Yes1 (YES proto-oncogene 1, Src family tyrosine kinase)

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Gene: Yes1 (YES proto-oncogene 1, Src family tyrosine kinase) Rattus norvegicus

Analyze

Symbol:

Yes1

Name:

YES proto-oncogene 1, Src family tyrosine kinase

RGD ID:

3977

Description:

Enables epidermal growth factor receptor binding activity and protein tyrosine kinase activity. Predicted to be involved in cell differentiation; innate immune response; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within several processes, including cellular response to platelet-derived growth factor stimulus; cellular response to retinoic acid; and positive regulation of nitrogen compound metabolic process. Is active in glutamatergic synapse and postsynaptic specialization, intracellular component. Orthologous to human YES1 (YES proto-oncogene 1, Src family tyrosine kinase); PARTICIPATES IN eicosanoid signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; glypican signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1; ammonium chloride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

c-Yes; LOC363300; MGC94936; p60c-yes; p61-Yes; tyrosine-protein kinase Yes; Yamagichi sarcoma viral (v-yes-1) oncogene homolog 1; Yamaguchi sarcoma viral (v-yes) oncogene homolog; Yamaguchi sarcoma viral (v-yes) oncogene homolog 1; Yamaguchi sarcoma viral oncogene homolog 1; Yes

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	9	113,200,256 - 113,275,942 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	113,200,256 - 113,299,837 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	121,684,273 - 121,760,004 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	126,813,413 - 126,889,144 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	125,159,312 - 125,235,046 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	121,802,471 - 121,918,906 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	121,802,673 - 121,902,678 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	121,252,194 - 121,327,422 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	112,516,831 - 112,564,072 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	9	110,304,110 - 110,380,060 (+)	NCBI		Celera
Cytogenetic Map	9	q38	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

COVID-19 (ISO)

double outlet right ventricle (ISO)

genetic disease (ISO)

Myocardial Reperfusion Injury (ISO)

Neurodevelopmental Disorders (ISO)

Prenatal Injuries (ISO)

Vascular Malformations (ISO)

ventricular septal defect (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

(S)-nicotine (ISO)

1,2-dimethylhydrazine (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-tribromophenol (ISO)

2-deoxy-D-glucose (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxynon-2-enal (ISO)

4-hydroxyphenyl retinamide (ISO)

5-fluorouracil (ISO)

acrolein (ISO)

aflatoxin B1 (EXP,ISO)

alpha-pinene (ISO)

ammonium chloride (EXP)

antimycin A (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

bleomycin A2 (ISO)

bortezomib (ISO)

C60 fullerene (EXP)

caffeine (ISO)

CGP 52608 (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

decabromodiphenyl ether (ISO)

diarsenic trioxide (ISO)

dibenzo[a,l]pyrene (ISO)

dibutyl phthalate (ISO)

ethanol (ISO)

formaldehyde (ISO)

HC toxin (ISO)

hydrogen peroxide (ISO)

irinotecan (ISO)

ivermectin (ISO)

methapyrilene (ISO)

nicotine (ISO)

Nor-9-carboxy-delta9-THC (ISO)

ozone (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

ponatinib (ISO)

quercetin (ISO)

SB 431542 (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (EXP,ISO)

thioacetamide (EXP)

trimellitic anhydride (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell differentiation (IBA)

cellular response to platelet-derived growth factor stimulus (ISO)

cellular response to retinoic acid (ISO)

cellular response to transforming growth factor beta stimulus (ISO)

innate immune response (IBA)

phosphorylation (IEA)

positive regulation of peptidyl-tyrosine phosphorylation (ISO)

positive regulation of transcription by RNA polymerase II (ISO)

protein autophosphorylation (IDA)

regulation of glucose transmembrane transport (ISO)

transmembrane receptor protein tyrosine kinase signaling pathway (IBA)

Cellular Component

actin filament (ISO)

cytoplasm (IEA)

cytosol (IEA,ISO)

extrinsic component of cytoplasmic side of plasma membrane (IBA)

glutamatergic synapse (IDA,IEP)

Golgi apparatus (ISO)

microtubule organizing center (IEA)

plasma membrane (ISO,TAS)

postsynaptic specialization, intracellular component (IDA,IEP)

Molecular Function

ATP binding (IEA)

enzyme binding (ISO)

epidermal growth factor receptor binding (IPI)

non-membrane spanning protein tyrosine kinase activity (IBA,IEA)

phosphotyrosine residue binding (ISO)

protein binding (ISO)

protein tyrosine kinase activity (IDA,ISO)

signaling receptor binding (IBA)

transmembrane transporter binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

eicosanoid signaling pathway (ISO)

ephrin - ephrin receptor bidirectional signaling axis (ISO)

glypican signaling pathway (ISO)

phosphatidylinositol 3-kinase class I signaling pathway (ISO)

platelet-derived growth factor signaling pathway (ISO)

Wnt signaling, non-canonical pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Identification of autophosphorylation sites in c-Yes purified from rat liver plasma membranes.	Ariki M, etal., J Biochem (Tokyo) 1997 Jan;121(1):104-11.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Interactions between Src family protein tyrosine kinases and PSD-95.	Kalia LV and Salter MW, Neuropharmacology. 2003 Nov;45(6):720-8.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8.	GOA pipeline	RGD automated data pipeline
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Caveolin-1 facilitates mechanosensitive protein kinase B (Akt) signaling in vitro and in vivo.	Sedding DG, etal., Circ Res. 2005 Apr 1;96(6):635-42. Epub 2005 Feb 24.
11.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
12.	A kinase cascade leading to Rab11-FIP5 controls transcytosis of the polymeric immunoglobulin receptor.	Su T, etal., Nat Cell Biol. 2010 Dec;12(12):1143-53. Epub 2010 Oct 31.
13.	MicroRNA-140 attenuates myocardial ischemia-reperfusion injury through suppressing mitochondria-mediated apoptosis by targeting YES1.	Yang S, etal., J Cell Biochem. 2019 Mar;120(3):3813-3821. doi: 10.1002/jcb.27663. Epub 2018 Sep 27.

Additional References at PubMed

PMID:1381360	PMID:9799234	PMID:10861086	PMID:11448999	PMID:11546805	PMID:12496267	PMID:12538589	PMID:12923167	PMID:14634819	PMID:15039424	PMID:16921024	PMID:17623777
PMID:18682436	PMID:18697750	PMID:19199708	PMID:20605918	PMID:20624904	PMID:21256972	PMID:21385842	PMID:21423176	PMID:21829547	PMID:22617836	PMID:23169788	PMID:23376485
PMID:25117412

Genomics

Comparative Map Data

Yes1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	9	113,200,256 - 113,275,942 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	113,200,256 - 113,299,837 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	121,684,273 - 121,760,004 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	126,813,413 - 126,889,144 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	125,159,312 - 125,235,046 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	121,802,471 - 121,918,906 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	121,802,673 - 121,902,678 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	121,252,194 - 121,327,422 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	112,516,831 - 112,564,072 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	9	110,304,110 - 110,380,060 (+)	NCBI		Celera
Cytogenetic Map	9	q38	NCBI

YES1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	18	721,588 - 812,753 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	18	721,588 - 812,546 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	18	721,588 - 812,243 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	18	711,592 - 802,327 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	18	711,591 - 802,327	NCBI
Celera	18	595,885 - 635,919 (-)	NCBI		Celera
Cytogenetic Map	18	p11.32	NCBI
HuRef	18	681,901 - 721,946 (-)	NCBI		HuRef
CHM1_1	18	720,957 - 811,714 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	18	875,925 - 969,846 (-)	NCBI		T2T-CHM13v2.0

Yes1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	32,768,502 - 32,844,410 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	32,768,515 - 32,844,401 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	32,611,171 - 32,687,066 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	32,611,171 - 32,687,057 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	32,913,606 - 32,989,430 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	32,887,814 - 32,963,638 (+)	NCBI		MGSCv36	mm8
Celera	5	30,085,521 - 30,153,048 (+)	NCBI		Celera
Cytogenetic Map	5	B1	NCBI
cM Map	5	17.33	NCBI

Yes1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955402	9,226,295 - 9,256,044 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955402	9,199,704 - 9,255,183 (+)	NCBI	ChiLan1.0	ChiLan1.0

YES1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	18	23,382,030 - 23,474,246 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	18	13,513,124 - 13,605,379 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	18	17,201,973 - 17,248,074 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	18	15,848,765 - 17,245,246 (+)	Ensembl	panpan1.1		panPan2

YES1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	67,532,790 - 67,598,285 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	67,532,790 - 67,598,285 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	66,986,484 - 67,051,985 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	67,598,792 - 67,664,338 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	67,598,792 - 67,664,338 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	67,275,521 - 67,341,129 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	67,287,110 - 67,352,610 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	67,589,051 - 67,654,785 (-)	NCBI		UU_Cfam_GSD_1.0

YES1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	105,505,479 - 105,600,687 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	105,505,944 - 105,600,694 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

YES1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	18	60,086,011 - 60,168,973 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	18	60,088,525 - 60,120,114 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	34,878,228 - 34,967,209 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Yes1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624770	11,190,595 - 11,221,512 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624770	11,190,103 - 11,275,823 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Yes1
63 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	175
Count of miRNA genes:	136
Interacting mature miRNAs:	152
Transcripts:	ENSRNOT00000056250, ENSRNOT00000056251
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
724544	Uae9	Urinary albumin excretion QTL 9	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	9	25268044	114175309	Rat

Markers in Region

D9Got128

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	113,266,747 - 113,267,037 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	121,868,615 - 121,868,975	NCBI	Rnor6.0
Rnor_5.0	9	121,318,158 - 121,318,518	UniSTS	Rnor5.0
RGSC_v3.4	9	112,554,135 - 112,554,435	RGD	RGSC3.4
RGSC_v3.4	9	112,554,148 - 112,554,435	UniSTS	RGSC3.4
RGSC_v3.1	9	112,763,627 - 112,763,915	RGD
Celera	9	110,370,870 - 110,371,155	UniSTS
RH 3.4 Map	9	846.6	RGD
RH 3.4 Map	9	846.6	UniSTS
Cytogenetic Map	9	q38	UniSTS

AI323763

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	113,273,825 - 113,273,918 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	121,875,764 - 121,875,856	NCBI	Rnor6.0
Rnor_5.0	9	121,325,307 - 121,325,399	UniSTS	Rnor5.0
RGSC_v3.4	9	112,561,956 - 112,562,048	UniSTS	RGSC3.4
Celera	9	110,377,944 - 110,378,036	UniSTS
Cytogenetic Map	9	q38	UniSTS

RH140391

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	113,273,683 - 113,273,918 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	121,875,622 - 121,875,856	NCBI	Rnor6.0
Rnor_5.0	9	121,325,165 - 121,325,399	UniSTS	Rnor5.0
RGSC_v3.4	9	112,561,814 - 112,562,048	UniSTS	RGSC3.4
Celera	9	110,377,802 - 110,378,036	UniSTS
RH 3.4 Map	9	833.01	UniSTS
Cytogenetic Map	9	q38	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2	32	24	14	12	14	2	2	68	34	37	11	2
Low	1	11	33	27	7	27	6	9	6	1	4		6
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001398584	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001398585	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_033298	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017596282	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017596283	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001839641	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001839642	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001839643	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001839644	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001839645	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001839646	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001839647	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001839648	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB037472	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC079403	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474043	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D82931	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ215740	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000215	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000056250 ⟹ ENSRNOP00000053093

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	9	121,831,716 - 121,873,578 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000056251 ⟹ ENSRNOP00000053094

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	113,200,325 - 113,274,017 (+)	Ensembl
Rnor_6.0 Ensembl	9	121,831,716 - 121,877,795 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000086534 ⟹ ENSRNOP00000072395

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	113,200,256 - 113,299,837 (+)	Ensembl
Rnor_6.0 Ensembl	9	121,802,673 - 121,902,678 (+)	Ensembl

RefSeq Acc Id:

NM_001398584 ⟹ NP_001385513

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	9	113,200,256 - 113,274,018 (+)	NCBI

RefSeq Acc Id:

NM_001398585 ⟹ NP_001385514

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	9	113,200,256 - 113,274,018 (+)	NCBI

RefSeq Acc Id:

NM_033298 ⟹ NP_150640

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	9	113,200,256 - 113,275,942 (+)	NCBI
Rnor_6.0	9	121,802,653 - 121,877,879 (+)	NCBI
Rnor_5.0	9	121,252,194 - 121,327,422 (+)	NCBI
RGSC_v3.4	9	112,516,831 - 112,564,072 (+)	RGD
Celera	9	110,304,110 - 110,380,060 (+)	RGD

Sequence:

show sequence

CCGGCGGCGAGAGGAGGAGAGAGGGAGGCCGTGGGGTGCGGGCGCCCGGGAATTCCCTCCTCCT
CAAGTAACGCGTCCCGGGCCGGCTGTGCGGCCGTCGCTGCCTCCCGGCGCCCCGCAAGCAGGAG
GTGGAGAAGGGAGAGGGCCCCGCGGGCGTCCGCCTCGGCCGGCCGCCTTCTCCCCGAGGCGACC
CGTGCGAGTGCGGCCGGACCCAGATTTGATAATGGGCTGCATTAAAAGTAAAGAAAACAAAAGT
CCAGCCATTAAATATACACCGGAAAATCCTACAGAGCCTGTAAACACAAGTGCCGGTCATTATG
GAGTGGAACATGCTACAGCTGCCACGACCTCTTCCACAAAGGGAGCATCAGCTAATTTTAACAG
TCTTTCCATGACACCCTTTGGAGGGTCCTCTGGGGTGACTCCTTTTGGAGGAGCATCTTCCTCA
TTCTCAGTGGTGCCAAGTTCATATCCTACAAGTTTAACAGGTGGTGTCACTATATTTGTGGCCT
TATATGATTATGAAGCTAGAACTACAGAAGACCTTTCCTTTAAGAAGGGTGAAAGATTTCAAAT
AATTAACAATACGGAAGGAGACTGGTGGGAAGCAAGATCAATTGCTACCGGAAAGAATGGTTAT
ATCCCTAGCAATTATGTAGCGCCTGCAGATTCCATTCAGGCAGAAGAATGGTATTTTGGCAAAA
TGGGGAGAAAAGATGCTGAAAGATTACTTCTGAATCCTGGGAATCAGCGAGGTATATTCTTAGT
AAGAGAAAGTGAAACTACTAAAGGTGCTTATTCCCTCTCAATTCGTGATTGGGATGAGGTAAGG
GGTGACAATGTGAAGCATTACAAAATCAGAAAACTTGACAACGGTGGATACTACATCACGACCA
GAGCTCAGTTTGATACTCTACAGAAACTGGTGAAGCATTACACAGAACATGCTGATGGATTATG
CCACAAATTAACAACCGTCTGTCCAACTGTGAAACCGCAGACTCAAGGTCTCGCAAAAGACGCT
TGGGAAATCCCTCGAGAGTCTTTGCGACTCGAGGTTAAACTAGGTCAAGGATGCTTTGGTGAAG
TGTGGATGGGAACATGGAATGGAACCACAAAAGTAGCAATCAAAACACTAAAGCCAGGTACAAT
GATGCCAGAAGCATTCCTTCAAGAAGCTCAGATAATGAAAAAATTAAGACACGATAAACTTGTT
CCGCTCTATGCAGTTGTTTCTGAAGAGCCAATTTATATTGTCACTGAGTTTATGTCAAAAGGAA
GCTTGTTAGATTTCCTTAAAGAAGGAGATGGAAAGTATTTGAAGCTTCCACAGCTGGTTGATAT
GGCTGCTCAGATTGCTGATGGCATGGCATATATTGAAAGAATGAACTATATTCACCGAGATCTC
CGAGCTGCTAATATTCTTGTGGGAGAAAATCTTGTATGCAAAATAGCAGATTTTGGCTTAGCAA
GACTAATTGAAGACAATGAATACACAGCAAGACAAGGTGCAAAATTTCCAATCAAGTGGACAGC
TCCTGAGGCTGCGCTTTATGGTCGATTTACGATAAAGTCAGATGTGTGGTCATTTGGAATTCTA
CAGACAGAGCTGGTAACAAAAGGAAGAGTGCCGTATCCAGAGGTCCTGAGTTCAATTCCCAGCA
ACCACATCGTGGCTCACAACCATCTGTAATGAGATCTGATGCCCTCTCCAGGTGTGTCTAAGGA
TAGCAACAGTGTACTCACATAAAGTAAATAAATAAATCTTAAAAAAAAAAAAAAAAAAAAAAAA
AAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001385513	(Get FASTA)	NCBI Sequence Viewer
	NP_001385514	(Get FASTA)	NCBI Sequence Viewer
	NP_150640	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH79403	(Get FASTA)	NCBI Sequence Viewer
	BAA11636	(Get FASTA)	NCBI Sequence Viewer
	BAB21451	(Get FASTA)	NCBI Sequence Viewer
	EDL90968	(Get FASTA)	NCBI Sequence Viewer
	F1LM93	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_150640 ⟸ NM_033298
- Peptide Label:	isoform 2
- UniProtKB:	F1LM93 (UniProtKB/Swiss-Prot), Q6AXQ3 (UniProtKB/TrEMBL), F1LM92 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGCIKSKENKSPAIKYTPENPTEPVNTSAGHYGVEHATAATTSSTKGASANFNSLSMTPFGGSS GVTPFGGASSSFSVVPSSYPTSLTGGVTIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWE ARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAY SLSIRDWDEVRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTV KPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQ IMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAY IERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT IKSDVWSFGILQTELVTKGRVPYPEVLSSIPSNHIVAHNHL hide sequence

RefSeq Acc Id:

ENSRNOP00000053094 ⟸ ENSRNOT00000056251

RefSeq Acc Id:

ENSRNOP00000053093 ⟸ ENSRNOT00000056250

RefSeq Acc Id:

ENSRNOP00000072395 ⟸ ENSRNOT00000086534

RefSeq Acc Id:	NP_001385514 ⟸ NM_001398585
- Peptide Label:	isoform 1
- UniProtKB:	F1LM93 (UniProtKB/Swiss-Prot), Q99PW1 (UniProtKB/TrEMBL), A6KFB6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	NP_001385513 ⟸ NM_001398584
- Peptide Label:	isoform 1
- UniProtKB:	F1LM93 (UniProtKB/Swiss-Prot), Q99PW1 (UniProtKB/TrEMBL), A6KFB6 (UniProtKB/TrEMBL)

Protein Domains

Protein kinase SH2 SH3

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1LM93-F1-model_v2	AlphaFold	F1LM93	1-541	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3977	AgrOrtholog
BioCyc Gene	G2FUF-26306	BioCyc
Ensembl Genes	ENSRNOG00000037227	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000053094	ENTREZGENE
	ENSRNOP00000053094.4	UniProtKB/TrEMBL
	ENSRNOP00000072395	ENTREZGENE
	ENSRNOP00000072395.2	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000056251	ENTREZGENE
	ENSRNOT00000056251.6	UniProtKB/TrEMBL
	ENSRNOT00000086534	ENTREZGENE
	ENSRNOT00000086534.2	UniProtKB/TrEMBL
Gene3D-CATH	3.30.505.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3 Domains	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7112783	IMAGE-MGC_LOAD
InterPro	Kinase-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ser-Thr/Tyr_kinase_cat_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH2_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3_domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tyr_kinase_AS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tyr_kinase_cat_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Yes_SH3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:24884	UniProtKB/TrEMBL
MGC_CLONE	MGC:94936	IMAGE-MGC_LOAD
NCBI Gene	24884	ENTREZGENE
PANTHER	TYROSINE-PROTEIN KINASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TYROSINE-PROTEIN KINASE YES	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Pkinase_Tyr	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Yes1	PhenoGen
PRINTS	SH2DOMAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3DOMAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TYRKINASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_TYR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	SH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TyrKc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF50044	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF55550	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF56112	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2K2V7_RAT	UniProtKB/TrEMBL
	A0A8J8XNH3_RAT	UniProtKB/TrEMBL
	A6KFB6	ENTREZGENE, UniProtKB/TrEMBL
	F1LM92	ENTREZGENE
	F1LM93	ENTREZGENE
	Q6AXQ3	ENTREZGENE, UniProtKB/TrEMBL
	Q99PW1	ENTREZGENE
	YES_RAT	UniProtKB/Swiss-Prot
UniProt Secondary	F1LM92	UniProtKB/TrEMBL
	Q99PW1	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-03-16	Yes1	YES proto-oncogene 1, Src family tyrosine kinase	Yes1	Yamaguchi sarcoma viral (v-yes) oncogene homolog 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-02-23	Yes1	Yamaguchi sarcoma viral (v-yes) oncogene homolog 1	Yes_predicted	Yamaguchi sarcoma viral (v-yes) oncogene homolog (predicted)	Data Merged	737654	APPROVED
2005-01-12	Yes_predicted	Yamaguchi sarcoma viral (v-yes) oncogene homolog (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL
2003-04-09	Yes1	Yamaguchi sarcoma viral (v-yes) oncogene homolog 1		Yamagichi sarcoma viral (v-yes-1) oncogene homolog 1	Name updated	629478	APPROVED
2002-06-10	Yes1	Yamagichi sarcoma viral (v-yes-1) oncogene homolog 1			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_cellular_localization	localized to the plasma membrane fraction	634514

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - PID (archival)