Cd44 (CD44 molecule) - Rat Genome Database

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Gene: Cd44 (CD44 molecule) Rattus norvegicus
Analyze
Symbol: Cd44
Name: CD44 molecule
RGD ID: 2307
Description: Enables epidermal growth factor receptor binding activity; phosphoprotein binding activity; and protein kinase binding activity. Involved in several processes, including blood vessel maturation; macrophage fusion; and positive regulation of neutrophil apoptotic process. Located in apical plasma membrane; basolateral plasma membrane; and cell surface. Part of protein-containing complex. Is active in glutamatergic synapse; postsynapse; and presynapse. Biomarker of borna disease and cholestasis. Human ortholog(s) of this gene implicated in breast carcinoma (multiple); carcinoma (multiple); and prostate cancer. Orthologous to human CD44 (CD44 molecule (IN blood group)); PARTICIPATES IN cell-extracellular matrix signaling pathway; INTERACTS WITH (+)-schisandrin B; (S)-colchicine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CD44 antigen; CD44 antigen isoform d6-12; CD44 antigen isoform d6-13; CD44 antigen isoform d6-15; CD44 molecule (Indian blood group); CD44A; cell surface glycoprotein CD44 (hyaluronate binding protein); ECMR-III; extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor; hermes antigen; HUTCH-I; hyaluronate receptor; METAA; MGC124941; PGP-1; PGP-I; phagocytic glycoprotein 1; phagocytic glycoprotein I; RHAMM
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83109,610,824 - 109,699,776 (-)NCBIGRCr8
mRatBN7.2389,155,850 - 89,244,615 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl389,157,058 - 89,244,620 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx392,655,896 - 92,743,295 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03101,254,921 - 101,342,322 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0399,079,238 - 99,166,676 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0392,695,083 - 92,783,820 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl392,696,313 - 92,783,658 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0399,338,248 - 99,426,188 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4388,022,962 - 88,110,352 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1387,919,389 - 88,006,780 (-)NCBI
Celera388,236,830 - 88,324,125 (-)NCBICelera
RH 3.4 Map3656.5RGD
RH 3.4 Map3669.0RGD
Cytogenetic Map3q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-colchicine  (EXP)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-dimethoxyphenol  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-acetamidofluorene  (EXP,IEP)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
2-nitroanisole  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-Amino-2-nitrophenol  (EXP)
4-hydroxynon-2-enal  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (EXP,ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
Actein  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
albuterol  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
allopurinol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
androgen antagonist  (EXP)
antirheumatic drug  (ISO)
Antrocin  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
auramine O  (ISO)
Azaspiracid  (ISO)
bacitracin  (EXP)
bathocuproine disulfonic acid  (ISO)
beclomethasone  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzoates  (ISO)
beryllium sulfate  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
Butylparaben  (EXP)
butyric acid  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
calcium oxalate  (EXP)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carboplatin  (EXP)
carmustine  (ISO)
casticin  (ISO)
chlorogenic acid  (ISO)
chlorpromazine  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
ciprofloxacin  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
coumarin  (ISO)
coumestrol  (ISO)
crizotinib  (ISO)
crocidolite asbestos  (EXP,ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
cytarabine  (ISO)
D-glucose  (ISO)
DDE  (EXP)
decabromodiphenyl ether  (EXP)
deguelin  (ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
diclofenac  (ISO)
Dictamnine  (ISO)
diethylstilbestrol  (ISO)
dimethylarsinous acid  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
diuron  (EXP,ISO)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
enzacamene  (EXP)
enzyme inhibitor  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP)
ethylene glycol  (EXP)
etodolac  (ISO)
etoposide  (ISO)
eugenol  (ISO)
fipronil  (EXP)
fisetin  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
formoterol fumarate  (ISO)
FR900359  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
furan  (EXP)
furfural  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
Gimeracil  (EXP)
glucose  (ISO)
glycidol  (EXP)
glycidyl methacrylate  (ISO)
glycine betaine  (EXP)
glyoxylic acid  (EXP)
glyphosate  (ISO)
graphite  (EXP)
hexestrol  (ISO)
Honokiol  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (ISO)
indometacin  (EXP)
ionomycin  (ISO)
iron dichloride  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
iron(III) nitrilotriacetate  (EXP)
ivermectin  (ISO)
kaempferol  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lamivudine  (ISO)
lapatinib  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP)
linuron  (EXP)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
losartan  (EXP)
lovastatin  (ISO)
LY294002  (ISO)
manganese(II) chloride  (EXP)
melamine  (EXP)
menadione  (ISO)
mercury dibromide  (ISO)
mestranol  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mevalonic acid  (ISO)
microcystin-LR  (ISO)
Muraglitazar  (EXP)
N,N-bis(2-hydroxypropyl)nitrosamine  (EXP)
N-(6-acetamidohexyl)acetamide  (ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nicotine  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
Osajin  (ISO)
oxalic acid  (ISO)
ozone  (EXP,ISO)
panobinostat  (ISO)
para-Cresidine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
phenethyl isothiocyanate  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
poly(I:C)  (ISO)
Pomiferin  (ISO)
proanthocyanidin  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
progesterone  (EXP,ISO)
propiconazole  (ISO)
pyrrolidine dithiocarbamate  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
reparixin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
stattic  (ISO)
succimer  (ISO)
sulfaphenazole  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (EXP)
tamibarotene  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
theaflavin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
thymoquinone  (ISO)
titanium dioxide  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
trifluoperazine  (ISO)
trimethyltin  (ISO)
triphenyl phosphate  (ISO)
triphenylstannane  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
ubiquinone-0  (ISO)
uracil  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
verapamil  (ISO)
vincaleukoblastine  (EXP)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zidovudine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blood vessel maturation  (IEP)
branching involved in prostate gland morphogenesis  (ISO)
branching involved in ureteric bud morphogenesis  (ISO)
cartilage development  (IEA,ISO)
cell adhesion  (IBA,IEA,IMP,ISO,NAS)
cell migration  (IEA,IMP,ISO)
cellular response to fibroblast growth factor stimulus  (IEA,ISO)
cytokine-mediated signaling pathway  (IEA)
hyaluronan catabolic process  (IEA,ISO)
inflammatory response  (IBA)
macrophage fusion  (IMP)
monocyte aggregation  (IEA,ISO)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of CD4-positive, alpha-beta T cell proliferation  (ISO)
negative regulation of DNA damage response, signal transduction by p53 class mediator  (IEA,ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (IEA,ISO)
negative regulation of mature B cell apoptotic process  (ISO)
negative regulation of regulatory T cell differentiation  (ISO)
neuron projection development  (IMP)
positive regulation of ERK1 and ERK2 cascade  (IBA,IEA,ISO)
positive regulation of gene expression  (ISO)
positive regulation of heterotypic cell-cell adhesion  (IEA,ISO)
positive regulation of kinase activity  (ISO)
positive regulation of monocyte aggregation  (IEA,ISO)
positive regulation of neutrophil apoptotic process  (IMP)
postsynapse organization  (IDA,IMP)
receptor-mediated endocytosis  (ISO)
regulation of cell growth  (IDA)
regulation of lamellipodium morphogenesis  (IEA,ISO,ISS)
regulation of modification of postsynaptic structure  (EXP,IDA,IMP)
response to nutrient levels  (IEP)
response to vitamin A  (IEP)
T cell activation  (IEA,ISO)
Wnt signaling pathway  (ISO)
wound healing involved in inflammatory response  (ISO)
wound healing, spreading of cells  (IEA,ISO,ISS)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Short-term effects of adolescent methylphenidate exposure on brain striatal gene expression and sexual/endocrine parameters in male rats. Adriani W, etal., Ann N Y Acad Sci. 2006 Aug;1074:52-73.
2. Diagnostic utility of CD44 standard, CD44v6, and CD44v3-10 expression in adenocarcinomas presenting in serous fluids. Afify A, etal., Appl Immunohistochem Mol Morphol. 2007 Dec;15(4):446-50.
3. Expression of hyaluronic acid and its receptors, CD44s and CD44v6, in normal, hyperplastic, and neoplastic endometrium. Afify AM, etal., Ann Diagn Pathol. 2005 Dec;9(6):312-8.
4. Hyaluronan expression following middle cerebral artery occlusion in the rat. Al Qteishat A, etal., Neuroreport. 2006 Jul 31;17(11):1111-4.
5. Wild-Type Isocitrate Dehydrogenase 1 Over-Expression is Related to Cancer Stem Cells Survival in Lung Adenocarcinoma. Al-Amodi HSAB, etal., Cancer Invest. 2018 Mar 16;36(3):185-189. doi: 10.1080/07357907.2018.1445262. Epub 2018 Mar 14.
6. Participation in normal immune responses of a metastasis-inducing splice variant of CD44. Arch R, etal., Science 1992 Jul 31;257(5070):682-5.
7. [Progress in the evaluation of lymphatic involvement in cancer of the rectum: endoscopic rectal lymphoscintigraphy] Arnaud JP, etal., Minerva Chir 1990 Feb;45(3-4):137-40.
8. Expression of CD44 isoforms in infiltrating lobular carcinoma of the breast. Berner HS and Nesland JM, Breast Cancer Res Treat. 2001 Jan;65(1):23-9.
9. Physical association of the cytoplasmic domain of CD2 with the tyrosine kinases p56lck and p59fyn. Carmo AM, etal., Eur J Immunol. 1993 Sep;23(9):2196-201.
10. Fibrin biopolymer as scaffold candidate to treat bone defects in rats. Cassaro CV, etal., J Venom Anim Toxins Incl Trop Dis. 2019 Nov 4;25:e20190027. doi: 10.1590/1678-9199-JVATITD-2019-0027. eCollection 2019.
11. Increased hyaluronan and CD44 expressions in intravenous leiomyomatosis. Chen MJ, etal., Acta Obstet Gynecol Scand. 2005 Apr;84(4):322-8.
12. The intracellular domain of CD44 promotes the fusion of macrophages. Cui W, etal., Blood. 2006 Jan 15;107(2):796-805. Epub 2005 Sep 29.
13. Dynamics of hyaluronan, CD44, and inflammatory cells in the rat kidney after ischemia/reperfusion injury. Decleves AE, etal., Int J Mol Med. 2006 Jul;18(1):83-94.
14. Abnormal CD44 activation of hepatocytes with nonalcoholic fatty accumulation in rat hepatocarcinogenesis. Fang M, etal., World J Gastrointest Oncol. 2020 Jan 15;12(1):66-76. doi: 10.4251/wjgo.v12.i1.66.
15. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
16. Expression and prognostic value Of CD44 isoforms in nephroblastoma (Wilms tumor). Ghanem MA, etal., J Urol. 2002 Aug;168(2):681-6.
17. A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells. Gunthert U, etal., Cell 1991 Apr 5;65(1):13-24.
18. Cellular adhesion molecules in rat adjuvant arthritis. Halloran MM, etal., Arthritis Rheum. 1996 May;39(5):810-9.
19. Parallel up-regulation of FGF-2 and hyaluronan during development of cardiac hypertrophy in rat. Hellman U, etal., Cell Tissue Res. 2008 Jan 15;.
20. Expression of the CD44 receptor in the blood vessel system: an experimental study in rat. Hellstrom M, etal., Cells Tissues Organs. 2005;179(3):102-8.
21. A role for CD44 in an antigen-induced murine model of pulmonary eosinophilia. Katoh S, etal., J Clin Invest. 2003 May;111(10):1563-70.
22. Modeling of hyperoxaluric calcium oxalate nephrolithiasis: experimental induction of hyperoxaluria by hydroxy-L-proline. Khan SR, etal., Kidney Int. 2006 Sep;70(5):914-23. Epub 2006 Jul 19.
23. Integrin alpha(5) interacts with EGFR, is necessary for FcvarepsilonRI signaling and is necessary for allergic inflammation in relation with angiogenesis. Kim Y, etal., Mol Immunol. 2011 Apr;48(8):1035-45. Epub 2011 Feb 23.
24. Downregulation of BRG-1 repressed expression of CD44s in cervical neuroendocrine carcinoma and adenocarcinoma. Kuo KT, etal., Mod Pathol. 2006 Dec;19(12):1570-7. Epub 2006 Sep 22.
25. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
26. Ai zheng = Aizheng = Chinese journal of cancer Lian ZQ, etal., Ai Zheng. 2006 Oct;25(10):1291-5.
27. Prognostic role of CD44 cell adhesion molecule expression in primary and metastatic renal cell carcinoma: a clinicopathologic study of 125 cases. Lim SD, etal., Virchows Arch. 2008 Jan;452(1):49-55. Epub 2007 Nov 20.
28. Expression and significance of CD44s, CD44v6, and nm23 mRNA in human cancer. Liu YJ, etal., World J Gastroenterol. 2005 Nov 14;11(42):6601-6.
29. Expression and correlation of CD44v6, vascular endothelial growth factor, matrix metalloproteinase-2, and matrix metalloproteinase-9 in Krukenberg tumor. Lou G, etal., World J Gastroenterol. 2005 Aug 28;11(32):5032-6.
30. Expression and prognostic value of CD44 isoforms in transitional cell carcinoma of renal pelvis and ureter. Masuda M, etal., J Urol. 1999 Mar;161(3):805-8; discussion 808-9.
31. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
32. Expression of CD44 adhesion molecule in rat testis with ischemia/reperfusion injury. Moon C, etal., J Vet Med Sci. 2006 Jul;68(7):761-4.
33. The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44. Morrison H, etal., Genes Dev. 2001 Apr 15;15(8):968-80.
34. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
35. In vivo evidence for the role of CD44s in promoting breast cancer metastasis to the liver. Ouhtit A, etal., Am J Pathol. 2007 Dec;171(6):2033-9. Epub 2007 Nov 8.
36. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
37. Erbin regulates mitogen-activated protein (MAP) kinase activation and MAP kinase-dependent interactions between Merlin and adherens junction protein complexes in Schwann cells. Rangwala R, etal., J Biol Chem. 2005 Mar 25;280(12):11790-7. Epub 2005 Jan 19.
38. GOA pipeline RGD automated data pipeline
39. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
40. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
41. A novel biological function for CD44 in axon growth of retinal ganglion cells identified by a bioinformatics approach. Ries A, etal., J Neurochem. 2007 Nov;103(4):1491-505. Epub 2007 Aug 30.
42. CD44: a novel synaptic cell adhesion molecule regulating structural and functional plasticity of dendritic spines. Roszkowska M, etal., Mol Biol Cell. 2016 Dec 15;27(25):4055-4066. doi: 10.1091/mbc.E16-06-0423. Epub 2016 Oct 19.
43. Effect of vitamin A on the CD44 expression in the small intestine of rats with obstructive jaundice. Sen M, etal., Eur Surg Res. 2006;38(3):347-52. Epub 2006 Jun 23.
44. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
45. [Clinical evaluation of BTAstat, NMP22, HA, survivin, CD44v6, vEGF and VUC in bladder cancer diagnosis] Sun Y, etal., Zhonghua Yi Xue Za Zhi. 2005 Sep 14;85(35):2507-12.
46. Colocalization of intracellular osteopontin with CD44 is associated with migration, cell fusion, and resorption in osteoclasts. Suzuki K, etal., J Bone Miner Res 2002 Aug;17(8):1486-97.
47. CD44-mediated neutrophil apoptosis in the rat. Takazoe K, etal., Kidney Int. 2000 Nov;58(5):1920-30.
48. Prognostic significance of CD44, platelet-derived growth factor receptor alpha, and cyclooxygenase 2 expression in renal cell carcinoma. Tawfik OW, etal., Arch Pathol Lab Med. 2007 Feb;131(2):261-7.
49. Metallothioneins and zinc dysregulation contribute to neurodevelopmental damage in a model of perinatal viral infection. Williams BL, etal., Brain Pathol. 2006 Jan;16(1):1-14.
50. CD44 and PTGS2 methylation are independent prognostic markers for biochemical recurrence among prostate cancer patients with clinically localized disease. Woodson K, etal., Epigenetics. 2006 Oct-Dec;1(4):183-6.
51. Correlation of CD44v5 expression with invasiveness and prognosis in renal cell carcinoma. Wu ST, etal., J Formos Med Assoc. 2003 Apr;102(4):229-33.
52. Analyses of Bcl-2, Survivin, and CD44v6 expressions and human papillomavirus infection in cervical carcinomas. Yaqin M, etal., Scand J Infect Dis. 2007;39(5):441-8.
53. Glycoprotein CD44 expression in normal, hyperplasic and neoplastic endometrium. An immunohistochemical study including correlations with p53, steroid receptor status and proliferative indices (PCNA, MIB1). Zagorianakou N, etal., Eur J Gynaecol Oncol. 2003;24(6):500-4.
54. The role of the hyaluronan receptor CD44 in mesenchymal stem cell migration in the extracellular matrix. Zhu H, etal., Stem Cells. 2006 Apr;24(4):928-35. Epub 2005 Nov 23.
Additional References at PubMed
PMID:1469058   PMID:7528188   PMID:7538697   PMID:7584142   PMID:8043862   PMID:8769481   PMID:9133426   PMID:9324354   PMID:9374396   PMID:9472040   PMID:9692903   PMID:9847236  
PMID:10027409   PMID:10072077   PMID:10704459   PMID:10848813   PMID:10926769   PMID:10943842   PMID:11084024   PMID:11935029   PMID:11944887   PMID:12061795   PMID:12579564   PMID:12839939  
PMID:14609575   PMID:14764662   PMID:15100360   PMID:15212938   PMID:15294943   PMID:15477346   PMID:15531362   PMID:15624701   PMID:15691832   PMID:15701601   PMID:15728238   PMID:15843532  
PMID:16177108   PMID:16203996   PMID:16301745   PMID:16580085   PMID:16809613   PMID:16973387   PMID:17045821   PMID:17065554   PMID:17082577   PMID:17170110   PMID:17324121   PMID:17716972  
PMID:18056708   PMID:18085615   PMID:18450824   PMID:18556418   PMID:18638458   PMID:18694596   PMID:18958875   PMID:19008373   PMID:19047049   PMID:19056892   PMID:19199708   PMID:19208744  
PMID:19222954   PMID:19299737   PMID:19385056   PMID:19439532   PMID:19577615   PMID:19703720   PMID:19723499   PMID:19783662   PMID:19794968   PMID:19934022   PMID:20056122   PMID:20458337  
PMID:20470282   PMID:20522558   PMID:20711497   PMID:20962267   PMID:21423176   PMID:21460847   PMID:21508411   PMID:21708977   PMID:22072979   PMID:22470101   PMID:22692550   PMID:22726066  
PMID:23241663   PMID:23280959   PMID:23533145   PMID:23884413   PMID:25065622   PMID:25253654   PMID:25300795   PMID:25733665   PMID:26597578   PMID:26996509   PMID:27085217   PMID:27163367  
PMID:28871329   PMID:29175954   PMID:29589805   PMID:30951363   PMID:32223952   PMID:33450132   PMID:36646166   PMID:37751106   PMID:37876353   PMID:37888730  


Genomics

Comparative Map Data
Cd44
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83109,610,824 - 109,699,776 (-)NCBIGRCr8
mRatBN7.2389,155,850 - 89,244,615 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl389,157,058 - 89,244,620 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx392,655,896 - 92,743,295 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03101,254,921 - 101,342,322 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0399,079,238 - 99,166,676 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0392,695,083 - 92,783,820 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl392,696,313 - 92,783,658 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0399,338,248 - 99,426,188 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4388,022,962 - 88,110,352 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1387,919,389 - 88,006,780 (-)NCBI
Celera388,236,830 - 88,324,125 (-)NCBICelera
RH 3.4 Map3656.5RGD
RH 3.4 Map3669.0RGD
Cytogenetic Map3q32NCBI
CD44
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381135,139,171 - 35,232,402 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1135,138,882 - 35,232,402 (+)EnsemblGRCh38hg38GRCh38
GRCh371135,160,718 - 35,253,949 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361135,116,993 - 35,210,525 (+)NCBINCBI36Build 36hg18NCBI36
Build 341135,116,992 - 35,210,524NCBI
Celera1135,307,730 - 35,401,272 (+)NCBICelera
Cytogenetic Map11p13NCBI
HuRef1134,858,894 - 34,952,423 (+)NCBIHuRef
CHM1_11135,158,655 - 35,252,358 (+)NCBICHM1_1
T2T-CHM13v2.01135,277,234 - 35,370,499 (+)NCBIT2T-CHM13v2.0
Cd44
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392102,641,486 - 102,732,014 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2102,641,486 - 102,732,010 (-)EnsemblGRCm39 Ensembl
GRCm382102,811,141 - 102,901,669 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2102,811,141 - 102,901,665 (-)EnsemblGRCm38mm10GRCm38
MGSCv372102,651,298 - 102,741,822 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362102,611,980 - 102,702,504 (-)NCBIMGSCv36mm8
Celera2104,054,974 - 104,145,651 (-)NCBICelera
Cytogenetic Map2E2NCBI
cM Map254.13NCBI
Cd44
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542211,106,061 - 11,189,951 (-)NCBIChiLan1.0ChiLan1.0
CD44
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2937,358,331 - 37,517,759 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11137,363,105 - 37,511,625 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01135,110,732 - 35,258,238 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11134,985,634 - 35,132,900 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1134,985,634 - 35,079,009 (+)Ensemblpanpan1.1panPan2
CD44
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11832,735,493 - 32,826,483 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1832,737,907 - 32,827,107 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1832,344,254 - 32,432,780 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01833,345,940 - 33,436,801 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1833,345,949 - 33,437,425 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11832,909,118 - 32,997,479 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01832,494,751 - 32,582,918 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01833,135,283 - 33,223,633 (-)NCBIUU_Cfam_GSD_1.0
Cd44
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494729,824,204 - 29,908,520 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365332,949,026 - 3,033,166 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD44
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl225,788,703 - 25,884,153 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1225,788,699 - 25,884,209 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2228,156,390 - 28,249,949 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CD44
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1130,039,854 - 30,132,646 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl130,039,749 - 30,132,416 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038127,154,654 - 127,246,994 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cd44
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476711,938,028 - 12,025,069 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476711,938,452 - 12,024,970 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cd44
383 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1272
Count of miRNA genes:245
Interacting mature miRNAs:300
Transcripts:ENSRNOT00000008760, ENSRNOT00000009000, ENSRNOT00000009073
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35318469289878207Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)384091273129091273Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)380800231114297550Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35378111291609953Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat

Markers in Region
PMC111028P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2389,158,688 - 89,158,782 (+)MAPPERmRatBN7.2
Rnor_6.0392,697,922 - 92,698,015NCBIRnor6.0
Rnor_5.0399,341,087 - 99,341,180UniSTSRnor5.0
RGSC_v3.4388,024,592 - 88,024,685UniSTSRGSC3.4
Celera388,238,460 - 88,238,553UniSTS
Cytogenetic Map3q31UniSTS
RH142186  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2389,157,588 - 89,157,763 (+)MAPPERmRatBN7.2
Rnor_6.0392,696,822 - 92,696,996NCBIRnor6.0
Rnor_5.0399,339,987 - 99,340,161UniSTSRnor5.0
RGSC_v3.4388,023,492 - 88,023,666UniSTSRGSC3.4
Celera388,237,360 - 88,237,534UniSTS
RH 3.4 Map3669.0UniSTS
Cytogenetic Map3q31UniSTS
RH94478  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2389,157,121 - 89,157,221 (+)MAPPERmRatBN7.2
Rnor_6.0392,696,355 - 92,696,454NCBIRnor6.0
Rnor_5.0399,339,520 - 99,339,619UniSTSRnor5.0
RGSC_v3.4388,023,025 - 88,023,124UniSTSRGSC3.4
Celera388,236,893 - 88,236,992UniSTS
Cytogenetic Map3q31UniSTS
RH134771  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2389,157,192 - 89,157,405 (+)MAPPERmRatBN7.2
Rnor_6.0392,696,426 - 92,696,638NCBIRnor6.0
Rnor_5.0399,339,591 - 99,339,803UniSTSRnor5.0
RGSC_v3.4388,023,096 - 88,023,308UniSTSRGSC3.4
Celera388,236,964 - 88,237,176UniSTS
RH 3.4 Map3669.0UniSTS
Cytogenetic Map3q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC109112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF014365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF065147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF295360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF295361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF295362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF295363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC085703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC107949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC127485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU366999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP901010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP901011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP901012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP901013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M61874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M61875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S41274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U46957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U52179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U96138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000008760   ⟹   ENSRNOP00000008760
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl389,157,080 - 89,244,456 (-)Ensembl
Rnor_6.0 Ensembl392,697,833 - 92,749,121 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000009000   ⟹   ENSRNOP00000009000
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl389,157,080 - 89,244,456 (-)Ensembl
Rnor_6.0 Ensembl392,696,313 - 92,783,658 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000009073   ⟹   ENSRNOP00000009073
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl389,157,080 - 89,244,456 (-)Ensembl
Rnor_6.0 Ensembl392,697,571 - 92,783,569 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102139   ⟹   ENSRNOP00000097897
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl389,157,080 - 89,210,186 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107007   ⟹   ENSRNOP00000096654
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl389,157,058 - 89,244,620 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109066   ⟹   ENSRNOP00000078366
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl389,157,080 - 89,244,456 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111131   ⟹   ENSRNOP00000090715
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl389,157,080 - 89,244,456 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111172   ⟹   ENSRNOP00000080825
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl389,157,080 - 89,244,456 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114481   ⟹   ENSRNOP00000090045
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl389,157,080 - 89,244,456 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116432   ⟹   ENSRNOP00000092325
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl389,157,080 - 89,244,456 (-)Ensembl
RefSeq Acc Id: NM_012924   ⟹   NP_037056
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83109,612,033 - 109,699,424 (-)NCBI
mRatBN7.2389,157,059 - 89,244,456 (-)NCBI
Rnor_6.0392,696,292 - 92,783,658 (-)NCBI
Rnor_5.0399,338,248 - 99,426,188 (-)NCBI
RGSC_v3.4388,022,962 - 88,110,352 (-)RGD
Celera388,236,830 - 88,324,125 (-)RGD
Sequence:
RefSeq Acc Id: XM_006234627   ⟹   XP_006234689
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83109,610,824 - 109,699,550 (-)NCBI
mRatBN7.2389,155,850 - 89,244,573 (-)NCBI
Rnor_6.0392,695,083 - 92,783,820 (-)NCBI
Rnor_5.0399,338,248 - 99,426,188 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006234629   ⟹   XP_006234691
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83109,610,824 - 109,699,641 (-)NCBI
mRatBN7.2389,155,850 - 89,244,560 (-)NCBI
Rnor_6.0392,695,083 - 92,783,816 (-)NCBI
Rnor_5.0399,338,248 - 99,426,188 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006234631   ⟹   XP_006234693
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83109,610,824 - 109,699,776 (-)NCBI
mRatBN7.2389,155,850 - 89,244,531 (-)NCBI
Rnor_6.0392,695,083 - 92,783,800 (-)NCBI
Rnor_5.0399,338,248 - 99,426,188 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008762058   ⟹   XP_008760280
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83109,610,824 - 109,699,550 (-)NCBI
mRatBN7.2389,155,850 - 89,244,615 (-)NCBI
Rnor_6.0392,695,083 - 92,783,810 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039104367   ⟹   XP_038960295
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83109,610,824 - 109,699,550 (-)NCBI
mRatBN7.2389,155,850 - 89,244,568 (-)NCBI
RefSeq Acc Id: XM_039104369   ⟹   XP_038960297
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83109,610,824 - 109,699,550 (-)NCBI
mRatBN7.2389,155,850 - 89,244,524 (-)NCBI
RefSeq Acc Id: XM_063283151   ⟹   XP_063139221
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83109,610,824 - 109,699,550 (-)NCBI
RefSeq Acc Id: XM_063283152   ⟹   XP_063139222
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83109,610,824 - 109,699,550 (-)NCBI
RefSeq Acc Id: XM_063283153   ⟹   XP_063139223
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83109,610,824 - 109,699,550 (-)NCBI
RefSeq Acc Id: XM_063283155   ⟹   XP_063139225
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83109,610,824 - 109,699,550 (-)NCBI
RefSeq Acc Id: XM_063283156   ⟹   XP_063139226
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83109,610,824 - 109,699,550 (-)NCBI
RefSeq Acc Id: XM_063283157   ⟹   XP_063139227
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83109,610,824 - 109,699,550 (-)NCBI
Protein Sequences
Protein RefSeqs NP_037056 (Get FASTA)   NCBI Sequence Viewer  
  XP_006234689 (Get FASTA)   NCBI Sequence Viewer  
  XP_006234691 (Get FASTA)   NCBI Sequence Viewer  
  XP_006234693 (Get FASTA)   NCBI Sequence Viewer  
  XP_008760280 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960295 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960297 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139221 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139222 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139223 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139225 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139226 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139227 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA53532 (Get FASTA)   NCBI Sequence Viewer  
  AAA53534 (Get FASTA)   NCBI Sequence Viewer  
  AAA92920 (Get FASTA)   NCBI Sequence Viewer  
  AAA97915 (Get FASTA)   NCBI Sequence Viewer  
  AAB54002 (Get FASTA)   NCBI Sequence Viewer  
  AAB67798 (Get FASTA)   NCBI Sequence Viewer  
  AAC17117 (Get FASTA)   NCBI Sequence Viewer  
  AAG31599 (Get FASTA)   NCBI Sequence Viewer  
  AAG31600 (Get FASTA)   NCBI Sequence Viewer  
  AAG31601 (Get FASTA)   NCBI Sequence Viewer  
  AAG31602 (Get FASTA)   NCBI Sequence Viewer  
  AAH61531 (Get FASTA)   NCBI Sequence Viewer  
  AAH85703 (Get FASTA)   NCBI Sequence Viewer  
  AAI07950 (Get FASTA)   NCBI Sequence Viewer  
  AAI27486 (Get FASTA)   NCBI Sequence Viewer  
  ACA62739 (Get FASTA)   NCBI Sequence Viewer  
  ALB05590 (Get FASTA)   NCBI Sequence Viewer  
  ALB05591 (Get FASTA)   NCBI Sequence Viewer  
  ALB05592 (Get FASTA)   NCBI Sequence Viewer  
  ALB05593 (Get FASTA)   NCBI Sequence Viewer  
  EDL79648 (Get FASTA)   NCBI Sequence Viewer  
  EDL79649 (Get FASTA)   NCBI Sequence Viewer  
  EDL79650 (Get FASTA)   NCBI Sequence Viewer  
  EDL79651 (Get FASTA)   NCBI Sequence Viewer  
  EDL79652 (Get FASTA)   NCBI Sequence Viewer  
  EDL79653 (Get FASTA)   NCBI Sequence Viewer  
  EDL79654 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000008760
  ENSRNOP00000008760.7
  ENSRNOP00000009000
  ENSRNOP00000009000.3
  ENSRNOP00000009073.7
  ENSRNOP00000078366.1
  ENSRNOP00000080825
  ENSRNOP00000080825.1
  ENSRNOP00000090045.1
  ENSRNOP00000090715
  ENSRNOP00000090715.1
  ENSRNOP00000092325.1
  ENSRNOP00000096654
  ENSRNOP00000096654.1
  ENSRNOP00000097897.1
GenBank Protein P26051 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037056   ⟸   NM_012924
- Peptide Label: precursor
- UniProtKB: F1LSA1 (UniProtKB/TrEMBL),   A6HNQ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234689   ⟸   XM_006234627
- Peptide Label: isoform X1
- UniProtKB: D3ZGF1 (UniProtKB/TrEMBL),   A6HNQ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234691   ⟸   XM_006234629
- Peptide Label: isoform X6
- UniProtKB: A0A8I5ZRQ4 (UniProtKB/TrEMBL),   A6HNQ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234693   ⟸   XM_006234631
- Peptide Label: isoform X12
- UniProtKB: O70509 (UniProtKB/TrEMBL),   D4A7E6 (UniProtKB/TrEMBL),   A6HNP7 (UniProtKB/TrEMBL),   A0JPL1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760280   ⟸   XM_008762058
- Peptide Label: isoform X9
- UniProtKB: A0A8I6APP8 (UniProtKB/TrEMBL),   A6HNQ1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008760   ⟸   ENSRNOT00000008760
Ensembl Acc Id: ENSRNOP00000009000   ⟸   ENSRNOT00000009000
Ensembl Acc Id: ENSRNOP00000009073   ⟸   ENSRNOT00000009073
RefSeq Acc Id: XP_038960295   ⟸   XM_039104367
- Peptide Label: isoform X3
- UniProtKB: A0A8I6GJ35 (UniProtKB/TrEMBL),   A0A8I5ZKQ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960297   ⟸   XM_039104369
- Peptide Label: isoform X10
- UniProtKB: A6HNP8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000096654   ⟸   ENSRNOT00000107007
Ensembl Acc Id: ENSRNOP00000080825   ⟸   ENSRNOT00000111172
Ensembl Acc Id: ENSRNOP00000090715   ⟸   ENSRNOT00000111131
Ensembl Acc Id: ENSRNOP00000097897   ⟸   ENSRNOT00000102139
Ensembl Acc Id: ENSRNOP00000090045   ⟸   ENSRNOT00000114481
Ensembl Acc Id: ENSRNOP00000092325   ⟸   ENSRNOT00000116432
Ensembl Acc Id: ENSRNOP00000078366   ⟸   ENSRNOT00000109066
RefSeq Acc Id: XP_063139227   ⟸   XM_063283157
- Peptide Label: isoform X11
- UniProtKB: A6HNP8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139225   ⟸   XM_063283155
- Peptide Label: isoform X7
- UniProtKB: A6HNQ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139223   ⟸   XM_063283153
- Peptide Label: isoform X5
- UniProtKB: A6HNQ2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139226   ⟸   XM_063283156
- Peptide Label: isoform X8
- UniProtKB: A6HNQ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139222   ⟸   XM_063283152
- Peptide Label: isoform X4
- UniProtKB: A6HNQ2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139221   ⟸   XM_063283151
- Peptide Label: isoform X2
- UniProtKB: A6HNQ2 (UniProtKB/TrEMBL)
Protein Domains
Link

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P26051-F1-model_v2 AlphaFold P26051 1-503 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692254
Promoter ID:EPDNEW_R2774
Type:multiple initiation site
Name:Cd44_1
Description:CD44 molecule
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0392,783,658 - 92,783,718EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2307 AgrOrtholog
BioCyc Gene G2FUF-48591 BioCyc
Ensembl Genes ENSRNOG00000006094 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008760 ENTREZGENE
  ENSRNOT00000008760.8 UniProtKB/TrEMBL
  ENSRNOT00000009000 ENTREZGENE
  ENSRNOT00000009000.8 UniProtKB/TrEMBL
  ENSRNOT00000009073.8 UniProtKB/TrEMBL
  ENSRNOT00000102139.1 UniProtKB/TrEMBL
  ENSRNOT00000107007 ENTREZGENE
  ENSRNOT00000107007.1 UniProtKB/TrEMBL
  ENSRNOT00000109066.1 UniProtKB/TrEMBL
  ENSRNOT00000111131 ENTREZGENE
  ENSRNOT00000111131.1 UniProtKB/TrEMBL
  ENSRNOT00000111172 ENTREZGENE
  ENSRNOT00000111172.1 UniProtKB/TrEMBL
  ENSRNOT00000114481.1 UniProtKB/TrEMBL
  ENSRNOT00000116432.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C-type_lectin-like/link_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CD44_antigen UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CD44_antigen-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTDL_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Link_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25406 UniProtKB/TrEMBL
NCBI Gene 25406 ENTREZGENE
PANTHER PTHR10225 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10225:SF6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Xlink UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cd44 PhenoGen
PRINTS CD44 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LINKMODULE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LINK_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LINK_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006094 RatGTEx
SMART LINK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56436 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0K2JZ63_RAT UniProtKB/TrEMBL
  A0A0K2JZI6_RAT UniProtKB/TrEMBL
  A0A0K2JZP0_RAT UniProtKB/TrEMBL
  A0A0K2JZT3_RAT UniProtKB/TrEMBL
  A0A8I5ZKQ4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZRQ4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ADP5_RAT UniProtKB/TrEMBL
  A0A8I6AHM1_RAT UniProtKB/TrEMBL
  A0A8I6APP8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GJ35 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GMQ6_RAT UniProtKB/TrEMBL
  A0A8J8XKD3_RAT UniProtKB/TrEMBL
  A0JPL1 ENTREZGENE, UniProtKB/TrEMBL
  A6HNP7 ENTREZGENE
  A6HNP8 ENTREZGENE, UniProtKB/TrEMBL
  A6HNP9_RAT UniProtKB/TrEMBL
  A6HNQ0 ENTREZGENE, UniProtKB/TrEMBL
  A6HNQ1 ENTREZGENE, UniProtKB/TrEMBL
  A6HNQ2 ENTREZGENE, UniProtKB/TrEMBL
  A6HNQ3 ENTREZGENE, UniProtKB/TrEMBL
  CD44_RAT UniProtKB/Swiss-Prot
  D3ZGF1 ENTREZGENE, UniProtKB/TrEMBL
  D4A7E6 ENTREZGENE
  F1LSA1 ENTREZGENE, UniProtKB/TrEMBL
  O08779_RAT UniProtKB/TrEMBL
  O70509 ENTREZGENE, UniProtKB/TrEMBL
  P26051 ENTREZGENE
UniProt Secondary A6HNP7 UniProtKB/TrEMBL
  D4A7E6 UniProtKB/TrEMBL
  Q99021 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-02-02 Cd44  CD44 molecule  Cd44  CD44 molecule (Indian blood group)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-02-02 Cd44  CD44 molecule (Indian blood group)  Cd44  Cd44 molecule  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-29 Cd44  Cd44 molecule  Cd44  CD44 antigen  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Cd44  CD44 antigen    Cell surface glycoprotein CD44 (hyaluronate binding protein)  Name updated 625702 APPROVED
2002-06-10 Cd44  Cell surface glycoprotein CD44 (hyaluronate binding protein)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function adhesion molecule 634718
gene_process has a role in metastatic behavior of cells 634718
gene_process has a role in metastatic behavior of cells 1299831
gene_process has a role in migration, cell fusion, and resorption in osteoclasts 634719
gene_process has a role in migration, cell fusion, and resorption in osteoclasts 730240