated calcium channels mediates enhanced formation of Fyn-PSD95-NR2A complex after transient brain ischemia. Hou XY, etal., Brain Res 2002 Nov 15;955(1-2):123-32.
19. Effects of pentoxyfylline on mesenteric lymph node T-cells in a rat model of thermal injury. Kotadia BK, etal., Shock. 2003 Dec;20(6):517-20.
20. Phosphorylation of tau by fyn: implications for Alzheimer's disease. Lee G, etal., J Neurosci 2004 Mar 3;24(9):2304-12.
21. Tyrosine kinase FYN negatively regulates NOX4 in cardiac remodeling. Matsushima S, etal., J Clin Invest. 2016 Sep 1;126(9):3403-16. doi: 10.1172/JCI85624. Epub 2016 Aug 15.
22. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
23. Thy-1 molecule associates with protein tyrosine kinase(s) in rat mesangial cells. Narisawa-Saito M, etal., Clin Exp Immunol. 1996 Oct;106(1):86-90.
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. Phosphorylation of c-Cbl protooncogene product following ethanol administration in rat cerebellum: possible involvement of Fyn kinase. Nishio H, etal., Brain Res 2002 Sep 20;950(1-2):203-9.
26. Expression of Fyn, a non-receptor tyrosine kinase in prefrontal cortex from patients with schizophrenia and its correlation with clinical onset. Ohnuma T, etal., Brain Res Mol Brain Res 2003 Apr 10;112(1-2):90-4.
27. CSK: a protein-tyrosine kinase involved in regulation of src family kinases. Okada M, etal., J Biol Chem. 1991 Dec 25;266(36):24249-52.
28. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
29. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
30. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
31. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
32. PKC-interacting proteins: from function to pharmacology. Poole AW, etal., Trends Pharmacol Sci. 2004 Oct;25(10):528-35.
33. GOA pipeline RGD automated data pipeline
34. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. Characterization and location of Src-dependent tyrosine phosphorylation in rat brain mitochondria. Salvi M, etal., Biochim Biophys Acta 2002 Apr 3;1589(2):181-95.
37. Opioid addiction and pregnancy: perinatal exposure to buprenorphine affects myelination in the developing brain. Sanchez ES, etal., Glia. 2008 Jul;56(9):1017-27. doi: 10.1002/glia.20675.
38. Caveolin-1 facilitates mechanosensitive protein kinase B (Akt) signaling in vitro and in vivo. Sedding DG, etal., Circ Res. 2005 Apr 1;96(6):635-42. Epub 2005 Feb 24.
39. A unique role for Fyn in CNS myelination. Sperber BR, etal., J Neurosci 2001 Mar 15;21(6):2039-47.
40. Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B. Tang X, etal., Nat Cell Biol. 2008 Jun;10(6):698-706. doi: 10.1038/ncb1732. Epub 2008 May 11.
41. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
42. Reelin and brain development. Tissir F and Goffinet AM, Nat Rev Neurosci. 2003 Jun;4(6):496-505.
43. Alzheimer amyloid-ß oligomer bound to postsynaptic prion protein activates Fyn to impair neurons. Um JW, etal., Nat Neurosci. 2012 Sep;15(9):1227-35. doi: 10.1038/nn.3178. Epub 2012 Jul 22.
44. Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer abeta oligomer bound to cellular prion protein. Um JW, etal., Neuron. 2013 Sep 4;79(5):887-902. doi: 10.1016/j.neuron.2013.06.036.
45. PSD-95 stabilizes NMDA receptors by inducing the degradation of STEP61. Won S, etal., Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):E4736-44. doi: 10.1073/pnas.1609702113. Epub 2016 Jul 25.
46. Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems. Wu HY, etal., J Biol Chem. 2007 Jul 13;282(28):20075-87. doi: 10.1074/jbc.M700624200. Epub 2007 May 25.
47. Kainate-induced seizures alter protein composition and N-methyl-D-aspartate receptor function of rat forebrain postsynaptic densities. Wyneken U, etal., Neuroscience. 2001;102(1):65-74.
48. A role for Fyn tyrosine kinase in the suckling behaviour of neonatal mice. Yagi T, etal., Nature 1993 Dec 23-30;366(6457):742-5.
49. Pituitary adenylate cyclase-activating polypeptide (PACAP(1-38)) enhances N-methyl-D-aspartate receptor function and brain-derived neurotrophic factor expression via RACK1. Yaka R, etal., J Biol Chem 2003 Mar 14;278(11):9630-8.
50. Scaffolding of Fyn kinase to the NMDA receptor determines brain region sensitivity to ethanol. Yaka R, etal., J Neurosci 2003 May 1;23(9):3623-32.
51. NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1. Yaka R, etal., Proc Natl Acad Sci U S A 2002 Apr 16;99(8):5710-5. Epub 2002 Apr 9.
Additional References at PubMed
PMID:1381360   PMID:1516132   PMID:2062320   PMID:7722293   PMID:8175795   PMID:8196616   PMID:8402898   PMID:8761480   PMID:9177270   PMID:9351809   PMID:9381182   PMID:9799234  
PMID:9892651   PMID:10366594   PMID:10498895   PMID:10861086   PMID:10872802   PMID:11110698   PMID:11181827   PMID:11448999   PMID:11826099   PMID:12150984   PMID:12372285   PMID:12538589  
PMID:12681493   PMID:12923167   PMID:14531861   PMID:14697322   PMID:14741357   PMID:14993658   PMID:15073522   PMID:15579503   PMID:15611048   PMID:16162939   PMID:16190898   PMID:16479011  
PMID:16709819   PMID:16841086   PMID:16860569   PMID:16921024   PMID:16979591   PMID:17462920   PMID:17623777   PMID:17923684   PMID:18089558   PMID:18354028   PMID:18682436   PMID:18697750  
PMID:18701695   PMID:18922801   PMID:19109931   PMID:19115405   PMID:19166962   PMID:19178193   PMID:19441121   PMID:19625508   PMID:19652227   PMID:19816407   PMID:19888448   PMID:20142099  
PMID:20569495   PMID:20655099   PMID:20978343   PMID:21829547   PMID:22057277   PMID:22433866   PMID:22437915   PMID:22802969   PMID:22833681   PMID:23169819   PMID:23386614   PMID:23438599  
PMID:23962429   PMID:24003228   PMID:24173619   PMID:24627473   PMID:24675471   PMID:25106729   PMID:25156556   PMID:25289695   PMID:25340851   PMID:25565773   PMID:26277342   PMID:26449489  
PMID:26777117   PMID:26901312   PMID:27001024   PMID:27520374   PMID:27692963   PMID:27926876   PMID:28497343   PMID:28948209   PMID:30129387   PMID:31840160   PMID:31852295   PMID:32145272  
PMID:32929078   PMID:33409551  


Genomics

Comparative Map Data
Fyn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22042,767,733 - 42,960,903 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2042,766,369 - 42,959,911 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2044,517,354 - 44,708,655 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02044,176,580 - 44,367,880 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02044,909,156 - 45,110,016 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02044,436,354 - 44,630,316 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2044,436,403 - 44,630,317 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02046,160,734 - 46,353,456 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42043,501,853 - 43,695,567 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12043,524,863 - 43,718,578 (+)NCBI
Celera2043,482,980 - 43,675,123 (+)NCBICelera
Cytogenetic Map20q12NCBI
FYN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386111,660,332 - 111,873,452 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6111,660,332 - 111,873,452 (-)EnsemblGRCh38hg38GRCh38
GRCh376111,981,535 - 112,194,655 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366112,089,178 - 112,301,320 (-)NCBINCBI36Build 36hg18NCBI36
Build 346112,089,179 - 112,186,978NCBI
Celera6112,729,071 - 112,941,209 (-)NCBICelera
Cytogenetic Map6q21NCBI
HuRef6109,554,123 - 109,767,060 (-)NCBIHuRef
CHM1_16112,244,349 - 112,457,405 (-)NCBICHM1_1
T2T-CHM13v2.06112,843,350 - 113,056,537 (-)NCBIT2T-CHM13v2.0
Fyn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391039,245,735 - 39,441,377 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1039,244,851 - 39,441,377 (+)EnsemblGRCm39 Ensembl
GRCm381039,369,743 - 39,565,381 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1039,368,855 - 39,565,381 (+)EnsemblGRCm38mm10GRCm38
MGSCv371039,089,605 - 39,285,187 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361039,059,502 - 39,254,797 (+)NCBIMGSCv36mm8
Celera1040,254,667 - 40,450,960 (+)NCBICelera
Cytogenetic Map10B1NCBI
cM Map1020.51NCBI
Fyn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541136,401,842 - 36,512,054 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541136,403,156 - 36,597,660 (-)NCBIChiLan1.0ChiLan1.0
FYN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan16129,561,361 - 129,775,652 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06109,469,750 - 109,684,086 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16113,545,944 - 113,732,893 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6113,545,944 - 113,604,451 (-)Ensemblpanpan1.1panPan2
FYN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11268,105,060 - 68,316,630 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1268,075,184 - 68,316,541 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1267,924,675 - 68,136,151 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01268,986,784 - 69,198,525 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1268,987,778 - 69,174,188 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11268,338,226 - 68,549,311 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01268,184,783 - 68,396,306 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01268,510,644 - 68,722,405 (-)NCBIUU_Cfam_GSD_1.0
Fyn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946103,155,533 - 103,356,140 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936679387,387 - 443,880 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936679388,500 - 588,518 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FYN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl177,585,439 - 77,810,581 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1177,584,675 - 77,810,605 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2187,249,062 - 87,253,260 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2187,146,809 - 87,191,215 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1p13NCBI
FYN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11361,988,265 - 62,218,756 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1362,159,874 - 62,219,672 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604034,319,593 - 34,528,593 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fyn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624933389,627 - 456,520 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624933248,298 - 456,933 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fyn
1223 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:98
Count of miRNA genes:81
Interacting mature miRNAs:87
Transcripts:ENSRNOT00000000733
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202510672254435887Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202510672254435887Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202510672254435887Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202520973454435887Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202924438854435887Rat
70158Bp60Blood pressure QTL 603arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)203161428444396023Rat

Markers in Region
D20Rat55  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22042,886,819 - 42,887,012 (+)MAPPERmRatBN7.2
Rnor_6.02044,555,562 - 44,555,754NCBIRnor6.0
Rnor_5.02046,279,994 - 46,280,186UniSTSRnor5.0
RGSC_v3.42043,622,153 - 43,622,346RGDRGSC3.4
RGSC_v3.42043,622,154 - 43,622,346UniSTSRGSC3.4
RGSC_v3.12043,645,165 - 43,645,357RGD
Celera2043,601,937 - 43,602,129UniSTS
RH 3.4 Map20456.5RGD
RH 3.4 Map20456.5UniSTS
RH 2.0 Map20505.7RGD
SHRSP x BN Map2034.4RGD
Cytogenetic Map20q13UniSTS
RH137616  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22042,953,267 - 42,953,470 (+)MAPPERmRatBN7.2
Rnor_6.02044,622,917 - 44,623,119NCBIRnor6.0
Rnor_5.02046,346,156 - 46,346,358UniSTSRnor5.0
RGSC_v3.42043,690,007 - 43,690,209UniSTSRGSC3.4
Celera2043,668,270 - 43,668,472UniSTS
Cytogenetic Map20q13UniSTS
BE113818  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22042,929,193 - 42,929,354 (+)MAPPERmRatBN7.2
Rnor_6.02044,599,140 - 44,599,300NCBIRnor6.0
Rnor_5.02046,322,955 - 46,323,115UniSTSRnor5.0
RGSC_v3.42043,665,213 - 43,665,373UniSTSRGSC3.4
RH 3.4 Map20464.21UniSTS
Cytogenetic Map20q13UniSTS
BF405827  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22042,813,674 - 42,813,840 (+)MAPPERmRatBN7.2
Rnor_6.02044,482,223 - 44,482,388NCBIRnor6.0
Rnor_5.02046,206,603 - 46,206,768UniSTSRnor5.0
RGSC_v3.42043,547,466 - 43,547,631UniSTSRGSC3.4
Celera2043,528,623 - 43,528,788UniSTS
RH 3.4 Map20452.8UniSTS
Cytogenetic Map20q13UniSTS
FYN_1578  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22042,959,298 - 42,959,937 (+)MAPPERmRatBN7.2
Rnor_6.02044,628,711 - 44,629,349NCBIRnor6.0
Rnor_5.02046,351,851 - 46,352,489UniSTSRnor5.0
RGSC_v3.42043,695,391 - 43,696,029UniSTSRGSC3.4
Celera2043,674,947 - 43,675,585UniSTS
Cytogenetic Map20q13UniSTS


Genetic Models
This gene Fyn is modified in the following models/strains

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 43 22 6 19 6 1 1 74 25 41 11 1
Low 1 35 35 35 7 10 10 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000000733   ⟹   ENSRNOP00000000733
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2042,792,180 - 42,959,911 (+)Ensembl
Rnor_6.0 Ensembl2044,436,403 - 44,630,317 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000075922   ⟹   ENSRNOP00000068462
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2042,910,988 - 42,959,475 (+)Ensembl
Rnor_6.0 Ensembl2044,580,632 - 44,596,045 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076859   ⟹   ENSRNOP00000068458
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2042,792,180 - 42,959,833 (+)Ensembl
Rnor_6.0 Ensembl2044,436,408 - 44,629,323 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000085987   ⟹   ENSRNOP00000072210
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2042,792,180 - 42,959,911 (+)Ensembl
Rnor_6.0 Ensembl2044,521,279 - 44,630,294 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000118910   ⟹   ENSRNOP00000088889
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2042,766,369 - 42,959,911 (+)Ensembl
RefSeq Acc Id: NM_012755   ⟹   NP_036887
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22042,768,059 - 42,959,475 (+)NCBI
Rnor_6.02044,436,680 - 44,628,887 (+)NCBI
Rnor_5.02046,160,734 - 46,353,456 (+)NCBI
RGSC_v3.42043,501,853 - 43,695,567 (+)RGD
Celera2043,482,980 - 43,675,123 (+)RGD
Sequence:
RefSeq Acc Id: XM_006256522   ⟹   XP_006256584
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22042,767,733 - 42,960,903 (+)NCBI
Rnor_6.02044,436,354 - 44,630,316 (+)NCBI
Rnor_5.02046,160,734 - 46,353,456 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017601549   ⟹   XP_017457038
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22042,767,733 - 42,960,903 (+)NCBI
Rnor_6.02044,577,312 - 44,630,316 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039098436   ⟹   XP_038954364
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22042,767,733 - 42,960,903 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_036887   ⟸   NM_012755
- UniProtKB: Q62844 (UniProtKB/Swiss-Prot),   A0A096MKC1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256584   ⟸   XM_006256522
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A612 (UniProtKB/TrEMBL),   A0A096MKC1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457038   ⟸   XM_017601549
- Peptide Label: isoform X2
- UniProtKB: A0A096MKC1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000000733   ⟸   ENSRNOT00000000733
RefSeq Acc Id: ENSRNOP00000068462   ⟸   ENSRNOT00000075922
RefSeq Acc Id: ENSRNOP00000072210   ⟸   ENSRNOT00000085987
RefSeq Acc Id: ENSRNOP00000068458   ⟸   ENSRNOT00000076859
RefSeq Acc Id: XP_038954364   ⟸   XM_039098436
- Peptide Label: isoform X3
- UniProtKB: Q62844 (UniProtKB/Swiss-Prot),   A0A096MKC1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000088889   ⟸   ENSRNOT00000118910
Protein Domains
Protein kinase   SH2   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62844-F1-model_v2 AlphaFold Q62844 1-537 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2641 AgrOrtholog
BioCyc Gene G2FUF-3474 BioCyc
Ensembl Genes ENSRNOG00000000596 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000000733 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000068458 ENTREZGENE
  ENSRNOP00000068458.1 UniProtKB/TrEMBL
  ENSRNOP00000068462.2 UniProtKB/TrEMBL
  ENSRNOP00000072210.1 UniProtKB/TrEMBL
  ENSRNOP00000088889 ENTREZGENE
  ENSRNOP00000088889.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000733 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000075922.2 UniProtKB/TrEMBL
  ENSRNOT00000076859 ENTREZGENE
  ENSRNOT00000076859.3 UniProtKB/TrEMBL
  ENSRNOT00000085987.2 UniProtKB/TrEMBL
  ENSRNOT00000118910 ENTREZGENE
  ENSRNOT00000118910.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 Domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Fyn/Yrk_SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Grb2-like UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25150 UniProtKB/Swiss-Prot
NCBI Gene 25150 ENTREZGENE
PANTHER PROTEIN ENHANCER OF SEVENLESS 2B UniProtKB/TrEMBL
  SRC-LIKE-ADAPTER UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE FYN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE FYN UniProtKB/TrEMBL
Pfam Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fyn PhenoGen
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC207354
UniProt A0A096MKC1 ENTREZGENE, UniProtKB/TrEMBL
  A0A096MKC5_RAT UniProtKB/TrEMBL
  A0A0G2K2E3_RAT UniProtKB/TrEMBL
  A0A8I6A612 ENTREZGENE, UniProtKB/TrEMBL
  A6KIG1_RAT UniProtKB/TrEMBL
  A6KIG4_RAT UniProtKB/TrEMBL
  FYN_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-18 Fyn  FYN oncogene related to SRC, FGR, YES  Fyn  fyn proto-oncogene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Fyn  Fyn proto-oncogene      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction coexpressed with and binds to Cbl protein in the cerebellum 632732