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Gene: FYN (FYN proto-oncogene, Src family tyrosine kinase) Homo sapiens
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Symbol: FYN
Name: FYN proto-oncogene, Src family tyrosine kinase
Description: Exhibits several functions, including disordered domain specific binding activity; identical protein binding activity; and signaling receptor binding activity. Involved in several processes, including T cell receptor signaling pathway; cellular response to amyloid-beta; and peptidyl-tyrosine phosphorylation. Localizes to the cytosol; endosome; and plasma membrane. Colocalizes with the membrane raft. Implicated in Alzheimer's disease and schizophrenia. Biomarker of Alzheimer's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: c-syn protooncogene; FYN oncogene related to SRC, FGR, YES; MGC45350; OKT3-induced calcium influx regulator; p59-FYN; protein-tyrosine kinase fyn; proto-oncogene c-Fyn; proto-oncogene Syn; proto-oncogene tyrosine-protein kinase fyn; SLK; src-like kinase; src/yes-related novel; SYN; tyrosine kinase p59fyn(T); tyrosine-protein kinase Fyn
Orthologs:
Mus musculus (house mouse) : Fyn (Fyn proto-oncogene)  MGI  Alliance
Rattus norvegicus (Norway rat) : Fyn (FYN proto-oncogene, Src family tyrosine kinase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fyn (FYN proto-oncogene, Src family tyrosine kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : FYN (FYN proto-oncogene, Src family tyrosine kinase)
Canis lupus familiaris (dog) : FYN (FYN proto-oncogene, Src family tyrosine kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fyn (FYN proto-oncogene, Src family tyrosine kinase)
Sus scrofa (pig) : FYN (FYN proto-oncogene, Src family tyrosine kinase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386111,660,332 - 111,873,452 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh376111,981,535 - 112,194,655 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366112,089,178 - 112,301,320 (-)NCBINCBI36hg18NCBI36
Build 346112,089,179 - 112,186,978NCBI
Celera6112,729,071 - 112,941,209 (-)NCBI
Cytogenetic Map6q21NCBI
HuRef6109,554,123 - 109,767,060 (-)NCBIHuRef
CHM1_16112,244,349 - 112,457,405 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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Expression


Sequence

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Nomenclature History
 
More on FYN
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731929
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.