Cd8a (CD8 subunit alpha) - Rat Genome Database

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Gene: Cd8a (CD8 subunit alpha) Rattus norvegicus
Symbol: Cd8a
Name: CD8 subunit alpha (Ensembl:CD8a molecule)
RGD ID: 2316
Description: Enables protein kinase binding activity. Predicted to be involved in T cell mediated immunity; T cell receptor signaling pathway; and cytotoxic T cell differentiation. Predicted to act upstream of or within defense response to virus and positive regulation of calcium-mediated signaling. Located in cell surface. Biomarker of brain infarction. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human CD8A (CD8 subunit alpha); PARTICIPATES IN interleukin-12 signaling pathway; antigen processing and presentation pathway; primary immunodeficiency pathway; INTERACTS WITH (+)-schisandrin B; (R)-lipoic acid; 1-naphthyl isothiocyanate.
Type: protein-coding
Previously known as: CD8 antigen 32 kDa chain; CD8 antigen alpha-chain; CD8 antigen, alpha chain; CD8 antigen, alpha-chain; CD8a molecule; OX-8 membrane antigen; T-cell surface glycoprotein CD8 alpha chain
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.24103,365,804 - 103,370,041 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4103,365,804 - 103,370,040 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4108,748,755 - 108,752,992 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04104,523,859 - 104,528,097 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04103,135,733 - 103,139,970 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0499,217,640 - 99,243,352 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl499,239,115 - 99,243,351 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04163,993,814 - 164,022,356 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44104,589,922 - 104,594,159 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14104,834,402 - 104,838,639 (+)NCBI
Celera492,538,482 - 92,542,731 (+)NCBICelera
Cytogenetic Map4q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(D-Ala(2)-mephe(4)-gly-ol(5))enkephalin  (ISO)
(R)-lipoic acid  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
ammonium acetate  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP)
buta-1,3-diene  (ISO)
butanal  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
cisplatin  (ISO)
Cuprizon  (EXP)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cytarabine  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
dichloroacetic acid  (ISO)
dichloromethane  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (EXP)
endosulfan  (EXP)
ethylbenzene  (EXP)
fingolimod hydrochloride  (ISO)
flavonoids  (EXP)
fluoxetine  (ISO)
fonofos  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
glycidol  (EXP)
lipoic acid  (EXP)
methcathinone  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrofen  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
parathion  (ISO)
PCB138  (ISO)
pentanal  (ISO)
phenacetin  (EXP)
phenylhydrazine  (EXP)
pirinixic acid  (ISO)
propanal  (ISO)
raloxifene  (EXP)
resveratrol  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
terbufos  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
topotecan  (EXP)
trichloroethene  (EXP)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function


References - curated
# Reference Title Reference Citation
1. Rat CD4+CD8+ macrophages kill tumor cells through an NKG2D- and granzyme/perforin-dependent mechanism. Baba T, etal., J Immunol. 2008 Mar 1;180(5):2999-3006.
2. Molecular associations between the T-lymphocyte antigen receptor complex and the surface antigens CD2, CD4, or CD8 and CD5. Beyers AD, etal., Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):2945-9.
3. Identification of new therapeutic targets by genome-wide analysis of gene expression in the ipsilateral cortex of aged rats after stroke. Buga AM, etal., PLoS One. 2012;7(12):e50985. doi: 10.1371/journal.pone.0050985. Epub 2012 Dec 12.
4. Heat-induced reactivation of HSV-1 in latent mice: upregulation in the TG of CD83 and other immune response genes and their LAT-ICP0 locus. Clement C, etal., Invest Ophthalmol Vis Sci. 2009 Jun;50(6):2855-61. doi: 10.1167/iovs.08-2430. Epub 2009 Jan 17.
5. Effects of purified anti-Lyt-2 mAb treatment on murine listeriosis: comparative roles of Lyt-2+ and L3T4+ cells in resistance to primary and secondary infection, delayed-type hypersensitivity and adoptive transfer of resistance. Czuprynski CJ and Brown JF, Immunology. 1990 Sep;71(1):107-12.
6. Characterization of CD31 expression on murine and human neonatal T lymphocytes during development and activation. Fike AJ, etal., Pediatr Res. 2017 Jul;82(1):133-140. doi: 10.1038/pr.2017.81. Epub 2017 Apr 26.
7. Clinical features of cytotoxic CD8+ T-lymphocyte deficiency in chronic rhinosinusitis patients: a demographic and functional study. Gabra N, etal., Int Forum Allergy Rhinol. 2014 Jun;4(6):495-501. doi: 10.1002/alr.21313. Epub 2014 Mar 17.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Immune suppression in advanced chronic fascioliasis: an experimental study in a rat model. Gironès N, etal., J Infect Dis. 2007 May 15;195(10):1504-12. doi: 10.1086/514822. Epub 2007 Apr 11.
10. Lung Expression of Human Angiotensin-Converting Enzyme 2 Sensitizes the Mouse to SARS-CoV-2 Infection. Han K, etal., Am J Respir Cell Mol Biol. 2021 Jan;64(1):79-88. doi: 10.1165/rcmb.2020-0354OC.
11. Regression of human T-cell leukemia virus type I (HTLV-I)-associated lymphomas in a rat model: peptide-induced T-cell immunity. Hanabuchi S, etal., J Natl Cancer Inst. 2001 Dec 5;93(23):1775-83. doi: 10.1093/jnci/93.23.1775.
12. Purification, chain separation and sequence of the MRC OX-8 antigen, a marker of rat cytotoxic T lymphocytes. Johnson P, etal., EMBO J 1985 Oct;4(10):2539-45.
13. Depletion of regulatory T cells increases T cell brain infiltration, reactive astrogliosis, and interferon-γ gene expression in acute experimental traumatic brain injury. Krämer TJ, etal., J Neuroinflammation. 2019 Aug 5;16(1):163. doi: 10.1186/s12974-019-1550-0.
14. Immunomodulation by interleukin-4 suppresses matrix metalloproteinases and improves cardiac function in murine myocarditis. Li J, etal., Eur J Pharmacol. 2007 Jan 5;554(1):60-8. doi: 10.1016/j.ejphar.2006.08.024. Epub 2006 Aug 26.
15. Clinical and pathological investigation of severe COVID-19 patients. Li S, etal., JCI Insight. 2020 May 19. pii: 138070. doi: 10.1172/jci.insight.138070.
16. In vivo antiviral host transcriptional response to SARS-CoV-2 by viral load, sex, and age. Lieberman NAP, etal., PLoS Biol. 2020 Sep 8;18(9):e3000849. doi: 10.1371/journal.pbio.3000849. eCollection 2020 Sep.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Better-surviving liver grafts by the injection of anti-CD2 antibody: the important roles of host CD8+ and CD2+CD28+ T cells in chronic graft rejection and beta type platelet-derived growth factor receptor (PDGFR-beta) expression on apoptotic liver grafts. Nakatsuji T Tohoku J Exp Med. 1999 Mar;187(3):215-25.
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. Regulation of CD8 expression in mast cells by exogenous or endogenous nitric oxide. Nohara O, etal., J Immunol 2001 Nov 15;167(10):5935-9.
21. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
22. Experimental antibacterial therapy with puroindolines, lactoferrin and lysozyme in Listeria monocytogenes-infected mice. Palumbo D, etal., Microbes Infect. 2010 Jul;12(7):538-45. doi: 10.1016/j.micinf.2010.03.010. Epub 2010 Mar 27.
23. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
24. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
25. Supplementing suckling rats with whey protein concentrate modulates the immune response and ameliorates rat rotavirus-induced diarrhea. Pérez-Cano FJ, etal., J Nutr. 2008 Dec;138(12):2392-8. doi: 10.3945/jn.108.093856.
26. GOA pipeline RGD automated data pipeline
27. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. Upregulation of major histocompatibility complex (MHC) antigen in nephritis associated with murine malaria infection. Rui-Mei L, etal., J Pathol. 1998 Jun;185(2):212-8. doi: 10.1002/(SICI)1096-9896(199806)185:2<212::AID-PATH61>3.0.CO;2-T.
30. Robust CD8+ T-cell proliferation and diversification after mogamulizumab in patients with adult T-cell leukemia-lymphoma. Saito M, etal., Blood Adv. 2020 May 26;4(10):2180-2191. doi: 10.1182/bloodadvances.2020001641.
31. Transcriptional analysis of immune genes in Epstein-Barr virus-associated gastric cancer and association with clinical outcomes. Sundar R, etal., Gastric Cancer. 2018 Nov;21(6):1064-1070. doi: 10.1007/s10120-018-0851-9. Epub 2018 Jun 18.
32. Association between Tim‑3 and Gal‑9 expression and gastric cancer prognosis. Wang Y, etal., Oncol Rep. 2018 Oct;40(4):2115-2126. doi: 10.3892/or.2018.6627. Epub 2018 Aug 6.
33. Phenotype and function of GM-CSF independent dendritic cells generated by long-term propagation of rat bone marrow cells. Yan H, etal., Cell Immunol. 2004 Jun;229(2):117-29. doi: 10.1016/j.cellimm.2004.07.006.
Additional References at PubMed
PMID:1673361   PMID:1908233   PMID:2493728   PMID:2784196   PMID:6610701   PMID:7589135   PMID:8688082   PMID:8755570   PMID:8788039   PMID:9177355   PMID:9208839   PMID:9830036  
PMID:10072077   PMID:10648399   PMID:10704459   PMID:10943842   PMID:11131152   PMID:12477932   PMID:14568922   PMID:14609575   PMID:15240714   PMID:15294943   PMID:15322158   PMID:15489334  
PMID:15728238   PMID:15749886   PMID:15795238   PMID:15843532   PMID:16287714   PMID:16455951   PMID:16973387   PMID:17082577   PMID:17213291   PMID:17277142   PMID:17341584   PMID:17357106  
PMID:18776904   PMID:18836449   PMID:18984740   PMID:19349303   PMID:19565478   PMID:19723499   PMID:19838199   PMID:19934022   PMID:20709950   PMID:21460847   PMID:21508411   PMID:22068125  
PMID:22072979   PMID:24257693   PMID:31681288  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.24103,365,804 - 103,370,041 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4103,365,804 - 103,370,040 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4108,748,755 - 108,752,992 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04104,523,859 - 104,528,097 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04103,135,733 - 103,139,970 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0499,217,640 - 99,243,352 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl499,239,115 - 99,243,351 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04163,993,814 - 164,022,356 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44104,589,922 - 104,594,159 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14104,834,402 - 104,838,639 (+)NCBI
Celera492,538,482 - 92,542,731 (+)NCBICelera
Cytogenetic Map4q32NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38286,784,605 - 86,808,396 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl286,784,610 - 86,808,396 (-)EnsemblGRCh38hg38GRCh38
GRCh37287,011,728 - 87,035,519 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36286,865,239 - 86,871,638 (-)NCBINCBI36Build 36hg18NCBI36
Build 34286,923,391 - 86,929,725NCBI
Celera286,839,534 - 86,863,331 (-)NCBICelera
Cytogenetic Map2p11.2NCBI
HuRef286,898,000 - 86,921,798 (-)NCBIHuRef
CHM1_1286,941,749 - 86,965,554 (-)NCBICHM1_1
T2T-CHM13v2.0286,786,504 - 86,810,303 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39671,350,411 - 71,356,155 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl671,350,411 - 71,356,157 (+)EnsemblGRCm39 Ensembl
GRCm38671,373,427 - 71,379,171 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl671,373,427 - 71,379,173 (+)EnsemblGRCm38mm10GRCm38
MGSCv37671,323,421 - 71,329,165 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36671,302,936 - 71,308,680 (+)NCBIMGSCv36mm8
Celera673,452,794 - 73,458,537 (+)NCBICelera
Cytogenetic Map6C1NCBI
cM Map632.14NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_004955424952,502 - 978,636 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955424952,595 - 979,159 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan12A39,582,466 - 39,606,086 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A86,832,559 - 86,855,772 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A88,376,411 - 88,383,519 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A88,377,722 - 88,382,635 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11738,396,022 - 38,400,508 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1738,369,414 - 38,400,508 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1738,080,864 - 38,085,351 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01739,127,938 - 39,132,423 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1739,127,889 - 39,132,423 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11738,294,729 - 38,299,212 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01738,330,601 - 38,335,086 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01738,679,136 - 38,683,623 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440629279,968,389 - 79,973,360 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936712885,458 - 890,852 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936712885,301 - 891,247 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl357,998,891 - 58,029,760 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1357,999,228 - 58,029,768 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2360,852,723 - 60,859,977 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11418,878,013 - 18,885,183 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1418,878,622 - 18,883,885 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666080896,572 - 903,593 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_00462474916,564,944 - 16,569,890 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Cd8a
11 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:47
Interacting mature miRNAs:49
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1578657Bss12Bone structure and strength QTL 128.9femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)460220938105220938Rat
1578658Bss13Bone structure and strength QTL 138femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)460220938105220938Rat
2300179Bmd50Bone mineral density QTL 505.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)460928534105928534Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658115089733Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462879517107879517Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)percent change in mean arterial blood pressure (CMO:0002035)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)percent change in systolic blood pressure (CMO:0000747)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in pulse pressure (CMO:0001882)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)462933508114921294Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)470808386115808386Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)470808386115808386Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473169846132642728Rat
724522Bp146Blood pressure QTL 1462.20.0021arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)473630210118630210Rat
2302051Pia28Pristane induced arthritis QTL 285.30.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)473630210118630210Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)478878504123878504Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)478881294117676292Rat
738015Pia9Pristane induced arthritis QTL 94.50.048joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)480694870125694870Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)481006124120102625Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)481192555126192555Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)484728680129854654Rat
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)486730991131730991Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)487327165132327165Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)487327165132327165Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)490850165135850165Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)495174120140174120Rat
8662350Eae35Experimental allergic encephalomyelitis QTL 356.2blood tumor necrosis factor amount (VT:0008552)inflammatory exudate tumor necrosis factor level (CMO:0001435)4100834579103761084Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4103194656148194656Rat
2317588Eae27Experimental allergic encephalomyelitis QTL 27nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)4103194805112478794Rat


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 4 4
Medium 2 4 15 3 10
Low 1 43 31 23 23 8 8 25 29 27 1 8
Below cutoff 18 18 18 2 39 6 11


RefSeq Acc Id: ENSRNOT00000009515   ⟹   ENSRNOP00000009516
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4103,365,804 - 103,370,040 (+)Ensembl
Rnor_6.0 Ensembl499,239,115 - 99,243,351 (+)Ensembl
RefSeq Acc Id: NM_031538   ⟹   NP_113726
Rat AssemblyChrPosition (strand)Source
mRatBN7.24103,365,804 - 103,370,041 (+)NCBI
Rnor_6.0499,239,115 - 99,243,352 (+)NCBI
Rnor_5.04163,993,814 - 164,022,356 (+)NCBI
RGSC_v3.44104,589,922 - 104,594,159 (+)RGD
Celera492,538,482 - 92,542,731 (+)RGD
RefSeq Acc Id: NP_113726   ⟸   NM_031538
- Peptide Label: precursor
- UniProtKB: P07725 (UniProtKB/Swiss-Prot),   A6IA73 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000009516   ⟸   ENSRNOT00000009515
Protein Domains
Ig-like   Ig-like V-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P07725-F1-model_v2 AlphaFold P07725 1-236 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13693113
Promoter ID:EPDNEW_R3638
Type:initiation region
Description:CD8a molecule
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0499,239,116 - 99,239,176EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2316 AgrOrtholog
BioCyc Gene G2FUF-44184 BioCyc
Ensembl Genes ENSRNOG00000007178 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055020405 UniProtKB/Swiss-Prot
  ENSRNOG00060014674 UniProtKB/Swiss-Prot
  ENSRNOG00065005181 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000009515 ENTREZGENE
  ENSRNOT00000009515.5 UniProtKB/Swiss-Prot
  ENSRNOT00055034849 UniProtKB/Swiss-Prot
  ENSRNOT00060025082 UniProtKB/Swiss-Prot
  ENSRNOT00065007608 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CD8_asu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24930 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cd8a PhenoGen
RatGTEx ENSRNOG00000007178 RatGTEx
  ENSRNOG00055020405 RatGTEx
  ENSRNOG00060014674 RatGTEx
  ENSRNOG00065005181 RatGTEx
SMART SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Immunoglobulin UniProtKB/TrEMBL, UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-01-27 Cd8a  CD8 subunit alpha  Cd8a  CD8a molecule  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Cd8a  CD8a molecule  Cd8a  CD8 antigen, alpha chain  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Cd8a  CD8 antigen, alpha-chain      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed on alveolar macrophages and peritoneal mast cells 728221