MRGPRX1 (MAS related GPR family member X1) - Rat Genome Database

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Gene: MRGPRX1 (MAS related GPR family member X1) Homo sapiens
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Symbol: MRGPRX1
Name: MAS related GPR family member X1
RGD ID: 1605552
HGNC Page HGNC:17962
Description: Enables transmembrane signaling receptor activity. Involved in cell surface receptor signaling pathway and response to chloroquine. Predicted to be located in cell surface. Predicted to be active in plasma membrane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: G protein-coupled receptor MRGX1; G protein-coupled receptor SNSR3; GPCR; Mas-related G protein-coupled receptor G2; mas-related G-protein coupled receptor member X1; MAS-related GPR, member X1; MGRG2; MRGX1; sensory neuron-specific G-protein coupled receptor 3/4; SNSR4
RGD Orthologs
Rat
Bonobo
Alliance Orthologs
More Info more info ...
Related Pseudogenes: MRGPRX10P   MRGPRX11P   MRGPRX6P   MRGPRX7P  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381118,933,499 - 18,939,414 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1118,933,499 - 18,939,414 (-)EnsemblGRCh38hg38GRCh38
GRCh371118,955,046 - 18,960,961 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361118,911,936 - 18,913,125 (-)NCBINCBI36Build 36hg18NCBI36
Celera1119,087,796 - 19,088,985 (-)NCBICelera
Cytogenetic Map11p15.1NCBI
HuRef1118,639,412 - 18,640,601 (-)NCBIHuRef
CHM1_11118,954,694 - 18,955,883 (-)NCBICHM1_1
T2T-CHM13v2.01119,031,499 - 19,037,414 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cell surface  (IC)
membrane  (IEA)
plasma membrane  (IBA,IEA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11551509   PMID:11850634   PMID:12044878   PMID:12477932   PMID:15489334   PMID:15782186   PMID:20004959   PMID:21873635   PMID:23074220   PMID:24583173   PMID:26582731   PMID:28223516  
PMID:28768771   PMID:28988117   PMID:31119828   PMID:31350433   PMID:33358893   PMID:33891544   PMID:37347749   PMID:37591889  


Genomics

Comparative Map Data
MRGPRX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381118,933,499 - 18,939,414 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1118,933,499 - 18,939,414 (-)EnsemblGRCh38hg38GRCh38
GRCh371118,955,046 - 18,960,961 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361118,911,936 - 18,913,125 (-)NCBINCBI36Build 36hg18NCBI36
Celera1119,087,796 - 19,088,985 (-)NCBICelera
Cytogenetic Map11p15.1NCBI
HuRef1118,639,412 - 18,640,601 (-)NCBIHuRef
CHM1_11118,954,694 - 18,955,883 (-)NCBICHM1_1
T2T-CHM13v2.01119,031,499 - 19,037,414 (-)NCBIT2T-CHM13v2.0
Mrgprb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81107,537,410 - 107,539,432 (-)NCBIGRCr8
mRatBN7.2198,401,140 - 98,403,162 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl198,401,538 - 98,415,284 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01104,023,700 - 104,049,356 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1104,023,738 - 104,024,682 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01105,085,669 - 105,086,626 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4198,479,104 - 98,480,042 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1198,557,417 - 98,558,155 (-)NCBI
Celera192,612,181 - 92,638,270 (-)NCBICelera
Cytogenetic Map1q22NCBI
LOC100972004
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2921,239,227 - 21,245,575 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11121,199,544 - 21,205,869 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01118,960,202 - 18,961,386 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11118,874,205 - 18,879,897 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1118,874,205 - 18,875,173 (-)Ensemblpanpan1.1panPan2

Variants

.
Variants in MRGPRX1
31 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11p15.1(chr11:17905089-19674505)x1 copy number loss See cases [RCV000052646] Chr11:17905089..19674505 [GRCh38]
Chr11:17926636..19696051 [GRCh37]
Chr11:17883212..19652627 [NCBI36]
Chr11:11p15.1		 pathogenic
GRCh38/hg38 11p15.5-13(chr11:202758-31726224)x3 copy number gain See cases [RCV000053613] Chr11:202758..31726224 [GRCh38]
Chr11:202758..31747772 [GRCh37]
Chr11:192758..31704348 [NCBI36]
Chr11:11p15.5-13		 pathogenic
NM_147199.3(MRGPRX1):c.956G>A (p.Arg319Lys) single nucleotide variant Malignant melanoma [RCV000069288] Chr11:18933829 [GRCh38]
Chr11:18955376 [GRCh37]
Chr11:18911952 [NCBI36]
Chr11:11p15.1		 not provided
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3		 pathogenic
GRCh38/hg38 11p15.1(chr11:18526222-20748125)x3 copy number gain See cases [RCV000134932] Chr11:18526222..20748125 [GRCh38]
Chr11:18547769..20769671 [GRCh37]
Chr11:18504345..20726247 [NCBI36]
Chr11:11p15.1		 uncertain significance
NM_147199.3(MRGPRX1):c.-359_*6143del deletion Gestational diabetes mellitus uncontrolled [RCV000161623] Chr11:18927673..18935143 [GRCh38]
Chr11:18949220..18956690 [GRCh37]
Chr11:11p15.1		 not provided
GRCh37/hg19 11p15.1(chr11:18908667-18956427)x3 copy number gain See cases [RCV000449108] Chr11:18908667..18956427 [GRCh37]
Chr11:11p15.1		 benign
GRCh37/hg19 11p15.1(chr11:18955543-19076609)x3 copy number gain See cases [RCV000447622] Chr11:18955543..19076609 [GRCh37]
Chr11:11p15.1		 benign
GRCh37/hg19 11p15.1-13(chr11:18536224-31923308)x1 copy number loss Aniridia 1 [RCV000420782] Chr11:18536224..31923308 [GRCh37]
Chr11:11p15.1-13		 pathogenic
GRCh37/hg19 11p15.1(chr11:18908667-19048572)x3 copy number gain See cases [RCV000445913] Chr11:18908667..19048572 [GRCh37]
Chr11:11p15.1		 benign
GRCh37/hg19 11p15.5-12(chr11:230615-37698540)x3 copy number gain See cases [RCV000511561] Chr11:230615..37698540 [GRCh37]
Chr11:11p15.5-12		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
NM_001393578.1(MRGPRX1):c.231C>G (p.Ser77Arg) single nucleotide variant not specified [RCV004326549] Chr11:18934554 [GRCh38]
Chr11:18956101 [GRCh37]
Chr11:11p15.1		 uncertain significance
GRCh37/hg19 11p15.5-14.3(chr11:230615-25584362)x3 copy number gain See cases [RCV000512225] Chr11:230615..25584362 [GRCh37]
Chr11:11p15.5-14.3		 pathogenic
GRCh37/hg19 11p15.5-13(chr11:230615-31995219)x3 copy number gain See cases [RCV000512477] Chr11:230615..31995219 [GRCh37]
Chr11:11p15.5-13		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p15.1(chr11:18939666-18956690)x1 copy number loss not provided [RCV000737453] Chr11:18939666..18956690 [GRCh37]
Chr11:11p15.1		 benign
GRCh37/hg19 11p15.1(chr11:18950705-18974860)x1 copy number loss not provided [RCV000737454] Chr11:18950705..18974860 [GRCh37]
Chr11:11p15.1		 benign
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
NM_001393578.1(MRGPRX1):c.164G>T (p.Arg55Leu) single nucleotide variant not provided [RCV000972479] Chr11:18934621 [GRCh38]
Chr11:18956168 [GRCh37]
Chr11:11p15.1		 benign
NM_001393578.1(MRGPRX1):c.730G>A (p.Val244Met) single nucleotide variant not specified [RCV004332142] Chr11:18934055 [GRCh38]
Chr11:18955602 [GRCh37]
Chr11:11p15.1		 uncertain significance
NM_001393578.1(MRGPRX1):c.87C>A (p.Ser29Arg) single nucleotide variant not specified [RCV004283921] Chr11:18934698 [GRCh38]
Chr11:18956245 [GRCh37]
Chr11:11p15.1		 uncertain significance
GRCh37/hg19 11p15.1(chr11:18894624-19554521)x3 copy number gain not provided [RCV000849349] Chr11:18894624..19554521 [GRCh37]
Chr11:11p15.1		 uncertain significance
NM_001393578.1(MRGPRX1):c.667C>T (p.Leu223=) single nucleotide variant not provided [RCV000890981] Chr11:18934118 [GRCh38]
Chr11:18955665 [GRCh37]
Chr11:11p15.1		 benign
GRCh37/hg19 11p15.5-13(chr11:235934-33826995)x3 copy number gain not provided [RCV001006372] Chr11:235934..33826995 [GRCh37]
Chr11:11p15.5-13		 pathogenic
GRCh37/hg19 11p15.3-13(chr11:11053978-34732891)x3 copy number gain not provided [RCV001006387] Chr11:11053978..34732891 [GRCh37]
Chr11:11p15.3-13		 pathogenic
GRCh37/hg19 11p15.2-14.1(chr11:13970757-27565888)x3 copy number gain not provided [RCV001006388] Chr11:13970757..27565888 [GRCh37]
Chr11:11p15.2-14.1		 pathogenic
NC_000011.9:g.(?_17552691)_(19213995_?)dup duplication Progressive myoclonic epilepsy type 7 [RCV001295201] Chr11:17552691..19213995 [GRCh37]
Chr11:11p15.1		 uncertain significance
NC_000011.9:g.(?_18420958)_(19213995_?)dup duplication Hypertrophic cardiomyopathy 12 [RCV001896615] Chr11:18420958..19213995 [GRCh37]
Chr11:11p15.1		 uncertain significance
NC_000011.9:g.(?_18418390)_(19204313_?)del deletion Hypertrophic cardiomyopathy 12 [RCV003113264] Chr11:18418390..19204313 [GRCh37]
Chr11:11p15.1		 uncertain significance
GRCh37/hg19 11p15.5-14.2(chr11:230615-26881146)x3 copy number gain See cases [RCV002286351] Chr11:230615..26881146 [GRCh37]
Chr11:11p15.5-14.2		 pathogenic
NM_001393578.1(MRGPRX1):c.563G>T (p.Cys188Phe) single nucleotide variant not specified [RCV004188948] Chr11:18934222 [GRCh38]
Chr11:18955769 [GRCh37]
Chr11:11p15.1		 likely benign
NM_001393578.1(MRGPRX1):c.646G>A (p.Val216Met) single nucleotide variant not specified [RCV004087450] Chr11:18934139 [GRCh38]
Chr11:18955686 [GRCh37]
Chr11:11p15.1		 uncertain significance
NM_001393578.1(MRGPRX1):c.347T>G (p.Val116Gly) single nucleotide variant not specified [RCV004122747] Chr11:18934438 [GRCh38]
Chr11:18955985 [GRCh37]
Chr11:11p15.1		 uncertain significance
NM_001393578.1(MRGPRX1):c.544G>T (p.Ala182Ser) single nucleotide variant not specified [RCV004099730] Chr11:18934241 [GRCh38]
Chr11:18955788 [GRCh37]
Chr11:11p15.1		 uncertain significance
NM_001393578.1(MRGPRX1):c.493T>C (p.Phe165Leu) single nucleotide variant not specified [RCV004088926] Chr11:18934292 [GRCh38]
Chr11:18955839 [GRCh37]
Chr11:11p15.1		 uncertain significance
NM_001393578.1(MRGPRX1):c.922C>T (p.Leu308Phe) single nucleotide variant not specified [RCV004182600] Chr11:18933863 [GRCh38]
Chr11:18955410 [GRCh37]
Chr11:11p15.1		 uncertain significance
NM_001393578.1(MRGPRX1):c.404C>T (p.Pro135Leu) single nucleotide variant not specified [RCV004073946] Chr11:18934381 [GRCh38]
Chr11:18955928 [GRCh37]
Chr11:11p15.1		 uncertain significance
NM_001393578.1(MRGPRX1):c.895T>C (p.Ser299Pro) single nucleotide variant not specified [RCV004314846] Chr11:18933890 [GRCh38]
Chr11:18955437 [GRCh37]
Chr11:11p15.1		 likely benign
NM_001393578.1(MRGPRX1):c.961G>C (p.Glu321Gln) single nucleotide variant not specified [RCV004272285] Chr11:18933824 [GRCh38]
Chr11:18955371 [GRCh37]
Chr11:11p15.1		 uncertain significance
NM_001393578.1(MRGPRX1):c.208G>T (p.Ala70Ser) single nucleotide variant not specified [RCV004278155] Chr11:18934577 [GRCh38]
Chr11:18956124 [GRCh37]
Chr11:11p15.1		 uncertain significance
NM_001393578.1(MRGPRX1):c.95T>G (p.Val32Gly) single nucleotide variant not specified [RCV004252915] Chr11:18934690 [GRCh38]
Chr11:18956237 [GRCh37]
Chr11:11p15.1		 likely benign
NM_001393578.1(MRGPRX1):c.846A>G (p.Gln282=) single nucleotide variant not provided [RCV003397975] Chr11:18933939 [GRCh38]
Chr11:18955486 [GRCh37]
Chr11:11p15.1		 likely benign
NM_001393578.1(MRGPRX1):c.126G>A (p.Leu42=) single nucleotide variant not provided [RCV003394778] Chr11:18934659 [GRCh38]
Chr11:18956206 [GRCh37]
Chr11:11p15.1		 likely benign
NM_001393578.1(MRGPRX1):c.690G>A (p.Leu230=) single nucleotide variant not provided [RCV003409284] Chr11:18934095 [GRCh38]
Chr11:18955642 [GRCh37]
Chr11:11p15.1		 likely benign
NM_001393578.1(MRGPRX1):c.598A>G (p.Ile200Val) single nucleotide variant not provided [RCV003409285] Chr11:18934187 [GRCh38]
Chr11:18955734 [GRCh37]
Chr11:11p15.1		 likely benign
NM_001393578.1(MRGPRX1):c.579G>T (p.Gly193=) single nucleotide variant not provided [RCV003409286] Chr11:18934206 [GRCh38]
Chr11:18955753 [GRCh37]
Chr11:11p15.1		 likely benign
NM_001393578.1(MRGPRX1):c.578G>T (p.Gly193Val) single nucleotide variant not provided [RCV003409287] Chr11:18934207 [GRCh38]
Chr11:18955754 [GRCh37]
Chr11:11p15.1		 likely benign
NM_001393578.1(MRGPRX1):c.606T>C (p.Ile202=) single nucleotide variant not provided [RCV003397976] Chr11:18934179 [GRCh38]
Chr11:18955726 [GRCh37]
Chr11:11p15.1		 likely benign
NM_001393578.1(MRGPRX1):c.23T>G (p.Leu8Trp) single nucleotide variant not specified [RCV004499417] Chr11:18934762 [GRCh38]
Chr11:18956309 [GRCh37]
Chr11:11p15.1		 likely benign
NM_001393578.1(MRGPRX1):c.930G>C (p.Glu310Asp) single nucleotide variant not specified [RCV004501449] Chr11:18933855 [GRCh38]
Chr11:18955402 [GRCh37]
Chr11:11p15.1		 uncertain significance
NM_001393578.1(MRGPRX1):c.216C>G (p.Asp72Glu) single nucleotide variant not specified [RCV004499412] Chr11:18934569 [GRCh38]
Chr11:18956116 [GRCh37]
Chr11:11p15.1		 uncertain significance
NM_001393578.1(MRGPRX1):c.782C>A (p.Ser261Tyr) single nucleotide variant not specified [RCV004501437] Chr11:18934003 [GRCh38]
Chr11:18955550 [GRCh37]
Chr11:11p15.1		 uncertain significance
NM_001393578.1(MRGPRX1):c.301G>A (p.Val101Met) single nucleotide variant not specified [RCV004499421] Chr11:18934484 [GRCh38]
Chr11:18956031 [GRCh37]
Chr11:11p15.1		 uncertain significance
NM_001393578.1(MRGPRX1):c.686G>A (p.Gly229Asp) single nucleotide variant not specified [RCV004501428] Chr11:18934099 [GRCh38]
Chr11:18955646 [GRCh37]
Chr11:11p15.1		 uncertain significance
NC_000011.9:g.(?_18418390)_(19213995_?)del deletion Hypertrophic cardiomyopathy 12 [RCV004580268] Chr11:18418390..19213995 [GRCh37]
Chr11:11p15.1		 pathogenic
NM_001393578.1(MRGPRX1):c.949G>A (p.Gly317Arg) single nucleotide variant not specified [RCV004643558] Chr11:18933836 [GRCh38]
Chr11:18955383 [GRCh37]
Chr11:11p15.1		 uncertain significance
NM_001393578.1(MRGPRX1):c.481T>C (p.Cys161Arg) single nucleotide variant not specified [RCV004643559] Chr11:18934304 [GRCh38]
Chr11:18955851 [GRCh37]
Chr11:11p15.1		 uncertain significance
NM_001393578.1(MRGPRX1):c.88C>T (p.Leu30Phe) single nucleotide variant not specified [RCV004629122] Chr11:18934697 [GRCh38]
Chr11:18956244 [GRCh37]
Chr11:11p15.1		 likely benign
NM_001393578.1(MRGPRX1):c.379C>T (p.Pro127Ser) single nucleotide variant not specified [RCV004629123] Chr11:18934406 [GRCh38]
Chr11:18955953 [GRCh37]
Chr11:11p15.1		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:416
Count of miRNA genes:341
Interacting mature miRNAs:352
Transcripts:ENST00000302797, ENST00000526914
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576345LVC1_HLeft ventricular contractility QTL 1 (human)3.93Left ventricular contractility11797076733970767Human
2289313BW388_HBody weight QTL 388 (human)1.570.00356Body fat amountabdominal11443467130434671Human
1559107SCL32_HSerum cholesterol level QTL 32 (human)3.27Lipid levelLDL cholesterol11289243028892430Human
1559104SCL15_HSerum cholesterol level QTL 15 (human)2.60.06Lipid levelhyperlipidemia susceptibility111589236841892368Human
1559113SCL31_HSerum cholesterol level QTL 31 (human)3.72Lipid levelLDL cholesterol11289243028892430Human

Markers in Region
D11S3578  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371118,971,002 - 18,971,269UniSTSGRCh37
GRCh371118,948,880 - 18,949,149UniSTSGRCh37
Build 361118,905,456 - 18,905,725RGDNCBI36
Celera1119,081,316 - 19,081,585RGD
Celera1119,103,479 - 19,103,746UniSTS
Cytogenetic Map11p15.1UniSTS
HuRef1118,632,934 - 18,633,203UniSTS
HuRef1118,654,950 - 18,655,217UniSTS
D11S2376  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371118,953,318 - 18,953,492UniSTSGRCh37
Build 361118,909,894 - 18,910,068RGDNCBI36
Celera1119,085,754 - 19,085,928RGD
Cytogenetic Map11p15.1UniSTS
HuRef1118,637,370 - 18,637,544UniSTS
Whitehead-RH Map1163.3UniSTS
Whitehead-YAC Contig Map11 UniSTS
NCBI RH Map11129.6UniSTS
MRGX1__6155  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371118,955,171 - 18,956,051UniSTSGRCh37
Build 361118,911,747 - 18,912,627RGDNCBI36
Celera1119,087,607 - 19,088,487RGD
HuRef1118,639,223 - 18,640,103UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
44 95 303 80 537 69 98 2 60 60 47 444 302 238 2 135 40 270 41 13

Sequence


Ensembl Acc Id: ENST00000302797   ⟹   ENSP00000305766
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1118,933,813 - 18,935,002 (-)Ensembl
Ensembl Acc Id: ENST00000526914   ⟹   ENSP00000499076
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1118,933,499 - 18,939,414 (-)Ensembl
RefSeq Acc Id: NM_001393578   ⟹   NP_001380507
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381118,933,499 - 18,939,414 (-)NCBI
T2T-CHM13v2.01119,031,499 - 19,037,414 (-)NCBI
Sequence:
RefSeq Acc Id: NM_147199   ⟹   NP_671732
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381118,933,499 - 18,935,002 (-)NCBI
GRCh371118,955,360 - 18,956,549 (-)RGD
Build 361118,911,936 - 18,913,125 (-)NCBI Archive
Celera1119,087,796 - 19,088,985 (-)RGD
HuRef1118,639,412 - 18,640,601 (-)ENTREZGENE
CHM1_11118,954,694 - 18,955,883 (-)NCBI
T2T-CHM13v2.01119,031,499 - 19,033,002 (-)NCBI
Sequence:
RefSeq Acc Id: NP_671732   ⟸   NM_147199
- UniProtKB: Q8TDD8 (UniProtKB/Swiss-Prot),   Q4V9L2 (UniProtKB/Swiss-Prot),   Q8TDD9 (UniProtKB/Swiss-Prot),   Q96LB2 (UniProtKB/Swiss-Prot),   W8W3P5 (UniProtKB/TrEMBL),   B5B0C6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000499076   ⟸   ENST00000526914
Ensembl Acc Id: ENSP00000305766   ⟸   ENST00000302797
RefSeq Acc Id: NP_001380507   ⟸   NM_001393578
- UniProtKB: Q96LB2 (UniProtKB/Swiss-Prot),   Q8TDD8 (UniProtKB/Swiss-Prot),   Q4V9L2 (UniProtKB/Swiss-Prot),   Q8TDD9 (UniProtKB/Swiss-Prot),   W8W3P5 (UniProtKB/TrEMBL),   B5B0C6 (UniProtKB/TrEMBL)
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q96LB2-F1-model_v2 AlphaFold Q96LB2 1-322 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:17962 AgrOrtholog
COSMIC MRGPRX1 COSMIC
Ensembl Genes ENSG00000170255 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000302797 ENTREZGENE
  ENST00000302797.4 UniProtKB/Swiss-Prot
  ENST00000526914 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000526914.2 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000170255 GTEx
HGNC ID HGNC:17962 ENTREZGENE
Human Proteome Map MRGPRX1 Human Proteome Map
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MRGPCRFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:259249 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 259249 ENTREZGENE
OMIM 607227 OMIM
PANTHER PTHR11334 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11334:SF22 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA142671334 PharmGKB
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MRGPCRFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A494C1K4_HUMAN UniProtKB/TrEMBL
  B5B0C6 ENTREZGENE, UniProtKB/TrEMBL
  MRGX1_HUMAN UniProtKB/Swiss-Prot
  Q4V9L2 ENTREZGENE
  Q8TDD8 ENTREZGENE
  Q8TDD9 ENTREZGENE
  Q96LB2 ENTREZGENE
  W8W3P5 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q4V9L2 UniProtKB/Swiss-Prot
  Q8TDD8 UniProtKB/Swiss-Prot
  Q8TDD9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-01 MRGPRX1  MAS related GPR family member X1    MAS-related GPR, member X1  Symbol and/or name change 5135510 APPROVED