Fyn (FYN proto-oncogene, Src family tyrosine kinase) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Fyn (FYN proto-oncogene, Src family tyrosine kinase) Ictidomys tridecemlineatus
Analyze
Symbol: Fyn
Name: FYN proto-oncogene, Src family tyrosine kinase
RGD ID: 12566780
Description: ENCODES a protein that exhibits CD4 receptor binding (ortholog); CD8 receptor binding (ortholog); enzyme binding (ortholog); INVOLVED IN activated T cell proliferation (ortholog); cell surface receptor signaling pathway (ortholog); cellular response to glycine (ortholog); PARTICIPATES IN altered Reelin signaling pathway; E-cadherin signaling pathway; eicosanoid signaling pathway; ASSOCIATED WITH adult T-cell leukemia/lymphoma (ortholog); alcohol dependence (ortholog); Alzheimer's disease (ortholog); FOUND IN glutamatergic synapse (ortholog); membrane raft (ortholog); mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: FYN oncogene related to SRC, FGR, YES; tyrosine-protein kinase Fyn
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mIctTri1.hap1 - mIctTri1.hap1 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap1850,392,882 - 50,593,149 (+)NCBImIctTri1.hap1
HiC_Itri_2NW_024404946103,155,533 - 103,356,140 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936679387,387 - 443,880 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936679388,500 - 588,518 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0



Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activated T cell proliferation  (ISO)
cell surface receptor signaling pathway  (ISO)
cellular response to amyloid-beta  (IEA)
cellular response to glycine  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to L-glutamate  (ISO)
cellular response to peptide hormone stimulus  (ISO)
cellular response to platelet-derived growth factor stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
dendrite morphogenesis  (ISO)
detection of mechanical stimulus involved in sensory perception of pain  (ISO)
forebrain development  (ISO)
G protein-coupled glutamate receptor signaling pathway  (IEA)
gene expression  (ISO)
heart process  (IEA)
intracellular signal transduction  (IEA)
modulation of chemical synaptic transmission  (IEA)
natural killer cell activation  (IEA)
negative regulation of angiogenesis  (IEA)
negative regulation of dendritic spine maintenance  (IEA)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
negative regulation of gene expression  (IEA)
negative regulation of hydrogen peroxide biosynthetic process  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of protein catabolic process  (ISO)
negative regulation of protein ubiquitination  (ISO)
negative regulation of T cell activation  (IEA)
negative regulation of T cell receptor signaling pathway  (IEA)
neuron migration  (ISO)
peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of protein localization to nucleus  (ISO)
positive regulation of protein targeting to membrane  (IEA)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
protein autophosphorylation  (ISO)
protein phosphorylation  (ISO)
reelin-mediated signaling pathway  (IEA)
regulation of calcium ion import across plasma membrane  (IEA)
regulation of cell shape  (ISO)
regulation of glutamate receptor signaling pathway  (IEA)
response to amyloid-beta  (IEA)
response to cocaine  (ISO)
response to ethanol  (ISO)
response to singlet oxygen  (ISO)
response to xenobiotic stimulus  (ISO)
T cell receptor signaling pathway  (IEA)

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Fyn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap1850,392,882 - 50,593,149 (+)NCBImIctTri1.hap1
HiC_Itri_2NW_024404946103,155,533 - 103,356,140 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936679387,387 - 443,880 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936679388,500 - 588,518 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FYN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386111,660,332 - 111,873,452 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6111,660,332 - 111,873,479 (-)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh376111,981,535 - 112,194,655 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366112,089,178 - 112,301,320 (-)NCBIBuild 36Build 36hg18NCBI36
Build 346112,089,179 - 112,186,978NCBI
Celera6112,729,071 - 112,941,209 (-)NCBICelera
Cytogenetic Map6q21NCBI
HuRef6109,554,123 - 109,767,060 (-)NCBIHuRef
CHM1_16112,244,349 - 112,457,405 (-)NCBICHM1_1
T2T-CHM13v2.06112,843,350 - 113,056,537 (-)NCBIT2T-CHM13v2.0
Fyn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391039,245,735 - 39,441,377 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1039,244,851 - 39,442,227 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381039,369,743 - 39,565,381 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1039,368,855 - 39,565,381 (+)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv371039,089,605 - 39,285,187 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361039,059,502 - 39,254,797 (+)NCBIMGSCv36mm8
Celera1040,254,667 - 40,450,960 (+)NCBICelera
Cytogenetic Map10B1NCBI
cM Map1020.51NCBI
Fyn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82044,322,635 - 44,514,498 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2044,322,361 - 44,515,479 (+)EnsemblGRCr8
mRatBN7.22042,767,733 - 42,960,903 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2042,766,369 - 42,959,911 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2044,517,354 - 44,708,655 (+)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02044,176,580 - 44,367,880 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02044,909,156 - 45,110,016 (+)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd2044,358,973 - 44,554,852 (+)NCBI
Lyon_Normotensive2045,425,474 - 45,621,350 (+)NCBI
Lyon_Hypertensive2045,488,448 - 45,684,319 (+)NCBI
F344_StmMcwi2044,310,038 - 44,505,899 (+)NCBI
Rnor_6.02044,436,354 - 44,630,316 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2044,436,403 - 44,630,317 (+)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.02046,160,734 - 46,353,456 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42043,501,853 - 43,695,567 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2043,482,980 - 43,675,123 (+)NCBICelera
RGSC_v3.12043,524,863 - 43,718,578 (+)NCBI
Cytogenetic Map20q12NCBI
Fyn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541136,401,842 - 36,512,054 (-)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_00495541136,403,156 - 36,597,660 (-)NCBIChiLan1.0ChiLan1.0
FYN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25131,675,357 - 131,889,692 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16129,561,361 - 129,775,652 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06109,469,750 - 109,684,086 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16113,545,944 - 113,732,893 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6113,545,944 - 113,604,451 (-)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
FYN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11268,105,060 - 68,316,630 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1268,075,184 - 68,316,541 (-)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1267,924,675 - 68,136,151 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01268,986,784 - 69,198,525 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1268,987,778 - 69,174,188 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11268,338,226 - 68,549,311 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01268,184,783 - 68,396,306 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01268,510,644 - 68,722,405 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
FYN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl177,585,439 - 77,810,581 (-)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.1177,584,675 - 77,810,605 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2187,249,062 - 87,253,260 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2187,146,809 - 87,191,215 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1p13NCBI
FYN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap11335,844,515 - 36,051,997 (-)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_02366604034,319,593 - 34,528,593 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.11361,988,265 - 62,218,756 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1362,159,874 - 62,219,672 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Fyn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624933248,298 - 456,933 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_004624933389,627 - 456,520 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl119,535,873 - 19,749,549 (-)Ensembl
Fyn
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11839,161,813 - 39,369,515 (+)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000007385   ⟹   ENSSTOP00000006598
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936679387,387 - 443,880 (-)Ensembl
RefSeq Acc Id: XM_005337419   ⟹   XP_005337476
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
mIctTri1.hap1850,392,882 - 50,593,149 (+)NCBI
HiC_Itri_2NW_024404946103,155,538 - 103,356,140 (-)NCBI
SpeTri2.0NW_004936679388,500 - 588,518 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040283225   ⟹   XP_040139159
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
mIctTri1.hap1850,442,396 - 50,593,149 (+)NCBI
HiC_Itri_2NW_024404946103,155,533 - 103,306,654 (-)NCBI
RefSeq Acc Id: XM_040283226   ⟹   XP_040139160
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
mIctTri1.hap1850,392,882 - 50,593,149 (+)NCBI
HiC_Itri_2NW_024404946103,155,538 - 103,356,140 (-)NCBI
Protein Sequences
Protein RefSeqs XP_005337476 (Get FASTA)   NCBI Sequence Viewer  
  XP_040139159 (Get FASTA)   NCBI Sequence Viewer  
  XP_040139160 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000006598.2
  ENSSTOP00015001955
  ENSSTOP00015001956
GenBank Protein KAG3290070 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005337476   ⟸   XM_005337419
- Peptide Label: isoform X1
- UniProtKB: I3M9M0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040139159   ⟸   XM_040283225
- Peptide Label: isoform X1
- UniProtKB: I3M9M0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040139160   ⟸   XM_040283226
- Peptide Label: isoform X2
Ensembl Acc Id: ENSSTOP00000006598   ⟸   ENSSTOT00000007385
Protein Domains
Protein kinase   SH2   SH3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000007382 Ensembl, UniProtKB/TrEMBL
  ENSSTOG00015001571 ENTREZGENE
Ensembl Transcript ENSSTOT00000007385.3 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/TrEMBL
  Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Fyn/Yrk_SH2 UniProtKB/TrEMBL
  Fyn/Yrk_SH3 UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Non-receptor_tyrosine_kinases UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
KEGG Report iti:101965086 UniProtKB/TrEMBL
NCBI Gene Fyn ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE UniProtKB/TrEMBL
Pfam PK_Tyr_Ser-Thr UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PRINTS SH2DOMAIN UniProtKB/TrEMBL
  SH3DOMAIN UniProtKB/TrEMBL
  TYRKINASE UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt I3M9M0 ENTREZGENE, UniProtKB/TrEMBL