Ept7 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Ept7 (Estrogen-induced pituitary tumorigenesis QTL 7) Rattus norvegicus

Symbol: Ept7
Name: Estrogen-induced pituitary tumorigenesis QTL 7
RGD ID: 1576303
Trait: pituitary gland mass   (VT:0010496)    
Measurement Type: pituitary gland wet weight   (CMO:0000853)    
LOD Score: 3.7
P Value: Not Available
Variance: Not Available
Inheritance Type: recessive
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8763,889,858 - 108,889,858RGD_MAPPER_PIPELINE
mRatBN7.2762,004,452 - 101,773,158RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0769,399,586 - 111,043,530RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0769,590,305 - 110,975,995RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4766,201,980 - 107,428,439RGDRGSC3.4
RGSC_v3.1766,222,710 - 107,462,669RGD
Cross Type: Not Available
Strains Crossed: BN/SsNHsd ACI/SegHsd 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Myc is a candidate Gene for Ept7
Trhr is a candidate Gene for Ept7
Cdk4 is a candidate Gene for Ept7


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ept7RatPituitary Neoplasms  IDA 1642526 RGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ept7Ratpituitary gland hyperplasia  IDA 1642526 RGD 

Clinical Measurement
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ept7Ratpituitary gland wet weight  IDA 1642526 RGD 

Experimental Condition
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ept7Rat17 beta-estradiol  IDA 164252627.5mg/ml crystalline implantRGD 
Ept7Ratsurgical implantation  IDA 1642526 RGD 

Measurement Method
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ept7Ratpost excision weight measurement  IDA 1642526 RGD 

Rat Strain
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ept7RatACI/SegHsd  IEA 1642526 RGD 
Ept7RatBN/SsNHsd  IEA 1642526 RGD 

Vertebrate Trait
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ept7Ratpituitary gland mass  IDA 1642526 RGD 


#
Reference Title
Reference Citation
1. Ept7 influences estrogen action in the pituitary gland and body weight of rats. Kurz SG, etal., Mamm Genome. 2014 Jun;25(5-6):244-52. doi: 10.1007/s00335-014-9504-4. Epub 2014 Jan 22.
2. Unpublished observations for Ept QTL Personal communication with Dr. Shull's group
3. Genetic bases of estrogen-induced tumorigenesis in the rat: mapping of loci controlling susceptibility to mammary cancer in a Brown Norway x ACI intercross. Schaffer BS, etal., Cancer Res. 2006 Aug 1;66(15):7793-800.
4. Genetic control of estrogen action in the rat: mapping of QTLs that impact pituitary lactotroph hyperplasia in a BN x ACI intercross. Shull JD, etal., Mamm Genome. 2007 Sep 18;.

Related QTL Description Reference
Emca4 maps to same region RGD:1642522



1 to 20 of 401 rows
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD ID
Symbol
Name
Chr
Start
Stop
Species
1559995Dppa5l1developmental pluripotency associated 5 like 176252504462526042Rat
41034435Trnat-agu22transfer RNA threonine (anticodon AGU) 2276256550262565574Rat
41075389LOC120093627uncharacterized LOC12009362776262278762636248Rat
11399049LOC108351471uncharacterized LOC10835147176268101762702138Rat
40988719LOC120093981small nucleolar RNA SNORA1776268242462682554Rat
1597486Park7-ps1Parkinsonism associated deglycase, pseudogene 176270611562706995Rat
7525893LOC102557532uncharacterized LOC10255753276270896262710729Rat
1588587Atp23ATP23 metallopeptidase and ATP synthase assembly factor homolog76271475262729893Rat
41359680LOC120093628uncharacterized LOC12009362876275332662760239Rat
11399716LOC108351472uncharacterized LOC10835147276280038462804985Rat
2319209Ctdsp2CTD small phosphatase 276280539862825306Rat
620301Aviladvillin76282545962844103Rat
1593058TsfmTs translation elongation factor, mitochondrial76282899762864784Rat
1590711Eef1akmt3EEF1A lysine methyltransferase 376285330462864558Rat
1593036Mettl1methyltransferase 1, tRNA methylguanosine76286486062869202Rat
69192Cyp27b1cytochrome P450, family 27, subfamily b, polypeptide 176286934062876242Rat
1590688Marchf9membrane associated ring-CH-type finger 976287901762882495Rat
621120Cdk4cyclin-dependent kinase 476288612462889562Rat
1309876Tspan31tetraspanin 3176288955262892428Rat
628844Agap2ArfGAP with GTPase domain, ankyrin repeat and PH domain 276289728262914295Rat

1 to 20 of 401 rows
1 to 20 of 516 rows
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Expected Size
Chr
Start
Stop
Species
Match
10935D7Wox1413179359564793595780Ratregion
10936D7Arb520479359562793595833Ratregion
10937D7Wox1515979359562093595781Ratregion
10938D7Wox2911979359563393595754Ratregion
10939D7Mit2721079359563193595843Ratregion
33969D7Mit423979481108594811326Ratregion
34172D7Mgh1221776775960667759823Ratregion
34499D7Mgh713076973622669736356Ratregion
34555D7Mgh614879141244491412594Ratregion
34713D7Mgh1623679125631191256547Ratregion
33648D7Mit513778022129980221436Ratregion
33749D7Mit325679973595699736220Ratregion
36015D7Rat2115579128113091281285Ratregion
35264D7Rat1814879801139698011544Ratregion
36932D7Rat1714879479587794796025Ratregion
37144D7Rat7414077382920473829340Ratregion
37642D7Rat11224678519688685197132Ratregion
37710D7Rat19018879032403890324226Ratregion
37808D7Rat8612078315339283153512Ratregion
37814D7Rat1001977100865992100866189Ratregion
1 to 20 of 516 rows

Flank 1: (D7Rat44)
Rat AssemblyChrPosition (strand)Source
GRCr8763,889,858 - 63,890,004 (+)Marker Load Pipeline
mRatBN7.2762,004,452 - 62,004,598 (+)MAPPER
Rnor_6.0769,399,586 - 69,399,731NCBI
Rnor_5.0769,590,305 - 69,590,450UniSTS
RGSC_v3.4766,201,980 - 66,202,126RGD
RGSC_v3.4766,201,981 - 66,202,126UniSTS
RGSC_v3.1766,222,710 - 66,222,856RGD
Celera759,158,360 - 59,158,505UniSTS
FHH x ACI Map733.38RGD
FHH x ACI Map733.38UniSTS
Cytogenetic Map7 RGD
Peak: (D7Rat19)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21016,729,776 - 16,731,416 (+)MAPPER
mRatBN7.2793,242,123 - 93,242,280 (+)MAPPER
Rnor_6.07101,918,330 - 101,918,486NCBI
Rnor_6.01017,019,618 - 17,021,257NCBI
Rnor_5.01016,916,685 - 16,918,324UniSTS
Rnor_5.07102,486,192 - 102,486,348UniSTS
RGSC_v3.4798,568,414 - 98,568,570UniSTS
RGSC_v3.4798,568,413 - 98,568,570RGD
RGSC_v3.41016,992,235 - 16,993,874UniSTS
RGSC_v3.1798,602,643 - 98,602,800RGD
Celera1016,382,362 - 16,384,001UniSTS
SHRSP x BN Map754.56RGD
SHRSP x BN Map754.56UniSTS
Flank 2: (D7Rat15)
Rat AssemblyChrPosition (strand)Source
mRatBN7.27101,772,987 - 101,773,158 (+)MAPPER
Rnor_6.07111,043,360 - 111,043,530NCBI
Rnor_5.07110,975,825 - 110,975,995UniSTS
RGSC_v3.47107,428,268 - 107,428,439RGD
RGSC_v3.47107,428,269 - 107,428,439UniSTS
RGSC_v3.17107,462,499 - 107,462,669RGD
Celera798,242,639 - 98,242,803UniSTS
RH 3.4 Map7694.6UniSTS
RH 3.4 Map7694.6RGD
RH 2.0 Map7536.9RGD
SHRSP x BN Map757.9199RGD
FHH x ACI Map748.9699RGD


1 to 10 of 72 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat

1 to 10 of 72 rows


Note Type Note Reference
qtl_general inducing agent: 17beta-estradiol (E2) for 196 days 1642526
qtl_general software package used: MAPMANAGER QTX 1642526
qtl_general number of animals used: 230 F2 female rats 1642526
qtl_general region effects the responsivess of the pituitary gland to estrogens; also responsible for gender specific body weight 8662361