Aia16 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Aia16 (Adjuvant induced arthritis QTL 16) Rattus norvegicus

Symbol: Aia16
Name: Adjuvant induced arthritis QTL 16
RGD ID: 2317035
Trait: joint integrity trait   (VT:0010548)    
Measurement Type: right rear ankle joint diameter   (CMO:0002150)    
LOD Score: 2.71
P Value: Not Available
Variance: 9.5
Inheritance Type: dominant
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8771,103,011 - 106,126,789RGD_MAPPER_PIPELINE
mRatBN7.2759,238,038 - 104,238,038RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0768,518,460 - 113,518,460RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0768,456,672 - 113,456,672RGDRnor5.0
RGSC_v3.4765,025,373 - 110,025,373RGDRGSC3.4
Cross Type: intercross
Strains Crossed: F344/NCrl LEW/Crl 
JBrowse: View Region in Genome Browser (JBrowse)
Model




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Aia16Ratinflammatory bowel disease  IAGP 2316974induced by peptidoglycan-polysaccharideRGD 
Aia16Ratrheumatoid arthritis  IAGP 2316974induced by peptidoglycan-polysaccharideRGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Aia16Ratjoint inflammation  IDA 2316974induced by peptidoglycan-polysaccharideRGD 

Clinical Measurement
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Aia16Ratright rear ankle joint diameter  IDA 2316974 RGD 

Experimental Condition
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Aia16Ratpeptidoglycan-polysaccharide  IDA 2316974 RGD 

Measurement Method
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Aia16Ratin vivo caliper method  IDA 2316974 RGD 

Rat Strain
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Aia16RatF344/NCrl  IEA 2316974 RGD 
Aia16RatLEW/Crl  IEA 2316974 RGD 

Vertebrate Trait
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Aia16Ratjoint integrity trait  IDA 2316974 RGD 


#
Reference Title
Reference Citation
1. Genetic dissection of granulomatous enterocolitis and arthritis in the intramural peptidoglycan-polysaccharide-treated rat model of IBD. Bleich A, etal., Inflamm Bowel Dis. 2009 Jun 12;15(12):1794-1802.


1 to 20 of 423 rows
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD ID
Symbol
Name
Chr
Start
Stop
Species
1589429Tafa2TAFA chemokine like family member 275894259859418640Rat
40952871LOC120093870basic proline-rich protein-like75944207559443292Rat
41098039LOC120093624uncharacterized LOC12009362475952784359540971Rat
41286787Crb1-ps3crumbs cell polarity complex component 1, pseudogene 375958331659598561Rat
41375035LOC120093987small nucleolar RNA SNORA1775967884959678980Rat
40939206Ftl1-ps8ferritin light chain 1, pseudogene 876082544560837640Rat
7695057LOC102552186uncharacterized LOC10255218676097594361088913Rat
3691Slc16a7solute carrier family 16 member 776104366761211547Rat
7654942LOC102552637uncharacterized LOC10255263776144449561496656Rat
7628604LOC102552423uncharacterized LOC10255242376149810261533554Rat
1561255Lrig3leucine-rich repeats and immunoglobulin-like domains 376181631361866275Rat
40991943LOC120093626uncharacterized LOC12009362676193670861940112Rat
1559995Dppa5l1developmental pluripotency associated 5 like 176252504462526042Rat
41034435Trnat-agu22transfer RNA threonine (anticodon AGU) 2276256550262565574Rat
41075389LOC120093627uncharacterized LOC12009362776262278762636248Rat
11399049LOC108351471uncharacterized LOC10835147176268101762702138Rat
40988719LOC120093981small nucleolar RNA SNORA1776268242462682554Rat
1597486Park7-ps1Parkinsonism associated deglycase, pseudogene 176270611562706995Rat
7525893LOC102557532uncharacterized LOC10255753276270896262710729Rat
1588587Atp23ATP23 metallopeptidase and ATP synthase assembly factor homolog76271475262729893Rat

1 to 20 of 423 rows
1 to 20 of 555 rows
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Expected Size
Chr
Start
Stop
Species
Match
10935D7Wox1413179359564793595780Ratregion
10936D7Arb520479359562793595833Ratregion
10937D7Wox1515979359562093595781Ratregion
10938D7Wox2911979359563393595754Ratregion
10939D7Mit2721079359563193595843Ratregion
33969D7Mit423979481108594811326Ratregion
34172D7Mgh1221776775960667759823Ratregion
34499D7Mgh713076973622669736356Ratregion
34555D7Mgh614879141244491412594Ratregion
34713D7Mgh1623679125631191256547Ratregion
33648D7Mit513778022129980221436Ratregion
33749D7Mit325679973595699736220Ratregion
36015D7Rat2115579128113091281285Ratregion
37374D7Rat991997104237839104238038Ratregion
35180D7Rat4317076173665261736830Ratregion
35264D7Rat1814879801139698011544Ratregion
36932D7Rat1714879479587794796025Ratregion
37144D7Rat7414077382920473829340Ratregion
37642D7Rat11224678519688685197132Ratregion
37710D7Rat19018879032403890324226Ratregion
1 to 20 of 555 rows

Flank 1: (D7Rat24)
Rat AssemblyChrPosition (strand)Source
GRCr8771,103,011 - 71,103,163 (+)Marker Load Pipeline
Celera766,281,598 - 66,281,749UniSTS
RH 3.4 Map7638.8UniSTS
RH 3.4 Map7638.8RGD
SHRSP x BN Map744.39RGD
SHRSP x BN Map744.39UniSTS
FHH x ACI Map734.52RGD
Cytogenetic Map7q22UniSTS
Flank 2: (D7Rat99)
Rat AssemblyChrPosition (strand)Source
GRCr87106,126,590 - 106,126,789 (+)Marker Load Pipeline
mRatBN7.27104,237,839 - 104,238,038 (+)MAPPER
Rnor_6.07113,518,262 - 113,518,460NCBI
Rnor_5.07113,456,474 - 113,456,672UniSTS
RGSC_v3.47110,025,175 - 110,025,373UniSTS
Celera7100,657,078 - 100,657,276UniSTS
RH 3.4 Map1703.2RGD
RH 3.4 Map1703.2UniSTS
RH 2.0 Map1441.1RGD
SHRSP x BN Map760.22RGD


1 to 10 of 76 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat

1 to 10 of 76 rows


Note Type Note Reference
qtl_cross_type intercross  
qtl_general software used: MapQTL software, Student's t-tests, median tests 2316974
qtl_general inducing agent: peptidoglycan-polysaccharide (PG-PS) polymers 2316974
qtl_general measurement method: animals were anesthetized, intestines exposed and 0.05 mL PG-PS suspension was injected; after 24 days these animals were exsanguinated and joint diameter of the right rear ankle measured on 21st day of the treatment 2316974
qtl_general number of animals used: 168 F2 females 2316974
qtl_general on day 24 LOD=2.09 2316974