RGD Reference Report - MicroRNA-140 attenuates myocardial ischemia-reperfusion injury through suppressing mitochondria-mediated apoptosis by targeting YES1. - Rat Genome Database

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MicroRNA-140 attenuates myocardial ischemia-reperfusion injury through suppressing mitochondria-mediated apoptosis by targeting YES1.

Authors: Yang, Shuguo  Li, Haide  Chen, Lianghua 
Citation: Yang S, etal., J Cell Biochem. 2019 Mar;120(3):3813-3821. doi: 10.1002/jcb.27663. Epub 2018 Sep 27.
RGD ID: 329337366
Pubmed: PMID:30259997   (View Abstract at PubMed)
DOI: DOI:10.1002/jcb.27663   (Journal Full-text)

Myocardial ischemia-reperfusion (I/R) injury is thought to have its detrimental role in coronary heart disease (CHD), which is considered as the foremost cause of death all over the world. However, molecular mechanism in the progression of myocardial I/R injury is still unclear. The goal of this study was to investigate the expression and function of microRNA-140 (miR-140) in the process of myocardial I/R injury. The miR-140 expression level was analyzed in the myocardium with I/R injury and control myocardium using quantitative real-time polymerase chain reaction. Then the relation between the level of miR-140 and YES proto-oncogene 1 (YES1) was also investigated via luciferase reporter assay. Assessment of myocardial infarct size measurement of serum myocardial enzymes and electron microscopy analysis were used for analyzing the effect of miR-140 on myocardial I/R injury. We also used Western blot analysis to examine the expression levels of the mitochondrial fission-related proteins, Drp1 and Fis1. miR-140 is downregulated, and YES1 is upregulated after myocardial I/R injury. Overexpression of miR-140 could reduce the increase related to myocardial I/R injury in infarct size and myocardial enzymes, and it also could inhibit the expression of proteins related to mitochondrial morphology and myocardial I/R-induced mitochondrial apoptosis by targeting YES1. Taken together, these findings may provide a novel insight into the molecular mechanism of miR-140 and YES1 in the progression of myocardial I/R injury. MiR-140 might become a promising therapeutic target for treating myocardial I/R injury.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CASP3HumanMyocardial Reperfusion Injury amelioratesISOCasp3 (Mus musculus) RGD 
CASP9HumanMyocardial Reperfusion Injury amelioratesISOCasp9 (Mus musculus) RGD 
Casp3RatMyocardial Reperfusion Injury amelioratesISOCasp3 (Mus musculus) RGD 
Casp3MouseMyocardial Reperfusion Injury amelioratesIEP  RGD 
Casp9RatMyocardial Reperfusion Injury amelioratesISOCasp9 (Mus musculus) RGD 
Casp9MouseMyocardial Reperfusion Injury amelioratesIEP  RGD 
DNM1LHumanMyocardial Reperfusion Injury amelioratesISODnm1l (Mus musculus) RGD 
Dnm1lRatMyocardial Reperfusion Injury amelioratesISODnm1l (Mus musculus) RGD 
Dnm1lMouseMyocardial Reperfusion Injury amelioratesIEP  RGD 
FIS1HumanMyocardial Reperfusion Injury amelioratesISOFis1 (Mus musculus) RGD 
Fis1RatMyocardial Reperfusion Injury amelioratesISOFis1 (Mus musculus) RGD 
Fis1MouseMyocardial Reperfusion Injury amelioratesIEP  RGD 
MIR140HumanMyocardial Reperfusion Injury exacerbatesISOMir140 (Mus musculus) RGD 
Mir140MouseMyocardial Reperfusion Injury exacerbatesIMP  RGD 
Mir140RatMyocardial Reperfusion Injury exacerbatesISOMir140 (Mus musculus) RGD 
TNNI3HumanMyocardial Reperfusion Injury amelioratesISOTnni3 (Mus musculus) RGD 
Tnni3RatMyocardial Reperfusion Injury amelioratesISOTnni3 (Mus musculus) RGD 
Tnni3MouseMyocardial Reperfusion Injury amelioratesIEP  RGD 
YES1HumanMyocardial Reperfusion Injury  ISOYes1 (Mus musculus)mRNA and protein:increased expression:myocardium (mouse)RGD 
Yes1RatMyocardial Reperfusion Injury  ISOYes1 (Mus musculus)mRNA and protein:increased expression:myocardium (mouse)RGD 
Yes1MouseMyocardial Reperfusion Injury  IEP mRNA and protein:increased expression:myocardium (mouse)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Casp3  (caspase 3)
Casp9  (caspase 9)
Dnm1l  (dynamin 1-like)
Fis1  (fission, mitochondrial 1)
Mir140  (microRNA 140)
Tnni3  (troponin I3, cardiac type)
Yes1  (YES proto-oncogene 1, Src family tyrosine kinase)

Genes (Mus musculus)
Casp3  (caspase 3)
Casp9  (caspase 9)
Dnm1l  (dynamin 1-like)
Fis1  (fission, mitochondrial 1)
Mir140  (microRNA 140)
Tnni3  (troponin I, cardiac 3)
Yes1  (YES proto-oncogene 1, Src family tyrosine kinase)

Genes (Homo sapiens)
CASP3  (caspase 3)
CASP9  (caspase 9)
DNM1L  (dynamin 1 like)
FIS1  (fission, mitochondrial 1)
MIR140  (microRNA 140)
TNNI3  (troponin I3, cardiac type)
YES1  (YES proto-oncogene 1, Src family tyrosine kinase)


Additional Information