Enables protein kinase binding activity. Predicted to be involved in T cell mediated immunity; T cell receptor signaling pathway; and cytotoxic T cell differentiation. Predicted to act upstream of or within defense response to virus and positive regulation of calcium-mediated signaling. Located in cell surface. Biomarker of brain infarction. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human CD8A (CD8 subunit alpha); PARTICIPATES IN interleukin-12 signaling pathway; antigen processing and presentation pathway; primary immunodeficiency pathway; INTERACTS WITH (+)-schisandrin B; (R)-lipoic acid; 1-naphthyl isothiocyanate.
[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CD8A mRNA and resveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CD8A protein]
[dan-shen root extract co-treated with Andrographis paniculata extract] inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency co-treated with Particulate Matter] results in decreased expression of CD8A mRNA] and [Oxygen deficiency co-treated with Blood Glucose deficiency co-treated with Particulate Matter] results in decreased expression of CD8A mRNA
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of CD8A mRNA and [Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of CD8A mRNA
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of CD8A mRNA and [Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of CD8A mRNA
Effects of purified anti-Lyt-2 mAb treatment on murine listeriosis: comparative roles of Lyt-2+ and L3T4+ cells in resistance to primary and secondary infection, delayed-type hypersensitivity and adoptive transfer of resistance.
Depletion of regulatory T cells increases T cell brain infiltration, reactive astrogliosis, and interferon-γ gene expression in acute experimental traumatic brain injury.
Better-surviving liver grafts by the injection of anti-CD2 antibody: the important roles of host CD8+ and CD2+CD28+ T cells in chronic graft rejection and beta type platelet-derived growth factor receptor (PDGFR-beta) expression on apoptotic liver grafts.
