Kif5a (kinesin family member 5A) - Rat Genome Database

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Gene: Kif5a (kinesin family member 5A) Rattus norvegicus
Analyze
Symbol: Kif5a
Name: kinesin family member 5A
RGD ID: 1303035
Description: Enables scaffold protein binding activity. Involved in several processes, including axonal transport; cellular response to ethanol; and forebrain development. Located in several cellular components, including P-body; central region of growth cone; and perikaryon. Part of kinesin complex. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; hereditary spastic paraplegia 10; multiple sclerosis; prostate cancer; and rheumatoid arthritis. Orthologous to human KIF5A (kinesin family member 5A); PARTICIPATES IN mitochondria transport pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: kinesin heavy chain isoform 5A; kinesin heavy chain neuron-specific 1; neuronal kinesin heavy chain; NKHC
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2763,051,894 - 63,089,024 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl763,049,424 - 63,092,858 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx764,941,174 - 64,978,298 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0767,143,590 - 67,180,714 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0766,944,692 - 66,982,059 (-)NCBIRnor_WKY
Rnor_6.0770,515,832 - 70,552,897 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,513,343 - 70,556,827 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0770,693,375 - 70,727,047 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4767,183,575 - 67,220,766 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1767,204,304 - 67,241,496 (-)NCBI
Celera760,193,348 - 60,229,555 (-)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The autoimmune disease-associated KIF5A, CD226 and SH2B3 gene variants confer susceptibility for multiple sclerosis. Alcina A, etal., Genes Immun. 2010 Jul;11(5):439-45. doi: 10.1038/gene.2010.30. Epub 2010 May 27.
2. Diabetes alters KIF1A and KIF5B motor proteins in the hippocampus. Baptista FI, etal., PLoS One. 2013 Jun 12;8(6):e65515. doi: 10.1371/journal.pone.0065515. Print 2013.
3. Hereditary spastic paraplegia: a novel mutation and expansion of the phenotype variability in SPG10. Carosi L, etal., J Neurol Neurosurg Psychiatry. 2015 Jun;86(6):702-4. doi: 10.1136/jnnp-2014-308625. Epub 2014 Oct 28.
4. Association of variants in MMEL1 and CTLA4 with rheumatoid arthritis in the Han Chinese population. Danoy P, etal., Ann Rheum Dis. 2011 Oct;70(10):1793-7. doi: 10.1136/ard.2010.144576. Epub 2011 Jul 21.
5. Evidence of kinesin heavy chain (KIF5A) involvement in pure hereditary spastic paraplegia. Fichera M, etal., Neurology. 2004 Sep 28;63(6):1108-10.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. MAP2 Defines a Pre-axonal Filtering Zone to Regulate KIF1- versus KIF5-Dependent Cargo Transport in Sensory Neurons. Gumy LF, etal., Neuron. 2017 Apr 19;94(2):347-362.e7. doi: 10.1016/j.neuron.2017.03.046.
9. Replication of European rheumatoid arthritis loci in a Pakistani population. Jalil SF, etal., J Rheumatol. 2013 Apr;40(4):401-7. doi: 10.3899/jrheum.121050. Epub 2013 Feb 1.
10. Axonal transport deficit in a KIF5A( -/- ) mouse model. Karle KN, etal., Neurogenetics. 2012 May;13(2):169-79. doi: 10.1007/s10048-012-0324-y. Epub 2012 Apr 1.
11. Kinesin expression in the central nervous system of humans and transgenic hSOD1G93A mice with amyotrophic lateral sclerosis. Kuzma-Kozakiewicz M, etal., Neurodegener Dis. 2013;12(2):71-80. doi: 10.1159/000339529. Epub 2012 Sep 21.
12. Regulation of mitochondrial transport in neurons. Lin MY and Sheng ZH, Exp Cell Res. 2015 May 15;334(1):35-44. doi: 10.1016/j.yexcr.2015.01.004. Epub 2015 Jan 19.
13. The mitochondrial and autosomal mutation landscapes of prostate cancer. Lindberg J, etal., Eur Urol. 2013 Apr;63(4):702-8. doi: 10.1016/j.eururo.2012.11.053. Epub 2012 Dec 5.
14. Hereditary spastic paraplegia in Greece: characterisation of a previously unexplored population using next-generation sequencing. Lynch DS, etal., Eur J Hum Genet. 2016 Jun;24(6):857-63. doi: 10.1038/ejhg.2015.200. Epub 2015 Sep 16.
15. Huntingtin mediates dendritic transport of beta-actin mRNA in rat neurons. Ma B, etal., Sci Rep. 2011;1:140. Epub 2011 Nov 3.
16. Beta-dystrobrevin interacts directly with kinesin heavy chain in brain. Macioce P, etal., J Cell Sci 2003 Dec 1;116(Pt 23):4847-56.
17. Rotenone-dependent changes of anterograde motor protein expression and mitochondrial mobility in brain areas related to neurodegenerative diseases. Melo TQ, etal., Cell Mol Neurobiol. 2013 Apr;33(3):327-35. doi: 10.1007/s10571-012-9898-z. Epub 2012 Dec 22.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. A novel KIF5A mutation in an Italian family marked by spastic paraparesis and congenital deafness. Muglia M, etal., J Neurol Sci. 2014 Aug 15;343(1-2):218-20. doi: 10.1016/j.jns.2014.05.063. Epub 2014 Jun 5.
20. Molecular motor KIF5A is essential for GABA(A) receptor transport, and KIF5A deletion causes epilepsy. Nakajima K, etal., Neuron. 2012 Dec 6;76(5):945-61. doi: 10.1016/j.neuron.2012.10.012.
21. Activity-dependent synaptic localization of processing bodies and their role in dendritic structural plasticity. Oh JY, etal., J Cell Sci. 2013 May 1;126(Pt 9):2114-23. doi: 10.1242/jcs.125690. Epub 2013 Mar 13.
22. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
23. A kinesin heavy chain (KIF5A) mutation in hereditary spastic paraplegia (SPG10). Reid E, etal., Am J Hum Genet. 2002 Nov;71(5):1189-94. Epub 2002 Sep 24.
24. GOA pipeline RGD automated data pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Chronic alcohol exposure affects the cell components involved in membrane traffic in neuronal dendrites. Romero AM, etal., Neurotox Res. 2015 Jan;27(1):43-54. doi: 10.1007/s12640-014-9484-x. Epub 2014 Jul 15.
28. SPG10 is a rare cause of spastic paraplegia in European families. Schüle R, etal., J Neurol Neurosurg Psychiatry. 2008 May;79(5):584-7. doi: 10.1136/jnnp.2007.137596. Epub 2008 Feb 1.
29. DISC1 regulates neurotrophin-induced axon elongation via interaction with Grb2. Shinoda T, etal., J Neurosci. 2007 Jan 3;27(1):4-14.
30. c-Jun NH2-terminal kinase (JNK)-interacting protein-3 (JIP3) regulates neuronal axon elongation in a kinesin- and JNK-dependent manner. Sun T, etal., J Biol Chem. 2013 May 17;288(20):14531-43. doi: 10.1074/jbc.M113.464453. Epub 2013 Apr 10.
31. DISC1 regulates the transport of the NUDEL/LIS1/14-3-3epsilon complex through kinesin-1. Taya S, etal., J Neurosci. 2007 Jan 3;27(1):15-26.
32. Proteomic detection of cancer in asbestosis patients using SELDI-TOF discovered serum protein biomarkers. Tooker BC, etal., Biomarkers. 2011 Mar;16(2):181-91. doi: 10.3109/1354750X.2010.543289. Epub 2011 Jan 14.
33. Differential expression of ubiquitous and neuronal kinesin heavy chains during differentiation of human neuroblastoma and PC12 cells. Vignali G, etal., Eur J Neurosci. 1996 Mar;8(3):536-44.
34. Expression of neuronal kinesin heavy chain is developmentally regulated in the central nervous system of the rat. Vignali G, etal., J Neurochem. 1997 Nov;69(5):1840-9.
Additional References at PubMed
PMID:7514426   PMID:11986669   PMID:15644324   PMID:16018997   PMID:16301330   PMID:17360631   PMID:18539120   PMID:19946888   PMID:20152113   PMID:21048148   PMID:21411631   PMID:21976701  
PMID:22539840   PMID:28886967   PMID:29476059   PMID:30053369   PMID:31904090   PMID:34348158   PMID:36214718   PMID:36862119  


Genomics

Comparative Map Data
Kif5a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2763,051,894 - 63,089,024 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl763,049,424 - 63,092,858 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx764,941,174 - 64,978,298 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0767,143,590 - 67,180,714 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0766,944,692 - 66,982,059 (-)NCBIRnor_WKY
Rnor_6.0770,515,832 - 70,552,897 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,513,343 - 70,556,827 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0770,693,375 - 70,727,047 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4767,183,575 - 67,220,766 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1767,204,304 - 67,241,496 (-)NCBI
Celera760,193,348 - 60,229,555 (-)NCBICelera
Cytogenetic Map7q22NCBI
KIF5A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381257,550,044 - 57,586,633 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1257,546,026 - 57,586,633 (+)EnsemblGRCh38hg38GRCh38
GRCh371257,943,827 - 57,980,416 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361256,230,114 - 56,264,821 (+)NCBINCBI36Build 36hg18NCBI36
Build 341256,230,113 - 56,264,821NCBI
Celera1257,599,677 - 57,634,382 (+)NCBICelera
Cytogenetic Map12q13.3NCBI
HuRef1254,981,745 - 55,016,257 (+)NCBIHuRef
CHM1_11257,911,685 - 57,946,386 (+)NCBICHM1_1
T2T-CHM13v2.01257,518,283 - 57,554,872 (+)NCBIT2T-CHM13v2.0
Kif5a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910127,061,564 - 127,102,217 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10127,061,565 - 127,099,217 (-)EnsemblGRCm39 Ensembl
GRCm3810127,225,695 - 127,266,348 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,225,696 - 127,263,348 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710126,662,751 - 126,700,419 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610126,628,648 - 126,666,029 (-)NCBIMGSCv36mm8
Celera10129,618,645 - 129,655,868 (-)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1074.5NCBI
Kif5a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554585,287,111 - 5,310,962 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554585,264,274 - 5,310,962 (+)NCBIChiLan1.0ChiLan1.0
KIF5A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11236,751,196 - 36,787,946 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01231,340,201 - 31,376,849 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11231,599,376 - 31,635,677 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1231,599,376 - 31,635,327 (-)Ensemblpanpan1.1panPan2
KIF5A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1101,637,007 - 1,666,790 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl101,636,932 - 1,664,767 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha101,700,232 - 1,729,959 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0101,646,391 - 1,676,129 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl101,646,235 - 1,676,121 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1101,624,071 - 1,653,916 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0101,865,983 - 1,895,693 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0101,990,984 - 2,020,928 (+)NCBIUU_Cfam_GSD_1.0
Kif5a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494557,137,419 - 57,172,692 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366461,697,492 - 1,732,832 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366461,697,531 - 1,730,376 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KIF5A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl522,816,854 - 22,851,973 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1522,813,617 - 22,851,976 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
KIF5A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11153,458,795 - 53,493,801 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037192,467,068 - 192,505,360 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kif5a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480210,375,774 - 10,409,566 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480210,375,132 - 10,409,575 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kif5a
125 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:595
Count of miRNA genes:263
Interacting mature miRNAs:334
Transcripts:ENSRNOT00000007721
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72673740163902784Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73429328279293282Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73429328279293282Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73796056982960569Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74725178365728867Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)759238038104238038Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)761074194106074194Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)762004452101773158Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)762004452101773158Rat

Markers in Region
BF388221  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2763,050,720 - 63,050,898 (+)MAPPERmRatBN7.2
Rnor_6.0770,514,659 - 70,514,836NCBIRnor6.0
Rnor_5.0770,692,202 - 70,692,379UniSTSRnor5.0
RGSC_v3.4767,182,402 - 67,182,579UniSTSRGSC3.4
Celera760,192,175 - 60,192,352UniSTS
Cytogenetic Map7q22UniSTS
Kif5a  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2763,056,621 - 63,058,321 (+)MAPPERmRatBN7.2
Rnor_6.0770,520,496 - 70,522,195NCBIRnor6.0
Rnor_5.0770,694,646 - 70,696,345UniSTSRnor5.0
RGSC_v3.4767,188,357 - 67,190,056UniSTSRGSC3.4
Celera760,196,964 - 60,198,663UniSTS
Cytogenetic Map7q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 72 3
Low 3 40 30 14 19 14 8 11 2 35 38 11 8
Below cutoff 3 27 27 27

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000007721   ⟹   ENSRNOP00000007721
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl763,049,424 - 63,092,858 (-)Ensembl
Rnor_6.0 Ensembl770,513,343 - 70,556,827 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000080594   ⟹   ENSRNOP00000071539
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl763,049,424 - 63,089,064 (-)Ensembl
Rnor_6.0 Ensembl770,515,832 - 70,552,897 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112903   ⟹   ENSRNOP00000095825
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl763,049,424 - 63,089,064 (-)Ensembl
RefSeq Acc Id: NM_212523   ⟹   NP_997688
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2763,051,894 - 63,089,024 (-)NCBI
Rnor_6.0770,515,832 - 70,552,897 (-)NCBI
Rnor_5.0770,693,375 - 70,727,047 (-)NCBI
RGSC_v3.4767,183,575 - 67,220,766 (-)RGD
Celera760,193,348 - 60,229,555 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_997688 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAS45402 (Get FASTA)   NCBI Sequence Viewer  
  EDM16486 (Get FASTA)   NCBI Sequence Viewer  
  Q6QLM7 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_997688   ⟸   NM_212523
- UniProtKB: Q6QLM7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071539   ⟸   ENSRNOT00000080594
RefSeq Acc Id: ENSRNOP00000007721   ⟸   ENSRNOT00000007721
RefSeq Acc Id: ENSRNOP00000095825   ⟸   ENSRNOT00000112903
Protein Domains
Kinesin motor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6QLM7-F1-model_v2 AlphaFold Q6QLM7 1-1027 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695254
Promoter ID:EPDNEW_R5779
Type:initiation region
Name:Kif5a_1
Description:kinesin family member 5A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0770,552,915 - 70,552,975EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303035 AgrOrtholog
BioCyc Gene G2FUF-33757 BioCyc
Ensembl Genes ENSRNOG00000005299 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000007721.4 UniProtKB/TrEMBL
  ENSRNOP00000071539 ENTREZGENE
  ENSRNOP00000071539.1 UniProtKB/TrEMBL
  ENSRNOP00000095825.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007721.6 UniProtKB/TrEMBL
  ENSRNOT00000080594 ENTREZGENE
  ENSRNOT00000080594.2 UniProtKB/TrEMBL
  ENSRNOT00000112903.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.850.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.250.1590 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kinesin-like_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinesin_motor_CS UniProtKB/TrEMBL
  Kinesin_motor_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinesin_motor_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:314906 UniProtKB/Swiss-Prot
NCBI Gene 314906 ENTREZGENE
PANTHER CENTROMERE PROTEIN E UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KINESIN MOTOR DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Kinesin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kif5a PhenoGen
PRINTS KINESINHEAVY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE KINESIN_MOTOR_1 UniProtKB/TrEMBL
  KINESIN_MOTOR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART KISc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K0Q2_RAT UniProtKB/TrEMBL
  A0A8I6APJ1_RAT UniProtKB/TrEMBL
  F1M8F2_RAT UniProtKB/TrEMBL
  KIF5A_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Kif5a  kinesin family member 5A      Symbol and Name status set to approved 1299863 APPROVED
2005-02-14 Kif5a  kinesin family member 5A      Symbol and Name status set to provisional 70820 PROVISIONAL