Lgals1 (galectin 1) - Rat Genome Database

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Gene: Lgals1 (galectin 1) Rattus norvegicus
Analyze
Symbol: Lgals1
Name: galectin 1
RGD ID: 69355
Description: Enables identical protein binding activity; lactose binding activity; and laminin binding activity. Involved in several processes, including cellular response to glucose stimulus; positive regulation of erythrocyte aggregation; and response to isolation stress. Located in cell surface. Biomarker of B-cell lymphoma; extrahepatic cholestasis; and lipoid nephrosis. Orthologous to human LGALS1 (galectin 1); INTERACTS WITH 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 14 kDa lectin; beta-galactoside-binding lectin; beta-galactoside-binding lectin L-14-I; gal-1; galaptin; galectin-1; lactose-binding lectin 1; lectin, galactose binding, soluble 1; lectin, galactoside-binding, soluble, 1; RL 14.5; S-Lac lectin 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27110,485,239 - 110,488,345 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7110,481,392 - 110,488,345 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7112,234,764 - 112,237,858 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07114,458,284 - 114,461,378 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07114,426,881 - 114,429,988 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07120,153,184 - 120,156,290 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7120,153,184 - 120,156,289 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07120,144,875 - 120,147,981 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47116,893,662 - 116,896,768 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17116,927,891 - 116,930,997 (+)NCBI
Celera7106,819,373 - 106,822,479 (+)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
8-Br-cAMP  (ISO)
acetohydrazide  (ISO)
aflatoxin B1  (ISO)
alachlor  (EXP)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
camptothecin  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chrysene  (ISO)
cisplatin  (EXP,ISO)
clobetasol  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
corn oil  (EXP)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
D-penicillamine  (EXP)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
dicrotophos  (ISO)
dihydroartemisinin  (ISO)
dimethyl sulfoxide  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
Enterolactone  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
fenamidone  (ISO)
fenofibrate  (ISO)
fipronil  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glycidyl methacrylate  (ISO)
haloperidol  (ISO)
hyaluronic acid  (EXP)
hydralazine  (ISO)
hydrogen peroxide  (EXP)
ibuprofen  (ISO)
imidazopyrazole  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indole-3-methanol  (EXP)
inulin  (ISO)
isobutanol  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lidocaine  (ISO)
lipopolysaccharide  (ISO)
malathion  (ISO)
microcystin RR  (ISO)
microcystin-LR  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP,ISO)
naphthalene  (ISO)
nickel subsulfide  (EXP)
nicotine  (ISO)
ouabain  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
PCB138  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenanthrene  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
progesterone  (ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
sodium fluoride  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP)
tamibarotene  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
tetradecane  (EXP)
tetraphene  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vorinostat  (ISO)
zearalenone  (ISO)
zidovudine  (ISO)
zinc oxide  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell surface  (IDA)
cytoplasm  (IEA)
cytosol  (IEA,ISO)
extracellular space  (IBA,IEA,ISO)
galectin complex  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Sequence of a full-length cDNA for rat lung beta-galactoside-binding protein: primary and secondary structure of the lectin. Clerch LB, etal., Biochemistry 1988 Jan 26;27(2):692-9.
2. Endogenous muscle lectin inhibits myoblast adhesion to laminin. Cooper DN, etal., J Cell Biol. 1991 Dec;115(5):1437-48.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Inflammation-induced modulation of cellular galectin-1 and -3 expression in a model of rat peritonitis. Gil CD, etal., Inflamm Res. 2006 Mar;55(3):99-107.
5. Combined genealogical, mapping, and expression approaches to identify spontaneously hypertensive rat hypertension candidate genes. Hinojos CA, etal., Hypertension 2005 Apr;45(4):698-704. Epub 2005 Feb 14.
6. Proteomics-based identification of differentially-expressed proteins including galectin-1 in the blood plasma of type 2 diabetic patients. Liu X, etal., J Proteome Res. 2009 Mar;8(3):1255-62.
7. The aryl hydrocarbon receptor agonist 3,3',4,4',5-pentachlorobiphenyl induces distinct patterns of gene expression between hepatoma and glioma cells: chromatin remodeling as a mechanism for selective effects. Maier MS, etal., Neurotoxicology. 2007 May;28(3):594-612. Epub 2007 Jan 13.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. Identification of a lectin causing the degeneration of neuronal processes using engineered embryonic stem cells. Plachta N, etal., Nat Neurosci. 2007 Jun;10(6):712-9. Epub 2007 May 7.
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Expression of galectin-1, a new component of slit diaphragm, is altered in minimal change nephrotic syndrome. Shimizu M, etal., Lab Invest. 2009 Feb;89(2):178-95. Epub 2008 Dec 15.
14. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
15. Galectin-1 expression in innervated and denervated skeletal muscle. Svensson A and Tagerud S, Cell Mol Biol Lett. 2009;14(1):128-38. Epub 2008 Oct 10.
16. Characterization of the interaction between galectin-1 and lymphocyte glycoproteins CD45 and Thy-1. Symons A, etal., Glycobiology. 2000 Jun;10(6):559-63.
17. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
18. Oxidation and chemical modification of lung beta-galactoside-specific lectin. Whitney PL, etal., Biochem J. 1986 Sep 15;238(3):683-9.
19. Factors released from cholestatic rat livers possibly involved in inducing bone marrow hepatic stem cell priming. Xu J, etal., Stem Cells Dev. 2008 Feb;17(1):143-55.
20. Low-dose cyclophosphamide modulates galectin-1 expression and function in an experimental rat lymphoma model. Zacarias Fluck MF, etal., Cancer Immunol Immunother. 2007 Feb;56(2):237-48. Epub 2006 May 30.
21. Proteomic changes of PC12 cells treated with proteasomal inhibitor PSI. Zhang L, etal., Brain Res. 2007 Jun 11;1153:196-203. Epub 2007 Mar 30.
22. Social isolation in rats inhibits oxidative metabolism, decreases the content of mitochondrial K-Ras and activates mitochondrial hexokinase. Zhuravliova E, etal., Behav Brain Res. 2009 Dec 28;205(2):377-83. Epub 2009 Jul 16.
Additional References at PubMed
PMID:2319298   PMID:7589457   PMID:11839787   PMID:12493695   PMID:12646584   PMID:12761501   PMID:14550305   PMID:14642832   PMID:15464279   PMID:15489334   PMID:16038798   PMID:16116184  
PMID:16373424   PMID:16691442   PMID:20298813   PMID:20551380   PMID:20689988   PMID:20873803   PMID:21054390   PMID:21188523   PMID:21670307   PMID:21753146   PMID:21998324   PMID:22028908  
PMID:22357632   PMID:22658674   PMID:23106098   PMID:23376485   PMID:23533145   PMID:23979707   PMID:24006456   PMID:25920776   PMID:26392742   PMID:27068509   PMID:27559042   PMID:27573167  
PMID:30463690  


Genomics

Comparative Map Data
Lgals1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27110,485,239 - 110,488,345 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7110,481,392 - 110,488,345 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7112,234,764 - 112,237,858 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07114,458,284 - 114,461,378 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07114,426,881 - 114,429,988 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07120,153,184 - 120,156,290 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7120,153,184 - 120,156,289 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07120,144,875 - 120,147,981 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47116,893,662 - 116,896,768 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17116,927,891 - 116,930,997 (+)NCBI
Celera7106,819,373 - 106,822,479 (+)NCBICelera
Cytogenetic Map7q34NCBI
LGALS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382237,675,636 - 37,679,802 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2237,675,636 - 37,679,802 (+)EnsemblGRCh38hg38GRCh38
GRCh372238,071,643 - 38,075,809 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362236,401,559 - 36,405,755 (+)NCBINCBI36Build 36hg18NCBI36
Build 342236,396,142 - 36,400,307NCBI
Celera2221,873,464 - 21,877,660 (+)NCBICelera
Cytogenetic Map22q13.1NCBI
HuRef2221,038,558 - 21,042,751 (+)NCBIHuRef
CHM1_12238,030,320 - 38,034,516 (+)NCBICHM1_1
T2T-CHM13v2.02238,136,888 - 38,141,054 (+)NCBIT2T-CHM13v2.0
Lgals1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391578,810,925 - 78,814,665 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1578,810,925 - 78,814,665 (+)EnsemblGRCm39 Ensembl
GRCm381578,926,725 - 78,930,465 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1578,926,725 - 78,930,465 (+)EnsemblGRCm38mm10GRCm38
MGSCv371578,757,155 - 78,760,895 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361578,753,980 - 78,757,720 (+)NCBIMGSCv36mm8
MGSCv361579,650,845 - 79,654,585 (+)NCBIMGSCv36mm8
Cytogenetic Map15E1NCBI
cM Map1537.7NCBI
Lgals1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541324,072,086 - 24,075,452 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541324,072,086 - 24,075,452 (+)NCBIChiLan1.0ChiLan1.0
LGALS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan12250,224,324 - 50,228,602 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02218,593,154 - 18,597,432 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12236,426,226 - 36,430,356 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2236,426,228 - 36,430,356 (+)Ensemblpanpan1.1panPan2
LGALS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11026,932,351 - 26,935,580 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1026,932,301 - 26,935,646 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1026,887,006 - 26,890,237 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01027,724,227 - 27,727,457 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1027,724,177 - 27,727,523 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11027,446,500 - 27,449,728 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01027,755,263 - 27,758,492 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01027,932,614 - 27,935,843 (-)NCBIUU_Cfam_GSD_1.0
Lgals1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494510,397,291 - 10,400,438 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364923,407,049 - 3,411,222 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049364923,407,704 - 3,411,197 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LGALS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl510,149,068 - 10,156,023 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1510,149,069 - 10,152,514 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.257,642,321 - 7,645,763 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LGALS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11920,379,144 - 20,383,303 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1920,379,003 - 20,383,464 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045105,440,547 - 105,444,741 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lgals1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475210,219,872 - 10,223,317 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475210,220,115 - 10,223,434 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lgals1
31 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:74
Count of miRNA genes:69
Interacting mature miRNAs:72
Transcripts:ENSRNOT00000013538
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat

Markers in Region
RH124926  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27110,488,239 - 110,488,407 (+)MAPPERmRatBN7.2
Rnor_6.07120,156,185 - 120,156,352NCBIRnor6.0
Rnor_5.07120,147,876 - 120,148,043UniSTSRnor5.0
RGSC_v3.47116,896,663 - 116,896,830UniSTSRGSC3.4
Celera7106,822,374 - 106,822,541UniSTS
Cytogenetic Map7q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 10
Medium 3 43 49 33 19 33 8 11 74 35 31 11 8
Low 8 8 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_019904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC096473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M19036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U40624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000013538   ⟹   ENSRNOP00000013538
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7110,485,202 - 110,488,345 (+)Ensembl
Rnor_6.0 Ensembl7120,153,184 - 120,156,289 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000103260   ⟹   ENSRNOP00000086702
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7110,486,232 - 110,488,345 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115553   ⟹   ENSRNOP00000088674
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7110,486,243 - 110,488,345 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000118467   ⟹   ENSRNOP00000088569
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7110,481,392 - 110,488,345 (+)Ensembl
RefSeq Acc Id: NM_019904   ⟹   NP_063969
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27110,485,239 - 110,488,345 (+)NCBI
Rnor_6.07120,153,184 - 120,156,290 (+)NCBI
Rnor_5.07120,144,875 - 120,147,981 (+)NCBI
RGSC_v3.47116,893,662 - 116,896,768 (+)RGD
Celera7106,819,373 - 106,822,479 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_063969 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40822 (Get FASTA)   NCBI Sequence Viewer  
  AAB88582 (Get FASTA)   NCBI Sequence Viewer  
  AAH58476 (Get FASTA)   NCBI Sequence Viewer  
  EDM15838 (Get FASTA)   NCBI Sequence Viewer  
  P11762 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_063969   ⟸   NM_019904
- UniProtKB: P11762 (UniProtKB/Swiss-Prot),   A6HSN4 (UniProtKB/TrEMBL),   A0A8I6A5K0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000013538   ⟸   ENSRNOT00000013538
RefSeq Acc Id: ENSRNOP00000088674   ⟸   ENSRNOT00000115553
RefSeq Acc Id: ENSRNOP00000086702   ⟸   ENSRNOT00000103260
RefSeq Acc Id: ENSRNOP00000088569   ⟸   ENSRNOT00000118467
Protein Domains
Galectin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P11762-F1-model_v2 AlphaFold P11762 1-135 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69355 AgrOrtholog
BioCyc Gene G2FUF-32790 BioCyc
Ensembl Genes ENSRNOG00000009884 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000013538 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000086702.1 UniProtKB/TrEMBL
  ENSRNOP00000088569.1 UniProtKB/TrEMBL
  ENSRNOP00000088674.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013538 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000103260.1 UniProtKB/TrEMBL
  ENSRNOT00000115553.1 UniProtKB/TrEMBL
  ENSRNOT00000118467.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6920799 IMAGE-MGC_LOAD
InterPro ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galectin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galectin_CRD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:56646 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72847 IMAGE-MGC_LOAD
NCBI Gene 56646 ENTREZGENE
PANTHER GALECTIN-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11346 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Gal-bind_lectin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB LGALS1 RGD
PhenoGen Lgals1 PhenoGen
PROSITE GALECTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Gal-bind_lectin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC204134
UniProt A0A8I6A5K0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A6C2_RAT UniProtKB/TrEMBL
  A0A8I6GGC8_RAT UniProtKB/TrEMBL
  A6HSN4 ENTREZGENE, UniProtKB/TrEMBL
  LEG1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-18 Lgals1  galectin 1  Lgals1  lectin, galactoside-binding, soluble, 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-30 Lgals1  lectin, galactoside-binding, soluble, 1  Lgals1  lectin, galactose binding, soluble 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains hydrophilic protein with approximately equal amounts of alpha helix, beta sheet, beta turn, and random coil 68809
gene_expression expression is decreased 3.0 fold in SHR compared with WKY rats 1357414