Thy1 (Thy-1 cell surface antigen) - Rat Genome Database

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Gene: Thy1 (Thy-1 cell surface antigen) Rattus norvegicus
Analyze
Symbol: Thy1
Name: Thy-1 cell surface antigen
RGD ID: 3860
Description: Enables GPI anchor binding activity; GTPase activator activity; and protein kinase binding activity. Involved in several processes, including T cell receptor signaling pathway; focal adhesion assembly; and positive regulation of release of sequestered calcium ion into cytosol. Acts upstream of or within with a positive effect on cell-cell signaling and negative regulation of neuron projection regeneration. Located in several cellular components, including growth cone; neuron projection membrane; and neuronal cell body membrane. Biomarker of retinal disease and retinal ischemia. Orthologous to human THY1 (Thy-1 cell surface antigen); PARTICIPATES IN interleukin-4 signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-acetamidofluorene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CD7; CD90; thy-1 antigen; thy-1 glycoprotein; Thy-1 membrane glycoprotein; Thy-1 protein; thymus cell antigen 1, theta; Thymus cell surface antigen
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8853,286,396 - 53,291,541 (+)NCBIGRCr8
mRatBN7.2844,389,495 - 44,394,688 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl844,389,513 - 44,394,659 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx849,887,923 - 49,892,732 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0848,166,622 - 48,171,433 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0846,034,211 - 46,039,022 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0848,382,121 - 48,387,271 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl848,382,121 - 48,386,935 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0846,998,623 - 47,003,773 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4847,027,721 - 47,031,857 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1847,036,486 - 47,040,623 (+)NCBI
Celera843,976,742 - 43,981,520 (+)NCBICelera
RH 3.4 Map21191.8RGD
Cytogenetic Map8q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(20S)-ginsenoside Rg3  (ISO)
(R)-adrenaline  (ISO)
(R)-noradrenaline  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-acetamidofluorene  (EXP)
2-bromohexadecanoic acid  (ISO)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
albuterol  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
beclomethasone  (ISO)
benzo[a]pyrene  (ISO)
beta-cyclodextrin  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bortezomib  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
capsazepine  (EXP)
carbon nanotube  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
cytarabine  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
dibutyl phthalate  (EXP,ISO)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (EXP,ISO)
dimethylselenide  (ISO)
diquat  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
formoterol fumarate  (ISO)
genistein  (EXP)
hydralazine  (ISO)
hydroxyl  (ISO)
iohexol  (ISO)
iopamidol  (ISO)
irinotecan  (ISO)
isoprenaline  (ISO)
ketamine  (EXP)
L-1,4-dithiothreitol  (ISO)
mercury dichloride  (ISO)
Mesaconitine  (EXP)
Methanandamide  (EXP)
methylmercury(1+)  (ISO)
monocrotaline  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
nitrofen  (EXP)
nitroglycerin  (EXP)
ochratoxin A  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
PCB138  (ISO)
pentanal  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
poly(I:C)  (EXP)
progesterone  (ISO)
propanal  (ISO)
propranolol  (ISO)
raloxifene  (EXP,ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP)
rimonabant  (EXP)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
thimerosal  (ISO)
toluene  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (EXP)
triclosan  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
Y-27632  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Signaling triggered by Thy-1 interaction with beta 3 integrin on astrocytes is an essential step towards unraveling neuronal Thy-1 function. Avalos AM, etal., Biol Res. 2002;35(2):231-8.
2. Neuronal Thy-1 induces astrocyte adhesion by engaging syndecan-4 in a cooperative interaction with alphavbeta3 integrin that activates PKCalpha and RhoA. Avalos AM, etal., J Cell Sci. 2009 Oct 1;122(Pt 19):3462-71. doi: 10.1242/jcs.034827. Epub 2009 Sep 1.
3. Thy-1 regulates fibroblast focal adhesions, cytoskeletal organization and migration through modulation of p190 RhoGAP and Rho GTPase activity. Barker TH, etal., Exp Cell Res. 2004 May 1;295(2):488-96.
4. Fibrin biopolymer as scaffold candidate to treat bone defects in rats. Cassaro CV, etal., J Venom Anim Toxins Incl Trop Dis. 2019 Nov 4;25:e20190027. doi: 10.1590/1678-9199-JVATITD-2019-0027. eCollection 2019.
5. Baicalein protects against retinal ischemia by antioxidation, antiapoptosis, downregulation of HIF-1alpha, VEGF, and MMP-9 and upregulation of HO-1. Chao HM, etal., J Ocul Pharmacol Ther. 2013 Jul-Aug;29(6):539-49. doi: 10.1089/jop.2012.0179. Epub 2013 Mar 28.
6. Role of Thy-1 in in vivo and in vitro neural development and regeneration of dorsal root ganglionic neurons. Chen CH, etal., J Cell Biochem. 2005 Mar 1;94(4):684-94.
7. Changes in ocular aquaporin-4 (AQP4) expression following retinal injury. Dibas A, etal., Mol Vis. 2008 Sep 25;14:1770-83.
8. Thy-1-mediated activation of rat mast cells: the role of Thy-1 membrane microdomains. Draberova L, etal., Immunology. 1996 Jan;87(1):141-8.
9. Aggregation of Thy-1 glycoprotein induces thymocyte apoptosis through activation of CPP32-like proteases. Fujita N, etal., Exp Cell Res. 1997 May 1;232(2):400-6.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. Differential expression of platelet-derived growth factor-alpha receptor by Thy-1(-) and Thy-1(+) lung fibroblasts. Hagood JS, etal., Am J Physiol. 1999 Jul;277(1 Pt 1):L218-24.
13. Direct Thy-1/alphaVbeta3 integrin interaction mediates neuron to astrocyte communication. Hermosilla T, etal., Biochim Biophys Acta. 2008 Jun;1783(6):1111-20. doi: 10.1016/j.bbamcr.2008.01.034. Epub 2008 Feb 20.
14. Astrocytic aVß3 integrin inhibits neurite outgrowth and promotes retraction of neuronal processes by clustering Thy-1. Herrera-Molina R, etal., PLoS One. 2012;7(3):e34295. doi: 10.1371/journal.pone.0034295. Epub 2012 Mar 30.
15. Thymocytes in Thy-1-/- mice show augmented TCR signaling and impaired differentiation. Hueber AO, etal., Curr Biol. 1997 Sep 1;7(9):705-8.
16. Characterization of a gel-separated unknown glycoprotein by liquid chromatography/multistage tandem mass spectrometry: analysis of rat brain Thy-1 separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Itoh S, etal., J Chromatogr A. 2005 Nov 11;1094(1-2):105-17. Epub 2005 Oct 5.
17. Thy-1 functions as a signal transduction molecule in T lymphocytes and transfected B lymphocytes. Kroczek RA, etal., Nature. 1986 Jul 10-16;322(6075):181-4.
18. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
19. Differential requirement for protein tyrosine kinase Fyn in the functional activation of antigen-specific T lymphocyte clones through the TCR or Thy-1. Lancki DW, etal., J Immunol. 1995 May 1;154(9):4363-70.
20. Proteomic characterisation of neuronal sphingolipid-cholesterol microdomains: role in plasminogen activation. Ledesma MD, etal., Brain Res. 2003 Oct 10;987(1):107-16.
21. Thy-1 binds to integrin beta(3) on astrocytes and triggers formation of focal contact sites. Leyton L, etal., Curr Biol. 2001 Jul 10;11(13):1028-38.
22. Multiple receptor tyrosine kinases are expressed in adult rat retinal ganglion cells as revealed by single-cell degenerate primer polymerase chain reaction. Lindqvist N, etal., Ups J Med Sci. 2010 Feb;115(1):65-80. doi: 10.3109/03009731003597119.
23. Functionally different GPI proteins are organized in different domains on the neuronal surface. Madore N, etal., EMBO J. 1999 Dec 15;18(24):6917-26.
24. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
25. Rat Thy-1 antigen has a hydrophobic segment at the carboxyl terminus. Moriuchi T and Silver J, FEBS Lett 1984 Dec 3;178(1):105-8.
26. Thy-1 cDNA sequence suggests a novel regulatory mechanism. Moriuchi T, etal., Nature 1983 Jan 6;301(5895):80-2.
27. Thy-1 molecule associates with protein tyrosine kinase(s) in rat mesangial cells. Narisawa-Saito M, etal., Clin Exp Immunol. 1996 Oct;106(1):86-90.
28. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
29. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
30. GOA pipeline RGD automated data pipeline
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Thy-1: a hydrophobic transmembrane segment at the carboxyl terminus. Seki T, etal., Fed Proc 1985 Oct;44(13):2865-9.
33. Structural organization of the rat thy-1 gene. Seki T, etal., Nature 1985 Feb 7-13;313(6002):485-7.
34. Identification of genomic regions controlling experimental autoimmune uveoretinitis in rats. Sun SH, etal., Int Immunol 1999 Apr;11(4):529-34
35. Characterization of the interaction between galectin-1 and lymphocyte glycoproteins CD45 and Thy-1. Symons A, etal., Glycobiology. 2000 Jun;10(6):559-63.
36. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
37. Phenotype and function of GM-CSF independent dendritic cells generated by long-term propagation of rat bone marrow cells. Yan H, etal., Cell Immunol. 2004 Jun;229(2):117-29. doi: 10.1016/j.cellimm.2004.07.006.
Additional References at PubMed
PMID:2857501   PMID:2886334   PMID:2897081   PMID:6118137   PMID:7983148   PMID:9576104   PMID:9749990   PMID:10567740   PMID:14660659   PMID:14707049   PMID:14757759   PMID:15004192  
PMID:15220352   PMID:15569310   PMID:15677725   PMID:16455951   PMID:16632291   PMID:16960126   PMID:17082577   PMID:17341485   PMID:17395197   PMID:17486586   PMID:17634366   PMID:17647294  
PMID:17884967   PMID:19056867   PMID:19575449   PMID:20124093   PMID:20724553   PMID:20855773   PMID:21423176   PMID:21502139   PMID:21700703   PMID:22206666   PMID:22281825   PMID:23376485  
PMID:23533145   PMID:24029230   PMID:24374733   PMID:25002582   PMID:25304966   PMID:27765629   PMID:29341439   PMID:29476059   PMID:30049932   PMID:31841640  


Genomics

Comparative Map Data
Thy1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8853,286,396 - 53,291,541 (+)NCBIGRCr8
mRatBN7.2844,389,495 - 44,394,688 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl844,389,513 - 44,394,659 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx849,887,923 - 49,892,732 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0848,166,622 - 48,171,433 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0846,034,211 - 46,039,022 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0848,382,121 - 48,387,271 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl848,382,121 - 48,386,935 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0846,998,623 - 47,003,773 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4847,027,721 - 47,031,857 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1847,036,486 - 47,040,623 (+)NCBI
Celera843,976,742 - 43,981,520 (+)NCBICelera
RH 3.4 Map21191.8RGD
Cytogenetic Map8q22NCBI
THY1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811119,415,476 - 119,424,985 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11119,415,476 - 119,424,985 (-)EnsemblGRCh38hg38GRCh38
GRCh3711119,286,186 - 119,295,695 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611118,794,098 - 118,799,064 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411118,794,097 - 118,799,064NCBI
Celera11116,449,333 - 116,454,924 (-)NCBICelera
Cytogenetic Map11q23.3NCBI
HuRef11115,230,310 - 115,235,710 (-)NCBIHuRef
CHM1_111119,175,213 - 119,180,804 (-)NCBICHM1_1
T2T-CHM13v2.011119,437,019 - 119,446,528 (-)NCBIT2T-CHM13v2.0
Thy1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39943,954,681 - 43,959,876 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl943,954,681 - 43,959,876 (+)EnsemblGRCm39 Ensembl
GRCm38944,043,384 - 44,048,579 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl944,043,384 - 44,048,579 (+)EnsemblGRCm38mm10GRCm38
MGSCv37943,851,467 - 43,856,662 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36943,796,949 - 43,799,573 (+)NCBIMGSCv36mm8
Celera941,300,956 - 41,306,126 (+)NCBICelera
Cytogenetic Map9A5.1NCBI
cM Map924.52NCBI
Thy1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541220,480,284 - 20,484,958 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541220,480,284 - 20,484,958 (-)NCBIChiLan1.0ChiLan1.0
THY1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29120,120,258 - 120,125,745 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111121,223,735 - 121,228,812 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011114,253,535 - 114,259,495 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111118,180,717 - 118,186,901 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11118,180,717 - 118,186,901 (-)Ensemblpanpan1.1panPan2
THY1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1514,503,902 - 14,509,113 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl514,503,902 - 14,509,113 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha514,557,503 - 14,562,714 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0514,447,441 - 14,452,656 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl514,447,423 - 14,452,742 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1514,585,674 - 14,590,877 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0514,489,710 - 14,494,914 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0514,529,873 - 14,535,084 (+)NCBIUU_Cfam_GSD_1.0
Thy1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947101,402,496 - 101,408,588 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365424,323,408 - 4,330,077 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365424,323,905 - 4,329,940 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
THY1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl946,607,494 - 46,612,269 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1946,607,022 - 46,612,691 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2951,639,467 - 51,644,315 (-)NCBISscrofa10.2Sscrofa10.2susScr3
THY1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11110,787,213 - 110,791,536 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1110,783,877 - 110,791,569 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604315,243,058 - 15,247,526 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Thy1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478414,780,698 - 14,784,897 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478414,779,533 - 14,784,315 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Thy1
50 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:406
Count of miRNA genes:226
Interacting mature miRNAs:259
Transcripts:ENSRNOT00000008685
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815458482492Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1359021Bp271Blood pressure QTL 2711.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82664491246711092Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84186701070386132Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)82824291253961020Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
5684993Bmd84Bone mineral density QTL 844.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)84269268450095447Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82950266550095447Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)82720571554998217Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat

Markers in Region
D8Arb8  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2844,392,307 - 44,392,577 (+)MAPPERmRatBN7.2
Rnor_6.0848,384,895 - 48,385,160NCBIRnor6.0
Rnor_5.0847,001,397 - 47,001,662UniSTSRnor5.0
RGSC_v3.4847,030,445 - 47,030,711RGDRGSC3.4
RGSC_v3.4847,030,446 - 47,030,711UniSTSRGSC3.4
RGSC_v3.1847,039,211 - 47,039,477RGD
Celera843,979,516 - 43,979,745UniSTS
SHRSP x BN Map834.61UniSTS
SHRSP x BN Map834.61RGD
FHH x ACI Map834.68RGD
Cytogenetic Map8q22UniSTS
D8Wox34  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2844,392,321 - 44,392,645 (+)MAPPERmRatBN7.2
Rnor_6.0848,384,909 - 48,385,228NCBIRnor6.0
Rnor_5.0847,001,411 - 47,001,730UniSTSRnor5.0
RGSC_v3.4847,030,460 - 47,030,779UniSTSRGSC3.4
Celera843,979,530 - 43,979,813UniSTS
Cytogenetic Map8q22UniSTS
PMC22863P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2844,392,856 - 44,393,505 (+)MAPPERmRatBN7.2
Rnor_6.0848,385,440 - 48,386,088NCBIRnor6.0
Rnor_5.0847,001,942 - 47,002,590UniSTSRnor5.0
RGSC_v3.4847,030,991 - 47,031,639UniSTSRGSC3.4
Celera843,980,025 - 43,980,673UniSTS
Cytogenetic Map8q22UniSTS
RH94841  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2844,393,886 - 44,394,099 (+)MAPPERmRatBN7.2
Rnor_6.0848,386,470 - 48,386,682NCBIRnor6.0
Rnor_5.0847,002,972 - 47,003,184UniSTSRnor5.0
RGSC_v3.4847,032,021 - 47,032,233UniSTSRGSC3.4
Celera843,981,055 - 43,981,267UniSTS
RH 3.4 Map21191.8UniSTS
Cytogenetic Map8q22UniSTS
BE096371  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2844,393,786 - 44,393,954 (+)MAPPERmRatBN7.2
Rnor_6.0848,386,370 - 48,386,537NCBIRnor6.0
Rnor_5.0847,002,872 - 47,003,039UniSTSRnor5.0
RGSC_v3.4847,031,921 - 47,032,088UniSTSRGSC3.4
Celera843,980,955 - 43,981,122UniSTS
RH 3.4 Map8423.5UniSTS
Cytogenetic Map8q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 4
Medium 3 6 21 6 13 6 3 3 60 28 28 1 3
Low 37 31 30 6 30 5 8 10 7 13 10 5
Below cutoff 5 5 5

Sequence


Ensembl Acc Id: ENSRNOT00000008685   ⟹   ENSRNOP00000008685
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl844,389,513 - 44,394,659 (+)Ensembl
Rnor_6.0 Ensembl848,382,121 - 48,386,935 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095277   ⟹   ENSRNOP00000079974
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl844,390,079 - 44,394,659 (+)Ensembl
RefSeq Acc Id: NM_012673   ⟹   NP_036805
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8853,286,396 - 53,291,210 (+)NCBI
mRatBN7.2844,389,534 - 44,394,352 (+)NCBI
Rnor_6.0848,382,121 - 48,386,935 (+)NCBI
Rnor_5.0846,998,623 - 47,003,773 (+)NCBI
RGSC_v3.4847,027,721 - 47,031,857 (+)RGD
Celera843,976,742 - 43,981,520 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017595476   ⟹   XP_017450965
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8853,286,448 - 53,291,541 (+)NCBI
mRatBN7.2844,389,615 - 44,394,688 (+)NCBI
Rnor_6.0848,382,202 - 48,387,271 (+)NCBI
Sequence:
RefSeq Acc Id: NP_036805   ⟸   NM_012673
- Peptide Label: preproprotein
- UniProtKB: P01830 (UniProtKB/Swiss-Prot),   A6J3V0 (UniProtKB/TrEMBL),   A0A8I5ZPP2 (UniProtKB/TrEMBL),   A6J3U9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450965   ⟸   XM_017595476
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q3U4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008685   ⟸   ENSRNOT00000008685
Ensembl Acc Id: ENSRNOP00000079974   ⟸   ENSRNOT00000095277
Protein Domains
Ig-like   Ig-like V-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P01830-F1-model_v2 AlphaFold P01830 1-161 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695880
Promoter ID:EPDNEW_R6405
Type:multiple initiation site
Name:Thy1_1
Description:Thy-1 cell surface antigen
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0848,382,140 - 48,382,200EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3860 AgrOrtholog
BioCyc Gene G2FUF-30742 BioCyc
Ensembl Genes ENSRNOG00000006604 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055020020 UniProtKB/Swiss-Prot
  ENSRNOG00060019171 UniProtKB/Swiss-Prot
  ENSRNOG00065022864 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008685.4 UniProtKB/TrEMBL
  ENSRNOT00000095277.1 UniProtKB/TrEMBL
  ENSRNOT00055034179 UniProtKB/Swiss-Prot
  ENSRNOT00060033186 UniProtKB/Swiss-Prot
  ENSRNOT00065039071 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Immunoglobulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THY1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24832 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24832 ENTREZGENE
PANTHER PTHR19226 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THY-1 MEMBRANE GLYCOPROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PF00047 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Thy1 PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006604 RatGTEx
  ENSRNOG00055020020 RatGTEx
  ENSRNOG00060019171 RatGTEx
  ENSRNOG00065022864 RatGTEx
SMART IGv UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC216837
UniProt A0A8I5ZPP2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q3U4 ENTREZGENE, UniProtKB/TrEMBL
  A6J3U9 ENTREZGENE, UniProtKB/TrEMBL
  A6J3V0 ENTREZGENE, UniProtKB/TrEMBL
  P01830 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Thy1  Thy-1 cell surface antigen  Thy1  thymus cell antigen 1, theta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Thy1  Thymus cell surface antigen      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression predominant expression is in brain, thymocytes and T-cells 730221