Rack1 (receptor for activated C kinase 1) - Rat Genome Database

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Gene: Rack1 (receptor for activated C kinase 1) Rattus norvegicus
Analyze
Symbol: Rack1
Name: receptor for activated C kinase 1
RGD ID: 69229
Description: Enables protein kinase C binding activity. Involved in negative regulation of translation and regulation of protein localization to plasma membrane. Located in membrane. Part of small ribosomal subunit. Used to study transient cerebral ischemia. Orthologous to human RACK1 (receptor for activated C kinase 1); PARTICIPATES IN hypoxia inducible factor pathway; insulin-like growth factor signaling pathway; protein kinase C (PKC) signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Gnb2l1; guanine nucleotide binding protein (G protein) beta polypeptide 2-like 1; guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1; guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1; guanine nucleotide binding protein, beta polypeptide 2-like 1; guanine nucleotide-binding protein subunit beta-2-like 1; protein kinase C receptor; receptor for activated C kinase; receptor for activated protein kinase C; receptor of activated protein C kinase 1; receptor of activated protein kinase C 1; small ribosomal subunit protein RACK1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81033,668,560 - 33,676,031 (+)NCBIGRCr8
mRatBN7.21033,169,415 - 33,174,896 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1033,169,169 - 33,174,975 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1037,849,601 - 37,855,081 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0106,388,024 - 6,393,504 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01032,843,239 - 32,848,719 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01034,149,717 - 34,155,198 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1034,149,717 - 34,155,198 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1235,905,358 - 35,906,382 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01033,920,259 - 33,939,101 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41034,067,237 - 34,072,593 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11034,068,286 - 34,073,642 (+)NCBI
Celera1032,555,573 - 32,561,054 (+)NCBICelera
Cytogenetic Map10q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
alpha-naphthoflavone  (EXP)
ammonium chloride  (EXP)
androst-4-ene-3,17-dione  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
azithromycin  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
butan-1-ol  (ISO)
cadmium atom  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cumene  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
DDT  (ISO)
dehydroepiandrosterone  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diazinon  (ISO)
diclofenac  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
ferric ammonium citrate  (ISO)
flutamide  (EXP,ISO)
FR900359  (ISO)
furan  (EXP)
glafenine  (EXP)
glyphosate  (ISO)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP)
indometacin  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
menadione  (ISO)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nandrolone  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
propiconazole  (ISO)
prostaglandin A1  (ISO)
quercetin  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (EXP)
Salinomycin  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
tungsten  (ISO)
valproic acid  (EXP,ISO)
vincristine  (ISO)
zearalenone  (ISO)
zinc sulfate  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
apoptotic process  (IEA)
cellular response to glucose stimulus  (ISO)
cellular response to growth factor stimulus  (ISO,ISS)
gastrulation  (IEA)
negative regulation of cell growth  (ISO,ISS)
negative regulation of gene expression  (ISO)
negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide  (IEA,ISO)
negative regulation of peptidyl-serine phosphorylation  (ISO)
negative regulation of phagocytosis  (ISO,ISS)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
negative regulation of smoothened signaling pathway  (ISO)
negative regulation of translation  (IMP)
negative regulation of Wnt signaling pathway  (ISS)
osteoblast differentiation  (HDA)
phospholipase C-activating G protein-coupled receptor signaling pathway  (TAS)
pigmentation  (IEA,ISO)
positive regulation of apoptotic process  (ISO,ISS)
positive regulation of cell migration  (ISO,ISS)
positive regulation of gastrulation  (ISS)
positive regulation of Golgi to plasma membrane protein transport  (ISO,ISS)
positive regulation of GTPase activity  (ISO,ISS)
positive regulation of intrinsic apoptotic signaling pathway  (ISO)
positive regulation of mitochondrial depolarization  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (ISO,ISS)
positive regulation of protein phosphorylation  (ISO,ISS)
positive regulation of protein-containing complex assembly  (ISO,ISS)
protein ubiquitination  (ISO,ISS)
regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
regulation of cell cycle  (ISO,ISS)
regulation of cell division  (ISS)
regulation of establishment of cell polarity  (ISS)
regulation of protein localization  (ISS)
regulation of protein localization to plasma membrane  (IMP)
regulation of translation  (IEA)
rescue of stalled ribosome  (IBA,ISO,ISS)
rhythmic process  (IEA)
translation  (IEA,ISO)

Cellular Component
cell body  (ISO)
cytoplasm  (IEA,ISO,ISS)
cytosol  (IBA,ISO)
dendrite  (IEA,ISO)
IRE1-RACK1-PP2A complex  (ISO)
membrane  (HDA)
midbody  (ISO,ISS)
mitochondrion  (ISO)
neuron projection  (ISO)
neuronal cell body  (IEA,ISO,ISS)
nucleoplasm  (ISO)
nucleus  (IBA,ISO,ISS)
perikaryon  (IEA)
perinuclear region of cytoplasm  (ISO,ISS)
phagocytic cup  (ISO,ISS)
plasma membrane  (IEA)
small ribosomal subunit  (IDA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Differential expression profiling of membrane proteins by quantitative proteomics in a human mesenchymal stem cell line undergoing osteoblast differentiation. Foster LJ, etal., Stem Cells. 2005 Oct;23(9):1367-77.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Yeast Asc1p and mammalian RACK1 are functionally orthologous core 40S ribosomal proteins that repress gene expression. Gerbasi VR, etal., Mol Cell Biol. 2004 Sep;24(18):8276-87.
4. Early activation of nSMase2/ceramide pathway in astrocytes is involved in ischemia-associated neuronal damage via inflammation in rat hippocampi. Gu L, etal., J Neuroinflammation. 2013 Sep 3;10:109. doi: 10.1186/1742-2094-10-109.
5. Translocation of PKC-betaII is mediated via RACK-1 in the neuronal cells following dioxin exposure. Lee HG, etal., Neurotoxicology. 2007 Mar;28(2):408-14. Epub 2006 May 5.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Eukaryotic initiation factor 6 mediates a continuum between 60S ribosome biogenesis and translation. Miluzio A, etal., EMBO Rep. 2009 May;10(5):459-65. doi: 10.1038/embor.2009.70. Epub 2009 Apr 17.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins. Ron D, etal., Proc Natl Acad Sci U S A 1994 Feb 1;91(3):839-43.
14. Regulation of oxygen homeostasis by hypoxia-inducible factor 1. Semenza GL Physiology (Bethesda). 2009 Apr;24:97-106.
15. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
16. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
17. Protein scaffolds, lipid domains and substrate recognition in protein kinase C function: implications for rational drug design. Walker JW Handb Exp Pharmacol. 2008;(186):185-203.
18. Protein receptor for activated C kinase 1 is involved in morphine reward in mice. Wan L, etal., Neuroscience. 2009 Jul 7;161(3):734-42. doi: 10.1016/j.neuroscience.2009.03.064. Epub 2009 Mar 31.
19. Pituitary adenylate cyclase-activating polypeptide (PACAP(1-38)) enhances N-methyl-D-aspartate receptor function and brain-derived neurotrophic factor expression via RACK1. Yaka R, etal., J Biol Chem 2003 Mar 14;278(11):9630-8.
20. NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1. Yaka R, etal., Proc Natl Acad Sci U S A 2002 Apr 16;99(8):5710-5. Epub 2002 Apr 9.
21. SLC9A9 mutations, gene expression, and protein-protein interactions in rat models of attention-deficit/hyperactivity disorder. Zhang-James Y, etal., Am J Med Genet B Neuropsychiatr Genet. 2011 Dec;156B(7):835-43. doi: 10.1002/ajmg.b.31229. Epub 2011 Aug 19.
Additional References at PubMed
PMID:9584165   PMID:10849009   PMID:11278757   PMID:11279199   PMID:11312657   PMID:11884618   PMID:12826667   PMID:14983009   PMID:15042584   PMID:15140893   PMID:15159402   PMID:15166316  
PMID:15202772   PMID:15489334   PMID:15632090   PMID:16414032   PMID:17108144   PMID:17166942   PMID:17515463   PMID:17900863   PMID:17908799   PMID:18258429   PMID:18504258   PMID:19056867  
PMID:19198660   PMID:19451233   PMID:19674157   PMID:19767770   PMID:19785988   PMID:20010870   PMID:20103773   PMID:20410295   PMID:20499158   PMID:20541605   PMID:20819076   PMID:21347310  
PMID:21844488   PMID:22069327   PMID:22082260   PMID:22658674   PMID:22681889   PMID:22871113   PMID:23212600   PMID:23297403   PMID:23303411   PMID:23376485   PMID:23836701   PMID:24056044  
PMID:24625528   PMID:24947010   PMID:25468996   PMID:26659395   PMID:26711306   PMID:27212270   PMID:28100502   PMID:28132843   PMID:28472300   PMID:29476059   PMID:29511370   PMID:29518365  
PMID:31491465   PMID:32157145   PMID:37820423   PMID:38523594   PMID:38532543   PMID:39097918  


Genomics

Comparative Map Data
Rack1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81033,668,560 - 33,676,031 (+)NCBIGRCr8
mRatBN7.21033,169,415 - 33,174,896 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1033,169,169 - 33,174,975 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1037,849,601 - 37,855,081 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0106,388,024 - 6,393,504 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01032,843,239 - 32,848,719 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01034,149,717 - 34,155,198 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1034,149,717 - 34,155,198 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1235,905,358 - 35,906,382 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01033,920,259 - 33,939,101 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41034,067,237 - 34,072,593 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11034,068,286 - 34,073,642 (+)NCBI
Celera1032,555,573 - 32,561,054 (+)NCBICelera
Cytogenetic Map10q21NCBI
RACK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385181,236,897 - 181,243,906 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5181,236,897 - 181,248,096 (-)EnsemblGRCh38hg38GRCh38
GRCh375180,663,897 - 180,670,906 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365180,596,534 - 180,603,512 (-)NCBINCBI36Build 36hg18NCBI36
Build 345180,596,556 - 180,603,502NCBI
Celera5176,291,782 - 176,298,759 (-)NCBICelera
Cytogenetic Map5q35.3NCBI
HuRef5175,390,873 - 175,397,848 (-)NCBIHuRef
CHM1_15180,096,332 - 180,103,310 (-)NCBICHM1_1
T2T-CHM13v2.05181,796,848 - 181,803,858 (-)NCBIT2T-CHM13v2.0
Rack1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391148,691,187 - 48,697,068 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1148,691,159 - 48,697,261 (+)EnsemblGRCm39 Ensembl
GRCm381148,800,360 - 48,806,241 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1148,800,332 - 48,806,434 (+)EnsemblGRCm38mm10GRCm38
MGSCv371148,613,862 - 48,619,743 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361148,643,783 - 48,649,664 (+)NCBIMGSCv36mm8
Celera1153,382,599 - 53,388,480 (+)NCBICelera
Cytogenetic Map11B1.2NCBI
cM Map1128.77NCBI
Rack1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495553078,426 - 83,297 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495553078,488 - 83,297 (+)NCBIChiLan1.0ChiLan1.0
RACK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24176,260,574 - 176,276,707 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15174,424,640 - 174,434,127 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05176,462,991 - 176,470,153 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15183,712,665 - 183,720,128 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5183,712,665 - 183,720,128 (-)Ensemblpanpan1.1panPan2
RACK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.111426,734 - 431,087 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl11426,215 - 431,089 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha11485,398 - 489,759 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.011388,903 - 393,264 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl11388,384 - 393,273 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.111361,070 - 365,431 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.011448,653 - 453,014 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.011610,070 - 614,431 (-)NCBIUU_Cfam_GSD_1.0
Rack1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213117,852,090 - 117,857,037 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936826747,291 - 753,442 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936826748,256 - 753,460 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RACK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl257,279,857 - 57,284,849 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1257,280,192 - 57,284,846 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
RACK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12382,800,211 - 82,805,769 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2382,798,085 - 82,805,936 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607514,238,895 - 14,245,606 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rack1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624958181,273 - 185,620 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624958181,325 - 185,620 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rack1
8 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)102795762634490668Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
631531Iresp2Immunoglobin response QTL26.3blood immunoglobulin E amount (VT:0002492)serum immunoglobulin E level (CMO:0002101)102291826836400810Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat

Markers in Region
RH127943  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215106,667 - 106,887 (+)MAPPERmRatBN7.2
mRatBN7.21033,173,170 - 33,174,731 (+)MAPPERmRatBN7.2
Rnor_6.01034,153,473 - 34,155,033NCBIRnor6.0
Rnor_6.015148,807 - 149,026NCBIRnor6.0
Rnor_5.015144,153 - 144,372UniSTSRnor5.0
Rnor_5.01033,937,376 - 33,938,936UniSTSRnor5.0
RGSC_v3.41034,070,951 - 34,072,511UniSTSRGSC3.4
RGSC_v3.415104,836 - 105,055UniSTSRGSC3.4
Celera154,440,546 - 4,440,765UniSTS
Celera1032,559,329 - 32,560,889UniSTS
Cytogenetic Map10q21UniSTS
Cytogenetic Map15p16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
16 15 57 144 133 132 78 44 78 12 301 141 109 56 80 54

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_130734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC109931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC063809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U03390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000072179   ⟹   ENSRNOP00000068758
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1235,905,358 - 35,906,382 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000084232   ⟹   ENSRNOP00000074147
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1033,169,407 - 33,174,975 (+)Ensembl
Rnor_6.0 Ensembl1034,149,717 - 34,155,198 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000089829   ⟹   ENSRNOP00000071017
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1033,169,169 - 33,174,832 (+)Ensembl
Rnor_6.0 Ensembl1034,149,752 - 34,154,738 (+)Ensembl
RefSeq Acc Id: NM_130734   ⟹   NP_570090
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81033,670,550 - 33,676,031 (+)NCBI
mRatBN7.21033,169,415 - 33,174,896 (+)NCBI
Rnor_6.01034,149,717 - 34,155,198 (+)NCBI
Rnor_5.01033,920,259 - 33,939,101 (+)NCBI
RGSC_v3.41034,067,237 - 34,072,593 (+)RGD
Celera1032,555,573 - 32,561,054 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063269959   ⟹   XP_063126029
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81033,668,560 - 33,675,951 (+)NCBI
RefSeq Acc Id: NP_570090   ⟸   NM_130734
- UniProtKB: P63245 (UniProtKB/Swiss-Prot),   A6HDT8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071017   ⟸   ENSRNOT00000089829
Ensembl Acc Id: ENSRNOP00000074147   ⟸   ENSRNOT00000084232
Ensembl Acc Id: ENSRNOP00000068758   ⟸   ENSRNOT00000072179
RefSeq Acc Id: XP_063126029   ⟸   XM_063269959
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JZE6 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P63245-F1-model_v2 AlphaFold P63245 1-317 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69229 AgrOrtholog
BioCyc Gene G2FUF-25345 BioCyc
Ensembl Genes ENSRNOG00000049070 Ensembl
  ENSRNOG00000052620 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055018031 UniProtKB/Swiss-Prot
  ENSRNOG00060017834 UniProtKB/Swiss-Prot
  ENSRNOG00065005901 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000084232.2 UniProtKB/Swiss-Prot
  ENSRNOT00000089829.2 UniProtKB/TrEMBL
  ENSRNOT00055030544 UniProtKB/Swiss-Prot
  ENSRNOT00060030558 UniProtKB/Swiss-Prot
  ENSRNOT00065008853 UniProtKB/Swiss-Prot
Gene3D-CATH 2.130.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6919982 IMAGE-MGC_LOAD
InterPro Asc1/RACK1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G-protein_beta_WD-40_rep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:83427 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72712 IMAGE-MGC_LOAD
NCBI Gene 83427 ENTREZGENE
PANTHER PTHR19868 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RECEPTOR OF ACTIVATED PROTEIN C KINASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rack1 PhenoGen
PRINTS GPROTEINBRPT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE WD_REPEATS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000049070 RatGTEx
  ENSRNOG00000052620 RatGTEx
  ENSRNOG00055018031 RatGTEx
  ENSRNOG00060017834 RatGTEx
  ENSRNOG00065005901 RatGTEx
SMART WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC228638
UniProt A0A0G2JZE6 ENTREZGENE, UniProtKB/TrEMBL
  A6HDT8 ENTREZGENE, UniProtKB/TrEMBL
  P63245 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary P25388 UniProtKB/Swiss-Prot
  P99049 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-27 Rack1  receptor for activated C kinase 1  Gnb2l1  guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Gnb2l1  guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1      Name updated 1299863 APPROVED
2002-06-10 Gnb2l1  guanine nucleotide binding protein, beta polypeptide 2-like 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference